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2. Real-World Eligibility and Cost-Effectiveness Analysis of Empagliflozin for Heart Failure in Korea.

Author

Kim, Eui-Soon, Park, Sun-Kyeong, Youn, Jong-Chan, Lee, Hye, Lee, Hae-Young, Cho, Hyun-Jai, Choi, Jin-Oh, Jeon, Eun-Seok, Lee, Sang, Kim, Min-Seok, Kim, Jae-Joong, Hwang, Kyung-Kuk, Cho, Myeong-Chan, Chae, Shung, Kang, Seok-Min, Park, Jin, Choi, Dong-Ju, Yoo, Byung-Su, Cho, Jae, Kim, Kye, Oh, Byung-Hee, Greenberg, Barry, and Baek, Sang

Subjects
Cost-Effectiveness Analysis, Drug Therapy, Empagliflozin, Heart Failure, SGLT2 Inhibitors, United States, Humans, Heart Failure, Cost-Effectiveness Analysis, Prospective Studies, Stroke Volume, Republic of Korea
Abstract

BACKGROUND: The US Food and Drug Administration (FDA) and European Medicines Agency (EMA) approved empagliflozin for reducing cardiovascular mortality and heart failure (HF) hospitalization in patients with both HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF). However, limited data are available on the generalizability of empagliflozin to clinical practice. Therefore, we evaluated real-world eligibility and potential cost-effectiveness based on a nationwide prospective HF registry. METHODS: A total of 3,108 HFrEF and 2,070 HFpEF patients from the Korean Acute Heart Failure (KorAHF) registry were analyzed. Eligibility was estimated by inclusion and exclusion criteria of EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Reduced Ejection Fraction (EMPEROR-Reduced) and EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Preserved Ejection Fraction (EMPEROR-Preserved) trials and by FDA & EMA label criteria. The cost-utility analysis was done using a Markov model to project the lifetime medical cost and quality-adjusted life year (QALY). RESULTS: Among the KorAHF patients, 91.4% met FDA & EMA label criteria, while 44.7% met the clinical trial criteria. The incremental cost-effectiveness ratio of empagliflozin was calculated at US$6,764 per QALY in the overall population, which is far below a threshold of US$18,182 per QALY. The cost-effectiveness benefit was more evident in patients with HFrEF (US$5,012 per QALY) than HFpEF (US$8,971 per QALY). CONCLUSION: There is a large discrepancy in real-world eligibility for empagliflozin between FDA & EMA labels and clinical trial criteria. Empagliflozin is cost-effective in HF patients regardless of ejection fraction in South Korea health care setting. The efficacy and safety of empagliflozin in real-world HF patients should be further investigated for a broader range of clinical applications. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT01389843.

Published
2024

4. Eligibility and Cost-Utility Analysis of Dapagliflozin in Patients with Heart Failure Across the Whole Spectrum of Ejection Fraction in South Korea

Author

Kim, Eui-Soon, Park, Sun-Kyeong, Cho, Daniel Sung-ho, Youn, Jong-Chan, Lee, Hye Sun, Lee, Hae-Young, Cho, Hyun-Jai, Choi, Jin-Oh, Jeon, Eun-Seok, Lee, Sang Eun, Kim, Min-Seok, Kim, Jae-Joong, Hwang, Kyung-Kuk, Cho, Myeong-Chan, Chae, Shung Chull, Kang, Seok-Min, Park, Jin Joo, Choi, Dong-Ju, Yoo, Byung-Su, Cho, Jae Yeong, Kim, Kye Hun, Oh, Byung-Hee, Greenberg, Barry, and Baek, Sang Hong

Published
2024
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6. Age- and Sex-Related Differences in Patients With Wild-Type Transthyretin Amyloidosis: Insights From THAOS

