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1. Age at lung cancer diagnosis in females versus males who never smoke by race and ethnicity

Author

Blechter, Batel, Wong, Jason Y. Y., Chien, Li-Hsin, Shiraishi, Kouya, Shu, Xiao-Ou, Cai, Qiuyin, Zheng, Wei, Ji, Bu-Tian, Hu, Wei, Rahman, Mohammad L., Jiang, Hsin-Fang, Tsai, Fang-Yu, Huang, Wen-Yi, Gao, Yu-Tang, Han, Xijing, Steinwandel, Mark D., Yang, Gong, Daida, Yihe G., Liang, Su-Ying, Gomez, Scarlett L., DeRouen, Mindy C., Diver, W. Ryan, Reddy, Ananya G., Patel, Alpa V., Le Marchand, Loïc, Haiman, Christopher, Kohno, Takashi, Cheng, Iona, Chang, I-Shou, Hsiung, Chao Agnes, Rothman, Nathaniel, and Lan, Qing

Published
2024
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2. Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

Author

Shi, Jianxin, Shiraishi, Kouya, Choi, Jiyeon, Matsuo, Keitaro, Chen, Tzu-Yu, Dai, Juncheng, Hung, Rayjean J., Chen, Kexin, Shu, Xiao-Ou, Kim, Young Tae, Landi, Maria Teresa, Lin, Dongxin, Zheng, Wei, Yin, Zhihua, Zhou, Baosen, Song, Bao, Wang, Jiucun, Seow, Wei Jie, Song, Lei, Chang, I-Shou, Hu, Wei, Chien, Li-Hsin, Cai, Qiuyin, Hong, Yun-Chul, Kim, Hee Nam, Wu, Yi-Long, Wong, Maria Pik, Richardson, Brian Douglas, Funderburk, Karen M., Li, Shilan, Zhang, Tongwu, Breeze, Charles, Wang, Zhaoming, Blechter, Batel, Bassig, Bryan A., Kim, Jin Hee, Albanes, Demetrius, Wong, Jason Y. Y., Shin, Min-Ho, Chung, Lap Ping, Yang, Yang, An, She-Juan, Zheng, Hong, Yatabe, Yasushi, Zhang, Xu-Chao, Kim, Young-Chul, Caporaso, Neil E., Chang, Jiang, Ho, James Chung Man, Kubo, Michiaki, Daigo, Yataro, Song, Minsun, Momozawa, Yukihide, Kamatani, Yoichiro, Kobayashi, Masashi, Okubo, Kenichi, Honda, Takayuki, Hosgood, Dean H., Kunitoh, Hideo, Patel, Harsh, Watanabe, Shun-ichi, Miyagi, Yohei, Nakayama, Haruhiko, Matsumoto, Shingo, Horinouchi, Hidehito, Tsuboi, Masahiro, Hamamoto, Ryuji, Goto, Koichi, Ohe, Yuichiro, Takahashi, Atsushi, Goto, Akiteru, Minamiya, Yoshihiro, Hara, Megumi, Nishida, Yuichiro, Takeuchi, Kenji, Wakai, Kenji, Matsuda, Koichi, Murakami, Yoshinori, Shimizu, Kimihiro, Suzuki, Hiroyuki, Saito, Motonobu, Ohtaki, Yoichi, Tanaka, Kazumi, Wu, Tangchun, Wei, Fusheng, Dai, Hongji, Machiela, Mitchell J., Su, Jian, Kim, Yeul Hong, Oh, In-Jae, Lee, Victor Ho Fun, Chang, Gee-Chen, Tsai, Ying-Huang, Chen, Kuan-Yu, Huang, Ming-Shyan, Su, Wu-Chou, Chen, Yuh-Min, Seow, Adeline, Park, Jae Yong, Kweon, Sun-Seog, Chen, Kun-Chieh, Gao, Yu-Tang, Qian, Biyun, Wu, Chen, Lu, Daru, Liu, Jianjun, Schwartz, Ann G., Houlston, Richard, Spitz, Margaret R., Gorlov, Ivan P., Wu, Xifeng, Yang, Ping, Lam, Stephen, Tardon, Adonina, Chen, Chu, Bojesen, Stig E., Johansson, Mattias, Risch, Angela, Bickeböller, Heike, Ji, Bu-Tian, Wichmann, H-Erich, Christiani, David C., Rennert, Gadi, Arnold, Susanne, Brennan, Paul, McKay, James, Field, John K., Shete, Sanjay S., Le Marchand, Loic, Liu, Geoffrey, Andrew, Angeline, Kiemeney, Lambertus A., Zienolddiny-Narui, Shan, Grankvist, Kjell, Johansson, Mikael, Cox, Angela, Taylor, Fiona, Yuan, Jian-Min, Lazarus, Philip, Schabath, Matthew B., Aldrich, Melinda C., Jeon, Hyo-Sung, Jiang, Shih Sheng, Sung, Jae Sook, Chen, Chung-Hsing, Hsiao, Chin-Fu, Jung, Yoo Jin, Guo, Huan, Hu, Zhibin, Burdett, Laurie, Yeager, Meredith, Hutchinson, Amy, Hicks, Belynda, Liu, Jia, Zhu, Bin, Berndt, Sonja I., Wu, Wei, Wang, Junwen, Li, Yuqing, Choi, Jin Eun, Park, Kyong Hwa, Sung, Sook Whan, Liu, Li, Kang, Chang Hyun, Wang, Wen-Chang, Xu, Jun, Guan, Peng, Tan, Wen, Yu, Chong-Jen, Yang, Gong, Sihoe, Alan Dart Loon, Chen, Ying, Choi, Yi Young, Kim, Jun Suk, Yoon, Ho-Il, Park, In Kyu, Xu, Ping, He, Qincheng, Wang, Chih-Liang, Hung, Hsiao-Han, Vermeulen, Roel C. H., Cheng, Iona, Wu, Junjie, Lim, Wei-Yen, Tsai, Fang-Yu, Chan, John K. C., Li, Jihua, Chen, Hongyan, Lin, Hsien-Chih, Jin, Li, Liu, Jie, Sawada, Norie, Yamaji, Taiki, Wyatt, Kathleen, Li, Shengchao A., Ma, Hongxia, Zhu, Meng, Wang, Zhehai, Cheng, Sensen, Li, Xuelian, Ren, Yangwu, Chao, Ann, Iwasaki, Motoki, Zhu, Junjie, Jiang, Gening, Fei, Ke, Wu, Guoping, Chen, Chih-Yi, Chen, Chien-Jen, Yang, Pan-Chyr, Yu, Jinming, Stevens, Victoria L., Fraumeni, Jr, Joseph F., Chatterjee, Nilanjan, Gorlova, Olga Y., Hsiung, Chao Agnes, Amos, Christopher I., Shen, Hongbing, Chanock, Stephen J., Rothman, Nathaniel, Kohno, Takashi, and Lan, Qing

Published
2023
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3. Household air pollution and epigenetic aging in Xuanwei, China

Author

Blechter, Batel, Cardenas, Andres, Shi, Junming, Wong, Jason Y.Y., Hu, Wei, Rahman, Mohammad L., Breeze, Charles, Downward, George S., Portengen, Lützen, Zhang, Yongliang, Ning, Bofu, Ji, Bu-Tian, Cawthon, Richard, Li, Jihua, Yang, Kaiyun, Bozack, Anne, Dean Hosgood, H., Silverman, Debra T., Huang, Yunchao, Rothman, Nathaniel, Vermeulen, Roel, and Lan, Qing

Published
2023
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4. Methylated polycyclic aromatic hydrocarbons from household coal use across the life course and risk of lung cancer in a large cohort of 42,420 subjects in Xuanwei, China

Author

Portengen, Lützen, Downward, George, Bassig, Bryan A., Blechter, Batel, Hu, Wei, Wong, Jason Y.Y., Ning, Bofu, Rahman, Mohammad L., Ji, Bu-Tian, Li, Jihua, Yang, Kaiyun, Hosgood, H. Dean, Silverman, Debra T., Rothman, Nathaniel, Huang, Yunchao, Vermeulen, Roel, and Lan, Qing

Published
2023
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5. Exposure to diesel engine exhaust and alterations to the Cys34/Lys525 adductome of human serum albumin

Author

Wong, Jason Y.Y., Imani, Partow, Grigoryan, Hasmik, Bassig, Bryan A., Dai, Yufei, Hu, Wei, Blechter, Batel, Rahman, Mohammad L., Ji, Bu-Tian, Duan, Huawei, Niu, Yong, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Downward, George, Meliefste, Kees, Leng, Shuguang, Fu, Wei, Yang, Jufang, Ren, Dianzhi, Xu, Jun, Zhou, Baosen, Hosgood, H. Dean, Vermeulen, Roel, Zheng, Yuxin, Silverman, Debra T., Rothman, Nathaniel, Rappaport, Stephen M., and Lan, Qing

Published
2022
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6. Occupational exposure to benzene and risk of non‐Hodgkin lymphoma in an extended follow‐up of two population‐based prospective cohorts of Chinese men and women.

Author

Bassig, Bryan A., Shu, Xiao‐Ou, Friesen, Melissa C., Vermeulen, Roel, Purdue, Mark P., Ji, Bu‐Tian, Yang, Gong, Wong, Jason Y. Y., Appel, Nathan, Hu, Wei, Gao, Yu‐Tang, Zheng, Wei, Rothman, Nathaniel, and Lan, Qing

Subjects
PROPORTIONAL hazards models, CHRONIC lymphocytic leukemia, OCCUPATIONAL exposure, CHINESE people, HOCKEY
Abstract

The carcinogenicity of benzene was reevaluated by the International Agency for Research on Cancer in 2017, with the Working Group reaffirming positive yet inconclusive associations with non‐Hodgkin lymphoma (NHL). To extend our previous observation of a significant exposure‐response for cumulative occupational benzene exposure and NHL risk among Chinese women in a population‐based cohort in Shanghai, we extended follow‐up of this cohort and pooled the data with a similarly designed population‐based cohort of men in Shanghai. Cumulative exposure estimates were derived for 134,449 participants in the pooled analysis by combining ordinal job‐exposure matrix intensity ratings with quantitative benzene measurements from an inspection database of Shanghai factories. Associations between benzene exposure metrics and NHL (n = 363 cases including multiple myeloma [MM]) were assessed using Cox proportional hazard models. Ever occupational exposure to benzene in the pooled population was associated with NHL risk (HR = 1.5, 95% CI = 1.2–2.0), and exposure‐response relationships were observed for increasing duration (ptrend =.003) and cumulative exposure (ptrend =.003). Associations with ever exposure, duration, and cumulative exposure were similar for NHL with and without MM in the case definition, including lifetime cumulative exposures in the highest quartile (HR = 1.6, 95% CI = 1.1–2.4 with MM included; HR = 1.7, 95% CI = 1.1–2.7 with MM excluded). An elevated risk of the chronic lymphocytic leukemia subtype was suggested in the pooled analyses (HR for ever vs. never exposure = 2.3, 95% CI = 0.9–5.6). These observations provide additional support for a plausible association between occupational benzene exposure and risk of NHL. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility

Author

Earp, Madalene, Tyrer, Jonathan P, Winham, Stacey J, Lin, Hui-Yi, Chornokur, Ganna, Dennis, Joe, Aben, Katja KH, Anton‐Culver, Hoda, Antonenkova, Natalia, Bandera, Elisa V, Bean, Yukie T, Beckmann, Matthias W, Bjorge, Line, Bogdanova, Natalia, Brinton, Louise A, Brooks-Wilson, Angela, Bruinsma, Fiona, Bunker, Clareann H, Butzow, Ralf, Campbell, Ian G, Carty, Karen, Chang-Claude, Jenny, Cook, Linda S, Cramer, Daniel W, Cunningham, Julie M, Cybulski, Cezary, Dansonka-Mieszkowska, Agnieszka, Despierre, Evelyn, Doherty, Jennifer A, Dörk, Thilo, du Bois, Andreas, Dürst, Matthias, Easton, Douglas F, Eccles, Diana M, Edwards, Robert P, Ekici, Arif B, Fasching, Peter A, Fridley, Brooke L, Gentry-Maharaj, Aleksandra, Giles, Graham G, Glasspool, Rosalind, Goodman, Marc T, Gronwald, Jacek, Harter, Philipp, Hein, Alexander, Heitz, Florian, Hildebrandt, Michelle AT, Hillemanns, Peter, Hogdall, Claus K, Høgdall, Estrid, Hosono, Satoyo, Iversen, Edwin S, Jakubowska, Anna, Jensen, Allan, Ji, Bu-Tian, Jung, Audrey Y, Karlan, Beth Y, Kellar, Melissa, Kiemeney, Lambertus A, Lim, Boon Kiong, Kjaer, Susanne K, Krakstad, Camilla, Kupryjanczyk, Jolanta, Lambrechts, Diether, Lambrechts, Sandrina, Le, Nhu D, Lele, Shashi, Lester, Jenny, Levine, Douglas A, Li, Zheng, Liang, Dong, Lissowska, Jolanta, Lu, Karen, Lubinski, Jan, Lundvall, Lene, Massuger, Leon FAG, Matsuo, Keitaro, McGuire, Valerie, McLaughlin, John R, McNeish, Iain, Menon, Usha, Milne, Roger L, Modugno, Francesmary, Moysich, Kirsten B, Ness, Roberta B, Nevanlinna, Heli, Odunsi, Kunle, Olson, Sara H, Orlow, Irene, Orsulic, Sandra, Paul, James, Pejovic, Tanja, Pelttari, Liisa M, Permuth, Jenny B, Pike, Malcolm C, Poole, Elizabeth M, Rosen, Barry, Rossing, Mary Anne, Rothstein, Joseph H, and Runnebaum, Ingo B

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Genetics, Oncology and Carcinogenesis, Cancer, Women's Health, Ovarian Cancer, Rare Diseases, 2.1 Biological and endogenous factors, A Kinase Anchor Proteins, Carcinoma, Ovarian Epithelial, Female, Genetic Association Studies, Genetic Predisposition to Disease, Genotype, Humans, Monomeric GTP-Binding Proteins, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Rho Guanine Nucleotide Exchange Factors, Risk Factors, General Science & Technology
Abstract

Epithelial ovarian cancer (EOC) is the fifth leading cause of cancer mortality in American women. Normal ovarian physiology is intricately connected to small GTP binding proteins of the Ras superfamily (Ras, Rho, Rab, Arf, and Ran) which govern processes such as signal transduction, cell proliferation, cell motility, and vesicle transport. We hypothesized that common germline variation in genes encoding small GTPases is associated with EOC risk. We investigated 322 variants in 88 small GTPase genes in germline DNA of 18,736 EOC patients and 26,138 controls of European ancestry using a custom genotype array and logistic regression fitting log-additive models. Functional annotation was used to identify biofeatures and expression quantitative trait loci that intersect with risk variants. One variant, ARHGEF10L (Rho guanine nucleotide exchange factor 10 like) rs2256787, was associated with increased endometrioid EOC risk (OR = 1.33, p = 4.46 x 10-6). Other variants of interest included another in ARHGEF10L, rs10788679, which was associated with invasive serous EOC risk (OR = 1.07, p = 0.00026) and two variants in AKAP6 (A-kinase anchoring protein 6) which were associated with risk of invasive EOC (rs1955513, OR = 0.90, p = 0.00033; rs927062, OR = 0.94, p = 0.00059). Functional annotation revealed that the two ARHGEF10L variants were located in super-enhancer regions and that AKAP6 rs927062 was associated with expression of GTPase gene ARHGAP5 (Rho GTPase activating protein 5). Inherited variants in ARHGEF10L and AKAP6, with potential transcriptional regulatory function and association with EOC risk, warrant investigation in independent EOC study populations.

