15 results on '"Jhong-You Li"'
Search Results
2. Percutaneous screw stabilization facilitates rapid pain relief and functional recovery for fragility fractures of pelvis with lateral compression type fracture: a retrospective observational study
- Author
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Jhong-You Li, Chung-Hwan Chen, Sung-Yen Lin, Yen-Zung Wu, and Je-Ken Chang
- Subjects
Diseases of the musculoskeletal system ,RC925-935 - Published
- 2023
- Full Text
- View/download PDF
3. A multimodal approach to ameliorate acute phase reaction induced by zoledronic acid
- Author
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Chung-Hwan Chen, Sung-Yen Lin, Tien-Ching Lee, Cheng-Jung Ho, and Jhong-You Li
- Subjects
Diseases of the musculoskeletal system ,RC925-935 - Published
- 2023
- Full Text
- View/download PDF
4. The Role of Autophagy in Osteoarthritic Cartilage
- Author
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Wei-Chun Kao, Jian-Chih Chen, Ping-Cheng Liu, Cheng-Chang Lu, Sung-Yen Lin, Shu-Chun Chuang, Shun-Cheng Wu, Ling-hua Chang, Mon-Juan Lee, Chung-Da Yang, Tien-Ching Lee, Ying-Chun Wang, Jhong-You Li, Chun-Wang Wei, and Chung-Hwan Chen
- Subjects
AMP-activated protein kinase (AMPK) ,Autophagy ,circular RNAs ,microRNAs ,long non-coding RNAs ,non-coding RNAs ,Microbiology ,QR1-502 - Abstract
Osteoarthritis (OA) is one of the most common diseases leading to physical disability, with age being the main risk factor, and degeneration of articular cartilage is the main focus for the pathogenesis of OA. Autophagy is a crucial intracellular homeostasis system recycling flawed macromolecules and cellular organelles to sustain the metabolism of cells. Growing evidences have revealed that autophagy is chondroprotective by regulating apoptosis and repairing the function of damaged chondrocytes. Then, OA is related to autophagy depending on different stages and models. In this review, we discuss the character of autophagy in OA and the process of the autophagy pathway, which can be modulated by some drugs, key molecules and non-coding RNAs (microRNAs, long non-coding RNAs and circular RNAs). More in-depth investigations of autophagy are needed to find therapeutic targets or diagnostic biomarkers through in vitro and in vivo situations, making autophagy a more effective way for OA treatment in the future. The aim of this review is to introduce the concept of autophagy and make readers realize its impact on OA. The database we searched in is PubMed and we used the keywords listed below to find appropriate article resources.
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- 2022
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- View/download PDF
5. The Role of Mitochondrial Metabolism, AMPK-SIRT Mediated Pathway, LncRNA and MicroRNA in Osteoarthritis
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Hao-Yu Liu, Chi-Fen Chang, Cheng-Chang Lu, Shun-Cheng Wu, Bin Huang, Tsung-Lin Cheng, Sung-Yen Lin, Cheng-Jung Ho, Mon-Juan Lee, Chung-Da Yang, Ying-Chun Wang, Jhong-You Li, Ping-Cheng Liu, Chun-Wang Wei, Lin Kang, and Chung-Hwan Chen
- Subjects
osteoarthritis ,mitochondria ,AMP-activated protein kinase (AMPK) ,sirtuins (SIRT) ,long non-coding RNA (lncRNA) ,microRNA (miRNA) ,Biology (General) ,QH301-705.5 - Abstract
Osteoarthritis (OA) is the most common joint disease characterized by degeneration of articular cartilage and causes severe joint pain, physical disability, and impaired quality of life. Recently, it was found that mitochondria not only act as a powerhouse of cells that provide energy for cellular metabolism, but are also involved in crucial pathways responsible for maintaining chondrocyte physiology. Therefore, a growing amount of evidence emphasizes that impairment of mitochondrial function is associated with OA pathogenesis; however, the exact mechanism is not well known. Moreover, the AMP-activated protein kinase (AMPK)–Sirtuin (SIRT) signaling pathway, long non-coding RNA (lncRNA), and microRNA (miRNA) are important for regulating the physiological and pathological processes of chondrocytes, indicating that these may be targets for OA treatment. In this review, we first focus on the importance of mitochondria metabolic dysregulation related to OA. Then, we show recent evidence on the AMPK-SIRT mediated pathway associated with OA pathogenesis and potential treatment options. Finally, we discuss current research into the effects of lncRNA and miRNA on OA progression or inhibition.
