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1. The role of the ALKBH5 RNA demethylase in invasive breast cancer

Author

Woodcock, Corinne L., Alsaleem, Mansour, Toss, Michael S., Lothion-Roy, Jennifer, Harris, Anna E., Jeyapalan, Jennie N., Blatt, Nataliya, Rizvanov, Albert A., Miftakhova, Regina R., Kariri, Yousif A., Madhusudan, Srinivasan, Green, Andrew R., Rutland, Catrin S., Fray, Rupert G., Rakha, Emad A., and Mongan, Nigel P.

Published
2024
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2. The role of the ALKBH5 RNA demethylase in invasive breast cancer

Author

Corinne L. Woodcock, Mansour Alsaleem, Michael S. Toss, Jennifer Lothion-Roy, Anna E. Harris, Jennie N. Jeyapalan, Nataliya Blatt, Albert A. Rizvanov, Regina R. Miftakhova, Yousif A. Kariri, Srinivasan Madhusudan, Andrew R. Green, Catrin S. Rutland, Rupert G. Fray, Emad A. Rakha, and Nigel P. Mongan

Subjects
N6-methyladenosine, Epitranscriptomics, m6A, Prognosis, Breast cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background N6-methyladenosine (m6A) is the most common internal RNA modification and is involved in regulation of RNA and protein expression. AlkB family member 5 (ALKBH5) is a m6A demethylase. Given the important role of m6A in biological mechanisms, m6A and its regulators, have been implicated in many disease processes, including cancer. However, the contribution of ALKBH5 to invasive breast cancer (BC) remains poorly understood. The aim of this study was to evaluate the clinicopathological value of ALKBH5 in BC. Methods Publicly available data were used to investigate ALKBH5 mRNA alterations, prognostic significance, and association with clinical parameters at the genomic and transcriptomic level. Differentially expressed genes (DEGs) and enriched pathways with low or high ALKBH5 expression were investigated. Immunohistochemistry (IHC) was used to assess ALKBH5 protein expression in a large well-characterised BC series (n = 1327) to determine the clinical significance and association of ALKBH5 expression. Results Reduced ALKBH5 mRNA expression was significantly associated with poor prognosis and unfavourable clinical parameters. ALKBH5 gene harboured few mutations and/or copy number alternations, but low ALKBH5 mRNA expression was seen. Patients with low ALKBH5 mRNA expression had a number of differentially expressed genes and enriched pathways, including the cytokine-cytokine receptor interaction pathway. Low ALKBH5 protein expression was significantly associated with unfavourable clinical parameters associated with tumour progression including larger tumour size and worse Nottingham Prognostic Index group. Conclusion This study implicates ALKBH5 in BC and highlights the need for further functional studies to decipher the role of ALKBH5 and RNA m6A methylation in BC progression.

Published
2024
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3. Epitranscriptomic mechanisms of androgen signalling and prostate cancer

Author

Rodhan Patke, Anna E. Harris, Corinne L. Woodcock, Rachel Thompson, Rute Santos, Amber Kumari, Cinzia Allegrucci, Nathan Archer, Lorraine J. Gudas, Brian D. Robinson, Jenny L. Persson, Rupert Fray, Jennie Jeyapalan, Catrin S. Rutland, Emad Rakha, Srinivasan Madhusudan, Richard D. Emes, Musalwa Muyangwa-Semenova, Mansour Alsaleem, Simone de Brot, William Green, Hari Ratan, Nigel P. Mongan, and Jennifer Lothion-Roy

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Prostate cancer (PCa) is the second most common cancer diagnosed in men. While radical prostatectomy and radiotherapy are often successful in treating localised disease, post-treatment recurrence is common. As the androgen receptor (AR) and androgen hormones play an essential role in prostate carcinogenesis and progression, androgen deprivation therapy (ADT) is often used to deprive PCa cells of the pro-proliferative effect of androgens. ADTs act by either blocking androgen biosynthesis (e.g. abiraterone) or blocking AR function (e.g. bicalutamide, enzalutamide, apalutamide, darolutamide). ADT is often effective in initially suppressing PCa growth and progression, yet emergence of castrate-resistant PCa and progression to neuroendocrine-like PCa following ADT are major clinical challenges. For this reason, there is an urgent need to identify novel approaches to modulate androgen signalling to impede PCa progression whilst also preventing or delaying therapy resistance.The mechanistic convergence of androgen and epitranscriptomic signalling offers a potential novel approach to treat PCa. The epitranscriptome involves covalent modifications of mRNA, notably, in the context of this review, the N(6)-methyladenosine (m6A) modification. m6A is involved in the regulation of mRNA splicing, stability, and translation, and has recently been shown to play a role in PCa and androgen signalling. The m6A modification is dynamically regulated by the METTL3-containing methyltransferase complex, and the FTO and ALKBH5 RNA demethylases.Given the need for novel approaches to treat PCa, there is significant interest in new therapies that target m6A that modulate AR expression and androgen signalling. This review critically summarises the potential benefit of such epitranscriptomic therapies for PCa patients.

Published
2024
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5. Alliance A071401: Phase II Trial of Focal Adhesion Kinase Inhibition in Meningiomas With Somatic NF2 Mutations.

Author

Monga, Varun, Fadul, Camilo, Schiff, David, Taylor, Jennie, Chowdhary, Sajeel, Bettegowda, Chetan, Ansstas, George, De La Fuente, Macarena, Anderson, Mark, Shonka, Nicole, Damek, Denise, Carrillo, Jose, Kunschner-Ronan, Lara, Chaudhary, Rekha, Jaeckle, Kurt, Senecal, Francis, Kaley, Thomas, Morrison, Tara, Thomas, Alissa, Welch, Mary, Iwamoto, Fabio, Cachia, David, Cohen, Adam, Vora, Shivangi, Knopp, Michael, Dunn, Ian, Kumthekar, Priya, Sarkaria, Jann, Geyer, Susan, Carrero, Xiomara, Martinez-Lage, Maria, Cahill, Daniel, Brown, Paul, Giannini, Caterina, Santagata, Sandro, Barker, Frederick, Galanis, Evanthia, Brastianos, Priscilla, Twohy, Erin, Gerstner, Elizabeth, Kaufmann, Timothy, Iafrate, A, Lennerz, Jochen, Jeyapalan, Suriya, and Piccioni, David

Subjects
Humans, Focal Adhesion Protein-Tyrosine Kinases, Meningeal Neoplasms, Meningioma, Mutation, Neoplasm Recurrence, Local
Abstract

PURPOSE: Patients with progressive or recurrent meningiomas have limited systemic therapy options. Focal adhesion kinase (FAK) inhibition has a synthetic lethal relationship with NF2 loss. Given the predominance of NF2 mutations in meningiomas, we evaluated the efficacy of GSK2256098, a FAK inhibitor, as part of the first genomically driven phase II study in recurrent or progressive grade 1-3 meningiomas. PATIENTS AND METHODS: Eligible patients whose tumors screened positively for NF2 mutations were treated with GSK2256098, 750 mg orally twice daily, until progressive disease. Efficacy was evaluated using two coprimary end points: progression-free survival at 6 months (PFS6) and response rate by Macdonald criteria, where PFS6 was evaluated separately within grade-based subgroups: grade 1 versus 2/3 meningiomas. Per study design, the FAK inhibitor would be considered promising in this patient population if either end point met the corresponding decision criteria for efficacy. RESULTS: Of 322 patients screened for all mutation cohorts of the study, 36 eligible and evaluable patients with NF2 mutations were enrolled and treated: 12 grade 1 and 24 grade 2/3 patients. Across all grades, one patient had a partial response and 24 had stable disease as their best response to treatment. In grade 1 patients, the observed PFS6 rate was 83% (10/12 patients; 95% CI, 52 to 98). In grade 2/3 patients, the observed PFS6 rate was 33% (8/24 patients; 95% CI, 16 to 55). The study met the PFS6 efficacy end point both for the grade 1 and the grade 2/3 cohorts. Treatment was well tolerated; seven patients had a maximum grade 3 adverse event that was at least possibly related to treatment with no grade 4 or 5 events. CONCLUSION: GSK2256098 was well tolerated and resulted in an improved PFS6 rate in patients with recurrent or progressive NF2-mutated meningiomas, compared with historical controls. The criteria for promising activity were met, and FAK inhibition warrants further evaluation for this patient population.

Published
2023

6. The Factors Causing Stress in Medical Students and their Impact on Academic Outcomes: A Narrative Qualitative Systematic Review

Author

Thensiniya Jeyapalan and Erik Blair

Subjects
Psychological Stressors, Medical Students, Medical School, Analysis, Stress, Academic Outcomes, Medicine (General), R5-920, Public aspects of medicine, RA1-1270
Abstract

Background: This study investigated the causes of stress in medical students and the impact of stress on their academic outcomes. Much is known about the impact of stress on medical students but there is a gap in knowledge regarding the collated overview of literature in this area. This study sought to pull together disparate research to gain a clearer overview of the core drivers of stress. Methods: Taking a meta-level approach, a narrative qualitative systematic review of previous systematic reviews was undertaken, following the PRISMA guidelines. This systematic review covered literature published from 2009-2023 where the focus was stress in students studying at medical schools in the United Kingdom. Findings were then assessed for commonly emerging themes. Results: From an initial tranche of 3394 articles, a final set of eight systematic reviews was identified. The eight reviews drew on over 309 separate research projects and involved over 500,000 participants. A review of the key findings from each of the eight studies identified five themes: academic pressure, the impact of the institution, students’ personality traits, social relationships, and financial stress. The analysis provided clear evidence that stress amongst medical students results in negative academic outcomes. Conclusion: The findings suggest a need to reduce stress to help medical students prevent a decline in their academic outcomes and health. From these findings it is recommended that medical schools examine their curriculum to identify areas where they feel they put undue academic pressure on their students and work on ways to remediate this situation.

Published
2024
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7. Epitranscriptomic mechanisms of androgen signalling and prostate cancer

Author

Patke, Rodhan, Harris, Anna E., Woodcock, Corinne L., Thompson, Rachel, Santos, Rute, Kumari, Amber, Allegrucci, Cinzia, Archer, Nathan, Gudas, Lorraine J., Robinson, Brian D., Persson, Jenny L., Fray, Rupert, Jeyapalan, Jennie, Rutland, Catrin S., Rakha, Emad, Madhusudan, Srinivasan, Emes, Richard D., Muyangwa-Semenova, Musalwa, Alsaleem, Mansour, de Brot, Simone, Green, William, Ratan, Hari, Mongan, Nigel P., and Lothion-Roy, Jennifer

Published
2024
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9. Immunocompromised-Associated Pediatric Acute Respiratory Distress Syndrome: Experience From the 2016/2017 Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology Prospective Cohort Study*

Author

Gertz, Shira J., Bhalla, Anoopindar, Chima, Ranjit S., Emeriaud, Guillaume, Fitzgerald, Julie C., Hsing, Deyin D., Jeyapalan, Asumthia S., Pike, Francis, Sallee, Colin J., Thomas, Neal J., Yehya, Nadir, Rowan, Courtney M., Sforza, Jesica, Poterala, Rossana, Fernandez, Analia, Avila Vera, Antonio, Orqueda, Daniel, Agueda Vidal, Nilda, Rosemary, Deheza, Turon, Gonzalo, Monjes, Cecilia, Fernando Espanol, Segundo, Siaba Serrate, Alejandro, Iolster, Thomas, Torres, Silvio, Cinquegrani, Karina, Jose Montes, Maria, Capocasa, Patricia, Ferreyra, Marcela, Castellani, Pablo, Giampieri, Martin, Pedraza, Claudia, Martin Landry, Luis, Althabe, Maria, Vanesa Fortini, Yanina, Botta, Priscila, Paziencia, Fernando, Erickson, Simon, Barr, Samantha, Shea, Sara, Butt, Warwick, Delzoppo, Carmel, Pintimalla, Alyssa, Martinez Leon, Alejandro Fabio, Guzman Rivera, Gustavo Alfredo, Jouvet, Philippe, Emeriaud, Guillaume, Dumitrascu, Mariana, Ellen French, Mary, Caro, Daniel, Castillo, I, Andres, E., Cruces Romero, Pablo, Medina, Tania, Pavez Madrid, Paula, Cortez, Ambar, Alvear, Jimena, Acuna, Carlos, Diaz, Franco, Jose Nunez, Maria, Wegner Araya, Adriana, Godoy Mundaca, Loreto, Chen, Yang, Perez Lozano, German, Pardo Carrero, Rosalba, Lopez Alarcon, Yurika Paola, Mazzillo Vega, Liliana, Maria Izquierdo, Ledys, Piñeres Olave, Byron Enrique, Zuluaga Orrego, Cesar, Quinonez Lopez, Deyanira, Vasquez Hoyos, Pablo, Vavrina, Martin, Zurek, Jiri, Campos-Miño, Santiago, Yerovi, Rocio, Bridier, Armelle, Payen, Valerie, Milesi, Christophe, Bourgoin, Pierre, Travert, Brendan, Genuini, Mathieu, Starck, Julie, Maria, Matthieu, Guichoux, Julie, Baudin, Florent, Briassoulis, George, Ilia, Stavroula, Di Nardo, Matteo, Camporesi, Anna, Chiusolo, Fabrizio, Shime, Nobuaki, Ohshimo, Shinichiro, Kida, Yoshiko, Kyo, Michihito, Tabata, Yuichi, Fong Tang, Swee, Wern Tai, Chian, See Lum, Lucy Chai, Elghuwael, Ismail, Jimenez Rivera, Nestor Javier, Jarillo Quijada, Alberto E, Kneyber, Martin, Dijkstra, Sandra, Beca, John, Sherring, Claire, Miriam, Rea, Vargas G, Sonia I, Vasquez Miranda, Daniel, Ramirez Cortez, Grimaldo, Tantalean, Jose, Pagowska-Klimek, Izabela, Gil Escobar, Carlos, Sousa Moniz, Marta, Camilo, Cristina, Hazwani, Tarek, Aldairi, Nedaa, Al Amoudi, Ahmed, Alahmadti, Ahmad, Taylor, Ryan, Mendizabal, Mikel, Goni Orayen, Concepcion, Lopez Fernandez, Yolanda, Ramon Valle, Juan, Martinez, Lidia, Pilar Orive, Javier, Brezmes, Marta, Lopez-Herce, Jesus, Parrilla, Julio, Gaboli, Mirella, Gonzalez Gomez, Jose Manuel, Morales Martinez, Antonio, Alapont, Vicent Modesto I, Sanchez Diaz, Juan Ignacio, Llorente de la Fuente, Ana M., Palanca Arias, Daniel, Madurga Revilla, Paula, Martinez de Azagra, Amelia, Garcia Gonzalez, Maria, Arjona Villanueva, David, Garcia Casas, Paula, Brio Sanagustin, Sonia, Pons Odena, Marti, Medina, Alberto, Onate Vergara, Eider, Rodriguez Campoy, Patricia, Reyes Dominguez, Susana, Dursun, Oguz, Atike Ongun, Ebru, Kamit Can, Fulya, Berna Anil, Ayse, Baines, Paul, Walsh, Laura, Jones, Dawn, Sadasivam, Kalaimaran, Mildner, Reinout, Plunkett, Adrian, Lillie, Jon, Tibby, Shane, Wellman, Paul, Belfield, Holly, Brierley, Joe, Dominguez, Troy E., Abaleke, Eugenia, Feinstein, Yael, Deep, Akash, Sundararajan, Santosh, Oruganti, Siva, Silvestre, Catarina, Weitz, James, Sheward, Victoria, Macrae, Duncan, Aramburo, Angela, Fortune, Peter-Marc, Subramanian, Gayathri, Jennings, Claire, Dwarakanathan, Buvana, Inwald, David, Feather, Calandra, Agbeko, Rachel, Lawton-Woodhall, Angela, McIntyre, Karen, Sykes, Kim, Pappachan, Jon, Gale, Helen, Mellish, Christie, McCorkell, Jenni, Torero, Luis, Nofziger, Ryan, Latifi, Samir, Anthony, Heather, Sanders, Ron, Hefley, Glenda, Virk, Manpreet, Jaimon, Nancy, Maddux, Aline B., Mourani, Peter M., Ralston, Kimberly, Sierra, Yamila, Khemani, Robinder, Newth, Christopher, Bhalla, Anoopindar, Kwok, Jeni, Morzov, Rica, Mahapatra, Sidharth, Truemper, Edward, Kustka, Lucinda, Nett, Sholeen T., Singleton, Marcy, Dean Jarvis, J., Yehya, Nadir, Napolitano, Natalie, Murphy, Marie, Ronan, Laurie, Morgan, Ryan, Kubis, Sherri, Broden, Elizabeth, Willson, Douglas, Henderson, Grace, Gedeit, Rainer, Murkowski, Kathy, Woods, Katherine, Kasch, Mary, Han, Yong Y, Affolter, Jeremy T, Tieves, Kelly S, Hughes-Schalk, Amber, Chima, Ranjit S., Krallman, Kelli, Stoneman, Erin, Benken, Laura, Yunger, Toni, Schneider, James, Sweberg, Todd, Kessel, Aaron, Carroll, Christopher L., Santanelli, James, Ackerman, Kate G, Cullimore, Melissa, Rowan, Courtney, Bales, Melissa, Keith Dockery, W., Jafari-Namin, Shirin, Barry, Dana, Jane’t, Keary, Alibrahim, Omar, Patankar, Nikhil, Qiao, Haiping, Gertz, Shira, Su, Felice, Haileselassie, Bereketeab, Song, Hanqiu, Bysani, Kris, Monjure, Tracey, Beltramo, Fernando, Totapally, Balagangadhar, Govantes, Beatriz, Coates, Bria, Wellisch, Lawren, Allen, Kiona, Shukla, Avani, Thomas, Neal J., Spear, Debbie, Shein, Steven L., Gertz, Shira, Parker, Margaret M., Sloniewsky, Daniel, Allen, Christine, Harrell, Amy, Pinto, Neethi, Kniola, Allison, Rodgers, Chiara, Cvijanovich, Natalie, Typpo, Katri, Kelley, Connor, King, Caroline, Sapru, Anil, Ratiu, Anna, Ashtari, Neda, Sikora, Lindsay, Jeyapalan, Asumthia S., Coronado-Munoz, Alvaro, Flori, Heidi, Dahmer, Mary K., Jayachandran, Chaandini, Hume, Janet, Nerheim, Dan, Smith, Rebecca, Spaeder, Michael, Adu-Darko, Michelle, Smith, Lincoln, Hartmann, Silvia, Sullivan, Erin, Merritt, Courtney, Al-Subu, Awni, Blom, Andrea, Lin, John C., Spinella, Philip, Hsing, Deyin D., Pon, Steve, Brian Estil, Jim, Gautam, Richa, Giuliano, John S., Jr, and Tala, Joana

Published
2024
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10. Dedicated anticoagulation management protocols in fragility femoral fracture care – a source of significant variance and limited effectiveness in improving time to surgery: The hip and femoral fracture anticoagulation surgical timing evaluation (HASTE) study

Author

Smith, Matthew, Yoong, Andrel, Lim, Jun Wei, Yousef, Omar, McDonald, Stephen, Chileshe, Chinga, Ramus, Camilla, Clements, Christopher, Barrett, Liam, Rockall, Oliver, Geetala, Rahul, Islam, Saif Ul, Nasar, Ahmad, Almond, Kieran, Hassan, Ladan Fatima Yusuf, Shah, Sohan, Brand, Robert Bruce, Yawar, Bakhat, Gilmore, Catherine, McAuley, Daryl, Khan, Waleed, Subramanian, Padmanabhan, Ahluwalia, Aashish, Ozbek, Leyla, Awasthi, Prashant, Sheikh, Hassaan, Barkley, Sarah, Ardolino, Toni, Denning, Alexander, Thiruchandran, Gaj, Fraig, Hossam, Salim, Omar, Iqbal, Rabia, Guy, Stephen, Hogg, Jack, Bagshaw, Oliver, Asmar, Samir, Mitchell, Stephen, Quek, Fang, Fletcher, James, French, Jonathan, Graham, Selina, Sloper, Philip, Sadique, Hammad, Matera, Valentina, Sohail, Zain, Leong, Justin Wei, Issa, Fares, Greasley, Lauren, Marsden, Samuel, Parry, Lucy, Mannan, Syed, Zaheen, Humayoon, Moriarty, Peter, Manning, William, Morris, Timothy, Brockbanks, Carole, Ward, Peter, Pearce, Kim, McMenemy, Louise, Mahmoud, Mohamed, Kieffer, Will, Lal, Aayush, Collis, Justin, Chandrasekaran, Karthik, Foxall-Smith, Michael, Raad, Marjan, Kempshall, Peter, Cheuk, Jocelyn, Leckey, Sam, Gupta, Rishav, Engelke, Daniel, Kemp, Mark, Venkatesan, Aakaash, Hussain, Adnan, Simons, Michiel, Raghavendra, Ram Mohan, Rohra, Satish, Deo, Sunny, Vasarhelyi, Ferenc, Thelwall, Claire, Cullen, Krista, Al-Obaidi, Bilal, Fell, Adam, Thaumeen, Ahmad, Dadabhoy, Maria, Ali, Mira, Ijaz, Sameer, Lin, David, Khan, Basharat, Alsonbaty, Mohamed, Lebe, Moritz, Millan, Ravi Kant, Imam, Sam, Theobald, Emma, Cormack, Jonathan, Sharoff, Lokesh, Eardley, Will, Jeyapalan, Rathan, Alcock, Liam, Clayton, Julia, Bates, Natalie, Mahmoud, Yousif, Osborne, Alex, Ralhan, Shvaita, Carpenter, Catriona, Ahmad, Mahmood, Ravi, Sanjeev Musuvathy, Konbaz, Tarek, Lloyd, Thomas, Sheikh, Nomaan, Swealem, Ahmed, Soroya, Emma, Rayan, Faizal, Ward, Thomas, Vasireddy, Aswinkumar, Clarke, Ellisiv, Sikdar, Oishi, Smart, Yat Wing, Windley, Joseph, Ilagan, Belen, Brophy, Edel, Joseph, Sarah, Lowery, Kathryn, Jamjoom, Ammer, Ismayl, Ghiath, Aujla, Randeep, Sambhwani, Sharan, Ramasamy, Arul, Khalaf, Ahmed, Ponugoti, Nikhil, Teng, Wai Huang, Masud, Saqib, Otoibhili, Eghe, Clarkson, Martin, Nafea, Mohamed, Sarhan, Mohamed, Hanna, Shady, Kelly, Andrew, Curtis, Alex, Gourbault, Lysander, Tarhini, Mariam, Platt, Nicholas, Fleming, Thomas, Pemmaraju, Gopalakrishna, Choudri, Mohammed Junaid, Burahee, Abdus, Hassan, Labiba, Hamid, Laveeza, Loveday, David, Edres, Kareem, Schankat, Kerstin, Granger, Luke, Goodbun, Matthew, Parikh, Sunny, Johnson-Lynn, Sarah, Griffiths, Alexandra, Rai, Avinash, Chandler, Henry, Guiot, Luke, Appleyard, Thomas, Robinson, Karen, Fong, Angus, Watts, Anna, Stedman, Tobias, Walton, Victoria, Inman, Dominic, Liaw, Frank, Hadfield, James, McGovern, Julia, Baldock, Thomas, White, Jonathan, Seah, Matthew, Jacob, Neville, Ali, Zaid Haj, Goff, Thomas, Sanalla, Ahmed, Gomati, Ayoub, Nordin, Louise, Hassan, Eslam, Ramadan, Omar, Teoh, Kar Hao, Baskaran, Dinnish, Ngwayi, James, Abbakr, Lina, Blackmore, Noah, Mansukhani, Sameer, Guryel, Enis, Harper, Adam, Cashman, Emily, Brooker, Joanne, Pack, Louise, Regan, Nora, Wagner, Wilhelm, Selim, Amr, Archer, Debbie, McConaghie, Gregory, Patel, Ravi, Gibson, William, Pasapula, Chandra S, Youssef, Hesham, Aziz, Md Abdul, Subhash, Sadhin, Banaszkiewicz, Paul, Elzawahry, Ahmed, Neo, Chryssa, Wei, Nicholas, Bhaskaran, Arun, Sharma, Abhishek, Factor, Danielle, Shahin, Fatma, Shields, David, Ferreira, Catarina Dores Fernandes, Jeyakumar, Gowsikan, Liao, Quintin, Sinnerton, Robert, Ashwood, Neil, Sarhan, Islam, Ker, Andrew, Phelan, Sean, Paxton, James, McAuley, Joseph, Moulton, Lawrence, Mohamed, Ahmed, Dias, Ana, Ho, Beatrice, Francis, Daniel, Miller, Sarah, Phillips, Jon, Jones, Robin, Arthur, Calum, Oag, Erlend, Thutoetsile, Kamogelo, Bell, Katrina, Milne, Kirsty, Whitefield, Reiss, Patel, Kuntal, Singh, Abhimanyu, Morris, Geraint, Parkinson, Dawn, Patil, Amogh, Hamid, Hassan, Syam, Kevin, Singh, Rohit, Menon, Deepak, Crooks, Sophie, Borland, Steven, Rohman, Adam, Nicholson, Alys, Smith, Ben, Hafiz, Nauman, Kolhe, Shivam, Waites, Matthew, Piper, Dani, Westacott, David, Grimshaw, Jessica, Bott, Alasdair, Berry, Alexander, Battle, Joseph, Flannery, Oliver, Iyengar, Karthikeyan P, Thakur, Abdul Wadood, Yousef, Mina, Bansod, Vaibhav, El-nahas, Walaa, Dawe, Edward, Oladeji, Emmanuel, Federer, Simon, Trompeter, Alex, Pritchard, Anna, Shurovi, Badrun, Jordan, Chris, Little, Max, Sivaloganathan, Sivanshankar, Shaunak, Shalin, Watters, Hazel, Luck, Joshua, Zbaeda, Mohamed, Frasquet-Garcia, Antonio, Warner, Christian, Telford, Jeremy, Rooney, Joanna, Attwood, Joseph, Wilson, Faye, Panagiotopoulos, Andreas, Keane, Conal, Scott, Helen, Mazel, Rebecca, Maggs, Joanna, Skinner, Edward, McMunn, Finlay, Lau, Joshua, Ravikumar, Kasetti, Thakker, Dev, Gill, Moneet, McCarthy, Phillip, Fossey, Gavin, Shah, Sohaib, McAlinden, Gavan, McGoldrick, Peter, O'Brien, Scarlett, Patil, Sunit, Millington, Antonia, Umar, Hamza, Sehdev, Simran, Dyer-Hill, Thomas, Yu Kwan, Tsun, Tanagho, Andy, Hagnasir, Ahmed, White, Thomas, Bano, Christopher, Kissin, Eleanor, Ghani, Rafia, Thomas, Philip S W, McMullan, Mark, Walmsley, Matthew, Elgendy, Mohamed, Winstanley, Robert, Round, Joanne, Baxter, Mark, Thompson, Emett, Hogan, Kathryn, Youssef, Khaled, Fetouh, Sherif, Hopper, Graeme P, Simpson, Cameron, Warren, Craig, Waugh, Dominic, Nair, Gopikrishnan, Ballantyne, Andy, Blacklock, Calum, O'Connell, Ciara, Toland, Gemma, McIntyre, Joshua, Ross, Lauren, Badge, Ravindra, Loganathan, Deeraj, Turner, Ian, Ball, Matthew, Maqsood, Saad, Deierl, Krisztian, Beer, Alexander, Tan, Arthur Chen Wun, Mackinnon, Thomas, Gade, Venkat, Gill, James, Yu San, Kay, Archunan, Maheswaran Warren, Shaikh, Mariyam, Ugbah, Onyinye, Uwaoma, Sade, Pillai, Anand, Nath, Upamanyu, Rohan, Farhan-Alanie, M. M., Dixon, J., Irvine, S., Walker, R., and Eardley, W. G. P.