Author

Emdin, Michele, Hanna, Mazen, Azevedo, Olga, Lino Cirami, Calogero, Gonzalez Costello, Jose, Slosky, David, Moelgaard, Henning, Nativi Nicolau, Jose, Hummel, Scott, Jeon, Eun-Seok, Fine, Nowell, Murali, Srinivas, Miller, Edward, Shah, Sanjiv, Witteles, Ronald, Waddington-Cruz, Marcia, Lenihan, Daniel, Sekijima, Yoshiki, Van Cleemput, Johan, Correia, Edileide de Barros, Cariou, Eve, Quan, Dianna, Freimer, Miriam, Steidley, David, Hüsing-Kabar, Anna, Plante-Bordeneuve, Violaine, Nienhuis, Hans, Wixner, Jonas, Ralph, Jeffrey, Ventura, Hector, Zivkovic, Sasa, Delgado, Diego, Fernandéz Torrón, Roberto, Gottlieb, Stephen, Cotts, William, Tallaj, Jose, Brunkhorst, Robert, Polydefkis, Michael, Mueller, Christopher, Tschoepe, Carsten, Gonzalez Moreno, Juan, Sarswat, Nitasha, Luo, Jin, Tauras, James, Warner, Alberta, Mora-Ayestaran, Nerea, Dispenzieri, Angela, Kristen, Arnt V., Maurer, Mathew S., Diemberger, Igor, Drachman, Brian M., Grogan, Martha, Gupta, Pritam, Glass, Oliver, Amass, Leslie, and Garcia-Pavia, Pablo

Published
2024
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8. Metformin treatment is associated with improved survival in diabetic patients hospitalized with acute heart failure: A prospective observational study using the Korean acute heart failure registry data

Author

Chun, Kyeong-Hyeon, Oh, Jaewon, Lee, Chan Joo, Park, Jin Joo, Lee, Sang Eun, Kim, Min-Seok, Cho, Hyun-Jai, Choi, Jin-Oh, Lee, Hae-Young, Hwang, Kyung-Kuk, Kim, Kye Hun, Yoo, Byung-Su, Choi, Dong-Ju, Baek, Sang Hong, Jeon, Eun-Seok, Kim, Jae-Joong, Cho, Myeong-Chan, Chae, Shung Chull, Oh, Byung-Hee, and Kang, Seok-Min

Published
2024
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16. A randomized, double-blind, multicenter, phase III study on the efficacy and safety of a combination treatment involving fimasartan, amlodipine, rosuvastatin in patients with essential hypertension and dyslipidemia who fail to respond adequately to fimasartan monotherapy

Author

Jeon, Eun-Seok, Lim, Sang Wook, Kim, Seok-Yeon, Yang, Hyoung-Mo, Kim, Moo Hyun, Rhee, Moo-Yong, Han, Seung Hwan, Shin, Jinho, Kim, Kwang-il, Jeong, Jin-Ok, Sung, Ki Chul, Hong, Geu Ru, Kim, Hyung-Seop, Kwon, Kihwan, Kang, Tae-Soo, Lee, Hae-Young, and Han, Su-Eun

Published
2022
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17. Correction: Assessment of clinical effect and treatment quality of immediate-release carvedilol-IR versus SLOW release carvedilol-SR in Heart Failure patients (SLOW-HF): study protocol for a randomized controlled trial

Author

Choi, Dong-Ju, Park, Chan Soon, Park, Jin Joo, Lee, Hae-Young, Kang, Seok-Min, Yoo, Byung-Su, Jeon, Eun-Seok, Hong, Seok Keun, Shin, Joon-Han, Kim, Myung-A, Park, Dae-Gyun, Kim, Eung-Ju, Hong, Soon-Jun, Kim, Seok Yeon, and Kim, Jae-Joong

Published
2022
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19. Temporal Trends of Wild-Type Transthyretin Amyloid Cardiomyopathy in the Transthyretin Amyloidosis Outcomes Survey