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- 2022
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- View/download PDF
6. Hyperuricemia and Its Association with Osteoporosis in a Large Asian Cohort
- Author
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Jhong-You Li, Jia-In Lee, Cheng-Chang Lu, Yu-De Su, Chao-Tse Chiu, Szu-Chia Chen, Jiun-Hung Geng, and Chung-Hwan Chen
- Subjects
epidemiologic study ,osteoporosis ,hyperuricemia ,risk factors ,Nutrition. Foods and food supply ,TX341-641 - Abstract
In this paper, we aimed to examine the protective role of hyperuricemia in the prevalence of osteoporosis in a large Asian cohort. A total of 119,037 participants from 29 recruitment centers in Taiwan were enrolled onto our study. Participants with serum uric acid greater than 7.0 mg/dL in men and 6.0 mg/dL in women were classified as the hyperuricemia group whereas the others were the control group. The mean age of all participants was 50; there were 23,114 subjects (19%) with hyperuricemia. Osteoporosis was observed in 8243 (9%) and 1871 (8%) participants in the control and hyperuricemia groups, respectively. After adjusting for confounders, a lower risk of osteoporosis was found in the hyperuricemia group compared with the control group (odds ratio, 0.916; 95% confidence interval, 0.864 to 0.970). A subgroup analysis showed that hyperuricemia was associated with a lower risk of osteoporosis in females, but not in males. Women with serum uric acid greater than 8.0 mg/dL were not associated with a greater risk of osteoporosis. Our study suggests that hyperuricemia decreases the risk of osteoporosis in females, but not in males. The protective role was no longer apparent when the serum uric acid level was greater than 8 mg/dL.
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- 2022
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- View/download PDF
7. Application of microRNA in Human Osteoporosis and Fragility Fracture: A Systemic Review of Literatures
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Yen-Zung Wu, Hsuan-Ti Huang, Tsung-Lin Cheng, Yen-Mou Lu, Sung-Yen Lin, Cheng-Jung Ho, Tien-Ching Lee, Chia-Hao Hsu, Peng-Ju Huang, Han Hsiang Huang, Jhong-You Li, Yu-De Su, Shih-Chieh Chen, Lin Kang, and Chung-Hwan Chen
- Subjects
blood sample ,fragility fracture ,microRNA ,osteoporosis ,osteoblast differentiation ,osteoclast differentiation ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
MicroRNAs (miRNAs) could serve as ideal entry points to the deregulated pathways in osteoporosis due to their relatively simple upstream and downstream relationships with other molecules in the signaling cascades. Our study aimed to give a comprehensive review of the already identified miRNAs in osteoporosis from human blood samples and provide useful information for their clinical application. A systematic literature search for relevant studies was conducted in the Pubmed database from inception to December 2020. We set two essential inclusion criteria: human blood sampling and design of controlled studies. We sorted the results of analysis on human blood samples according to the study settings and compiled the most promising miRNAs with analyzed diagnostic values. Furthermore, in vitro and in vivo evidence for the mechanisms of the identified miRNAs was also illustrated. Based on both diagnostic value and evidence of mechanism from in vitro and in vivo experiments, miR-23b-3p, miR-140-3p, miR-300, miR-155-5p, miR-208a-3p, and miR-637 were preferred candidates in diagnostic panels and as therapeutic agents. Further studies are needed to build sound foundations for the clinical usage of miRNAs in osteoporosis.
