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1. Complete Endoscopic Healing Is Associated With Lower Relapse Risk After Anti-TNF Withdrawal in Inflammatory Bowel Disease

Author

Mahmoud, Remi, Savelkoul, Edo H.J., Mares, Wout, Goetgebuer, Rogier, Witteman, Ben J.M., de Koning, Daan B., van Tuyl, Sebastiaan A.C., Minderhoud, Itta, Lutgens, Maurice W.M. D., Akol-Simsek, Dilek, van Schaik, Fiona D.M., Fidder, Herma H., Jansen, Jeroen M., van Boeckel, Petra G.A., Mahmmod, Nofel, Horjus-Talabur Horje, Carmen S., Römkens, Tessa E.H., Colombel, Jean-Frédéric, Hoentjen, Frank, Jharap, Bindia, and Oldenburg, Bas

Published
2023
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2. Superior Effectiveness of Tofacitinib Compared to Vedolizumab in Anti-TNF-experienced Ulcerative Colitis Patients: A Nationwide Dutch Registry Study

Author

Schlotter, Malena, van Workum, Martine, de Jong, Dirk, van Dop, Willemijn, van der Marel, S., El Ghabzouri, Hayat, Talhaoui, Kamila, Oldenburg, Bas, Boontje, Nynke, Fidder, Herma, Hirdes, Meike, Creemers, Rob H., Hoekstra, J., Smid, Jael, Mujagic, Zlatan, François-Verweij, Marthe, Schakel- van den Berge, Toos, Maljaars, Jeroen, Theeuwen, Rosaline, van den Berg, Denise, Gerretsen, Suzanne, Yocarini, Xenia, D’Haens, Geert, Lowenberg, Mark, Grootjans, Joep, Gecse, Krisztina, Bouma, Gerd, Waaijenberg, Petra, Muskens, Bart, Straatmijer, Tessa, Biemans, Vince B.C., Visschedijk, Marijn, Hoentjen, Frank, de Vries, Annemarie, van Bodegraven, Adriaan A., Bodelier, Alexander, de Boer, Nanne K.H., Dijkstra, Gerard, Festen, Noortje, Horjus, Carmen, Jansen, Jeroen M., Jharap, Bindia, Mares, Wout, van Schaik, Fiona D.M., Ponsioen, Cyriel, Romkens, Tessa, Srivastava, Nidhi, van der Voorn, Michael M.P. J.A., West, Rachel, van der Woude, Janneke, Wolvers, Marije D.J., Pierik, Marieke, van der Meulen-de Jong, Andrea E., and Duijvestein, Marjolijn

Published
2023
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4. Treat to target versus standard of care for patients with Crohn's disease treated with ustekinumab (STARDUST): an open-label, multicentre, randomised phase 3b trial

Author

Rocca, Rodolfo, Lopes, Susana, Caprioli, Flavio, Ardizzone, Sandro, Echarri Piudo, Ana, Gionchetti, Paolo, Roblin, Xavier, Seidler, Ursula, Andersson, David, Patel, Kamal, Desreumaux, Pierre, Saibeni, Simone, From, Gustav, Fedurco, Miroslav, Gregus, Milos, Bouhnik, Yoram, Luegering, Andreas, Cosintino, Rocco, Bunganic, Ivan, Ramos, Jaime, Aguas Peris, Mariam, Dewit, Olivier, Principi, Mariabeatrice, Wesley, Emma, Lago, Paula, Nancey, Stephane, Martín Arranz, María Dolores, Hindryckx, Pieter, Orlando, Ambrogio, Geccherle, Andrea, Annunziata, Maria Laura, Hayee, Bu'hussain, Balaz, Jozef, Portela, Francisco, Gilletta, Cyrielle, Kucharzik, Torsten, Mínguez, Miguel, Gisbert, Javier Pérez, Casbas, Ana Gutiérrez, Louis, Edouard, Marino, Marco, Parkes, Gareth, Cummings, Fraser, Jharap, Bindia, Kjeldsen, Jens, Correia, Luís, Ministro, Paula, Ebert, Matthias, Hertervig, Erik, Staessen, Dirk, Dutré, Joris, Colard, Arnaud, Morrison, Graham, Glerup, Henning, Dahlerup, Jens Frederik, Wolfhagen, Frank, Batovsky, Marian, Molnar, Martin, Kadleckova, Barbora, Caldeira, Paulo, Laharie, David, Hebuterne, Xavier, Bonaz, Bruno, Allez, Matthieu, Fischer, Andreas, Hinojosa Del Val, Joaquín Ernesto, Ciria, Miriam Mañosa, Herrera Justiniano, Jose Manuel, Soderman, Charlotte, Chandy, Rajiv, Mowat, Craig, Irving, Peter, Fallingborg, Jan, Matous, Jan, Douda, Tomas, Altwegg, Romain, Benitez, Jose Manuel, Arroyo Villarino, María Teresa, Capón, Jordi Guardiola, Vicenc, Daniel Ginard, Dewint, Pieter, Almer, Sven, Kindt, Sebastien, Danese, Silvio, Vermeire, Severine, D'Haens, Geert, Panés, Julian, Dignass, Axel, Magro, Fernando, Nazar, Maciej, Le Bars, Manuela, Lahaye, Marjolein, Ni, Lioudmila, Bravata, Ivana, Lavie, Frederic, Daperno, Marco, Lukáš, Milan, Armuzzi, Alessandro, Löwenberg, Mark, Gaya, Daniel R, and Peyrin-Biroulet, Laurent

Published
2022
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5. Healthy Cotwins Share Gut Microbiome Signatures With Their Inflammatory Bowel Disease Twins and Unrelated Patients

