22 results on '"Jessica Kong"'
Search Results
2. Effect of craniofacial morphology on gingival parameters of mandibular incisors
- Author
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Jessica Kong, James K. Hartsfield, Johan Aps, Steven Naoum, Richard Lee, Leticia Algarves Miranda, and Mithran S. Goonewardene
- Subjects
Orthodontics - Abstract
Objectives To investigate the association between the width of keratinized gingiva (WKG), gingival phenotype (GP), and gingival thickness (GT) with craniofacial morphology in sagittal and vertical dimensions. Materials and Methods WKG, GP, and GT of mandibular anterior teeth in 177 preorthodontic patients (mean age 18.38 ± 5.16 years) were assessed clinically using a periodontal probe, a Colorvue Biotype Probe, and ultrasound by a single examiner. Patients were grouped into skeletal Class I, II, and III and hyperdivergent, normodivergent, and hypodivergent based on ANB and SN-MP angles. Mandibular incisor inclination (L1-NB) was also measured. Clinical and cephalometric measurements were repeated to assess inter- and intraexaminer reproducibility. Results A significant association was found between thin GP and skeletal Classes I and III for the left mandibular central incisor (MCI; P = .0183). In skeletal Class III patients, L1-NB angle demonstrated a decreasing trend as phenotype thickness decreased. A significant association was found between thin phenotype and normodivergent and hypodivergent groups for MCIs (left: P = .0009, right: P = .00253). No significant association between WKG or GT and craniofacial morphology was found. Conclusions Thin GP is associated with skeletal Class I and III for the left MCI. Thin GP is associated with hypodivergent and normodivergent skeletal patterns for the MCIs. There was no association between WKG and GT and craniofacial morphology in both skeletal and vertical dimensions. Dental compensations that exist due to different craniofacial morphology may influence the GP.
- Published
- 2023
3. Exploratory evaluation of 18F‐MK‐6240 tau PET positivity in TANGO phase 2 clinical trial of gosuranemab (BIIB092) in Mild Cognitive Impairment and mild Alzheimer’s disease
- Author
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Annie M Racine, Jessica A. Collins, Jonathan M DuBois, John Seibyl, Jessica Kong, Yumeng Li, John O'Gorman, Sara J. Makaretz, Stephanie Jones, Danielle Graham, Raj Rajagovindan, Melanie Shulman, and Samantha Budd Haeberlein
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Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Epidemiology ,Health Policy ,Neurology (clinical) ,Geriatrics and Gerontology - Published
- 2022
4. Nanowire Architectures Improve Ion Uptake Kinetics in Conjugated Polymer Electrochemical Transistors
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David S. Ginger, Jessica Kong, Rajiv Giridharagopal, and Jiajie Guo
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chemistry.chemical_classification ,Materials science ,business.industry ,Transconductance ,Kinetics ,Nanowire ,Field effect ,Polymer ,Active layer ,Threshold voltage ,Ion ,chemistry ,Optoelectronics ,General Materials Science ,business - Abstract
Organic electrochemical transistors are believed to face an inherent material design tension between optimizing for ion mobility and for electronic mobility. These devices transduce ion uptake into electrical current, thereby requiring high ion mobility for efficient electrochemical doping and rapid turn-on kinetics and high electronic mobility for the maximum transconductance. Here, we explore a facile route to improve operational kinetics and volumetric capacitance in a high-mobility conjugated polymer (poly[2,5-(2-octyldodecyl)-3,6-diketopyrrolopyrrole-alt-5,5-(2,5-di(thien-2-yl)thieno [3,2-b]thiophene)], DPP-DTT) by employing a nanowire morphology. For equivalent thicknesses, the DPP-DTT nanowire films exhibit consistently faster kinetics (∼6-10× faster) compared to a neat DPP-DTT film. The nanowire architectures show ∼4× higher volumetric capacitance, increasing from 7.1 to 27.7 F/cm3, consistent with the porous structure better enabling ion uptake throughout the film. The nanowires also exhibit a small but energetically favorable shift in a threshold voltage of ∼17 mV, making the nanostructured system both faster and energetically easier to electrochemically dope compared to neat films. We explain the variation using two atomic force microscopy methods: in situ electrochemical strain microscopy and nanoinfrared imaging via photoinduced force microscopy. These data show that the nanowire film's structure allows greater swelling and ion uptake throughout the active layer, indicating that the nanowire architecture exhibits volumetric operation, whereas the neat film is largely operating via the field effect. We propose that for higher-mobility materials, casting the active layer in a nanowire form may offer faster kinetics, enhanced volumetric capacitance, and possibly lower threshold voltage while maintaining desirable device performance.