Published
2018

9. Sub-multiplicative interaction between polygenic risk score and household coal use in relation to lung adenocarcinoma among never-smoking women in Asia

Author

Blechter, Batel, Wong, Jason Y.Y., Agnes Hsiung, Chao, Hosgood, H.Dean, Yin, Zhihua, Shu, Xiao-Ou, Zhang, Han, Shi, Jianxin, Song, Lei, Song, Minsun, Zheng, Wei, Wang, Zhaoming, Caporaso, Neil, Burdette, Laurie, Yeager, Meredith, Berndt, Sonja I., Teresa Landi, Maria, Chen, Chien-Jen, Chang, Gee-Chen, Hsiao, Chin-Fu, Tsai, Ying-Huang, Chen, Kuan-Yu, Huang, Ming-Shyan, Su, Wu-Chou, Chen, Yuh-Min, Chien, Li-Hsin, Chen, Chung-Hsing, Yang, Tsung-Ying, Wang, Chih-Liang, Hung, Jen-Yu, Lin, Chien-Chung, Perng, Reury-Perng, Chen, Chih-Yi, Chen, Kun-Chieh, Li, Yao-Jen, Yu, Chong-Jen, Chen, Yi-Song, Chen, Ying-Hsiang, Tsai, Fang-Yu, Jie Seow, Wei, Bassig, Bryan A., Hu, Wei, Ji, Bu-Tian, Wu, Wei, Guan, Peng, He, Qincheng, Gao, Yu-Tang, Cai, Qiuyin, Chow, Wong-Ho, Xiang, Yong-Bing, Lin, Dongxin, Wu, Chen, Wu, Yi-Long, Shin, Min-Ho, Hong, Yun-Chul, Matsuo, Keitaro, Chen, Kexin, Pik Wong, Maria, Lu, Daru, Jin, Li, Wang, Jiu-Cun, Seow, Adeline, Wu, Tangchun, Shen, Hongbing, Fraumeni, Joseph F., Yang, Pan-Chyr, Chang, I-Shou, Zhou, Baosen, Chanock, Stephen J., Rothman, Nathaniel, Chatterjee, Nilanjan, and Lan, Qing

Published
2021
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10. A proteome‐wide analysis unveils a core Epstein–Barr virus antibody signature of classic Hodgkin lymphoma across ethnically diverse populations.

Author

Sarathkumara, Yomani D., Xian, Rena R., Liu, Zhiwei, Yu, Kelly J., Chan, John K. C., Kwong, Yok‐Lam, Lam, Tai Hing, Liang, Raymond, Chiu, Brian, Xu, Jun, Hu, Wei, Ji, Bu‐Tian, Coghill, Anna E., Kelly, Ashton M., Pfeiffer, Ruth M., Rothman, Nathaniel, Ambinder, Richard F., Hildesheim, Allan, Lan, Qing, and Proietti, Carla

Subjects
VIRAL antibodies, HUMORAL immunity, ANTIBODY formation, HODGKIN'S disease, ONCOGENIC viruses
Abstract

Epstein–Barr virus (EBV) is an oncogenic virus associated with various malignancies, including classical Hodgkin lymphoma (cHL). Despite its known association, the specific role of humoral immune response to EBV remains poorly characterized in cHL. To address this, we conducted a study using a custom protein microarray to measure the antibody responses in cHL patients and matched healthy controls recruited from an East‐Asian hospital‐based case–control study. We identified 16 IgG antibodies significantly elevated in EBV‐positive cHL compared with controls, defining an "East‐Asian antibody signature of EBV‐positive cHL." We evaluated responses against these 16 antibodies in a distinct European population, leveraging data from our previous European cHL case–control study from the UK, Denmark, and Sweden. A subset of antibodies (14/16, 87.5%) from the "East‐Asian antibody signature of EBV‐positive cHL" exhibited significant associations with cHL in the European population. Conversely, we assessed the "European antibody signature of EBV‐positive cHL" identified in our prior study which consisted of 18 EBV antibodies (2 IgA, 16 IgG), in the East‐Asian population. A subset of these antibodies (15/18, 83.3%) maintained significant associations with cHL in the East‐Asian population. This cross‐comparison of antibody signatures underscores the robust generalizability of EBV antibodies across populations. Five anti‐EBV IgG antibodies (LMP‐1, TK, BALF2, BDLF3, and BBLF1), found in both population‐specific antibody signatures, represent a "core signature of EBV‐positive cHL." Our findings suggest that the antibody responses targeting these core EBV proteins reflect a specific EBV gene expression pattern, serving as potential biomarkers for EBV‐positive cHL independent of population‐specific factors. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women

Author

Wong, Jason Y.Y., Zhang, Han, Hsiung, Chao A., Shiraishi, Kouya, Yu, Kai, Matsuo, Keitaro, Wong, Maria Pik, Hong, Yun-Chul, Wang, Jiucun, Seow, Wei Jie, Wang, Zhaoming, Song, Minsun, Kim, Hee Nam, Chang, I-Shou, Chatterjee, Nilanjan, Hu, Wei, Wu, Chen, Mitsudomi, Tetsuya, Zheng, Wei, Kim, Jin Hee, Seow, Adeline, Caporaso, Neil E., Shin, Min-Ho, Chung, Lap Ping, An, She-Juan, Wang, Ping, Yang, Yang, Zheng, Hong, Yatabe, Yasushi, Zhang, Xu-Chao, Kim, Young Tae, Cai, Qiuyin, Yin, Zhihua, Kim, Young-Chul, Bassig, Bryan A., Chang, Jiang, Ho, James Chung Man, Ji, Bu-Tian, Daigo, Yataro, Ito, Hidemi, Momozawa, Yukihide, Ashikawa, Kyota, Kamatani, Yoichiro, Honda, Takayuki, Hosgood, H. Dean, Sakamoto, Hiromi, Kunitoh, Hideo, Tsuta, Koji, Watanabe, Shun-ichi, Kubo, Michiaki, Miyagi, Yohei, Nakayama, Haruhiko, Matsumoto, Shingo, Tsuboi, Masahiro, Goto, Koichi, Shi, Jianxin, Song, Lei, Hua, Xing, Takahashi, Atsushi, Goto, Akiteru, Minamiya, Yoshihiro, Shimizu, Kimihiro, Tanaka, Kazumi, Wei, Fusheng, Matsuda, Fumihiko, Su, Jian, Kim, Yeul Hong, Oh, In-Jae, Song, Fengju, Su, Wu-Chou, Chen, Yu-Min, Chang, Gee-Chen, Chen, Kuan-Yu, Huang, Ming-Shyan, Chien, Li-Hsin, Xiang, Yong-Bing, Park, Jae Yong, Kweon, Sun-Seog, Chen, Chien-Jen, Lee, Kyoung-Mu, Blechter, Batel, Li, Haixin, Gao, Yu-Tang, Qian, Biyun, Lu, Daru, Liu, Jianjun, Jeon, Hyo-Sung, Hsiao, Chin-Fu, Sung, Jae Sook, Tsai, Ying-Huang, Jung, Yoo Jin, Guo, Huan, Hu, Zhibin, Wang, Wen-Chang, Chung, Charles C., Burdett, Laurie, Yeager, Meredith, Hutchinson, Amy, Berndt, Sonja I., Wu, Wei, Pang, Herbert, Li, Yuqing, Choi, Jin Eun, Park, Kyong Hwa, Sung, Sook Whan, Liu, Li, Kang, C.H., Zhu, Meng, Chen, Chung-Hsing, Yang, Tsung-Ying, Xu, Jun, Guan, Peng, Tan, Wen, Wang, Chih-Liang, Hsin, Michael, Sit, Ko-Yung, Ho, James, Chen, Ying, Choi, Yi Young, Hung, Jen-Yu, Kim, Jun Suk, Yoon, Ho Il, Lin, Chien-Chung, Park, In Kyu, Xu, Ping, Wang, Yuzhuo, He, Qincheng, Perng, Reury-Perng, Chen, Chih-Yi, Vermeulen, Roel, Wu, Junjie, Lim, Wei-Yen, Chen, Kun-Chieh, Li, Yao-Jen, Li, Jihua, Chen, Hongyan, Yu, Chong-Jen, Jin, Li, Chen, Tzu-Yu, Jiang, Shih-Sheng, Liu, Jie, Yamaji, Taiki, Hicks, Belynda, Wyatt, Kathleen, Li, Shengchao A., Dai, Juncheng, Ma, Hongxia, Jin, Guangfu, Song, Bao, Wang, Zhehai, Cheng, Sensen, Li, Xuelian, Ren, Yangwu, Cui, Ping, Iwasaki, Motoki, Shimazu, Taichi, Tsugane, Shoichiro, Zhu, Junjie, Yang, Kaiyun, Jiang, Gening, Fei, Ke, Wu, Guoping, Lin, Hsien-Chin, Chen, Hui-Ling, Fang, Yao-Huei, Tsai, Fang-Yu, Hsieh, Wan-Shan, Yu, Jinming, Stevens, Victoria L., Laird-Offringa, Ite A., Marconett, Crystal N., Rieswijk, Linda, Chao, Ann, Yang, Pan-Chyr, Shu, Xiao-Ou, Wu, Tangchun, Wu, Y.L., Lin, Dongxin, Chen, Kexin, Zhou, Baosen, Huang, Yun-Chao, Kohno, Takashi, Shen, Hongbing, Chanock, Stephen J., Rothman, Nathaniel, and Lan, Qing

Published
2020
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12. A nested case‐control study of untargeted plasma metabolomics and lung cancer among never‐smoking women within the prospective Shanghai Women's Health Study

Author

Rahman, Mohammad L., primary, Shu, Xiao‐Ou, additional, Jones, Dean P., additional, Hu, Wei, additional, Ji, Bu‐tian, additional, Blechter, Batel, additional, Wong, Jason Y. Y., additional, Cai, Qiuyin, additional, Yang, Gong, additional, Gao, Yu‐Tang, additional, Zheng, Wei, additional, Rothman, Nathaniel, additional, Walker, Douglas, additional, and Lan, Qing, additional

Published
2024
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13. Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer

Author

Hampras, Shalaka S, Sucheston-Campbell, Lara E, Cannioto, Rikki, Chang-Claude, Jenny, Modugno, Francesmary, Dörk, Thilo, Hillemanns, Peter, Preus, Leah, Knutson, Keith L, Wallace, Paul K, Hong, Chi-Chen, Friel, Grace, Davis, Warren, Nesline, Mary, Pearce, Celeste L, Kelemen, Linda E, Goodman, Marc T, Bandera, Elisa V, Terry, Kathryn L, Schoof, Nils, Eng, Kevin H, Clay, Alyssa, Singh, Prashant K, Joseph, Janine M, Aben, Katja KH, Anton-Culver, Hoda, Antonenkova, Natalia, Baker, Helen, Bean, Yukie, Beckmann, Matthias W, Bisogna, Maria, Bjorge, Line, Bogdanova, Natalia, Brinton, Louise A, Brooks-Wilson, Angela, Bruinsma, Fiona, Butzow, Ralf, Campbell, Ian G, Carty, Karen, Cook, Linda S, Cramer, Daniel W, Cybulski, Cezary, Dansonka-Mieszkowska, Agnieszka, Dennis, Joe, Despierre, Evelyn, Dicks, Ed, Doherty, Jennifer A, du Bois, Andreas, Dürst, Matthias, Easton, Doug, Eccles, Diana, Edwards, Robert P, Ekici, Arif B, Fasching, Peter A, Fridley, Brooke L, Gao, Yu-Tang, Gentry-Maharaj, Aleksandra, Giles, Graham G, Glasspool, Rosalind, Gronwald, Jacek, Harrington, Patricia, Harter, Philipp, Hasmad, Hanis Nazihah, Hein, Alexander, Heitz, Florian, Hildebrandt, Michelle AT, Hogdall, Claus, Hogdall, Estrid, Hosono, Satoyo, Iversen, Edwin S, Jakubowska, Anna, Jensen, Allan, Ji, Bu-Tian, Karlan, Beth Y, Kellar, Melissa, Kelley, Joseph L, Kiemeney, Lambertus A, Klapdor, Rüdiger, Kolomeyevskaya, Nonna, Krakstad, Camilla, Kjaer, Susanne K, Kruszka, Bridget, Kupryjanczyk, Jolanta, Lambrechts, Diether, Lambrechts, Sandrina, Le, Nhu D, Lee, Alice W, Lele, Shashikant, Leminen, Arto, Lester, Jenny, Levine, Douglas A, Liang, Dong, Lissowska, Jolanta, Liu, Song, Lu, Karen, Lubinski, Jan, Lundvall, Lene, Massuger, Leon FAG, Matsuo, Keitaro, and McGuire, Valeria

