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The global pandemic of COVID-19 has brought huge public health challenges to the world. To meet the challenge, researchers worldwide have carried out a series of clinical studies. This article aims to analyze the progress of COVID-19, and explore the development and main research directions in 2020. The clinical trials focus on the design of the trial plan, which can be registered on the platform after the design is completed. The purpose of clinical publications is to publish trial results, focusing on in vitro tests, drug screening and so on. Based on these characteristics, this paper analyzes both clinical publications and clinical trials, and explores the development of global clinical research in 2020 from countries, intervention methods and trial designs. The experimental results show that the United States and China have published the most publications and carried out the most clinical trials. The maximum intervention methods in clinical trials & publications are focused on the drugs.