- Published
- 2021
5. Longitudinal Cognitive Decline in Patients With Mild Cognitive Impairment or Dementia Due to Alzheimer's Disease
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E. Ratti, Yen Ying Lim, Ellen Huang, Jessica Kong, Paul Maruff, and Judith Jaeger
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medicine.medical_specialty ,Neurology ,business.industry ,Australia ,Cognition ,Disease ,Audiology ,Neuropsychological Tests ,medicine.disease ,Alzheimer Disease ,Disease Progression ,Medicine ,Dementia ,Biomarker (medicine) ,Humans ,Cognitive Dysfunction ,Cognitive decline ,business ,Cognitive impairment ,Episodic memory - Abstract
Sensitive cognitive assessments accurately detect and track cognitive decline in Alzheimer’s disease. The Cogstate battery was used to measure cognitive change in cognitively normal participants and in individuals with mild cognitive impairment and mild Alzheimer’s disease enrolled in the Australian Imaging, Biomarker and Lifestyle Rate of Change Substudy. Over 18 months, verbal episodic memory performance declined for mild cognitive impairment and mild Alzeheimer’s disease groups when compared to cognitively normal participants. Frequent assessments of episodic memory may facilitate early detection of cognitive decline due to Alzheimer’s disease.
- Published
- 2022
6. Baseline biomarker (tau PET) characteristics from TANGO: A phase 2 trial of gosuranemab (BIIB092) in early Alzheimer's disease
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Annie M. Racine, Raj Rajagovindan, Jessica A. Collins, Jessica Kong, Yumeng Li, John O'Gorman, Stephanie Jones, Danielle Graham, Elena Ratti, and Melanie Shulman
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Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Epidemiology ,Health Policy ,Neurology (clinical) ,Geriatrics and Gerontology - Published
- 2021
7. Baseline characteristics from TANGO: Phase 2 study to evaluate gosuranemab (BIIB092) in patients with early Alzheimer’s disease
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Annie M. Racine, Melanie B Shulman, Louis Viollet, Philipp von Rosenstiel, John O'Gorman, Tracy Mirabile, Elena Ratti, Dominic M. Walsh, Raj Rajagovindan, Danielle Graham, Jessica Kong, Stephanie Jones, and Daniela Ramirez Schrempp
- Subjects
medicine.medical_specialty ,Epidemiology ,business.industry ,Health Policy ,Phases of clinical research ,Disease ,Clinical trial ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Baseline characteristics ,Internal medicine ,Medicine ,In patient ,Neurology (clinical) ,Geriatrics and Gerontology ,business - Published
- 2020
8. The Politicization of Music through Nostalgic Mediation
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Jessica Kong and Anthony Fung
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History ,Mediation ,Media studies - Published
- 2020
9. Effects of Language History on Sentence Recognition in Noise or Two-Talker Speech: Monolingual, Early Bilingual, and Late Bilingual Speakers of English
- Author
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Diana Regalado, Lauren Calandruccio, Emily Buss, and Jessica Kong
- Subjects
Adult ,Male ,medicine.medical_specialty ,Speech perception ,Adolescent ,Multilingualism ,Audiology ,050105 experimental psychology ,03 medical and health sciences ,Speech and Hearing ,Young Adult ,0302 clinical medicine ,Factor (programming language) ,medicine ,Humans ,Speech ,0501 psychology and cognitive sciences ,030223 otorhinolaryngology ,Research Articles ,computer.programming_language ,Language ,05 social sciences ,Linguistics ,Sentence recognition ,Noise ,Speech Perception ,Female ,Psychology ,computer - Abstract
Purpose Language history is an important factor in masked speech recognition. Listeners who acquire the target language later in life perform more poorly than native speakers. However, there are inconsistencies in the literature regarding performance of bilingual speakers who begin learning the target language early in life. The purpose of this experiment was to evaluate speech-in-noise and speech-in-speech recognition for highly proficient early bilingual listeners compared to monolingual and late bilingual listeners. Method Three groups of young adults participated: native monolingual English speakers, bilingual Mandarin–English speakers who learned English from birth (early bilinguals), and native Mandarin speakers who learned English later in life (late bilinguals). All participants had normal hearing and were full-time college students. Recognition was assessed for English sentences in speech-shaped noise and two-talker English speech. Participants provided linguistic and demographic information, and late bilinguals completed the Versant test of