Published
2024
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11. Antipsychotic use and associating factors among persons with substance-induced psychosis and first-episode psychotic disorders. A nationwide register-linkage study

Author

J. Jeyapalan, S. Niemela, and H. Taipale

Subjects
Psychiatry, RC435-571
Abstract

Introduction Far less is known about the preceding factors of antipsychotic use among persons with substance-induced psychosis (SIP) and first-episode psychosis (FEP). There is no prevention research on how persons with SIP differ from persons with other psychosis episodes like FEP. Antipsychotic medication is the general essential and necessary element in the treatment of SIP and FEP1. Antipsychotics are used as first-line therapy, commencing with a low dose and titrating upwards2. There are no exciting treatment guidelines for treating Substance-induced psychosis in the long term. (A review of some studies published by the Oxford Journals Schizophrenic Bulletin indicated that drug-induced psychosis lasted longer than a month in individuals between 1 and 15% of the time.3) The aim of the study was to investigate antipsychotic use and associated factors in persons with SIP and compare it with persons with other FEP Objectives 1 To study the antipsychotic use among persons with SIP compared with FEP from 3 years before until three years after their first diagnosis first incident of psychosis) 2.To study associating background factors with antipsychotic use among patients with SIP Methods Incident Swedish SIP cases (n=7320)during 2006-2016 were identified from health care registers and matched 1: with persons with FEP (n=7320) by age, gender, and calendar year of diagnosis. Prevalence of antipsychotic use was assessed as point prevalence every six months, from 3years before until 3years after the first diagnosis. Factors associating with antipsychotic use among SIP were analyzed with multivariable logistic regression, including information on sociodemographic and work-related background, including disability pension and sickness absence, SIP types, and psychiatric diagnoses. Results Among SIP and FEP, the prevalence of antipsychotic use was low before the first diagnosis (3-7% in SIP, 8-16% in FEP), peaked 6 months after the first diagnosis (23% in SIP, 54% in FEP) and stabilized after that. After 3 years of first diagnosis, 19% of persons with SIP and 45% of persons with FEP used antipsychotics. Antipsychotic use one year after diagnosis among SIP was associated with previous substance use disorder, depression, anxiety, and personality disorder diagnoses, being on disability pension or on long-term sickness absence (>90 days), and cannabis- or multi-substance-induced psychosis. Image: Image 2: Conclusions As expected, patients with FEP were using more frequently antipsychotics compared to SIP except for long-acting antipsychotics. Although SIP is considered short-lived, antipsychotic use after an incident SIP episode is relatively common, especially among those with cannabis SIP with the highest prevalence of antipsychotic use. Previous substance use disorder and cannabis SIP were highly associated with patients who use antipsychotics frequently. Disclosure of Interest None Declared

Published
2024
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12. The impact of anticoagulant medications on fragility femur fracture care: The hip and femoral fracture anticoagulation surgical timing evaluation (HASTE) study

Author

Smith, Matthew, Yoong, Andrel, Lim, Jun Wei, Yousef, Omar, McDonald, Stephen, Chileshe, Chinga, Ramus, Camilla, Clements, Christopher, Barrett, Liam, Rockall, Oliver, Geetala, Rahul, Islam, Saif Ul, Nasar, Ahmad, Almond, Kieran, Hassan, Ladan Fatima Yusuf, Shah, Sohan, Brand, Robert Bruce, Yawar, Bakhat, Gilmore, Catherine, McAuley, Daryl, Khan, Waleed, Subramanian, Padmanabhan, Ahluwalia, Aashish, Ozbek, Leyla, Awasthi, Prashant, Sheikh, Hassaan, Barkley, Sarah, Ardolino, Toni, Denning, Alexander, Thiruchandran, Gaj, Fraig, Hossam, Salim, Omar, Iqbal, Rabia, Guy, Stephen, Hogg, Jack, Bagshaw, Oliver, Asmar, Samir, Mitchell, Stephen, Quek, Fang, Fletcher, James, French, Jonathan, Graham, Selina, Sloper, Philip, Sadique, Hammad, Matera, Valentina, Sohail, Zain, Leong, Justin Wei, Issa, Fares, Greasley, Lauren, Marsden, Samuel, Parry, Lucy, Mannan, Syed, Zaheen, Humayoon, Moriarty, Peter, Manning, William, Morris, Timothy, Brockbanks, Carole, Ward, Peter, Pearce, Kim, McMenemy, Louise, Mahmoud, Mohamed, Kieffer, Will, Lal, Aayush, Collis, Justin, Chandrasekaran, Karthik, Foxall-Smith, Michael, Raad, Marjan, Kempshall, Peter, Cheuk, Jocelyn, Leckey, Sam, Gupta, Rishav, Engelke, Daniel, Kemp, Mark, Venkatesan, Aakaash, Hussain, Adnan, Simons, Michiel, Raghavendra, Ram Mohan, Rohra, Satish, Deo, Sunny, Vasarhelyi, Ferenc, Thelwall, Claire, Cullen, Krista, Al-Obaidi, Bilal, Fell, Adam, Thaumeen, Ahmad, Dadabhoy, Maria, Ali, Mira, Ijaz, Sameer, Lin, David, Khan, Basharat, Alsonbaty, Mohamed, Lebe, Moritz, Millan, Ravi Kant, Imam, Sam, Theobald, Emma, Cormack, Jonathan, Sharoff, Lokesh, Eаrdley, Will, Jeyapalan, Rathan, Alcock, Liam, Clayton, Julia, Bates, Natalie, Mahmoud, Yousif, Osborne, Alex, Ralhan, Shvaita, Carpenter, Catriona, Ahmad, Mahmood, Ravi, Sanjeev Musuvathy, Konbaz, Tarek, Lloyd, Thomas, Sheikh, Nomaan, Swealem, Ahmed, Soroya, Emma, Rayan, Faizal, Ward, Thomas, Vasireddy, Aswinkumar, Clarke, Ellisiv, Sikdar, Oishi, Smart, Yat Wing, Windley, Joseph, Ilagan, Belen, Brophy, Edel, Joseph, Sarah, Lowery, Kathryn, Jamjoom, Ammer, Ismayl, Ghiath, Aujla, Randeep, Sambhwani, Sharan, Ramasamy, Arul, Khalaf, Ahmed, Ponugoti, Nikhil, Teng, Wai Huang, Masud, Saqib, Otoibhili, Eghe, Clarkson, Martin, Nafea, Mohamed, Sarhan, Mohamed, Hanna, Shady, Kelly, Andrew, Curtis, Alex, Gourbault, Lysander, Tarhini, Mariam, Platt, Nicholas, Fleming, Thomas, Pemmaraju, Gopalakrishna, Choudri, Mohammed Junaid, Burahee, Abdus, Hassan, Labiba, Hamid, Laveeza, Loveday, David, Edres, Kareem, Schankat, Kerstin, Granger, Luke, Goodbun, Matthew, Parikh, Sunny, Johnson-Lynn, Sarah, Griffiths, Alexandra, Rai, Avinash, Chandler, Henry, Guiot, Luke, Appleyard, Thomas, Robinson, Karen, Fong, Angus, Watts, Anna, Stedman, Tobias, Walton, Victoria, Inman, Dominic, Liaw, Frank, Hadfield, James, McGovern, Julia, Baldock, Thomas, White, Jonathan, Seah, Matthew, Jacob, Neville, Ali, Zaid Haj, Goff, Thomas, Sanalla, Ahmed, Gomati, Ayoub, Nordin, Louise, Hassan, Eslam, Ramadan, Omar, Teoh, Kar Hao, Baskaran, Dinnish, Ngwayi, James, Abbakr, Lina, Blackmore, Noah, Mansukhani, Sameer, Guryel, Enis, Harper, Adam, Cashman, Emily, Brooker, Joanne, Pack, Louise, Regan, Nora, Wagner, Wilhelm, Selim, Amr, Archer, Debbie, McConaghie, Gregory, Patel, Ravi, Gibson, William, Pasapula, Chandra S, Youssef, Hesham, Aziz, Md Abdul, Subhash, Sadhin, Banaszkiewicz, Paul, Elzawahry, Ahmed, Neo, Chryssa, Wei, Nicholas, Bhaskaran, Arun, Sharma, Abhishek, Factor, Danielle, Shahin, Fatma, Shields, David, Ferreira, Catarina Dores Fernandes, Jeyakumar, Gowsikan, Liao, Quintin, Sinnerton, Robert, Ashwood, Neil, Sarhan, Islam, Ker, Andrew, Phelan, Sean, Paxton, James, McAuley, Joseph, Moulton, Lawrence, Mohamed, Ahmed, Dias, Ana, Ho, Beatrice, Francis, Daniel, Miller, Sarah, Phillips, Jon, Jones, Robin, Arthur, Calum, Oag, Erlend, Thutoetsile, Kamogelo, Bell, Katrina, Milne, Kirsty, Whitefield, Reiss, Patel, Kuntal, Singh, Abhimanyu, Morris, Geraint, Parkinson, Dawn, Patil, Amogh, Hamid, Hassan, Syam, Kevin, Singh, Rohit, Menon, Deepak, Crooks, Sophie, Borland, Steven, Rohman, Adam, Nicholson, Alys, Smith, Ben, Hafiz, Nauman, Kolhe, Shivam, Waites, Matthew, Piper, Dani, Westacott, David, Grimshaw, Jessica, Bott, Alasdair, Berry, Alexander, Battle, Joseph, Flannery, Oliver, Iyengar, Karthikeyan P, Thakur, Abdul Wadood, Yousef, Mina, Bansod, Vaibhav, El-nahas, Walaa, Dawe, Edward, Oladeji, Emmanuel, Federer, Simon, Trompeter, Alex, Pritchard, Anna, Shurovi, Badrun, Jordan, Chris, Little, Max, Sivaloganathan, Sivanshankar, Shaunak, Shalin, Watters, Hazel, Luck, Joshua, Zbaeda, Mohamed, Frasquet-Garcia, Antonio, Warner, Christian, Telford, Jeremy, Rooney, Joanna, Attwood, Joseph, Wilson, Faye, Panagiotopoulos, Andreas, Keane, Conal, Scott, Helen, Mazel, Rebecca, Maggs, Joanna, Skinner, Edward, McMunn, Finlay, Lau, Joshua, Ravikumar, Kasetti, Thakker, Dev, Gill, Moneet, McCarthy, Phillip, Fossey, Gavin, Shah, Sohaib, McAlinden, Gavan, McGoldrick, Peter, O'Brien, Scarlett, Patil, Sunit, Millington, Antonia, Umar, Hamza, Sehdev, Simran, Dyer-Hill, Thomas, Yu Kwan, Tsun, Tanagho, Andy, Hagnasir, Ahmed, White, Thomas, Bano, Christopher, Kissin, Eleanor, Ghani, Rafia, Thomas, Philip S W, McMullan, Mark, Walmsley, Matthew, Elgendy, Mohamed, Winstanley, Robert, Round, Joanne, Baxter, Mark, Thompson, Emett, Hogan, Kathryn, Youssef, Khaled, Fetouh, Sherif, Hopper, Graeme P, Simpson, Cameron, Warren, Craig, Waugh, Dominic, Nair, Gopikrishnan, Ballantyne, Andy, Blacklock, Calum, O'Connell, Ciara, Toland, Gemma, McIntyre, Joshua, Ross, Lauren, Badge, Ravindra, Loganathan, Deeraj, Turner, Ian, Ball, Matthew, Maqsood, Saad, Deierl, Krisztian, Beer, Alexander, Tan, Arthur Chen Wun, Mackinnon, Thomas, Gade, Venkat, Gill, James, Yu San, Kay, Archunan, Maheswaran Warren, Shaikh, Mariyam, Ugbah, Onyinye, Uwaoma, Sade, Pillai, Anand, Nath, Upamanyu, Rohan, Farhan-Alanie, M.M., Chinweze, R., Walker, R., and Eardley, W.G.P.

Published
2024
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13. Prevalence of Bacterial Codetection and Outcomes for Infants Intubated for Respiratory Infections

Author

Karsies, Todd, Shein, Steven L., Diaz, Franco, Vasquez-Hoyos, Pablo, Alexander, Robin, Pon, Steven, González-Dambrauskas, Sebastián, Yock-Corrales, Adriana, Rotta, Alex, Prout, Andrew, Wen, Andrew, Camporesi, Anna, Vargas, Arieth Figueroa, Coates, Bria, Piñeres-Olave, Byron Enrique, Stulce, Casey, Watson, Christopher, Francoeur, Conall, Cantillano, Edwin Mauricio, Zemanete, Eliana, Castro, Francisca, Yague, Gema Perez, Ozdemir, Goktug, Chandnani, Harsha, Harwayne-Gidansky, Ilana, Cinquegrani, Karina, Izquierdo, Ledys, Polikoff, Lee, Valero, Leonardo, Gaspers, Mary, Maamari, Mia, Kangin, Murat, Rodriguez, Nils Casson, Ozturk, Nilufer, Castellani, Pablo, Khandhar, Paras, Jabornisky, Roberto, Arana, Rosa, Pardo, Rosalba, Palomino, Rubén Lasso, Nofziger, Ryan, Torales, Santiago Ayala, Ambati, Shashikanth, Gertz, Shira, Jeyapalan, Simi, Murthy, Srinivas, Muisyo, Teddy, Lillitwat, Weerapong, and Lopez-Alarcon, Yurika

Published
2024
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17. Immune infiltration, aggressive pathology, and poor survival outcomes in RECQL helicase deficient breast cancers

Author

Ayat Lashen, Abdulbaqi Al-Kawaz, Jennie N Jeyapalan, Shatha Alqahtani, Ahmed Shoqafi, Mashael Algethami, Michael Toss, Andrew R Green, Nigel P Mongan, Sudha Sharma, Mohammad R Akbari, Emad A Rakha, and Srinivasan Madhusudan

Subjects
RECQL, CD8, FOXP3, IL17, PDL1, PD1, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

RECQL is essential for genomic stability. Here, we evaluated RECQL in 449 pure ductal carcinomas in situ (DCIS), 152 DCIS components of mixed DCIS/invasive breast cancer (IBC) tumors, 157 IBC components of mixed DCIS/IBC and 50 normal epithelial terminal ductal lobular units (TDLUs). In 726 IBCs, CD8+, FOXP3+, IL17+, PDL1+, PD1+ T-cell infiltration (TILs) were investigated in RECQL deficient and proficient cancers. Tumor mutation burden (TMB) was evaluated in five RECQL germ-line mutation carriers with IBC by genome sequencing. Compared with normal epithelial cells, a striking reduction in nuclear RECQL in DCIS was evident with aggressive pathology and poor survival. In RECQL deficient IBCs, CD8+, FOXP3+, IL17+ or PDL1+ TILs were linked with aggressive pathology and shorter survival. In germline RECQL mutation carriers, increased TMB was observed in 4/5 tumors. We conclude that RECQL loss is an early event in breast cancer and promote immune cell infiltration.

Published
2024
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21. Investigating mitochondrial trafficking with dopaminergic neurons of the nigrostriatal pathway

Author

Jeyapalan, Nishani

Subjects
616.8
Abstract

Parkinson's disease (PD) is an age-related neurodegenerative disorder affecting more than 1% of the population aged over 60 years of age. PD is characterised by the loss of dopaminergic (DAergic) neurons from the substantia nigra pars compacta (SNpc), with mitochondrial dysfunction believed to be a contributor to this degeneration. The finding that complex I deficits can trigger Parkinsonism in the 1980s, has resulted in growing evidence of mitochondrial impairment in PD and ageing. Alongside the finding that SNpc neurons exhibit increased mtDNA deletion levels, these data suggest mitochondrial defects render them highly vulnerable in PD. These large scale mtDNA deletions have also been associated with the DAergic neuronal loss seen in normal ageing. Mitochondria are dynamic organelles, whose distribution is regulated by organelle transport to balance the energy needs of neurons. Axonal mitochondria travel long and short distances and genetic mutations in the machinery which controls these movements have been identified in early onset PD. Fundamental insight into the mitochondrial transport system has arisen from yeast and fly models, the effects however of altered mitochondrial movement on neuronal function still remain unanswered with a mammalian PD model. Hence, this study investigated mitochondrial trafficking within neurons via two disease models. The first involved the optimisation of a method to observe the movements of fluorescently tagged mitochondria within DAergic neurons in ex vivo nigrostriatal brain slices. Young and old mice were studied to understand the effects of age on these movements. Changes in these movements in the presence of PD pathology were studied in human wild type alpha-synuclein expressing mice. The second study utilised induced pluripotent stem cells (IPSCs) to compare modifications in mitochondrial trafficking in SNpc neurons from IPSCs derived from a mitochondrial disease patient harbouring a large scale mtDNA deletion. Mitochondrial movement was first observed within low and high mtDNA deletion cell lines, to ascertain the effect of mitochondrial dysfunction on the movement of these organelles. Following this initial study, the effect of mitochondrial Ca2+ extrusion into the cytoplasm was investigated, alongside how this mediated mitochondrial motility. This study successfully managed to obtain videos of mitochondrial motility, from cell body to synapse, allowing the observation of speed, directionality and membrane potential of mitochondria within neurons of these disease models. These models have collectively provided information on the movements and trafficking of mitochondria in both culture and in a mouse model, presenting a promising method to comprehend the consequences of mitochondrial dysfunction in PD.

Published
2020

22. Gender and authorship of publications from Pediatric Acute Lung Injury and Sepsis Investigators (PALISI)

Author

Asumthia S. Jeyapalan, Stephanie R. Brown, Mary G. Gaspers, Brittany Haliani, Sapna R. Kudchadkar, Courtney M. Rowan, and Shira J. Gertz

Subjects
diversity, equity, inclusion, critical care, pediatrics, authorship, Pediatrics, RJ1-570
Abstract

IntroductionPediatric Acute Lung Injury and Sepsis Investigators (PALISI) is a network fostering clinical research to optimize care for critically ill children. We aim to examine the efforts of the PALISI Network to increase gender parity in research, as evidenced by authorship.MethodsThe first and senior authors of all published PALISI articles from 2002 to 2021 were analyzed for gender of presentation. Funding sources, impact factors, professional roles, and location were extracted.ResultsWe identified 303 articles, 61 published from 2002 to 2011, and 242 from 2012 to 2021. There were 302 first authors, representing 188 unique individuals, and 283 senior authors, representing 119 unique individuals. Over half (55.6%, n = 168) of the first authors were women. More women were first authors from 2012 to 2021 (n = 145, 60.2%) as compared to the years 2002–2011 [37.7%, n = 23, OR = 2.50 (95% CI: 1.40, 4.45, p = 0.002)]. Senior authors were 36.0% (n = 102) women, with no change over time. Women senior authors had a higher proportion of women first authors (67.7% vs. 32.4%, p = 0.017). No gender differences were noted based on article type or impact factor. The majority of authors came from institutions in the United States. Women had comparatively more NIH and CDC funding but received less funding from foundations and AHRQ.DiscussionIn PALISI publications, first authorship by women has increased over time, such that it now exceeds both the proportion of women pediatric intensivists and women first authors in critical care publications. Senior authorship by women has been stagnant. A multifactorial approach by individuals, institutions, networks, and journals is needed to bring senior women authors to parity.

Published
2023
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23. Unravelling the clinicopathological and functional significance of replication protein A (RPA) heterotrimeric complex in breast cancers

Author

Mashael Algethami, Michael S. Toss, Corinne L. Woodcock, Chandar Jaipal, Juliette Brownlie, Ahmed Shoqafi, Adel Alblihy, Katia A. Mesquita, Andrew R. Green, Nigel P. Mongan, Jennie N. Jeyapalan, Emad A. Rakha, and Srinivasan Madhusudan

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Replication Protein A (RPA), a heterotrimeric complex consisting of RPA1, 2, and 3 subunits, is a single-stranded DNA (ssDNA)-binding protein that is critically involved in replication, checkpoint regulation and DNA repair. Here we have evaluated RPA in 776 pure ductal carcinomas in situ (DCIS), 239 DCIS that co-exist with invasive breast cancer (IBC), 50 normal breast tissue and 4221 IBC. Transcriptomic [METABRIC cohort (n = 1980)] and genomic [TCGA cohort (n = 1090)] evaluations were completed. Preclinically, RPA deficient cells were tested for cisplatin sensitivity and Olaparib induced synthetic lethality. Low RPA linked to aggressive DCIS, aggressive IBC, and shorter survival outcomes. At the transcriptomic level, low RPA tumours overexpress pseudogene/lncRNA as well as genes involved in chemical carcinogenesis, and drug metabolism. Low RPA remains linked with poor outcome. RPA deficient cells are sensitive to cisplatin and Olaparib induced synthetic lethality. We conclude that RPA directed precision oncology strategy is feasible in breast cancers.

Published
2023
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26. Towards Personalized Management of Ovarian Cancer

Author

Algethami M, Kulkarni S, Sadiq MT, Tang HKC, Brownlie J, Jeyapalan JN, Mongan NP, Rakha EA, and Madhusudan S

Subjects
ovarian cancer, poly-(adp)-ribose polymerase (parp), synthetic lethality, platinum chemotherapy., Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Mashael Algethami,1 Sanat Kulkarni,2 Maaz T Sadiq,3 Hiu KC Tang,4 Juliette Brownlie,1 Jennie N Jeyapalan,1 Nigel P Mongan,1 Emad A Rakha,1 Srinivasan Madhusudan1,4 1Nottingham Biodiscovery Institute, School of Medicine, University of Nottingham, University Park, Nottingham, NG7 3RD, UK; 2Department of Medicine, City Hospital, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, B18 7QH, UK; 3Cancer Centre, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Trust, Birmingham, B15 2GW, UK; 4Department of Oncology, Nottingham University Hospitals, Nottingham, NG51PB, UKCorrespondence: Srinivasan Madhusudan, Nottingham Biodiscovery Institute, School of Medicine, University Park, University of Nottingham, Nottingham, NG7 3RD, UK, Tel +44(0)115 823 1850, Fax +44(0)115 823 1849, Email srinivasan.madhusudan@nottingham.ac.ukAbstract: Despite advances in surgery and chemotherapy, the overall outcomes for patients with advanced ovarian cancer remain poor. Although initial response rates to platinum-based chemotherapy is about 60– 80%, most patients will have recurrence and succumb to the disease. However, a DNA repair–directed precision medicine strategy has recently generated real hope in improving survival. The clinical development of PARP inhibitors has transformed lives for many patients with BRCA germline-deficient and/or platinum-sensitive epithelial ovarian cancers. Antiangiogenic agents and intraperitoneal chemotherapy approaches may also improve outcomes in patients. Moreover, evolving immunotherapeutic opportunities could also positively impact patient outcomes. Here we review the current clinical state of PARP inhibitors and other clinically viable targeted approaches in ovarian cancer.Keywords: ovarian cancer, poly-(ADP)-ribose polymerase, PARP, synthetic lethality, platinum chemotherapy

Published
2022

29. ASEPTIC: primary antibiotic prophylaxis using co-trimoxazole to prevent SpontanEous bacterial PeritoniTIs in Cirrhosis—study protocol for an interventional randomised controlled trial

Author

Dominic Crocombe, Norin Ahmed, Indran Balakrishnan, Ekaterina Bordea, Marisa Chau, Louise China, Lynsey Corless, Victoria Danquah, Hakim-Moulay Dehbi, John F. Dillon, Ewan H. Forrest, Nick Freemantle, David Peter Gear, Coral Hollywood, Rachael Hunter, Tasheeka Jeyapalan, Yiannis Kallis, Stuart McPherson, Iulia Munteanu, Jim Portal, Paul Richardson, Stephen D. Ryder, Amandeep Virk, Gavin Wright, and Alastair O’Brien

Subjects
Liver cirrhosis, Ascites, Co-trimoxazole, Infection, Spontaneous bacterial peritonitis, Antimicrobial resistance, Medicine (General), R5-920
Abstract

Abstract Background Bacterial infection is a major cause of mortality in patients with cirrhosis. Spontaneous bacterial peritonitis (SBP) is a serious and common infection in patients with cirrhosis and ascites. Secondary prophylactic antibiotic therapy has been shown to improve outcomes after an episode of SBP but primary prophylaxis to prevent the first episode of SBP remains contentious. The aim of this trial is to assess whether primary antibiotic prophylaxis with co-trimoxazole improves overall survival compared to placebo in adults with cirrhosis and ascites. Methods The ASEPTIC trial is a multicentre, placebo-controlled, double-blinded, randomised controlled trial (RCT) in England, Scotland, and Wales. Patients aged 18 years and older with cirrhosis and ascites requiring diuretic treatment or paracentesis, and no current or previous episodes of SBP, are eligible, subject to exclusion criteria. The trial aims to recruit 432 patients from at least 30 sites. Patients will be randomised in a 1:1 ratio to receive either oral co-trimoxazole 960 mg or an identical placebo once daily for 18 months, with 6 monthly follow-up visits thereafter (with a maximum possible follow-up period of 48 months, and a minimum of 18 months). The primary outcome is overall survival. Secondary outcomes include the time to the first incidence of SBP, hospital admission rates, incidence of other infections (including Clostridium difficile) and antimicrobial resistance, patients’ health-related quality of life, health and social care resource use, incidence of cirrhosis-related decompensation events, liver transplantation, and treatment-related serious adverse events. Discussion This trial will investigate the efficacy, safety, and cost-effectiveness of co-trimoxazole for patients with liver cirrhosis and ascites to determine whether this strategy improves clinical outcomes. Given there are no treatments that improve survival in decompensated cirrhosis outside of liver transplant, if the trial has a positive outcome, we anticipate widespread adoption of primary antibiotic prophylaxis. Trial registration ClinicalTrials.gov NCT043955365 . Registered on 18 April 2020. Research ethical approval was granted by the Research Ethics Committee (South Central – Oxford B; REC 19/SC/0311) and the Medicines and Healthcare products Regulatory Agency (MHRA).