Author

Barroso, Fabio Adrian, Van Cleemput, Johan, Fine, Nowell, Schmidt, Hartmut, Gess, Burkhard, Moelgaard, Henning, Planté-Bordeneuve, Violaine, Adams, David, Inamo, Jocelyn, Vita, Giuseppe, Cirami, Calogero Lino, Luigetti, Marco, Emdin, Michele, Sekijima, Yoshiki, Yamashita, Taro, Jeon, Eun-Seok, Gonzalez Duarte Briseno, Maria Alejandra, Nienhuis, Hans, Azevedo, Olga, Campistol Plana, Josep Maria, Moreno, Juan Gonzalez, Costello, Jose Gonzalez, Wixner, Jonas, Parman, Yesim, Shah, Sanjiv, Quan, Dianna, Marburger, Tessa, Polydefkis, Michael, Gottlieb, Stephen, Ralph, Jeffrey, Sarswat, Nitasha, Luo, Jin, Murali, Srinivas, Cotts, William, Drachman, Brian, Steidley, David, Hummel, Scott, Slosky, David, Ventura, Hector, Jacoby, Daniel, Hoffman, James, Tauras, James, Zivkovic, Sasa, Tallaj, Jose, Lenihan, Daniel, Mueller, Christopher, Nativi-Nicolau, Jose, Siu, Alfonso, Dispenzieri, Angela, Maurer, Mathew S., Rapezzi, Claudio, Kristen, Arnt V., Garcia-Pavia, Pablo, LoRusso, Samantha, Waddington-Cruz, Márcia, Lairez, Olivier, Witteles, Ronald, Chapman, Doug, Amass, Leslie, and Grogan, Martha

Published
2021
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20. Sex-Related Risk of Cardiac Involvement in Hereditary Transthyretin Amyloidosis: Insights From THAOS

Author

van Cleemput, Johan, Waddington-Cruz, Marcia, Schmidt, Hartmut, Dillmann, Klaus-Ulrich, Mølgaard, Henning, Moreno, Juan Gonzalez, Costello, Jose Gonzalez, Beamud, Francisco Munoz, Davila, Lucia Galan, Adams, David, Inamo, Jocelyn, Lairez, Olivier, Vita, Giuseppe, Merlini, Giampaolo, Cirami, Calogero Lino, Luigetti, Marco, Emdin, Michele, Sekijima, Yoshiki, Jeon, Eun-Seok, Oh, Jeeyoung, Gonzalez Duarte Briseno, Maria Alejandra, Nienhuis, Hans, Coelho, Teresa, Conceicao, Isabel, Azevedo, Olga, Badelita, Sorina, Press, Rayomand, Parman, Yesim, Shah, Sanjiv, Quan, Dianna, Marburger, Tessa, Polydefkis, Michael, Witteles, Ronald, Gottlieb, Stephen, Sarswat, Nitasha, Drachman, Brian, Steidley, David, Hummel, Scott, Slosky, David, Jacoby, Daniel, Nativi-Nicolau, Jose, Tauras, James, Zivkovic, Sasa, Tallaj, Jose, Lenihan, Daniel, Caponetti, Angelo Giuseppe, Rapezzi, Claudio, Gagliardi, Christian, Milandri, Agnese, Dispenzieri, Angela, Kristen, Arnt V., Wixner, Jonas, Maurer, Mathew S., Garcia-Pavia, Pablo, Tournev, Ivailo, Planté-Bordeneuve, Violaine, Chapman, Douglass, and Amass, Leslie

Published
2021
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21. A Randomized, Double-blind, Active-controlled, Two Parallel-Group, Optional Titration, Multicenter, Phase IIIb Study to Evaluate the Efficacy and Safety of Fimasartan Versus Perindopril Monotherapy With and Without a Diuretic Combination in Elderly Patients With Essential Hypertension

Author

Lee, Hae-Young, Kim, Kwang-il, Ihm, Sang Hyun, Rhee, Moo-Yong, Sohn, Il Suk, Park, Sungha, Jeon, Eun-Seok, Song, Jong-Min, Pyun, Wook Bum, Sung, Ki-Chul, Kim, Moo Hyun, Kim, Sang-Hyun, Kim, Seok-Yeon, Kim, Shin-Jae, Kim, Eung Ju, Shin, Jinho, Lee, Sung Yun, Chun, Kook-Jin, Jeong, Jin-Ok, Chae, Shung Chull, Yoo, Ki Dong, Choi, Young Jin, Park, Yong Hwan, and Kim, Cheol-Ho