spoken English abilities. Results All listeners performed better in speech-shaped noise than two-talker speech. Performance was similar for monolingual and early bilinguals. Late bilinguals performed more poorly overall. There was evidence for a stronger association between masked speech recognition and English dominance for late bilinguals compared to early bilinguals. Conclusion These results support the conclusion that bilingualism itself does not necessarily result in a disadvantage when recognizing masked speech in noise and speech in speech. For populations similar to those studied here (highly proficient early bilinguals), it would be appropriate to evaluate masked speech recognition using the same simple stimuli and normative data used for monolingual speakers of English.
- Published
- 2019
10. Identifying Nanoscale Structure–Function Relationships Using Multimodal Atomic Force Microscopy, Dimensionality Reduction, and Regression Techniques
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Jeffrey S. Harrison, Jessica Kong, Rajiv Giridharagopal, and David S. Ginger
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Materials science ,Dimensionality reduction ,02 engineering and technology ,Conductive atomic force microscopy ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Scanning probe microscopy ,Principal component analysis ,Microscopy ,Principal component regression ,General Materials Science ,Polymer blend ,Physical and Theoretical Chemistry ,0210 nano-technology ,Biological system ,Nanoscopic scale - Abstract
Correlating nanoscale chemical specificity with operational physics is a long-standing goal of functional scanning probe microscopy (SPM). We employ a data analytic approach combining multiple microscopy modes using compositional information in infrared vibrational excitation maps acquired via photoinduced force microscopy (PiFM) with electrical information from conductive atomic force microscopy. We study a model polymer blend comprising insulating poly(methyl methacrylate) (PMMA) and semiconducting poly(3-hexylthiophene) (P3HT). We show that PiFM spectra are different from FTIR spectra but can still be used to identify local composition. We use principal component analysis to extract statistically significant principal components and principal component regression to predict local current and identify local polymer composition. In doing so, we observe evidence of semiconducting P3HT within PMMA aggregates. These methods are generalizable to correlated SPM data and provide a meaningful technique for extracting complex compositional information that is impossible to measure from any one technique.
- Published
- 2018
11. The effect of target/masker fundamental frequency contour similarity on masked-speech recognition
- Author
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Emily Buss, Jessica Kong, Lauren Calandruccio, Lori J. Leibold, Jacob Oleson, Peter A. Wasiuk, and Ann Holmes
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Speech Acoustics ,Masking (art) ,Male ,Speech perception ,Similarity (geometry) ,Acoustics and Ultrasonics ,Adolescent ,Computer science ,Speech recognition ,Perceptual Masking ,Fundamental frequency ,Signal-To-Noise Ratio ,Psychological and Physiological Acoustics ,Noise ,Young Adult ,Signal-to-noise ratio ,Arts and Humanities (miscellaneous) ,Speech Perception ,Voice ,Humans ,Female - Abstract
Greater informational masking is observed when the target and masker speech are more perceptually similar. Fundamental frequency (f0) contour, or the dynamic movement of f0, is thought to provide cues for segregating target speech presented in a speech masker. Most of the data demonstrating this effect have been collected using digitally modified stimuli. Less work has been done exploring the role of f0 contour for speech-in-speech recognition when all of the stimuli have been produced naturally. The goal of this project was to explore the importance of target and masker f0 contour similarity by manipulating the speaking style of talkers producing the target and masker speech streams. Sentence recognition thresholds were evaluated for target and masker speech that was produced with either flat, normal, or exaggerated speaking styles; performance was also measured in speech spectrum shaped noise and for conditions in which the stimuli were processed through an ideal-binary mask. Results confirmed that similarities in f0 contour depth elevated speech-in-speech recognition thresholds; however, when the target and masker had similar contour depths, targets with normal f0 contours were more resistant to masking than targets with flat or exaggerated contours. Differences in energetic masking across stimuli cannot account for these results.
