1. Memory and Executive Dysfunction Predict Complex Activities of Daily Living Impairment in Amnestic Multi-Domain Mild Cognitive Impairment
- Author
-
José Luis Vicente-Villardón, Julián Benito-León, Ricardo García, Jesus L. Cacho, María Victoria Perea-Bartolomé, Valentina Ladera-Fernández, Damián Pastorino-Mellado, Rosalía García-García-Patino, and Alex J. Mitchell
- Subjects
Male ,0301 basic medicine ,medicine.medical_specialty ,Activities of daily living ,Disease ,Audiology ,Executive Function ,03 medical and health sciences ,0302 clinical medicine ,Memory ,Activities of Daily Living ,medicine ,Explicit memory ,Humans ,Dementia ,Cognitive Dysfunction ,Cognitive impairment ,Aged ,business.industry ,General Neuroscience ,Cognition ,General Medicine ,Mental Status and Dementia Tests ,Executive functions ,medicine.disease ,Psychiatry and Mental health ,Clinical Psychology ,030104 developmental biology ,Female ,Amnesia ,Geriatrics and Gerontology ,business ,030217 neurology & neurosurgery ,Executive dysfunction - Abstract
BACKGROUND Specific cognitive alterations could be one of the predictors that lead to the complex activities of daily living (CADL) impairment in mild cognitive impairment (MCI) and, hence, help to explain the continuum between MCI and dementia. OBJECTIVE We aimed to reevaluate the existing uncertainty regarding the impact of memory and executive functions on CADL in patients with MCI. METHODS Caregivers of 161 patients with amnestic multi-domain MCI and of 150 patients with incipient Alzheimer's disease as well as 100 age-, sex-, and education-matched controls, completed the Interview for Deterioration in Daily Living Activities in Dementia, a suitable instrument for the description and discrimination of CADL. In addition, all patients and controls were assessed with a neuropsychological battery to measure explicit memory and executive functions performance. RESULTS Multiple regression analyses showed that in the group of patients with amnestic multi-domain MCI, 67.4% of the variability of the CADL impairment was explained by worse performance on executive functions tests (p
- Published
- 2020