Author

Oldenburg, Bas, van Wijk, Femke, Brand, Eelco C., Honkoop, Pieter, Jacobs, Rutger J., Ponsioen, Cyriel Y., de Boer, Nanne K.H., Alderlieste, Yasser A., van Herwaarden, Margot A., van Tuyl, Sebastiaan A.C., Lutgens, Maurice W., Janneke van der Woude, C., Mares, Wout G.M., de Koning, Daan B., Bosman, Joukje H., Vecht, Juda, de Schryver, Anneke M.P., van der Meulen-de Jong, Andrea E., Pierik, Marieke J., Boekema, Paul J., Verburg, Robert J., Jharap, Bindia, Willemsen, Gonneke, Boomsma, Dorret I., Jansen, Jeroen M., Stokkers, Pieter C.F., Hoentjen, Frank, Quispel, Rutger, Horjus Talabur Horje, Carmen S., van de Meeberg, Paul C., Mahmmod, Nofel, West, Rachel L., Willems, Marleen, Minderhoud, Itta M., Fidder, Herma H., van Schaik, Fiona D.M., Hirdes, Meike M.C., Boontje, Nynke A., Müskens, Bart L.M., Weersma, Rinse K., Romberg-Camps, Marielle J.L., Klaassen, Marjolein A.Y., Gacesa, Ranko, Vich Vila, Arnau, Ghosh, Hiren, de Zoete, Marcel R., Fu, Jingyuan, Wijmenga, Cisca, and Zhernakova, Alexandra

Published
2021
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7. Multicentre study and systematic review: Allopurinol exposure during pregnancy.

Author

Crouwel, Femke, Simsek, Melek, de Boer, Marjon A., van Asseldonk, Dirk P., Bhalla, Abha, Weusthuis, Angelique L. M., Gilissen, Lennard P. L., Verburg, Robert J., Mares, Wout G. N., Jharap, Bindia, Kuijvenhoven, Johan P., Oldenburg, Bas, Buiter, Hans J. C., Julsgaard, Mette, and de Boer, Nanne K.

Subjects
PREGNANCY, SMALL for gestational age, MULTIPLE pregnancy, ALLOPURINOL, PREGNANCY outcomes, INFLAMMATORY bowel diseases
Abstract

Summary: Background: Data about the safety of allopurinol in pregnant women are sparsely reported. Aims: To investigate the risk of adverse pregnancy outcome and congenital abnormalities after in utero exposure to allopurinol in inflammatory bowel disease (IBD) pregnancies and in general. Methods: We collected safety data of patients with IBD who were treated with allopurinol during pregnancy between January 2013 and March 2022. Additionally, we performed a systematic review about the teratogenic potential of allopurinol. Results: We collected data from 42 allopurinol‐exposed pregnancies, including one twin pregnancy; in all women, allopurinol was combined with a thiopurine. Six pregnancies (14.3%) resulted in miscarriage and one in stillbirth at 32 weeks. A congenital anomaly was observed in one newborn (coarctation of the aorta discovered postpartum). Three pregnancies, including the twin pregnancy, ended in moderate preterm delivery and one in very preterm delivery. Five neonates (15.2%) were small for gestational age. From our literature search, we identified an additional 102 allopurinol‐exposed pregnancies resulting in 129 live births, including 36 infants from our cohort. Ten infants (7.8%) were born with a congenital anomaly. Two (1.6%) had a comparable pattern of multiple anomalies. The systematic review sub‐analysis including only infants born to mothers with IBD (n = 76) revealed that 2.6% of infants had congenital anomalies after in utero exposure to a low dose of allopurinol. Conclusions: Overall, the teratogenicity of allopurinol remains inconclusive. Children conceived by mothers treated for IBD with allopurinol/thiopurine co‐therapy do not seem to have an increased risk of congenital anomalies. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Multicentre study and systematic review: Allopurinol exposure during pregnancy

Author

MS MDL 1, Infection & Immunity, Crouwel, Femke, Simsek, Melek, de Boer, Marjon A, van Asseldonk, Dirk P, Bhalla, Abha, Weusthuis, Angelique L M, Gilissen, Lennard P L, Verburg, Robert J, Mares, Wout G N, Jharap, Bindia, Kuijvenhoven, Johan P, Oldenburg, Bas, Buiter, Hans J C, Julsgaard, Mette, de Boer, Nanne K, MS MDL 1, Infection & Immunity, Crouwel, Femke, Simsek, Melek, de Boer, Marjon A, van Asseldonk, Dirk P, Bhalla, Abha, Weusthuis, Angelique L M, Gilissen, Lennard P L, Verburg, Robert J, Mares, Wout G N, Jharap, Bindia, Kuijvenhoven, Johan P, Oldenburg, Bas, Buiter, Hans J C, Julsgaard, Mette, and de Boer, Nanne K

Published
2024

10. Prophylactic Medication for the Prevention of Endoscopic Recurrence in Crohn's Disease: A Prospective Study Based on Clinical Risk Stratification

Author

MS MDL 1, Arkenbosch, Jeanine H.C., Beelen, Evelien M.J., Dijkstra, Gerard, Romberg-Camps, Mariëlle, Duijvestein, Marjolijn, Hoentjen, Frank, Van Der Marel, Sander, Maljaars, P. W.Jeroen, Jansen, Sita, De Boer, Nanne K.H., West, Rachel L., Horjus, Carmen S., Stassen, Laurents P.S., Van Schaik, Fiona D.M., Van Ruler, Oddeke, Jharap, Bindia J.H., Visschedijk, Marijn, Janssen, Alfred, Erler, Nicole S., Doukas, Michail, Ooms, Ariadne H.A.G., Kats-Ugurlu, Gursah, Van Der Woude, Christien Janneke, De Vries, Annemarie C., MS MDL 1, Arkenbosch, Jeanine H.C., Beelen, Evelien M.J., Dijkstra, Gerard, Romberg-Camps, Mariëlle, Duijvestein, Marjolijn, Hoentjen, Frank, Van Der Marel, Sander, Maljaars, P. W.Jeroen, Jansen, Sita, De Boer, Nanne K.H., West, Rachel L., Horjus, Carmen S., Stassen, Laurents P.S., Van Schaik, Fiona D.M., Van Ruler, Oddeke, Jharap, Bindia J.H., Visschedijk, Marijn, Janssen, Alfred, Erler, Nicole S., Doukas, Michail, Ooms, Ariadne H.A.G., Kats-Ugurlu, Gursah, Van Der Woude, Christien Janneke, and De Vries, Annemarie C.