- Published
- 2021
- Full Text
- View/download PDF
8. Intra-Articular Injection of (−)-Epigallocatechin 3-Gallate (EGCG) Ameliorates Cartilage Degeneration in Guinea Pigs with Spontaneous Osteoarthritis
- Author
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Hsuan-Ti Huang, Tsung-Lin Cheng, Chung-Da Yang, Chi-Fen Chang, Cheng-Jung Ho, Shu-Chun Chuang, Jhong-You Li, Shih-Hao Huang, Yi-Shan Lin, Hsin-Yi Shen, Tsung-Han Yu, Lin Kang, Sung-Yen Lin, and Chung-Hwan Chen
- Subjects
(−)-epigallocatechin 3-gallate (EGCG) ,cartilage ,cell senescence ,guinea pigs ,osteoarthritis ,senescence ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Osteoarthritis (OA) is the most prevalent joint disease that causes an enormous burden of disease worldwide. (−)-Epigallocatechin 3-gallate (EGCG) has been reported to reduce post-traumatic OA progression through its anti-inflammatory property. Aging is the most crucial risk factor of OA, and the majority of OA incidences are related to age and not trauma. In this study, we assess whether EGCG can ameliorate cartilage degradation in primary OA. In an in-vitro study, real-time PCR was performed to assess the expression of genes associated with human articular chondrocyte homeostasis. A spontaneously occurring OA model in guinea pigs was used to investigate the effect of EGCG in vivo. OA severity was evaluated using Safranin O staining and Osteoarthritis Research Society International (OARSI) scores, as well as by immunohistochemical (IHC) analysis to determine the protein level of type II collagen (Col II), matrix metalloproteinase 13 (MMP-13), and p16 ink4a in articular cartilage. In the in-vitro study, EGCG increased the gene expression of aggrecan and Col II and decreased the expression of interleukin-1, cyclooxygenase 2, MMP-13, alkaline phosphatase, Col X, and p16 Ink4a; EGCG treatment also attenuated the degraded cartilage with a lower OARSI score. Meanwhile, IHC results showed that EGCG exerted an anti-OA effect by reducing ECM degradation, cartilage inflammation, and cell senescence with a less-immunostained Col II, MMP-13, and p16 Ink4a. In conclusion, these findings suggest that EGCG may be a potential disease-modifying OA drug for the treatment of primary OA.
- Published
- 2021
- Full Text
- View/download PDF
9. Intra-Articular Injection of (-)-Epigallocatechin 3-Gallate to Attenuate Articular Cartilage Degeneration by Enhancing Autophagy in a Post-Traumatic Osteoarthritis Rat Model
- Author
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Hsuan-Ti Huang, Tsung-Lin Cheng, Cheng-Jung Ho, Han Hsiang Huang, Cheng-Chang Lu, Shu-Chun Chuang, Jhong-You Li, Tien-Ching Lee, Shih-Tse Chen, Yi-Shan Lin, Chih-Yao Lee, Lin Kang, Sung-Yen Lin, and Chung-Hwan Chen
- Subjects
(-)-epigallocatechin 3-gallate (EGCG) ,apoptosis ,autophagy ,cartilage ,mTOR ,post-traumatic osteoarthritis ,Therapeutics. Pharmacology ,RM1-950 - Abstract
(-)-Epigallocatechin 3-gallate (EGCG) is the main active green tea catechin and has a wide variety of benefits for health. Post-traumatic osteoarthritis (PTOA) occurs as a consequence of joint injuries that commonly happen in the young population. In this study, we investigated the effects of EGCG on PTOA prevention by using the anterior cruciate ligament transection (ACLT)–OA model and further investigated the roles of autophagy in OA treatment. Our results showed that intra-articular injection of EGCG significantly improved the functional performances and decreased cartilage degradation. EGCG treatment attenuated the inflammation on synovial tissue and cartilage through less immunostained cyclooxygenase-2 and matrix metalloproteinase-13. We further noted EGCG may modulate the chondrocyte apoptosis by activation of the cytoprotective autophagy through reducing the expression of the mTOR and enhancing the expression of microtubule-associated protein light chain 3, beclin-1, and p62. In conclusion, intra-articular injection of EGCG after ACL injury inhibited the joint inflammation and cartilage degradation, thereby increasing joint function. EGCG treatment also reduced the chondrocyte apoptosis, possibly by activating autophagy. These findings suggested that EGCG may be a potential disease-modifying drug for preventing OA progression.
- Published
- 2020
- Full Text
- View/download PDF
10. Skeletal Muscle Lymphoma Presenting with Chronic Compartment Syndrome of Leg after Trauma
- Author
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Jhong-You Li, Chung-Liang Li, and Chun-Kuan Lu
- Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Compartment syndrome may be acute or chronic based on the clinical course and etiology. Here, we report the first known case to be diagnosed with skeletal muscle-derived B-cell lymphoma presenting with chronic compartment syndrome after trauma. A 62-year-old woman sought medical attention due to a one-month history of painful left lower leg swelling and paresthesia of the medial side of the foot after falling over. The patient underwent fasciotomy and debridement under the preoperative diagnosis of fasciitis and myositis with associated compressive neuropathy. Preoperative laboratory tests were within normal limits. Postoperative pathologic examination and bone marrow aspiration revealed B-cell lymphoma with bone marrow involvement postoperatively. Tumor lysis syndrome took place, presenting with drowsiness, poor appetite, and oliguria, after the operation along with multiple organ failure. Awareness of the differential diagnoses of compartment syndrome in such clinical situation is crucial because it may lead to different examination and treatment plan preoperatively.
