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5 results on '"Jhun, Mina-A"'

1. CD36 regulates factor VIII secretion from liver endothelial cells

Author

Dehghan, Abbas, Gill, Dipender, Elliot, Paul, Pankratz, Nathan, Tang, Weihong, Wei, Peng, deVries, Paul, Brown, Michael, Bressler, Jan, Hahn, Julie, Friedman, Rachel K., Heath, Adam, Morrison, Alanna, Strachan, David, Reiner, Alex P., Conomos, Matt, Psaty, Bruce M., Brody, Jen, Bis, Joshua C., Wiggins, Kerri L., Smith, Nicholas L., Hayward, Caroline, Richmond, Anne, O’Donnell, Chris, Huffman, Jenny, Chen, Ming-Huei, Yang, Qiong, Thibord, Florian, Liu, Melissa, Johnson, Andrew, Desch, Karl, Sabater-Lleal, Maria, Temprano, Gerard, Díez, Laia, Yanek, Lisa, Peyser, Patricia, Jhun, Mina, Wild, Philipp, Reiner, Alex, Raffield, Laura, Taylor, Herman, Nicholas, Jayna, Youkhana, Kim, Peters, Annette, Mueller, Martina, Ward-Caviness, Cavin, Koenig, Wolfgang, Cox, Simon, Davies, Gail, Marioni, Riccardo, Kleber, Marcus, Tregouet, David, Morange, Pierre, Rosendaal, Frits R., van Hylckama Vlieg, Astrid, Rotter, Jerry, Yao, Jie, Guo, Xiuqing, Damrauer, Scott, Li, Ruifang, Mook, Dennis, Campbell, Harry, van der Harst, Pim, Asselbergs, Folkert, Jukema, Wouter, Trompet, Stella, Kavousi, Maryam, Leebeek, Frank, de Maat, Moniek, Felix, Stephan, Voelker, Uwe, Homuth, Georg, Mangino, Massimo, Chasman, Daniel, Reventun, Paula, Toledano-Sanz, Pablo, Alcharani, Nunzio, Viskadourou, Maria, Morrison, Alanna C., Wolberg, Alisa S., de Vries, Paul S., Osburn, William O., Arvanitis, Marios, and Lowenstein, Charles J.

Published
2024
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2. CD36 regulates factor VIII secretion from liver endothelial cells

Author

Reventun, Paula, Toledano-Sanz, Pablo, Alcharani, Nunzio, Viskadourou, Maria, Morrison, Alanna C., Sabater-Lleal, Maria, Wolberg, Alisa S., de Vries, Paul S., Smith, Nicholas L., Osburn, William O., Arvanitis, Marios, Lowenstein, Charles J., Dehghan, Abbas, Gill, Dipender, Elliot, Paul, Pankratz, Nathan, Tang, Weihong, Wei, Peng, deVries, Paul, Brown, Michael, Bressler, Jan, Hahn, Julie, Friedman, Rachel K., Heath, Adam, Morrison, Alanna, Strachan, David, Reiner, Alex P., Conomos, Matt, Psaty, Bruce M., Brody, Jen, Bis, Joshua C., Wiggins, Kerri L., Smith, Nicholas L., Hayward, Caroline, Richmond, Anne, O’Donnell, Chris, Huffman, Jenny, Chen, Ming-Huei, Yang, Qiong, Thibord, Florian, Liu, Melissa, Johnson, Andrew, Desch, Karl, Sabater-Lleal, Maria, Temprano, Gerard, Díez, Laia, Yanek, Lisa, Peyser, Patricia, Jhun, Mina, Wild, Philipp, Reiner, Alex, Raffield, Laura, Taylor, Herman, Nicholas, Jayna, Youkhana, Kim, Peters, Annette, Mueller, Martina, Ward-Caviness, Cavin, Koenig, Wolfgang, Cox, Simon, Davies, Gail, Marioni, Riccardo, Kleber, Marcus, Tregouet, David, Morange, Pierre, Rosendaal, Frits R., van Hylckama Vlieg, Astrid, Rotter, Jerry, Yao, Jie, Guo, Xiuqing, O’Donnell, Chris, Damrauer, Scott, Li, Ruifang, Mook, Dennis, Rosendaal, Frits R., Campbell, Harry, van der Harst, Pim, Asselbergs, Folkert, Sabater-Lleal, Maria, Jukema, Wouter, Trompet, Stella, Sabater-Lleal, Maria, Kavousi, Maryam, Leebeek, Frank, de Maat, Moniek, Felix, Stephan, Voelker, Uwe, Homuth, Georg, Mangino, Massimo, Reiner, Alex P., and Chasman, Daniel

Published
2024
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3. A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids

Author

Jhun, Mina-A, Mendelson, Michael, Wilson, Rory, Gondalia, Rahul, Joehanes, Roby, Salfati, Elias, Zhao, Xiaoping, Braun, Kim Valeska Emilie, Do, Anh Nguyet, Hedman, Åsa K, Zhang, Tao, Carnero-Montoro, Elena, Shen, Jincheng, Bartz, Traci M., Brody, Jennifer A., Montasser, May E., O'Connell, Jeff R., Yao, Chen, Xia, Rui, Boerwinkle, Eric, Grove, Megan, Guan, Weihua, Liliane, Pfeiffer, Singmann, Paula, Mueller-Nurasyid, Martina, Meitinger, Thomas, Gieger, Christian, Peters, Annette, Zhao, Wei, Ware, Erin B., Smith, Jennifer A., Dhana, Klodian, van Meurs, Joyce, Uitterlinden, Andre, Ikram, Mohammad Arfan, Ghanbari, Mohsen, Zhi, Deugi, Gustafsson, Stefan, Lind, Lars, Li, Shengxu, Sun, Dianjianyi, Spector, Tim D., Chen, Yii-der Ida, Damcott, Coleen, Shuldiner, Alan R., Absher, Devin M., Horvath, Steve, Tsao, Philip S., Kardia, Sharon, Psaty, Bruce M., Sotoodehnia, Nona, Bell, Jordana T., Ingelsson, Erik, Chen, Wei, Dehghan, Abbas, Arnett, Donna K., Waldenberger, Melanie, Hou, Lifang, Whitsel, Eric A., Baccarelli, Andrea, Levy, Daniel, Fornage, Myriam, Irvin, Marguerite R., Assimes, Themistocles L., Jhun, Mina-A, Mendelson, Michael, Wilson, Rory, Gondalia, Rahul, Joehanes, Roby, Salfati, Elias, Zhao, Xiaoping, Braun, Kim Valeska Emilie, Do, Anh Nguyet, Hedman, Åsa K, Zhang, Tao, Carnero-Montoro, Elena, Shen, Jincheng, Bartz, Traci M., Brody, Jennifer A., Montasser, May E., O'Connell, Jeff R., Yao, Chen, Xia, Rui, Boerwinkle, Eric, Grove, Megan, Guan, Weihua, Liliane, Pfeiffer, Singmann, Paula, Mueller-Nurasyid, Martina, Meitinger, Thomas, Gieger, Christian, Peters, Annette, Zhao, Wei, Ware, Erin B., Smith, Jennifer A., Dhana, Klodian, van Meurs, Joyce, Uitterlinden, Andre, Ikram, Mohammad Arfan, Ghanbari, Mohsen, Zhi, Deugi, Gustafsson, Stefan, Lind, Lars, Li, Shengxu, Sun, Dianjianyi, Spector, Tim D., Chen, Yii-der Ida, Damcott, Coleen, Shuldiner, Alan R., Absher, Devin M., Horvath, Steve, Tsao, Philip S., Kardia, Sharon, Psaty, Bruce M., Sotoodehnia, Nona, Bell, Jordana T., Ingelsson, Erik, Chen, Wei, Dehghan, Abbas, Arnett, Donna K., Waldenberger, Melanie, Hou, Lifang, Whitsel, Eric A., Baccarelli, Andrea, Levy, Daniel, Fornage, Myriam, Irvin, Marguerite R., and Assimes, Themistocles L.

Abstract

Here we examine the association between DNA methylation in circulating leukocytes and blood lipids in a multi-ethnic sample of 16,265 subjects. We identify 148, 35, and 4 novel associations among Europeans, African Americans, and Hispanics, respectively, and an additional 186 novel associations through a trans-ethnic meta-analysis. We observe a high concordance in the direction of effects across racial/ethnic groups, a high correlation of effect sizes between high-density lipoprotein and triglycerides, a modest overlap of associations with epigenome-wide association studies of other cardio-metabolic traits, and a largely non-overlap with lipid loci identified to date through genome-wide association studies. Thirty CpGs reached significance in at least 2 racial/ethnic groups including 7 that showed association with the expression of an annotated gene. CpGs annotated to CPT1A showed evidence of being influenced by triglycerides levels. DNA methylation levels of circulating leukocytes show robust and consistent association with blood lipid levels across multiple racial/ethnic groups. Abnormal blood lipid levels are important risk factors for cardiovascular and other various diseases. Here the authors conduct a large-scale multi-ethnic epigenome-wide association study combined with epigenetic (cis-QTL and eQTM) data, and identify CpG-lipid traits associations that are specific to or common across racial/ethnic groups.

Published
2021
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