Published
2023

11. Prophylactic medication for the prevention of endoscopic recurrence in Crohn's disease:a prospective study based on clinical risk stratification

Author

Arkenbosch, Jeanine H C, Beelen, Evelien M J, Dijkstra, Gerard, Romberg-Camps, Mariëlle, Duijvestein, Marjolijn, Hoentjen, Frank, van der Marel, Sander, Maljaars, P W Jeroen, Jansen, Sita, de Boer, Nanne K H, West, Rachel L, Horjus, Carmen S, Stassen, Laurents P S, van Schaik, Fiona D M, van Ruler, Oddeke, Jharap, Bindia J H, Visschedijk, Marijn, Janssen, Alfred, Erler, Nicole S, Doukas, Michail, Ooms, Ariadne H A G, Kats-Ugurlu, Gursah, van der Woude, C Janneke, de Vries, Annemarie C, Arkenbosch, Jeanine H C, Beelen, Evelien M J, Dijkstra, Gerard, Romberg-Camps, Mariëlle, Duijvestein, Marjolijn, Hoentjen, Frank, van der Marel, Sander, Maljaars, P W Jeroen, Jansen, Sita, de Boer, Nanne K H, West, Rachel L, Horjus, Carmen S, Stassen, Laurents P S, van Schaik, Fiona D M, van Ruler, Oddeke, Jharap, Bindia J H, Visschedijk, Marijn, Janssen, Alfred, Erler, Nicole S, Doukas, Michail, Ooms, Ariadne H A G, Kats-Ugurlu, Gursah, van der Woude, C Janneke, and de Vries, Annemarie C

Abstract

BACKGROUND: To prevent recurrence after ileocolonic resection [ICR] in Crohn's disease [CD], postoperative prophylaxis based on risk stratification is recommended in international guidelines. This study aimed to evaluate postoperative CD recurrence after implementation of a clinical management algorithm and to determine the predictive value of clinical and histological risk factors [RFs]. METHODS: In this multicentre, prospective cohort study, CD patients [≥16 years] scheduled for ICR were included. The algorithm advised no postoperative medication for low-risk patients, and treatment with prophylaxis [immunosuppressant/biological] for high-risk patients [≥1 RF: active smoking, penetrating disease, prior ICR]. Clinical and histological RFs [active inflammation, granulomas, plexitis in resection margins] for endoscopic recurrence [Rutgeerts' score ≥i2b at 6 months] were assessed using logistic regression and ROC curves based on predicted probabilities. RESULTS: In total, 213 CD patients after ICR were included [age 34.5 years; 65% women] (93 [44%] low-risk; 120 [56%] high-risk: 45 [38%] smoking; 51 [43%] penetrating disease; 51 [43%] prior ICR). Adherence to the algorithm was 82% in low-risk [no prophylaxis] and 51% in high-risk patients [prophylaxis]. Endoscopic recurrence was higher in patients treated without prophylaxis than with prophylaxis in both low [45% vs 16%, p = 0.012] and high-risk patients [49% vs 26%, p = 0.019]. Clinical risk stratification including the prescription of prophylaxis corresponded to an area under the curve [AUC] of 0.70 (95% confidence interval [CI] 0.61-0.79). Clinical RFs combined with histological RFs increased the AUC to 0.73 [95% CI 0.64-0.81]. CONCLUSION: Adherence to this management algorithm is 65%. Prophylactic medication after ICR prevents endoscopic recurrence in low- and high-risk patients. Clinical risk stratification has an acceptable predictive value, but further refinement is needed.

Published
2023

12. Thioguanine is Effective as Maintenance Therapy for Inflammatory Bowel Disease: A Prospective Multicentre Registry Study

Author

MS MDL 1, Cancer, Infection & Immunity, Simsek, Melek, Schepers, Femke, Kaplan, Sigal, Van Asseldonk, Dirk, Van Boeckel, Petra, Boekema, Paul, Dijkstra, Gerard, Fidder, Herma, Gisbertz, Ingrid, Hoentjen, Frank, Jharap, Bindia, Kubben, Frank, De Leest, Marleen, Meijssen, Maarten, Petrak, Ana, Van De Poel, Else, Russel, Maurice, Van Bodegraven, Adriaan A., Mulder, Chris J.J., De Boer, Nanne, MS MDL 1, Cancer, Infection & Immunity, Simsek, Melek, Schepers, Femke, Kaplan, Sigal, Van Asseldonk, Dirk, Van Boeckel, Petra, Boekema, Paul, Dijkstra, Gerard, Fidder, Herma, Gisbertz, Ingrid, Hoentjen, Frank, Jharap, Bindia, Kubben, Frank, De Leest, Marleen, Meijssen, Maarten, Petrak, Ana, Van De Poel, Else, Russel, Maurice, Van Bodegraven, Adriaan A., Mulder, Chris J.J., and De Boer, Nanne

Published
2023

13. Thioguanine is effective as maintenance therapy for inflammatory bowel disease: a prospective multicentre registry study

Author

Simsek, Melek, primary, Schepers, Femke, additional, Kaplan, Sigal, additional, van Asseldonk, Dirk, additional, van Boeckel, Petra, additional, Boekema, Paul, additional, Dijkstra, Gerard, additional, Fidder, Herma, additional, Gisbertz, Ingrid, additional, Hoentjen, Frank, additional, Jharap, Bindia, additional, Kubben, Frank, additional, de Leest, Marleen, additional, Meijssen, Maarten, additional, Petrak, Ana, additional, van de Poel, Else, additional, Russel, Maurice, additional, van Bodegraven, Adriaan A, additional, Mulder, Chris J J, additional, and de Boer, Nanne, additional

Published
2023
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14. Superior Effectiveness of Tofacitinib Compared to Vedolizumab in Anti-TNF-experienced Ulcerative Colitis Patients: A Nationwide Dutch Registry Study

