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Abstract Background Megaoesophagus (ME), a disorder of the oesophagus characterized by diffuse oesophageal dilation and decreased peristalsis that may be congenital or acquired. Knowledge regarding the aetiology and prognosis for canine acquired ME is currently limited with most cases being idiopathic, which is a considerable problem to implement an appropriate treatment and a potential better prognosis. Case presentation A 7-year-old, neutered, female Spanish Water Dog was evaluated for progressive weight loss, chronic vomiting and regurgitation. The patient did not present other clinical signs. The contrast radiography in the cervical zone revealed oesophageal dilation. Eventually, the endoscopy revealed a marked dilation of the oesophagus. A surgery was conducted to insert a gastrotomy feeding tube. Initially, the patient response to this treatment was positive. However, the vomiting and regurgitation reappeared after 8 days. Due to the grim prognosis the owners elected to euthanize the patient. Necropsy revealed severe oesophageal dilation. The histopathological evaluation revealed moderate erosive catarrhal oesophagitis and gastritis. The skeletal muscular layer of the oesophagus showed moderate angular atrophy of some muscular fibres and a severe infiltrate of lymphocytes with marked tropism to autonomous neuronal bodies, some of which showed severe degenerative changes with absence of Nissl corpuscles, pyknotic nuclei and eosinophilic cytoplasm. The immunohistochemical study revealed that the majority of the infiltrate surrounding neuronal bodies were CD3 + T cells. These findings are consistent with an immune-mediated megaoesophagus. Conclusions To the best of our knowledge, this is the first report describing a lymphoplasmacytic infiltrate surrounding the oesophageal myenteric plexus in an adult dog with no other clinical signs or other myopathies. With these results, the authors hope to raise awareness in the diagnostic of canine ME and include an immune-mediated cause that lean to the establishment of appropriate treatment and improve prognosis of this condition.

Abstract Background The main objectives of the study were to analyse the use of the Objective Structured Clinical Examination (OSCE) to evaluate the skills of medical students in paediatric basic life support (PBLS), to compare two resuscitation training models and to evaluate the measures to improve the teaching program. Methods Comparative, prospective, observation study with intervention in two hospitals, one undergoing a PILS course (Paediatric Immediate Life Support) and another PBLS. The study was performed over three phases. 1º. PBLS OSCE in 2022 three months after the resuscitation training 2. Measures to improve the training program in 2023 3. PBLS OSCE in 2023. Overall results were analysed and comparison between both sites and those for 2022 and 2023 were made. Results A total of 210 and 182 students took part in the OSCE in 2022 and 2023, respectively. The overall mean score out of 100 was 83.2 (19), 77.8 (19.8) in 2022 and 89.5 (15.9) and 2023, P

Abstract To evaluate the hemodynamic effects and the safety profile of fluid bolus resuscitation with hypertonic saline albumin (HSA) in critically ill children, we performed a prospective observational pilot study between October 2018 and May 2021 in the pediatric intensive care unit (PICU) in a tertiary hospital in Madrid, Spain. Sixty-four HSA boluses were analyzed in 23 patients. A mean volume of 5.7 ml/kg (Standard Deviation, SD 2.3 ml/kg) per bolus was infused. Acute hypotension was the main indication. 91% of the patients had a cardiac disease, 56% of them had undergone cardiac surgery in the previous 72 h, and 47.8% associated right ventricular dysfunction. A significant increase in systolic, mean, and diastolic blood pressure and a decrease in the vasoactive index was observed after the infusion of HSA. This effect lasted for twenty-four hours (p

Animation has been employed as a productive and subtle means to represent Post-Traumatic Stress Disorder (PTSD) and historical trauma. The aim of this article is to study the narrative, visual, and psycho-affective strategies of both phenomena through the films Flee (Jonas Poher Rasmussen, 2021), Waltz with Bashir (Ari Folman, 2008), and L'Image Manquante (Rithy Panh, 2013). The ability of animated images to reconstruct moments for which there is no visual testimony, as well as their capacity to evoke the experience of traumatic events, emerges as the center of a specific aesthetic approach to history, forming a type of cinema of the real (Zylberman, 2022). Contrary to the tradition of documentary and visual essay, there is a more frequent expressive use of evocative mechanisms, dreamlike images combined with archival material, and forms of re-enactment of real events that necessarily do not involve the use of actors. The evocation of painful experiences establishes a visual framework in which the viewer becomes the epicenter of the affective staging of trauma and PTSD, prioritizing poetic construction.

In the majority of nations, environmental sustainability is an integral aspect of government policies, highlighting the criticality of equipping upcoming engineers with the necessary environmental awareness and skills to tackle this complex challenge. Higher education institutions assume a pivotal role in fulfilling this mission as their engineering programs aspire to generate graduates who possess the necessary competencies to effectively operate as “sustainable” engineers. Novel pedagogical methodologies, such as service learning, are currently being utilized to foster the cultivation of sustainable development values. Service-Learning represents a highly congruent approach to achieving Sustainable Development Goal (SDG) 4, insofar as it seamlessly integrates educational curricula with relevant community issues. As a result, it effectively contributes to the advancement of education for a sustainable future. This investigation sought to assess the impact of service learning projects developed in a rural school community on the boosting of social skills and environmental values among engineering students. The empirical evidence suggests that Service-Learning initiatives centered on environmental issues are efficacious in promoting the acquisition of social and environmental values among students. This, in turn, results in a positive transformation of their skill sets. Significantly, a substantial proportion of environmental engineering students who previously demonstrated a low awareness of these skills acknowledged their acquisition upon completion of the Service-Learning projects. Moreover, no less than 75% of the participants endorsed the attainment of each of the 11 competencies evaluated.

Con este artículo, tomando el caso de la ciudad de Madrid durante la dictadura franquista, queremos contribuir a la discusión en torno a las concepciones teóricas sobre urbanismo de zonas denominadas suburbiales y cómo se articulan con la planificación de políticas urbanas y de control social, sobre dichos espacios. A través de la revisión historiográfica y un trabajo de consulta en diferentes archivos, queremos mostrar cómo en la conceptualización, legislación y gestión en torno al “problema de la vivienda” de la capital española, la dictadura franquista acompañó políticas para el control espacial y social de la población de sus suburbios.

