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2. GSTP1 and GSTO1 Variant Alleles Affect Susceptibility to Helicobacter pylori Infection and Severity of Helicobacter pylori -Associated Clinical Manifestations †.

Author

Pantic, Ivana, Lugonja, Sofija, Jerotic, Djurdja, Pljesa-Ercegovac, Marija, Matic, Marija, Bakovic, Nikola, Vojnovic, Marko, Simic, Tatjana, Milovanovic, Tamara, and Savic-Radojevic, Ana

Subjects
GLUTATHIONE transferase, GENETIC variation, HAPLOTYPES, GENETIC polymorphisms, SYMPTOMS
Abstract

Considering the mutual relationship between redox disbalance and inflammation in Helicobacter pylori (HP) infection, we aimed to evaluate whether the polymorphisms in antioxidant glutathione transferases genes (GSTP1 rs1695, GSTP1rs1138272, GSTO1 rs4925 and GSTO2 rs156697) modify susceptibility to HP infection, as well as the severity of HP-associated gastric manifestation development. Therefore, GST gene polymorphisms were determined via the appropriate PCR in 101 HP-positive and 107 HP-negative patients. Our results show that carriers of the GSTP1*G/G variant genotype (rs1695) or at least one GSTP1*T variant allele (rs1138272) were more prone to the development of HP-positive gastritis compared with reference allele carriers (OR = 3.21, 95%CI = 1.15–8.91, p = 0.025 and OR = 2.31, 95%CI = 1.14–4.89, p = 0.021, respectively), which was confirmed by haplotype analysis. HP-positive carriers of the GSTO1*A variant allele showed increased risk of developing gastric atrophy and precancerous gastric lesions compared with the reference one (OR = 2.49, 95%CI:1.04–5.96, p = 0.04 and OR = 2.98, 95%CI = 1.21–7.34, p = 0.018, respectively). HP-positive carriers of the GSTO2*G variant allele were less prone to developing moderate/severe inflammatory infiltration (OR = 0.35, 95%CI = 1.04–5.96, p = 0.04), whereas the GSTP1*T variant allele was significantly associated with active inflammation (OR = 4.09, 95%CI = 1.04–5.96, p = 0.042). In conclusion, antioxidant GST genetic propensity seems to have an important impact on both acute and chronic forms of HP infection. [ABSTRACT FROM AUTHOR]

Published
2025
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5. GPX3 Variant Genotype Affects the Risk of Developing Severe Forms of COVID-19

Author

Markovic, Marko, primary, Ranin, Jovan, additional, Bukumiric, Zoran, additional, Jerotic, Djurdja, additional, Savic-Radojevic, Ana, additional, Pljesa-Ercegovac, Marija, additional, Djukic, Tatjana, additional, Ercegovac, Marko, additional, Asanin, Milika, additional, Milosevic, Ivana, additional, Stevanovic, Goran, additional, Simic, Tatjana, additional, Coric, Vesna, additional, and Matic, Marija, additional

Published
2023
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6. Antioxidant Genetic Variants Modify Echocardiography Indices in Long COVID

Author

Asanin, Milika, primary, Ercegovac, Marko, additional, Krljanac, Gordana, additional, Djukic, Tatjana, additional, Coric, Vesna, additional, Jerotic, Djurdja, additional, Pljesa-Ercegovac, Marija, additional, Matic, Marija, additional, Milosevic, Ivana, additional, Viduljevic, Mihajlo, additional, Stevanovic, Goran, additional, Ranin, Jovan, additional, Simic, Tatjana, additional, Bukumiric, Zoran, additional, and Savic-Radojevic, Ana, additional

Published
2023
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9. Antioxidant Genetic Profile Modifies Probability of Developing Neurological Sequelae in Long-COVID

Author

Ercegovac, Marko, primary, Asanin, Milika, additional, Savic-Radojevic, Ana, additional, Ranin, Jovan, additional, Matic, Marija, additional, Djukic, Tatjana, additional, Coric, Vesna, additional, Jerotic, Djurdja, additional, Todorovic, Nevena, additional, Milosevic, Ivana, additional, Stevanovic, Goran, additional, Simic, Tatjana, additional, Bukumiric, Zoran, additional, and Pljesa-Ercegovac, Marija, additional

Published
2022
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10. SOD2 rs4880 and GPX1 rs1050450 polymorphisms do not confer risk of COVID-19, but influence inflammation or coagulation parameters in Serbian cohort

Author

Jerotic, Djurdja, primary, Ranin, Jovan, additional, Bukumiric, Zoran, additional, Djukic, Tatjana, additional, Coric, Vesna, additional, Savic-Radojevic, Ana, additional, Todorovic, Nevena, additional, Asanin, Milika, additional, Ercegovac, Marko, additional, Milosevic, Ivana, additional, Pljesa-Ercegovac, Marija, additional, Stevanovic, Goran, additional, Matic, Marija, additional, and Simic, Tatjana, additional

Published
2022
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11. GSTO1, GSTO2 and ACE2 Polymorphisms Modify Susceptibility to Developing COVID-19