Author

Straatmijer, Tessa, primary, Biemans, Vince B.C., additional, Visschedijk, Marijn, additional, Hoentjen, Frank, additional, de Vries, Annemarie, additional, van Bodegraven, Adriaan A., additional, Bodelier, Alexander, additional, de Boer, Nanne K.H., additional, Dijkstra, Gerard, additional, Festen, Noortje, additional, Horjus, Carmen, additional, Jansen, Jeroen M., additional, Jharap, Bindia, additional, Mares, Wout, additional, van Schaik, Fiona D.M., additional, Ponsioen, Cyriel, additional, Romkens, Tessa, additional, Srivastava, Nidhi, additional, van der Voorn, Michael M.P. J.A., additional, West, Rachel, additional, van der Woude, Janneke, additional, Wolvers, Marije D.J., additional, Pierik, Marieke, additional, van der Meulen-de Jong, Andrea E., additional, Duijvestein, Marjolijn, additional, Schlotter, Malena, additional, van Workum, Martine, additional, de Jong, Dirk, additional, van Dop, Willemijn, additional, van der Marel, S., additional, El Ghabzouri, Hayat, additional, Talhaoui, Kamila, additional, Oldenburg, Bas, additional, Boontje, Nynke, additional, Fidder, Herma, additional, Hirdes, Meike, additional, Creemers, Rob H., additional, Hoekstra, J., additional, Smid, Jael, additional, Mujagic, Zlatan, additional, François-Verweij, Marthe, additional, Schakel- van den Berge, Toos, additional, Maljaars, Jeroen, additional, Theeuwen, Rosaline, additional, van den Berg, Denise, additional, Gerretsen, Suzanne, additional, Yocarini, Xenia, additional, D’Haens, Geert, additional, Lowenberg, Mark, additional, Grootjans, Joep, additional, Gecse, Krisztina, additional, Bouma, Gerd, additional, Waaijenberg, Petra, additional, and Muskens, Bart, additional

Published
2023
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15. Exposure to Thioguanine During 117 Pregnancies in Women With Inflammatory Bowel Disease

Author

Crouwel, Femke, primary, Simsek, Melek, additional, de Boer, Marjon A, additional, Mulder, Chris J J, additional, van Andel, Emma M, additional, Creemers, Rob H, additional, van Asseldonk, Dirk P, additional, van Bodegraven, Ad A, additional, Horjus, Carmen S, additional, Visschedijk, Marijn C, additional, Weusthuis, Angelique L M, additional, Seinen, Margien L, additional, Jharap, Bindia, additional, van Schaik, Fiona D M, additional, Ahmad, Ishfaq, additional, Boekema, Paul J, additional, Tack, Greetje J, additional, Wormmeester, Louktje, additional, Lutgens, Maurice W M D, additional, van Boeckel, Petra G A, additional, Gilissen, Lennard P L, additional, Kerkhof, Marjon, additional, Russel, Maurice G V M, additional, Hoentjen, Frank, additional, Bartelink, Maartje E, additional, Kuijvenhoven, Johan P, additional, Maljaars, Jeroen W J, additional, van Dop, Willemijn A, additional, Wonders, Janneke, additional, van der Voorn, Michael M P J A, additional, Buiter, Hans J C, additional, and de Boer, Nanne K, additional

Published
2022
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16. Anemia and Iron Deficiency in Outpatients with Inflammatory Bowel Disease: Ubiquitous Yet Suboptimally Managed

Author

Loveikyte, Roberta, primary, Boer, Menno, additional, van der Meulen, Catharina N., additional, ter Steege, Rinze W. F., additional, Tack, Greetje, additional, Kuyvenhoven, Johan, additional, Jharap, Bindia, additional, Vu, My K., additional, Vogelaar, Lauran, additional, West, Rachel L., additional, van der Marel, Sander, additional, Römkens, Tessa E. H., additional, Mujagic, Zlatan, additional, Hoentjen, Frank, additional, van Bodegraven, Adriaan A., additional, van Schaik, Fiona D. M., additional, de Vries, Annemarie C., additional, Dijkstra, Gerard, additional, and van der Meulen-de Jong, Andrea E., additional

Published
2022
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17. Reply

Author

Mahmoud, Remi, primary, Savelkoul, Edo H.J., additional, Jharap, Bindia, additional, and Oldenburg, Bas, additional

Published
2022
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18. Sex-Related Differences in Patients With Inflammatory Bowel Disease: Results of 2 Prospective Cohort Studies

Author

Severs, Mirjam, Spekhorst, Lieke M, Mangen, Marie-Josée J, Dijkstra, Gerard, Löwenberg, Mark, Hoentjen, Frank, van der Meulen-de Jong, Andrea E, Pierik, Marieke, Ponsioen, Cyriel Y, Bouma, Gerd, van der Woude, Janneke C, van der Valk, Mirthe E, Romberg-Camps, Marielle J L, Clemens, Cees H M, van de Meeberg, Paul, Mahmmod, Nofel, Jansen, Jeroen, Jharap, Bindia, Weersma, Rinse K, Oldenburg, Bas, Festen, Eleonora A M, and Fidder, Herma H

Published
2018
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19. Prophylactic Medication for the Prevention of Endoscopic Recurrence in Crohn’s Disease: a Prospective Study Based on Clinical Risk Stratification

Author

Arkenbosch, Jeanine H C, primary, Beelen, Evelien M J, additional, Dijkstra, Gerard, additional, Romberg-Camps, Mariëlle, additional, Duijvestein, Marjolijn, additional, Hoentjen, Frank, additional, van der Marel, Sander, additional, Maljaars, P W Jeroen, additional, Jansen, Sita, additional, de Boer, Nanne K H, additional, West, Rachel L, additional, Horjus, Carmen S, additional, Stassen, Laurents P S, additional, van Schaik, Fiona D M, additional, van Ruler, Oddeke, additional, Jharap, Bindia J H, additional, Visschedijk, Marijn, additional, Janssen, Alfred, additional, Erler, Nicole S, additional, Doukas, Michail, additional, Ooms, Ariadne H A G, additional, Kats-Ugurlu, Gursah, additional, van der Woude, C Janneke, additional, and de Vries, Annemarie C, additional

Published
2022
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20. Clinical Predictors of Future Nonadherence in Inflammatory Bowel Disease

Author

Severs, Mirjam, Mangen, Marie-Josée J., Fidder, Herma H., van der Valk, Mirthe E., van der Have, Mike, van Bodegraven, Ad A., Clemens, Cees H. M., Dijkstra, Gerard, Jansen, Jeroen M., de Jong, Dirk J., Mahmmod, Nofel, van de Meeberg, Paul C., van der Meulen-de Jong, Andrea E., Pierik, Marieke, Ponsioen, Cyriel Y., Romberg-Camps, Marielle J. L., Siersema, Peter D., Jharap, Bindia, van der Woude, Janneke C., Zuithoff, Nicolaas P. A., and Oldenburg, Bas

Published
2017
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21. Exposure to Thioguanine During 117 Pregnancies in Women With Inflammatory Bowel Disease.