- Published
- 2018
- Full Text
- View/download PDF
11. Application of microRNA in Human Osteoporosis and Fragility Fracture: A Systemic Review of Literatures
- Author
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Sung Yen Lin, Peng Ju Huang, Yu De Su, Yen Mou Lu, Tsung Lin Cheng, Tien-Ching Lee, Chung-Hwan Chen, Hsuan-Ti Huang, Lin Kang, Shih Chieh Chen, Jhong You Li, Chia Hao Hsu, Cheng Jung Ho, Han Hsiang Huang, and Yen Zung Wu
- Subjects
Adult ,0301 basic medicine ,QH301-705.5 ,Frail Elderly ,Osteoporosis ,fragility fracture ,Review ,Computational biology ,Controlled studies ,Catalysis ,blood sample ,Inorganic Chemistry ,03 medical and health sciences ,0302 clinical medicine ,microRNA ,Humans ,Medicine ,Physical and Theoretical Chemistry ,Biology (General) ,Wnt Signaling Pathway ,Molecular Biology ,QD1-999 ,Spectroscopy ,Aged ,osteoclast differentiation ,Aged, 80 and over ,Fragility fracture ,Human blood ,business.industry ,Mechanism (biology) ,Organic Chemistry ,Estrogens ,General Medicine ,Middle Aged ,medicine.disease ,osteoporosis ,Computer Science Applications ,MicroRNAs ,Chemistry ,030104 developmental biology ,030220 oncology & carcinogenesis ,osteoblast differentiation ,Female ,business ,Biomarkers ,Osteoporotic Fractures ,Systematic search - Abstract
MicroRNAs (miRNAs) could serve as ideal entry points to the deregulated pathways in osteoporosis due to their relatively simple upstream and downstream relationships with other molecules in the signaling cascades. Our study aimed to give a comprehensive review of the already identified miRNAs in osteoporosis from human blood samples and provide useful information for their clinical application. A systematic literature search for relevant studies was conducted in the Pubmed database from inception to December 2020. We set two essential inclusion criteria: human blood sampling and design of controlled studies. We sorted the results of analysis on human blood samples according to the study settings and compiled the most promising miRNAs with analyzed diagnostic values. Furthermore, in vitro and in vivo evidence for the mechanisms of the identified miRNAs was also illustrated. Based on both diagnostic value and evidence of mechanism from in vitro and in vivo experiments, miR-23b-3p, miR-140-3p, miR-300, miR-155-5p, miR-208a-3p, and miR-637 were preferred candidates in diagnostic panels and as therapeutic agents. Further studies are needed to build sound foundations for the clinical usage of miRNAs in osteoporosis.