Resumen: Objetivo: Describir la demora diagnóstica del cáncer de mama en atención primaria e identificar las variables de las pacientes, del proceso asistencial y de la enfermedad que intervienen en la demora hasta el diagnóstico y el tratamiento. Diseño: Estudio retrospectivo con seguimiento en una cohorte de mujeres con cáncer de mama desde los primeros síntomas hasta el inicio del tratamiento. Emplazamiento: En total 24 consultas de medicina de familia con información tanto de atención primaria como hospitalaria. Participantes: Fueron evaluadas 446 mujeres (periodo 2014-2023). Mediciones principales: Características de las pacientes (edad, antecedentes y comorbilidad), del proceso asistencial (cribado, lugar de consulta y prioridad de derivación) y de la enfermedad (estadio, presentación y factores de riesgo). Entre los intervalos de tiempo se incluyeron, entre otros, «intervalo de atención primaria», «intervalo del sistema sanitario», «intervalo de diagnóstico» e «intervalo de tratamiento». Resultados: El valor medio del «intervalo de atención primaria» fue de 24,7 días (mediana: 16), el del «intervalo de atención hospitalaria», de 77,2 días (mediana: 68), y el del «intervalo del sistema sanitario», de 93,6 días (mediana: 83). Mediante regresión lineal múltiple se observó una duración significativamente inferior del «intervalo del sistema sanitario» en mujeres con derivación preferente, estadios avanzados, bulto en la mama como presentación y factores de riesgo. Conclusiones: La mayoría son diagnosticadas en estadios precoces en el centro de salud. La duración del «intervalo del sistema sanitario» es inferior en derivaciones preferentes, cuando la forma de presentación es bulto en la mama, con factores de riesgo y en estadios avanzados. Abstract: Objective: To describe the delay in the diagnosis of breast cancer in primary care and to identify the patient, care process and disease variables involved in the delay to diagnosis and treatment. Design: Retrospective study with follow-up of a cohort of women with breast cancer, from the first symptoms to the start of treatment. Site: In total 24 family medicine practices with information from both primary care and hospital settings. Participants: 446 women were evaluated (period 2014-2023). Main measurements: Patient characteristics (age, history and comorbidity), care process (screening, consultation site and referral priority) and disease characteristics (stage, presentation and risk factors) were included. Time intervals considered included, among others, «primary care interval», «health system interval», «diagnosis interval» and «treatment interval». Results: The mean value of the «primary care interval» was 24.7 days (median: 16); that of the «hospital care interval», 77.2 days (median: 68); and that of the «health system interval», 93.6 days (median: 83). Multiple linear regression showed a significantly shorter duration of the interval in women referred preferentially, in advanced stages, with a breast lump at presentation and with risk factors. Conclusions: Most are diagnosed in early stages at the health centre. The duration of the «health system interval» is shorter in preferential referrals, when the form of presentation is a breast lump, with risk factors and in advanced stages.

Abstract Specialization remains as a controversial and ambiguous term in ecology. Although it has been usually measured using a dichotomic and simplified classification of specialists and generalists, its nature is by far more complex. In the context of biotic interactions, assigning these two labels is usually based on the number of interacting partners (one or few vs. many). Here, we provide a more precise, quantitative, and objective interpretation of the specialization phenomenon combining three different dimensions (specificity, preference, and selectivity) that offer complementary information to quantify specialization. Hence, partner richness is a metric associated with the specificity, Simpson's evenness is related to the preference and d′ index to the selectivity of the biotic interactions. Consequently, we propose a 3D specialization space combining these three metrics which allows to identify the degree of biotic specialization fleeing from its simplified historical interpretation. The proposed space was subsequently evaluated in five natural interacting systems (host–parasite, plant–ant, plant–pollinator, plant–seed disperser, and mycobiont–cyanobacteria) using available data comprising 116 networks with quantitative observations. The results indicate the prevalence of a lax specialization, where most organisms tended to show low values in at least one of the metrics. Predominantly, observations showed high values of specificity and low values of preference and selectivity. This relaxed specialization provides advantages of being specialized, without sentencing it when being too tight. The implementation of this framework provides a useful tool that allows to identify specialization in a more objective, integrative, and universal way for future specialization studies.

Abstract Polycomb Repressive Complexes (PRCs) control gene expression through the incorporation of H2Aub and H3K27me3. In recent years, there is increasing evidence of the complexity of PRCs’ interaction networks and the interplay of these interactors with PRCs in epigenome reshaping, which is fundamental to understand gene regulatory mechanisms. Here, we identified UBIQUITIN SPECIFIC PROTEASE 5 (UBP5) as a chromatin player able to counteract the deposition of the two PRCs’ epigenetic hallmarks in Arabidopsis thaliana. We demonstrated that UBP5 is a plant developmental regulator based on functional analyses of ubp5-CRISPR Cas9 mutant plants. UBP5 promotes H2A monoubiquitination erasure, leading to transcriptional de-repression. Furthermore, preferential association of UBP5 at PRC2 recruiting motifs and local H3K27me3 gaining in ubp5 mutant plants suggest the existence of functional interplays between UBP5 and PRC2 in regulating epigenome dynamics. In summary, acting as an antagonist of the pivotal epigenetic repressive marks H2Aub and H3K27me3, UBP5 provides novel insights to disentangle the complex regulation of PRCs’ activities.

Image contrast enhancement is an essential process that improves the visibility of many features that may remain hidden due to low-contrast conditions arising from environmental causes, limitations of the device, or the wrong setting of the camera. This paper introduces a new technique of image contrast enhancement that combines insights from social sciences and image processing. In this model, the intensity of each pixel represents the opinion of an individual, and all the neighboring pixels interact by influencing each other. The algorithm operates to first increase the similarity of those pixels in the regions where pixels maintain similar intensities and, second, to amplify the differences in regions where differences exist. This process increases the contrast in regions with significant differences and reduces variation in uniform regions, hence enhancing clarity in the visual information and details of the image. The effectiveness and high performance of the proposed method are evaluated by a variety of experiments conducted on different image datasets using different quality indexes. The results obtained after experimentation highlight the superiority of the approach with respect to the state-of-the-art techniques of contrast enhancement.