Author

Crouwel, Femke, Simsek, Melek, Boer, Marjon A de, Mulder, Chris J J, Andel, Emma M van, Creemers, Rob H, Asseldonk, Dirk P van, Bodegraven, Ad A van, Horjus, Carmen S, Visschedijk, Marijn C, Weusthuis, Angelique L M, Seinen, Margien L, Jharap, Bindia, Schaik, Fiona D M van, Ahmad, Ishfaq, Boekema, Paul J, Tack, Greetje J, Wormmeester, Louktje, Lutgens, Maurice W M D, and Boeckel, Petra G A van

Abstract

Background Safety of thioguanine in pregnant patients with inflammatory bowel disease [IBD] is sparsely recorded. This study was aimed to document the safety of thioguanine during pregnancy and birth. Methods In this multicentre case series, IBD patients treated with thioguanine during pregnancy were included. Data regarding disease and medication history, pregnancy course, obstetric complications, and neonatal outcomes were collected. Results Data on 117 thioguanine-exposed pregnancies in 99 women were collected. Most [78%] had Crohn's disease and the mean age at delivery was 31 years. In 18 pregnancies [15%], IBD flared. Obstetric and infectious complications were seen in 15% [ n  = 17] and 7% [ n  = 8] of pregnancies, respectively. Ten pregnancies [8.5%] resulted in a first trimester miscarriage, one in a stillbirth at 22 weeks of gestational age and one in an induced abortion due to trisomy 21. In total, 109 neonates were born from 101 singleton pregnancies and four twin pregnancies. One child was born with a congenital abnormality [cleft palate]. In the singleton pregnancies, 10 children were born prematurely and 10 were born small for gestational age. Screening for myelosuppresion was performed in 16 neonates [14.7%]; two had anaemia in umbilical cord blood. All outcomes were comparable to either the general Dutch population or to data from three Dutch cohort studies on the use of conventional thiopurines in pregnant IBD patients. Conclusion In this large case series, the use of thioguanine during pregnancy is not associated in excess with adverse maternal or neonatal outcomes. [ABSTRACT FROM AUTHOR]

Published
2023
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23. 721: IMMUNOMODULATOR WITHDRAWAL FROM ANTI-TNF THERAPY IS NOT ASSOCIATED WITH LOSS OF RESPONSE IN INFLAMMATORY BOWEL DISEASE

Author

Mahmoud, Remi, primary, Schultheiss, Johannes P., additional, Louwers, Jonas M., additional, Kaaij, Michiel T. van der, additional, Hellemondt, Boris P. van, additional, Mahmmod, Nofel, additional, Boeckel, Petra G. van, additional, Jharap, Bindia, additional, Fidder, Herma H., additional, and Oldenburg, Bas, additional

Published
2022
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24. Tu1498: WITHDRAWAL OF THIOPURINES IN INFLAMMATORY BOWEL DISEASE PATIENTS IN STABLE REMISSION: A PROSPECTIVE, MULTICENTER COHORT STUDY

Author

Savelkoul, Edo, primary, Mahmoud, Remi, additional, Jong, Dirk J. De, additional, Dop, Willemijn A. van, additional, Romkens, Tessa E.H, additional, Nissen, Loes H., additional, Mahmmod, Nofel, additional, Boeckel, Petra G. van, additional, Lutgens, Maurice, additional, Mares, Wout, additional, Epping, Ludger, additional, Minderhoud, Itta M., additional, Jansen, Jeroen M., additional, Gisbertz, Ingrid A., additional, Boekema, Paul, additional, Koning, Daan de, additional, Horje, Carmen S. Horjus Talabur, additional, Jharap, Bindia, additional, Oldenburg, Bas, additional, and Hoentjen, Frank, additional

Published
2022
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25. Mo1539: ANTI-TNF WITHDRAWAL IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE IN ENDOSCOPIC REMISSION: A PROSPECTIVE STUDY

Author

Mahmoud, Remi, primary, Savelkoul, Edo, additional, Mares, Wout, additional, Goetgebuer, Rogier, additional, Witteman, Ben, additional, Koning, Daan de, additional, Minderhoud, Itta M., additional, Tuyl, Sebastiaan van, additional, Boeckel, Petra G. van, additional, Mahmmod, Nofel, additional, Lutgens, Maurice, additional, Horje, Carmen S. Horjus Talabur, additional, Romkens, Tessa E.H, additional, Akol-Simsek, Dilek, additional, Jansen, Jeroen M., additional, Colombel, Jean Frederic, additional, Hoentjen, Frank, additional, Jharap, Bindia, additional, and Oldenburg, Bas, additional

Published
2022
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26. Mo1804 IMAGING-BASED PREOPERATIVE BODY COMPOSITION IS ASSOCIATED WITH THE RISK OF POSTOPERATIVE COMPLICATIONS AND POSTOPERATIVE ENDOSCOPIC RECURRENCE IN PATIENTS WITH CROHN'S DISEASE

Author

Bak, Michiel T., Demers, Karlijn, van Ruler, Oddeke, Pierik, Marie J., van der Bilt, Jarmila D.W., Romberg-Camps, Mariëlle, Dijkstra, Gerard, Duijvestein, Marjolijn, van der Marel, Sander, Maljaars, Jeroen, Buskens, Christianne J., Bakers, Frans C., van Dijk, David P., Brecheisen, Ralph, Bongers, Bart C., van Rossum, Elisabeth F., de Witte, Dennis, Jansen, Sita, Jharap, Bindia, Horje, Carmen S. Horjus Talabur, Van Schaik, Fiona, West, Rachel, De Boer, Nanne, Van Der Woude, Christien Janneke, Stassen, Laurents P., and De Vries, Annemarie C.