- Published
- 2021
12. Hemoglobin A1c Levels Associated with Age and Gender in Taiwanese Adults without Prior Diagnosis with Diabetes
- Author
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Yu-De Su, Chia-Lung Shih, Peng-Ju Huang, Cheng-Chang Lu, Shih-Hao Huang, and Jhong-You Li
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Adult ,Male ,HbA1c ,endocrine system diseases ,Health, Toxicology and Mutagenesis ,Prior diagnosis ,Taiwan ,lcsh:Medicine ,030204 cardiovascular system & hematology ,Positive correlation ,Article ,Age and gender ,03 medical and health sciences ,Hba1c level ,0302 clinical medicine ,Age groups ,Asian People ,Diabetes mellitus ,Diabetes Mellitus ,Medicine ,Humans ,sex ,030212 general & internal medicine ,Aged ,Glycated Hemoglobin ,Hematologic Tests ,business.industry ,lcsh:R ,Public Health, Environmental and Occupational Health ,nutritional and metabolic diseases ,Middle Aged ,medicine.disease ,age ,correlation ,Female ,Hemoglobin ,Analysis of variance ,business ,Demography - Abstract
Several studies have reported that Hemoglobin A1c (HbA1c) levels increase with age for people without diabetes. However, HbA1c levels associated with age and gender have not been well investigated for Taiwanese adults. The objective of this study was to investigate the sex-specific association between HbA1c levels and age for Taiwanese adults without diabetes. The data were collected from the Taiwan Biobank database with inclusive criteria being participants without diabetes. The association between HbA1c values and age was conducted by linear regression analysis, HbA1c values between sexes were compared by two-sample t-test, and HbA1c levels among age groups were compared using one-way ANOVA. The results showed that HbA1c levels were positively correlated with age, and the levels for males were significantly higher than for females among all participants. However, there was no significantly positive correlation between HbA1c levels and age in males for age group of 50–70 years. The levels of males were significantly higher than females for age groups of 30–39 and 40–49 years. There were significant differences in HbA1c levels among age groups for all participants, males, and females except for the two age groups of 50–59 and 60–70 years in males. Age and gender were important factors affecting HbA1c levels. Our results suggested that the HbA1c cut-point levels for the diagnosis of diabetes should vary by age and gender.
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- 2021
- Full Text
- View/download PDF
13. Intra-articular Injection of (-)-Epigallocatechin 3-Gallate (EGCG) Ameliorates Cartilage Degeneration in Guinea Pigs with Spontaneous Osteoarthritis
- Author
-
Jhong You Li, Tsung Lin Cheng, Shih-Hao Huang, Sung Yen Lin, Chung-Hwan Chen, Yi Shan Lin, Shu-Chun Chuang, Chung Da Yang, Lin Kang, Hsin Yi Shen, Hsuan-Ti Huang, Cheng Jung Ho, Chi-Fen Chang, and Tsung Han Yu
- Subjects
0301 basic medicine ,medicine.medical_specialty ,senescence ,Physiology ,Clinical Biochemistry ,Type II collagen ,Osteoarthritis ,Matrix metalloproteinase ,Biochemistry ,Article ,03 medical and health sciences ,0302 clinical medicine ,In vivo ,(−)-epigallocatechin 3-gallate (EGCG) ,Internal medicine ,Medicine ,cartilage ,Molecular Biology ,Aggrecan ,biology ,business.industry ,Cartilage ,lcsh:RM1-950 ,food and beverages ,(-)-epigallocatechin 3-gallate (EGCG) ,Cell Biology ,medicine.disease ,osteoarthritis ,030104 developmental biology ,Endocrinology ,medicine.anatomical_structure ,lcsh:Therapeutics. Pharmacology ,cell senescence ,030220 oncology & carcinogenesis ,biology.protein ,Alkaline phosphatase ,Cyclooxygenase ,business ,guinea pigs - Abstract
Osteoarthritis (OA) is the most prevalent joint disease that causes an enormous burden of disease worldwide. (-)-Epigallocatechin 3-gallate (EGCG) has been reported to reduce post-traumatic OA progression through its anti-inflammatory property. Aging is the most crucial risk factor of OA, and the majority of OA incidences are related to age and not trauma. In this study, we assess whether EGCG can ameliorate cartilage degradation in primary OA. In an in-vitro study, real-time PCR was performed to assess the expression of genes associated with human articular chondrocyte homeostasis. A spontaneously occurring OA model in guinea pigs was used to investigate the effect of EGCG in vivo. OA severity was evaluated using Safranin O staining and Osteoarthritis Research Society International (OARSI) scores, as well as by immunohistochemical (IHC) analysis to determine the protein level of type II collagen (Col II), matrix metalloproteinase 13 (MMP-13), and p16 ink4a in articular cartilage. In the in-vitro study, EGCG increased the gene expression of aggrecan and Col II and decreased the expression of interleukin-1, cyclooxygenase 2, MMP-13, alkaline phosphatase, Col X, and p16 Ink4a, EGCG treatment also attenuated the degraded cartilage with a lower OARSI score. Meanwhile, IHC results showed that EGCG exerted an anti-OA effect by reducing ECM degradation, cartilage inflammation, and cell senescence with a less-immunostained Col II, MMP-13, and p16 Ink4a. In conclusion, these findings suggest that EGCG may be a potential disease-modifying OA drug for the treatment of primary OA.