Abstract This study focuses on the structural integrity analyses of a submersible cage with dimensions of 20 m in diameter and 10 m depth under extreme oceanographic conditions, including current speed of 0.5 and 1 m/s, combined with waves ranging from 2 to 5 m in height and a period of 7 s. Employing a dynamic simulation model based on finite elements, The study examines the stresses in the cage's pipes, as well as the tension in the bridle lines and mooring lines. Results indicate that submerging the cage leads to a reduction in peak tensions, with mooring lines experiencing a decrease of up to 32% and bridle lines experiencing a decrease of up to 59%. Furthermore, the stresses in the pipes exhibit a significant decline of up to 71.4%. These findings demonstrate that the submersible cage, when submerged, significantly reduces peak stresses, thereby decreasing the risk of structural loss or damage when the system is submerged.

Abstract In this paper, we study two singular maps, the Modern Map of Spain, attributed to Cardinal Margarit, and Spagna con le distantie de li loci; made in northern Italy in the late 15th and early 16th centuries. Like the British Gough map, both already show communication networks with expressed distances. Using formal analysis, statistical methodology, and computer processing, we present the cartographic characteristics of each one and relate them to their historical context, updating the scarce information available until now. We explain their relationship as two milestones of the same cartographic process. At the same time, we study the routes represented, finding out the units of measurement used and the communication networks that both maps show us in the context of the Revolution of Communications that the Renaissance represented in Europe. The research has allowed us to attribute a new dating to them, question the traditional authorship, and advance a theory on the transport networks’ functionality, demonstrating that both maps are part of a cartographic and historical process at the European level. All these updates to the vision on the first maps of communications in Western Europe established new contributions to the relationship between maps and itineraries. It contributes to filling a void occupied in solitary, until now, by the map of Gough of Great Britain.

Desde la década de los ochenta, la publicidad en España ha utilizado personajes del anime para promocionar productos licenciados o relacionados con la explotación comercial de sus personajes. Sin embargo, pese a que el consumo de manga y anime ha crecido enormemente en los últimos años, no se constata un crecimiento proporcional en el uso de estas narrativas en las campañas publicitarias dirigidas a anunciar productos o servicios de marcas ajenas al universo manganime. A este efecto, planteamos detectar qué elementos provocan la disincronía entre el aumento del consumo del anime y su constante ausencia en la creatividad publicitaria en España, concretamente, en campañas publicitarias de productos o servicios que no tienen relación directa con las series anime. Se propone una construcción interpretativa mediante la realización de un grupo focal con universitarios que ha posibilitado conocer sus reacciones respecto a las campañas publicitarias que sí han utilizado narrativa anime en otros países. Entre otros aspectos, los resultados reflejan la necesidad de entender el universo narrativo de los anime, sus personajes y subtexto. Del mismo modo, creemos que entre anime y marca debe existir coherencia estética y audiovisual y compartir valores para que el público lo acepte positivamente y no como un elemento intrusivo. Finalmente, se sustraen cuatro principales variables sobre las que poder desarrollar las campañas publicitarias basadas en narrativas del anime.

Introduction and objectives: No studies have analysed the effectiveness of treatment for constipation in critically ill children. The aim of this study was to assess the implementation, efficacy and safety of a treatment protocol using polyethylene glycol 3350 with electrolytes (PEG 3350 + E) for constipation in critically ill children. Methods: We conducted a single-centre prospective study in children admitted to the paediatric intensive care unit for a minimum of 72 h and who developed constipation. Children with previous gastrointestinal disorders or diseases were excluded. The patients were treated with rectal enemas or with the oral PEG 3350 + E protocol at the discretion of the treating physician. We compared clinical and demographic variables as well as adverse events (diarrhoea, abdominal distension and electrolyte imbalances). Results: The sample included 56 patients with a mean age of 48.2 ± 11.9 months, of who 55.4% were male. Forty-four patients (78.6%) were treated with PEG 3350 + E and 12 (21.4%) with rectal enemas. The proportion of patients that responded well to treatment was greater in the PEG 3350 + E group (79.5%) compared to the enema group (58.3%), but the difference was not statistically significant (P = .151). There were no significant differences between the groups in any of the adverse effects. Treatment with PEG 3350 + E was more effective in children aged less than 2 years (100%) compared to older children (100% vs 65.4%; P

Abstract A secondary analysis of a randomized study was performed to study the relationship between volumetric capnography (VCAP) and arterial CO2 partial pressure (PCO2) during cardiopulmonary resuscitation (CPR) and to analyze the ability of these parameters to predict the return of spontaneous circulation (ROSC) in a pediatric animal model of asphyxial cardiac arrest (CA). Asphyxial CA was induced by sedation, muscle relaxation and extubation. CPR was started 2 min after CA occurred. Airway management was performed with early endotracheal intubation or bag-mask ventilation, according to randomization group. CPR was continued until ROSC or 24 min of resuscitation. End-tidal carbon dioxide (EtCO2), CO2 production (VCO2), and EtCO2/VCO2/kg ratio were continuously recorded. Seventy-nine piglets were included, 26 (32.9%) of whom achieved ROSC. EtCO2 was the best predictor of ROSC (AUC 0.72, p < 0.01 and optimal cutoff point of 21.6 mmHg). No statistical differences were obtained regarding VCO2, VCO2/kg and EtCO2/VCO2/kg ratios. VCO2 and VCO2/kg showed an inverse correlation with PCO2, with a higher correlation coefficient as resuscitation progressed. EtCO2 also had an inverse correlation with PCO2 from minute 18 to 24 of resuscitation. Our findings suggest that EtCO2 is the best VCAP-derived parameter for predicting ROSC. EtCO2 and VCO2 showed an inverse correlation with PCO2. Therefore, these parameters are not adequate to measure ventilation during CPR.

El objetivo general de esta investigación es comprobar el impacto de una intervención en alumnos con Trastorno del Espectro Autista (TEA) desde dos perspectivas diferentes, tradicional e innovadora con realidad aumentada (RA) y virtual (RV). Se trata de un estudio de investigación cuantitativo con un diseño cuasi-experimental pretest-postest en un mismo grupo de sujetos. Se establecieron dos tipos de variables, la acción formativa desplegada (enfoque tradicional y RA-RV) y el efecto causado en las distintas dimensiones presentadas (motivación, atención, comunicación, autonomía y resultados de aprendizaje). La muestra estuvo formada por 23 personas con TEA, con una edad media de 10,52 años. Se concluye que el diseño y la adaptación de las tecnologías a las necesidades individuales de los alumnos con TEA son importantes. La comorbilidad puede afectar a los resultados del aprendizaje en los enfoques tradicionales, pero no en los innovadores. El uso adecuado y equilibrado de la RA y la RV puede maximizar los beneficios y minimizar los posibles efectos negativos para los alumnos con TEA.