Published
2024
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27. Su1839 IDENTIFICATION OF CLINICAL RISK FACTORS FOR POSTOPERATIVE ENDOSCOPIC RECURRENCE IN CROHN'S DISEASE: A PROSPECTIVE, MULTICENTER COHORT STUDY

Author

Bak, Michiel T., Beelen, Evelien, van der Bilt, Jarmila D.W., Romberg-Camps, Mariëlle, Dijkstra, Gerard, Duijvestein, Marjolijn, van der marel, Sander, Stassen, Laurents P., Maljaars, Jeroen, Buskens, Christianne J., Jansen, Sita, Jharap, Bindia, Horje, Carmen S. Horjus Talabur, Van Schaik, Fiona, West, Rachel, de Boer, Nanne, Van Der Woude, Christien Janneke, van Ruler, Oddeke, and De Vries, Annemarie C.

Published
2024
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29. Anemia and Iron Deficiency in Outpatients with Inflammatory Bowel Disease:Ubiquitous Yet Suboptimally Managed

Author

Loveikyte, Roberta, Boer, Menno, van der Meulen, Catharina N., ter Steege, Rinze W.F., Tack, Greetje, Kuyvenhoven, Johan, Jharap, Bindia, Vu, My K., Vogelaar, Lauran, West, Rachel L., van der Marel, Sander, Römkens, Tessa E.H., Mujagic, Zlatan, Hoentjen, Frank, van Bodegraven, Adriaan A., van Schaik, Fiona D.M., de Vries, Annemarie C., van der Meulen-de Jong, Andrea E., Loveikyte, Roberta, Boer, Menno, van der Meulen, Catharina N., ter Steege, Rinze W.F., Tack, Greetje, Kuyvenhoven, Johan, Jharap, Bindia, Vu, My K., Vogelaar, Lauran, West, Rachel L., van der Marel, Sander, Römkens, Tessa E.H., Mujagic, Zlatan, Hoentjen, Frank, van Bodegraven, Adriaan A., van Schaik, Fiona D.M., de Vries, Annemarie C., and van der Meulen-de Jong, Andrea E.

Abstract

Background: Iron deficiency (ID) and anemia in patients with Inflammatory Bowel Disease (IBD) are associated with a reduced quality of life. We assessed the prevalence of ID and anemia in Dutch outpatients with IBD and compared routine ID(A) management among medical professionals to the European Crohn’s and Colitis Organisation (ECCO) treatment guidelines. Methods: Between January and November 2021, consecutive adult outpatients with IBD were included in this study across 16 Dutch hospitals. Clinical and biochemical data were extracted from medical records. Additionally, medical professionals filled out questionnaires regarding routine ID(A) management. Results: In total, 2197 patients (1271 Crohn’s Disease, 849 Ulcerative Colitis, and 77 IBD-unclassified) were included. Iron parameters were available in 59.3% of cases. The overall prevalence of anemia, ID, and IDA was: 18.0%, 43.4%, and 12.2%, respectively. The prevalence of all three conditions did not differ between IBD subtypes. ID(A) was observed more frequently in patients with biochemically active IBD than in quiescent IBD (ID: 70.8% versus 23.9%; p < 0.001). Contrary to the guidelines, most respondents prescribed standard doses of intravenous or oral iron regardless of biochemical parameters or inflammation. Lastly, 25% of respondents reported not treating non-anemic ID. Conclusions: One in five patients with IBD suffers from anemia that—despite inconsistently measured iron parameters—is primarily caused by ID. Most medical professionals treat IDA with oral iron or standard doses of intravenous iron regardless of biochemical inflammation; however, non-anemic ID is often overlooked. Raising awareness about the management of ID(A) is needed to optimize and personalize routine care.

Published
2022

31. Treat to target versus standard of care for patients with Crohn's disease treated with ustekinumab (STARDUST): an open-label, multicentre, randomised phase 3b trial

Author

Danese, Silvio, primary, Vermeire, Severine, additional, D'Haens, Geert, additional, Panés, Julian, additional, Dignass, Axel, additional, Magro, Fernando, additional, Nazar, Maciej, additional, Le Bars, Manuela, additional, Lahaye, Marjolein, additional, Ni, Lioudmila, additional, Bravata, Ivana, additional, Lavie, Frederic, additional, Daperno, Marco, additional, Lukáš, Milan, additional, Armuzzi, Alessandro, additional, Löwenberg, Mark, additional, Gaya, Daniel R, additional, Peyrin-Biroulet, Laurent, additional, Rocca, Rodolfo, additional, Lopes, Susana, additional, Caprioli, Flavio, additional, Ardizzone, Sandro, additional, Echarri Piudo, Ana, additional, Gionchetti, Paolo, additional, Roblin, Xavier, additional, Seidler, Ursula, additional, Andersson, David, additional, Patel, Kamal, additional, Desreumaux, Pierre, additional, Saibeni, Simone, additional, From, Gustav, additional, Fedurco, Miroslav, additional, Gregus, Milos, additional, Bouhnik, Yoram, additional, Luegering, Andreas, additional, Cosintino, Rocco, additional, Bunganic, Ivan, additional, Ramos, Jaime, additional, Aguas Peris, Mariam, additional, Dewit, Olivier, additional, Principi, Mariabeatrice, additional, Wesley, Emma, additional, Lago, Paula, additional, Nancey, Stephane, additional, Martín Arranz, María Dolores, additional, Hindryckx, Pieter, additional, Orlando, Ambrogio, additional, Geccherle, Andrea, additional, Annunziata, Maria Laura, additional, Hayee, Bu'hussain, additional, Balaz, Jozef, additional, Portela, Francisco, additional, Gilletta, Cyrielle, additional, Kucharzik, Torsten, additional, Mínguez, Miguel, additional, Gisbert, Javier Pérez, additional, Casbas, Ana Gutiérrez, additional, Louis, Edouard, additional, Marino, Marco, additional, Parkes, Gareth, additional, Cummings, Fraser, additional, Jharap, Bindia, additional, Kjeldsen, Jens, additional, Correia, Luís, additional, Ministro, Paula, additional, Ebert, Matthias, additional, Hertervig, Erik, additional, Staessen, Dirk, additional, Dutré, Joris, additional, Colard, Arnaud, additional, Morrison, Graham, additional, Glerup, Henning, additional, Dahlerup, Jens Frederik, additional, Wolfhagen, Frank, additional, Batovsky, Marian, additional, Molnar, Martin, additional, Kadleckova, Barbora, additional, Caldeira, Paulo, additional, Laharie, David, additional, Hebuterne, Xavier, additional, Bonaz, Bruno, additional, Allez, Matthieu, additional, Fischer, Andreas, additional, Hinojosa Del Val, Joaquín Ernesto, additional, Ciria, Miriam Mañosa, additional, Herrera Justiniano, Jose Manuel, additional, Soderman, Charlotte, additional, Chandy, Rajiv, additional, Mowat, Craig, additional, Irving, Peter, additional, Fallingborg, Jan, additional, Matous, Jan, additional, Douda, Tomas, additional, Altwegg, Romain, additional, Benitez, Jose Manuel, additional, Arroyo Villarino, María Teresa, additional, Capón, Jordi Guardiola, additional, Vicenc, Daniel Ginard, additional, Dewint, Pieter, additional, Almer, Sven, additional, and Kindt, Sebastien, additional