Published
2022
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30. Targeting Mre11 overcomes platinum resistance and induces synthetic lethality in XRCC1 deficient epithelial ovarian cancers

Author

Adel Alblihy, Reem Ali, Mashael Algethami, Ahmed Shoqafi, Michael S. Toss, Juliette Brownlie, Natalie J. Tatum, Ian Hickson, Paloma Ordonez Moran, Anna Grabowska, Jennie N. Jeyapalan, Nigel P. Mongan, Emad A. Rakha, and Srinivasan Madhusudan

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Platinum resistance is a clinical challenge in ovarian cancer. Platinating agents induce DNA damage which activate Mre11 nuclease directed DNA damage signalling and response (DDR). Upregulation of DDR may promote chemotherapy resistance. Here we have comprehensively evaluated Mre11 in epithelial ovarian cancers. In clinical cohort that received platinum- based chemotherapy (n = 331), Mre11 protein overexpression was associated with aggressive phenotype and poor progression free survival (PFS) (p = 0.002). In the ovarian cancer genome atlas (TCGA) cohort (n = 498), Mre11 gene amplification was observed in a subset of serous tumours (5%) which correlated highly with Mre11 mRNA levels (p

Published
2022
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31. IMPACT-Global Hip Fracture Audit: Nosocomial infection, risk prediction and prognostication, minimum reporting standards and global collaborative audit: Lessons from an international multicentre study of 7,090 patients conducted in 14 nations during the COVID-19 pandemic

Author

Abdul-Jabar, Hani, Abu-Rajab, Rashid, Abugarja, Ahmed, Adam, Karen, Aguado Hernández, Héctor J., Améstica Lazcano, Gedeón, Anderson, Sarah, Ansar, Mahmood, Antrobus, Jonathan, Aragón Achig, Esteban Javier, Archunan, Maheswaran, Arrieta Salinas, Mirentxu, Ashford–Wilson, Sarah, Assens Gibert, Cristina, Athanasopoulou, Katerina, Awadelkarim, Mohamed, Baird, Stuart, Bajada, Stefan, Balakrishnan, Shobana, Balasubramanian, Sathishkumar, Ballantyne, James A., Bárcena Goitiandia, Leopoldo, Barkham, Benjamin, Barmpagianni, Christina, Barres-Carsi, Mariano, Barrett, Sarah, Baskaran, Dinnish, Bell, Jean, Bell, Katrina, Bell, Stuart, Bellelli, Giuseppe, Benchimol, Javier Alberto, Boietti, Bruno Rafael, Boswell, Sally, Braile, Adriano, Brennan, Caitlin, Brent, Louise, Brooke, Ben, Bruno, Gaetano, Burahee, Abdus, Burns, Shirley, Calabrò, Giampiero, Campbell, Lucy, Carabelli, Guido Sebastian, Carnegie, Carol, Carretero Cristobal, Guillermo, Caruana, Ethan, Cassinello Ogea, M.a Concepción, Castellanos Robles, Juan, Castillon, Pablo, Chakrabarti, Anil, Cecere, Antonio Benedetto, Chen, Ping, Clarke, Jon V., Collins, Grace, Corrales Cardenal, Jorge E., Corsi, Maurizio, Cózar Adelantado, Gara María, Craxford, Simon, Crooks, Melissa, Cuarental-García, Javier, Cuthbert, Rory, Dall, Graham, Daskalakis, Ioannis, De Cicco, Annalisa, de la Fuente de Dios, Diana, Demaria, Pablo, Dereix, John, Díaz Jiménez, Julian, Dinamarca Montecinos, José Luis, Do Le, Ha Phuong, Donoso Coppa, Juan Pablo, Drosos, Georgios, Duffy, Andrew, East, Jamie, Eastwood, Deborah, Elbahari, Hassan, Elias de Molins Peña, Carmen, Elmamoun, Mamoun, Emmerson, Ben, Escobar Sánchez, Daniel, Faimali, Martina, Farré-Mercadé, Maria Victòria, Farrow, Luke, Fayez, Almari, Fell, Adam, Fenner, Christopher, Ferguson, David, Finlayson, Louise, Flores Gómez, Aldo, Freeman, Nicholas, French, Jonathan, Gabardo Calvo, Santiago, Gagliardo, Nicola, Garcia Albiñana, Joan, García Cruz, Guillermo, García de Cortázar Antolín, Unai, García Virto, Virginia, Gealy, Sophie, Gil Caballero, Sandra Marcela, Gill, Moneet, González González, María Soledad, Gopireddy, Rajesh, Guntley, Diane, Gurung, Binay, Guzmán Rosales, Guadalupe, Haddad, Nedaa, Hafeez, Mahum, Haller, Petra, Halligan, Emer, Hardie, John, Hawker, Imogen, Helal, Amr, Herrera Cruz, Mariana, Herreros Ruiz-Valdepeñas, Ruben, Horton, James, Howells, Sean, Howieson, Alan, Hughes, Luke, Hünicken Torrez, Flavia Lorena, Hurtado Ortega, Ana, Huxley, Peter, Hamid, Hytham K.S., Ilahi, Nida, Iliadis, Alexis, Inman, Dominic, Jadhao, Piyush, Jandoo, Rajan, Jawad, Lucy, Jayatilaka, Malwattage Lara Tania, Jenkins, Paul J., Jeyapalan, Rathan, Johnson, David, Johnston, Andrew, Joseph, Sarah, Kapoor, Siddhant, Karagiannidis, Georgios, Karanam, Krishna Saga, Kattakayam, Freddy, Konarski, Alastair, Kontakis, Georgios, Labrador Hernández, Gregorio, Lancaster, Victoria, Landi, Giovanni, Le, Brian, Liew, Ignatius, Logishetty, Kartik, Lopez Marquez, Andrew Carlomaria Daniel, Lopez, Judit, Lum, Joann, Macpherson, Gavin J., Madan, Suvira, Mahroof, Sabreena, Malik-Tabassum, Khalid, Mallina, Ravi, Maqsood, Afnan, Marson, Ben, Martin Legorburo, M. José, Martin-Perez, Encarna, Martínez Jiménez, Tania, Martinez Martin, Javier, Mayne, Alistair, Mayor, Amy, McAlinden, Gavan, McLean, Lucille, McDonald, Lorna, McIntyre, Joshua, McKay, Pamela, McKean, Greg, McShane, Heather, Medici, Antonio, Meeke, Chelsea, Meldrum, Evonne, Mendez, Mijail, Mercer, Scott, Merino Perez, Josu, Mesa-Lampré, María-Pilar, Mighton, Shuna, Milne, Kirsty, Mohamed Yaseen, Muhammed, Moppett, Iain, Mora, Jesus, Morales-Zumel, Sira, Moreno Fenoll, Irene Blanca, Mousa, Adham, Murray, Alastair W., Murray, Elspeth V., Nair, Radhika, Neary, Fiona, Negri, Giacomo, Negus, Oliver, Newham-Harvey, Fiona, Ng, Nigel, Nightingale, Jess, Noor Mohamed Anver, Sumiya, Nunag, Perrico, O'Hare, Matthew, Ollivere, Ben, Ortés Gómez, Raquel, Owens, AnneMarie, Page, Siobhan, Palloni, Valentina, Panagiotopoulos, Andreas, Panagiotopoulos, Elias, Panesar, Paul, Papadopoulos, Antonios, Spyridon, Papagiannis, Pareja Sierra, Teresa, Park, Chang, Parwaiz, Hammad, Paterson-Byrne, Paul, Patton, Sam, Pearce, Jack, Porter, Marina, Pellegrino, Achille, Pèrez Cuellar, Arturo, Pezzella, Raffaele, Phadnis, Ashish, Pinder, Charlotte, Piper, Danielle, Powell-Bowns, Matilda, Prieto Martín, Rocío, Probert, Annabel, Ramesh, Ashwanth, Ramírez de Arellano, Manuel Vicente Mejía, Renton, Duncan, Rickman, Stephen, Robertson, Alastair, Roche Albero, Adrian, Rodrigo Verguizas, José Alberto, Rodríguez Couso, Myriam, Rooney, Joanna, Sáez-López, Pilar, Saldaña-Díaz, Andres, Santulli, Adriano, Sanz Pérez, Marta Isabel, Sarraf, Khaled M., Scarsbrook, Christine, Scott, Chloe E.H., Scott, Jennifer, Shah, Sachi, Sharaf, Sharief, Sharma, Sidharth, Shirley, Denise, Siano, Antonio, Simpson, James, Singh, Abhinav, Singh, Amit, Sinnett, Tim, Sisodia, Gurudatt, Smith, Philomena, Sophena Bert, Eugenia, Steel, Michael, Stewart, Avril, Stewart, Claire, Sugand, Kapil, Sullivan, Niall, Sweeting, Lauren, Symes, Michael, Tan, Dylan Jun Hao, Tancredi, Francesco, Tatani, Irini, Thomas, Philip, Thomson, Fraser, Toner, Niamh S., Tong, Anna, Toro, Antonio, Tosounidis, Theodoros, Tottas, Stylianos, Trinidad Leo, Andrea, Tucker, Damien, Vemulapalli, Krishna, Ventura Garces, Diego, Vernon, Olivia Katherine, Viveros Garcia, Juan Carlos, Ward, Alex, Ward, Kirsty, Watson, Kate, Weerasuriya, Thisara, Wickramanayake, Udara, Wilkinson, Hannah, Windley, Joseph, Wood, Janet, Wynell-Mayow, William, Zatti, Giovanni, Zeiton, Moez, Zurrón Lobato, Miriam, Hall, Andrew J., Clement, Nicholas D., Ojeda-Thies, Cristina, MacLullich, Alasdair MJ., Toro, Giuseppe, Johansen, Antony, White, Tim O., and Duckworth, Andrew D.

Published
2022
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32. Noninvasive Ventilation for Pediatric Acute Respiratory Distress Syndrome: Experience From the 2016/2017 Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology Prospective Cohort Study*

Author

Emeriaud, Guillaume, Pons-Òdena, Marti, Bhalla, Anoopindar K., Shein, Steven L., Killien, Elizabeth Y., Modesto i Alapont, Vicent, Rowan, Courtney, Baudin, Florent, Lin, John C., Grégoire, Gabrielle, Napolitano, Natalie, Mayordomo-Colunga, Juan, Diaz, Franco, Cruces, Pablo, Medina, Alberto, Smith, Lincoln, Khemani, Robinder G., Sforza, Jesica, Poterala, Rossana, Fernandez, Analia, Avila Vera, Antonio, Orqueda, Daniel, Agueda Vidal, Nilda, Rosemary, Deheza, Turon, Gonzalo, Monjes, Cecilia, Espanol, Segundo Fernando, Serrate, Alejandro Siaba, Iolster, Thomas, Torres, Silvio, Cinquegrani, Karina, Jose Montes, Maria, Capocasa, Patricia, Ferreyra, Marcela, Castellani, Pablo, Giampieri, Martin, Pedraza, Claudia, Landry, Luis Martin, Althabe, Maria, Fortini, Yanina Vanesa, Botta, Priscila, Paziencia, Fernando, Erickson, Simon, Barr, Samantha, Shea, Sara, Butt, Warwick, Delzoppo, Carmel, Pintimalla, Alyssa, Leon, Alejandro Fabio Martinez, Rivera, Gustavo Alfredo Guzman, Jouvet, Philippe, Emeriaud, Guillaume, Dumitrascu, Mariana, Ellen French, Mary, Caro I, Daniel, Castillo, Andres E., Romero, Pablo Cruces, Medina, Tania, Madrid, Paula Pavez, Cortez, Ambar, Alvear, Jimena, Acuna, Carlos, Diaz, Franco, Nunez, Maria Jose, Araya, Adriana Wegner, Mundaca, Loreto Godoy, Chen, Yang, Lozano, German Perez, Carrero, Rosalba Pardo, Alarcon, Yurika Paola Lopez, Vega, Liliana Mazzillo, Izquierdo, Ledys Maria, Olave, Byron Enrique Piñeres, Orrego, Cesar Zuluaga, Lopez, Deyanira Quinonez, Hoyos, Pablo Vasquez, Vavrina, Martin, Zurek, Jiri, Campos-Miño, Santiago, Yerovi, Rocio, Bridier, Armelle, Payen, Valerie, Milesi, Christophe, Bourgoin, Pierre, Travert, Brendan, Genuini, Mathieu, Starck, Julie, Maria, Matthieu, Guichoux, Julie, Baudin, Florent, Briassoulis, George, Ilia, Stavroula, Di Nardo, Matteo, Camporesi, Anna, Chiusolo, Fabrizio, Shime, Nobuaki, Ohshimo, Shinichiro, Kida, Yoshiko, Kyo, Michihito, Tabata, Yuichi, Tang, Swee Fong, Tai, Chian Wern, Lum, Lucy Chai See, Elghuwael, Ismail, Rivera, Nestor Javier Jimenez, Jarillo Quijada, Alberto E, Kneyber, Martin, Dijkstra, Sandra, Beca, John, Sherring, Claire, Rea, Miriam, Vargas G, Sonia I, Miranda, Daniel Vasquez, Cortez, Grimaldo Ramirez, Tantalean, Jose, Pagowska-Klimek, Izabela, Escobar, Carlos Gil, Moniz, Marta Sousa, Camilo, Cristina, Hazwani, Tarek, Aldairi, Nedaa, Al Amoudi, Ahmed, Alahmadti, Ahmad, Taylor, Ryan, Mendizabal, Mikel, Orayen, Concepcion Goni, Fernandez, Yolanda Lopez, Valle, Juan Ramon, Martinez, Lidia, Orive, Javier Pilar, Brezmes, Marta, Lopez-Herce, Jesus, Parrilla, Julio, Gaboli, Mirella, Gomez, Jose Manuel Gonzalez, Morales Martinez, Antonio, Alapont, Vicent Modesto I, Diaz, Juan Ignacio Sanchez, Llorente de la Fuente, Ana M., Palanca Arias, Daniel, Madurga Revilla, Paula, Martinez de Azagra, Amelia, Garcia Gonzalez, Maria, Arjona Villanueva, David, Garcia Casas, Paula, Brio Sanagustin, Sonia, Pons Odena, Marti, Medina, Alberto, Onate Vergara, Eider, Rodriguez Campoy, Patricia, Reyes Dominguez, Susana, Dursun, Oguz, Atike Ongun, Ebru, Kamit Can, Fulya, Berna Anil, Ayse, Baines, Paul, Walsh, Laura, Jones, Dawn, Sadasivam, Kalaimaran, Mildner, Reinout, Plunkett, Adrian, Lillie, Jon, Tibby, Shane, Wellman, Paul, Belfield, Holly, Brierley, Joe, Dominguez, Troy E., Abaleke, Eugenia, Feinstein, Yael, Deep, Akash, Sundararajan, Santosh, Oruganti, Siva, Silvestre, Catarina, Weitz, James, Sheward, Victoria, Macrae, Duncan, Aramburo, Angela, Fortune, Peter-Marc, Subramanian, Gayathri, Jennings, Claire, Dwarakanathan, Buvana, Inwald, David, Feather, Calandra, Agbeko, Rachel, Lawton-Woodhall, Angela, McIntyre, Karen, Sykes, Kim, Pappachan, Jon, Gale, Helen, Mellish, Christie, McCorkell, Jenni, Torero, Luis, Nofziger, Ryan, Latifi, Samir, Anthony, Heather, Sanders, Ron, Hefley, Glenda, Virk, Manpreet, Jaimon, Nancy, Maddux, Aline B., Mourani, Peter M., Ralston, Kimberly, Sierra, Yamila, Khemani, Robinder, Newth, Christopher, Bhalla, Anoopindar, Kwok, Jeni, Morzov, Rica, Mahapatra, Sidharth, Truemper, Edward, Kustka, Lucinda, Nett, Sholeen T., Singleton, Marcy, Dean Jarvis, J., Yehya, Nadir, Napolitano, Natalie, Murphy, Marie, Ronan, Laurie, Morgan, Ryan, Kubis, Sherri, Broden, Elizabeth, Willson, Douglas, Henderson, Grace, Gedeit, Rainer, Murkowski, Kathy, Woods, Katherine, Kasch, Mary, Han, Yong Y, Affolter, Jeremy T, Tieves, Kelly S, Hughes-Schalk, Amber, Chima, Ranjit S., Krallman, Kelli, Stoneman, Erin, Benken, Laura, Yunger, Toni, Schneider, James, Sweberg, Todd, Kessel, Aaron, Carroll, Christopher L., Santanelli, James, Ackerman, Kate G, Cullimore, Melissa, Rowan, Courtney, Bales, Melissa, Keith Dockery, W., Jafari-Namin, Shirin, Barry, Dana, Jane’t, Keary, Alibrahim, Omar, Patankar, Nikhil, Qiao, Haiping, Gertz, Shira, Su, Felice, Haileselassie, Bereketeab, Song, Hanqiu, Bysani, Kris, Monjure, Tracey, Beltramo, Fernando, Totapally, Balagangadhar, Govantes, Beatriz, Coates, Bria, Wellisch, Lawren, Allen, Kiona, Shukla, Avani, Thomas, Neal J., Spear, Debbie, Shein, Steven L., Gertz, Shira, Parker, Margaret M., Sloniewsky, Daniel, Allen, Christine, Harrell, Amy, Pinto, Neethi, Kniola, Allison, Rodgers, Chiara, Cvijanovich, Natalie, Typpo, Katri, Kelley, Connor, King, Caroline, Sapru, Anil, Ratiu, Anna, Ashtari, Neda, Sikora, Lindsay, Jeyapalan, Asumthia S., Coronado-Munoz, Alvaro, Flori, Heidi, Dahmer, Mary K., Jayachandran, Chaandini, Hume, Janet, Nerheim, Dan, Smith, Rebecca, Spaeder, Michael, Adu-Darko, Michelle, Smith, Lincoln, Hartmann, Silvia, Sullivan, Erin, Merritt, Courtney, Al-Subu, Awni, Blom, Andrea, Lin, John C., Spinella, Philip, Hsing, Deyin D., Pon, Steve, Brian Estil, Jim, Gautam, Richa, Giuliano, John S., Jr, and Tala, Joana

Published
2023
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33. The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer

Author

Veronika M. Metzler, Simone de Brot, Daisy B. Haigh, Corinne L. Woodcock, Jennifer Lothion-Roy, Anna E. Harris, Emeli M. Nilsson, Atara Ntekim, Jenny L. Persson, Brian D. Robinson, Francesca Khani, Kristian B. Laursen, Lorraine J. Gudas, Michael S. Toss, Srinivasan Madhusudan, Emad Rakha, David M. Heery, Catrin S. Rutland, Nigel P. Mongan, and Jennie N. Jeyapalan

Subjects
epigenetics, splicing, transcriptional regulation, KDM-inhibitors, histone modification, Biology (General), QH301-705.5
Abstract

Histone H3 lysine 4 (H3K4) methylation is key epigenetic mark associated with active transcription and is a substrate for the KDM1A/LSD1 and KDM5B/JARID1B lysine demethylases. Increased expression of KDM1A and KDM5B is implicated in many cancer types, including prostate cancer (PCa). Both KDM1A and KDM5B interact with AR and promote androgen regulated gene expression. For this reason, there is great interested in the development of new therapies targeting KDM1A and KDM5B, particularly in the context of castrate resistant PCa (CRPC), where conventional androgen deprivation therapies and androgen receptor signalling inhibitors are no longer effective. As there is no curative therapy for CRPC, new approaches are urgently required to suppress androgen signalling that prevent, delay or reverse progression to the castrate resistant state. While the contribution of KDM1A to PCa is well established, the exact contribution of KDM5B to PCa is less well understood. However, there is evidence that KDM5B is implicated in numerous pro-oncogenic mechanisms in many different types of cancer, including the hypoxic response, immune evasion and PI3/AKT signalling. Here we elucidate the individual and cooperative functions of KDM1A and KDM5B in PCa. We show that KDM5B mRNA and protein expression is elevated in localised and advanced PCa. We show that the KDM5 inhibitor, CPI-455, impairs androgen regulated transcription and alternative splicing. Consistent with the established role of KDM1A and KDM5B as AR coregulators, we found that individual pharmacologic inhibition of KDM1A and KDM5 by namoline and CPI-455 respectively, impairs androgen regulated transcription. Notably, combined inhibition of KDM1A and KDM5 downregulates AR expression in CRPC cells. Furthermore, combined KDM1A and KDM5 inhibition impairs PCa cell proliferation and invasion more than individual inhibition of KDM1A and KDM5B. Collectively our study has identified individual and cooperative mechanisms involving KDM1A and KDM5 in androgen signalling in PCa. Our findings support the further development of KDM1A and KDM5B inhibitors to treat advanced PCa. Further work is now required to confirm the therapeutic feasibility of combined inhibition of KDM1A and KDM5B as a novel therapeutic strategy for targeting AR positive CRPC.

Published
2023
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35. Comparative pathology of dog and human prostate cancer

Author

Toby Ryman‐Tubb, Jennifer H. Lothion‐Roy, Veronika M. Metzler, Anna E. Harris, Brian D. Robinson, Albert A. Rizvanov, Jennie N. Jeyapalan, Victoria H. James, Gary England, Catrin S. Rutland, Jenny L. Persson, Lukas Kenner, Mark A. Rubin, Nigel P. Mongan, and Simone deBrot

Subjects
adenocarcinoma, animal model, canine, neuroendocrine, urology, Veterinary medicine, SF600-1100
Abstract

Abstract Though relatively rare in dogs, prostate cancer (PCa) is the most common non‐cutaneous cancer in men. Human and canine prostate glands share many functional, anatomical and physiological features. Due to these similarities, canine PCa has been proposed as a model for PCa in men. PCa is typically androgen‐dependent at diagnosis in men and for this reason, androgen deprivation therapies (ADT) are important treatments for advanced PCa in men. In contrast, there is some evidence that PCa is diagnosed more commonly in castrate dogs, at which point, limited therapeutic options are available. In men, a major limitation of current ADT is that progression to a lethal and incurable form of PCa, termed castrate‐resistant prostate cancer (CRPC), is common. There is, therefore, an urgent need for a better understanding of the mechanism of PCa initiation and progression to CRPC to enable the development of novel therapeutic approaches. This review focuses on the functional, physiological, endocrine and histopathological similarities and differences in the prostate gland of these species. In particular, we focus on common physiological roles for androgen signalling in the prostate of men and dogs, we review the short‐ and longer‐term effects of castration on PCa incidence and progression in the dog and relate how this knowledge may be relevant to understanding the mechanisms of CRPC in men.

Published
2022
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36. Clinical and molecular significance of the RNA m6A methyltransferase complex in prostate cancer

Author

Jennifer Lothion-Roy, Daisy B. Haigh, Anna E. Harris, Veronika M. Metzler, Mansour Alsaleem, Michael S. Toss, Yousif Kariri, Atara Ntekim, Brian D. Robinson, Francesca Khani, Lorraine J. Gudas, Cinzia Allegrucci, Victoria H. James, Srinivasan Madhusudan, Melissa Mather, Richard D. Emes, Nathan Archer, Rupert G. Fray, Emad Rakha, Jennie N. Jeyapalan, Catrin S. Rutland, Nigel P. Mongan, and Corinne L. Woodcock

Subjects
METTL3, METTL14, WTAP, CBLL1, splicing, transcriptome, Genetics, QH426-470
Abstract

N6-methyladenosine (m6A) is the most abundant internal mRNA modification and is dynamically regulated through distinct protein complexes that methylate, demethylate, and/or interpret the m6A modification. These proteins, and the m6A modification, are involved in the regulation of gene expression, RNA stability, splicing and translation. Given its role in these crucial processes, m6A has been implicated in many diseases, including in cancer development and progression. Prostate cancer (PCa) is the most commonly diagnosed non-cutaneous cancer in men and recent studies support a role for m6A in PCa. Despite this, the literature currently lacks an integrated analysis of the expression of key components of the m6A RNA methyltransferase complex, both in PCa patients and in well-established cell line models. For this reason, this study used immunohistochemistry and functional studies to investigate the mechanistic and clinical significance of the METTL3, METTL14, WTAP and CBLL1 components of the m6A methyltransferase complex in PCa specimens and cell lines. Expression of METTL3 and CBLL1, but not METTL14 and WTAP, was associated with poorer PCa patient outcomes. Expression of METTL3, METTL14, WTAP and CBLL1 was higher in PCa cells compared with non-malignant prostate cells, with the highest expression seen in castrate-sensitive, androgen-responsive PCa cells. Moreover, in PCa cell lines, expression of METTL3 and WTAP was found to be androgen-regulated. To investigate the mechanistic role(s) of the m6A methyltransferase complex in PCa cells, short hairpin RNA (shRNA)-mediated knockdown coupled with next generation sequencing was used to determine the transcriptome-wide roles of METTL3, the catalytic subunit of the m6A methyltransferase complex. Functional depletion of METTL3 resulted in upregulation of the androgen receptor (AR), together with 134 AR-regulated genes. METTL3 knockdown also resulted in altered splicing, and enrichment of cell cycle, DNA repair and metabolic pathways. Collectively, this study identified the functional and clinical significance of four essential m6A complex components in PCa patient specimens and cell lines for the first time. Further studies are now warranted to determine the potential therapeutic relevance of METTL3 inhibitors in development to treat leukaemia to benefit patients with PCa.