Published
2021
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26. Long-term safety and efficacy of patisiran for hereditary transthyretin-mediated amyloidosis with polyneuropathy: 12-month results of an open-label extension study

Author

Vita, Giuseppe, Rizzo, Vincenzo, Russo, Massimo, Mazzeo, Anna, Gentile, Luca, Berk, John L, Brueckner, Caitlin, Lazzari, Victoria, Wiesman, Janice, DeLong, Douglas, Victory, Jennifer, Dalton, James, May, John, Gilmore, Catherine, Attarian, Shahram, Diallo, Saran, Delmont, Emilien, Pouget, Jean, Verschueren, Annie, Grapperon, Aude-Marie, Campana-Salort, Emmanuelle, Conceição, Isabel M, Lopes, Ana, Lamas, Filipa, Neves, Carlos, Castro, Jose, Pereira, Pedro, Castro, Isabel, Franco, Ana, Santos, Miguel Oliveira, de Azevedo Coutinho, Conceição, Falcao de Campos, Catarina, Coelho, Teresa, Hipólito Reis, Antonio, Correia, Nuno, Perez, Javier M, Martins da Silva, Ana, Alves, Cristina, Cardoso, Marcio, Valdrez, Katia, Monte, Julia R, Pessoa, Bernardete, Guimaraes, Nadia, Freitas, Monica, Ramalho, Joana, Ferreira, Natalia, Kuzume, Daisuke, Tard, Celine, Waucquier, Nawal, Rougeaux, Isabelle, Brice, Sylvie, Kasprzyk, Emmanuelle, Elrezzi, Elise, Meguig, Sayah, Hachulla, Eric, Gauvain, Clement, Migaud-Chervy, Maria-Claire, Deplanque, Dominique, Jozefowicz, Elsa, Lebellec, Loic, Adams, David, Balaya-Gouraya, Line, Jehan Lacour, Nathalie, Bournane, Halima, Martin, Nathalie, Elabed, Mongia, Sacko, Niamey, Boubrit, Yasmine, Gaouar, Amina, Rakotondratafika, Fetra, Théaudin-Saliou, Marie, Cauquil-Michon, Cécile, Labeyrie, Celine, Not, Adeline, Al-Salameh, Abdallah, Lecoq, Anne-Lise, Stephant, Maeva, Echaniz-Laguna, Andoni, Becquemont, Laurent, Beaudonnet, Guillemette, Algalarrondo, Vincent, Eliahou, Ludivine, Slama, Michel S, Rousseau, Antoine, Signate, Aissatou, Berthelot, Emeline, Inamo, Jocelyn, Planté-Bordeneuve, Violaine, Vervoitte, Laetitia, Focseneanu, Cecile, Gendre, Thierry, Arrouasse, Raphaele, Ayache, Samar S., Ernande, Laura, Le Corvoisier, Philippe, Salhi, Hayet, Choumert, Ariane, Ehinger, Vincent, Ruiz, Julie, Charlin, Cyril, Megelin, Thomas, Brannagan III, Thomas H, Fayerman, Raisy, Kim, Arreum, Paras, Allan, Gonzalez, Leidy J, Tsang, Steven, Wajnsztajn, Fernanda, Shije, Jeffrey, Ulane, Christina, Kleyman, Inna, Weimer, Louis, Cioroiu, Comana, Lambrianides, Sakis, Abu-Manneh, Rana, Zamba-Papanicolaou, Eleni, Agathangelou, Petros, Leonidou, Eleni, Tada, Satoshi, Fujita, Akemi, Nagai, Masahiro, Ando, Rina, Hosokawa, Yuko, Yamanishi, Yuki, Overcash, J. Scott, Giardino, Elena, Boyer, Leslie, Dang, Lien, Le, An, Nguyen, Tyler, Giang, Lien, Sellers, Peter, Tran, Leyla, Truong, Nghi, Vinas, Maita, Hrkman, Nicole, Miller, Sarah, Nguyen, David, Smith, Ashley, Pu, Helen, Li, Steve, Vuong, Thao, Dioso, Holly, Green, Sinikka, Lee, Kia, Chu, Hanh, Waters, Michael, Coskun, Derya