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37. Recent Progress in Photodynamic Immunotherapy with Metal‐Based Photosensitizers.

Author

Xiong, Kai, Wei, Fangmian, Chen, Yu, Ji, Liangnian, and Chao, Hui

Abstract

Cancer ranks as a leading cause of death. There is an urgent need to develop minimally invasive methods to eradicate tumors and prevent their recurrence. As a light‐driven modality, photodynamic therapy takes advantage of high tumor selectivity and low normal tissue damage. However, it shows poor potential for preventing tumor recurrence. Immunotherapy is currently being used as an alternative treatment for the control of malignant diseases. Although immunotherapy can establish long‐time immune memory and efficiently protects treated patients from cancer relapse, its clinical efficacy is limited by the minority of patients' responding rate. Recently, photodynamic immunotherapy, which utilizes photosensitizers as an immunotherapy trigger to exert synergistic effects of photodynamic therapy and tumor immunotherapy, has attracted considerable interest. Like all the newly proposed treatments, there is still room for improvement. In this mini review, the progress in photodynamic immunotherapy with metal‐based photosensitizers is summarized. It is hoped that this review can give a broad update on photodynamic immunotherapy and inspire readers. [ABSTRACT FROM AUTHOR]

Published
2023
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40. Photodecaging of a Mitochondria-Localized Iridium(III) Endoperoxide Complex for Two-Photon Photoactivated Therapy under Hypoxia

Author

Kuang, Shi, Wei, Fangmian, Karges, Johannes, Ke, Libing, Xiong, Kai, Liao, Xinxing, Gas- Ser, Gilles, Ji, Liangnian, Chao, Hui, Gasser, Gilles, Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL), ERC, and European Project: 681679, H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC),681679,PhotoMedMet(2017)

Subjects
Photosensitizing Agents, Singlet Oxygen, Medicinal Inorganic Chemistry, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, General Chemistry, Iridium, Biochemistry, Catalysis, Mitochondria, Photoactivated Chemotherapy, Mice, Colloid and Surface Chemistry, Photochemotherapy, Cell Line, Tumor, Neoplasms, Photodynamic Therapy, Animals, Prodrugs, Hypoxia, Bioinorganic Chemistry
Abstract

International audience; Despite the clinical success of photodynamic therapy (PDT), the application of this medical technique is intrinsically limited by the low oxygen concentrations found in cancer tumors which are hampering the production of the therapeutically necessary singlet oxygen (1 O2). To overcome this limitation, we report on a novel mitochondria-localized iridium(III) endoperoxide prodrug (2-O-IrAn), which, upon two-photon irradiation in the NIR, synergistically releases a highly cytotoxic iridium(III) complex (2-IrAn), singlet oxygen and an alkoxy radical. 2-O-IrAn was found to be highly (photo-)toxic in hypoxic tumor cells and multicellular tumor spheroids in the nanomolar range. To provide cancer selectivity and improve the pharmacological properties of 2-O-IrAn, it was encapsulated with a biotin functionalized polymer. The generated nanoparticles were found to nearly fully eradicate the tumor inside a mouse model within a single treatment. This study presents, to the best of our knowledge, the first example of an iridium(III)-based endoperoxide prodrug for synergistic photodynamic therapy/photoactivated chemotherapy, opening up new avenues for the treatment of hypoxic tumors.

Published
2022

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