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Your search keyword '"Jeong, Do Hyeon"' showing total 30 results
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4. Development of a biomarker‐based platform for comprehensive skin characterization using minimally invasive skin sampling and quantitative real‐time PCR.

Author

Kim, Seo Hyeong, Kim, Ji Hye, Choi, Yoon Mi, Seo, Su Min, Jang, Eun Young, Lee, Sung Jae, Zhang, Hyun‐Soo, Roh, Yunho, Jung, Yeon Woo, Park, Chang Ook, Jeong, Do Hyeon, and Lee, Kwang Hoon

Subjects
KOREANS, MYELIN proteins, GENE expression, SKIN aging, SKIN care, PEPTIDASE
Abstract

Background: Classifying diverse skin types is crucial for promoting skin health. However, efficiently identifying and analyzing relevant biomarkers from a vast array of available genetic data is challenging. Therefore, this study aimed to develop a precise and efficient platform for analyzing specific skin biomarkers using quantitative real‐time PCR (qRT‐PCR) with the minimal invasive skin sampling method (MISSM). Materials and methods: MISSM was used for RNA extraction from skin samples, followed by qRT‐PCR analysis to quantify the expression of 20 biomarkers associated with skin characteristics (four biomarkers each for five skin characteristics). Noninvasive measurements from 299 Korean participants were utilized to correlate biomarker expression with skin parameters. Statistical analyses were conducted between biomarker expression levels and noninvasive skin measurements to select the relatively best‐performing biomarker for each skin characteristic. Results: Collagen type 1 alpha 1 (COL1A1) and moesin (MSN) were identified as skin aging biomarkers. Krüppel‐like factor 4 (KLF4) and serine peptidase inhibitor Kazal type 5 (SPINK5) were identified as skin dryness biomarkers, whereas melan‐A (MLANA) was selected as a biomarker for understanding pigmentation dynamics. Myelin protein zero like 3 (MPZL3) and high mobility group box 2 (HMGB2) were identified as markers of oily skin and skin sensitivity, respectively. Statistically significant correlations were found between the biomarker expression levels and noninvasive skin characteristic measurements. Conclusion: This study successfully developed a platform for the precise evaluation of individual skin characteristics using MISSM and qRT‐PCR biomarker analysis. By selecting biomarkers that correlate with noninvasive measurements of skin characteristics, we demonstrated the platform's efficacy in assessing diverse skin conditions. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Microneedles: A novel clinical technology for evaluating skin characteristics.

Author

Kim, Seo Hyeong, Kim, Ji Hye, Choi, Yoon Mi, Seo, Su Min, Jang, Eun Young, Lee, Sung Jae, Cho, Suhyun, Jeong, Do Hyeon, and Lee, Kwang Hoon

Subjects
SKIN aging, VITAMIN D receptors, ARTIFICIAL skin, SKIN, AGING prevention, MEDICAL equipment
Abstract

Background: Current methods for evaluating efficacy of cosmetics have limitations because they cannot accurately measure changes in the dermis. Skin sampling using microneedles allows identification of skin‐type biomarkers, monitoring treatment for skin inflammatory diseases, and evaluating efficacy of anti‐aging and anti‐pigmentation products. Materials and methods: Two studies were conducted: First, 20 participants received anti‐aging treatment; second, 20 participants received anti‐pigmentation treatment. Non‐invasive devices measured skin aging (using high‐resolution 3D‐imaging in the anti‐aging study) or pigmentation (using spectrophotometry in the anti‐pigmentation study) at weeks 0 and 4, and adverse skin reactions were monitored. Skin samples were collected with biocompatible microneedle patches. Changes in expression of biomarkers for skin aging and pigmentation were analyzed using qRT‐PCR. Results: No adverse events were reported. In the anti‐aging study, after 4 weeks, skin roughness significantly improved in 17 out of 20 participants. qRT‐PCR showed significantly increased expression of skin‐aging related biomarkers: PINK1 in 16/20 participants, COL1A1 in 17/20 participants, and MSN in 16/20 participants. In the anti‐pigmentation study, after 4 weeks, skin lightness significantly improved in 16/20 participants. qRT‐PCR showed significantly increased expression of skin‐pigmentation‐related biomarkers: SOD1 in 15/20 participants and Vitamin D Receptor (VDR) in 15/20 participants. No significant change in TFAP2A was observed. Conclusion: Skin sampling and mRNA analysis for biomarkers provides a novel, objective, quantitative method for measuring changes in the dermis and evaluating the efficacy of cosmetics. This approach complements existing evaluation methods and has potential application in assessing the effectiveness of medical devices, medications, cosmeceuticals, healthy foods, and beauty devices. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Perfluoroalkylated alternating copolymer possessing solubility in fluorous liquids and imaging capabilities under high energy radiation

Author

Oh, Hyun-Taek, primary, Jung, Seok-Heon, additional, Kim, Kang-Hyun, additional, Moon, Yina, additional, Jeong, Do Hyeon, additional, Ku, Yejin, additional, Lee, Sangsul, additional, Park, Byeong-Gyu, additional, Lee, Jiyoul, additional, Koh, Chawon, additional, Nishi, Tsunehiro, additional, Kim, Hyun-Woo, additional, and Lee, Jin-Kyun, additional

Published
2021
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18. Efficacy of transdermal immunotherapy with biodegradable microneedle patches in a murine asthma model

Author

Park, Kyung Hee, primary, Oh, Eun Yi, additional, Han, Heejae, additional, Kim, Jung Dong, additional, Kim, Sung Jin, additional, Jeong, Kyoung Yong, additional, Kim, Ji Hye, additional, Park, Chang Ook, additional, Kim, Sung‐Ryeol, additional, Lee, Jae‐Hyun, additional, Jeong, Do Hyeon, additional, Yong, Tai‐Soon, additional, Lee, Kwang Hoon, additional, and Park, Jung‐Won, additional

Published
2020
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19. Tranexamic Acid Analysis as Ethoxycarbonyl‐ tert ‐butyldimethylsilyl Derivatives by Gas Chromatography–Tandem Mass Spectrometry

Author

Park, Hyung‐Jin, primary, Lee, Hyeon‐Seong, additional, Seo, Chan, additional, Min, Jeuk, additional, Ji, Moongi, additional, Kim, Youngbae, additional, Choi, Subin, additional, Kim, Doo‐Young, additional, Kim, Jung Dong, additional, Jeong, Do Hyeon, additional, Lee, Wonjae, additional, and Paik, Man‐Jeong, additional

Published
2020
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24. A comparative study of dissolving hyaluronic acid microneedles with trehalose and poly(vinyl pyrrolidone) for efficient peptide drug deliveryElectronic supplementary information (ESI) available. See DOI: 10.1039/c8bm00768c

Author

KimEqual contribution., Hong Kee, Lee, Soo Hyeon, Lee, Boo Yong, Kim, Sung Jin, Sung, Chang Yub, Jang, Na Keum, Kim, Jung Dong, Jeong, Do Hyeon, Ryu, Hyeon Yeol, and Lee, Somin

Abstract

We studied the role of the additives trehalose and poly(vinyl pyrrolidone) in the physical and pharmacokinetic properties of peptide drug incorporated hyaluronic acid microneedles. Poly(vinyl pyrrolidone) increases the mechanical strength of microneedles and ameliorates drug bioavailability in vivo, suggesting that poly(vinyl pyrrolidone) can be a promising additive in the fabrication of peptide drug-encapsulated fully dissolving microneedles.

Published
2018
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