Published
2023
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38. ASEPTIC: primary antibiotic prophylaxis using co-trimoxazole to prevent SpontanEous bacterial PeritoniTIs in Cirrhosis—study protocol for an interventional randomised controlled trial

Author

Crocombe, Dominic, Ahmed, Norin, Balakrishnan, Indran, Bordea, Ekaterina, Chau, Marisa, China, Louise, Corless, Lynsey, Danquah, Victoria, Dehbi, Hakim-Moulay, Dillon, John F., Forrest, Ewan H., Freemantle, Nick, Gear, David Peter, Hollywood, Coral, Hunter, Rachael, Jeyapalan, Tasheeka, Kallis, Yiannis, McPherson, Stuart, Munteanu, Iulia, Portal, Jim, Richardson, Paul, Ryder, Stephen D., Virk, Amandeep, Wright, Gavin, and O’Brien, Alastair

Published
2022
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39. Multi-institutional study of reirradiation for recurrent high grade glioma.

Author

Helis, Corbin A., primary, Zarabi, Hosniya, additional, Russell, Gregory, additional, LeCompte, Michael, additional, Liu, Weiren, additional, Hattangadi-Gluth, Jona, additional, Halasz, Lia Moriguchi, additional, Soltys, Scott G., additional, Braunstein, Steve E., additional, Wang, Tony J. C., additional, Shi, Wenyin, additional, Shen, Colette, additional, Mignano, John, additional, Masters, Adrianna, additional, Kleinberg, Lawrence, additional, Huang, Jiayi, additional, Hopper, Austin, additional, Barbour, Andrew Buhl, additional, Jeyapalan, Suriya A., additional, and Chan, Michael D, additional

Published
2024
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41. Untangling the clinicopathological significance of MRE11-RAD50-NBS1 complex in sporadic breast cancers

Author

Adel Alblihy, Ahmed Shoqafi, Michael S. Toss, Mashael Algethami, Anna E. Harris, Jennie N. Jeyapalan, Tarek Abdel-Fatah, Juliette Servante, Stephen Y. T. Chan, Andrew Green, Nigel P. Mongan, Emad A. Rakha, and Srinivasan Madhusudan

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract The MRE11–RAD50–NBS1 (MRN) complex is critical for genomic stability. Although germline mutations in MRN may increase breast cancer susceptibility, such mutations are extremely rare. Here, we have conducted a comprehensive clinicopathological study of MRN in sporadic breast cancers. We have protein expression profiled for MRN and a panel of DNA repair factors involved in double-strand break repair (BRCA1, BRCA2, ATM, CHK2, ATR, Chk1, pChk1, RAD51, γH2AX, RPA1, RPA2, DNA-PKcs), RECQ DNA helicases (BLM, WRN, RECQ1, RECQL4, RECQ5), nucleotide excision repair (ERCC1) and base excision repair (SMUG1, APE1, FEN1, PARP1, XRCC1, Pol β) in 1650 clinical breast cancers. The prognostic significance of MRE11, RAD50 and NBS1 transcripts and their microRNA regulators (hsa-miR-494 and hsa-miR-99b) were evaluated in large clinical datasets. Expression of MRN components was analysed in The Cancer Genome Atlas breast cancer cohort. We show that low nuclear MRN is linked to aggressive histopathological phenotypes such as high tumour grade, high mitotic index, oestrogen receptor- and high-risk Nottingham Prognostic Index. In univariate analysis, low nuclear MRE11 and low nuclear RAD50 were associated with poor survival. In multivariate analysis, low nuclear RAD50 remained independently linked with adverse clinical outcomes. Low RAD50 transcripts were also linked with reduced survival. In contrast, overexpression of hsa-miR-494 and hsa-miR-99b microRNAs was associated with poor survival. We observed large-scale genome-wide alterations in MRN-deficient tumours contributing to aggressive behaviour. We conclude that MRN status may be a useful tool to stratify tumours for precision medicine strategies.

Published
2021
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44. Development and application of chiral analytical methods for metabolic profiling

Author

Jeyapalan, Senthuran, Athersuch, Toby, and Nicholson, Jeremy

Subjects
614
Abstract

Metabonomics utilises high resolution analytical platforms to generate spectroscopic profiles that are rich in latent biological information. At present, the two principal analytical platforms used routinely in metabonomic studies are nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS). While these analytical methods in their current state of development in the field of metabonomics give broad coverage across multiple chemical classes, none report sufficiently well, if at all, on the absolute configuration of chiral molecules. As a consequence of the stereospecificity present in biological systems, a very large number of biologically active molecules exhibit chirality. Therefore, an important aspect of the metabolome remains largely unexplored by current metabonomic analytical platforms. Current enantioselective methods exist, but these are largely unsuitable for multi-analyte measurements. The work in this thesis addresses the need for appropriate chiral analytical methods for metabolic profiling. The aim was to develop a practical, fit-for-purpose chiral analytical method that will report simultaneously on numerous endogenous metabolites by untargeted or widely targeted analysis, and importantly, could be aligned with existing analytical workflows. Initial evaluation of an NMR spectroscopic approach using chiral solvating agents concluded that additional spectral complexity and interaction-induced internal reference compound chemical shift instability would prohibit efficient chiral profiling in a metabonomics workflow. An existing targeted MS-based assay for enantioselective separation of amino acids was selected for optimisation and further development. Focused analyses were performed to characterise its performance in the differentiation of individual pairs of enantiomers, and subsequently expanded, first to cover the panel of proteinogenic amino acids, and secondly to other detectable metabolites. Each stage of assay optimisation incorporated an evaluation in a representative set of samples and was able to provide highly relevant biological information that would not be accessible using current achiral metabonomic methods. Further work to expand the number of detectable metabolites and quantitative nature of the assay are discussed.

Published
2017
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45. Canine osteosarcoma in comparative oncology: Molecular mechanisms through to treatment discovery

Author

Siobhan Simpson, Albert A. Rizvanov, Jennie N. Jeyapalan, Simone de Brot, and Catrin S. Rutland

Subjects
bone cancer, canine, genes, human, osteosarcoma, protein, Veterinary medicine, SF600-1100
Abstract

Cancer is a leading cause of non-communicable morbidity and mortality throughout the world, similarly, in dogs, the most frequent cause of mortality is tumors. Some types of cancer, including osteosarcoma (OSA), occur at much higher rates in dogs than people. Dogs therefore not only require treatment themselves but can also act as an effective parallel patient population for the human disease equivalent. It should be noted that although there are many similarities between canine and human OSA, there are also key differences and it is important to research and highlight these features. Despite progress using chorioallantoic membrane models, 2D and 3D in vitro models, and rodent OSA models, many more insights into the molecular and cellular mechanisms, drug development, and treatment are being discovered in a variety of canine OSA patient populations.

Published
2022
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47. Exploring anti-androgen therapies in hormone dependent prostate cancer and new therapeutic routes for castration resistant prostate cancer

Author

Anna E. Harris, Veronika M. Metzler, Jennifer Lothion-Roy, Dhruvika Varun, Corinne L. Woodcock, Daisy B. Haigh, Chantelle Endeley, Maria Haque, Michael S. Toss, Mansour Alsaleem, Jenny L. Persson, Lorraine J. Gudas, Emad Rakha, Brian D. Robinson, Francesca Khani, Laura M. Martin, Jenna E. Moyer, Juliette Brownlie, Srinivasan Madhusudan, Cinzia Allegrucci, Victoria H. James, Catrin S. Rutland, Rupert G. Fray, Atara Ntekim, Simone de Brot, Nigel P. Mongan, and Jennie N. Jeyapalan

Subjects
Therapy, anti-androgen, castration resistant prostate cancer, PARP inhibitors, epigenetic targeted treatment, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

Androgen deprivation therapies (ADTs) are important treatments which inhibit androgen-induced prostate cancer (PCa) progression by either preventing androgen biosynthesis (e.g. abiraterone) or by antagonizing androgen receptor (AR) function (e.g. bicalutamide, enzalutamide, darolutamide). A major limitation of current ADTs is they often remain effective for limited durations after which patients commonly progress to a lethal and incurable form of PCa, called castration-resistant prostate cancer (CRPC) where the AR continues to orchestrate pro-oncogenic signalling. Indeed, the increasing numbers of ADT-related treatment-emergent neuroendocrine-like prostate cancers (NePC), which lack AR and are thus insensitive to ADT, represents a major therapeutic challenge. There is therefore an urgent need to better understand the mechanisms of AR action in hormone dependent disease and the progression to CRPC, to enable the development of new approaches to prevent, reverse or delay ADT-resistance. Interestingly the AR regulates distinct transcriptional networks in hormone dependent and CRPC, and this appears to be related to the aberrant function of key AR-epigenetic coregulator enzymes including the lysine demethylase 1 (LSD1/KDM1A). In this review we summarize the current best status of anti-androgen clinical trials, the potential for novel combination therapies and we explore recent advances in the development of novel epigenetic targeted therapies that may be relevant to prevent or reverse disease progression in patients with advanced CRPC.

Published
2022
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48. Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