Published
2022
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33. Prophylactic Medication for the Prevention of Endoscopic Recurrence in Crohn's Disease: a Prospective Study Based on Clinical Risk Stratification.

Author

Arkenbosch, Jeanine H C, Beelen, Evelien M J, Dijkstra, Gerard, Romberg-Camps, Mariëlle, Duijvestein, Marjolijn, Hoentjen, Frank, van der Marel, Sander, Maljaars, P W Jeroen, Jansen, Sita, Boer, Nanne K H de, West, Rachel L, Horjus, Carmen S, Stassen, Laurents P S, Schaik, Fiona D M van, Ruler, Oddeke van, Jharap, Bindia J H, Visschedijk, Marijn, Janssen, Alfred, Erler, Nicole S, and Doukas, Michail

Abstract

Background To prevent recurrence after ileocolonic resection [ICR] in Crohn's disease [CD], postoperative prophylaxis based on risk stratification is recommended in international guidelines. This study aimed to evaluate postoperative CD recurrence after implementation of a clinical management algorithm and to determine the predictive value of clinical and histological risk factors [RFs]. Methods In this multicentre, prospective cohort study, CD patients [≥16 years] scheduled for ICR were included. The algorithm advised no postoperative medication for low-risk patients, and treatment with prophylaxis [immunosuppressant/biological] for high-risk patients [≥1 RF: active smoking, penetrating disease, prior ICR]. Clinical and histological RFs [active inflammation, granulomas, plexitis in resection margins] for endoscopic recurrence [Rutgeerts' score ≥i2b at 6 months] were assessed using logistic regression and ROC curves based on predicted probabilities. Results In total, 213 CD patients after ICR were included [age 34.5 years; 65% women] (93 [44%] low-risk; 120 [56%] high-risk: 45 [38%] smoking; 51 [43%] penetrating disease; 51 [43%] prior ICR). Adherence to the algorithm was 82% in low-risk [no prophylaxis] and 51% in high-risk patients [prophylaxis]. Endoscopic recurrence was higher in patients treated without prophylaxis than with prophylaxis in both low [45% vs 16%, p = 0.012] and high-risk patients [49% vs 26%, p = 0.019]. Clinical risk stratification including the prescription of prophylaxis corresponded to an area under the curve [AUC] of 0.70 (95% confidence interval [CI] 0.61–0.79). Clinical RFs combined with histological RFs increased the AUC to 0.73 [95% CI 0.64–0.81]. Conclusion Adherence to this management algorithm is 65%. Prophylactic medication after ICR prevents endoscopic recurrence in low- and high-risk patients. Clinical risk stratification has an acceptable predictive value, but further refinement is needed. [ABSTRACT FROM AUTHOR]

Published
2023
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38. Healthy Cotwins Share Gut Microbiome Signatures With Their Inflammatory Bowel Disease Twins and Unrelated Patients

Author

Brand, Eelco C., primary, Klaassen, Marjolein A.Y., additional, Gacesa, Ranko, additional, Vich Vila, Arnau, additional, Ghosh, Hiren, additional, de Zoete, Marcel R., additional, Boomsma, Dorret I., additional, Hoentjen, Frank, additional, Horjus Talabur Horje, Carmen S., additional, van de Meeberg, Paul C., additional, Willemsen, Gonneke, additional, Fu, Jingyuan, additional, Wijmenga, Cisca, additional, van Wijk, Femke, additional, Zhernakova, Alexandra, additional, Oldenburg, Bas, additional, Weersma, Rinse K., additional, Brand, Eelco C., additional, Honkoop, Pieter, additional, Jacobs, Rutger J., additional, Ponsioen, Cyriel Y., additional, de Boer, Nanne K.H., additional, Alderlieste, Yasser A., additional, van Herwaarden, Margot A., additional, van Tuyl, Sebastiaan A.C., additional, Lutgens, Maurice W., additional, Janneke van der Woude, C., additional, Mares, Wout G.M., additional, de Koning, Daan B., additional, Bosman, Joukje H., additional, Vecht, Juda, additional, de Schryver, Anneke M.P., additional, van der Meulen-de Jong, Andrea E., additional, Pierik, Marieke J., additional, Boekema, Paul J., additional, Verburg, Robert J., additional, Jharap, Bindia, additional, Jansen, Jeroen M., additional, Stokkers, Pieter C.F., additional, Quispel, Rutger, additional, Mahmmod, Nofel, additional, West, Rachel L., additional, Willems, Marleen, additional, Minderhoud, Itta M., additional, Fidder, Herma H., additional, van Schaik, Fiona D.M., additional, Hirdes, Meike M.C., additional, Boontje, Nynke A., additional, Müskens, Bart L.M., additional, and Romberg-Camps, Marielle J.L., additional

Published
2021
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40. Loss of response to anti-TNF alpha agents depends on treatment duration in patients with inflammatory bowel disease

Author

MS MDL 1, Unit Opleiding MDL, Infection & Immunity, Cancer, Schultheiss, Johannes P D, Mahmoud, Remi, Louwers, Jonas M, van der Kaaij, Michiel T, van Hellemondt, Boris P, van Boeckel, Petra G, Mahmmod, Nofel, Jharap, Bindia, Fidder, Herma H, Oldenburg, Bas, MS MDL 1, Unit Opleiding MDL, Infection & Immunity, Cancer, Schultheiss, Johannes P D, Mahmoud, Remi, Louwers, Jonas M, van der Kaaij, Michiel T, van Hellemondt, Boris P, van Boeckel, Petra G, Mahmmod, Nofel, Jharap, Bindia, Fidder, Herma H, and Oldenburg, Bas

