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Introduction: SRIF was described as changes in lung parenchyma (hyalinized interstitial fibrosis, alveolar septal thickening, emphysema and respiratory bronchiolitis-RB) in lobectomy specimens from smokers with cancer and eventually by HRCT (ground-glass attenuation, reticulation and thick-walled cysts without traction bronchiectasis or parenchymal distortion) Objectives: To describe a group of SRIF patients as associated with interstitial lung disease (ILD) and/or emphysema Methods: Retrospective study on SRIF patients diagnosed in ILD consult since 2016 by HRCT. The variables included:age, sex, smoking habit, HRCT findings, spirometry, DLCO, pulmonary biopsy and diagnosis Results: 30 patients (28 ♂,2 ♀); mean age 69; 80% ex-smokers, 20% current smokers. All underwent HRTC with findings of SRIF and another ILD in most cases (Table 1). Spirometry pattern was obstructive in 11, non-obstructive in 3 and normal in 14. DLCO was low in 26 (mild 9, moderate 13, severe 4). Out of 4 pulmonary biopsies (1 transbronchial and 3 surgical) SRIF was found in the surgical ones. Final diagnoses: ILD 19 (Table 2), COPD and/or emphysema 17. In 17 patients SRIF was associated with other smoking related-ILD:9 CPFE, 5 RB-ILD, 2 pulmonary LCH, 1 RA-ILD. 21 patients were evaluated in ILD multidisciplinary meeting Conclusions: 1-Radiologists must consider SRIF on performing HRCT on smokers or ex-smokers. 2-SRIF may coexist with multiple HRCT patterns of smoking-related ILD

As previous studies have shown Interstitial lung diseases(ILD)would be a risk factor for lung cancer(LC)development OBJECTIVES: Describing our population of patients with concomitant ILD and LC as well as knowing their survival MATERIAL AND METHODS: Prospective study started in 2012 comprising 41 patients with ILD and LC revised in ILD consult(25%)or LC consult(75%).The variables included were age,sex,smoking habit,radiological ILD pattern,FVC,DLCO,histology,tumor localization,stage,treatment and time until death RESULTS: The average age was 71.9±8.4;95% were male.70% ex-smokers and 30% smokers.The radiological patterns were:20 UIP,8 possible UIP,8 inconsistent UIP,4 NSIP and 1 LCH.The average FVC was 94±19 and DLCO 50±16.Most tumors(61%)were located in the upper lobes.3 patients were not biopsy-proven,16 squamous cell carcinoma,11 ADC,8 SCLC and 3 NOS carcinoma.20 patients were diagnosed in stages I and II and 21 in stages III and IV.Only 4 patients underwent surgery,5 chemotherapy,5 radiotherapy,16 combined treatment and 11 palliative treatment.There were 23 deaths(average time to death 5.3 months±4.5).No statistically significant differences in mean time to death between different radiological patterns of ILD were shown. CONCLUSIONS: LC represents a major comorbidity in ILD patients,mainly in those with UIP pattern Concomitance of ILD and LC has an adverse impact on survival.There was no difference in mean survival between the different radiological patterns of ILD.