J, Zepeda, Karla A, O'Riordan, William, Obici, Laura, Cortese, Andrea, Lozza, Alessandro, Merlini, Giampaolo, Rosti, Vittorio, Sabatelli, Mario, Bisogni, Giulia, Bernardo, Daniela, Luigetti, Marco, Di Paolantonio, Andrea, Guglielmino, Valeria, Romano, Angela, Nienhuis, Hans, Bulthuis-Kuiper, Janita, Kristen, Arnt V, Gerk, Olga, Ulbricht, Hannah, Taylor, Lenka, Meyle, Eva, Kleinschmidt, Natalia, Meyrath, David, Noe-Schwenn, Simone, Meng, Ulrike, Bauer, Ralf, aus dem Siepen, Fabian, Hein, Selina, Takahashi, Tetsuya, Oshita, Tomohiko, Koujin, Yoko, Neshige, Shuichiro, Nezu, Tomohisa, Segawa, Akiko, Ueno, Hiroki, Morino, Hiroyuki, Campistol, Josep M, Rodas Marin, Lida Maria, Blasco Pelicano, Josep Miquel, Dávila, Lucía Galán, Palacios, Marta, Pytel Cordoba, Vanesa, Guerrero Sola, Antonio, Horga, Alejandro, García Feijoo, Julián, Perez de Isla, Leopoldo, Marques Júnior, Wilson, Moscardini, Mariana, Litcanov, Debora Cristina, Viera Lima, Ana Flavia, Rodrigues, Leonardo, Marques Coutinho, Barbara, Moreira, Carolina Lavigne, Daccach Marques, Vanessa, Munoz Beamud, Francisco, Gragera Martínez, Álvaro, Borrachero, Cristina, Losada López, Inés Asunción, Cisneros Barroso, Eugenia, Rodríguez Rodríguez, Adrián, Sanz, Monica, Rigo Oliver, Elena, González Moreno, Juan, Gamez Martinez, Jose M, Descals, Cristina, Uson, Mercedes, Jose Vega, Francisco, Figuerola, Antoni, Montala, Carles, Waddington-Cruz, Márcia, Dias da Silva, Moises, Gervais de Santa Rosa, Renata, Pinto, Luiz Felipe, Pinto, Marcus Vinicius, Cardoso Berensztejn, Amanda, Barroso, Fabio, Lautre, Andrea, Orellana, Lucas G, González-Duarte Briseño, Maria Alejandra, Cárdenas-Soto, Karla, Jiménez López, Brenda Poled, Pérez-Castañeda, Sandra Lorena, Cantú Brito, Carlos Gerardo, Rivera de la Parra, David, Hernandez Reyes, Jose Pablo, del Mar Saniger Alba, Maria, Criollo Mora, Elia, Parman, Yesim, Rezzan, Kus Jülide, Sahin, Erdi, Serbest, Nail G, Durmus, Hacer, Cakar, Arman, Tugal Tutkun, Nuriye Ilknur, Karamursel, Sacit, Elitok, Ali, Sirin Inan, Nermin G, Altinkurt, Emre, Polydefkis, Michael, Ye, Jing, Allen, Adriane C, Chaudhry, Vinay, Jarrett, Raquel, Bressler, Neil, Burks, Kathleen L, Liu, Qingfeng, Khoshnoodi, Mohammad, Judge, Daniel P, Vista, Geno, Shah, Syed Mahmood, Hamaguchi, Hirotoshi, Oda, Junko, Fukase, Emi, Taniguchi, Ikuko, Oda, Tetsuya, Endo, Hironobu, Shimomura, Masahiro, Katanazaka, Kimitaka, Koto, Shusuke, Nakano, Takahiro, Scheid, Christof, Zueiter, Andreas, Pester, Lars, Walter, Doreen, Özdemir, Betül, Frenzel, Lukas