Author

Abani, Obbina, Abbas, Ali, Abbas, Fatima, Abbas, Mustafa, Abbasi, Sadia, Abbass, Hakam, Abbott, Alfie, Abdallah, Nabeel, Abdelaziz, Ashraf, Abdelfattah, Mohamed, Abdelqader, Bushra, Abdo, David, Abdul, Basir, Abdul Rasheed, Althaf, Abdulakeem, Ajibode, Abdul-Kadir, Rezan, Abdulle, Amina, Abdulmumeen, Abdulfatahi, Abdul-Raheem, Rasheed, Abdulshukkoor, Niyaz, Abdusamad, Kula, Abed El Khaleq, Yazeed, Abedalla, Mai, Abeer Ul Amna, Abeer Ul Amna, Abernethy, Katrina, Aboaba, Adebanke, Abo-Leyah, Hani, Abou-Haggar, Ahmed, Abouibrahim, Mahmoud, Abraham, Miriam, Abraham, Tizzy, Abraheem, Abraheem, Abrams, Judith, Abu, Hyacinth-John, Abu-Arafeh, Ahmed, Abubacker, Syed M, Abung, Akata, Aceampong, Yaa, Achara, Amaka, Acharya, Devikumar, Acheampong, Sarah, Acheson, Janet, Acosta, Andres, Acton, Catherine, Adabie-Ankrah, Jacqueline, Adair, Sara, Adam, Fiona, Adam, Matthew, Adamali, Huzaifa, Adams, Carol, Adams, Charlotte, Adams, Kate, Adams, Lisa, Adams, Richard, Adams, Tim, Adcock, Kirsty, Addai, Jemaimah, Adebiyi, Ade, Adegoke, Ken, Adell, Vicki, Ademokun, Debo, Adenwalla, Sherna, Adesemoye, Oluwasegun A, Adewunmi, Emmanuel O, Adeyemi, Joyce, Adhikary, Rina, Adkins, Gabrielle, Adnan, Adnan, Aeron-Thomas, John, Affleck, Debbie, Affron, Dominic, Afnan, Carmel, Afridi, Muhammad, Aftab, Zainab A, Agarwal, Meenakshi, Agbeko, Rachel, Agbo, Chris, Agent, Penny, Aggarwal, Sunil, Aghababaie, Arameh, Ahamed Sadiq, Shafana, Ahammed Nazeer, Mohamed H, Ahmad, Humayun, Ahmad, Mohammad, Ahmad, Syed, Ahmed, Asim, Ahmed, Bilal, Ahmed, Forizuddin, Ahmed, Hamze, Ahmed, Iram, Ahmed, Irshad, Ahmed, Khaled, Ahmed, Liban, Ahmed, Mahin, Ahmed, Maria C, Ahmed, Muhammad S, Ahmed, Naseer, Ahmed, Nausheen, Ahmed, Osama, Ahmed, Rajia A, Ahmed, Rizwan, Ahmed, Saif, Ahmed, Sammiya, Ahmed, Sara, Ahmed, Sophia, Ahmed, Syed, Ahmed, Syed Haris, Ahmed Ali, Roa, Ahmed, Sana, Ahmer, Sana, Ail, Dhiraj, Ainsworth, Mark, Airoldi, Giulia, Aissa, Myriam, Aitken, Lindianne, Ajay, Bini, Ajeneye, Francis, Ajibode, 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Chan, Carmen, Chan, Cheuk, Chan, Evelyn, Chan, Kayen, Chan, Kimberley, Chan, Ping, Chan, Rebekah (Pui-Ching), Chan, Xin Hui, Chandler, Chris, Chandler, Heidi, Chandler, Kim J, Chandler, Stuart, Chandler, Zoe, Chandler-Vizard, Vikki, Chandra, Sumit, Chandran, Navin, Chandrasekaran, Badrinathan, Chang, Cherry, Chang, Yvonne, Chaplin, Josephine, Chapman, Graeme, Chapman, John, Chapman, Katie, Chapman, Laura, Chapman, Lianne, Chapman, Polly, Chapman, Timothy, Chappell, Lucy, Chapple, Linda, Charalambou, Amanda, Charles, Bethan, Charlton, Dianne, Charlton, Sally, Chatar, Kevin, Chatha, Calvin, Chaube, Ritesh, Chaudhary, Muhammad YN, Chaudhry, Iram, Chaudhuri, Nazia, Chaudhury, Muhammad, Chauhan, Anoop, Chauhan, Ruchi S, Chauhan, Vipul, Chavasse, Nicola, Chaven, Iknam, Chavez, Rosanna, Chawla, Vipal, Cheadle, Maria, Cheater, Lindsay, Cheaveau, James, Cheeld, Charlotte, Cheeseman, Michelle, Chen, Fang, Chen, Hui Min, Chen, Terence, Cheng, Lok Yin, Cheng, Zhihang, Chenoweth, Helen, Cheong, Chun How, Cherian, Shiney, Cherif, Suzanne, Cherrie, Mary, Cheshire, Helen, Chesterson, Barry, Cheung, Betty, Cheung, Chee Kay, Cheung, Elaine, Cheung, Michelle, Cheyne, Claire, Chhabra, Swati, Chia, Wei Ling, Chiang, Eric, Chiapparino, Angela, Chicano, Rosavic, Chikwanha, Zviedzo A, Chilcott, Sam, Chimbo, Phillipa, Chin, KokWai, Chin, Wen Jie, Chineka, Rumbidzai, Chingale, Amol, Chinn, Karen, Chiroma, Vashira, Chisem, Heather, Chisenga, Claire, Chisnall, Ben, Chiswick, Carolyn, Chita, Sunder, Chitalia, Nihil, Chiu, Matthew, Chivima, Brenda, Chmiel, Catherine, Choi, Soha, Choon Kon Yune, Willy, Choudhary, Vandana, Choudhury, Sarah, Chow, Bing-Lun, Chowdhury, Fateha, Chowdhury, Mahibbur, Chowdhury, Shahid, Christenssen, Victoria, Christian, Peter, Christides, Alexander, Christie, Fiona, Christmas, Daniel, Christopherson, Thereza, Christy, Mark, Chrysostomou, Paris, Chua, Yunli, Chucha, Shabs, Chudgar, Dip, Chudleigh, Richard, Chukkambotla, Srikanth, Chukwu, Michael E, Chukwulobelu, Izu, Chung, Chi Y, Church, Ben, Church, Elaine, Church, Sara R, Churchill, David, Cianci, Nicole, Ciccone, Nick, Cicconi, Paola, Cinardo, Paola, Cipinova, Zdenka, Cipriano, Bessie, Clamp, Sarah, Clapham, Melanie, Clare, Edel, Clare, Sarbjit, Clark, Andrew, Clark, Charlotte, Clark, Diane, Clark, Felicity, Clark, Gabrielle, Clark, James, Clark, Katherine, Clark, Kaylea, Clark, Louise, Clark, Lucy, Clark, Matthew, Clark, Patricia, Clark, Richard, Clark, Thomas, Clark, Wendy, Clark, Zoe, Clarke, Andrea, Clarke, Heather, Clarke, Mark, Clarke, Paul, Clarke, Robert, Clarke, Roseanne, Clarke, Samantha, Clarke, Sarah, Clarke, Sheron, Clarke, Tracy, Clarkson, Andrew, Claxton, Alleyna, Clay, Kate, Clayton, Elizabeth, Clayton, Olivia, Clayton-Smith, Jill, Cleaver, Chris, Clemente de la Torre, Carlota, Clements, Jayne, Clements, Suzanne, Clemons, Francesca, Clifford, Lee, Clifford, Lynne, Clifford, Rachael, Clifford, Sarah, Clive, Amelia, Clouston, Jonathan, Clueit, Samantha, Clyne, Andrea, Coakley, Michelle, Coakley, Peter G L, Coates, Tony, Cobain, Kathryn, Cochrane, Alexandra, Cochrane, Patricia, Cockerell, Maeve, Cockerill, Helen, Cocks, Shirley, Codling, Rachel, Coe, Adam, Coetzee, Samantha, Coey, David, Cohen, Danielle, Cohen, Jonathan, Cohen, Oliver, Cohn, Mike, Coke, Louise, Coker, Olutoyin, Colbeck, Nicholas, Colbert, Roghan, Cole, Carol, Cole, Esther, Cole, Jade, Cole, Joby, Cole, Julie, Cole, Richard, Cole, Sue, Coleman, Garry, Coleman, Matt, Coles, Holly, Coles, Rebecca, Colin, Macleod, Colino-Acevedo, Alicia, Colley, Julie, Collier, Dawn, Collier, Heather, Collini, Paul, Collins, Emma, Collins, Jaimie, Collins, Joanne, Collins, Nicola, Collins, Sally, Collins, Vicky, Collinson, Andrew, Collinson, Bernadette, Collinson, Jennifer, Collis, Matthew, Colmar, Madeleine, Colton, Hayley E, Colton, James, Colville, Katie, Colvin, Carolyn, Colwell, Ryan, Combes, Edward, Comer, David, Comerford, Alison, Comery, Mike, Concannon, Dónal, Condliffe, Robin, Connell, Lynne, Connell, Natalie, Connelly, Karen, Connolly, Gavin, Connolly, Mireille, Connor, Emma, Conran, Samantha, Conroy, Antonia, Conteh, Veronica, Convery, Rory, Conway, Camilla, Conway, Francesca, Conway, Grainne, Conway, Rhiannon, Conyngham, Jo-Anna, Cook, Colette, Cook, Eloise, Cook, Gemma, Cook, Helen, Cook, Julie, Cooke, Danielle, Cooke, Graham, Cooke, Katrina, Cooke, Soo, Cooke, Tim, Cooper, Adele, Cooper, Alison, Cooper, Chris, Cooper, David, Cooper, Helen, Cooper, Jamie, Cooper, Joanne, Cooper, Joshua, Cooper, Laura, Cooper, Lauren, Cooper, Nick, Cooper, Rowena, Cooperwaite, Emma, Cope, Thomas, Corbet, Sinead, Corbett, Carolyn, Corcoran, John, Cordell, Chris, Cordle, Jessica, Corfield, Alasdair, Corless, John, Corlett, Alison, Cornwell, Joe, Cornwell, Michael, Corogeanu, Diana, Corredera, Mirella, Corrigan, Ruth, Corry, Catherine, Corser, Rita, Cosgrove, Denise, Cosier, Tracey, Costa, Patricia, Coston, Charlie, Cotgrove, Susannah, Coton, Zoe, Cottam, Lisa-Jayne, Cotter, Rhiannon, Cotterill, Donna, Cotton, Alice, Cotton, Caroline, Cotton, Katy, Coull, Andrew, Coulson, James, Counsell, David, Counter, David, Coupland, Cherry, Courtney, Ellie, Courtney, Julia, Cousins, Rebecca, Cowan, Alexander, Cowan, Elena, Cowburn, Ruth, Cowell, Richard, Cowen, Louise, Cowman, Steve, Cowton, Amanda, Cox, Debra Anne, Cox, Ellie, Cox, Giles, Cox, Karina, Cox, Miriam, Coy, Karen, Craig, Beverly, Craig, Victoria, Craighead, Felicity, Cramp, Matthew, Crane, Beverley, Crause, Jacolene, Crawford, Adrian, Crawford, Angie, Crawford, Emma, Crawford, Isobel, Crawforth, Richard, Crawshaw, Sarah, Creagh-Brown, Ben, Creamer, Andrew, Creighton, Ryan, Cremona, Joanne, Cremona, Saveria, Cresswell, Janet, Cribb, Mark, Crichton, Charles, Crilly, Declan, Crisp, Lauren, Crisp, Nikki, Crocombe, Dominic, Croft, Maria, Cron, Ian, Crook, Derrick, Crooks, Jennifer, Croot, Helen, Crosby, Harriet, Cross, Sarah, Cross, Tim, Crothers, Amy, Crotty, Stephen, Crouch, Susan, Crow, Madeleine, Crowder, Amanda, Crowley, Kate, Crowley, Teresa, Croysdill, Rebecca, Cruickshank, Callum, Cruickshank, Conor, Cruickshank, Irena, Cruise, James, Crumley, Helen, Cruz, Carina, Cruz Cervera, Trino, Cryans, Dominic, Cui, Guanguo, Cui, Helen, Cullen, Donna, Cullen, Lorraine, Cummings-Fosong, Gillian, Cundall, Marie, Cunliffe, Victoria, Cunningham, Lorraine, Cunningham, Neil, Cunningham, Nicola, Cupitt, Jason, Curgenven, Hollie, Curley, Debra, Curnow, Gerens, Curran, David, Curran, Simon, Currie, Craig, Currie, Jacqueline, Currie, Scarlett, Curtis, Abi, Curtis, Becca, Curtis, Jonathan, Curtis, Katrina, Curtis, Olivia, Curtis, Thomas, Cuthbertson, Rebecca, Cutler, Sean, Czekaj, Marta, Czylok, Patrycja, da Rocha, Joana, Dagens, Andrew, Daggett, Helen, Daggett, Phil, Daglish, Jacqui, Dahiya, Sandeep, Dakers-Black, Helen, Dale, Anne, Dale, Katie, Dale, Michaela, Dale, Sam, Dales, Jolyon, Dalgleish, Helen, Dallas, Nikki, Dallow, Helen, Dalton, Dermot, Daly, Zoe, Danga, Akila, Daniel, Amelia, Daniel, Priya, Daniels, Allison, Dann, Adela, Danso-Bamfo, Sandra, Daoud, Nimo, Darbyshire, Alex, Darbyshire, Janet, Dargan, Paul, Dark, Paul, Darling, Tace, Darlington, Kate, Darton, Tom, Darylile, Guledew, Das, Manjusha, Das, Sukamal, Daschel, Martin, Dasgin, Joanne, Datta, Dibyendu, Daunt, Anna, Davenport, Emily, Davey, Mark, Davey, Michelle, Davey, Miriam, Davey, Molly, David, Arlene, David, Mini, Davidson, Alexander, Davidson, Laura, Davidson, Neil, Davidson, Richard, Davies, Albert, Davies, Alison, Davies, Amanda, Davies, Amy, Davies, Angela, Davies, Carolyn, Davies, Catrin, Davies, Cheryl, Davies, Drew, Davies, Elaine, Davies, Ffyon, Davies, Helen, Davies, James, Davies, Jane, Davies, Jeni, Davies, Jim, Davies, Karen, Davies, Kelly, Davies, Kim, Davies, Louisa, Davies, Mark, Davies, Matthew, Davies, Michelle, Davies, Nina, Davies, Owen, Davies, Patrick, Davies, Rachel, Davies, Rhys, Davies, Ruth, Davies, Sarah, Davies, Simon, Davis, Alison, Davis, Gwyneth, Davis, Illinos, Davis, Julie-Ann, Davis, Katherine, Davis, Peter, Davison, Alexander, Davison, Sophia, Davy, Mark, Dawe, Christine, Dawe, H, Dawkins, Mark, Dawson, Danielle, Dawson, Elizabeth, Dawson, Joy, Dawson, Susan, Dawson, Tom, Daxter, Andrew, Day, Andrew, Day, Helena, Day, Jacob, Day, Jeremy, Day, Lynn, D'Costa, Jamie, De, Parijat, de Fonseka, Duneesha, de Freitas, Toni, De Santana Miranda, Frederico, de Sausmarez, Eleanor, de Silva, Shanika, de Silva, Thushan, De Sousa, Jessica, De Sousa, Paulo, de Souza, James, de Soyza, Anthony, de Vere, Natasha, de Vos, Johannes, Deacon, Bethan, Dealing, Sharon, Dean, Anna, Dean, Julie, Dean, Katrina, Dean, Stephen, Dean, Tessa, Deane, Jill, Dear, James, Dearden, Effie, Deary, Alison, Deas, Catherine, Debbie, Samuel, Debreceni, Gabor, Deelchand, Vashist, Deeley, Matthew, Deery, Joanne, Defever, Emmanuel, Dehulia, Raji, Deighton, Max, Del Forno, Manuela, Dela Rosa, Arnold, Delaney, Lisa, Dell, Amanda, Demetriou, Carrie, DeMets, David, Democratis, Jane, Denham, Jacqueline, Denis, Emmanuelle, Denley, Laura, Denmade, Craig, Dent, Kathy, Dent, Martin, Denton, Elise, Denwood, Tom, Deole, Nishigandh, Depala, Darshita, Depante, Maria, Derbyshire, Randle, Dermody, Susan, Desai, Amisha, Desai, Asmita, Desai, Purav, Deshpande, Sanjeev, Deshpande, Vai, Devine, Brendan, Devkota, Sirjana, Dewland, Nicola, Dey, Prakash, Dey, Vishal, Deylami, Rogin, Dhaliwal, Jazz, Dhaliwal, Kevin, Dhalliwal, Jas, Dhanda, Mandeep, Dhani, Sundip, Dhanoa, Amandeep, Dhar, Mili, Dhasmana, Devesh, Dhesi, Aman, Dhillon, Ekanjali, Dhillon, Reiss, Diamond, Pamela, Dias, Priya, Diaz, Stephanie, Diaz-Pratt, Kayleigh, Dickerson, Debbie, Dicks, Pamela, Dickson, Stuart, Dijo, Julie, Dillane, Sean, Diment, Sarah, Dimitri, Paul, Dineen, Maria, Dinh, ThaiHa, Dinh, Tri, Dipper, Alex, Dirmantaite, Laura, Ditchfield, Lisa, Diver, Sarah, Diwakar, Lavanya, Dixon, Caroline, Dixon, Giles, Dixon-Mould, Stephen, Djeugam, Brice, Dlouhy, Petr, Dobbie, Laurence, Dobranszky Oroian, Marinela, Dobson, Charlotte, Dobson, Lee, Docherty, Marie, Dockrell, David, Dodd, James, Dodds, Jackie, Dodds, Rebecca, Dodds, Steve, Dogra, Richi, Doherty, Erin, Doherty, Warren, Doi, Yumiko, Doig, Iain, Doke, Eleanor, Dolan, Daniel, Dolman, Mark, Dolman, Rozzie, Donald, Lisa, Donaldson, Callum, Donaldson, Christopher, Donaldson, Denise, Donaldson, Gillian, Donaldson, Kate, Donnachie, Joanne, Donnelly, Christopher, Donnelly, Eilish, Donnelly, Ronan, Donohoe, Aravindhan, Donohoe, Gemma, Donohue, Bryan, Donton, Sinead, Dooks, Emma, Doran, Grainne, Dorey, Kane, Dorgan, Sharon, Dornan, Amanda, Dosani, Moonira, Dosanjh, Davinder, Dospinescu, Paula, Douglas, Katie, Douse, Jonathan, Dowden, Lucy, Dower, Michelle, Dowling, Kerry, Dowling, Sud, Downer, Nicola, Downes, Charlotte, Downes, Rob, Downes, Thomas, Downey, Damian, Downey, Philippa, Downey, Robert, Downs, Louise, Dowson, Simon, Dragan, Cornel, Dragomir, Cristina, Dragos, Cristina, Drain, Maire, Drake, Chelsea, Drew, Victoria, Drewett, Olivia, Driscoll, Celine, Drogan, Helena, Drogman, Nikki, Drummond, Graham, Druyeh, Ronald, Drysdale, Simon, Du Thinh, An, Dube, Hazel, Dube, Judith, Dube, Ophias, Duberley, Stephen, Duckles-Leech, Hayley, Duff, Nicola, Duffield, Emma, Duff-Miller, Sam, Duffy, Helen, Dufour, Lionel, Duggan, Annette, Duggan, Helen, Dugh, Parveen, Duignan, Janice, Duley, Mick, Dummer, Simon, Duncan, Andrew, Duncan, Christopher, Duncan, Fullerton, Duncan, Gregory, Dundas, Stephanie, Dunn, Alessia, Dunn, Charlotte, Dunn, Damian, Dunn, Laura, Dunn, Paul, Dunne, Charlene, Dunne, Karen, Dunning, Fiona, Dunphy, Aidan, Duraiswamy, Venkat, Duran, Beatriz, DuRand, Ingrid, Durgacharan, Steve, Duric, Natalie, Durie, Alison, Durie, Emily, Durrington, Hannah, Duvnjak, Haris, Dwarakanath, Akshay, Dwarakanath, Laasya, Dwyer, Ellen, Dyball, Claudia, Dyble, Lee, Dyer, Kristyn, Dymond, Harvey, Dymond, Tom, Eades, Chris, Eagles, Laura, Early, Joanne, Earwaker, Melissa, Easom, Nicholas, East, Clare, East, Kim, Easthope, Amy, Easton, Fraser, Eaton, Caroline, Eaton-Howell, Caroline, Eatough, Ruth, Ebbs, Adrian, Ebigbola, Oluwadamilola, Ebner, Daniel, Ebon, Martin, Eccles, Sinan, Eddings, Chloe, Eddleston, Michael, Edgar, Maureen, Edgerley, Katharine, Edmond, Nicholas, Edmonds, Julie, Edmondson, Dave, Edmondson, Mary, Edmunds, Tracy, Edwards, Alexandra, Edwards, Catherine, Edwards, Joy, Edwards, Kennedy, Edwards, Mandy, Edwards, Tomos, Eedle, Jenny, Egginton, Dawn, Ehiorobo, Loveth, Eisen, Sarah, Ekeowa, Ugochukwu, Ekoi, Mohamed, Ekunola, Ayomide, El Behery, Soha, El-Agnaf, Moulod, Elbeshy, Mohamed, El-Bouzidi, Kate, Elder, Jennifer, El-Din, Mohammed, Eleanor, Diana, Eletu, Ibrahim, Elfar, Eman, Elgamal, Mayy Magdy, Elgohary, Amr, Elia, Stellios, Elias, Jennifer, Elias, Tania, Elkaram, Nadia, El-Karim, Mohammed, Elkins, Andrew Victor, Ellam, Julie, Ellard, Nikki, Ellerton, Laura Nicola, Elliot, Lucy, Elliott, Amy, Elliott, Chris, Elliott, Fiona, Elliott, Kerry, Elliott, Scott, Elliott, Toby, Ellis, Annie, Ellis, Ann-Marie, Ellis, Christine, Ellis, Kay, Ellis, Kaytie, Ellis, Tak-Yan, Ellis, Yvette, Ellison, Megan, Elmahdi, Rahma, Elmahi, Einas, Elmasry, Hannah-May, Elmi, Mohammed, Elndari, Najla, Elneima, Omer, Elokl, Mohamed, Elradi, Ahmed, Elsaadany, Mohamed, El-Sayeh, Sally, El-Sbahi, Hana, Elsefi, Tarek, El-Shakankery, Karim, Elshaw, Robert, El-Taweel, Hosni, Elyoussfi, Sarah, Emberey, Jonathan, Emberson, Jonathan R, Emberton, John, Emmanuel, Julian, Emmerson, Ingrid, Emms, Michael, Emond, Florence, Emonts, Marieke, Enachi, Nicu, Engden, Angila, English, Katy, Entwistle, Emma, Enyi, Hene, Erotocritou, Marios, Escreet, Helen, Eskander, Peter, Esmail, Hanif, Estcourt, Lise, Evans, Amy, Evans, Brynach, Evans, Chris, Evans, Daren, Evans, Debra, Evans, Gail, Evans, Gareth, Evans, Jennifer, Evans, Lisa, Evans, Lynn, Evans, Margaret, Evans, Michelle, Evans, Mim, Evans, Morgan, Evans, Ranoromanana, Evans, Ryan, Evans, Teriann, Evans, Terry John, Eve, Tony, Everden, Caroline, Everden, Serenydd, Evison, Hayley, Evison, Lynsey, Eyton-Jones, Penny, Faccenda, Jacqueline, Fahel, Leila, Fahmay, Youstina, Fairbairn, Sara, Fairbairn, Terry, Fairclough, Andy, Fairlie, Louise, Fairweather, Mark, Fajardo, Anne, Falcone, Naomi, Falconer, Euan, Falconer, Jonathan, Fallon, John, Fallow, Andrea, Faluyi, David, Fancois, Victoria, Farah, Qayyum, Fard, Novin, Farg, Amr, Farinto, Margaret, Farmer, Adam, Farmer, Katie, Farmery, Toni, Farnworth, Samantha, Farook, Faiyaz, Farooq, Hadia, Farooq, Sidrah, Farquhar, Fiona, Farrar, Karen, Farrell, Aaron, Farrell, Barbara, Farthing, James, Farzana, Syeda, Fasina, Rahmatu, Fatemi, Azam, Fatemi, Mina, Fatimah, Nibah, Faulkner, Maria, Faust, Saul N, Fawke, Joe, Fawohunre, Sinmidele, Fazal, Abul, Feane, Kelly, Fearby, Simon, Feben, Alex, Fedel, Federico, Fedorova, Daria, Feely-Henderson, James, Fegan, Christopher, Felongco, Mae, Felton, Lynsey, Felton, Tim, Fenlon, Kate, Fenn, Andrea, Fenner, Isabelle, Fenton, Ciara, Fenton, Melisa, Ferguson, Cameron, Ferguson, Jenny, Ferguson, Kathryn, Ferguson, Katie, Ferguson, Stephanie, Ferguson, Susan, Ferguson, Susie, Ferguson, Victoria, Fernandes, Denzil, Fernandez, Candida, Fernandez, Eduardo, Fernandez, Maria, Fernandez Lopez, Sonia, Fernando, Callum Jeevan, Feroz, Ahmed, Ferranti, Pietro, Ferrari Gersogamo, Thais, Ferrelly, Eleanor, Ferrera, Alexandra, Ferriman, Emma, Fethers, Nicholas, Field, Ben, Field, Janet, Field, Rebecca, Fielder, Karen, Fieldhouse, Lindsey, Fielding, Andra, Fielding, Julie, Fielding, Len, Fielding, Sarah, Fikree, Asma, Filson, Sarah Ann, Finbow, Sarah, Finch, Debbie, Finch, Joanne, Finch, Laurie, Finden, Joanne, Fineman, Natalie, Finlayson, Lauren, Finn, Adam, Finn, Joanne, Finney, Clare, Fiouni, Sofia, Fiquet, Jo, Fisher, Dani, Fisher, Emily, Fisher, James, Fisher, Neil, Fisher Crisp, Meadow, Fishman, Daniel, Fishwick, Krystofer, Fitzgerald, Lorraine, Fitzpatrick-Creamer, Chloe, Flaherty, Jan, Flanagan, Michael, Flanders, Charles, Flatters, Cathy, Fleming, Julie, Fleming, Lucy, Fleming, Paul, Flesher, William, Fletcher, Alison, Fletcher, Jonathan, Fletcher, Lucy, Fletcher, Simon, Fletcher, Sophie, Flewitt, Karen, Flood, Christopher, Floodgate, Ian, Florence, Vincent, Floyd, Sharon, Flynn, Kelly, Flynn, Rachel, Flynn, Sara, Foden, Claire, Fofana, Adama, Fogarty, Georgina, Foley, Claire, Foley, Paul, Folkes, Linda, Font, Daniela Mock, Fonyonga, Evodian, Foo, Aiwyne, Foo, Jane, Foot, Andrew, Foot, Jayne, Forbes, Jane, Ford, Jamie, Ford, Kathy, Foreman, Jennifer, Fornolles, Caroline, Forrest, Adam, Forsey, Ellie, Forsey, Miranda, Forshall, Thomas, Forster, Elliot, Forton, Julian, Foster, Emily, Foster, Joseph, Foster, Rachel A, Foster, Tracy, Foukanelli, Theodora, Foulds, Angela, Foulds, Ian, Fowe, Folakemi, Fowler, Emily, Fowler, Robert, Fowler, Stephen, Fox, Caroline, Fox, Claire, Fox, Daniel, Fox, Heather, Fox, Jonathan, Fox, Lauren, Fox, Natalie, Fox, Olivia, Fox, Simon, Foxton, Sarah-Jane, Fozdar, Yasin, Frake, Rebecca, Francioni, Alex, Francis, Olesya, Francis, Rebecca, Francis, Sarah, Francis-Bacon, Theodora, Frankcam, Jason, Frankland, Helen, Franklin, Gayle, Franklin, Jessica, Franks, Darron, Fraser, Catherine, Fraser, Laura, Frayling, Sharon, Fredlund, Martyn, Free, Matthew, Freeman, Carol, Freeman, Elaine, Freeman, Hannah, Freeman, Nicola, Freer, Clare, Freestone, Ian, French, Eleanor, Frise, Matthew, Fromson, Renate, Froneman, Claire, Frosh, Adam, Frost, John, Frost, Victoria, Froud, Oliver, Frowd, Rachel, Fryatt, Arun, Fryer, Jake, Fu, Janet, Fuller, Bridget, Fuller, Liz, Fuller, Neil, Fuller, Tracy, Fullerton, Duncan, Fullthorpe, Jenny, Fung, Carrie, Fung, Gayle, Funnell, Sarah, Furness, John, Furtado, Charlene, Fyfe, Andrew, G, Nytianandan, Gabbitas, Elizabeth, Gabriel, Claire, Gabriel, Diana, Gachi, Hadiza, Gad, Rose, Gahir, Joshua, Gajebasia, Sarveen, Gajewska-Knapik, Katarzyna, Galani, Zacharoula, Gale, Christopher, Gale, Hugo, Gale, Rebecca, Gali, Swetha, Galilee, Karen, Gallagher, Bernadette, Gallagher, Jude, Gallagher, Rosie, Gallagher, William, Galliford, Joanne, Galloway, Catherine, Galloway, Chris, Galloway, Emma, Galloway, Jacqui, Galloway, James, Gamble, Laura, Gamble, Liz, Gammon, Brian, Ganapathi, Jaikumar, Ganapathy, Ramesh, Gandhi, Kaminiben, Gandhi, Sarah, Ganesh, Usha, Gani, Abrar, Garden, Emma-James, Gardener, Antoni