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Rare Diseases, Genetics, Ovarian Cancer, Cancer, Women's Health, 2.1 Biological and endogenous factors, Adenocarcinoma, Clear Cell, Adult, Aged, Carcinoma, Ovarian Epithelial, Female, Gene Expression Regulation, Neoplastic, Gene Frequency, Genetic Predisposition to Disease, Genotype, Humans, Middle Aged, Neoplasms, Glandular and Epithelial, Ovarian Neoplasms, Polymorphism, Single Nucleotide, Protein Serine-Threonine Kinases, Receptor, Transforming Growth Factor-beta Type II, Receptors, Transforming Growth Factor beta, Risk Factors, T-Lymphocytes, Regulatory, ovarian cancer, immunosuppression, biomarkers, genetic variation, TGFBR2, Oncology and carcinogenesis
Abstract

BackgroundRegulatory T (Treg) cells, a subset of CD4+ T lymphocytes, are mediators of immunosuppression in cancer, and, thus, variants in genes encoding Treg cell immune molecules could be associated with ovarian cancer.MethodsIn a population of 15,596 epithelial ovarian cancer (EOC) cases and 23,236 controls, we measured genetic associations of 1,351 SNPs in Treg cell pathway genes with odds of ovarian cancer and tested pathway and gene-level associations, overall and by histotype, for the 25 genes, using the admixture likelihood (AML) method. The most significant single SNP associations were tested for correlation with expression levels in 44 ovarian cancer patients.ResultsThe most significant global associations for all genes in the pathway were seen in endometrioid ( p = 0.082) and clear cell ( p = 0.083), with the most significant gene level association seen with TGFBR2 ( p = 0.001) and clear cell EOC. Gene associations with histotypes at p < 0.05 included: IL12 ( p = 0.005 and p = 0.008, serous and high-grade serous, respectively), IL8RA ( p = 0.035, endometrioid and mucinous), LGALS1 ( p = 0.03, mucinous), STAT5B ( p = 0.022, clear cell), TGFBR1 ( p = 0.021 endometrioid) and TGFBR2 ( p = 0.017 and p = 0.025, endometrioid and mucinous, respectively).ConclusionsCommon inherited gene variation in Treg cell pathways shows some evidence of germline genetic contribution to odds of EOC that varies by histologic subtype and may be associated with mRNA expression of immune-complex receptor in EOC patients.

Published
2016

14. Epithelial-Mesenchymal Transition (EMT) Gene Variants and Epithelial Ovarian Cancer (EOC) Risk.

Author

Amankwah, Ernest K, Lin, Hui-Yi, Tyrer, Jonathan P, Lawrenson, Kate, Dennis, Joe, Chornokur, Ganna, Aben, Katja KH, Anton-Culver, Hoda, Antonenkova, Natalia, Bruinsma, Fiona, Bandera, Elisa V, Bean, Yukie T, Beckmann, Matthias W, Bisogna, Maria, Bjorge, Line, Bogdanova, Natalia, Brinton, Louise A, Brooks-Wilson, Angela, Bunker, Clareann H, Butzow, Ralf, Campbell, Ian G, Carty, Karen, Chen, Zhihua, Chen, Y Ann, Chang-Claude, Jenny, Cook, Linda S, Cramer, Daniel W, Cunningham, Julie M, Cybulski, Cezary, Dansonka-Mieszkowska, Agnieszka, du Bois, Andreas, Despierre, Evelyn, Dicks, Ed, Doherty, Jennifer A, Dörk, Thilo, Dürst, Matthias, Easton, Douglas F, Eccles, Diana M, Edwards, Robert P, Ekici, Arif B, Fasching, Peter A, Fridley, Brooke L, Gao, Yu-Tang, Gentry-Maharaj, Aleksandra, Giles, Graham G, Glasspool, Rosalind, Goodman, Marc T, Gronwald, Jacek, Harrington, Patricia, Harter, Philipp, Hasmad, Hanis N, Hein, Alexander, Heitz, Florian, Hildebrandt, Michelle AT, Hillemanns, Peter, Hogdall, Claus K, Hogdall, Estrid, Hosono, Satoyo, Iversen, Edwin S, Jakubowska, Anna, Jensen, Allan, Ji, Bu-Tian, Karlan, Beth Y, Jim, Heather, Kellar, Melissa, Kiemeney, Lambertus A, Krakstad, Camilla, Kjaer, Susanne K, Kupryjanczyk, Jolanta, Lambrechts, Diether, Lambrechts, Sandrina, Le, Nhu D, Lee, Alice W, Lele, Shashi, Leminen, Arto, Lester, Jenny, Levine, Douglas A, Liang, Dong, Lim, Boon Kiong, Lissowska, Jolanta, Lu, Karen, Lubinski, Jan, Lundvall, Lene, Massuger, Leon FAG, Matsuo, Keitaro, McGuire, Valerie, McLaughlin, John R, McNeish, Ian, Menon, Usha, Milne, Roger L, Modugno, Francesmary, Moysich, Kirsten B, Ness, Roberta B, Nevanlinna, Heli, Eilber, Ursula, Odunsi, Kunle, Olson, Sara H, Orlow, Irene, Orsulic, Sandra, and Weber, Rachel Palmieri

Subjects
Georgia Chenevix-Trench on behalf of the AOCS management group, Humans, Neoplasms, Glandular and Epithelial, Ovarian Neoplasms, Genetic Predisposition to Disease, Odds Ratio, Risk, Genotype, Polymorphism, Single Nucleotide, Adult, Aged, Middle Aged, European Continental Ancestry Group, Female, Genome-Wide Association Study, Epithelial-Mesenchymal Transition, Carcinoma, Ovarian Epithelial, epithelial-mesenchymal transition, ovarian cancer, single-nucleotide polymorphisms, Neoplasms, Glandular and Epithelial, Polymorphism, Single Nucleotide, Carcinoma, Ovarian Epithelial, Epidemiology, Public Health and Health Services, Genetics
Abstract

Epithelial-mesenchymal transition (EMT) is a process whereby epithelial cells assume mesenchymal characteristics to facilitate cancer metastasis. However, EMT also contributes to the initiation and development of primary tumors. Prior studies that explored the hypothesis that EMT gene variants contribute to epithelial ovarian carcinoma (EOC) risk have been based on small sample sizes and none have sought replication in an independent population. We screened 15,816 single-nucleotide polymorphisms (SNPs) in 296 genes in a discovery phase using data from a genome-wide association study of EOC among women of European ancestry (1,947 cases and 2,009 controls) and identified 793 variants in 278 EMT-related genes that were nominally (P < 0.05) associated with invasive EOC. These SNPs were then genotyped in a larger study of 14,525 invasive-cancer patients and 23,447 controls. A P-value

Published
2015

15. Network-Based Integration of GWAS and Gene Expression Identifies a HOX-Centric Network Associated with Serous Ovarian Cancer Risk.

Author

Kar, Siddhartha P, Tyrer, Jonathan P, Li, Qiyuan, Lawrenson, Kate, Aben, Katja KH, Anton-Culver, Hoda, Antonenkova, Natalia, Chenevix-Trench, Georgia, Australian Cancer Study, Australian Ovarian Cancer Study Group, Baker, Helen, Bandera, Elisa V, Bean, Yukie T, Beckmann, Matthias W, Berchuck, Andrew, Bisogna, Maria, Bjørge, Line, Bogdanova, Natalia, Brinton, Louise, Brooks-Wilson, Angela, Butzow, Ralf, Campbell, Ian, Carty, Karen, Chang-Claude, Jenny, Chen, Yian Ann, Chen, Zhihua, Cook, Linda S, Cramer, Daniel, Cunningham, Julie M, Cybulski, Cezary, Dansonka-Mieszkowska, Agnieszka, Dennis, Joe, Dicks, Ed, Doherty, Jennifer A, Dörk, Thilo, du Bois, Andreas, Dürst, Matthias, Eccles, Diana, Easton, Douglas F, Edwards, Robert P, Ekici, Arif B, Fasching, Peter A, Fridley, Brooke L, Gao, Yu-Tang, Gentry-Maharaj, Aleksandra, Giles, Graham G, Glasspool, Rosalind, Goode, Ellen L, Goodman, Marc T, Grownwald, Jacek, Harrington, Patricia, Harter, Philipp, Hein, Alexander, Heitz, Florian, Hildebrandt, Michelle AT, Hillemanns, Peter, Hogdall, Estrid, Hogdall, Claus K, Hosono, Satoyo, Iversen, Edwin S, Jakubowska, Anna, Paul, James, Jensen, Allan, Ji, Bu-Tian, Karlan, Beth Y, Kjaer, Susanne K, Kelemen, Linda E, Kellar, Melissa, Kelley, Joseph, Kiemeney, Lambertus A, Krakstad, Camilla, Kupryjanczyk, Jolanta, Lambrechts, Diether, Lambrechts, Sandrina, Le, Nhu D, Lee, Alice W, Lele, Shashi, Leminen, Arto, Lester, Jenny, Levine, Douglas A, Liang, Dong, Lissowska, Jolanta, Lu, Karen, Lubinski, Jan, Lundvall, Lene, Massuger, Leon, Matsuo, Keitaro, McGuire, Valerie, McLaughlin, John R, McNeish, Iain A, Menon, Usha, Modugno, Francesmary, Moysich, Kirsten B, Narod, Steven A, Nedergaard, Lotte, Ness, Roberta B, Nevanlinna, Heli, Odunsi, Kunle, Olson, Sara H, and Orlow, Irene

Subjects
Australian Cancer Study, Australian Ovarian Cancer Study Group, Humans, Cystadenocarcinoma, Serous, Ovarian Neoplasms, Genetic Predisposition to Disease, Nuclear Proteins, Transcription Factors, DNA, Neoplasm, Morbidity, Risk Factors, Gene Expression Regulation, Neoplastic, Genotype, Female, Genome-Wide Association Study, Global Health, Ovarian Cancer, Biotechnology, Cancer, Genetics, Rare Diseases, Prevention, Human Genome, 2.1 Biological and endogenous factors, Epidemiology, Medical and Health Sciences
Abstract

BackgroundGenome-wide association studies (GWAS) have so far reported 12 loci associated with serous epithelial ovarian cancer (EOC) risk. We hypothesized that some of these loci function through nearby transcription factor (TF) genes and that putative target genes of these TFs as identified by coexpression may also be enriched for additional EOC risk associations.MethodsWe selected TF genes within 1 Mb of the top signal at the 12 genome-wide significant risk loci. Mutual information, a form of correlation, was used to build networks of genes strongly coexpressed with each selected TF gene in the unified microarray dataset of 489 serous EOC tumors from The Cancer Genome Atlas. Genes represented in this dataset were subsequently ranked using a gene-level test based on results for germline SNPs from a serous EOC GWAS meta-analysis (2,196 cases/4,396 controls).ResultsGene set enrichment analysis identified six networks centered on TF genes (HOXB2, HOXB5, HOXB6, HOXB7 at 17q21.32 and HOXD1, HOXD3 at 2q31) that were significantly enriched for genes from the risk-associated end of the ranked list (P < 0.05 and FDR < 0.05). These results were replicated (P < 0.05) using an independent association study (7,035 cases/21,693 controls). Genes underlying enrichment in the six networks were pooled into a combined network.ConclusionWe identified a HOX-centric network associated with serous EOC risk containing several genes with known or emerging roles in serous EOC development.ImpactNetwork analysis integrating large, context-specific datasets has the potential to offer mechanistic insights into cancer susceptibility and prioritize genes for experimental characterization.

Published
2015

16. Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer.