Abstract Ba0.85Ca0.15Zr0.1Ti0.9O3 (BCZT) stands out among lead‐free ferroelectric oxides under consideration to replace state‐of‐the‐art high‐sensitivity piezoelectric Pb(Zr,Ti)O3, for a range of energy conversion ceramic technologies. However, the best performances have been reported for very coarse‐grained materials, and attempts to refine microstructure below 10 µm grain size consistently result in significant property degradation. Here a comprehensive study of the grain size effects on the properties of BCZT across the micron scale is reported, down to the verge of the submicron one. Results show a distinctive early evolution of properties for grain sizes between 1 and 5 µm. For the larger sizes in this range, an opposite effect is found for the piezoelectric charge coefficient and electric field‐induced strain with respect to the very coarse‐grained material, while very good overall performance is maintained. For the lower sizes, relaxor features appear, yet materials can still be poled indicating their ferroelectric nature. This strongly resembles size effects in the Pb(Mg1/3Nb2/3)O3‐PbTiO3 system, driven by the slowing down of the relaxor to ferroelectric transition with size reduction, though kinetics seem to slow down across much larger grain sizes for BCZT. Concomitant changes in the polymorphic phase coexistence are described and discussed by synchrotron X‐ray diffraction.

BackgroundIn people living with HIV (PLHIV), the CD4/CD8 ratio has been proposed as a useful marker for non-AIDS events. However, its predictive ability on mortality over CD4 counts, and the role of CD8+ T-cell counts remain controversial.MethodsWe conducted a systematic review and meta-analysis of published studies from 1996 to 2023, including PLHIV on antiretroviral treatment, and reporting CD4/CD8 ratio or CD8+ counts. The primary outcome was non-AIDS mortality or all-cause mortality. We performed a standard random-effects pairwise meta-analysis comparing low versus high CD4/CD8 ratio with a predefined cut-off point of 0.5. (CRD42020170931).FindingsWe identified 2,479 studies for screening. 20 studies were included in the systematic review. Seven studies found an association between low CD4/CD8 ratio categories and increased mortality risk, with variable cut-off points between 0.4-1. Four studies were selected for meta-analysis, including 12,893 participants and 618 reported deaths. Patients with values of CD4/CD8 ratio below 0.5 showed a higher mortality risk (OR 3.65; 95% CI 3.04 - 4.35; I2 = 0.00%) compared to those with higher values. While the meta-analysis of CD8+ T-cell counts was not feasible due to methodological differences between studies, the systematic review suggests a negative prognostic impact of higher values (>1,138 to 1,500 cells/uL) in the long term.ConclusionsOur results support the use of the CD4/CD8 ratio as a prognostic marker in clinical practice, especially in patients with values below 0.5, but consensus criteria on ratio timing measurement, cut-off values, and time to event are needed in future studies to get more robust conclusions.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020170931, identifier CRD42020170931.

This work introduces a methodology for the design of X-band microwave absorbers using carbon-graphite powder composites. The reflection loss (RL) is adjusted through variations in sample thickness, mono/bi-slab geometries, and effective dielectric constant. The impact of the particle size of the powders and the volume fraction (v.f.) of the composites on the effective dielectric permittivity has been systematically investigated. The Nicolson-Ross-Weir (NRW) conversion and the Birchak dielectric mixing model were employed. Optimal absorption conditions predicted by RL simulations were validated through experimental waveguide measurements for mono/bi-slab systems of paraffin-carbon composite samples. The mono-slabs with a particle size of 3.5 μm showed the best versatility for tailoring the RL in the X-band through v.f. variations while maintaining a fixed thickness of 2 mm. In addition, a bi-slab system (powder-paraffin/paraffin) for such powder size, at 18.0 % of v.f., showed an enhanced RL with a bandwidth of 2.6 GHz and a minimum of − 40 dB (at 11 GHz). Other dielectrics based on resin:paint mixtures were tested to replace the paraffin-matrix, revealing a strong powder-matrix interaction capable of modulating the effective dielectric permittivity. Finally, experimental antenna RL measurements conducted in free space were corroborated by theoretical simulations based on the waveguide characterizations.

Human health hazards appear in wine production. Wineries have implemented food safety management systems to control food hazards through Hazard Analysis Critical Control Point (HACCP). Wine-making industry applies HACCP by evaluating Critical Control Points (CCPs). One of the CCPs that exhibits inadequate control is the potential contamination risk of arsenic, cadmium, and lead throughout the winemaking procedure. Wineries performance level about controlling CCPs related to contamination risk by arsenic, cadmium and lead in the winemaking were analyzed. A sixteen-question questionnaire was made to achieve this research. Three indicators were calculated for training, legislation, and analysis performance components in CCPs control. Results revealed that wineries fault in analysis and legislation components. Identification and updating of legislation about As, Cd and Pb contamination risk is in starting performance level for wineries that produce less than 250,000 L/year wineries. Analysis performance level is even lower than legislation. Only one out of every three wineries possess information regarding the concentrations of arsenic, cadmium, and lead in the soils of vineyards where grapes are cultivated. Furthermore, the availability of data on their available concentrations in the soil solution is even more limited. Those wineries that controlled As, Cd and Pb concentrations make it according to official recommendations using techniques based on atomic absorption spectrometry. However, there is a lack of this spectrometry equipment in the wineries own laboratories.

Abstract Purpose To assess the effectiveness and safety of acupuncture for the prevention of chemotherapy‐induced nausea and vomiting (CINV), with a specific intention on exploring sources of between‐study variation in treatment effects. Methods MEDLINE, EMBASE, Cochrane CENTRAL, CINAHL, Chinese Biomedical Literature Database, VIP Chinese Science and Technology Periodicals Database, China National Knowledge Infrastructure, and Wanfang were searched to identify randomized controlled trials (RCTs) that compared acupuncture to sham acupuncture or usual care (UC). The main outcome is complete control (no vomiting episodes and/or no more than mild nausea) of CINV. GRADE approach was used to rate the certainty of evidence. Results Thirty‐eight RCTs with a total of 2503 patients were evaluated. Acupuncture in addition to UC may increase the complete control of acute vomiting (RR, 1.13; 95% CI, 1.02 to 1.25; 10 studies) and delayed vomiting (RR, 1.47; 95% CI, 1.07 to 2.00; 10 studies) when compared with UC only. No effects were found for all other review outcomes. The certainty of evidence was generally low or very low. None of the predefined moderators changed the overall findings, but in an exploratory moderator analysis we found that an adequate reporting of planned rescue antiemetics might decrease the effect size of complete control of acute vomiting (p = 0.035). Conclusion Acupuncture in addition to usual care may increase the complete control of chemotherapy‐induced acute vomiting and delayed vomiting but the certainty of evidence was very low. Well‐designed RCTs with larger sample sizes, standardized treatment regimens, and core outcome measures are needed.