F, Holtick, Udo, Oh, Jeeyoung, Kim, Hee Jin, Shin, Hyun Jin, Choi, Kyomin, Yamashita, Taro, Ueda, Mitsuharu, Masuda, Teruaki, Misumi, Yohei, Ueda, Akihiko, Nakahara, Keiichi, Yorita, Akiko, Tsuruhisa, Seiko, Taniwaki, Takayuki, Harada, Masaya, Moritaka, Taiga, Sakurada, Naonori, Mauricio, Elizabeth A, Baskin, Amber, Dimberg, Elliot, Dispenzieri, Angela, Fonder, Amie, Hobbs, Miriam, Russell, Stephen J, Dyck, Peter, Gonsalves, Wilson, Leung, Nelson, Witzig, Thomas E, Zeldenrust, Steven R, Hwa, Lisa, Kapoor, Prashant, Kumar, Shaji K, Lin, Yi, Lust, John A, Rajkumar, Vincent S, Dingli, David, Gertz, Morie A, Go, Ronald, Hayman, Suzanne R, Dalia, Samir, Carrillo, Esmeralda, Gorevic, Peter, Mason, Garnette, Chao, Chi-Chao, Lee, Ming-Jen, Su, Jen-Jen, Hsieh, Sung-Tsang, Tsai, Li-Kai, Yeh, Shin-Joe, Yang, Chih-Chao, Ajroud-Driss, Senda Ajroud-Driss, Casey, Patricia, Joslin, Benjamin C, Freimer, Miriam, Sankey, Alison, Kenepp, Amanda, Heintzman, Sarah, LoRusso, Samantha, Hokezu, Youichi, Kim, Byoung-Joon, Kim, JuHyeon, Lee, Ga Yeon, Cho, Eun Bin, Jeon, Eun-Seok, Min, Ju-Hong, Seok, Jin Myoung, Lee, Hye Lim, Park, Jae Hong, Sekijima, Yoshiki, Miyazawa, Chinatsu, Kato, Nagaaki, Kishida, Dai, Hineno, Akiyo, Kodaira, Minori, Yoshinaga, Tsuneaki, Miyahara, Teruyoshi, Imai, Akira, Matsumoto, Kazuhiko, Lin, Kon-Ping, Lee, Yi-Chung, Wixner, Jonas, Falk, Malin, Pilebro, Bjorn, Suhr, Ole, Lindqvist, Per, Soderberg, Karin, Pedrosa-Domellöf, Fatima, Anan, Intissar, Nordh, Erik, Tournev, Ivaylo, Zhelyazkova-Glaveeva, Sashka, Cherneva, Zheyna, Sarafov, Staiko, Chamova, Teodora, Cherninkova-Gopina, Sylvia, Schmidt, Hartmut H, Friebel, Frauke, Zibert, Andree, Mihailovic, Natasa, Schubert, Friederike, Vorona, Elena, Lahme, Larissa, Huesing-Kabar, Anna, Schilling, Matthias, Kabar, Iyad, Gillmore, Julian D, Martinez-Naharro, Ana, Chacko, Liza, Cohen, Oliver, Law, Steven, Rezk, Tamer, Lachmann, Helen J, Quan, Dianna, Blume, Brianna, Dixon, Stacy, Low, Soon Chai, Chan, Soo Looi, Lim, He Eng Li, Goh, Khean Jin, Mezei, Michelle M, Kraus, Deborah, Jack, Kristin, Wade, N. Kevin, Lopate, Glenn, Zwijack, Brittany, Florence, Julaine, Sommerville, R. Brian, Stewart, Graeme, Ryder, Julie, Mekhael, Linda, Taylor, Mark, Suan, Daniel, Wells, Karen, Stone, Paula, Itoya, Amenze, Owusu-Sekyere, Mercy, Thai, Desmond, Chahine, Ilonah, Pedrosa, Salve, Do, Thi Hoa (Therese), González-Duarte, Alejandra, Kyriakides, Theodoros, Ajroud-Driss, Senda, Mauricio, Elizabeth, Brannagan, Thomas H, III, Aldinc, Emre, Wang, Jing Jing, White, Matthew T, Vest, John, Berber, Erhan, and Sweetser, Marianne T