D, Gardiner, Emma, Gardiner, Jill, Gardiner, Michael, Gardiner, Phil, Gardiner, Siobhan, Gardiner-Hill, Caroline, Gardner, Jonathan, Garfield, Mark, Garg, Atul, Garlick, Nathan, Garner, Justin, Garner, Lucie, Garner, Zoe, Garnett, Kimberley, Garney, Robert, Garr, Rosaline, Garstka, Michael, Gartan, Peter, Garty, Florence, Gascoyne, Rachel, Gashau, Hyeriju, Gasmalseed, Noha, Gaspar, Michaela, Gatenby, Aoife, Gaughan, Erin, Gaurav, Alok, Gavrila, Mariana, Gaylard, Jane, Gaywood, Emma, Geddie, Catherine, Geddis, Alison, Gedge, Ian, Gee, Sarah, Gellamucho, Minerva, Gelly, Karzan, Gelmon, Leila, Gelves-Zapata, Sandra, Genato, Gemma, Gent, Susan, Geoghegan, Natalie, George, Chloe, George, Sam, George, Tina, Georges, Simon, Georgiou, Domonique, Gerard, Peter, Gerdes, Leigh, Germain, Louise, Gerrish, Helen, Getachew, Abel, Gethin, Louise, Ghanayem, Hisham, Ghattaoraya, Amardeep, Gherman, Anca, Ghosh, Alison, Ghosh, Justin, Ghosh, Sudhamay, Giannopoulou, Sarra, Gibani, Malick, Gibb, Andrew, Gibbison, Ben, Gibbons, Kerry, Gibson, Alex, Gibson, Bethan, Gibson, Kimberley, Gibson, Kirsty, Gibson, Sian, Gilbert, Cat, Gilbert, Jeanette, Gilbert, Joanne, Gilbert, Kayleigh, Gilchrist, Sean, Giles, Benjamin, Gill, Mandy, Gill, Rose, Gill, Lynne, Gillen, Paul, Gillesen, Annelies, Gillespie, Katherine, Gillespie, Matt, Gillham, Elizabeth, Gillian, Andrew, Gilliland, Deborah, Gillott, Robert, Gilmour, Danielle, Gilmour, Kate, Giokanini-Royal, Theodora, Gipson, Anna, Girling, Joanna, Gisby, Rhian, Gkioni, Angelena, Gkoritsa, Aikaterini, Gkrania-Klotsas, Effrossyni, Gladwell, Amy, Glanville, James, Glasgow, Jessica, Glasgow, Susannah, Glass, Jon, Glass, Lynn, Glaysher, Sharon, Gledhill, Lisa, Glennon, Ana, Glover, John, Glover, Kyle, Glover Bengtsson, Jan, Gnanalingam, Chevanthy, Goddard, Julie, Goddard, Wendy, Godden, Emily, Godden, Jo, Godding, Gillian, Godson, Emma, Gogarty, Gerry, Gogoi, Sukanya, Goh, Aiky, Goiriz, Rebeca, Gokaraju, Sriya, Gold, Philip, Goldacre, Raphael, Goldsmith, Arthur, Goldsmith, Portia, Gomersall, Darren, Gomez, Lucia, Gomez-Marcos, Raquel, Gondal, Ali, Gonzalez, Celia, Goodall, Jack, Goodenough, Bob, Goodfellow, Laura, Goodlife, James, Goodwin, Camelia, Goodwin, Elizabeth, Goodwin, Jayne, Goodyear, Paula, Gooentilleke, Rajiv, Goolam-Hossen, Sharif, Goonasekara, Michelle, Gooseman, Sheila, Gopal, Shameer, Gordon, Peter, Gordon, Sally, Gorick, Hugh, Gorman, Caitlin, Gorman, Claire, Gormely, Stuart, Gorog, Diana, Gorry, Jan, Gorst, Michelle, Gorsuch, Thomas, Gosai, Jayshreebahen, Gosling, Rebecca, Gosling, Sally, Gosney, Georgina, Goss, Vanessa, Gotham, Dzintars, Gott, Naomi, Goudie, Elizabeth, Gould, Amanda, Gould, Angela, Gould, Susan, Gourbault, Lysander, Gouveia, Anna, Govind, Abha, Gowans, Sharon, Gowda, Girish, Gowda, Rohit, Gowdy, Pauline, Gower, Hannah, Gower, Thomas, Goyal, Pankaj, Goyal, Sunil, Goyal, Sushant, Graham, Beverley, Graham, Clive, Graham, Jane, Graham, Jonathan, Graham, Justin, Graham, Libby, Graham, Sharon, Graham-Brown, Matthew, Grahamslaw, Julia, Grana, Gianluca, Grandison, Tracyanne, Grandjean, Louis, Grant, Alison, Grant, Ann, Grant, David, Grant, Matthew, Grant, Pauleen, Gravell, Rhys, Graves, Jenny, Gray, Alasdair, Gray, Catherine, Gray, Georgina, Gray, Harriet, Gray, Ingrid, Gray, Jackie, Gray, Karen, Gray, Nicola, Gray, Sebastian, Grayson, Alan, Grealish, Patricia, Greaves, Fiona, Greaves, Jack, Greaves, Paul, Green, Charlotte, Green, Christopher, Green, David, Green, Frederick, Green, Grace, Green, Joel, Green, Marie, Green, Nicola, Green, Stacey, Green, Teresa, Greene, Diarra, Greenfield, Philippa, Greenhalgh, Alan, Greenslade, Maraneka, Greenwood, Daniel, Greer, Sandra, Gregory, James, Gregory, Jane, Gregory, Katie, Gregory, Tamsin, Gregson, James, Greig, Jill, Greig, Julia, Grenfell, Rebecca, Grenier, Teena, Grevatt, Susan, Grey, Glaxy, Gribbin, Andrew, Gribble, Amy, Grice, Beverley, Grieg, Natasha, Grieve, Douglas, Griffin, Ben, Griffin, Denise, Griffin, Mel, Griffith, Sian, Griffiths, Alexandra, Griffiths, Andrew, Griffiths, Daniel, Griffiths, David, Griffiths, Donna, Griffiths, Isabel, Griffiths, Mark, Griffiths, Nicola, Griffiths, Oliver, Griffiths, Sarah, Griffiths, Sharon, Griffiths, Yvonne, Grigoriadou, Sofia, Grigsby, Steph, Grist, Paul, Grist, Stephen, Grobovaite, Evelina, Grondin, Clarissa, Groome, Rachel, Grosu, Liliana, Grounds, Jenny, Grout, Margaret, Grover, Helen, Groves, Jayne, Grubb, Neil, Grundy, Julie, Guarino, Francesca, Gudur, Sharada, Guettari, Sharazeq, Gulati, Shivang, Gulia, Vikas, Gunasekera, Pumali, Gunawardena, Malin, Gunganah, Kirun, Gunn, Jessica, Gunter, Emma, Gupta, Alok, Gupta, Atul, Gupta, Rajeev, Gupta, Richa, Gupta, Rishi, Gupta, Tarun, Gupta, Vineet, Gupta-Wright, Ankur, Guratsky, Victoria, Gureviciute, Alvyda, Gurram, Sambasivarao, Gurung, Bhawana, Gurung, Shraddha, Guth, Hazel, Habibi, Ruth, Hack, Berkin, Hackney, Pamela, Hacon, Christian, Haddad, Aiman, Hadfield, Denise, Hadjiandreou, Michalis, Hadjisavvas, Nikolaos, Hadzik, Leah, Haestier, Anna, Hafiz, Nauman, Hafiz-Ur-Rehman, Rana, Hafsa, Javed, Hagan, Samantha, Hague, Jack W, Hague, Rosemary, Haigh, Kate, Haines, Christina, Hainey, Scott, Hair, Morton, Hairsine, Brigid, Hajnik, Juraj, Haldeos, Anne, Halder, Writaja, Hale, Jennie, Halevy, Carmel, Halford, Paul, Halford, William, Hall, Alistair, Hall, Anthony, Hall, Claire, Hall, Elizabeth, Hall, Emma, Hall, Fiona, Hall, Helen, Hall, Jennifer, Hall, Kathryn, Hall, Bill, Hallas, Jan, Hallas, Kyle, Hallett, Charles, Halls, Becky-Lee, Halls, Heather, Hamdollah-Zadeh, Maryam, Hameed, Bilal, Hamid, Imran, Hamie, Mohamad, Hamilton, Bethany, Hamilton, Fergus, Hamilton, Leigh, Hamilton, Nicola, Hamlin, Ruth, Hamlyn, Eleanor, Hammans, Beatrice, Hammersley, Shirley, Hammerton, Kate, Hammond, Bev, Hammond, Leah, Hammond, Sara, Hammonds, Fiona, Hamoodi, Ibrahim, Hampshire, Karen, Hampson, Elizabeth, Hampson, Jude, Hampson, Lucy, Hanci, Ozan, Hancock, Ian, Hand, Sadiyah, Handford, Jasmine, Handrean, Soran, Haney, Sarah, Hanif, Sheharyar, Hanison, E, Hanlon, Alison, Hannah, Jennifer, Hannington, Amy, Hannun, Merhej, Hanrath, Aidan, Hanson, Anita, Hanson, Jane, Hanson, Kathryn, Hanson, Steve, Hanwell, Helen, Haq, Mazhar Ul, Haqiqi, Ala, Haque, Monjurul, Harden, Lesley, Harding, Zoe, Hardman, Simon, Hardy, Joanna, Haresh, Kumar, Harford, Rachel, Hargadon, Beverley, Hargreaves, Carolyn, Hargreaves, Emily, Hargreaves, James, Harin, Alice, Haris, Mohammed, Harlock, Edward, Harlow, Sandra, Harman, Paula, Harman, Tracy, Harmer, Mark, Haroon, Muhammad A, Harper, Charlie, Harper, Fiona, Harper, Heather, Harper, Melanie, Harper, Peter, Harper, Rosemary, Harrhy, Sarah, Harrington, Sian, Harrington-Davies, Yasmin, Harris, Jade, Harris, Jess, Harris, John, Harris, Laura, Harris, Marie-Clare, Harris, Naomi, Harris, Nichola, Harris, Sophie, Harrison, Alex, Harrison, David, Harrison, Julie, Harrison, Laura, Harrison, Melanie, Harrison, Rowan, Harrison, Susie, Harrison, Thomas, Harrison, Wendy, Harrod, Elizabeth, Hart, Ciaran, Hart, Dominic, Hartley, Lisa, Hartley, Rosemary, Hartley, Ruth, Hartley, Tom, Hartrey, William, Hartridge, Phillipa, Hartshorn, Stuart, Harvala, Heli, Harvey, Alice, Harvey, Angela, Harvey, Max, Harwood, Catherine, Harwood, Helen, Haselden, Brigitte, Hashem, Kazi, Hashimm, Mohammed, Hashimoto, Tadaaki, Hashmi, Imranullah, Haskins, Sarah, Haslam, Zena, Hassan, Adil, Hassan, Ali, Hassan, Wagae UI, Hassan, Waqar Ul, Hassasing, Sapna, Hassell, Jane, Hassell, Philip, Hastings, Alex, Hastings, Bethany, Hastings, Janice, Hatch, Stephanie, Hatton, Jonathan, Haviland, Sheryl, Havinden-Williams, May, Havlik, Stefan, Hawcutt, Daniel B, Hawes, Kadean, Hawes, Liz, Hawes, Nicola, Hawkins, Annie, Hawkins, Catherine, Hawkins, Nancy, Hawkins, Tanya, Hawley, Dan, Hawley-Jones, Ed, Haworth, Edward, Hay, Cathy, Hayat, Amna, Hayat, Jamal, Hayathu, Mohamed-Riyal, Haydon, Tamsin, Hayes, Anne, Hayes, Jonas, Hayes, Kate, Hayes, Melony, Hayes, Vanessa, Hayes, Fiona, Hayle, Patrick, Haylett, Chloe, Hayman, Antara, Hayman, Melanie, Haynes, Matthew, Haynes, Richard, Hayre, Rachel, Haysom, Sarah, Hayward, James, Haywood, Patrick, Hazelton, Tracy, Hazenberg, Phoebe, He, Zhengmai, Headon, Elizabeth, Heal, Carrie, Healy, Brendan, Hearn, Amy, Heath, Angela, Heath, Rowan, Heaton, Diane, Hebbron, Kerry, Hector, Gemma, Hedges, Andy, Hedges, Katrine, Heeley, Cheryl, Heeney, Elaine, Heire, Rajdeep, Hemmila, Ulla, Hemmings, Cassie, Hemphill, Scott, Hemsley, Deborah, Henderson, Abigail, Henderson, Jennifer, Henderson, Steven, Hennen, Lee, Hennessy, Kathryn, Hennesy, Natalie, Henry, Carol Ann, Henry, Joanne, Henry, Karol, Henry, Lavinia, Henry, Margo, Henry, Natalie, Henshall, David, Herbert, Mike, Herdman, Gillian, Herdman-Grant, Rosaleen, Herkes, Morag, Heron, Emma, Heron, Kay, Herrington, William, Heselden, Emilia, Heslop, Peta, Hesson, Sharnie Beth, Hester, Simon, Hetherington, Emily, Hetherington, Joseph, Hettiarachchi, Chamila, Hettiarachchi, Pramodh, Hewer, Hayley, Hewertson, John, Hewetson, Anna, Hewins, Sue, Hewitson, Jacqueline, Hewitt, Claire, Hewitt, Davina, Hewitt, Richard, Heyderman, Robert, Heydon, Nicolette, Heydtmann, Mathis, Heys, Joseph, Heywood, Jonathan, Heywood-Beldon, Gareth, Hibbert, Meg, Hickey, John, Hickey, Naomi, Hickey, Peter, Hicks, Alex, Hicks, Jenny, Hicks, Rosie, Hicks, Scott Rory, Higbee, Daniel, Higgins, Lucy, Higham, Andrew, Highcock, Martin, Highgate, Judith, Hikmat, Mondy, Hill, Alison, Hill, Amanda, Hill, Helen, Hill, Joanne, Hill, Lisa, Hill, Martin, Hill, Phoebe, Hill, Uta, Hilldrith, Annette, Hillerby, Elizabeth, Hillman-Cooper, Catherine, Hilton, Elisabeth, Hilton, Zoe, Hinch, Sarah, Hinde, Marcus, Hindle, Andrew, Hindmarsh, Alice, Hine, Paul, Hinshaw, Kim, Hird, Clare, Hirst, Alison, Hives, Jemma, Ho, Benson, Hoare, Michaela, Hobden, David, Hobden, Gill, Hobrok, Maria, Hobson, Simon, Hodge, Renate, Hodge, Simon, Hodgen, Lesley, Hodgkins, Holly, Hodgkinson, Louise, Hodgkinson, Sally, Hodgson, David, Hodgson, Helen, Hodgson, Luke, Hodgson, Sheila, Hodkinson, Gemma, Hodson, Kenneth, Hogben, Matthew, Hogg, Lucy, Hoggett, Lee, Holborow, Abigail, Holbrook, Catherine, Holden, Catherine, Holden, Melinda, Holder, Thomas, Holdhof, Niels, Holdsworth, Hannah, Holland, Lisa, Holland, Maureen, Holland, Nicky, Hollands, Marie, Holliday, Elizabeth, Holling, Nina, Hollis, Gillian, Hollos, Laszlo, Holloway, Linda, Holloway, Simon, Hollyer, Marcus, Holman, Amy, Holmes, Ann, Holmes, Benjamin, Holmes, Megan, Holmes, Raphael, Holmes, Rebecca, Holroyd, Kelly, Holt, Caroline, Holt, Lyndsey, Holt, Siobhan, Holt, Susie, Holyome, Alexandra, Home, Marie, Home, Toni, Homewood, Renate, Hong, Kate, Hontoria del Hoyo, Laura, Hooper, Clare, Hoosdally, Sarah, Hope, Samantha, Hope, Susan, Hopkins, Bridget, Horby, Peter W, Horler, Stephanie, Hormis, Anil, Hornan, Daniel, Hornby, Nicola, Horne, Zoey, Horsford, Latoya, Horsford, Megan, Horsford, Mark, Horsham, Valana, Horsley, Alexander, Horsley, Ashley, Horsley, Elizabeth, Horton, Sarah, Horton-Turner, Nicola, Hosea, Jane, Hoskins, Toby, Hossain, Muhammad S, Hossain, Rashed, Hostler, Leanne, Hough, Maxine, Hough, Sarah, Houghton, Brittany, Houghton, Catherine, Houghton, Iain, Houghton, Kathryn, Houlihan, Rebecca, Houston, Angela, Houston, Hamish, Hove, Tawedzegwa, Hovvels, Roseanna, How, Lee, Howaniec, Laura, Howard, Laura, Howard, Linda, Howard, Lucy, Howard, Sarah, Howard, Stuart, Howard-Griffin, Richard, Howarth, Alison, Howarth, Diane, Howe, Serena, Howells, Mark, Howie, Lyn, Howlett, Kerry, Howlett, Sophie, Hoyle, Joanne, Hrycaiczuk, Josh, Htoon, Naing Zaya, Htwe, Su, Hu, Ying, Huah, Chiang Ooi Huah, Huckle, Abby, Huda, Shahzya, Hudak, Alison, Hudig, Lisa, Hudson, Alex, Hudson, Cara, Hudson, Heather, Hudson, Peter, Hudson, Oli, Hufton, Alison, Huggins, Connor, Hughes, Alistair, Hughes, Eithne, Hughes, Emma, Hughes, Gareth, Hughes, Heather, Hughes, Luke, Hughes, Rachel, Hughes, Rebecca, Hughes, Samantha, Hughes, Stephen, Hughes, Vikki, Hughes, Wesley, Huhn, Lukas, Hui, Ching, Hulbert, Ruth, Hull, Diana, Hull, Grace, Hull, Robert, Hulme, Amanda, Hulme, Peter, Hulse, Wendy, Hulston, George, Hum, Ryan, Humber, Laura, Hume, Megan, Humphrey, Charlotte, Humphreys, Ismay, Humphries, Alasdair, Humphries, Joanne, Hunold, Lena, Hunt, Fiona, Hunt, Kristen, Hunt, Luke, Hunt, Sophie, Hunter, Al, Hunter, Alexandra, Hunter, Isobel, Hunter, Karl, Hunter, Neil, Huntington, George, Hurditch, Elizabeth, Hurley, Cian, Hurley, Katrina, Husain, Mohammed A, Husaini, Syeda Yusra, Huson, Coralie, Hussain, Afreen, Hussain, Ibraar, Hussain, Ifza, Hussain, Mohammad, Hussain, Muhammad, Hussain, Reda, Hussain, Sajid, Hussain, Samia, Hussain, Sanniah, Hussain, Wasim, Hussain, Yasmin, Hussam El-Din, Mohammed, Hussein, Raheem, Hussey, Rebecca, Hutchinson, Camille, Hutchinson, Dorothy, Hutchinson, Elizabeth, Hutchinson, John, Hutsby, Claire, Hutton, Paula, Hydes, Daniella, Hyde-Wyatt, Jamie, Hynes, Niamh, Hyslop, Megan, Ibraheim, Mazen, Ibrahim, Abdalla, Ibrahim, Ahmed, Ibrahim, Asil, Ibrahim, Mohamed, Ibrahim, Monzeer, Ibrahim, Wadah, Idowu, Adetokunbo I, Idrees, Muhammad, Iftikhar, Hina, Iftikhar, Mawara, Igwe, Chukwuemeka, Ijaz, Mohammad, Ikomi, Amaju, Iles, Clare, Iliodromiti, Stamatina, Ilsley, Mary, Ilves, Lorna, Imam-Gutierrez, La'ali, Imray, Christopher, Imtiaz, Alison, Imtiaz, Haider, Ingall, Claire, Ingham, Jack, Ingham, Julie, Ingham, Rory, Ingle, Tejas, Inglis, Jennifer, Ingram, Anne, Ingram, Luke, Inns, Peter, Inweregbu, Ken, Ionescu, Andreea A, Ionita, Ana, Iordanov, Ilian P, Ipe, Anil, Iqbal, Adil, Iqbal, Madiha, Iqbal, Mohammed, Iqbal Sait, Faisal, Ireland, Jane, Irons, Robert, Irshad, Mohannad, Irshad, Muhammad S, Irvine, Janice, Irvine, Val, Irving, Pamela, Irving, Robert, Ishak, Mina, Isherwood, Erica, Islam, Aminul, Islim, Abdurrahman, Ismail, Ali, Ismail, Omar, Ison, Caroline, Israa, M'hamedi, Isralls, Sharon, Issa, Ali, Ivan, Monica, Ivel, Catrina, Ivenso, Chineze, Ivy, Ashleigh, Iwanikiw, Sophie, Ixer, Karen, Iyer, Menaka, Iyer, Mia, Jack, Calum, Jackson, Amanda, Jackson, Anthony, Jackson, Ben, Jackson, Beth, Jackson, Douglas, Jackson, Ella, Jackson, Hayley, Jackson, Helen, Jackson, Jane, Jackson, Julie, Jackson, Karin, Jackson, Lauren, Jackson, Melanie, Jackson, Nicola, Jackson, Shane, Jackson, Sharon, Jacob, Nikita, Jacob, Patricia, Jacob, Reni, Jacques, Nicola, Jacques-Brown, Terri-Lisa, Jafar, Anisa, Jafferji, Daniel, Jaffery, Ali, Jagadish, Chandrashekar, Jagannathan, Vijay, Jaggard, Sam, Jagpal, Mandeep, Jaime, Fernandez R, Jain, Neemisha, Jain, Seema, Jain, Susan, Jaiswal, Sanjay, Jajbhay, Danyal, Jaki, Thomas, Jallow, Bintou, Jaly, Yusuf, Jamal, Sabine, Jamal, Zeba, Jameel, Yasmin, James, Albie, James, Christie, James, Kate, James, Lee, James, Linda, James, Mark, James, Nicholas, James, Olivia, James, Rebecca, James, Ruth, James, Tracy, Jameson, Jack, Jamison, Aaron, Jane, Phoebe, Janmohamed, Azara, Jansz, Sabrina, Japp, Deepa, Jappy, Lorraine, Jardim, Victor, Jardine, Catherine, Jarnell, Emma, Jarvie, Ellie, Jarvis, Ann, Jarvis, Claire, Jarvis, Lisa, Jarvis, Rosina, Jastrzebska, Patrycja, Javed, Hafsa, Jawad, Mays, Jawaheer, Lona, Jawaid, Kauky, Jayachandran, Anu, Jayachandran, Dinakaran, Jayakumar, Angelina, Jayaram, Deepak, Jayaram, Ravi, Jayasekera, Geeshath, Jayatilleke, Thilina, Jayebalan, Abi, Jeddi, Saman, Jeebun, Vandana, Jeelani, Mohammad S, Jeewa, Zeynab, Jefferson, Emma, Jeffery, Katie, Jeffrey, Helen, Jeffrey, Jenni, Jeffrey, Rachel, Jeffrey, Sue, Jeffreys, Nathan, Jeffs, Benjamin, Jegede, Debbie, Jemima, Taylor, Jenkin, Ifan, Jenkins, Alison, Jenkins, Christopher, Jenkins, David, Jenkins, Elinor, Jenkins, Sarah, Jenkins, Sian, Jenkins, Stephen, Jennings, Jacqui, Jennings, Louise, Jennings, Rebecca, Jennings, Virginia, Jerome, Ellen, Jerry, Douglas, Jessup-Dunton, Ellen, Jesus Silva, Jorge Antonio, Jetha, Champa, Jethwa, Kishan, Jeyachandran, Jeby, Jeyakumar, Visuvanathan, Jeyapalan, Dharshana, Jhanji, Shaman, Jian, Khoo, Jiao, Zhixin, Jimenez, Laura, Jimenez Gil, Ana, Jith, Jithin, Joefield, Teishel, Johal, Navraj, Johannessen, Karine, Johari, Aisyah, John, Annie, John, Anu, John, Navin, John, Sarah, Johns, Emma, Johns, Margaret, Johnson, Anne-Marie, Johnson, Antoinette, Johnson, David, Johnson, Emma, Johnson, Gillian, Johnson, Kathryn, Johnson, Katie, Johnson, Luke, Johnson, Mark, Johnson, Nelsonseelan, Johnson, Oliver, Johnson, Rachel, Johnson, Tracy, Johnson, Zoe, Johnston, Claire, Johnston, Janet, Johnston, Laura, Johnston, Susan, Johnston, Victoria, Johnstone, Dawn, Johnstone, Ed, Johnstone, Janet, Joishy, Manohar, Jones, Adam, Jones, Alistair, Jones, Annabel, Jones, Ben, Jones, Bryony, Jones, Carys, Jones, Ceri, Jones, Charlotte, Jones, Christine E, Jones, Debra, Jones, Emily, Jones, Gareth, Jones, Geraldine, Jones, Hazel, Jones, Jac, Jones, James, Jones, Jamie, Jones, Jessica, Jones, Jonathon, Jones, Julie, Jones, Karen, Jones, Kate E, Jones, Kevin, Jones, Laura, Jones, Laura M, Jones, Lorna, Jones, Louise, Jones, Mathew, Jones, Nicola, Jones, Paul, Jones, Rhianna, Jones, Ruth E, Jones, Samantha, Jones, Sophie, Jones, Stefanie, Jones, Steve, Jones, Taya, Jones, Tim, Jones, Tracey, Jonnalagadda, Ramya, Jordache, Rebecca, Jose, Annette, Jose, Sanal, Joseph, Anna, Joseph, Joseph, Joseph, Rosane, Joseph, Sibet, Joshi, Dhaara, Joshi, Mehul, Joshi, Pratichi, Joshi, Revati, Josiah, Benz, Joyce, Tiffany, Ju Wen Kwek, Adriel, Jude, Edward, Judge, Parminder, Juhl, Jessica, Jujjavarapu, Sirisha, Juniper, Mark, Juszczak, Edmund, Jyothish, Deepthi, Kabiru Dawa, Kasamu, Kacar, Mark, Kacinova, Katarina, Kadam, Nikhil, Kahari, Rebecca, Kakoullis, Gail, Kala Bhushan, Azad, Kalayi, Richard JK, Kaliannan Periyasami, Roobala, Kallistrou, Efthymia, Kalsoom, Seika, Kam, Elisa, Kamara, John, Kamara, Mohamed, Kamath, Ajay, Kamath, Prakash, Kamath, Ravindra, Kamerkar, Siddharth Arun, Kametas, Nick, Kamfose, Musaiwale, Kandaswamy, Arul, Kane, Leia, Kankam, Osei, Kannan, Thogulava, Kant, Abhinav, Kapil, Vikas, Kapoor, Ritoo, Kapoor, Sonal, Kar, Sourjya, Kara, Janaka, Kara, Vasita, Karakantza, Marina, Kark, Rona, Karunaratne, Nicholas, Kasianczuk, Natashja, Kasipandian, Vidya, Kassam, Rizwan, Kathirgamachelvam, Janarth, Katsande, Victoria, Kaul, Kulbinder, Kaur, Daljit, Kaur, Dervinder, Kaur, Jasmin, Kaur, Jaspreet, Kaur, Satvinder, Kausar, Zunaira, Kawser, Mohammad AA, Kay, Andrea, Kay, Sarah, Kayappurathu, Jossy N, Kaye, Callum, Kazeem, Ahemd, Kazi, Naved, Kaznica, Sharon, Kearley, Samantha, Kearns, Rachel, Kearsley, Nichola, Keating, Joanne, Keating, John, Keating, Liza, Keddie-Gray, Elizabeth, Keen, Katie, Keenan, Natalie, Kefas, Jonathan, Kegg, Stephen, Keith, Laura, Keke, Uzoamaka, Kelani, Tosin, Kellett, Joanne, Kellington, Jeremy, Kelly, Alison, Kelly, Conor, Kelly, David, Kelly, Diane, Kelly, Dominic, Kelly, Emma, Kelly, Laura, Kelly, Martin, Kelly, Michael, Kelly, Rosalind, Kelly, Sinead, Kelly, Stephen, Kelly, Thomas, Kelly-Baxter, Mary, Keltos, Marketa, Kemp, Timothy, Kemsley, Kelly, Kendall-Smith, Alexandra, Kennard, Sarah, Kennedy, Ann, Kennedy, Caroline, Kennedy, James, Kennedy-Hay, Sophie, Kenny, Julia, Kent, Kelly, Kent, Melanie, Keogan, Lynne, Keough, Alexander, Kerlin, Clement, Kerr, A, Kerr, Andrew, Kerr, Maria, Kerrison, Caroline, Kerry, Anthony, Kershaw, Samantha, Kerslake, Helen, Kerslake, Ian, Kerss, Helen, Keshet-Price, Jocelyn, Kevern, Margaret, Keyte, Georgina, Khadar, Abdul, Khalid, Ali, Khalid, Muhammad U, Khalid, Syed, Khalil, Amir, Khalil, Asma, Khalil, Sijjad, Khan, Abubakar, Khan, Ali, Khan, Al-Imran, Khan, Arham, Khan, Asad, Khan, Aurangzeb, Khan, Burhan, Khan, Camran, Khan, Fatimah, Khan, Kausik, Khan, Malik Aamaz, Khan, Marria, Khan, Mehrunnisha, Khan, Mohammad, Khan, Mohammed, Khan, Nayeem, Khan, Omar, Khan, Rahe, Khan, Rahila, Khan, Sabiya, Khan, Shabana, Khan, Shahul, Khan, Shoaib, Khan, Tasaduksultan, Khan, Waseem, Khatana, Usman F, Khatri, Jibran, Khatri, Jyoti, Khatun, Hafiza, Khatun, Taslima, Kheia, Mena, Khera, Jacyntha, Khin, Htet Ei, Khoja, Najaf, Khokhar, Kiran, Khorsandi, Jayne, Khurana, Chloe, Kibutu, Faith, Kidd, Andrew, Kidd, Michelle, Kidney, Joe, Kidney, Shane, Kieffer, Will, Kilbane, James, Kilby, Caroline, Killen, Eileen, Kilroy, Susan, Kim, Bomee, Kim, Jee Whang, Kimber, Sarah, King, Andy, King, Barbara, King, Jennifer, King, Kirsten, King, Rachel, King, Sarah, King, Tony, King, Victoria, King-Oakley, Emily, Kingsmore, Laura, King-Venables, Andy, Kinney, Fiona, Kiran, Sidra, Kirk, Jeremy, Kirk, Jodie, Kirkbride, Daniel, Kirkby, Amy, Kirker, Ian, Kirkham, Emily, Kirkman, Gemma, Kirwan, Ursula, Kislingbury, Kelly, Kitching, Toby, Kitto, Laura, Kittridge, Lauren, Klaczek, Sarah, Kleemann, Frieder, Kmachia, Susan, Knapp, Chris, Knibbs, Lucy, Knight, Alicia, Knight, Fraser, Knight, Marian, Knight, Sarah, Knight, Steven, Knight, Tom, Knights, Ellen, Knights, Jane, Knights, Toby, Knolle, Martin, Knott, Carol, Knowles, Charlotte, Knowles, Karen, Knowles, Laurence, Knox, Emily, Knox, Lucy, Koch, Oliver, Kodituwakku, Ronan, Koduri, Gouri, Koirata, Aisha, Kolakaluri, Eirene, Kolodziej, Magdalena, Kolokouri, Eirini, Kolsteren, Keith, Kon, Samantha, Konar, Niladri, Kononen, Mari, Konstantinidis, Athanasios, Koo, Hui Fen, Koopmans, Imogen, Kopyj, Emmanuela, Korcierz, Laura, Korolewicz, James, Koshy, George, Kosmidis, Chris, Kotecha, Jalpa, Kothandaraman, Easwari, Koukouflis, Leonidas, Kouranloo, Koushan, Kousar'c, Rukhsana, Kousteni, Margarita, Kovac, Maja, Kozak Eskenazia, Alex, Krasauskas, Kestutis, Krishnamurthy, Raghu, Krishnamurthy, Vinodh, Krishnan, Manju, Krishnan, Hari, Krizak, Suzanne, Krupej, Sean, Kubisz-Pudelko, Agnieszka, Kudsk-Iversen, Soren, Kudzinskas, Aurimas, Kukadiya, Chirag, Kulkarni, Nainesha, Kumar, Aditi, Kumar, Mayur, Kumar, Ramesh, Kumar, Ravi, Kumar, Rita, Kumar, Rupa, Kumar, Satish, Kumar, Vimal, Kundu, Arun, Kunst, Heinke, Kurani, Amit, Kurdy, Mohammed, Kurian, Rincy, Kurmars, Vimal, Kuronen-Stewart, Cameron, Kusangaya, Ranganai