Published
2021

41. Continuation of Anti-TNF in Patients With Ulcerative Colitis in Remission Is Not Cost-effective Compared With Treatment Withdrawal: a Markov Model

Author

MS MDL 1, HEE, Child Health, JC onderzoeksprogramma Methodologie, Infection & Immunity, Mahmoud, Remi, van Lieshout, Chris, Frederix, Geert W J, Jharap, Bindia, Oldenburg, Bas, MS MDL 1, HEE, Child Health, JC onderzoeksprogramma Methodologie, Infection & Immunity, Mahmoud, Remi, van Lieshout, Chris, Frederix, Geert W J, Jharap, Bindia, and Oldenburg, Bas

Published
2021

42. Reply

Author

Mahmoud, Remi, Savelkoul, Edo H.J., Jharap, Bindia, and Oldenburg, Bas

Published
2023
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44. Clinical Outcomes of Covid-19 in Patients With Inflammatory Bowel Disease: A Nationwide Cohort Study

Author

Derikx, Lauranne A A P, primary, Lantinga, Marten A, additional, de Jong, Dirk J, additional, van Dop, Willemijn A, additional, Creemers, Rob H, additional, Römkens, Tessa E H, additional, Jansen, Jeroen M, additional, Mahmmod, Nofel, additional, West, Rachel L, additional, Tan, Adriaan C I T L, additional, Bodelier, Alexander G L, additional, Gorter, Moniek H P, additional, Boekema, Paul J, additional, Halet, Eric R C, additional, Horjus, Carmen S, additional, van Dijk, Maarten A, additional, Hirdes, Meike M C, additional, Epping Stippel, Ludger S M, additional, Jharap, Bindia, additional, Lutgens, Maurice W M D, additional, Russel, Maurice G, additional, Gilissen, Lennard P L, additional, Nauta, Sjoukje, additional, van Bodegraven, Adriaan A, additional, and Hoentjen, Frank, additional

Published
2020
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48. Limited relevance and progression of histological alterations in the liver during thioguanine therapy in inflammatory bowel disease patients

Author

van Asseldonk, Dirk P., primary, Simsek, Melek, additional, de Boer, Nanne K. H., additional, Jharap, Bindia, additional, Bloemena, Elisabeth, additional, den Hartog, Gijsbert, additional, Westerveld, Dik B., additional, Becx, Marco C., additional, Russel, Maurice G., additional, Lissenberg-Witte, Birgit I., additional, van Nieuwkerk, Carin M., additional, Mulder, Chris J. J., additional, Verheij, Joanne, additional, and van Bodegraven, Adriaan A., additional

Published
2019
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49. Infants born to mothers with IBD present with altered gut microbiome that transfers abnormalities of the adaptive immune system to germ-free mice

Author

Torres, Joana, primary, Hu, Jianzhong, additional, Seki, Akihiro, additional, Eisele, Caroline, additional, Nair, Nilendra, additional, Huang, Ruiqi, additional, Tarassishin, Leonid, additional, Jharap, Bindia, additional, Cote-Daigneault, Justin, additional, Mao, Qixing, additional, Mogno, Ilaria, additional, Britton, Graham J, additional, Uzzan, Mathieu, additional, Chen, Ching-Lynn, additional, Kornbluth, Asher, additional, George, James, additional, Legnani, Peter, additional, Maser, Elana, additional, Loudon, Holly, additional, Stone, Joanne, additional, Dubinsky, Marla, additional, Faith, Jeremiah J, additional, Clemente, Jose C, additional, Mehandru, Saurabh, additional, Colombel, Jean-Frederic, additional, and Peter, Inga, additional

Published
2019
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50. Safety and efficacy of the immunosuppressive agent 6-tioguanine in murine model of acute and chronic colitis

Author

van Bodegraven Adriaan A, Vos Rene M, de Boer Nanne K, Jharap Bindia, Klimesova Klara, Tlaskalova-Hogenova Helena, Rossmann Pavel, Kverka Miloslav, Lukas Milan, and Mulder Chris J

Subjects
Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Abstract Background Oral thiopurines are effective and widely used in treatment of inflammatory bowel disease (IBD) in humans, although their use is limited due the development of adverse events. Here, we examine the efficacy and toxicity of oral treatment with 6-tioguanine (6-TG) and azathioprine (AZA) in a murine model of IBD. Methods We induced acute or chronic colitis in BALB/c mice by one or four cycles of 3% dextran sulphate sodium (DSS), respectively. Mice were treated by daily gavages of various dosages of 6-tioguanine, azathioprine, or by phosphate buffered saline (PBS) starting the first day of DSS or after two cycles of DSS, respectively. We monitored the efficacy and toxicity by measuring the weight change and serum alanine aminotransferase (ALT) activity and by disease severity and histology, at the end of the experiment. Moreover, we measured cytokine production after colon fragment cultivation by enzyme-linked immunoabsorbent assay and numbers of apoptotic cells in the spleen by flow cytometry. Results 6-TG is effective in the treatment of acute DSS-induced colitis in a dose-dependent manner and 40 μg of 6-TG is significantly more effective in the treatment of acute colitis than both AZA and PBS. This effect is accompanied by decrease of IL-6 and IFN-γ production in colon. We did not observe histological abnormalities in liver samples from control (PBS) or 6-TG treated mice. However, liver samples from most mice treated with AZA showed mild, yet distinct signs of hepatotoxicity. In chronic colitis, all thiopurine derivatives improved colitis, 20 μg of 6-TG per dose was superior. High doses of 6-TG led to significant weight loss at the end of the therapy, but none of the thiopurine derivatives increased levels of serum ALT. Both thiopurine derivatives reduced the proportion of apoptotic T helper cells, but a high production of both IL-6 and TGF-β was observed only in colon of AZA-treated mice. Conclusions Use of 6-TG in the treatment of experimental colitis in mice appears superior to AZA administration and placebo. In contrast to 6-TG, the use of AZA resulted in histological liver abnormalities.

Published
2011
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