Published
2021
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28. SARS-CoV2 mRNA vaccine intravenous administration induces myocarditis in chronic inflammation.

Author

Jeon, Ha-Eun, Lee, Seonghyun, Lee, Jisun, Roh, Gahyun, Park, Hyo-Jung, Lee, Yu-Sun, Kim, Yeon-Jung, Kim, Hong-Ki, Shin, Ji-Hwa, Lee, You-Jeung, Gil, Chae-Ok, Jeon, Eun-Seok, Nam, Jae-Hwan, and Lim, Byung-Kwan

Subjects
CARDIOTOXICITY, INTRAVENOUS therapy, TROPONIN I, COVID-19 pandemic, COVID-19 vaccines
Abstract

The current COVID-19 mRNA vaccines were developed and applied for pandemic-emergent conditions. These vaccines use a small piece of the virus's genetic material (mRNA) to stimulate an immune response against COVID-19. However, their potential effects on individuals with chronic inflammatory conditions and vaccination routes remain questionable. Therefore, we investigated the effects of mRNA vaccines in a mouse model of chronic inflammation, focusing on their cardiac toxicity and immunogenicity dependent on the injection route. mRNA vaccine intravenous administration with or without chronic inflammation exacerbated cardiac pericarditis and myocarditis; immunization induced mild inflammation and inflammatory cytokine IL-1beta and IL-6 production in the heart. Further, IV mRNA vaccination induced cardiac damage in LPS chronic inflammation, particularly serum troponin I (TnI), which dramatically increased. IV vaccine administration may induce more cardiotoxicity in chronic inflammation. These findings highlight the need for further research to understand the underlying mechanisms of mRNA vaccines with chronic inflammatory conditions dependent on injection routes. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Frequency‐Selective, Multi‐Channel, Self‐Powered Artificial Basilar Membrane Sensor with a Spiral Shape and 24 Critical Bands Inspired by the Human Cochlea.

Author

Jeon, Eun‐Seok, Lee, Useung, Yoon, Seongho, Hur, Shin, Choi, Hongsoo, and Han, Chang‐Soo

Subjects
*BASILAR membrane, *ARTIFICIAL membranes, *COCHLEA, *POLYIMIDE films, *PIEZOELECTRIC detectors, *COCHLEA physiology
Abstract

A spiral‐artificial basilar membrane (S‐ABM) sensor is reported that mimics the basilar membrane (BM) of the human cochlea and can detect sound by separating it into 24 sensing channels based on the frequency band. For this, an analytical function is proposed to design the width of the BM so that the frequency bands are linearly located along the length of the BM. To fabricate the S‐ABM sensor, a spiral‐shaped polyimide film is used as a vibrating membrane, with maximum displacement at locations corresponding to specific frequency bands of sound, and attach piezoelectric sensor modules made of poly(vinylidene fluoride‐trifluoroethylene) film on top of the polyimide film to measure the vibration amplitude at each channel location. As the result, the S‐ABM sensor implements a characteristic frequency band of 96‐12,821 Hz and 24‐independent critical bands. Using real‐time signals from discriminate channels, it is demonstrated that the sensor can rapidly identify the operational noises from equipment processes as well as vehicle sounds from environmental noises on the road. The sensor can be used in a variety of applications, including speech recognition, dangerous situation recognition, hearing aids, and cochlear implants, and more. [ABSTRACT FROM AUTHOR]