- Published
- 2019
12. Control and Characterization of Organic Solar Cell Morphology Through Variable-Pressure Solvent Vapor Annealing
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Timothy L. Kelly, Seth M. McAfee, Derek Zomerman, Jessica Kong, and Gregory C. Welch
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Materials science ,Organic solar cell ,Annealing (metallurgy) ,Scattering ,Energy Engineering and Power Technology ,Model system ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,7. Clean energy ,01 natural sciences ,0104 chemical sciences ,Crystallinity ,Solvent vapor ,Chemical engineering ,Variable pressure ,Microscopy ,Materials Chemistry ,Electrochemistry ,Chemical Engineering (miscellaneous) ,Electrical and Electronic Engineering ,0210 nano-technology - Abstract
Solvent vapor annealing (SVA) of organic photovoltaics (OPVs) has become an important postdeposition treatment, but current OPV SVA methods are difficult to reproduce and neither tunable nor scalable. Herein, it is shown that a variable-pressure solvent vapor annealing (VP-SVA) system can be used to reproducibly and tunably anneal OPV active layers to produce highly controlled film morphologies. We show that VP-SVA is useful not only for the well-studied P3HT:PC61BM model system, but also for modern OPV active layers based on nonfullerene acceptors. Phase separation and material crystallinity are precisely tuned by controlling the solvent vapor concentration used during the annealing process, as evidenced by photoinduced force microscopy (PiFM) and grazing incidence wide-angle X-ray scattering (GIWAXS). The results show that overannealing occurs at saturated solvent vapor pressures, highlighting the importance of the VP-SVA technique.
- Published
- 2018
13. P3‐033: RANDOMIZED, DOUBLE‐BLIND, PLACEBO‐CONTROLLED STUDY TO ASSESS TREATMENT OF BIIB092 IN SUBJECTS WITH EARLY ALZHEIMER'S DISEASE: TANGO PHASE 2 STUDY DESIGN
- Author
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Kumar Kandadi Muralidharan, Michael Grundman, Elena Ratti, Chris Henderson, Bjoern Sperling, Danielle Graham, Jessica Kong, Samantha Budd Haeberlein, Sue T. Griffin, John O'Gorman, Anirvan Ghosh, Li Zhang, Judith Jaeger, Raj Rajagovindan, and Tina Olsson
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Epidemiology ,business.industry ,Health Policy ,Placebo-controlled study ,Phases of clinical research ,Disease ,Double blind ,03 medical and health sciences ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,030104 developmental biology ,0302 clinical medicine ,Developmental Neuroscience ,Internal medicine ,Medicine ,Neurology (clinical) ,Geriatrics and Gerontology ,business ,030217 neurology & neurosurgery - Published
- 2018
14. The importance of residual kidney function in haemodialysis patients
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Jessica, Kong, Matthew, Davies, and Peter, Mount
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Health Status ,Urinalysis ,Kidney ,Treatment Outcome ,Predictive Value of Tests ,Renal Dialysis ,Risk Factors ,Creatinine ,Quality of Life ,Humans ,Urea ,Kidney Diseases ,Biomarkers ,Glomerular Filtration Rate - Abstract
In contrast to peritoneal dialysis, residual kidney function (RKF) is commonly disregarded for haemodialysis (HD) patients and not regularly monitored or taken into account in routine clinical care. This is despite evidence that higher levels of RKF in HD patients are associated with better outcomes, including survival, total solute clearance, nutrition, inflammation and fluid balance. This review aims to summarise the clinical effects of RKF specifically in HD patients. Some level of RKF is present in over 80% of patients at the time of dialysis initiation, and while this declines over time, up to 30% of patients on HD for 5 years still have a measurable level of native kidney function. There is little evidence on how best to preserve RKF in HD patients, although it has been observed that intensive HD regimens in incident HD patients appear to accelerate RKF decline. RKF is not commonly factored into HD prescription and measures of adequacy, despite the fact that some guidelines such as Kidney Disease Outcomes Quality Initiative (KDOQI) and European Best Practice Guidelines suggest that it is reasonable to do so. This likely relates, at least in part, to perceived concerns regarding the inconvenience of timed urine collections and to the complexity and lack of consensus regarding the methods for integrating the intermittent clearance of HD with the continuous clearance of native renal function. Further research is required into how best to maintain and maximise the benefits of RKF in HD patients.