Author

Djukic, Tatjana, primary, Stevanovic, Goran, additional, Coric, Vesna, additional, Bukumiric, Zoran, additional, Pljesa-Ercegovac, Marija, additional, Matic, Marija, additional, Jerotic, Djurdja, additional, Todorovic, Nevena, additional, Asanin, Milika, additional, Ercegovac, Marko, additional, Ranin, Jovan, additional, Milosevic, Ivana, additional, Savic-Radojevic, Ana, additional, and Simic, Tatjana, additional

Published
2022
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13. GSTP1 and GSTM3 Variant Alleles Affect Susceptibility and Severity of COVID-19

Author

Coric, Vesna, primary, Milosevic, Ivana, additional, Djukic, Tatjana, additional, Bukumiric, Zoran, additional, Savic-Radojevic, Ana, additional, Matic, Marija, additional, Jerotic, Djurdja, additional, Todorovic, Nevena, additional, Asanin, Milika, additional, Ercegovac, Marko, additional, Ranin, Jovan, additional, Stevanovic, Goran, additional, Pljesa-Ercegovac, Marija, additional, and Simic, Tatjana, additional

Published
2021
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14. FKBPL and SIRT-1 Are Downregulated by Diabetes in Pregnancy Impacting on Angiogenesis and Endothelial Function

Author

Alqudah, Abdelrahim, primary, Eastwood, Kelly-Ann, additional, Jerotic, Djurdja, additional, Todd, Naomi, additional, Hoch, Denise, additional, McNally, Ross, additional, Obradovic, Danilo, additional, Dugalic, Stefan, additional, Hunter, Alyson J., additional, Holmes, Valerie A., additional, McCance, David R., additional, Young, Ian S., additional, Watson, Chris J., additional, Robson, Tracy, additional, Desoye, Gernot, additional, Grieve, David J., additional, and McClements, Lana, additional

Published
2021
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15. GSTM1 Modulates Expression of Endothelial Adhesion Molecules in Uremic Milieu

Author

Jerotic, Djurdja, primary, Suvakov, Sonja, additional, Matic, Marija, additional, Alqudah, Abdelrahim, additional, Grieve, David J., additional, Pljesa-Ercegovac, Marija, additional, Savic-Radojevic, Ana, additional, Damjanovic, Tatjana, additional, Dimkovic, Nada, additional, McClements, Lana, additional, and Simic, Tatjana, additional

Published
2021
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16. FKBPL and SIRT-1, key angiogenesis proteins, are downregulated by diabetes in pregnancy

Author

Alqudah, Abdelrahim, primary, Eastwood, Kelly-Ann, additional, Jerotic, Djurdja, additional, Todd, Naomi, additional, Hoch, Denise, additional, McNally, Ross, additional, Obradovic, Danilo, additional, Dugalic, Stefan, additional, Hunter, Alyson J., additional, Holmes, Valerie A., additional, McCance, David R., additional, Young, Ian S., additional, Watson, Chris J, additional, Robson, Tracy, additional, Desoye, Gernot, additional, Grieve, David J, additional, and McClements, Lana, additional

Published
2020
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17. Role of A Novel Angiogenesis FKBPL-CD44 Pathway in Preeclampsia Risk Stratification and Mesenchymal Stem Cell Treatment

Author

Todd, Naomi, primary, McNally, Ross, additional, Alqudah, Abdelrahim, additional, Jerotic, Djurdja, additional, Suvakov, Sonja, additional, Obradovic, Danilo, additional, Hoch, Denise, additional, Hombrebueno, Jose R, additional, Campos, Guillermo Lopez, additional, Watson, Chris J, additional, Gojnic-Dugalic, Miroslava, additional, Simic, Tatjana P, additional, Krasnodembskaya, Anna, additional, Desoye, Gernot, additional, Eastwood, Kelly-Ann, additional, Hunter, Alyson J, additional, Holmes, Valerie A, additional, McCance, David R, additional, Young, Ian S, additional, Grieve, David J, additional, Kenny, Louise C, additional, Garovic, Vesna D, additional, Robson, Tracy, additional, and McClements, Lana, additional

Published
2020
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18. Vitamin E-Bonded Membranes Do Not Influence Markers of Oxidative Stress in Hemodialysis Patients with Homozygous Glutathione Transferase M1 Gene Deletion

Author

Djuric, Petar, primary, Suvakov, Sonja, additional, Simic, Tatjana, additional, Markovic, Dragana, additional, Jerotic, Djurdja, additional, Jankovic, Aleksandar, additional, Bulatovic, Ana, additional, Tosic Dragovic, Jelena, additional, Damjanovic, Tatjana, additional, Marinkovic, Jelena, additional, Naumovic, Radomir, additional, and Dimkovic, Nada, additional

Published
2020
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20. Association of SOD2 (rs4880) and GPX1 (rs1050450) Gene Polymorphisms with Risk of Balkan Endemic Nephropathy and its Related Tumors