Author

Lawrenson, Kate, Li, Qiyuan, Kar, Siddhartha, Seo, Ji-Heui, Tyrer, Jonathan, Spindler, Tassja J, Lee, Janet, Chen, Yibu, Karst, Alison, Drapkin, Ronny, Aben, Katja KH, Anton-Culver, Hoda, Antonenkova, Natalia, Australian Ovarian Cancer Study Group, Baker, Helen, Bandera, Elisa V, Bean, Yukie, Beckmann, Matthias W, Berchuck, Andrew, Bisogna, Maria, Bjorge, Line, Bogdanova, Natalia, Brinton, Louise A, Brooks-Wilson, Angela, Bruinsma, Fiona, Butzow, Ralf, Campbell, Ian G, Carty, Karen, Chang-Claude, Jenny, Chenevix-Trench, Georgia, Chen, Anne, Chen, Zhihua, Cook, Linda S, Cramer, Daniel W, Cunningham, Julie M, Cybulski, Cezary, Dansonka-Mieszkowska, Agnieszka, Dennis, Joe, Dicks, Ed, Doherty, Jennifer A, Dörk, Thilo, du Bois, Andreas, Dürst, Matthias, Eccles, Diana, Easton, Douglas T, Edwards, Robert P, Eilber, Ursula, Ekici, Arif B, Fasching, Peter A, Fridley, Brooke L, Gao, Yu-Tang, Gentry-Maharaj, Aleksandra, Giles, Graham G, Glasspool, Rosalind, Goode, Ellen L, Goodman, Marc T, Grownwald, Jacek, Harrington, Patricia, Harter, Philipp, Hasmad, Hanis Nazihah, Hein, Alexander, Heitz, Florian, Hildebrandt, Michelle AT, Hillemanns, Peter, Hogdall, Estrid, Hogdall, Claus, Hosono, Satoyo, Iversen, Edwin S, Jakubowska, Anna, James, Paul, Jensen, Allan, Ji, Bu-Tian, Karlan, Beth Y, Kruger Kjaer, Susanne, Kelemen, Linda E, Kellar, Melissa, Kelley, Joseph L, Kiemeney, Lambertus A, Krakstad, Camilla, Kupryjanczyk, Jolanta, Lambrechts, Diether, Lambrechts, Sandrina, Le, Nhu D, Lee, Alice W, Lele, Shashi, Leminen, Arto, Lester, Jenny, Levine, Douglas A, Liang, Dong, Lissowska, Jolanta, Lu, Karen, Lubinski, Jan, Lundvall, Lene, Massuger, Leon FAG, Matsuo, Keitaro, McGuire, Valerie, McLaughlin, John R, Nevanlinna, Heli, McNeish, Ian, and Menon, Usha

Subjects
Australian Ovarian Cancer Study Group, Cell Line, Tumor, Humans, Neoplasms, Glandular and Epithelial, Ovarian Neoplasms, Genetic Predisposition to Disease, Homeodomain Proteins, Neoplasm Proteins, Gene Expression Regulation, Neoplastic, Protein Binding, Quantitative Trait Loci, Female, Nuchal Cord, Genetic Association Studies, Carcinoma, Ovarian Epithelial, Cell Line, Tumor, Neoplasms, Glandular and Epithelial, Gene Expression Regulation, Neoplastic, Carcinoma, Ovarian Epithelial, Rare Diseases, Prevention, Ovarian Cancer, Biotechnology, Human Genome, Cancer, Genetics, 2.1 Biological and endogenous factors
Abstract

Genome-wide association studies have reported 11 regions conferring risk of high-grade serous epithelial ovarian cancer (HGSOC). Expression quantitative trait locus (eQTL) analyses can identify candidate susceptibility genes at risk loci. Here we evaluate cis-eQTL associations at 47 regions associated with HGSOC risk (P≤10(-5)). For three cis-eQTL associations (P

Published
2015

17. Dietary isoflavones, urinary isoflavonoids, and risk of ischemic stroke in women 1–3

Author

Yu, Danxia, Shu, Xiao-Ou, Li, Honglan, Yang, Gong, Cai, Qiuyin, Xiang, Yong-Bing, Ji, Bu-Tian, Franke, Adrian A, Gao, Yu-Tang, Zheng, Wei, and Zhang, Xianglan

Subjects
Aging, Clinical Research, Brain Disorders, Prevention, Nutrition, Stroke, Estrogen, Complementary and Integrative Health, Adult, Aged, Asian People, Case-Control Studies, Chromatography, High Pressure Liquid, Diet, Female, Follow-Up Studies, Humans, Isoflavones, Middle Aged, Multivariate Analysis, Nutrition Assessment, Prospective Studies, Risk Factors, Soybeans, Surveys and Questionnaires, ischemic stroke, phytoestrogen, prospective cohort study, soy isoflavone, women, Engineering, Medical and Health Sciences, Nutrition & Dietetics
Abstract

BackgroundHormone therapy has been shown to increase risk of ischemic stroke in women. Plant-derived estrogens, particularly soy isoflavones, are known to have some estrogenic effects and have been marketed as natural alternatives to hormone therapy. Concerns have been raised about whether high isoflavone exposure may be related to ischemic stroke risk as well.ObjectiveWe examined the dietary intake of isoflavones and the urinary excretion of isoflavonoids in relation to risk of ischemic stroke in women.DesignA prospective cohort study was conducted in 66,832 Chinese women (aged 40-70 y) who had no cardiovascular disease or cancer at baseline. Usual dietary intakes were assessed via in-person interviews with the use of a validated food-frequency questionnaire. Incident strokes were ascertained during follow-up home visits and confirmed by medical records. We also conducted a nested case-control study in postmenopausal women who had never used hormone therapy, including 1422 incident ischemic stroke cases and 1422 controls individually matched by age, date and time of urine sample collection, time since last meal, and use of antibiotics. Urinary isoflavonoids were measured with the use of high-performance liquid chromatography coupled with mass spectrometry.ResultsDuring a mean follow-up of 10 y, 3110 incident ischemic strokes were verified. Dietary isoflavone intake was associated with increased risk of ischemic stroke; multivariable-adjusted HRs from lowest to highest quintiles were 1.00, 1.05, 1.10, 1.11, and 1.24, respectively (95% CI: 1.08, 1.42; P-trend = 0.002). In the case-control study, a similar positive association was observed for dietary isoflavones, but no significant associations were shown for the urinary isoflavonoid concentration [OR: 1.01 (95% CI: 0.77, 1.32) for comparison of extreme quintiles].ConclusionsA habitually high intake of soy isoflavones may be associated with a modest but significant increase in risk of ischemic stroke in women. However, no association was shown for the urinary excretion of isoflavonoids.

Published
2015

18. Genome-wide significant risk associations for mucinous ovarian carcinoma (vol 47, pg 888, 2015)

Author

Kelemen, Linda E, Lawrenson, Kate, Tyrer, Jonathan, Li, Qiyuan, Lee, Janet M, Seo, Ji-Heui, Phelan, Catherine M, Beesley, Jonathan, Chen, Xiaoqing, Spindler, Tassja J, Aben, Katja KH, Anton-Culver, Hoda, Antonenkova, Natalia, Baker, Helen, Bandera, Elisa V, Bean, Yukie, Beckmann, Matthias W, Bisogna, Maria, Bjorge, Line, Bogdanova, Natalia, Brinton, Louise A, Brooks-Wilson, Angela, Bruinsma, Fiona, Butzow, Ralf, Campbell, Ian G, Carty, Karen, Chang-Claude, Jenny, Chen, Y Ann, Chen, Zhihua, Cook, Linda S, Cramer, Daniel W, Cunningham, Julie M, Cybulski, Cezary, Dansonka-Mieszkowska, Agnieszka, Dennis, Joe, Dicks, Ed, Doherty, Jennifer A, Doerk, Thilo, du Bois, Andreas, Duerst, Matthias, Eccles, Diana, Easton, Douglas T, Edwards, Robert P, Eilber, Ursula, Ekici, Arif B, Engelholm, Svend Aage, Fasching, Peter A, Fridley, Brooke L, Gao, Yu-Tang, Gentry-Maharaj, Aleksandra, Giles, Graham G, Glasspool, Rosalind, Goode, Ellen L, Goodman, Marc T, Grownwald, Jacek, Harrington, Patricia, Harter, Philipp, Hasmad, Hanis Nazihah, Hein, Alexander, Heitz, Florian, Hildebrandt, Michelle AT, Hillemanns, Peter, Hogdall, Estrid, Hogdall, Claus, Hosono, Satoyo, Iversen, Edwin S, Jakubowska, Anna, Jensen, Allan, Ji, Bu-Tian, Karlan, Beth Y, Kellar, Melissa, Kelley, Joseph L, Kiemeney, Lambertus A, Krakstad, Camilla, Kjaer, Susanne K, Kupryjanczyk, Jolanta, Lambrechts, Diether, Lambrechts, Sandrina, Le, Nhu D, Lee, Alice W, Lele, Shashi, Leminen, Arto, Lester, Jenny, Levine, Douglas A, Liang, Dong, Lissowska, Jolanta, Lu, Karen, Lubinski, Jan, Lundvall, Lene, Massuger, Leon FAG, Matsuo, Keitaro, McGuire, Valerie, McLaughlin, John R, McNeish, Iain, Menon, Usha, Modugno, Francesmary, Moes-Sosnowska, Joanna, Moysich, Kirsten B, Narod, Steven A, and Nedergaard, Lotte

Subjects
Developmental Biology, Medical and Health Sciences, Biological Sciences
Published
2015

19. Cell-type-specific enrichment of risk-associated regulatory elements at ovarian cancer susceptibility loci

Author

Coetzee, Simon G, Shen, Howard C, Hazelett, Dennis J, Lawrenson, Kate, Kuchenbaecker, Karoline, Tyrer, Jonathan, Rhie, Suhn K, Levanon, Keren, Karst, Alison, Drapkin, Ronny, Ramus, Susan J, Consortium, The Consortium of Investigators of Modifiers of BRCA1 2 The Ovarian Cancer Association, Couch, Fergus J, Offit, Kenneth, Chenevix-Trench, Georgia, Monteiro, Alvaro NA, Antoniou, Antonis, Freedman, Matthew, Coetzee, Gerhard A, Pharoah, Paul DP, Noushmehr, Houtan, Gayther, Simon A, Anton-Culver, Hoda, Antonenkova, Natalia, Baker, Helen, Bandera, Elisa V, Bean, Yukie, Beckmann, Matthias W, Berchuck, Andrew, Bisogna, Maria, Bjorge, Line, Bogdanova, Natalia, Brinton, Louise A, Brooks-Wilson, Angela, Bruinsma, Fiona, Butzow, Ralf, Campbell, Ian G, Carty, Karen, Chang-Claude, Jenny, Chen, Ann, Chen, Zhihua, Cook, Linda S, Cramer, Daniel W, Cunningham, Julie M, Cybulski, Cezary, Dansonka-Mieszkowska, Agnieszka, Dennis, Joe, Dicks, Ed, Doherty, Jennifer A, Dörk, Thilo, du Bois, Andreas, Dürst, Matthias, Eccles, Diana, Easton, Douglas F, Edwards, Robert P, Eilber, Ursula, Ekici, Arif B, Fasching, Peter A, Fridley, Brooke L, Gao, Yu-Tang, Gentry-Maharaj, Aleksandra, Giles, Graham G, Glasspool, Rosalind, Goode, Ellen L, Goodman, Marc T, Grownwald, Jacek, Harrington, Patricia, Harter, Philipp, Hasmad, Hanis Nazihah, Hein, Alexander, Heitz, Florian, Hildebrandt, Michelle AT, Hillemanns, Peter, Hogdall, Estrid, Hogdall, Claus, Hosono, Satoyo, Iversen, Edwin S, Jakubowska, Anna, James, Paul, Jensen, Allan, Ji, Bu-Tian, Karlan, Beth Y, Kjaer, Susanne Kruger, Kelemen, Linda E, Kellar, Melissa, Kelley, Joseph L, Kiemeney, Lambertus A, Krakstad, Camilla, Kupryjanczyk, Jolanta, Lambrechts, Diether, Lambrechts, Sandrina, Le, Nhu D, Lele, Shashi, Leminen, Arto, Lester, Jenny, Levine, Douglas A, Liang, Dong, and Lissowska, Jolanta

Subjects
Biological Sciences, Genetics, Rare Diseases, Women's Health, Cancer Genomics, Ovarian Cancer, Human Genome, Cancer, Prevention, 2.1 Biological and endogenous factors, Chromatin, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Histones, Humans, Organ Specificity, Ovarian Neoplasms, Polymorphism, Single Nucleotide, Regulatory Sequences, Nucleic Acid, Ovarian Cancer Association Consortium, The Consortium of Investigators of Modifiers of BRCA1/2, Ovarian Cancer Association Consortium The Consortium of Investigators of Modifiers of BRCA1/2, Medical and Health Sciences, Genetics & Heredity
Abstract

Understanding the regulatory landscape of the human genome is a central question in complex trait genetics. Most single-nucleotide polymorphisms (SNPs) associated with cancer risk lie in non-protein-coding regions, implicating regulatory DNA elements as functional targets of susceptibility variants. Here, we describe genome-wide annotation of regions of open chromatin and histone modification in fallopian tube and ovarian surface epithelial cells (FTSECs, OSECs), the debated cellular origins of high-grade serous ovarian cancers (HGSOCs) and in endometriosis epithelial cells (EECs), the likely precursor of clear cell ovarian carcinomas (CCOCs). The regulatory architecture of these cell types was compared with normal human mammary epithelial cells and LNCaP prostate cancer cells. We observed similar positional patterns of global enhancer signatures across the three different ovarian cancer precursor cell types, and evidence of tissue-specific regulatory signatures compared to non-gynecological cell types. We found significant enrichment for risk-associated SNPs intersecting regulatory biofeatures at 17 known HGSOC susceptibility loci in FTSECs (P = 3.8 × 10(-30)), OSECs (P = 2.4 × 10(-23)) and HMECs (P = 6.7 × 10(-15)) but not for EECs (P = 0.45) or LNCaP cells (P = 0.88). Hierarchical clustering of risk SNPs conditioned on the six different cell types indicates FTSECs and OSECs are highly related (96% of samples using multi-scale bootstrapping) suggesting both cell types may be precursors of HGSOC. These data represent the first description of regulatory catalogues of normal precursor cells for different ovarian cancer subtypes, and provide unique insights into the tissue specific regulatory variation with respect to the likely functional targets of germline genetic susceptibility variants for ovarian cancer.