- Published
- 2018
15. Corrigendum to 'Effects of Delayed-release Dimethyl Fumarate (DMF) on Health-related Quality of Life in Patients With Relapsing-remitting Multiple Sclerosis: An Integrated Analysis of the Phase 3 DEFINE and CONFIRM Studies: [Clinical Therapeutics 36 (2014) 1958-1971]
- Author
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Mariko, Kita, Robert J, Fox, Ralf, Gold, Gavin, Giovannoni, J Theodore, Phillips, Sujata P, Sarda, Jessica, Kong, Vissia, Viglietta, Sarah I, Sheikh, Macaulay, Okwuokenye, and Ludwig, Kappos
- Published
- 2018
16. Effects of Delayed-Release Dimethyl Fumarate (DMF) on Health-Related Quality of Life in Patients With Relapsing-Remitting Multiple Sclerosis: An Integrated Analysis of the Phase 3 DEFINE and CONFIRM Studies
- Author
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Sujata P. Sarda, Ralf Gold, Mariko Kita, J. Theodore Phillips, Ludwig Kappos, Macaulay Okwuokenye, Sarah Sheikh, Jessica Kong, Robert J. Fox, Vissia Viglietta, and Gavin Giovannoni
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Visual analogue scale ,Dimethyl Fumarate ,Health Status ,Population ,Placebo ,law.invention ,Young Adult ,chemistry.chemical_compound ,Multiple Sclerosis, Relapsing-Remitting ,Randomized controlled trial ,Quality of life ,law ,Internal medicine ,medicine ,Humans ,Pharmacology (medical) ,education ,Pain Measurement ,Pharmacology ,education.field_of_study ,Expanded Disability Status Scale ,Dimethyl fumarate ,business.industry ,Therapeutic effect ,Middle Aged ,humanities ,Treatment Outcome ,chemistry ,Delayed-Action Preparations ,Quality of Life ,Physical therapy ,Female ,business ,Immunosuppressive Agents - Abstract
Purpose Delayed-release dimethyl fumarate (DMF; also known as gastro-resistant DMF ) has been reported to have clinical and neuroradiologic efficacy in people with relapsing-remitting multiple sclerosis (RRMS) in the Phase 3 DEFINE and CONFIRM studies. An integrated analysis of data from DEFINE and CONFIRM was conducted to estimate more precisely the therapeutic effects of delayed-release DMF. Here we describe the impact of RRMS on health-related quality of life (HRQoL) at baseline and assess the effects of delayed-release DMF on prespecified HRQoL end points over 2 years. Methods Patients with RRMS were randomly assigned to receive delayed-release DMF 240 mg PO BID or TID or matching placebo for up to 2 years (96 weeks). As a tertiary end point in both studies, patient-reported HRQoL was assessed using the Physical and Mental Component Summaries (PCS and MCS, respectively) of the 36-item Short Form Health Survey (SF-36); global assessment of well-being, as measured on a visual analog scale (VAS); and the EuroQoL-5D (EQ-5D) VAS, administered at baseline and at weeks 24, 48, and 96. Higher scores suggested better HRQoL. Findings The integrated analysis included 2301 patients treated with delayed-release DMF BID (n = 769) or TID (n = 761) or placebo (n = 771). The mean PCS and MCS scores at baseline were lower overall compared with those reported in the general US population and were ≥5 points lower (a clinically meaningful