Introduction: Hip fractures pose a significant challenge for older individuals given their high incidence and one-year mortality rate. The objective of this study was to identify the primary predictors of one-year mortality in older adults hospitalized for hip fractures. Methods: We conducted a retrospective cohort study involving adults aged 70 years or older who were admitted to the hospital for fragility hip fractures between 1 January 2014 and 31 December 2021. A total of 3229 patients were recruited, with 846 (26.2%) experiencing one-year mortality. Results: Respiratory complications (HR 2.42, 95%CI 1.42–4.14; p = 0.001) were the most significant predictors of one-year mortality, followed by hospital readmission (HR 1.96, 95%CI 1.66–2.32; p < 0.001), the male sex (HR 1.88, 95%CI 1.46–2.32; p < 0.001), cardiac complications (HR 1.88, 95%CI 1.46–2.32; p < 0.001), and a diagnosis of dementia at admission (HR 1.37, 95%CI 1.13–1.66; p = 0.001). The Charlson Index and the American Society of Anesthesiologists physical status classification system also significantly increased the mortality risk. Conversely, higher hemoglobin levels at admission and elevated albumin at discharge significantly reduced the mortality risk. Conclusions: The one-year mortality rate is substantial in older adults with hip fractures who are admitted to an orthogeriatric unit. The appropriate management of anemia, nutritional disorders, and comorbidity at admission and during the follow-up could potentially mitigate long-term mortality after hip fractures.

Esta investigación aborda el estudio de los procesos de integración de Brasil. El trabajo se inicia con un estudio del proceso constituyente brasileño con especial interés por la Constitución de 1988 y su desarrollo democrático. Posteriormente se estudia la afectación de los poderes constitucionales de Brasil ante la firma de un acuerdo de libre comercio, incidiendo en diversas integraciones en las que ha participado este país como Mercosur o las alianzas con la Unión Europea y Estados Unidos. El artículo reflexiona sobre el crecimiento de los países de América Latina, destacando cómo los acuerdos de libre comercio se han convertido en un instrumento para desarrollar alianzas políticas internacionales. También se investigan los mecanismos de resolución de conflictos entre países y los controles jurisdiccionales en los tratados internacionales.

El mundo actual se encuentra condicionado no solo por la pandemia derivada de la COVID-19, sino por la facilidad e inmediatez de la información en diversos formatos. En su vertiente escrita, para ser procesada la información, necesita de una lectura previa por parte de las personas. Por ello, la lectura se alza como una habilidad fundamental en la vida social y académica de las personas. Este aspecto se fomenta en los centros educativos por medio de diversas prácticas recogidas en un documento oficial denominado Plan Lector. Los objetivos del presente estudio se centran en conocer la influencia de dicho plan en la motivación, la inteligencia emocional, la fluidez y comprensión lectora del alumnado de educación primaria. Para alcanzar estos objetivos se ha propuesto un diseño de investigación cuasi-experimental de tipo pre-post fundamentado en una metodología cuantitativa. En el estudio han participado 114 estudiantes de educación primaria de un centro educativo de Ceuta (España). La recogida de datos se ha llevado a cabo mediante tres instrumentos validados (Cuestionario de Estrategias Motivadas para el Aprendizaje, Inventario de Inteligencia Emocional de BarOn y el EMLE-TALE 2000). Los resultados revelan que las acciones desplegadas en el plan lector del centro educativo han supuesto mejoras en la fluidez y comprensión lectora. Sin embargo, las actuaciones realizadas no han mejorado la motivación ni la inteligencia emocional de los discentes.

Flipped learning has emerged as a method that can facilitate practical learning supported by technology. This study analyzes the impact of the flipped approach on students’ learning of prevention guidelines and socio-health regulations related to the COVID-19 pandemic. A total of 585 Spanish secondary education students participated, and three validated instruments were used to obtain information about their self-regulation, social competence, and decision-making. The results showed that the average scores achieved by all groups, both in the pre-test and the post-test measures, were similar, except those achieved by the experimental post-test group, where the average scores were higher than the rest. The study concludes that both traditional and flipped learning pedagogical applications for training students in the measures to prevent COVID-19 generate knowledge and improved skills. Theoretical and practical implications are discussed, including the insight that active teaching methods promote greater improvement in student learning than traditional, expository methods.

The unlubricated wear behaviour of a very recently developed ZrB2–hardened Zr3Al2 intermetallic–ceramic composite was investigated for the first time. In particular, tribological tests of scratch, fretting, and sliding were performed with no external lubrication under varied loads against diamond counterparts to thus account for different types and conditions of frictional contacts, and the worn surfaces were characterised in detail to identify the corresponding wear modes and mechanisms. It was found that under scratch wear the Zr3Al2–ZrB2 composite undergoes a ductile-to-brittle transition with increasing applied load, with an increasing plastic damage from low loads and eventually also with macro-chipping at intermediate loads and massive meso-/macro-chipping at high loads. It was also found that the Zr3Al2–ZrB2 composite is resistant to both fretting wear and sliding wear, exhibiting low specific wear rates. Thus, under fretting wear it underwent mild damage first by fretting fatigue in the form of slight surface abrasion and then by fretting oxidation with formation of a self-lubricating oxide tribolayer. The severities of the fretting fatigue and fretting oxidation increased with increasing applied load, with the former dominating over the latter for low and intermediate loads and the opposite being the case for high loads. Similarly, under sliding wear it also underwent only mild damage, now first by mechanical sliding wear and then by oxidative sliding wear, both of increasing severity with increasing applied load, but with the abrasion dominating over the oxidation. Given the promising wear behaviour observed in this first tribological study against diamond, it is proposed that these Zr3Al2–ZrB2 composites merit further investigation under an ample set of possible engineeringly-relevant wear conditions.

