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The total synthesis of herbarumin III 1 was achieved viaan alkynide ion addition onto a chiral aldehyde and LiAlH4LiI reduction as key steps Scheme2. [ABSTRACT FROM AUTHOR]

The stereoselective total synthesis of an antiproliferative and antifungal αpyrone natural product 6S5,6dihydro62R2hydroxy6phenylhexyl2Hpyran2one is described. The key steps involved are the Prinscyclization, Mitsunobureaction, and ringclosing metathesis reaction. [ABSTRACT FROM AUTHOR]

Phosphomolybdic acid PMA–SiO2was found to be an efficient catalyst for the threecomponent condensation reaction of phthalhydrazide, 1,3diketone, and aldehydes to produce 2Hindazolo1,2bphthalazinetriones in excellent yields. The catalyst can be recovered and reused without significant loss of activity. [ABSTRACT FROM AUTHOR]