Published
2015

20. Characterization of the humoral immune response to the EBV proteome in extranodal NK/T-cell lymphoma

Author

Liu, Zhiwei, Sarathkumara, Yomani D., Chan, John K. C., Kwong, Yok-Lam, Lam, Tai Hing, Ip, Dennis Kai Ming, Chiu, Brian C.-H., Xu, Jun, Su, Yu-Chieh, Proietti, Carla, Cooper, Martha M., Yu, Kelly J., Bassig, Bryan, Liang, Raymond, Hu, Wei, Ji, Bu-Tian, Coghill, Anna E., Pfeiffer, Ruth M., Hildesheim, Allan, Rothman, Nathaniel, Doolan, Denise L., and Lan, Qing

Published
2021
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21. Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk

Author

Chornokur, Ganna, Lin, Hui-Yi, Tyrer, Jonathan P, Lawrenson, Kate, Dennis, Joe, Amankwah, Ernest K, Qu, Xiaotao, Tsai, Ya-Yu, Jim, Heather SL, Chen, Zhihua, Chen, Ann Y, Permuth-Wey, Jennifer, Aben, Katja KH, Anton-Culver, Hoda, Antonenkova, Natalia, Bruinsma, Fiona, Bandera, Elisa V, Bean, Yukie T, Beckmann, Matthias W, Bisogna, Maria, Bjorge, Line, Bogdanova, Natalia, Brinton, Louise A, Brooks-Wilson, Angela, Bunker, Clareann H, Butzow, Ralf, Campbell, Ian G, Carty, Karen, Chang-Claude, Jenny, Cook, Linda S, Cramer, Daniel W, Cunningham, Julie M, Cybulski, Cezary, Dansonka-Mieszkowska, Agnieszka, du Bois, Andreas, Despierre, Evelyn, Dicks, Ed, Doherty, Jennifer A, Dörk, Thilo, Dürst, Matthias, Easton, Douglas F, Eccles, Diana M, Edwards, Robert P, Ekici, Arif B, Fasching, Peter A, Fridley, Brooke L, Gao, Yu-Tang, Gentry-Maharaj, Aleksandra, Giles, Graham G, Glasspool, Rosalind, Goodman, Marc T, Gronwald, Jacek, Harrington, Patricia, Harter, Philipp, Hein, Alexander, Heitz, Florian, Hildebrandt, Michelle AT, Hillemanns, Peter, Hogdall, Claus K, Hogdall, Estrid, Hosono, Satoyo, Jakubowska, Anna, Jensen, Allan, Ji, Bu-Tian, Karlan, Beth Y, Kelemen, Linda E, Kellar, Mellissa, Kiemeney, Lambertus A, Krakstad, Camilla, Kjaer, Susanne K, Kupryjanczyk, Jolanta, Lambrechts, Diether, Lambrechts, Sandrina, Le, Nhu D, Lee, Alice W, Lele, Shashi, Leminen, Arto, Lester, Jenny, Levine, Douglas A, Liang, Dong, Lim, Boon Kiong, Lissowska, Jolanta, Lu, Karen, Lubinski, Jan, Lundvall, Lene, Massuger, Leon FAG, Matsuo, Keitaro, McGuire, Valerie, McLaughlin, John R, McNeish, Iain, Menon, Usha, Milne, Roger L, Modugno, Francesmary, Moysich, Kirsten B, Ness, Roberta B, Nevanlinna, Heli, Eilber, Ursula, Odunsi, Kunle, Olson, Sara H, and Orlow, Irene

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Genetics, Ovarian Cancer, Cancer, Women's Health, Rare Diseases, 2.1 Biological and endogenous factors, Black or African American, Alleles, Asian, Biological Transport, Carcinoma, Ovarian Epithelial, Carrier Proteins, Case-Control Studies, Female, Genetic Association Studies, Genetic Predisposition to Disease, Genetic Variation, Humans, Neoplasms, Glandular and Epithelial, Odds Ratio, Ovarian Neoplasms, Polymorphism, Single Nucleotide, Risk, Georgia Chenevix-Trench, AOCS management group, General Science & Technology
Abstract

BackgroundDefective cellular transport processes can lead to aberrant accumulation of trace elements, iron, small molecules and hormones in the cell, which in turn may promote the formation of reactive oxygen species, promoting DNA damage and aberrant expression of key regulatory cancer genes. As DNA damage and uncontrolled proliferation are hallmarks of cancer, including epithelial ovarian cancer (EOC), we hypothesized that inherited variation in the cellular transport genes contributes to EOC risk.MethodsIn total, DNA samples were obtained from 14,525 case subjects with invasive EOC and from 23,447 controls from 43 sites in the Ovarian Cancer Association Consortium (OCAC). Two hundred seventy nine SNPs, representing 131 genes, were genotyped using an Illumina Infinium iSelect BeadChip as part of the Collaborative Oncological Gene-environment Study (COGS). SNP analyses were conducted using unconditional logistic regression under a log-additive model, and the FDR q

Published
2015

22. Common Genetic Variation in Circadian Rhythm Genes and Risk of Epithelial Ovarian Cancer (EOC)

Author

Jim, Heather SL, Lin, Hui-Yi, Tyrer, Jonathan P, Lawrenson, Kate, Dennis, Joe, Chornokur, Ganna, Chen, Zhihua, Chen, Ann Y, Permuth-Wey, Jennifer, Aben, Katja KH, Anton-Culver, Hoda, Antonenkova, Natalia, Bruinsma, Fiona, Bandera, Elisa V, Bean, Yukie T, Beckmann, Matthias W, Bisogna, Maria, Bjorge, Line, Bogdanova, Natalia, Brinton, Louise A, Brooks-Wilson, Angela, Bunker, Clareann H, Butzow, Ralf, Campbell, Ian G, Carty, Karen, Chang-Claude, Jenny, Cook, Linda S, Cramer, Daniel W, Cunningham, Julie M, Cybulski, Cezary, Dansonka-Mieszkowska, Agnieszka, du Bois, Andreas, Despierre, Evelyn, Sieh, Weiva, Doherty, Jennifer A, Dörk, Thilo, Dürst, Matthias, Easton, Douglas F, Eccles, Diana M, Edwards, Robert P, Ekici, Arif B, Fasching, Peter A, Fridley, Brooke L, Gao, Yu-Tang, Gentry-Maharaj, Aleksandra, Giles, Graham G, Glasspool, Rosalind, Goodman, Marc T, Gronwald, Jacek, Harter, Philipp, Hasmad, Hanis N, Hein, Alexander, Heitz, Florian, Hildebrandt, Michelle AT, Hillemanns, Peter, Hogdall, Claus K, Hogdall, Estrid, Hosono, Satoyo, Iversen, Edwin S, Jakubowska, Anna, Jensen, Allan, Ji, Bu-Tian, Karlan, Beth Y, Kellar, Melissa, Kiemeney, Lambertus A, Krakstad, Camilla, Kjaer, Susanne K, Kupryjanczyk, Jolanta, Vierkant, Robert A, Lambrechts, Diether, Lambrechts, Sandrina, Le, Nhu D, Lee, Alice W, Lele, Shashi, Leminen, Arto, Lester, Jenny, Levine, Douglas A, Liang, Dong, Lim, Boon Kiong, Lissowska, Jolanta, Lu, Karen, Lubinski, Jan, Lundvall, Lene, Massuger, Leon FAG, Matsuo, Keitaro, McGuire, Valerie, McLaughlin, John R, McNeish, Ian, Menon, Usha, Milne, Roger L, Modugno, Francesmary, Thomsen, Lotte, Moysich, Kirsten B, Ness, Roberta B, Nevanlinna, Heli, Eilber, Ursula, Odunsi, Kunle, Olson, Sara H, Orlow, Irene, and Orsulic, Sandra

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Health Services and Systems, Health Sciences, Oncology and Carcinogenesis, Cancer, Women's Health, Ovarian Cancer, Prevention, Rare Diseases, Sleep Research, Human Genome, Genetic Testing, 2.1 Biological and endogenous factors, Georgia Chenevix-Trench on behalf of the AOCS management group 95, 96
Abstract

Disruption in circadian gene expression, whether due to genetic variation or environmental factors (e.g., light at night, shiftwork), is associated with increased incidence of breast, prostate, gastrointestinal and hematologic cancers and gliomas. Circadian genes are highly expressed in the ovaries where they regulate ovulation; circadian disruption is associated with several ovarian cancer risk factors (e.g., endometriosis). However, no studies have examined variation in germline circadian genes as predictors of ovarian cancer risk and invasiveness. The goal of the current study was to examine single nucleotide polymorphisms (SNPs) in circadian genes BMAL1, CRY2, CSNK1E, NPAS2, PER3, REV1 and TIMELESS and downstream transcription factors KLF10 and SENP3 as predictors of risk of epithelial ovarian cancer (EOC) and histopathologic subtypes. The study included a test set of 3,761 EOC cases and 2,722 controls and a validation set of 44,308 samples including 18,174 (10,316 serous) cases and 26,134 controls from 43 studies participating in the Ovarian Cancer Association Consortium (OCAC). Analysis of genotype data from 36 genotyped SNPs and 4600 imputed SNPs indicated that the most significant association was rs117104877 in BMAL1 (OR = 0.79, 95% CI = 0.68-0.90, p = 5.59 × 10-4]. Functional analysis revealed a significant down regulation of BMAL1 expression following cMYC overexpression and increasing transformation in ovarian surface epithelial (OSE) cells as well as alternative splicing of BMAL1 exons in ovarian and granulosa cells. These results suggest that variation in circadian genes, and specifically BMAL1, may be associated with risk of ovarian cancer, likely through disruption of hormonal pathways.

Published
2015

23. Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index

Author

Wen, Wanqing, Zheng, Wei, Okada, Yukinori, Takeuchi, Fumihiko, Tabara, Yasuharu, Hwang, Joo-Yeon, Dorajoo, Rajkumar, Li, Huaixing, Tsai, Fuu-Jen, Yang, Xiaobo, He, Jiang, Wu, Ying, He, Meian, Zhang, Yi, Liang, Jun, Guo, Xiuqing, Sheu, Wayne Huey-Herng, Delahanty, Ryan, Guo, Xingyi, Kubo, Michiaki, Yamamoto, Ken, Ohkubo, Takayoshi, Go, Min Jin, Liu, Jian Jun, Gan, Wei, Chen, Ching-Chu, Gao, Yong, Li, Shengxu, Lee, Nanette R, Wu, Chen, Zhou, Xueya, Song, Huaidong, Yao, Jie, Lee, I-Te, Long, Jirong, Tsunoda, Tatsuhiko, Akiyama, Koichi, Takashima, Naoyuki, Cho, Yoon Shin, Ong, Rick TH, Lu, Ling, Chen, Chien-Hsiun, Tan, Aihua, Rice, Treva K, Adair, Linda S, Gui, Lixuan, Allison, Matthew, Lee, Wen-Jane, Cai, Qiuyin, Isomura, Minoru, Umemura, Satoshi, Kim, Young Jin, Seielstad, Mark, Hixson, James, Xiang, Yong-Bing, Isono, Masato, Kim, Bong-Jo, Sim, Xueling, Lu, Wei, Nabika, Toru, Lee, Juyoung, Lim, Wei-Yen, Gao, Yu-Tang, Takayanagi, Ryoichi, Kang, Dae-Hee, Wong, Tien Yin, Hsiung, Chao Agnes, Wu, I-Chien, Juang, Jyh-Ming Jimmy, Shi, Jiajun, Choi, Bo Youl, Aung, Tin, Hu, Frank, Kim, Mi Kyung, Lim, Wei Yen, Wang, Tzung-Dao, Shin, Min-Ho, Lee, Jeannette, Ji, Bu-Tian, Lee, Young-Hoon, Young, Terri L, Shin, Dong Hoon, Chun, Byung-Yeol, Cho, Myeong-Chan, Han, Bok-Ghee, Hwu, Chii-Min, Assimes, Themistocles L, Absher, Devin, Yan, Xiaofei, Kim, Eric, Kuo, Jane Z, Kwon, Soonil, Taylor, Kent D, Chen, Yii-Der I, Rotter, Jerome I, Qi, Lu, Zhu, Dingliang, Wu, Tangchun, Mohlke, Karen L, and Gu, Dongfeng

Subjects
Biological Sciences, Genetics, Obesity, Human Genome, Nutrition, Women's Health, 1.1 Normal biological development and functioning, Stroke, 5'-Nucleotidase, Aldehyde Dehydrogenase, Aldehyde Dehydrogenase, Mitochondrial, Asian People, Blood Proteins, Body Mass Index, Cardiac Myosins, Asia, Eastern, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Glycoproteins, Humans, KCNQ1 Potassium Channel, Male, Myosin Light Chains, Polymorphism, Single Nucleotide, Proteinase Inhibitory Proteins, Secretory, Medical and Health Sciences, Genetics & Heredity
Abstract

Recent genetic association studies have identified 55 genetic loci associated with obesity or body mass index (BMI). The vast majority, 51 loci, however, were identified in European-ancestry populations. We conducted a meta-analysis of associations between BMI and ∼2.5 million genotyped or imputed single nucleotide polymorphisms among 86 757 individuals of Asian ancestry, followed by in silico and de novo replication among 7488-47 352 additional Asian-ancestry individuals. We identified four novel BMI-associated loci near the KCNQ1 (rs2237892, P = 9.29 × 10(-13)), ALDH2/MYL2 (rs671, P = 3.40 × 10(-11); rs12229654, P = 4.56 × 10(-9)), ITIH4 (rs2535633, P = 1.77 × 10(-10)) and NT5C2 (rs11191580, P = 3.83 × 10(-8)) genes. The association of BMI with rs2237892, rs671 and rs12229654 was significantly stronger among men than among women. Of the 51 BMI-associated loci initially identified in European-ancestry populations, we confirmed eight loci at the genome-wide significance level (P < 5.0 × 10(-8)) and an additional 14 at P < 1.0 × 10(-3) with the same direction of effect as reported previously. Findings from this analysis expand our knowledge of the genetic basis of obesity.