- Published
- 2021
14. Intra-Articular Injection of (-)-Epigallocatechin 3-Gallate to Attenuate Articular Cartilage Degeneration by Enhancing Autophagy in a Post-Traumatic Osteoarthritis Rat Model
- Author
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Tien-Ching Lee, Chung-Hwan Chen, Shih Tse Chen, Cheng Chang Lu, Tsung Lin Cheng, Sung Yen Lin, Cheng Jung Ho, Jhong You Li, Chih Yao Lee, Shu-Chun Chuang, Yi Shan Lin, Hsuan-Ti Huang, Han Hsiang Huang, and Lin Kang
- Subjects
0301 basic medicine ,autophagy ,Physiology ,Clinical Biochemistry ,Inflammation ,Osteoarthritis ,Pharmacology ,Matrix (biology) ,Biochemistry ,complex mixtures ,Chondrocyte ,Article ,03 medical and health sciences ,0302 clinical medicine ,medicine ,heterocyclic compounds ,post-traumatic osteoarthritis ,cartilage ,Molecular Biology ,PI3K/AKT/mTOR pathway ,business.industry ,Cartilage ,lcsh:RM1-950 ,Autophagy ,apoptosis ,food and beverages ,(-)-epigallocatechin 3-gallate (EGCG) ,Cell Biology ,medicine.disease ,lcsh:Therapeutics. Pharmacology ,030104 developmental biology ,medicine.anatomical_structure ,Apoptosis ,030220 oncology & carcinogenesis ,mTOR ,sense organs ,medicine.symptom ,business - Abstract
(-)-Epigallocatechin 3-gallate (EGCG) is the main active green tea catechin and has a wide variety of benefits for health. Post-traumatic osteoarthritis (PTOA) occurs as a consequence of joint injuries that commonly happen in the young population. In this study, we investigated the effects of EGCG on PTOA prevention by using the anterior cruciate ligament transection (ACLT)&ndash, OA model and further investigated the roles of autophagy in OA treatment. Our results showed that intra-articular injection of EGCG significantly improved the functional performances and decreased cartilage degradation. EGCG treatment attenuated the inflammation on synovial tissue and cartilage through less immunostained cyclooxygenase-2 and matrix metalloproteinase-13. We further noted EGCG may modulate the chondrocyte apoptosis by activation of the cytoprotective autophagy through reducing the expression of the mTOR and enhancing the expression of microtubule-associated protein light chain 3, beclin-1, and p62. In conclusion, intra-articular injection of EGCG after ACL injury inhibited the joint inflammation and cartilage degradation, thereby increasing joint function. EGCG treatment also reduced the chondrocyte apoptosis, possibly by activating autophagy. These findings suggested that EGCG may be a potential disease-modifying drug for preventing OA progression.
- Published
- 2020
- Full Text
- View/download PDF
15. Skeletal Muscle Lymphoma Presenting with Chronic Compartment Syndrome of Leg after Trauma
- Author
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Chung-Liang Li, Chun-Kuan Lu, and Jhong-You Li
- Subjects
030222 orthopedics ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Case Report ,medicine.disease ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,lcsh:RC254-282 ,Surgery ,Lymphoma ,Fasciotomy ,Tumor lysis syndrome ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Oncology ,Oliguria ,030220 oncology & carcinogenesis ,medicine ,Etiology ,Bone marrow ,medicine.symptom ,Fasciitis ,business ,Myositis - Abstract
Compartment syndrome may be acute or chronic based on the clinical course and etiology. Here, we report the first known case to be diagnosed with skeletal muscle-derived B-cell lymphoma presenting with chronic compartment syndrome after trauma. A 62-year-old woman sought medical attention due to a one-month history of painful left lower leg swelling and paresthesia of the medial side of the foot after falling over. The patient underwent fasciotomy and debridement under the preoperative diagnosis of fasciitis and myositis with associated compressive neuropathy. Preoperative laboratory tests were within normal limits. Postoperative pathologic examination and bone marrow aspiration revealed B-cell lymphoma with bone marrow involvement postoperatively. Tumor lysis syndrome took place, presenting with drowsiness, poor appetite, and oliguria, after the operation along with multiple organ failure. Awareness of the differential diagnoses of compartment syndrome in such clinical situation is crucial because it may lead to different examination and treatment plan preoperatively.
- Published
- 2018
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