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18 results on '"Ji, Haoyan"'

16. Dehydrodiisoeugenol Inhibits Colorectal Cancer Growth by Endoplasmic Reticulum Stress Induced Autophagic Pathways

Author

Zhang Kui, Liu Ruochen, Wang Yi, Wang Xiaowen, Yang Liqun, Deng Longfei, Li Chongyang, Ji Haoyan, Hongjuan Cui, Changhong Li, and Pan Guangzhao

Subjects
Dehydrodiisoeugenol, Colorectal cancer, Chemistry, Endoplasmic reticulum, Stress induced, Autophagy, medicine, Cancer research, anatomy_morphology, medicine.disease
Abstract

Dehydrodiisoeugenol (DEH), a novel lignan component extracted from the Nutmeg seeds, displays noticeable anti-inflammatory and anti-allergic effects in digestive system diseases. However, the mechanism of its anti-cancer activity in gastrointestinal cancer is still to be investigated. Here, the anti-cancer effect of DEH to human colorectal cancer and its underlying mechanism were evaluated. The DEH treatment arrests the cell cycle of colorectal cancer cells at G1/S phase, which leading to a significant cell growth inhibition. Moreover, it can induce strong cellular autophagy and the autophagy would be inhibited through autophagic inhibitors with reducing EDH-induced inhibition of cell growth in colorectal cancer cells. Further studies indicated that DEH can also induce endoplasmic reticulum (ER) stress, and could subsequently stimulating autophagy through activating PERK/eIF2α and IRE1α/XBP-1s/CHOP pathways. Knockdown of PERK or IRE1α can significantly decrease the DEH-induced autophagy and retrieve cell viability in cells treated with DEH. What’s more, DEH exhibits significant anti-cancer activities through CDX- and PDX-model as well. Taken together, our studies strongly suggest that DEH might be a potential anti-cancer agent against colorectal cancer via activating ER stress-induced autophagy inhibition.

Published
2020

17. Lycorine hydrochloride inhibits cell proliferation and induces apoptosis through promoting FBXW7-MCL1 axis in gastric cancer

Author

Li, Chongyang, primary, Deng, Chaowei, additional, Pan, Guangzhao, additional, Wang, Xue, additional, Zhang, Kui, additional, Dong, Zhen, additional, Zhao, Gaichao, additional, Tan, Mengqin, additional, Hu, Xiaosong, additional, Shi, Shaomin, additional, Du, Juan, additional, Ji, Haoyan, additional, Wang, Xiaowen, additional, Yang, Liqun, additional, and Cui, Hongjuan, additional

Published
2020
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18. Molecular Characterization of Two Genes Encoding Novel Ca 2+ -Independent Phospholipase A2s from the Silkworm, Bombyx mori .

Author

Hu X, Zhang B, Zheng X, Ji H, Feng K, Hu X, Gul I, Abbas MN, Cui H, and Zhu Y

Abstract

Eicosanoids are crucial downstream signals in the insect immune responses. Phospholipase A2 (PLA2) catalyzes phospholipids, the initial step in eicosanoid biosynthesis. In mammals, the biological roles of Ca 2+ -independent Phospholipase A2 (iPLA2) have been extensively studied; however, only a few studies have attempted to explore iPLA2 functions in insects. In this study, we identified two iPLA2 genes (designated as BmiPLA2A and BmiPLA2B ) in the silkworm, Bombyx mori . BmiPLA2A had a 2427 base pair (bp) open reading frame (ORF) that coded for a protein with 808 amino acids. In contrast, BmiPLA2B had a 1731 bp ORF that coded for a protein with 576 amino acids. Domain analysis revealed that BmiPLA2A had six ankyrin repeat domains, but BmiPLA2B lacks these domains. BmiPLA2A and BmiPLA2B were transcribed widely in various tissues and developmental stages with different expression patterns. The administration of 20-hydroxyecdysone increased their expression levels in the epidermis and hemocytes. Furthermore, challenged with virus, fungus, Gram-negative bacteria, and Gram-positive bacteria induced the expression of BmiPLA2A and BmiPLA2B with variable degrees along with different time points. Our findings imply that BmiPLA2A and BmiPLA2B may have important biological roles in the development and innate immunity of B. mori .

Published
2022
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