Published
2014

25. Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer

Author

Shen, Hui, Fridley, Brooke L, Song, Honglin, Lawrenson, Kate, Cunningham, Julie M, Ramus, Susan J, Cicek, Mine S, Tyrer, Jonathan, Stram, Douglas, Larson, Melissa C, Köbel, Martin, Ziogas, Argyrios, Zheng, Wei, Yang, Hannah P, Wu, Anna H, Wozniak, Eva L, Ling Woo, Yin, Winterhoff, Boris, Wik, Elisabeth, Whittemore, Alice S, Wentzensen, Nicolas, Palmieri Weber, Rachel, Vitonis, Allison F, Vincent, Daniel, Vierkant, Robert A, Vergote, Ignace, Van Den Berg, David, Van Altena, Anne M, Tworoger, Shelley S, Thompson, Pamela J, Tessier, Daniel C, Terry, Kathryn L, Teo, Soo-Hwang, Templeman, Claire, Stram, Daniel O, Southey, Melissa C, Sieh, Weiva, Siddiqui, Nadeem, Shvetsov, Yurii B, Shu, Xiao-Ou, Shridhar, Viji, Wang-Gohrke, Shan, Severi, Gianluca, Schwaab, Ira, Salvesen, Helga B, Rzepecka, Iwona K, Runnebaum, Ingo B, Anne Rossing, Mary, Rodriguez-Rodriguez, Lorna, Risch, Harvey A, Renner, Stefan P, Poole, Elizabeth M, Pike, Malcolm C, Phelan, Catherine M, Pelttari, Liisa M, Pejovic, Tanja, Paul, James, Orlow, Irene, Zawiah Omar, Siti, Olson, Sara H, Odunsi, Kunle, Nickels, Stefan, Nevanlinna, Heli, Ness, Roberta B, Narod, Steven A, Nakanishi, Toru, Moysich, Kirsten B, Monteiro, Alvaro NA, Moes-Sosnowska, Joanna, Modugno, Francesmary, Menon, Usha, McLaughlin, John R, McGuire, Valerie, Matsuo, Keitaro, Mat Adenan, Noor Azmi, Massuger, Leon FAG, Lurie, Galina, Lundvall, Lene, Lubiński, Jan, Lissowska, Jolanta, Levine, Douglas A, Leminen, Arto, Lee, Alice W, Le, Nhu D, Lambrechts, Sandrina, Lambrechts, Diether, Kupryjanczyk, Jolanta, Krakstad, Camilla, Konecny, Gottfried E, Krüger Kjaer, Susanne, Kiemeney, Lambertus A, Kelemen, Linda E, Keeney, Gary L, Karlan, Beth Y, Karevan, Rod, Kalli, Kimberly R, Kajiyama, Hiroaki, Ji, Bu-Tian, Jensen, Allan, and Jakubowska, Anna

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Oncology and Carcinogenesis, Cancer, Prevention, Rare Diseases, Human Genome, Ovarian Cancer, Cancer Genomics, Women's Health, 2.1 Biological and endogenous factors, DNA Methylation, Epigenesis, Genetic, Female, Gene Expression Profiling, Genetic Predisposition to Disease, Hepatocyte Nuclear Factor 1-beta, Humans, Ovarian Neoplasms, Polymorphism, Single Nucleotide, Promoter Regions, Genetic, PRACTICAL Consortium, Australian Ovarian Cancer Study Group, Australian Cancer Study
Abstract

HNF1B is overexpressed in clear cell epithelial ovarian cancer, and we observed epigenetic silencing in serous epithelial ovarian cancer, leading us to hypothesize that variation in this gene differentially associates with epithelial ovarian cancer risk according to histological subtype. Here we comprehensively map variation in HNF1B with respect to epithelial ovarian cancer risk and analyse DNA methylation and expression profiles across histological subtypes. Different single-nucleotide polymorphisms associate with invasive serous (rs7405776 odds ratio (OR)=1.13, P=3.1 × 10(-10)) and clear cell (rs11651755 OR=0.77, P=1.6 × 10(-8)) epithelial ovarian cancer. Risk alleles for the serous subtype associate with higher HNF1B-promoter methylation in these tumours. Unmethylated, expressed HNF1B, primarily present in clear cell tumours, coincides with a CpG island methylator phenotype affecting numerous other promoters throughout the genome. Different variants in HNF1B associate with risk of serous and clear cell epithelial ovarian cancer; DNA methylation and expression patterns are also notably distinct between these subtypes. These findings underscore distinct mechanisms driving different epithelial ovarian cancer histological subtypes.

Published
2013

27. Associations between Longer Leukocyte Telomere Length and Increased Lung Cancer Risk among Never Smokers in Urban China

Author

Wong, Jason Y.Y., primary, Shu, Xiao-Ou, additional, Hu, Wei, additional, Blechter, Batel, additional, Shi, Jianxin, additional, Wang, Kevin, additional, Cawthon, Richard, additional, Cai, Qiuyin, additional, Yang, Gong, additional, Rahman, Mohammad L., additional, Ji, Bu-tian, additional, Gao, Yutang, additional, Zheng, Wei, additional, Rothman, Nathaniel, additional, and Lan, Qing, additional

Published
2023
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30. Polygenic Risk Score and Lung Adenocarcinoma Risk Among Never-Smokers by EGFR Mutation Status: A Brief Report

Author

Blechter, Batel, Hsiung, Chao Agnes, Wang, Xiaoyu, Zhang, Haoyu, Seow, Wei Jie, Shi, Jianxin, Chatterjee, Nilanjan, Kim, Hee Nam, Wong, Maria Pik, Hong, Yun-Chul, Wong, Jason Y.Y., Dai, Juncheng, Hosgood, H. Dean, Wang, Zhaoming, Chang, I-Shou, Choi, Jiyeon, Wang, Jiucun, Song, Minsun, Hu, Wei, Zheng, Wei, Kim, Jin Hee, Zhou, Baosen, Albanes, Demetrius, Shin, Min-Ho, Chung, Lap Ping, An, She-Juan, Zheng, Hong, Yatabe, Yasushi, Zhang, Xu-Chao, Kim, Young Tae, Shu, Xiao-Ou, Kim, Young-Chul, Vermeulen, Roel C.H., Bassig, Bryan A, Chang, Jiang, Man Ho, James Chung, Ji, Bu-Tian, Kubo, Michiaki, Daigo, Yataro, Momozawa, Yukihide, Kamatani, Yoichiro, Honda, Takayuki, Kunitoh, Hideo, Watanabe, Shun-ichi, Miyagi, Yohei, Nakayama, Haruhiko, Matsumoto, Shingo, Tsuboi, Masahiro, Goto, Koichi, Yin, Zhihua, Takahashi, Atsushi, Goto, Akiteru, Minamiya, Yoshihiro, Shimizu, Kimihiro, Tanaka, Kazumi, Wu, Tangchun, Wei, Fusheng, Su, Jian, Kim, Yeul Hong, Oh, In-Jae, Fun Lee, Victor Ho, Su, Wu-Chou, Chen, Yuh-Min, Chang, Gee-Chen, Chen, Kuan-Yu, Huang, Ming-Shyan, Lin, Hsien-Chih, Seow, Adeline, Park, Jae Yong, Kweon, Sun-Seog, Chen, Chien-Jen, Gao, Yu-Tang, Wu, Chen, Qian, Biyun, Lu, Daru, Liu, Jianjun, Jeon, Hyo-Sung, Hsiao, Chin-Fu, Sung, Jae Sook, Tsai, Ying-Huang, Jung, Yoo Jin, Guo, Huan, Hu, Zhibin, Chen, Tzu-Yu, Burdett, Laurie, Yeager, Meredith, Hutchinson, Amy, Berndt, Sonja I., Wu, Wei, Wang, Junwen, Choi, Jin Eun, Park, Kyong Hwa, Sung, Sook Whan, Liu, Li, Kang, Chang Hyun, Chen, Chung-Hsing, Xu, Jun, Guan, Peng, Tan, Wen, Wang, Chih-Liang, Loon Sihoe, Alan Dart, Chen, Ying, Choi, Yi Young, Kim, Jun Suk, Yoon, Ho-Il, Cai, Qiuyin, Park, In Kyu, Xu, Ping, He, Qincheng, Chen, Chih-Yi, Wu, Junjie, Lim, Wei-Yen, Chen, Kun-Chieh, Chan, John K.C., Li, Jihua, Chen, Hongyan, Yu, Chong-Jen, Jin, Li, Fraumeni, Joseph F., Jr, Liu, Jie, Landi, Maria Teresa, Yamaji, Taiki, Yang, Yang, Hicks, Belynda, Wyatt, Kathleen, Li, Shengchao A., Ma, Hongxia, Song, Bao, Wang, Zhehai, Cheng, Sensen, Li, Xuelian, Ren, Yangwu, Iwasaki, Motoki, Zhu, Junjie, Jiang, Gening, Fei, Ke, Wu, Guoping, Chien, Li-Hsin, Tsai, Fang-Yu, Yu, Jinming, Stevens, Victoria L., Yang, Pan-Chyr, Lin, Dongxin, Chen, Kexin, Wu, Yi-Long, Matsuo, Keitaro, Rothman, Nathaniel, Shiraishi, Kouya, Shen, Hongbing, Chanock, Stephen J., Kohno, Takashi, and Lan, Qing

Published
2024
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31. Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk

Author

Baron, John A., Berndt, Sonja I., Bezieau, Stéphane, Brenner, Hermann, Caan, Bette J., Carlson, Christopher S., Casey, Graham, Chan, Andrew T., Chang-Claude, Jenny, Chanock, Stephen J., Conti, David V., Curtis, Keith, Duggan, David, Fuchs, Charles S., Gallinger, Steven, Giovannucci, Edward L., Gruber, Stephen B., Haile, Robert W., Harrison, Tabitha A., Hayes, Richard B., Hoffmeister, Michael, Hopper, John L., Hsu, Li, Hudson, Thomas J., Hunter, David J., Hutter, Carolyn M., Jackson, Rebecca D., Jenkins, Mark A., Jiao, Shuo, Küry, Sébastien, Le Marchand, Loic, Lemire, Mathieu, Lindor, Noralane M., Ma, Jing, Newcomb, Polly A., Peters, Ulrike, Potter, John D., Qu, Conghui, Schoen, Robert E., Schumacher, Fredrick R., Seminara, Daniela, Slattery, Martha L., Thibodeau, Stephen N., White, Emily, Zanke, Brent W., Blalock, Kendra, Campbell, Peter T., Edlund, Christopher K., Figueiredo, Jane, Gauderman, W. James, Gong, Jian, Green, Roger C., Harju, John F., Jacobs, Eric J., Li, Li, Lin, Yi, Manion, Frank J., Moreno, Victor, Mukherjee, Bhramar, Raskin, Leon, Severi, Gianluca, Stenzel, Stephanie L., Thomas, Duncan C., Zeng, Chenjie, Matsuda, Koichi, Jia, Wei-Hua, Chang, Jiang, Kweon, Sun-Seog, Xiang, Yong-Bing, Shin, Aesun, Jee, Sun Ha, Kim, Dong-Hyun, Zhang, Ben, Cai, Qiuyin, Guo, Xingyi, Long, Jirong, Wang, Nan, Courtney, Regina, Pan, Zhi-Zhong, Wu, Chen, Takahashi, Atsushi, Shin, Min-Ho, Matsuo, Keitaro, Matsuda, Fumihiko, Gao, Yu-Tang, Oh, Jae Hwan, Kim, Soriul, Jung, Keum Ji, Ahn, Yoon-Ok, Ren, Zefang, Li, Hong-Lan, Wu, Jie, Shi, Jiajun, Wen, Wanqing, Yang, Gong, Li, Bingshan, Ji, Bu-Tian, Kim, Hyeong-Rok, Jeong, Jin-Young, Park, Ji Won, Tajima, Kazuo, Cho, Sang-Hee, Kubo, Michiaki, Shu, Xiao-Ou, Lin, Dongxin, Zeng, Yi-Xin, and Zheng, Wei

Published
2016
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32. Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