S, Kushakovsky, Vlad, Kuunal, Mandy, Kuverji, Apexa, Kyei-Mensah, Amma, Kyere-Diabour, Thyra, Kyi, Moe, Kyi, Nyan M, Kyle, Laura, Kyriaki, Karali-Tsilimpari, Labao, Julius, Lacey, Louise, Lack, Nikki, Ladlow, Emma, Lafferty, Heather, Laha, Shondipon, Lahane, Sushil, Lai, Clement, Lai, James, Laing, Emma, Laing, Robert, Laing-Faiers, Inez, Laity, Emily, Lake, Michelle, Lakeman, Nicki, Lalloo, David, Lalloo, Fiona, Lam, Alison, Lamb, Fiona, Lamb, Lucy, Lamb, Thomas, Lambe, Nick, Lambert, Pauline, Lameirinhas, Claudia, Lami, Mohammed KG, Lamikanra, Abigail, Lamont, Holly, Lamparski, Michal, Lamrani, Djillali, Lanaghan, Christine, Lanaway, Rebecca, Lancona-Malcolm, Ivone, Lancut, Julia, Landers, Geraldine, Landray, Martin J, Lane, Matthew, Lane, Nicholas, Lang, Alidih, Lang, Stephen, Langer, Daniel, Langley, Margaret, Langoya, Charles, Langthorne, Emily, Large, Taiya, Lason, Wojciech, Last, Anna, Latham, Scott, Latham-Mollart, John, Latheef, Afzal, Latimer, Darren, Latt, Nang, Lattimore, Carly-Jane, Lau, Dawn, Lau, Eva, Laurenson, Myra, Law, Hou, Law, Jennifer, Law, Jessica, Law, Penny, Law, Richard, Lawler, Colin, Lawley, Mark, Lawrence, Emma, Lawrence, Jo, Lawrence, Neil, Lawrie, Ryan, Lawson, Jemima, Lawson, Joanne, Lawson, Louise, Lawton, Rebecca, Lay, Michael, Laycock, Christine, Layug, Reina, Lazo, Maria, Le, Vietland, Lea, Amelia, Lea, William, Leadbitter, Ian, Leahy, Thomas, Lean, Richard, Leandro, Lorna, Leaning, Darren, Leason, Sandra, Leaver, Christina, Ledingham, Marie Anne, Lee, Emma, Lee, Hannah, Lee, Irish, Lee, Judith, Lee, Sam, Lee, Shi Han, Lee, Simon, Lee, Sindy, Lee, Stephanie, Lee, Tracey, Lee, Xiang, Lees, Diana, Lees, Jennifer, Legge, Helen, Leggett, Julian, Leigh-Ellis, Katie, Leighton, Kevan, Leitch, Nicky, Lekoudis, Eleni, Lemessy, Petula, Lemoine, Nicholas, Lemos, Joana, Lenchuk, Irina, Leng, Katy, Lennon, Katrina, Lennon, Liz, Lentell, Isabel, Leonard, Kelly, Leong, Wen, Leopold, Nicky, Lepiarczyk, Oskar, Leslie, Isla, Lester, Eleni, Leung, Joe, Leuschner, Ullrich, Levell, Emma, Levett, Chris, Lewin, Alice, Lewin, Michaela, Lewis, Alison, Lewis, David, Lewis, Dee, Lewis, Georgina, Lewis, Gillian, Lewis, Joanne, Lewis, Joseph, Lewis, Kathryn, Lewis, Keir, Lewis, Leon, Lewis, Lisa, Lewis, Marissa, Lewis, Rob, Lewis, Robert, Lewis-Clarke, Catherine, Lewis-Prosser, Lorraine, Lewiston, Katherine, Lewszuk, Adam, Lewthwaite, Penny, Ley, Samantha, Li, Anna, Li, Jenny, Liao, Angela, Licence, Victoria, Lieberman, David, Liebeschuetz, Susan, Lightfoot, Nicky, Lillie, Patrick, Lim, Ben, Lim, Carys, Lim, Ee Thong, Lim, Ivy, Lim, Terence, Lim, Wei Shen, Lim, Wilson, Limb, James, Limbu, Usha, Linares, Christian, Linden, Dermot, Lindergard, Gabriella, Lindley, Kate, Lindsay, Charlotte, Lindsay, Emily, Lindsay, Max, Lindsay-Clarke, Helen, Ling, Mirella, Lingam, Claire, Linkson, Linette, Linney, Mike, Linsell, Louise, Lippold, Conrad, Lipscomb, George, Lipscomb, Karen, Lipskis, Laura, Lisboa, Ana, Lister, Evangeline, Little, Charlotte, Little, Jeff, Little, Sam, Liu, Xuedi, Liversidge, Alexandra, Livingstone, Jill, Llanera, Daniel K, Llewellyn, Rhiannon, Llewelyn, Martin, Lloyd, Adam, Lloyd, Aimee, Lloyd, Arwel, Lloyd, Oliver, Lloyd, Richard, Lo, Su, Loader, David, Lobato, Cristina, Lobo-Clarke, Maria, Lock, Lydianne, Lock, Sara, Lock, Stephen, Locke, Angela, Locke, Jacqueline, Locke, Thomas, Lockett, Teresa, Lockyer, Sandy, Lodge, Jeorghino, Lodge, Terrence, Lofthouse, Martina, Lofting, Tracey, Loftus, Heather, Logan, Meg, Logue, Chloe, Loh, Sook Yin, Lokanathan, Siddharth, Lomme, Kaatje, London, Emily, Long, Gabriella, Long, Natalie, Longhurst, Bev, Longshaw, Mark, Lonnen, Jennifer, Lonsdale, Caroline, Looby, Laura, Loosley, Ronda, Lopez, Paola, Lopez, Paula, Lord, Robert, Lord, Stuart, Lordache, Laura, Loregnard, Kieron, Lorenzen, Catherine, Lorimer, Claire, Loro, Francesco, Lorusso, Rachel, Loutraris, Eva, Loveless, Robert, Lovell, Maxine, Loverdou, Angeliki, Lovett, Huw, Loveys, Daniel, Low, Andrew, Low, Jen Mae, Lowe, Alastair, Lowe, Caroline, Lowe, Catherine, Lowe, Emily, Lowe, Faye, Lowe, Michael, Lowrey, Linda, Lowsby, Richard, Lowthorpe, Vicki, Loxley, Emma, Lubimbi, Gamu, Lubina Solomon, Alexandra, Lucas, Georgia, Lucas, Jacob, Lucey, Alice, Lucey, Olivia, Luck, Suzanne, Luke, H, Luke, Jane, Lund, Hayley, Lunia, Apurva, Lunn, Muriel, Luo, Ji, Lussier, Julia, Luximon, Cindy Nisha, Ly, Elisa, Lyell, Barrie, Lyka, Elisavet, Lymn, Sarah, Lynas, Audrey, Lynch, Ceri, Lynch, Daniel, Lynch, Daniella, Lynch, Stephen, Lyon, Helen, Maamari, Rea-Grace, Mabb, Hannah, Mabelin, Louies, Macaro, Jessica, Macauley, Angela, Macconaill, Kateryna, Macdonald, Chloe, MacDonald, Stuart, MacDonald, Tania, Macfadyen, Claire, Macfarlane, James G, Macfarlane, Jill, Macfarlane, Laura, MacGuigan, Cara, MacInnes, Lisa, MacIntyre, Iain, MacIntyre, Jill, Mack, Kirsten, Mackay, Callum, Mackay, Euan, Mackay, Laura, Mackenzie, Alexander, Mackenzie, Matt, MacKenzie Ross, Robert, Mackey, Ami, Mackey, Patricia, Mackie, Fiona, Mackie, Robert, Mackinlay, Carolyn, Mackintosh, Claire, Mackintosh, Katherine, MacLennan, Sheila, MacLeod, Mary Joan, Macmahon, Michael, MacNair, Andrew, Macphee, Catherine, Macpherson, Iain, Macrae, Catriona, MacRaild, Allan, MacVean, Eilidh, Madden, Alannah, Madden, Mary, Madeja, Norman, Madgwick, Karen, Madhivathanan, Pradeep, Madhusudhana, Madhavi, Madiyiko, Harriet, Madu, Alpha, Madziva, Lorraine, Mafham, Marion, Magee, Nick, Magezi, Frederick, Maggs, Tim, Maghsoodi, Negar, Magier, Christopher, Magriplis, Marios, Maguire, Kathryn, Mahabir, Natasha, Mahadevan-Bava, Subramanian, Maharajh, Anjanie, Mahaveer, Ajit, Mahay, Bal, Mahay, Kanta, Mahdi, Hibo, Mahendiran, Thushika, Mahendran, Siva, Maher, Sarah, Maheswaran, Anistta, Maheswaran, Shameera, Maheswaran, Tina, Mahjoob-Afag, Parisa, Mahmood, Ahmed, Mahmood, Farhana, Mahmood, Waheed, Mahmood, Zahra, Mahmoud, Hager, Mahony, Ewan, Mair, Luke, Majekdunmi, Toluwani, Majid, Kesson, Major, Rupert, Majumdar, Jaydip, Majumder, Mohammad KH, Makin, Stephen, Malanca, Marius, Malcolm, Hannah, Malein, Flora, Malhan, Neeraj, Malik, Ayesha, Malik, Gulshan, Maljk, Mohammed, Mallett, Paul, Mallinder, Petrina, Mallison, Georgia, Mallon, Louise, Malone, Edward, Maloney, Gracie, Malundas, Edgar, Mamman, Madhu, Man, Irene, Man, Kathy, Mancinelli, Rossana, Mancuso-Marcello, Marco, Manders, Tracy, Manderson, Lauren, Mandeville, Justin, Manhas, Roope, Maniero, Carmen, Manikonda, Ravi, Mann, Bobby, Manning, Jonathan, Mannion, Lynne, Mansi, Katherine, Manso, Katarina, Mansour, Dina, Mapfunde, Isheunesu T, Mappa, Predeesh, Maraj, Hemant, Marange, Garikayi, March, Lisa, Marchand, Clare, Marcus, Neil, Marecka, Maria, Margabanthu, Gomathi, Margalef, Jordi, Margarit, Lavinia, Margaritopoulos, Georgios, Margarson, Mike, Maria del Rocio, Fernandez M, Maria Pfyl, Teresa, Mariano, Victor, Maria-Osborn, Helen, Maric, Ashleigh, Markham, Grace, Markham, John, Marks, Maria, Marks, Pamela, Marouzet, Elisabeth, Marriott, Arran, Marriott, Cheryl, Marriott, Nemonie, Marsden, Brian, Marsden, Karen, Marsden, Paul, Marsden, Sarah, Marsden, Tracy, Marsh, Robyn, Marshall, Adam, Marshall, Andrew, Marshall, Gail, Marshall, Henry, Marshall, Jaimie, Marshall, James, Marshall, Jenna, Marshall, Nicola, Marshall, Riley, Marshall, Jennifer, Marston, Samantha, Martin, Emmeline, Martin, Hayley, Martin, Hope, Martin, Jane, Martin, Karen, Martin, Kate, Martin, Laila, Martin, Michael, Martin, Noelia, Martin, Tim, Martin, Winston, Martin, Sarah, Martindale, Tim, Martineau, Marcus, Martinez, Alexander, Martinez, Lauren, Martinez Garrido, Jose Carlos, Martin-Lazaro, Juan, Martins, Olivia, Martins Ferreira, Lucas, Maruthamuthu, Vijay Kumar, Maryan, Gemma, Mary-Genetu, Roman, Maryosh, Sam, Masani, Vidan, Maseda, Diego, Mashate, Sheila, Mashhoudi, Yasaman, Mashta, Al, Masih, Izhaq, Masih, Sanna, Maskell, Nick, Maskell, Perry, Masoli, Matthew, Mason, Lynn, Mason, Rebecca, Mason, Richard, Mason, Ruth, Mason, Claire, Masood, Mohammad, Masood, Mohammad T, Masood, Syed, Masood, Syed SME, Masud, Aaqib, Matapure, Lear, Matei, Cristina, Matewe, Ropafadzo, Matharu, Manraj, Mathen, Stephy, Mather, Alex, Mather, Nicole, Mathers, Jonathan, Matheson, Joanna, Mathew, Amal, Mathew, Anna, Mathew, Moncy, Mathew, Verghese, Mathews, Caroline, Mathews, Jesha, Mathias, Kate, Mathie, Marion, Matila, Darwin, Matimba-Mupaya, Wadzanai, Matin, Nashaba, Matisa, Elina, Matonhodze, Max, Matovu, Elijah, Mattappillil, Jaysankar, Matthews, Alison J, Matthews, Heather, Matthews, Helen, Matthews, Sue, Matthias, Gwynn, Maxton, Fiona, Maxwell, Adam, Maxwell, Gemma, Maxwell, Veronica, May, James, May, Joanne, May, Oliver, May, Philippa, Mayanagao, Irving, Maycock, Matthew, Mayers, Graham, Maynard, Lee, Mayor, Shelley, Mazen, Ibreaheim, Mazzella, Andrea, Mburu, Nyambura, Mbwembwe, Mercy, McAdam, Martyn, McAleese, Eleanor, McAleese, Helinor, McAlinden, Paul, McAlpine, Audrey, McAlpine, Graeme, McAndrew, Jonathan, McAuley, Hamish, McAuliffe, Sarah, McBrearty, Claire, McBride, Carole, McBride, Erin, McBuigan, Michael, McBurney, James, McCabe, Laura, McCairn, Amanda, McCalmont, Martina, McCammon, Jake, McCammon, Nicole, McCann, Conor, McCarrick, Alexandra, McCarron, Brendan, McCarthy, Eoghan, McCarthy, Michelle, McCarthy, Natalie, McCaughey, Sinead, McChlery, Gareth, McClay, Tara, McClelland, Beverley, McClintock, Declan, McCormack, Patricia, McCormick, Jacqueline, McCormick, Wendy, McCourt, Paul, McCrae, Jame, McCready, Sharon, McCreath, Allison, McCreath, Gordan, McCreedy, Helen, McCreery, Louise, McCullagh, Iain J, McCullagh, Josephine, McCullagh, Liz, McCullagh, Megan, McCullough, Conor, McCullough, Katherine, McCullough, Nicola, McCullough, Sarah, McCurrach, Fiona, McDermott, Rory, McDevitt, Katharine, McDill, Helen, McDonald, Basil, McDonald, Claire, McDonald, Debbie, McDonald, Rob, McDonald, Sam, McDonald, Damhnaic, McDougall, Rowan, McEleavy, Irene, McEnerney, Julie, McEntee, Julie, McEvoy, Evanna, McEwen, Ruth, McFadden, Margaret, McFarland, Denise, McFarland, Margaret, McFarland, Rachel, McGarry, Erin, McGarvey, Lorcan, McGarvey, Margaret, McGettigan, Clodagh, McGettrick, Michael, McGhee, Christopher, McGill, Fiona, McGinnity, Sarah, McGivern, Hannah, McGlinchey, Neil, McGlone, Phil, McGlynn, Deborah, McGoldrick, Claire, McGoldrick, Clare, McGough, Elizabeth, McGovern, Margaret, McGrath, Brendan, McGregor, Amanda, McGregor, Annemarie, McGuinness, Cathryn, McGuinness, Heather, McGuire, Sean, McHugh, Tara, McInnes, Caroline, McInnes, Neil, McIntyre, Karen, McIntyre, Mhairi, McKay, Carolyn, McKay, Lorna, McKeag, Conor P, McKee, Madeleine, McKeever, Joseph, McKenna, Shirley, McKeogh, Donogh, Mckeown, Denise, McKerr, Caroline, McKie, Anthony M, Mckie, Claire, Mckie, Laura, McKnight, Gerard, McLachlan, Heather, McLaren, Andrew, McLaren, Barbara, McLarty, Nicola, McLaughlin, Maria, McLay, James, McLeish, Mary, McLennan, Tina, McLintock, Lorna, McLure, Stewart, McMahon, Amanda, McMahon, Anne Marie, McMahon, Genevieve, McMahon, Joanne, McMahon, Mike, McMahon, Stephen, McManus, Terence, McMaster, Moyra, McMaster, Paddy, McMeekin, Samuel, McMillan, Nicola, McMinn, Jason, McMorrow, Liam, McNally, Helen, McNamara, Darren, Mcnamara, Helen, McNaughton, Deborah, McNeela, Fiona, McNeil, Lynne, McNeill, Claire, McNeill, Shea, McNelis, Una, McNicholl, Mary P, McNulty, Melanie, McNulty, Roisin, McParland, Christopher, McPhail, Mark, McQueen, Alison, McSkeane, Anna, McSorland, Denise, McTaggart, Gini, McTaggart, Jacqueline, McWilliam, Sam, Mead, Joanna, Mead, Karen, Meadows, Emma, Meakin, Olivia, Mearns, Ben, Mearns, Claire, Mears, Kim, Mears, William, Meda, Manjula, Mediana, Ayren, Medine, Ross, Medveczky, Thomas, Meehan, Sharon, Meek, Matthew, Meeks, Emily, Meess, Anke, Megan, Abbi, Meghani, Nevan, Meghjee, Salim, Mehew, Jenny, Mehra, Rohan, Meier, Jana, Meiring, James, Mejri, Rayane, Melander, Sabina, Melinte, Adriana-Stefania, Mellin, Stephanie, Mellor, Francesca, Mellor, Phil, Mellor, Samantha, Mellor, Zoe, Mellows, Katrina, Melnic, Vladimir, Melville, Alice, Melville, Julie, Membrey, Helen, Mencias, Mark, Mendonca, Cheryl, Mentzer, Alexander, Menzies, Dan, Mepham, Sue, Mercer, Oliver, Mercer, Pauline, Merchant, Arwa, Merchant, Fatema, Mercioniu, Mihaela, Meredith, Megan, Merida Morillas, Marta, Merrick, Blair, Merritt, Jack, Merritt, Simon, Merwaha, Ekta, Message, Simon, Metcalf-Cuenca, Gabriel, Metcalfe, Benjamin, Metcalfe, Kneale, Metherell, Stella, Methven, Greg, Metryka, Alexsandra, Mew, Louise, Meyrick, Simon, Mguni, Nhlanhla, Miah, Atiqa, Miah, Jagrul, Miah, Nahima, Mic, Gabriela, Micallef, Dariush, Michael, Alice, Michael, Angiy, Michael, Shery, Michael, Vincent, Michalak, Natalia, Michalca-Mason, Loredana, Michelson, Claire, Middle, Janet, Middleton, Hayley, Middleton, Jennifer T, Middleton, Maeve, Middleton, Sophie, Mieres, Shelley, Miflin, Gail, Mihalca-Mason, Loredana, Mikolasch, Theresia, Milgate, Sarah, Millar, Colin, Millar, Ian, Millar, Jonathan, Miller, David, Miller, Johnathan, Miller, Lucy, Miller, Rachel, Miller-Biot, Naomi, Miller-Fik, Alex, Millett, Louise, Milligan, Hazel, Milligan, Iain, Milliken, Caitlin, Millington, Katherine, Millington, Samuel, Milloy, Melanie, Mills, Helen, Mills, Janet, Mills, Steve, Millward, Helen, Miln, Rebecca, Milne, Alice, Milne, Charlotte, Milne, Louise, Milner, Joanne, Min, Zayar, Mindel, Samuel, Minhas, Arron, Minnis, Chrissie, Minnis, Paul, Minogue, Anne, Minton, Jane, Miranda, Frederico, Mires, Lucy, Mirza, Taimur, Misbahuddin, Anjum, Mishra, Aseem, Mishra, Biswa, Mishra, Eleanor, Mishra, Ritu, Misra, Sannidhya, Mistry, Deena, Mistry, Heena, Mistry, Nita, Mistry, Reena, Mital, Dushyant, Mitchard, Sarah, Mitchell, Alan, Mitchell, Ben, Mitchell, Piers, Mitchell, Susan, Mitchelmore, Philip, Mitra, Andrew, Mitra, Atideb, Mitra, Sandip, Mizzi, Clarisse, Mmadubuko, Gloria, Moakes, Emma, Moatt, Emma, Modgil, Gita, Mohamed, Abdelrahman, Mohamed, Arez, Mohamed, Osab, Mohammad, Waheed, Mohammed, Aliabdulla, Mohammed, Omer, Mohammed, Yaser NS, Mohamud, Bilal A, Mohan, Mahalakshmi, Moharram, Amr, Moir, Rachel, Mok, Jonathan, Moller-Christensen, Christine, Mollet, Mateus, Molloholli, Malid, Molloy, Aoife, Molloy, April, Molloy, Linda, Molyneux, Andrew, Momoniat, Tasnim, Monaghan, Holly, Monaghan, Josephine, Monaghan, Krista, Mongolu, Shiva, Monsell, Katelyn, Montasser, Mahmoud, Montgomery, Alan, Montgomery, Hugh, Moodley, Prebashan, Moody, Ian, Moody, Margaret, Moody, Nick, Moon, Angela, Moon, James, Moon, Ji-Hye, Moon, Maria, Moonan, May, Moondi, Parvez, Moore, Alex, Moore, Carly, Moore, Christopher, Moore, Davidjar, Moore, Faye, Moore, Gillian, Moore, Hannah, Moore, Judith, Moore, Laura, Moore, Sally, Moore, Sonia, Moore, Tracy, Moores, Rachel, Morab, Ed, Morales, Jose, Moramorell, Nuria, Moran, Louise, Moray, Grishma, Moreno-Cuesta, Jeronimo, Morgan, Adam, Morgan, Amy, Morgan, Christine, Morgan, Colin, Morgan, Jackie, Morgan, Lauren, Morgan, Leila, Morgan, Matthew, Morgan, Patrick, Morgan-Jones, Katie, Morgan-Smith, Emily, Morley, Anna, Morley, Thomas, Morley, Wendy, Morris, Anna, Morris, Damian, Morris, Fiona, Morris, Helen, Morris, Juliet, Morris, Katie, Morris, Laura, Morris, Lucy, Morris, Mary-Anne, Morris, Niall, Morris, Paul, Morris, Sheila, Morris, Susan, Morrison, Douglas, Morrison, Moira, Morrissey, Mary, Morrow, Anna, Morrrell, Chantal, Morselli, Franca, Mortem, Gordon, Morton, Chelsea, Morton, Gordon, Mortuza, Rosna, Morzaria, Priti, Moss, Alison, Moss, Charlotte, Moss, Rachel, Moss, Sarah, Moss, Stuart, Motherwell, Nicki, Mouland, Johanna, Moulds, Caroline, Moulton, Hilary, Mounsey, Lorraine, Mousley, Elizabeth, Moxham, Karen, Moya, Borja, Moyo, Quberkani, Mshengu, Eunice, Mtuwa, Sheila, Muazzam, Ali, Muazzam, Iqtedar A, Muchenje, Nykki, Mudawi, Dalia, Muddegowda, Girish, Mugal, Imran, Mughal, Ahsan, Muglu, Javaid, Muhammad, Javed, Muir, Alison, Muir, Carol, Muir, Martin, Mukherjee, Dipak, Mukhtar, Syed Asim Ali, Mukimbiri, Denise, Mukwa, Tshinupay, Mulgrew, Peter, Mulhearn, Ben, Mulla, Arafat, Mullan, Dee, Mullasseril Kutten, Dileepkumar, Mullen, Niall, Mullett, Rosemary, Mulligan, Sandra, Mullin, Barbara, Mullings, Joanne, Mumelj, Lana, Mumford, Andrew, Mumford, Sarah, Munavvar, Mohammed, Munby, Henry, Munro, Anne-Marie, Munt, Sheila, Munu, Nafissah, Mupudzi, McDonald, Murad, Arshid, Muraina, Oluwatosin H, Muralidhara, Koteshwara, Murdoch, Diane, Murdoch, Mhairi, Murira, Jennifer, Murphy, Alison, Murphy, Carl, Murphy, Emily, Murphy, Fidelma, Murphy, Gail, Murphy, Jo, Murphy, Peter, Murphy, Sheenagh, Murphy, Simon, Murray, Clare, Murray, David, Murray, Eleanor, Murray, Katie, Murray, Kenneth, Murray, Lisa, Murray, Lorna, Murray, Tracey, Murtagh, Eoin, Murthy, Mithun, Murton, Catherine, Murton, Rosie, Muru, Neeka, Musanhu, Rosemary, Mushabe, Maimuna, Mushtaq, Kaiser, Mushtaq, Omaisa, Mustafa, Ahmed M, Mustafa, Elhaytham, Mustafa, Mustafa, Mustapha, Ibrahim, Mustufvi, Zhain, Mutch, Callum, Mutema, Eric, Muthukrishnan, Balakumar, Mutton, Sheree, Muzengi, Natasha, Mwadeyi, Memory, Mwale, Bettina, Mwaura, Esther, Myagerimath, Raji, Myers, Alice, Myers, Sam, Myint, Khin Swe, Myint, Yadee, Myslivecek, Libor, Nabakka, Helen, Nadar, Evelyn, Nadeem, Iftikhar, Nadheem, Moosa, Naeem, Asma, Naeem, Hassan, Naeem, Salman, Nafees, Samraiz, Nafei, Mohamed, Naga, Parminder, Nagarajan, Thapas, Nagra, Imrun, Nagra, Deepak, Naguib, Mina, Naguleswaran, Kirushthiga, Nagumantry, K Shonit, Naicker, Kevin, Naidoo, Sarveshni, Naik, Gireesha, Naik, Rishi, Naik, Samir, Nair, Devu S, Nair, Rajiv, Nair, Tanushree, Naisbitt, Jay, Naismith, Kerry, Nallapareddy, Sri, Nallapeta, Soum, Nallasivan, Arumugan, Nanda, Uttam, Nandani, Aarti, Naqvi, Ali Raza, Naqvi, Asadullah, Naqvi, Sara, Narayan, Shruthi, Nasa, Sophia, Nash, Dominic, Nasheed, Nader, Nasimudeen, Abdul, Nasir, Umer, Nassari, Marwan, Nasser, Tahir, Natajaran, Anushka, Natarajan, Anuja, Natarajan, Geetha, Natarajan, Nalin, Natarajan, Nikhila, Natarajan, Rajkumar, Nathaniel, Noel, Nathvani, Mala, Nathwani, Priyan, Nava, George, Navaneetham, Neena, Navaratnam, Jeya, Navarra, Helen, Naveed, Sadaf, Navin, John, Nawaz, Khuteja, Nawaz, Sarfaraz, Nawaz, Shasta, Nayar, Bonilla, Naylor, Suzanne, Nayyar, Moez, Naz, Farrah, Naz, Mobeena, Nazarali, Salima, Nazari, Babak, Nazir, S, Nazir, Sehar, Ncomanzi, Dumisani, Ndefo, Onyine, Neal, Alan, Neary, Elaine, Negmeldin, Mostafa, Neill, Paula, Neils, Hector E, Nejad, Avideah, Nel, Louise, Nelson, Marie, Nelson, Richard, Nelson, Scott, Nemane, Rajesh, Nepal, Samiksha, Nethercott, Daniel, Netherton, Kimberley, Nettleton, Kimberley, Neville, Claire-Michelle, Nevin, Tracy, Newanji, Josephine, Newby, Alison, Newby, Angela, Newby, David, Newcombe, Tracy, Newman, Charlotte, Newman, Diana, Newman, Julie, Newman, Oscar, Newman, Richard, Newman, Tabitha, Newman, Thomas, Newport, Rachel, Newsam, Claire, Newson, Christopher, Newton, Maria, Ng, Anthony YKC, Ng, Ka Wing, Ng, Maxine, Ng, Sarah, Ng, Wee Jin, Ngan, Thomas, Ngui, Gabriel CE, Ngumo, Alice, Nic Fhogartaigh, Caoimhe, Nicholas, Nathalie, Nicholas, Philip, Nicholas, Rachel, Nicholas, Teresa, Nicholls, Donna, Nicholls, Lisa, Nicholson, Alice, Nicholson, Anne, Nicholson, Annette, Nicholson, Janet, Nickson, Ian, Nicol, Eileen, Nicol, Elizabeth, Nicol, Rebecca, Nicola, Pantelis, Nicoll, Antony, Nikolaos, Pantzaris, Nikonovich, Georgii, Nilsson, Annette, Nimako, Kofi, Nimako, Louise, Nimmo, Camus, Ninan, Preethy, Nirmalan, Mahesh, Nisar, Muhammad, Nisbett, Toby, Nisha James, Aksinya, Nishat, Sabaahat, Nishiyama, Tomoko, Nix, Sara, Nixon, Jennifer, Nixon, Maxine, Nizam Ud Din, Khwaja, Nizami, Maria, Nnadi, Josephine, Noba, Lyrics, Noble, Harriet, Noe, Hsu, Nolan, Jerry, Noor, Zahid, Noori, Zaid, Norgrave, Jamie, Norman, Louis, Norman, Rachel, Norris, Karen, Norris, Lillian, Nortcliffe, Sally Ann, North, Fiona, North, Julie, North, Thomas, Northcote, Julie, Northfield, John, Northover, Samantha, Nortje, Jurgens, Norton, Donna, Norton, Rowen, Notman, Holly, Nourein, Khalid, Novak, Timea, Noyce, Tony, Noyon, Alan, Nubi, Arlene, Nugdallah, Mohamed, Nugent, Anne Marie, Nugent, Justine, Nundlall, Kribashnie, Nunn, Kieran, Nunn, Michelle, Nunnick, Jane, Nupa, Yvonne, Nurgat, Zubeir, Nwankiti, Kelly, Nweje, Eugenia, Nyamugunduru, Godfrey, Nyirenda, Maggie, Nyland, Kerry, O Shea, Daire, O'Donnell, Ruth, O'Hara, Chloe, O'Reilly, Kevin, O'Rourke, William, Oakley, Caroline, Obale, Begho, Oboh, Clements, O'Brien, Andrew, O'Brien, Clare, O'Brien, Julie, O'Brien, Kirsty, O'Brien, Linda, O'Brien, Marese, O'Brien, Neale, O'Brien, Rachel, O'Brien, Sarah, O'Brien, Tracey, O'Bryan, Emma, Obukofe, Ross, O'Callaghan, Christopher, O'Connell, Lorcan, O'Connell, Maria, OConnor, Tadg, O'Connor, Chris, O'Connor, Grainne, Odam, Miranda, Oddie, Sam, Oddy, Sharon, O'Dea, Rosie, Odedina, Yejide, Odedra, Krishma, Odelberg, Sven