Author

Dragicevic, Biljana, primary, Suvakov, Sonja, additional, Jerotic, Djurdja, additional, Reljic, Zorica, additional, Djukanovic, Ljubica, additional, Zelen, Ivanka, additional, Pljesa-Ercegovac, Marija, additional, Savic-Radojevic, Ana, additional, Simic, Tatjana, additional, Dragicevic, Dejan, additional, and Matic, Marija, additional

Published
2019
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21. Association of Nrf2, SOD2 and GPX1 Polymorphisms with Biomarkers of Oxidative Distress and Survival in End-Stage Renal Disease Patients

Author

Jerotic, Djurdja, primary, Matic, Marija, additional, Suvakov, Sonja, additional, Vucicevic, Katarina, additional, Damjanovic, Tatjana, additional, Savic-Radojevic, Ana, additional, Pljesa-Ercegovac, Marija, additional, Coric, Vesna, additional, Stefanovic, Aleksandra, additional, Ivanisevic, Jasmina, additional, Jelic-Ivanovic, Zorana, additional, McClements, Lana, additional, Dimkovic, Nada, additional, and Simic, Tatjana, additional

Published
2019
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22. Markers of Oxidative Stress and Endothelial Dysfunction Predict Haemodialysis Patients Survival

Author

Suvakov, Sonja, primary, Jerotic, Djurdja, additional, Damjanovic, Tatjana, additional, Milic, Natasa, additional, Pekmezovic, Tatjana, additional, Djukic, Tatjana, additional, Jelic-Ivanovic, Zorana, additional, Savic Radojevic, Ana, additional, Pljesa-Ercegovac, Marija, additional, Matic, Marija, additional, McClements, Lana, additional, Dimkovic, Nada, additional, Garovic, Vesna D., additional, Albright, Robert C., additional, and Simic, Tatjana, additional

Published
2019
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23. Role of A Novel Angiogenesis FKBPL-CD44 Pathway in Preeclampsia Risk Stratification and Mesenchymal Stem Cell Treatment.

Author

Todd, Naomi, McNally, Ross, Alqudah, Abdelrahim, Jerotic, Djurdja, Suvakov, Sonja, Obradovic, Danilo, Hoch, Denise, Hombrebueno, Jose R, Campos, Guillermo Lopez, Watson, Chris J, Gojnic-Dugalic, Miroslava, Simic, Tatjana P, Krasnodembskaya, Anna, Desoye, Gernot, Eastwood, Kelly-Ann, Hunter, Alyson J, Holmes, Valerie A, McCance, David R, Young, Ian S, and Grieve, David J

Subjects
MESENCHYMAL stem cells, STEM cell treatment, PREECLAMPSIA, NEOVASCULARIZATION, PREGNANCY complications, CELL physiology, STEM cell transplantation, PREECLAMPSIA diagnosis, RESEARCH, CELL culture, RESEARCH methodology, CELL receptors, CASE-control method, PROGNOSIS, MEDICAL cooperation, EVALUATION research, RISK assessment, CELLULAR signal transduction, COMPARATIVE studies, PATHOLOGIC neovascularization, DRUG therapy, RESEARCH funding, EPITHELIAL cells
Abstract

Context: Preeclampsia is a leading cardiovascular complication in pregnancy lacking effective diagnostic and treatment strategies.Objective: To investigate the diagnostic and therapeutic target potential of the angiogenesis proteins, FK506-binding protein like (FKBPL) and CD44.Design and Intervention: FKBPL and CD44 plasma concentration or placental expression were determined in women pre- or postdiagnosis of preeclampsia. Trophoblast and endothelial cell function was assessed following mesenchymal stem cell (MSC) treatment and in the context of FKBPL signaling.Settings and Participants: Human samples prediagnosis (15 and 20 weeks of gestation; n ≥ 57), or postdiagnosis (n = 18 for plasma; n = 4 for placenta) of preeclampsia were used to determine FKBPL and CD44 levels, compared to healthy controls. Trophoblast or endothelial cells were exposed to low/high oxygen, and treated with MSC-conditioned media (MSC-CM) or a FKBPL overexpression plasmid.Main Outcome Measures: Preeclampsia risk stratification and diagnostic potential of FKBPL and CD44 were investigated. MSC treatment effects and FKBPL-CD44 signaling in trophoblast and endothelial cells were assessed.Results: The CD44/FKBPL ratio was reduced in placenta and plasma following clinical diagnosis of preeclampsia. At 20 weeks of gestation, a high plasma CD44/FKBPL ratio was independently associated with the 2.3-fold increased risk of preeclampsia (odds ratio = 2.3, 95% confidence interval [CI] 1.03-5.23, P = 0.04). In combination with high mean arterial blood pressure (>82.5 mmHg), the risk further increased to 3.9-fold (95% CI 1.30-11.84, P = 0.016). Both hypoxia and MSC-based therapy inhibited FKBPL-CD44 signaling, enhancing cell angiogenesis.Conclusions: The FKBPL-CD44 pathway appears to have a central role in the pathogenesis of preeclampsia, showing promising utilities for early diagnostic and therapeutic purposes. [ABSTRACT FROM AUTHOR]

Published
2021
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