Author

IRAS OH Epidemiology Chemical Agents, Shi, Jianxin, Shiraishi, Kouya, Choi, Jiyeon, Matsuo, Keitaro, Chen, Tzu-Yu, Dai, Juncheng, Hung, Rayjean J, Chen, Kexin, Shu, Xiao-Ou, Kim, Young Tae, Landi, Maria Teresa, Lin, Dongxin, Zheng, Wei, Yin, Zhihua, Zhou, Baosen, Song, Bao, Wang, Jiucun, Seow, Wei Jie, Song, Lei, Chang, I-Shou, Hu, Wei, Chien, Li-Hsin, Cai, Qiuyin, Hong, Yun-Chul, Kim, Hee Nam, Wu, Yi-Long, Wong, Maria Pik, Richardson, Brian Douglas, Funderburk, Karen M, Li, Shilan, Zhang, Tongwu, Breeze, Charles, Wang, Zhaoming, Blechter, Batel, Bassig, Bryan A, Kim, Jin Hee, Albanes, Demetrius, Wong, Jason Y Y, Shin, Min-Ho, Chung, Lap Ping, Yang, Yang, An, She-Juan, Zheng, Hong, Yatabe, Yasushi, Zhang, Xu-Chao, Kim, Young-Chul, Caporaso, Neil E, Chang, Jiang, Ho, James Chung Man, Kubo, Michiaki, Daigo, Yataro, Song, Minsun, Momozawa, Yukihide, Kamatani, Yoichiro, Kobayashi, Masashi, Okubo, Kenichi, Honda, Takayuki, Hosgood, Dean H, Kunitoh, Hideo, Patel, Harsh, Watanabe, Shun-Ichi, Miyagi, Yohei, Nakayama, Haruhiko, Matsumoto, Shingo, Horinouchi, Hidehito, Tsuboi, Masahiro, Hamamoto, Ryuji, Goto, Koichi, Ohe, Yuichiro, Takahashi, Atsushi, Goto, Akiteru, Minamiya, Yoshihiro, Hara, Megumi, Nishida, Yuichiro, Takeuchi, Kenji, Wakai, Kenji, Matsuda, Koichi, Murakami, Yoshinori, Shimizu, Kimihiro, Suzuki, Hiroyuki, Saito, Motonobu, Ohtaki, Yoichi, Tanaka, Kazumi, Wu, Tangchun, Wei, Fusheng, Dai, Hongji, Machiela, Mitchell J, Su, Jian, Kim, Yeul Hong, Oh, In-Jae, Lee, Victor Ho Fun, Chang, Gee-Chen, Tsai, Ying-Huang, Chen, Kuan-Yu, Huang, Ming-Shyan, Su, Wu-Chou, Chen, Yuh-Min, Seow, Adeline, Park, Jae Yong, Kweon, Sun-Seog, Chen, Kun-Chieh, Gao, Yu-Tang, Qian, Biyun, Wu, Chen, Lu, Daru, Liu, Jianjun, Schwartz, Ann G, Houlston, Richard, Spitz, Margaret R, Gorlov, Ivan P, Wu, Xifeng, Yang, Ping, Lam, Stephen, Tardon, Adonina, Chen, Chu, Bojesen, Stig E, Johansson, Mattias, Risch, Angela, Bickeböller, Heike, Ji, Bu-Tian, Wichmann, H-Erich, Christiani, David C, Rennert, Gadi, Arnold, Susanne, Brennan, Paul, McKay, James, Field, John K, Shete, Sanjay S, Le Marchand, Loic, Liu, Geoffrey, Andrew, Angeline, Kiemeney, Lambertus A, Zienolddiny-Narui, Shan, Grankvist, Kjell, Johansson, Mikael, Cox, Angela, Taylor, Fiona, Yuan, Jian-Min, Lazarus, Philip, Schabath, Matthew B, Aldrich, Melinda C, Jeon, Hyo-Sung, Jiang, Shih Sheng, Sung, Jae Sook, Chen, Chung-Hsing, Hsiao, Chin-Fu, Jung, Yoo Jin, Guo, Huan, Hu, Zhibin, Burdett, Laurie, Yeager, Meredith, Hutchinson, Amy, Hicks, Belynda, Liu, Jia, Zhu, Bin, Berndt, Sonja I, Wu, Wei, Wang, Junwen, Li, Yuqing, Choi, Jin Eun, Park, Kyong Hwa, Sung, Sook Whan, Liu, Li, Kang, Chang Hyun, Wang, Wen-Chang, Xu, Jun, Guan, Peng, Tan, Wen, Yu, Chong-Jen, Yang, Gong, Sihoe, Alan Dart Loon, Chen, Ying, Choi, Yi Young, Kim, Jun Suk, Yoon, Ho-Il, Park, In Kyu, Xu, Ping, He, Qincheng, Wang, Chih-Liang, Hung, Hsiao-Han, Vermeulen, Roel C H, Cheng, Iona, Wu, Junjie, Lim, Wei-Yen, Tsai, Fang-Yu, Chan, John K C, Li, Jihua, Chen, Hongyan, Lin, Hsien-Chih, Jin, Li, Liu, Jie, Sawada, Norie, Yamaji, Taiki, Wyatt, Kathleen, Li, Shengchao A, Ma, Hongxia, Zhu, Meng, Wang, Zhehai, Cheng, Sensen, Li, Xuelian, Ren, Yangwu, Chao, Ann, Iwasaki, Motoki, Zhu, Junjie, Jiang, Gening, Fei, Ke, Wu, Guoping, Chen, Chih-Yi, Chen, Chien-Jen, Yang, Pan-Chyr, Yu, Jinming, Stevens, Victoria L, Fraumeni, Joseph F, Chatterjee, Nilanjan, Gorlova, Olga Y, Hsiung, Chao Agnes, Amos, Christopher I, Shen, Hongbing, Chanock, Stephen J, Rothman, Nathaniel, Kohno, Takashi, Lan, Qing, IRAS OH Epidemiology Chemical Agents, Shi, Jianxin, Shiraishi, Kouya, Choi, Jiyeon, Matsuo, Keitaro, Chen, Tzu-Yu, Dai, Juncheng, Hung, Rayjean J, Chen, Kexin, Shu, Xiao-Ou, Kim, Young Tae, Landi, Maria Teresa, Lin, Dongxin, Zheng, Wei, Yin, Zhihua, Zhou, Baosen, Song, Bao, Wang, Jiucun, Seow, Wei Jie, Song, Lei, Chang, I-Shou, Hu, Wei, Chien, Li-Hsin, Cai, Qiuyin, Hong, Yun-Chul, Kim, Hee Nam, Wu, Yi-Long, Wong, Maria Pik, Richardson, Brian Douglas, Funderburk, Karen M, Li, Shilan, Zhang, Tongwu, Breeze, Charles, Wang, Zhaoming, Blechter, Batel, Bassig, Bryan A, Kim, Jin Hee, Albanes, Demetrius, Wong, Jason Y Y, Shin, Min-Ho, Chung, Lap Ping, Yang, Yang, An, She-Juan, Zheng, Hong, Yatabe, Yasushi, Zhang, Xu-Chao, Kim, Young-Chul, Caporaso, Neil E, Chang, Jiang, Ho, James Chung Man, Kubo, Michiaki, Daigo, Yataro, Song, Minsun, Momozawa, Yukihide, Kamatani, Yoichiro, Kobayashi, Masashi, Okubo, Kenichi, Honda, Takayuki, Hosgood, Dean H, Kunitoh, Hideo, Patel, Harsh, Watanabe, Shun-Ichi, Miyagi, Yohei, Nakayama, Haruhiko, Matsumoto, Shingo, Horinouchi, Hidehito, Tsuboi, Masahiro, Hamamoto, Ryuji, Goto, Koichi, Ohe, Yuichiro, Takahashi, Atsushi, Goto, Akiteru, Minamiya, Yoshihiro, Hara, Megumi, Nishida, Yuichiro, Takeuchi, Kenji, Wakai, Kenji, Matsuda, Koichi, Murakami, Yoshinori, Shimizu, Kimihiro, Suzuki, Hiroyuki, Saito, Motonobu, Ohtaki, Yoichi, Tanaka, Kazumi, Wu, Tangchun, Wei, Fusheng, Dai, Hongji, Machiela, Mitchell J, Su, Jian, Kim, Yeul Hong, Oh, In-Jae, Lee, Victor Ho Fun, Chang, Gee-Chen, Tsai, Ying-Huang, Chen, Kuan-Yu, Huang, Ming-Shyan, Su, Wu-Chou, Chen, Yuh-Min, Seow, Adeline, Park, Jae Yong, Kweon, Sun-Seog, Chen, Kun-Chieh, Gao, Yu-Tang, Qian, Biyun, Wu, Chen, Lu, Daru, Liu, Jianjun, Schwartz, Ann G, Houlston, Richard, Spitz, Margaret R, Gorlov, Ivan P, Wu, Xifeng, Yang, Ping, Lam, Stephen, Tardon, Adonina, Chen, Chu, Bojesen, Stig E, Johansson, Mattias, Risch, Angela, Bickeböller, Heike, Ji, Bu-Tian, Wichmann, H-Erich, Christiani, David C, Rennert, Gadi, Arnold, Susanne, Brennan, Paul, McKay, James, Field, John K, Shete, Sanjay S, Le Marchand, Loic, Liu, Geoffrey, Andrew, Angeline, Kiemeney, Lambertus A, Zienolddiny-Narui, Shan, Grankvist, Kjell, Johansson, Mikael, Cox, Angela, Taylor, Fiona, Yuan, Jian-Min, Lazarus, Philip, Schabath, Matthew B, Aldrich, Melinda C, Jeon, Hyo-Sung, Jiang, Shih Sheng, Sung, Jae Sook, Chen, Chung-Hsing, Hsiao, Chin-Fu, Jung, Yoo Jin, Guo, Huan, Hu, Zhibin, Burdett, Laurie, Yeager, Meredith, Hutchinson, Amy, Hicks, Belynda, Liu, Jia, Zhu, Bin, Berndt, Sonja I, Wu, Wei, Wang, Junwen, Li, Yuqing, Choi, Jin Eun, Park, Kyong Hwa, Sung, Sook Whan, Liu, Li, Kang, Chang Hyun, Wang, Wen-Chang, Xu, Jun, Guan, Peng, Tan, Wen, Yu, Chong-Jen, Yang, Gong, Sihoe, Alan Dart Loon, Chen, Ying, Choi, Yi Young, Kim, Jun Suk, Yoon, Ho-Il, Park, In Kyu, Xu, Ping, He, Qincheng, Wang, Chih-Liang, Hung, Hsiao-Han, Vermeulen, Roel C H, Cheng, Iona, Wu, Junjie, Lim, Wei-Yen, Tsai, Fang-Yu, Chan, John K C, Li, Jihua, Chen, Hongyan, Lin, Hsien-Chih, Jin, Li, Liu, Jie, Sawada, Norie, Yamaji, Taiki, Wyatt, Kathleen, Li, Shengchao A, Ma, Hongxia, Zhu, Meng, Wang, Zhehai, Cheng, Sensen, Li, Xuelian, Ren, Yangwu, Chao, Ann, Iwasaki, Motoki, Zhu, Junjie, Jiang, Gening, Fei, Ke, Wu, Guoping, Chen, Chih-Yi, Chen, Chien-Jen, Yang, Pan-Chyr, Yu, Jinming, Stevens, Victoria L, Fraumeni, Joseph F, Chatterjee, Nilanjan, Gorlova, Olga Y, Hsiung, Chao Agnes, Amos, Christopher I, Shen, Hongbing, Chanock, Stephen J, Rothman, Nathaniel, Kohno, Takashi, and Lan, Qing

Published
2023

33. Alterations to biomarkers related to long-term exposure to diesel exhaust at concentrations below occupational exposure limits in the European Union and the USA

Author

IRAS OH Epidemiology Chemical Agents, Wong, Jason Yy, Blechter, Batel, Bassig, Bryan A, Dai, Yufei, Vermeulen, Roel, Hu, Wei, Rahman, Mohammad L, Duan, Huawei, Niu, Yong, Downward, George S, Leng, Shuguang, Ji, Bu-Tian, Fu, Wei, Xu, Jun, Meliefste, Kees, Zhou, Baosen, Yang, Jufang, Ren, Dianzhi, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Hosgood, H Dean, Rothman, Nathaniel, Silverman, Debra T, Zheng, Yuxin, Lan, Qing, IRAS OH Epidemiology Chemical Agents, Wong, Jason Yy, Blechter, Batel, Bassig, Bryan A, Dai, Yufei, Vermeulen, Roel, Hu, Wei, Rahman, Mohammad L, Duan, Huawei, Niu, Yong, Downward, George S, Leng, Shuguang, Ji, Bu-Tian, Fu, Wei, Xu, Jun, Meliefste, Kees, Zhou, Baosen, Yang, Jufang, Ren, Dianzhi, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Hosgood, H Dean, Rothman, Nathaniel, Silverman, Debra T, Zheng, Yuxin, and Lan, Qing

Published
2023

34. Methylated polycyclic aromatic hydrocarbons from household coal use across the life course and risk of lung cancer in a large cohort of 42,420 subjects in Xuanwei, China

Author

IRAS OH Epidemiology Chemical Agents, Portengen, Lützen, Downward, George, Bassig, Bryan A, Blechter, Batel, Hu, Wei, Wong, Jason Y Y, Ning, Bofu, Rahman, Mohammad L, Ji, Bu-Tian, Li, Jihua, Yang, Kaiyun, Hosgood, H Dean, Silverman, Debra T, Rothman, Nathaniel, Huang, Yunchao, Vermeulen, Roel, Lan, Qing, IRAS OH Epidemiology Chemical Agents, Portengen, Lützen, Downward, George, Bassig, Bryan A, Blechter, Batel, Hu, Wei, Wong, Jason Y Y, Ning, Bofu, Rahman, Mohammad L, Ji, Bu-Tian, Li, Jihua, Yang, Kaiyun, Hosgood, H Dean, Silverman, Debra T, Rothman, Nathaniel, Huang, Yunchao, Vermeulen, Roel, and Lan, Qing

Published
2023

35. Exposure to smoky coal combustion emissions and leukocyte Alu retroelement copy number

Author

IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Blechter, Batel, Wong, Jason Y Y, Hu, Wei, Cawthon, Richard, Downward, George S, Portengen, Lützen, Zhang, Yongliang, Ning, Bofu, Rahman, Mohammad L, Ji, Bu-Tian, Li, Jihua, Yang, Kaiyun, Hosgood, H Dean, Silverman, Debra T, Huang, Yunchao, Rothman, Nathaniel, Vermeulen, Roel, Lan, Qing, IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Blechter, Batel, Wong, Jason Y Y, Hu, Wei, Cawthon, Richard, Downward, George S, Portengen, Lützen, Zhang, Yongliang, Ning, Bofu, Rahman, Mohammad L, Ji, Bu-Tian, Li, Jihua, Yang, Kaiyun, Hosgood, H Dean, Silverman, Debra T, Huang, Yunchao, Rothman, Nathaniel, Vermeulen, Roel, and Lan, Qing

Published
2023

36. Household air pollution and epigenetic aging in Xuanwei, China

Author

IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Blechter, Batel, Cardenas, Andres, Shi, Junming, Wong, Jason Y Y, Hu, Wei, Rahman, Mohammad L, Breeze, Charles, Downward, George S, Portengen, Lützen, Zhang, Yongliang, Ning, Bofu, Ji, Bu-Tian, Cawthon, Richard, Li, Jihua, Yang, Kaiyun, Bozack, Anne, Dean Hosgood, H, Silverman, Debra T, Huang, Yunchao, Rothman, Nathaniel, Vermeulen, Roel, Lan, Qing, IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Blechter, Batel, Cardenas, Andres, Shi, Junming, Wong, Jason Y Y, Hu, Wei, Rahman, Mohammad L, Breeze, Charles, Downward, George S, Portengen, Lützen, Zhang, Yongliang, Ning, Bofu, Ji, Bu-Tian, Cawthon, Richard, Li, Jihua, Yang, Kaiyun, Bozack, Anne, Dean Hosgood, H, Silverman, Debra T, Huang, Yunchao, Rothman, Nathaniel, Vermeulen, Roel, and Lan, Qing