difference) in patients with a baseline Expanded Disability Status Scale (EDSS) score of ≥2.5 compared with those in patients with a baseline EDSS score of 0. At 2 years, mean PCS and MCS scores were increased from baseline in the patients treated with delayed-release DMF, whereas the mean PCS and MCS scores were decreased from baseline in the placebo group; the difference in PCS and MCS scores was significant for the delayed-release DMF BID and TID groups compared with placebo. SF-36 subscale scores generally remained stable or were improved relative to baseline in patients treated with delayed-release DMF and decreased in patients receiving placebo; improvements were significant for delayed-release DMF BID and TID versus placebo on most subscales. Compared with that in the placebo group, the proportions of patients in the delayed-release DMF groups exhibiting a ≥5-point improvement in SF-36 score were significantly higher. The following factors were found to be predictive of improved PCS and MCS scores at 2 years: delayed-release DMF treatment, lower baseline EDSS score, age ≤40 years (PCS only), and corresponding lower baseline PCS or MCS score. Changes from baseline in VAS and EuroQoL-5D scores were generally consistent with changes in SF-36 scores. Implications These HRQoL benefits parallel the improvements in clinical and magnetic resonance imaging end points with delayed-release DMF, suggesting that delayed-release DMF treatment improves patient-perceived health status as well as neurologic and physical functioning. ClinicalTrials.gov identifiers: NCT0042012; NCT00451451.
- Published
- 2014
17. Thermal Decomposition Mechanism for Ethanethiol
- Author
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William F. Melhado, Jessica Kong, Jared C. Whitman, Daniel E. Anderson, Thomas W. Cowell, AnGayle K. Vasiliou, and Margaret D. Phillips
- Subjects
010304 chemical physics ,Ethanethiol ,Thermal decomposition ,Analytical chemistry ,Infrared spectroscopy ,Photoionization ,010402 general chemistry ,Mass spectrometry ,01 natural sciences ,Decomposition ,Article ,0104 chemical sciences ,chemistry.chemical_compound ,chemistry ,0103 physical sciences ,Vacuum chamber ,Physical and Theoretical Chemistry ,Molecular beam - Abstract
The thermal decomposition of ethanethiol was studied using a 1 mm × 2 cm pulsed silicon carbide microtubular reactor, CH3CH2SH + Δ → Products. Unlike previous studies these experiments were able to identify the initial ethanethiol decomposition products. Ethanethiol was entrained in either an Ar or a He carrier gas, passed through a heated (300–1700 K) SiC microtubular reactor (roughly ≤100 μs residence time) and exited into a vacuum chamber. Within one reactor diameter the gas cools to less than 50 K rotationally, and all reactions cease. The resultant molecular beam was probed by photoionization mass spectroscopy and IR spectroscopy. Ethanethiol was found to undergo unimolecular decomposition by three pathways: CH3CH2SH → (1) CH3CH2 + SH, (2) CH3 + H2C═S, and (3) H2C═CH2 + H2S. The experimental findings are in good agreement with electronic structure calculations.