Published
2024
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37. Risk prediction for 30-day heart failure-specific readmission or death after discharge: Data from the Korean Acute Heart Failure (KorAHF) registry

Author

Lim, Nam-Kyoo, Lee, Sang Eun, Lee, Hae-Young, Cho, Hyun-Jai, Choe, Won-Seok, Kim, Hokon, Choi, Jin Oh, Jeon, Eun-Seok, Kim, Min-Seok, Kim, Jae-Joong, Hwang, Kyung-Kuk, Chae, Shung Chull, Baek, Sang Hong, Kang, Seok-Min, Choi, Dong-Ju, Yoo, Byung-Su, Kim, Kye Hun, Cho, Myeong-Chan, Oh, Byung-Hee, and Park, Hyun-Young

Published
2019
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40. Outcomes After Predischarge Initiation of β-Blocker in Patients Hospitalized for Severe Decompensated Heart Failure Requiring Inotropic Therapy

Author

Cho, Min Soo, Kim, Min-Seok, Lee, Sang Eun, Choi, Hyo-In, Lee, Jung-Bok, Cho, Hyun-Jai, Lee, Hae-Young, Choi, Jin-Oh, Jeon, Eun-Seok, Hwang, Kyung-Kuk, Chae, Shung Chul, Baek, Sang Hong, Kang, Seok-Min, Choi, Dong-Ju, Yoo, Byung-Su, Ahn, Youngkeun, Kim, Kye-Hoon, Park, Hyun-Young, Cho, Myeong-Chan, Oh, Byung-Hee, and Kim, Jae-Joong

Published
2018
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41. Effect of renin-angiotensin system blockade in patients with severe renal insufficiency and heart failure

Author

Jang, Se Yong, Chae, Shung Chull, Bae, Myung Hwan, Lee, Jang Hoon, Yang, Dong Heon, Park, Hun Sik, Cho, Yongkeun, Cho, Hyun-Jai, Lee, Hae-Young, Oh, Byung-Hee, Choi, Jin-Oh, Jeon, Eun-Seok, Kim, Min-Seok, Lee, Sang Eun, Kim, Jae-Joong, Hwang, Kyung-Kuk, Cho, Myeong-Chan, Baek, Sang Hong, Kang, Seok-Min, Choi, Dong-Ju, Yoo, Byung-Su, Ahn, Youngkeun, Kim, Kye Hun, and Park, Hyun-Young

Published
2018
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42. Effects of angiotensin receptor blocker at discharge in patients with heart failure with reduced ejection fraction: Korean Acute Heart Failure (KorAHF) registry

Author

Choi, Ki Hong, Lee, Ga Yeon, Choi, Jin-Oh, Jeon, Eun-Seok, Lee, Hae-Young, Cho, Hyun-Jai, Lee, Sang Eun, Kim, Min-Seok, Kim, Jae-Joong, Hwang, Kyung-Kuk, Chae, Shung Chull, Baek, Sang Hong, Kang, Seok-Min, Choi, Dong-Ju, Yoo, Byung-Su, Kim, Kye Hun, Park, Hyun-Young, Cho, Myeong-Chan, and Oh, Byung-Hee

Published
2018
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43. The Effect of Door-to-Diuretic Time on Clinical Outcomes in Patients With Acute Heart Failure

Author

Park, Jin Joo, Kim, Sun-Hwa, Oh, Il-Young, Choi, Dong-Ju, Park, Hyun-Ah, Cho, Hyun-Jai, Lee, Hae-Young, Cho, Jae-Yeong, Kim, Kye Hun, Son, Jung-Woo, Yoo, Byung-Su, Oh, Jaewon, Kang, Seok-Min, Baek, Sang Hong, Lee, Ga Yeon, Choi, Jin Oh, Jeon, Eun-Seok, Lee, Sang Eun, Kim, Jae-Joong, Lee, Ju-Hee, Cho, Myeong-Chan, Jang, Se Yong, Chae, Shung Chull, and Oh, Byung-Hee

Published
2018
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