Published
2023

37. Exposure to smoky coal combustion emissions and leukocyte Alu retroelement copy number

Author

Planetary Health & Exposoom, Blechter, Batel, Wong, Jason Y Y, Hu, Wei, Cawthon, Richard, Downward, George S, Portengen, Lützen, Zhang, Yongliang, Ning, Bofu, Rahman, Mohammad L, Ji, Bu-Tian, Li, Jihua, Yang, Kaiyun, Dean Hosgood, H, Silverman, Debra T, Huang, Yunchao, Rothman, Nathaniel, Vermeulen, Roel, Lan, Qing, Planetary Health & Exposoom, Blechter, Batel, Wong, Jason Y Y, Hu, Wei, Cawthon, Richard, Downward, George S, Portengen, Lützen, Zhang, Yongliang, Ning, Bofu, Rahman, Mohammad L, Ji, Bu-Tian, Li, Jihua, Yang, Kaiyun, Dean Hosgood, H, Silverman, Debra T, Huang, Yunchao, Rothman, Nathaniel, Vermeulen, Roel, and Lan, Qing

Published
2023

38. Exposure to smoky coal combustion emissions and leukocyte Alu retroelement copy number

Author

Blechter, Batel, primary, Wong, Jason Y Y, additional, Hu, Wei, additional, Cawthon, Richard, additional, Downward, George S, additional, Portengen, Lützen, additional, Zhang, Yongliang, additional, Ning, Bofu, additional, Rahman, Mohammad L, additional, Ji, Bu-Tian, additional, Li, Jihua, additional, Yang, Kaiyun, additional, Hosgood, H Dean, additional, Silverman, Debra T, additional, Huang, Yunchao, additional, Rothman, Nathaniel, additional, Vermeulen, Roel, additional, and Lan, Qing, additional

Published
2023
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39. Abstract 6056: A nested case-control study of untargeted plasma metabolomics and lung cancer risk among never-smoking women in the prospective Shanghai Women’s Health Study

Author

Rahman, Mohammad L., primary, Shu, Xiao-Ou, additional, Walker, Douglas, additional, Jones, Dean P., additional, Hu, Wei, additional, Ji, Bu-tian, additional, Blechter, Batel, additional, Wong, Jason YY, additional, Cai, Qiuyin, additional, Yang, Gong, additional, Gao, Tu-Tang, additional, Zheng, Wei, additional, Rothman, Nathaniel, additional, and Lan, Qing, additional

Published
2023
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40. Abstract 3483: Epigenome-wide association study of lung cancer among never-smokers in two prospective cohorts in Shanghai

Author

Rahman, Mohammad L., primary, Breeze, Charles E., additional, Shu, Xiao-Ou, additional, Wong, Jason YY, additional, Cardenas, Andres, additional, Wang, Xuting, additional, Ji, Bu-Tian, additional, Hu, Wei, additional, Blechter, Batel, additional, Cai, Qiuyin, additional, Hosgood, H Dean, additional, Yang, Gong, additional, Shi, Jianxin, additional, Long, Jirong, additional, Gao, Yu-Tang, additional, Bell, Douglas, additional, Zheng, Wei, additional, Lan, Qing, additional, and Rothman, Nathaniel, additional

Published
2023
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41. Data from Sleep Duration across the Adult Lifecourse and Risk of Lung Cancer Mortality: A Cohort Study in Xuanwei, China

Author

Wong, Jason Y., primary, Bassig, Bryan A., primary, Vermeulen, Roel, primary, Hu, Wei, primary, Ning, Bofu, primary, Seow, Wei Jie, primary, Ji, Bu-Tian, primary, Downward, George S., primary, Katki, Hormuzd A., primary, Barone-Adesi, Francesco, primary, Rothman, Nathaniel, primary, Chapman, Robert S., primary, and Lan, Qing, primary

Published
2023
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42. Supplementary Tables 1, 2, 3, 4 from Sleep Duration across the Adult Lifecourse and Risk of Lung Cancer Mortality: A Cohort Study in Xuanwei, China

Author

Wong, Jason Y., primary, Bassig, Bryan A., primary, Vermeulen, Roel, primary, Hu, Wei, primary, Ning, Bofu, primary, Seow, Wei Jie, primary, Ji, Bu-Tian, primary, Downward, George S., primary, Katki, Hormuzd A., primary, Barone-Adesi, Francesco, primary, Rothman, Nathaniel, primary, Chapman, Robert S., primary, and Lan, Qing, primary

Published
2023
Full Text
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43. Supplementary Figure 3 from Metabolomics in Epidemiology: Sources of Variability in Metabolite Measurements and Implications

Author

Sampson, Joshua N., primary, Boca, Simina M., primary, Shu, Xiao Ou, primary, Stolzenberg-Solomon, Rachael Z., primary, Matthews, Charles E., primary, Hsing, Ann W., primary, Tan, Yu Ting, primary, Ji, Bu-Tian, primary, Chow, Wong-Ho, primary, Cai, Qiuyin, primary, Liu, Da Ke, primary, Yang, Gong, primary, Xiang, Yong Bing, primary, Zheng, Wei, primary, Sinha, Rashmi, primary, Cross, Amanda J., primary, and Moore, Steven C., primary

Published
2023
Full Text
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44. Data from Metabolomics in Epidemiology: Sources of Variability in Metabolite Measurements and Implications

Author

Sampson, Joshua N., primary, Boca, Simina M., primary, Shu, Xiao Ou, primary, Stolzenberg-Solomon, Rachael Z., primary, Matthews, Charles E., primary, Hsing, Ann W., primary, Tan, Yu Ting, primary, Ji, Bu-Tian, primary, Chow, Wong-Ho, primary, Cai, Qiuyin, primary, Liu, Da Ke, primary, Yang, Gong, primary, Xiang, Yong Bing, primary, Zheng, Wei, primary, Sinha, Rashmi, primary, Cross, Amanda J., primary, and Moore, Steven C., primary

Published
2023
Full Text
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45. Data from Pathway Analyses Identify TGFBR2 as Potential Breast Cancer Susceptibility Gene: Results from a Consortium Study among Asians

Author

Ma, Xiangyu, primary, Beeghly-Fadiel, Alicia, primary, Lu, Wei, primary, Shi, Jiajun, primary, Xiang, Yong-Bing, primary, Cai, Qiuyin, primary, Shen, Hongbing, primary, Shen, Chen-Yang, primary, Ren, Zefang, primary, Matsuo, Keitaro, primary, Khoo, Ui Soon, primary, Iwasaki, Motoki, primary, Long, Jirong, primary, Zhang, Ben, primary, Ji, Bu-Tian, primary, Zheng, Ying, primary, Wang, Wenjing, primary, Hu, Zhibin, primary, Liu, Yao, primary, Wu, Pei-Ei, primary, Shieh, Ya-Lan, primary, Wang, Shenming, primary, Xie, Xiaoming, primary, Ito, Hidemi, primary, Kasuga, Yoshio, primary, Chan, Kelvin Y.K., primary, Iwata, Hiroji, primary, Tsugane, Shoichiro, primary, Gao, Yu-Tang, primary, Shu, Xiao Ou, primary, Moses, Harold L., primary, and Zheng, Wei, primary

Published
2023
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46. Supplementary Figure 2 from Metabolomics in Epidemiology: Sources of Variability in Metabolite Measurements and Implications

Author

Sampson, Joshua N., primary, Boca, Simina M., primary, Shu, Xiao Ou, primary, Stolzenberg-Solomon, Rachael Z., primary, Matthews, Charles E., primary, Hsing, Ann W., primary, Tan, Yu Ting, primary, Ji, Bu-Tian, primary, Chow, Wong-Ho, primary, Cai, Qiuyin, primary, Liu, Da Ke, primary, Yang, Gong, primary, Xiang, Yong Bing, primary, Zheng, Wei, primary, Sinha, Rashmi, primary, Cross, Amanda J., primary, and Moore, Steven C., primary

Published
2023
Full Text
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47. Supplementary Table 1 from Metabolomics in Epidemiology: Sources of Variability in Metabolite Measurements and Implications

Author

Sampson, Joshua N., primary, Boca, Simina M., primary, Shu, Xiao Ou, primary, Stolzenberg-Solomon, Rachael Z., primary, Matthews, Charles E., primary, Hsing, Ann W., primary, Tan, Yu Ting, primary, Ji, Bu-Tian, primary, Chow, Wong-Ho, primary, Cai, Qiuyin, primary, Liu, Da Ke, primary, Yang, Gong, primary, Xiang, Yong Bing, primary, Zheng, Wei, primary, Sinha, Rashmi, primary, Cross, Amanda J., primary, and Moore, Steven C., primary

Published
2023
Full Text
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48. Supplementary Tables 1 - 3 from Pathway Analyses Identify TGFBR2 as Potential Breast Cancer Susceptibility Gene: Results from a Consortium Study among Asians

Author

Ma, Xiangyu, primary, Beeghly-Fadiel, Alicia, primary, Lu, Wei, primary, Shi, Jiajun, primary, Xiang, Yong-Bing, primary, Cai, Qiuyin, primary, Shen, Hongbing, primary, Shen, Chen-Yang, primary, Ren, Zefang, primary, Matsuo, Keitaro, primary, Khoo, Ui Soon, primary, Iwasaki, Motoki, primary, Long, Jirong, primary, Zhang, Ben, primary, Ji, Bu-Tian, primary, Zheng, Ying, primary, Wang, Wenjing, primary, Hu, Zhibin, primary, Liu, Yao, primary, Wu, Pei-Ei, primary, Shieh, Ya-Lan, primary, Wang, Shenming, primary, Xie, Xiaoming, primary, Ito, Hidemi, primary, Kasuga, Yoshio, primary, Chan, Kelvin Y.K., primary, Iwata, Hiroji, primary, Tsugane, Shoichiro, primary, Gao, Yu-Tang, primary, Shu, Xiao Ou, primary, Moses, Harold L., primary, and Zheng, Wei, primary

Published
2023
Full Text
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49. Supplementary Figure 1 from Genome-Wide Association Study Identifies a Possible Susceptibility Locus for Endometrial Cancer

Author

Long, Jirong, primary, Zheng, Wei, primary, Xiang, Yong-Bing, primary, Lose, Felicity, primary, Thompson, Deborah, primary, Tomlinson, Ian, primary, Yu, Herbert, primary, Wentzensen, Nicolas, primary, Lambrechts, Diether, primary, Dörk, Thilo, primary, Dubrowinskaja, Natalia, primary, Goodman, Marc T., primary, Salvesen, Helga B., primary, Fasching, Peter A., primary, Scott, Rodney J., primary, Delahanty, Ryan, primary, Zheng, Ying, primary, O'Mara, Tracy, primary, Healey, Catherine S., primary, Hodgson, Shirley, primary, Risch, Harvey, primary, Yang, Hannah P., primary, Amant, Frederic, primary, Turmanov, Nurzhan, primary, Schwake, Anita, primary, Lurie, Galina, primary, Trovik, Jone, primary, Beckmann, Matthias W., primary, Ashton, Katie, primary, Ji, Bu-Tian, primary, Bao, Ping-Ping, primary, Howarth, Kimberly, primary, Lu, Lingeng, primary, Lissowska, Jolanta, primary, Coenegrachts, Lieve, primary, Kaidarova, Dilyara, primary, Dürst, Matthias, primary, Thompson, Pamela J., primary, Krakstad, Camilla, primary, Ekici, Arif B., primary, Otton, Geoffrey, primary, Shi, Jiajun, primary, Zhang, Ben, primary, Gorman, Maggie, primary, Brinton, Louise, primary, Coosemans, An, primary, Matsuno, Rayna K., primary, Halle, Mari K., primary, Hein, Alexander, primary, Proietto, Anthony, primary, Cai, Hui, primary, Lu, Wei, primary, Dunning, Alison, primary, Easton, Douglas, primary, Gao, Yu-Tang, primary, Cai, Qiuyin, primary, Spurdle, Amanda B., primary, and Shu, Xiao-Ou, primary

Published
2023
Full Text
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50. Supplementary Figure 2 from Genome-Wide Association Study Identifies a Possible Susceptibility Locus for Endometrial Cancer

Author

Long, Jirong, primary, Zheng, Wei, primary, Xiang, Yong-Bing, primary, Lose, Felicity, primary, Thompson, Deborah, primary, Tomlinson, Ian, primary, Yu, Herbert, primary, Wentzensen, Nicolas, primary, Lambrechts, Diether, primary, Dörk, Thilo, primary, Dubrowinskaja, Natalia, primary, Goodman, Marc T., primary, Salvesen, Helga B., primary, Fasching, Peter A., primary, Scott, Rodney J., primary, Delahanty, Ryan, primary, Zheng, Ying, primary, O'Mara, Tracy, primary, Healey, Catherine S., primary, Hodgson, Shirley, primary, Risch, Harvey, primary, Yang, Hannah P., primary, Amant, Frederic, primary, Turmanov, Nurzhan, primary, Schwake, Anita, primary, Lurie, Galina, primary, Trovik, Jone, primary, Beckmann, Matthias W., primary, Ashton, Katie, primary, Ji, Bu-Tian, primary, Bao, Ping-Ping, primary, Howarth, Kimberly, primary, Lu, Lingeng, primary, Lissowska, Jolanta, primary, Coenegrachts, Lieve, primary, Kaidarova, Dilyara, primary, Dürst, Matthias, primary, Thompson, Pamela J., primary, Krakstad, Camilla, primary, Ekici, Arif B., primary, Otton, Geoffrey, primary, Shi, Jiajun, primary, Zhang, Ben, primary, Gorman, Maggie, primary, Brinton, Louise, primary, Coosemans, An, primary, Matsuno, Rayna K., primary, Halle, Mari K., primary, Hein, Alexander, primary, Proietto, Anthony, primary, Cai, Hui, primary, Lu, Wei, primary, Dunning, Alison, primary, Easton, Douglas, primary, Gao, Yu-Tang, primary, Cai, Qiuyin, primary, Spurdle, Amanda B., primary, and Shu, Xiao-Ou, primary

Published
2023
Full Text
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