- Published
- 2017
18. MECHANISM OF THE THERMAL DECOMPOSITION OF ETHANETHIOL AND DIMETHYLSULFIDE
- Author
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Daniel E. Anderson, Jessica Kong, William F. Melhado, Jared C. Whitman, and AnGayle K. Vasiliou
- Subjects
chemistry.chemical_compound ,chemistry ,Ethanethiol ,Radical ,Thermal decomposition ,Photochemistry ,Mechanism (sociology) - Published
- 2016
19. Corrigendum to ‘Effects of Delayed-release Dimethyl Fumarate (DMF) on Health-related Quality of Life in Patients With Relapsing-remitting Multiple Sclerosis: An Integrated Analysis of the Phase 3 DEFINE and CONFIRM Studies
- Author
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Robert J. Fox, Sarah Sheikh, Macaulay Okwuokenye, Gavin Giovannoni, J. Theodore Phillips, Sujata P. Sarda, Mariko Kita, Ludwig Kappos, Vissia Viglietta, Jessica Kong, and Ralf Gold
- Subjects
Pharmacology ,Health related quality of life ,Oncology ,medicine.medical_specialty ,Dimethyl fumarate ,business.industry ,Multiple sclerosis ,Delayed release (linguistics) ,medicine.disease ,chemistry.chemical_compound ,chemistry ,Relapsing remitting ,Internal medicine ,medicine ,Pharmacology (medical) ,In patient ,business - Published
- 2018
20. Effects of BG-12 (dimethyl fumarate) on health-related quality of life in patients with relapsing-remitting multiple sclerosis: findings from the CONFIRM study
- Author
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J. Theodore Phillips, Mariko Kita, Sujata P. Sarda, Michael Hutchinson, Robert J. Fox, Eva Havrdova, Katherine Dawson, Sarah Sheikh, Annie Zhang, Sonalee Agarwal, Vissia Viglietta, Emily Seidman, and Jessica Kong
- Subjects
Adult ,Male ,medicine.medical_specialty ,Dimethyl Fumarate ,Placebo ,law.invention ,chemistry.chemical_compound ,Multiple Sclerosis, Relapsing-Remitting ,Quality of life ,Randomized controlled trial ,Double-Blind Method ,Fumarates ,law ,Internal medicine ,Surveys and Questionnaires ,medicine ,Humans ,In patient ,Glatiramer acetate ,Dimethyl fumarate ,business.industry ,Multiple sclerosis ,Middle Aged ,medicine.disease ,Treatment Outcome ,Neurology ,chemistry ,Relapsing remitting ,Physical therapy ,Quality of Life ,Female ,Neurology (clinical) ,business ,Immunosuppressive Agents ,medicine.drug - Abstract
Multiple sclerosis (MS) has a significant impact on health-related quality of life (HRQoL) with symptoms adversely affecting many aspects of everyday living. BG-12 (dimethyl fumarate) demonstrated significant efficacy in the phase III studies DEFINE and CONFIRM in patients with relapsing–remitting MS. In CONFIRM, HRQoL was worse in patients with greater disability at baseline, and who relapsed during the study, and improved with BG-12 treatment. Mean Short Form-36 Physical Component Summary scores for BG-12 increased over 2 years and scores for placebo decreased. Coupled with clinical and neuroradiological benefits, these HRQoL results further support BG-12 as an effective oral treatment for relapsing MS.
- Published
- 2013
21. BG-12 effects on quality of life in relapsing–/INS;remitting ms patients: Integrated analysis of the Phase 3 DEFINE and CONFIRM studies
- Author
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Vissia Viglietta, Sarah Sheikh, Mariko Kita, Nuwan Kurukulasuriya, Gavin Giovannoni, Robert J. Fox, Sujata P. Sarda, R. Gold, Katherine Dawson, Ludwig Kappos, J.T. Phillips, and Jessica Kong
- Subjects
medicine.medical_specialty ,Quality of life (healthcare) ,Physical medicine and rehabilitation ,Neurology ,business.industry ,Phase (waves) ,medicine ,Neurology (clinical) ,business ,Developmental psychology - Published
- 2013
22. Effects of BG-12 on Quality of Life in Patients with Relapsing-Remitting Multiple Sclerosis: Findings from the DEFINE Study (P07.102)
- Author
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Ludwig Kappos, Katherine Dawson, Sarah Sheikh, Sonalee Agarwal, Douglas L. Arnold, Krzysztof Selmaj, Amit Bar-Or, Jessica Kong, Ralf Gold, and Gavin Giovannoni
- Subjects
medicine.medical_specialty ,Oral treatment ,business.industry ,Roche Diagnostics ,Quality of life (healthcare) ,Relapsing remitting ,Multicenter study ,Family medicine ,Medicine ,media_common.cataloged_instance ,In patient ,Data monitoring ,Neurology (clinical) ,European union ,business ,media_common - Abstract