W, Odell, Natasha, Oderinde, Omolola, Odone, Jessica, O'Donovan, Catherine, Odumeru, Dapo, O'Farrell, Stephen, Offord, Pamela, Ogbara, Tanwa, Ogilvie, Catherine, O'Gorman, Ciaran, Ogunkeye, Oluwatomilola, Ohia, Udeme, Ohja, Shinjali, Ojo, Ohiowele, O'Kane, Mark, Okeke, Tolu, OKell, Eleanor, Okines, Alicia, Okpala, Iheoma, Okpo, Ernest, Okubanjo, Maryanne, Okyne-Turkson, Ché, Olaiya, Raphael, Old, Tim, Oldham, Jane, Oleszkiewicz, Gregory, Oliveira, Marta, Oliver, Annie, Oliver, Catherine, Oliver, Jesse, Oliver, Martyn, Oliver, Zoe, Olokoto, Nurudeen O, Olonipile, Folusho, Olufuwa, Olumide, Olukoya, Olatomiwa, Oluwole-Ojo, Akinlolu, O'Malley, Laura, Omar, Maryam, Omar, Zohra, Omer, Nimca, Omojola, Abi, Omuco, Helen, O'Neill, Bronagh, O'Neill, Connaire, O'Neill, Lauran, Ong, Chon Sum, Onyeagor, Chidera, Ooi, Huah C, Oomatia, Amin, Opena, Maria, Oram, Richard, Orchard, Chloe, Ord, Christy, Ord, Jonathan, O'Reilly, Charlotte, Orekoya, Lola, O'Riordan, Devaki, O'Riordan, Sean, Orme, Amy, Orme, Hannah, Ormrod, Dave, Orr, Charlotte, Orr, Sarah, Orton, Christopher, Osadcow, Anna, Osagie, Rawlings, Osanlou, Rostam, Osborne, Lynn, Osborne, Nigel, Osborne, Rebecca, Osborne, Wendy, Osborne, William, Osbourne, Charles, Osei-Bobie, Jennifer, O'Shea, Mandy, Osman, Joseph, Osman, Wa'el, Osman, Bashir, Osoata, G, Ostermann, Marlies, O'Sullivan, Eoin, O'Sullivan, Susan, Otey, Noor, Otite, Otheroro K., O'Toole, Marie, Outten, Natalie, Owen, Rachel, Owen, Stephanie, Owens, Emma, Owens, Susan, Owoseni, Yetunde, Owston, Michael, Oxlade, Ruth, Ozdes, Feray, Pack, Jamie, Packham, Sophie, Paczko, Piotr, Padden, Grace, Padmakumar, Anand, Page, Iain, Page, Nickolas, Page, Valerie, Paget, Jodi, Pagett, Katherine, Paisley, Lee, Pajak, Susie, Pakozdi, Angela, Pal, Soubhik, Pal, Sushi, Palacios, April, Palagiri Sai, Vishnu B, Palaniappan, Vadivu, Palanivelu, Priya, Palfreeman, Adrian, Palihavadana, Shehan, Palit, Deepshikha, Palmer, Alistair, Palmer, Lorna, Palmer, Lynne, Pamphlett, Ian, Pandey, Anmol, Pandian, Nithya, Pandya, Krishnaa, Pandya, Tej, Panes, Alice, Pang, Yee Wei, Pannell, Laura, Pannu, Kanwar, Panthakalam, Sathianathan, Pantin, Charles T, Pao, Norman, Papaconstantinou, Helen, Papineni, Padmasayee, Pappa, Marina, Paques, Kitty, Paradowski, Kerry, Parambil, Vinay, Paranamana, Supathum, Parashar, Siddhant, Parberry, Ian, Parejasanchez, Ana, Parekh, Amy, Parekh, Dhruv, Parfitt, Louise, Parfrey, Helen, Parikh, Omi, Parish, Gemma, Park, John, Park, Liz, Parker, Angela, Parker, Ben, Parker, Carmel, Parker, Emma, Parker, Fiona, Parker, Jacob, Parker, Julie, Parker, Laura, Parker, Lucy, Parker, Sara, Parker, Sean, Parker, Tina, Parkin, Kirstin, Parkinson, Anna, Parkinson, Jill, Parkinson, Lisa, Parkinson, Valerie, Parmar, Chetan, Parmar, Mamta, Parmar, Viraj, Parris, Victoria, Parry, Helen C, Parslow-Williams, Siobhan, Parsonage, Maria, Parsons, Abigail, Parsons, Penny, Parsons, Sarah, Partridge, Richard, Parvin, Kevin, Pass, Kirsten, Passby, Lauren, Pastrana, Juan, Patal, Mital, Patch, Sarah, Patel, Aamie, Patel, Alkesh, Patel, Amisha, Patel, Dakshesh, Patel, Darshna, Patel, Hemani, Patel, Jaymik, Patel, Kamal, Patel, Kayur, Patel, Kiran, Patel, Krish, Patel, Manish, Patel, Martyn, Patel, Mehul, Patel, Naleem, Patel, Nehalbhai, Patel, Prital, Patel, Priti, Patel, Rebecca, Patel, Saagar, Patel, Soonie, Patel, Trishna, Patel, Vishal, Pathak, Sangeeta, Pathan, Nazima, Patience, Alexandra, Patience, Donna, Patrick, Abigail, Patrick, Georgie, Patrick, Jean, Patten, Simon, Pattenden, Ben, Patterson, Ann, Patterson, Charlotte, Patterson, Linda, Patterson, Molly, Patterson, Pauline, Patterson, Robert, Paul, Daniel, Paul, Janice, Paul, Roshni, Pauls, Leigh, Paulus, Stephane, Pavely, Amelia, Pavord, Susan, Payne, Brendan, Payne, David, Payne, Elizabeth, Payne, Ruth, Payne, Tammy, Peacock, Abby, Peacock, Linda, Peacock, Louise, Peacock, Sarah, Peake, Henry, Pearse, Rupert, Pearson, Andrew, Pearson, Daniel, Pearson, Harriet, Pearson, Karen, Pearson, Kirsty, Pearson, Samuel A, Pearson, Sandra, Peasley, Alice, Peddie, Hilary, Peek, Russell, Pegg, Claire, Peglar, Suzannah, Peirce, Benjamin H, Pelham, Claire, Pelle, Belinda, Pemberton, Abigail, Penacerrada, Melchizedek, Pender, Anthony, Pendlebury, Carmel, Pendlebury, Jessica, Pendlebury, Sarah, Penfold, Rachel, Penlington, William, Penman, Catherine, Penman, Julie, Penman, Rachel, Penner, Justin, Penney, Kristi, Penny, Alistair, Penny, James, Pepperell, Justin, Peregrine, Huw, Pereira, Adriana, Pereira, Ana, Pereira, Rita, Pereira Dias Alves, Carlota, Perera, Parmi, Perez, Elena, Perez, Jane, Perinpanathan, Tanaraj, Periyasamy, Lakshmi, Perkins, Francesca, Perkins, Rachel, Perritt, Elizabeth, Perry, Alison, Perry, Emily, Perry, Meghan, Perry, Terrie, Perumpral, Thomas M, Pessoa-Amorim, Guilherme, Petch, Ruth, Peter, Lionel, Peters, Cecilia, Peters, Craig, Peters, Jayne, Peters, Mark, Peters, Steve, Peters, Tim, Petersen, Remy, Peterson, Alexandra, Peto, Leon, Petras, Iulia, Petrou, Ilianna, Petrova, Boyanka, Petrova, Mirela, Pfeffer, Paul, Phanish, Mysore, Phelan, Paul, Philbey, Christopher, Philbin, Jennifer, Philips, Neil, Phillips, Alex, Phillips, Danielle, Phillips, Dylan, Phillips, Karen, Phillips, Pat, Phillips, Rachael, Philpott, Katherine, Phipps, Marie, Phongsathorn, Virach, Phull, Mandeep, Phulpoto, Masroor M, PI, Myat TT, Pick, Sara, Pickard, James, Pickering, Charlotte, Pickering, Gillian, Pickett, Thomas, Pickford, Hayleah, Pickles, Joanna, Pickwell-Smith, Benjamin, Pieniazek, Natalia, Piercy, Charlie, Pieris, Angelo, Pilgrim, Samia, Pillai, Paul Anthony, Pilsworth, Zoe, Pinches, Heather, Pinches, Stacey, Pinder, Julia, Pine, Kirsty, Pinjala, Muni Tejha, Pintus, Stefania, Piper, Graeme, Piper, James, Pipes, Richard, Pirani, Tasneem, Pittman, Marcus, Pitts, Sally, Plaatjies, Nicolene, Plant, Aiden J, Platt, Naomi, Pleass, Robert, Ploeg, Rutger, Plummer, Laura, Plumptre, Charles, Pobjoy, Jonathan, Pogreban, Tatiana, Poku, Stephen, Poles, David, Pollard, Rachel, Pollock, Louisa, Poluyi, Oluwamayowa, Polwarth, Gary John, Pomery, Fiona, Ponnusamy, Ponmurugan, Ponnusamy, Suresh, Ponnuswamy, Aravind, Ponte Bettencourt dos Reis, Inês, Pooboni, Suman, Poole, Alice, Poole, Christopher, Poole, Lorraine, Poole, Lynda, Poole, Michele, Poon, Sharon, Poonian, Tajinder, Poppitt, Ella, Porada, Christopher, Porter, David, Porter, Jo, Porter, Linda, Porter, Ross, Postlethwaite, Kelly, Pothina, Narayana, Potla, Priyadarshan, Potoczna, Dorota, Pott, Jason, Potter, Alison, Potter, Jean, Potter, Kenzi, Potter, Sarah, Potter, Tracey, Potton, Elspeth, Potts, Joanne B, Potts, Julie, Potts, Kathryn, Poultney, Una, Poulton, Katherine, Poustie, Vanessa, Powell, Geneen, Powell, James, Powell, Jordan, Power, Deborah, Power, Nick, Powter, Gillian, Poxon, Joseph, Poyner, Robin, Pradhan, Vidushi, Prady, Helena, Prasad, Aalekh, Prasad, Krishna, Prasad, Maanvi, Prasanth Raj, Fredy, Prasath, Sangeetha, Pratheepkumar, Sindhuja, Pratley, Anezka, Pratt, Steven, Preiss, David, Prendergast, Claire, Prentice, Lynn, Prentice, Peter, Prescott, Verity, Presland, Laura, Prest, Catharine, Preston, Stephen, Pretorius, Martha, Prevatt, Natalie, Prew, Sandra, Price, Ashley, Price, Carly, Price, Claire, Price, David, Price, Elizabeth, Price, Nathan, Price, Vivien, Priddee, Nicole, Priest, Anne, Priestley, Kate, Prieto, Jimena, Primrose, Lorraine, Prince, Clare, Prince, Judith, Prince, Laura, Pring, Janet, Pringle, Shirley, Pristopan, Veronika, Pritchard, Kelly, Pritchard, Lucy, Pritchard, Rhys, Pritchard, Simon, Priyash, Verma, Procter, Andrew, Proctor, Clare, Proudfoot, Rebecca, Prudon, Ben, Pryor, David, Pudi, Solomon, Pugh, Joanne, Pugh, Lawrence, Pugh, Mark T, Pugh, Nichola, Pugh, Richard, Puisa, Veronika, Punia, Kirandip, Punnilath Abdulsamad, Saleel, Purandare, Laura, Purcell, Claire, Purdue, Corrina, Purewal, Bally, Pursell, Molly, Purssord, Gregory, Purvis, Sarah, Puxty, Kathryn, Puyrigaud, Zoe, Pynn, Michael, Qadeer, Tariq, Qayum, Mohammad, Quah, Corrine, Quaid, Sheena, Quail, Nathaniel, Quamina, Charlotte, Quashie, Donna, Quayle, Alice, Quek, Eleanor, Quenby, Siobhan, Qui, Xinyi, Quick, Vanessa, Quigley, Julie, Quijano-Campos, Juan-Carlos, Quinn, Andrew, Quinn, Tom, Quirk, Amy, Quratulain, Quratulain, Qureshi, Danya, Qureshi, Ehsaan, Qureshi, Hafiz, Qureshi, Hasanain, Qureshi, Khadija, Qureshi, Nawaz, Qurratulain, Qurratulain, Qutab, Saad, Rabbani, Muhammad S, Rabbani, Syed, Rabin, Wayne, Rabinowicz, Simon, Raceala, Madalina, Rachman, Raissa, Rad, Laura, Radford, Jane, Radford, Liz, Radhakrishnan, Jayachandran, Rafique, Cecillia, Rafique, Jethin, Rafique, Muhammad, Ragatha, Ravi, Raghunathan, Aiswarya, Raguro, Abigail, Raha, Shankho D, Rahama, Sana, Rahilly, Karen, Rahim, Faisal, Rahimi, Abdul H, Rahimi, Haseena R, Rahman, Muhammad, Rahman, Salim Ur, Rainey, Sharon, Raisova, Lenka, Raj, Arjun, Rajagopalan, Pradeep, Rajaiah, Nithy, Rajasekaran, Arvind, Rajasri, Aylur, Rajeswaran, Thurkka, Rajeswary, Jyothi, Rajkanna, Jeyanthy, Rajmohan, Gayathri, Rallan, Ruth, Ralphs, David, Ralston, Katherine, Ralston, Maximilian, Ram, Matsa, Ramabhadran, Balaji, Ramali, Fathima, Ramali, Mohamed, Ramanan, Athimalaipet, Ramanna, Shashikira, Ramasamy, Maheshi, Ramdin, Dhanishta, Ramirez, Jozel, Ramirez, Mylah, Ramnarain, Geshwin, Ramos, Lidia, Ramraj, Shanthi, Ramshaw, Alex, Rana, Aleem, Rana, Ghulam F, Rana, Rehman, Rand, Abby, Rand, James, Randall, Helen, Randheva, Harpal, Ranga, Poonam, Rangar, Manmeet, Rangarajan, Harini, Ranjan, Sameer, Ranka, Poormina, Rankhelawon, Rajesh, Ranton, Haley, Rao, Anita, Rao, Sandhya, Rao, Sanjay, Rao, Deepak, Rasarathnam, Anuja, Rasheed, Althaf Abdul, Rashid, Alia, Rashid, Khalid, Ratcliff, Simbisai, Ratcliffe, Sam, Ratcliffe, Sophy, Rath, Sanjeev, Rather, Mohmad I, Rathore, Selina, Ratnakumar, Aravinden, Ratoff, Jonathan, Rattehalli, Deepa, Raw, Jason, Rawlins, Hywel, Ray, Gautam, Ray, Michelle, Raymond-White, Adam, Raynard, Dana, Rayner, Benjamin, Rayner, Nicola, Raynsford, Amy, Razvi, Salman, Razvi, Zarine, Read, Kerry, Read, Sarah, Reddy, Ajay, Reddy, Anvesh, Reddy, Harsha, Reddy, Radhika, Reddy, Ravi, Redfern-Walsh, Aine, Redome, Alex, Redome, Joan, Reece, Michelle, Reed, Anna, Reed, John, Rees, Andrew, Rees, Grace, Rees, Ian, Rees, James, Rees, Martyn, Rees, Sarah, Rees, Stephanie, Rees, Tabitha, Regan, Fiona, Regan, Karen, Regan, Susan, Rege, Kanchan, Rehan, Ahmed, Rehman, A, Rehman, Shoib, Rehman, Zainab, Reid, Ada, Reid, Andrew, Reid, Jennifer, Reid, Jeremy, Reid, Sharon, Reilly, Mkyla, Reilly, Robert, Reilly, Shonagh, Reith, Christina, Remegoso, Alda, Rengan, Dinakaran, Renshaw, Stephen, Renu Vattekkat, Remya, Reschreiter, Henrik, Revels, Mark, Rewitzky, Glynis, Reynard, Charles, Reynish, Dominic, Reynolds, Peter, Reynolds, Piero, Rhodes, Jonathan, Riaz, Naghma, Rice, Emily, Rice, Matthew, Rich, Emily, Rich, Mel, Richards, Alison, Richards, Debbie, Richards, Emma, Richards, Liz, Richards, Patricia, Richards, Suzanne, Richardson, Carol, Richardson, Celia, Richardson, Eric, Richardson, Julie, Richardson, Neil, Richardson, Nicky, Richardson, Peter, Riches, Joanne, Riches, Katie, Richmond, Leah, Richmond, Ruth, Ricketts, William, Rickman, Hannah, Ricks, Jonathan, Riddell, Anna, Ridha, Mohamed, Ridley, Carrie, Ridley, Paul, Rieck, Gudrun, Rigby, Linsey, Rigby, Stephen, Riley, Hannah, Riley, Matthew, Riley, Phil, Rimba, Zwesty V P, Rimmer, Dominic, Rintoul, Robert, Riordan, Andrew, Ripley, David, Ripley, Gareth, Rippon, Naomi, Risbridger, Clive, Rishton, Chloe, Riste, Michael, Ritchie, David, Ritchie, Jane, Ritchings, Andy, Rivera Ortega, Pilar, Rivers, Vanessa, Rizvi, Batool, Rizvi, Syed AS, Rizvi, Syed HM, Robb, James, Robb, Matthew, Roberts, David, Roberts, David J, Roberts, Ian, Roberts, Jane, Roberts, Jean, Roberts, Karen, Roberts, Leanne, Roberts, Mark, Roberts, Nicky, Roberts, Philip, Roberts, Rebecca, Robertson, Calum, Robertson, Doug, Robertson, James, Robertson, Jamie, Robertson, Nichola, Robertson, Stuart, Robin, Nicole, Robinson, Caroline, Robinson, Emma, Robinson, Gisela, Robinson, Hannah, Robinson, Jemima, Robinson, Kate, Robinson, Katie, Robinson, Matthew, Robinson, Ryan, Robinson, Sandra, Robinson, Stacey, Robson, Steve, Roche, Lisa, Roche, Samantha, Rock, Jennifer, Rodden, Natalie, Roddick, Alistair, Roddy, Jack, Roderick, Marion, Rodger, Alison, Rodger, Faye, Rodger, Megan, Rodgers, Alicia, Rodgers, Deirdre, Rodgers, Natasha, Rodgers, Penny, Rodrigues, Vanessa, Rodriguez-Belmonte, Rocio, Roe, Nicholas, Roehr, Charles, Rogers, Gill, Rogers, Jason, Rogers, Joanne, Rogers, John, Rogers, Leigh, Rogers, Lindsay, Rogers, Louise, Rogers, Michaela, Rogers, Paula, Rogers, Susan, Rogers, Thomas, Rokadiya, Sakib, Rollins, Lee, Rollo, Jennifer, Rolls, Catherine, Roman, Atal, Rook, Claire, Rook, Rashmi, Rooney, Kevin, Rooney, Lynsey, Roper, Gemma, Rosaroso, Lace P, Rose, Alastair, Rose, Annie, Rose, David, Rose, Rachel, Rose, Steve, Rose, Vikkie, Rose, Zoe, Rosier, Josephine, Ross, Jack, Rossdale, Jenny, Ross-Parker, Andrew, Rothman, Alex, Rothwell, Joanne, Roughley, Lindsay, Rowan, Kathryn, Rowan, Neil, Rowan, Stephen, Rowan-Ferry, Scott, Rowe, Anna, Rowe-Leete, Louise, Rowlands, Benjamin, Rowley, Megan, Roy, Aparajita, Roy, Subarna, Roynon-Reed, Anna, Rozewicz, Sam, Rudd, Alison, Rudenko, Anna, Rudrakumar, Senthan, Rudran, Banu, Ruff, Shannon, Rughani, Prita, Rundell, Sharon, Rushmer, Jeremy, Rushworth, Rosemary, Rusk, Darren, Russell, Peter, Russell, Richard, Russo, Cristina, Rutgers, Marieke, Ryan, Aidan, Ryan, Brendan, Ryan, Lucy, Ryan, Matthew, Ryan, Pat, Ryan, Phil, Ryan-Wakeling, Declan, Rylance, Nick, Saad, M, Sabale, Javeson, Sabaretnam, Suganya, Sabat, Umar, Sadiq, Noman, Sadler, Emma, Saez-Garcia-Holloway, Maria-Isabel, Saffy, Ashiq, Sage, Beth, Sagoo, Harkiran, Sagrir, Sobia, Saha, Rajnish, Saha, Sian, Sahdev, Nikhil, Sahedra, Sarvjit, Sahota, Jagdeep, Said, Nooria, Sakthi, Sreekanth, Sakuri, Hikari, Saladi, Murthy, Salam, Abdul, Salawu, Sofiyat, Salberg, Armorel, Salciute, Erika, Saleeb, Gina, Saleh, Mumtaz, Salih, Hizni, Salih, Laylan, Salisbury, Sarah, Saliu, SiteEneye, Salman, Rustam, Salmon, Angela, Salmon, Jenny, Salmons, Nichola, Salutous, Dario, Sam, Mfon, Sam, Sally, Samakomva, Tinashe, Samlal, Renaldo, Sammons, Emily, Sammut, David, Sammut, Mark, Sammut, Zoe, Sampath, Sunitha, Sampson, Claire, Sampson, Julia, Samson, Aashna, Samson, Anda, Samuel, Johnson, Samuel, Lorraine, Samuel, Merna, Samuel, Reena, Samuel, Thomas DL, Samuel, Younan, Samuels, Elsward, Samuels, Theo, Samways, Joanna, Samyraju, Manjula, San Diego, Francisco, Sana, Ilves, Sanchez, Veronica, Sanchez Gonzalez, Amada, Sanda-Gomez, Alina, Sandajam, Paul, Sandercock, Peter, Sanderson, Amy, Sanderson, Colleen, Sanderson, Tom, Sandhu, Kuljinder, Sandhu, Loveleen, Sandow, Sam, Sandrey, Victoria, Sands, Sarah, Sangombe, Mirriam, Sanju, Mathew, Santos, Filipa, Santosh, Rojy, Sanyal, Jayanta, Sanz-Cepero, Aureo F, Saralaya, Dinesh, Saraswatula, Arun, Sarella, Joshua, Sarfatti, Avishay, Sargent, Rebecca, Sari, Beatrix, Sarkar, Khatija, Sarkar, Rahuldeb, Sarma, Sruthi, Sarwar, Zainab, Sass, Thea, Sathe, Sonia, Sathianandan, Sobitha, Sathyanarayanan, Abilash, Sathyanarayanan, Lavanya SJP, Sathyapalan, Thozhukat, Satodia, Prakash, Saulite, Vera, Saunders, Andrew, Saunders, Rachel, Saunders, Samantha, Saunderson, Anne, Savill, Heather, Savlani, Karishma, Saxena, Gauri, Saxton, Matthew, Sayan, Amrinder, Scaletta, Diane, Scally, Marta, Scanlon, Deborah, Scanlon, Jeremy, Scarratt, Lyndsay, Scattergood, Sean, Schadenberg, Alvin, Schneblen, Wendy, Schofield, Rebecca, Schofield, Samuel, Scholes, David, Scholes, Karen, Schoolmeesters, Alex, Schumacher, Natasha, Schunke, Nicola, Schuster Bruce, Martin, Schwarz, Karin, Scobie, Antonia, Scorrer, Tim, Scott, A., Scott, Alistair, Scott, Anne, Scott, Catherine, Scott, Christine, Scott, Emily, Scott, Graham, Scott, Kathyn, Scott, Leanne, Scott, Martha, Scott, Michelle, Scott, Stephen, Scott, Timothy, Scourfield, Sarah, Scrase, Wendy, Scullion, Angela, Scullion, Therese, Seabury, Richard, Seager, Emily, Seagrave, Cathy, Seals, Deborah, Seaman, Rebecca, Sear, Eleanor, Seaton, Isabella, Seckington, Anna, Sedano, Joanna, Seddon, Deborah, Seddon, Gabrielle, Seelarbokus, Muhammad A, Sefton, Christopher, Segovia, Matias, Seidu, Fatima, Sekadde, Gillian, Sekhar, Mallika, Selby, Faye, Selby, Georgina, Sell, Jo, Sellar, Claire, Sellers, Katharine, Selley, Joseph, Sellick, Victoria, Selvadurai, Gobika, Selvarajah, Brintha, Selvaskandan, Haresh, Selvendran, Subothini S, Semple, Gary, Sen, Nandini, Sen, Seema, Sengupta, Aditya, Sengupta, Niladri, Senior, Helen, Senior, Peter, Senra, Susana, Senya, HoJan, Setty, Niranjan, Seward, Abigail, Sewdin, Teswaree, Seymour, Jack, Shabbir, Hussam, Shackleton, Tracey, Shackley, Fiona, Shafi, Tariq, Shah, Aashni, Shah, Ahmar, Shah, Anand, Shah, Bhavni, Shah, Momin, Shah, Neil, Shah, Pallav, Shah, Priyank, Shah, Qasim, Shah, Sarfaraz H, Shah, Snehal, Shah, Suraj, Shah, Syed, Shah, Wajid, Shahad, Saarma, Shahi, Sousan, Shahnazari, Sipan, Shahzeb, Muhammad, Shaibu, Aisha, Shaida, Zara, Shaikh, Amina Y, Shaikh, Maliha, Shail, Rajit, Shaji, Mariya, Shakeel, Muhammad, Shalan, Korah, Shamim, Nadia, Shams, Kazi, Shanahan, Alison, Shanahan, Thomas, Shanmugaranjan, Shaminie, Sharaf, Hamed, Sharafat, Muhammad, Sharif, Asir, Sharma, Ajay, Sharma, Akhilesh, Sharma, Ash, Sharma, Bhawna, Sharma, Mona, Sharma, Ojasvi, Sharma, Poonam, Sharma, Rajeev, Sharma, Sanjeev, Sharma, Sarkhara, Sharma, Shriv, Sharma, Sonal, Sharp, Alexander, Sharp, Charles, Sharp, Gemma, Sharratt, Paula, Sharratt, Phoebe, Sharrocks, Katherine, Sharrod, Emma, Shaw, Christopher, Shaw, Daisy, Shaw, David, Shaw, Deborah, Shaw, Joanne, Shaw, Jonathan, Shaw, Lisa, Shaw, Tomos G, Shawcross, Anna, Shawe, Jill, Shayler, Lou, Shazad, Khuram, Shedwell, Sophy, Sheffield, Jonathan, Shehata, Zak, Sheik, Arshiya, Sheikh, Asif, Sheikh, Noorann, Sheldon, Laura, Shelley, Benjamin, Shelton, Sarah, Shenoy, Anil, Shenton, Julie, Shepherd, Amy, Shepherd, Kate, Shepherd, Lorna, Shepherd, Scott, Sheppeard, Rhian, Sheridan, Helen, Sheridan, Ray, Sherridan, Samuel, Sherris, Leanne, Sherwin, Susanna, Shibly, Shaad, Shiers, Roger, Shioi, Chiaki, Shirgaonkar, Anand, Shirley, Kim, Shonubi, Adebusola, Short, Angela, Shortland, Richard, Shortman, Rob, Shotton, Rohan, Shotton, Sarah, Shpuza, Ervin, Shrestha, Nora, Shuker, Karen, Shurmer, Jack, Siame, Gilbert, Siamia, Loria, Sibanda, Zanele, Sidaway, Claire, Siddavaram, Seshnag, Siddique, Nasir, Siddique, Sohail, Sikondari, Nyma, Silva Moniz, Claudia, Silverstone, Mike, Sim, Malcolm, Simangan, Theresa, Simbi, Vimbai, Sime, Robert, Simmons, Oliver, Simms, Richard, Simon, Merritt, Simon, Natalie, Simpson, Angela, Simpson, Anna, Simpson, Danny, Simpson, Georgina, Simpson, Joanne, Simpson, John, Simpson, Kerry, Simpson, Phillip, Simpson, Thomas, Simpson, Andrew, Simpson, Kathryn, Sing, Cindy, Singh, Ankita, Singh, Claire, Singh, Jayaprakash, Singh, Jyoti, Singh, Lokeshwar, Singh, Manjeet, Singh, Nadira, Singh, Pankaj, Singh, Prabhsimran, Singh, Salil, Singh, Saurabh, Singhal, Parag, Singizi, Bryan, Sinha, Manas, Sinha, Utkarsh, Sisson, Guy, Sithiravel, Sarah, Sivakumar, Karthikadevi, Sivakumar, Shanmugasundaram, Sivakumran, Darsh, Sivanadarajah, Sivanthi, Sivasothy, Pasupathy-Rajah, Sivers, Rebecca, Sivyer, Alison, Skehan, Nicole, Skelly, Robert, Skelton, Orlagh, Skene, Imogen, Skill, Michael J, Skinner, Denise, Skinner, Tabitha, Skinner, Victoria, Skorko, Agnieszka, Skorupinska, Iwona, Skorupinska, Mariola, Slack, Amy, Slack, Katie, Slack, Wendy, Slade, Heather, Slade, Helen, Slade, Mark, Slater, Helen, Slater, Lynda, Slawson, Nicola, Sloan, Andrew, Sloan, Brendan, Sloan, Derek, Sloane, Geraldine, Small, Benjamin, Small, Ellen, Small, Emma, Small, Samuel, Smallshaw, Karen D, Smallwood, Andy, Smit, Carien, Smith, Aileen, Smith, Alex, Smith, 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Published
2021
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49. Surgery versus cast immobilisation for adults with a bicortical fracture of the scaphoid waist (SWIFFT): a pragmatic, multicentre, open-label, randomised superiority trial

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Dias, Joseph J, Brealey, Stephen D, Fairhurst, Caroline, Amirfeyz, Rouin, Bhowal, Bhaskar, Blewitt, Neil, Brewster, Mark, Brown, Daniel, Choudhary, Surabhi, Coapes, Christopher, Cook, Liz, Costa, Matthew, Davis, Tim, Di Mascio, Livio, Giddins, Grey, Hedley, Helen, Hewitt, Catherine, Hinde, Sebastian, Hobby, Jonathan, Hodgson, Stephen, Jefferson, Laura, Jeyapalan, Kanagaratnam, Johnston, Phillip, Jones, Jonathon, Keding, Ada, Leighton, Paul, Logan, Andrew, Mason, Will, McAndrew, Andrew, McNab, Ian, Muir, Lindsay, Nicholl, James, Northgraves, Matthew, Palmer, Jared, Poulter, Rob, Rahimtoola, Zulfi, Rangan, Amar, Richards, Simon, Richardson, Gerry, Stuart, Paul, Taub, Nicholas, Tavakkolizadeh, Adel, Tew, Garry, Thompson, John, Torgerson, David, and Warwick, David

Published
2020
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