Abstract Background Masitinib is an orally administered tyrosine kinase inhibitor that targets activated cells of the neuroimmune system (mast cells and microglia). Study AB09004 evaluated masitinib as an adjunct to cholinesterase inhibitor and/or memantine in patients with mild-to-moderate dementia due to probable Alzheimer’s disease (AD). Methods Study AB09004 was a randomized, double-blind, two parallel-group (four-arm), placebo-controlled trial. Patients aged ≥50 years, with clinical diagnosis of mild-to-moderate probable AD and a Mini-Mental State Examination (MMSE) score of 12–25 were randomized (1:1) to receive masitinib 4.5 mg/kg/day (administered orally as two intakes) or placebo. A second, independent parallel group (distinct for statistical analysis and control arm), randomized patients (2:1) to masitinib at an initial dose of 4.5 mg/kg/day for 12 weeks that was then titrated to 6.0 mg/kg/day, or equivalent placebo. Multiple primary outcomes (each tested at a significance level of 2.5%) were least-squares mean change from baseline to week 24 in the Alzheimer’s Disease Assessment Scale - cognitive subscale (ADAS-cog), or the Alzheimer’s Disease Cooperative Study Activities of Daily Living Inventory scale (ADCS-ADL). Safety for each masitinib dose level was compared against a pooled placebo population. Results Masitinib (4.5 mg/kg/day) (n=182) showed significant benefit over placebo (n=176) according to the primary endpoint of ADAS-cog, −1.46 (95% CI [−2.46, −0.45]) (representing an overall improvement in cognition) versus 0.69 (95% CI [−0.36, 1.75]) (representing increased cognitive deterioration), respectively, with a significant between-group difference of −2.15 (97.5% CI [−3.48, −0.81]); p

Introduction: Tracheal intubation is a frequent procedure in paediatric intensive care units (PICUs) that carries a risk of complications that can increase morbidity and mortality. Patients and methods: Prospective, longitudinal, observational study in patients intubated in a level III PICU between January and December 2020. We analysed the risk factors associated with failed intubation and adverse events. Results: The analysis included 48 intubations. The most frequent indication for intubation was hypoxaemic respiratory failure (25%). The first attempt was successful in 60.4% of intubations, without differences between procedures performed by staff physicians and resident physicians (62.5% vs 56.3%; P = .759). Difficulty in bag-mask ventilation was associated with failed intubation in the first attempt (P = .028). Adverse events occurred in 12.5% of intubations, and severe events in 8.3%, including 1 case of cardiac arrest, 2 cases of severe hypotension and 1 of oesophageal intubation with delayed recognition. None of the patients died. Making multiple attempts was significantly associated with adverse events (P < .002). Systematic preparation of the procedure with cognitive aids and role allocation was independently associated with a lower incidence of adverse events. Conclusions: In critically ill children, first-attempt intubation failure is common and associated with difficulty in bag-mask ventilation. A significant percentage of intubations may result in serious adverse events. The implementation of intubation protocols could decrease the incidence of adverse events. Resumen: Introducción: La intubación traqueal es un procedimiento frecuente en las unidades de cuidados intensivos pediátricos con riesgo de complicaciones que pueden aumentar la morbimortalidad. Pacientes y métodos: Estudio descriptivo y analítico de una cohorte prospectiva incluyendo a los pacientes intubados en una UCIP de tercer nivel entre enero y diciembre de 2020, analizando los factores asociados con el fracaso de intubación y los efectos adversos. Resultados: Se analizaron 48 intubaciones. La indicación más frecuente fue el fallo respiratorio hipoxémico (25%). El primer intento de intubación fue exitoso en el 60,4%, sin diferencias entre los médicos adjuntos 62,5% y los residentes 56,3%, p = 0,759. La dificultad en la ventilación con bolsa y mascarilla se asoció con el fracaso del primer intento de intubación (p = 0,028). Se objetivaron eventos adversos en un 12,5% de las intubaciones, siendo graves en un 8,3% de los casos, incluyendo una parada cardiorrespiratoria, dos casos de hipotensión grave y una intubación esofágica detectada de forma tardía. Los intentos múltiples de intubación se asociaron significativamente con la aparición de eventos adversos (p

Resumen: Introducción: La intubación traqueal es un procedimiento frecuente en las unidades de cuidados intensivos pediátricos con riesgo de complicaciones que pueden aumentar la morbimortalidad. Pacientes y métodos: Estudio descriptivo y analítico de una cohorte prospectiva que incluye a los pacientes intubados en una unidad de cuidados intensivos pediátricos de tercer nivel entre enero y diciembre de 2020, analizando los factores asociados con el fracaso de intubación y los efectos adversos. Resultados: Se analizaron 48 intubaciones. La indicación más frecuente fue el fallo respiratorio hipoxémico (25%). El primer intento de intubación fue exitoso en el 60,4%, sin diferencias entre los médicos adjuntos y los residentes (62,5 vs. 56,3%; p = 0,759). La dificultad en la ventilación con bolsa y mascarilla se asoció con el fracaso del primer intento de intubación (p = 0,028). Se objetivaron eventos adversos en un 12,5% de las intubaciones, siendo graves en un 8,3% de los casos, incluyendo una parada cardiorrespiratoria, 2 casos de hipotensión grave y una intubación esofágica detectada de forma tardía. Ninguno de los pacientes falleció. Los intentos múltiples de intubación se asociaron significativamente con la aparición de eventos adversos (p

AbstractAmong the different tools that can be used in the implementation of flipped learning, learning management systems stand out as one of the educational technology systems that best solve problems related to usability, accessibility, and evaluation. The objective of this study is to analyze the academic impact of flipped learning through LMS platforms versus the use of flipped learning in other non-interactive digital media, as traditional learning. For this, a quasi-experimental design was used in a sample of 231 Spanish secondary school students. A questionnaire was used to collect the data. The results show that students who have followed the teaching-learning process with flipped learning obtain better results than those who only apply the flipped learning method. It is concluded that the use of an LMS during the application of the flipped learning methodology contributes to an optimization of the general teaching-learning process.