Objective: To report the impact of BG-12 on patient quality of life (QoL) after 2 years9 treatment in the Phase 3 DEFINE study. Background In DEFINE, a randomized, double-blind, placebo-controlled, multicenter study that evaluated the efficacy and safety of BG-12 over 2 years in patients with relapsing-remitting multiple sclerosis (RRMS), BG-12 significantly reduced clinical relapses, disability progression, and magnetic resonance imaging measures of disease activity. Design/Methods: Patients aged 18-55 years with RRMS (McDonald criteria) and Expanded Disability Status Scale score of 0.0-5.0 were eligible for enrollment. Patients were randomized 1:1:1 to placebo or BG-12 240 mg twice (BID) or three times daily (TID). A Short Form (SF)-36 questionnaire measured patients9 health status and health-related QoL on 8 multi-item 100-point scales at baseline and 6, 12, and 24 months; higher scores indicated higher QoL. These scores were used to calculate the Physical Component Summary (PCS) and Mental Component Summary (MCS) scores. Results: Overall, 1234 patients enrolled and received study treatment. At 2 years, patients reported higher mean SF-36 PCS scores with BG-12 BID (43.4) and TID (44.2) versus placebo (41.9; P Conclusions: Together with the significant effects on clinical measures (reduced relapse risk, annualized relapse rate, and disability progression), the demonstrated benefits on patient-reported health-related QoL further supports a potential role for BG-12 as a valuable oral treatment option in RRMS patients. Supported by: Biogen Idec Inc. Disclosure: Dr. Agarwal has received personal compensation for activities with Biogen Idec Inc as an employee. Dr. Kappos has received research support from Acorda Therapeutics, Actelion, Allozyne, BaroFold, Inc., Bayer Pharmaceuticals Corporation, Bayhill Therapeutics, Biogen Idec, Boehringer Ingelheim Pharmaceuticals, Inc, Elan Corporation, Genmab, GlaxoSmithKline, Inc., Glenmark Pharma, Merck Serono, MediciNova, Novartis, Sanofi-Aventis Pharmaceuticals, Santhera Pharmaceuticals, Shire, Roche Diagnostics, Teva Neuroscience, UCB Pharma, Pfizer Inc, Swiss MS Society, Swiss National Research Foundation, European Union, Gianni Rubatto Foundation, Novartis and Roche Research Foundations. Dr. Gold has received personal compensation for activities with Bayer Pharmaceuticals Corporation, Biogen Idec, Merck Serono, Teva Neuroscience. Dr. Gold has received personal compensation in an editorial capacity for Therapeutic Advances in Neurological Disorders. Dr. Gold has received (royalty or license fee or contractual rights) payments from Biogen Idec. Dr. Gold has received research support from Bayer Pharmaceuticals Corporation, Biogen Idec, Merck Serono, Novartis and Teva Neuroscience. Dr. Arnold has received personal compensation for activities with Bayer Healthcare, Biogen Idec, Genentech, Inc., NeuroRx Research, Roche Diagnostics Corporation, Schering, Serono, Inc., and Teva Neuroscience. Dr. Arnold Dr. Arnold has received research support from Bayer Healthcare, Biogen Idec, Genentech, Inc., NeuroRx Research, Roche Diagnostics Corporation, Schering, Serono, Inc., and Teva Neuroscience. Dr. Bar-Or has received personal compensation for activities with Aventis Pharmaceuticals, Bayhill Therapeutics, Biogen Idec, Berlex Laboratories, Eli Lilly & Company, Genentech, Inc., GlaxoSmithKline, Ono Pharmaceutical, Diogenix, Roche Diagnostics Corporation, Merck Serono, Novartis, Teva Neuroscience. Dr. Giovannoni has received personal compensation for activities with Bayer-Pharmaceuticals Corporation, Biogen Idec, Five Prime Therapeutics, Inc, Genzyme Corporation, Ironwood Pharmaceuticals, Merck Serono, Novartis, Teva Neuroscience, Sanofi-Aventis Pharmaceuticals and Vertex Pharmaceuticals as a speaker, consultant and/or serving on data monitoring boards. Dr. Selmaj has received personal compensation for activities with Genzyme, Ono, and Biogen Idec. Dr. Kong has received personal compensation for activities with Biogen Idec as an employee. Dr. Sheikh has received personal compensation for activities with Biogen Idec as an employee. Dr. Dawson has received personal compensation for activities with Biogen Idec Inc. as an employee.
- Published
- 2012
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