(1) Background: The aim is to ascertain health science students’ attitudes towards tattoos and their association with healthy lifestyles and socio-demographic variables. (2) Methods: Descriptive study conducted on pharmacy, medical and nursing students (n = 423). To ascertain attitudes towards tattoos, we used the Attitudes Towards Tattoos Scale. Other variables were physical activity, healthy diet, harmful habits and socio-demographic variables. (3) Results: A total of 12.6% (95% CI 9.1–16.2) of students reported having a tattoo; 58.9% did not regard tattoos as a health risk. In terms of attitudes, the mean score in the range of 7–35 (7—most unfavourable to 35—most favourable) was 22.6 (SD 5.2; 95% CI: 22.0–23.2). Scores were higher (p < 0.05) among women (23.1; SD: 5.3), persons aged p < 0.05) in nursing students than in pharmacy or medical students. No relationship was observed with physical activity, healthy diet or drug use. (4) Conclusions: The attitude to tattoos is most favourable among women, persons aged under 20 years and nursing students. In terms of health habits, attitudes are more favourable among smokers, regardless of their level of physical activity, compliance with healthy eating guidelines or consumption of alcohol or other drugs.

Virtual Learning Environments (EVA) have acquired special importance in the educational field in recent years. The metaverse has been constructed as a learning space with enormous potential. As such, the immersion possibilities of the metaverse increase when compared to other methodologies that already implement technology, such as flipped learning and e-learning. In these learning environments, students require a set of specific abilities and skills. Therefore, this study aims to understand which training approach (flipped learning or e-learning) helps students acquire better skills through a teaching and learning process in the metaverse. This thesis used a pre-post quasi-experimental design of a group containing 173 Spanish high school students to achieve its aim. The data collection has been carried out by the Teaching and Learning Experiences Questionnaire (ETLQ). Among the obtained results, it is discovered that in all the dimensions analyzed, a significant relationship is observed. The greatest difference in means occurs in the LO dimension, meaning that these educational experiences directly impact the student’s academic results. It is concluded that both training approaches are adequate in preparing students for training processes carried out in the metaverse since they complement each other. Therefore, as preliminary instruction, the sequential use of these approaches is necessary when familiarizing students with a new learning reality such as the metaverse. Doi: 10.28991/ESJ-2022-SIED-013 Full Text: PDF

A powder metallurgy route combining high-energy ball-milling (HEBM) of elemental powders and reactive spark-plasma sintering (SPS) is proposed for the controlled fabrication of novel composites based on a Zr–Al intermetallic matrix hardened with a ceramic second-phase. As proof-of-concept, its suitability is demonstrated on ZrB2–hardened Zr3Al2. Specifically, commercially available powders of ZrH2, Al, and B were first combined in molar ratios of 2:1:1 to give an intermetallic–ceramic composite nominally formed by ∼76.8 vol.% Zr3Al2 plus 23.2 vol.% ZrB2, and were intimately mixed and mechanically activated by HEBM in the form of dry shaker milling for 30 min, next identifying by a dilatometric SPS test at 50 MPa pressure that the densification window of these composites is ∼975–1275 °C. Subsequent densification SPS tests at 50 MPa pressure in that temperature interval, and also at 1350 °C, plus the microstructural and mechanical characterisations of the resulting materials, established 1175 °C as the optimal SPS temperature. It was also identified that densification takes place by transient liquid-phase sintering with molten Al, and that it occurs gradually, not abruptly, because most molten Al disappears in a flash by reacting with Zr to form in situ the intermetallic. It is also shown that the combination of HEBM plus reactive SPS yields Zr3Al2+ZrB2 composites with fine-grained microstructures formed essentially by multitudinous ZrB2 nanograins dispersed within a matrix of submicrometre, or nearly submicrometre, Zr3Al2 grains. Importantly, these intermetallic–ceramic composites were found to be very hard (i.e., ∼11.5 GPa), attributable to the hardening provided by the ZrB2 nanograins, and fairly tough (i.e., ∼4.5 MPa·m1/2), and therefore potential candidate materials for a multitude of structural–tribological applications. Finally, implications for future study are discussed.

In this paper, we conduct a statistical procedure to respond a very frequent question in Mexican sport media TV: Who is the greatest team in Liga MX? For this purpose, we apply Principal Components to a historical domestic and international results database along with variables related to the fans and the market value of the franchises’ roster from 2011-2019. The results allow us to analyze the evolution of the “greatness” latent variable over time, concluding that, in the window of time analyzed, Club América is the greatest team, followed by C.D. Guadalajara and C.F. Cruz Azul. Additionally, nowadays, Club Tigres de la Universidad Autónoma de Nuevo León and C.F. Monterrey displace teams like Deportivo Toluca F.C. and Club Universidad Nacional.

Inteligencia artificial, ChatGTP y OpenAI son algunos de los términos más buscados en Google en la actualidad según Google Trends (2023). Sin embargo, parte de la concepción de la inteligencia artificial y, sobre todo, de sus posibles aplicaciones tecnológicas en la robótica avanzada, derivan de imaginarios sociales y culturales que se han construido gracias a su representación en la literatura, el cine, las series y los videojuegos. Concretamente, en el cine, películas como Blade Runner (Scott, 1984), Terminator (Cameron, 1984), AI: Artificial Intelligence (Spielberg, 2001), I, Robot (Proyas, 2004) o Ex-Machina (Garland, 2014) han proyectado la imagen de robots inteligentes como amenaza o alteridad al ser humano. El objetivo de este manuscrito es comparar el discurso de las películas españolas Eva (Maíllo, 2011) y Autómata (Ibáñez, 2014) frente al discurso científico de las 20 películas más valoradas según IMDB que incluyen la temática de inteligencia artificial. Para ello, se han triangulado tres perspectivas: el mito de Prometeo (Nieto, 2022), los principios de mitología robótica (Pérez, 2004) y la dicotomía humano - no humano (Gastaka e Iturregi, 2022), lo que ha permitido, siguiendo la metodología de Novoa et al. (2019), extrapolar las características y rasgos que definen el discurso científico de la IA en la cinematografía para poder analizar así el discurso de ambas películas españolas. Los resultados permiten concluir que no existen discrepancias entre la ciencia ficción nacional y la internacional respecto al posicionamiento de la IA como el fin de la humanidad y el diseño de sociedades distópicas y apocalípticas, aunque, particularmente, Eva y Autómata ponen a debate temas éticos y antropológicos desde diferentes prismas acerca de la ética en la robótica y la alteridad, lo que permite avivar el debate sobre la capacidad de sentir de robots y androides frente al imaginario colectivo.

The Farm to Fork (F2F) Strategy, a key initiative of the European Commission under the European Green Deal, strives to make the European Union’s (EU) economy sustainable. Focused on the food system, the F2F Strategy prioritizes sustainability in agriculture, eco-friendly practices, biodiversity preservation, and climate change mitigation. It targets high food safety (FS) and environmental management (EM) standards across the Agri-food Supply Chain (ASC). Addressing sustainability challenges in the wine industry, this study delves into the Wine Value Chain (WVC). Emphasizing the intricate sustainability interplay within the WVC, this study concentrates on FS and EM to ensure the long-term viability of wine production. The primary goal is to create a comprehensive sustainability evaluation method for wineries, incorporating performance indicators from FS and EM components. The methodology involves assessing Food Safety Management Systems (FSMSs), evaluating Environmental Management Systems (EMSs), investigating contamination risks, and synthesizing results into a sustainability matrix. Findings highlight commendable FS practices, such as widespread Hazard Analysis and Critical Control Point (HACCP) adoption and underscore the need for increased EM focus. Notable figures include a 76.2% adoption of the HACCP system and 68.8% of wineries implementing an EMS. Performance indicators become critical for sustainability assessment, forming the cornerstone to gauge the industry’s effective sustainability management aligned with the F2F Strategy. This study stresses the holistic integration of FS and EM practices, providing insights into workforce engagement, regulatory compliance, and sustainable objectives. This research offers a tool for evaluating and advancing sustainability in the wine industry culminating in a sustainability matrix.

The latest advances in technology and materials science have catalyzed a transformative shift towards the adoption of environmentally conscious and lightweight materials across key sectors such as aeronautics, biomedical, and automotive industries. Noteworthy among these innovations are the magnesium-aluminum (Mg-Al) alloys employed in aeronautical applications, contributing to the overall reduction in aircraft weight and subsequently diminishing fuel consumption and mitigating atmospheric emissions. The present work delves into a study of the anti-corrosive properties inherent in various sol-gel coatings, leveraging a range of environmentally friendly corrosion inhibitors, specifically tailored for samples of the AZ61 alloy. Methodologically, the work involves the synthesis and application of sol-gel coatings on AZ61 alloy containing eco-friendly inhibitors: L-cysteine, N-acetyl-cysteine, curcumin and methylene blue. Subsequently, an accelerated corrosion test in a simulated saline environment is performed. Through microstructural and compositional analyses, the best inhibitors responses are achieved with inhibitors containing S, N heteroatoms and conjugated double bonds in their structure, probably due to the creation of a continuous MgCl2 layer. This research contributes to the ongoing discourse on protective eco-coatings, aligning with the broader paradigm shift towards sustainable and lightweight materials in key industries.

The demand for professionals entering the labor market requires knowledge and disciplines in the areas of Science, Technology, Engineering, Art and Mathematics (STEAM). Schools are the first link to train competent students for today’s society. However, the pandemic has conditioned the teaching–learning methodologies based on promoting STEAM in educational centers, which is the reason that leads us to carry out this study. The main objective of the research is to evaluate the STEAM dimensions in the sixth grade of primary education in times of pandemic. The study method is based on a quasi-experimental, descriptive and correlational design with an experimental group and a control group. The data are collected through a validated questionnaire, pre-test and post-test, which develops an assessment of student collaboration in STEAM activities. The sample is made up of 142 Spanish students, of which 68 belong to the control group and 74 to the experimental group. The conclusions of the study highlight that the active methodologies, based on computational thinking and on makerspaces of the future classroom, influenced the STEAM dimensions of the experimental group before the pandemic. However, the pandemic and the health restrictions in face-to-face classes led to a negative assessment of the experimental group in the STEAM dimensions.

Satellite-based precipitation products and reanalysis precipitation products have the potential to overcome the lack of information in regions where there are no or insufficient rain gauges to achieve any hydrological study. The Google Earth Engine (GEE) data analysis platform has products in its repository with global coverage that offers different geospatial information capable of measuring the amount of precipitation. However, it is necessary to evaluate the reliability of the products. There are precipitation information biases in Mexico due to the scarce presence of gauging stations, failed operations, access difficulty, and data capture errors. This study evaluates the reliability of satellite and reanalysis precipitation products hosted in the GEE repository against rain gauge observation from 2001 to 2017 using data from 4,658 stations over Mexico. The evaluation was carried out using statistical indicators comparing the behavior across different topographic, climatic, and temporal conditions. The results exhibit that the performance of the products hosted in GEE seems to depend on elevation conditions for other climatic regions in Mexico. The results show that all products can capture the general precipitation patterns at annual, seasonal, and monthly scales; however, the accuracy of the product is clearly lower at a daily scale. All products are highly biased on low precipitation events. HIGHLIGHTS The intensity and distribution of precipitation in Mexico depends on topography and climatic regions.; ERA5 product in Mexico showed the lowest correlations of the entire region, while CHIRPS is the product with the best score.; There is a more significant correlation of products in the regions and seasons with the highest presence of rainfall.;

Gamification is a training model that encourages the inclusion of active methodologies into learning environments. The objective of this study is to analyze the effects of a gamified experience through virtual and face-to-face escape rooms as well as to determine the generated levels of fun, absorption, creative thinking, mastery, activation, absence of negative effects and student grades. A descriptive and correlational experimental design has been used. In total, 105 Spanish university students participated. The data was collected using a scale validated in the Spanish context called Gameful Experience in Gamification (GAMEX). The results reveal significant variability according to the training environment. In face-to-face environments, students’ fun and activation were promoted, generating pleasant entertainment experiences. In virtual environments, influence, autonomy, creativity, and exploration by students increased. Similarly, these environments shared high levels of spatio-temporal absorption and an absence of negative effects. Regarding the ratings, no statistically significant results that confirm their effectiveness depending on the environment were determined, but good scores were obtained. It is concluded that the choice of the gamified environment will depend on the dimensions and the goals that the teacher intends to achieve during the learning process.

Con la presentación de los documentos reunidos aquí, identificados hace algunos años entre los fondos de una eminente institución pública, se tiene conocimiento de la gestación del “famoso” tabernáculo, de la mesa de altar y de la sillería del coro de la iglesia parroquial de San Juan Bautista de la villa toledana de Consuegra, diseñados en Madrid, en el último tercio del siglo XVIII, por el arquitecto Juan de Villanueva, así como de los cuadros que aún hoy presiden el testero del templo, atribuidos, hasta ahora, a los pintores Antonio Martínez Espinosa y José Beratón, además de otros trabajos de su interior.