57 results on '"Jensen RD"'
Search Results
2. "They forget that I'm a human being"-ward round communication with older patients living with frailty and informal caregivers: a qualitative study.
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Andersen LH, Løfgren B, Skipper M, Krogh K, and Jensen RD
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- Humans, Female, Male, Aged, Aged, 80 and over, Middle Aged, Frailty, Adult, Caregivers psychology, Qualitative Research, Communication, Frail Elderly psychology
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Purpose: Skilful communication prompts quality patient care. Informal caregivers occupy a crucial role when caring for hospitalised older patients living with frailty. However, skilful communication with both patients and informal caregivers during ward rounds has not been studied. Thus, we aimed to explore communication preferences of patients and informal caregivers during ward rounds., Methods: We conducted semi-structured interviews with hospitalized patients and informal caregivers until information redundancy occurred. We used inductive coding of the transcribed interviews followed by a reflexive thematic analysis., Results: The study included 15 patients and 15 informal caregivers. Patients had a median age of 85 years (range 75-100 years) and seven patients were females. Informal caregivers' median age were 45 years (range 38-80 years) and 13 were females. Three themes were generated: (1) building relationships and conveying information, (2) alleviating informal caregiver strain and (3) sharing the decision-making process. Themes highlighted the importance of collaborative and empathetic approaches in healthcare interactions, emphasizing interpersonal communication skills, such as fostering professional relationships. The interviews unveiled informal caregiver burden stemming from disempowerment during hospital discharge process and managing mistrust within the healthcare system. The shared decision-making process should address patients' and informal caregivers' needs and circumstances., Conclusions: Communication preferences of a population of older patients living with frailty and informal caregivers during ward rounds encompass interpersonal communication, demonstrating ample time, and being seen as a human being. Informal caregivers value being included in the decision-making process. Skilful communication includes for doctors to recognize informal caregivers' narratives and burdens., Competing Interests: Declarations. Conflict of interest: The authors report there are no competing interests to declare. Ethical approval: This study was approved by the Institutional Review Board of Aarhus University, Aarhus, Denmark (2023–002). Informed consent: All the interviewees gave their oral and written informed consent to participate in this study., (© 2024. The Author(s).)
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- 2024
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3. Hurricane-induced pollinator shifts in a tightly coadapted plant-hummingbird mutualism.
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Schrøder TSO, Gonçalves F, Vollstädt MGR, Zhang T, Jensen RD, Tarazona-Tubens FL, Kim S, Galetti M, Simmons BI, Kaiser-Bunbury CN, Temeles EJ, and Dalsgaard B
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- Animals, Birds physiology, Adaptation, Physiological, Pollination physiology, Symbiosis physiology, Cyclonic Storms
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- 2024
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4. When I say … active learning.
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Gavarkovs AG, Finan E, Jensen RD, and Brydges R
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- Humans, Problem-Based Learning, Education, Medical
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- 2024
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5. Feel for the game: Simulation as transformative practices.
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Jensen RD
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- Humans, Computer Simulation, Emotions
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- 2024
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6. Supporting self-regulated-learning in colonoscopy training-A comparison cohort trial.
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Jaensch C, Jensen RD, Brydges R, Paltved C, and Madsen AH
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Aim: This study aimed to demonstrate that using a self-regulated learning (SRL) approach can improve colonoscopy performance skills., Background: Colonoscopy is the gold standard for detecting colorectal cancer and removing its precursors: polyps. Acquiring proficiency in colonoscopy is challenging, requiring completion of several hundred procedures. SRL seems to be beneficial to help trainees acquire competencies in regulating their future learning processes and enhance the outcomes of current learning situations. SRL is a learner-centred approach that refers to a trainee's ability to understand and control their learning environment, including cognitions, motivations and emotions. The key abilities include self- and situational awareness, task analysis, and strategic planning. This study is the first to use an SRL approach for workplace-based colonoscopy training., Methods: In this comparison cohort trial, participants used two SRL supports: a self-review of videotaped performance, and an online learning platform with procedural and conceptual knowledge about colonoscopy. In the control cohort, participants performed patient-based colonoscopy as usual in their departments. Improvement was monitored via three video-based ratings (study start, end of the study period, and follow-up) using the Gastrointestinal Endoscopy Competency Assessment Tool (GiECAT). Outcomes were analysed using two-way analysis of variance with repeated measurements., Results: This study recruited 21 participants (12, intervention cohort; nine, control cohort); 58 videos were recorded. The intraclass correlation coefficient was 0.88 (95% CI 0.61-0.98; p < 0.001). The global rating scale (GRS) and checklist (CL) in GiECAT were analysed separately. No statistically significant main effects of cohort (GRS: F(1,16) = 2.84, p = 0.11; CL: F(1,16) = 1.06, p = 0.32), test (GRS: F(2,32) = 2.56, p = 0.09; CL: F(2,32) = 0.76, p = 0.48), or interactions between cohort and test were observed (GRS: F(2,32) = 1.16, p = 0.33; CL: F(2,32) = 1.01, p = 0.37)., Conclusions: SRL in patient-based colonoscopy is feasible; however, no clear effect on performance scores was observed., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Authors.)
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- 2024
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7. No cow on the ice: a tail of word games.
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Jensen RD and Ellaway RH
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- Humans, Ice, Language
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In this editorial, the editors raise the issues of language games in the field of health profession education and examines the implications of translating and communicating meaning from one context to another. This examination raises five issues that scholars in healthcare professions education should consider., (© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)
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- 2024
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8. Correction: Development and validation of a simulation-based assessment tool in colonoscopy.
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Jaensch C, Jensen RD, Paltved C, and Madsen AH
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- 2023
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9. Opportunity to Perform - Should Simulation-Based Surgical Training be Provided on Demand or on Supply?
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Rölfing JD, Sloth SB, Falstie-Jensen T, Mygind-Klavsen B, Elsøe R, and Jensen RD
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Introduction: The aim of the study was to assess the surgical case volume of residents before and after simulation-based training in hip fracture surgery provided on demand versus knee and shoulder arthroscopy provided on supply., Materials and Methods: A retrospective analysis of surgical case volume in hip fracture surgery and arthroscopic shoulder and knee procedures 90 days before and after simulation-based training of either procedure. Sixty-nine orthopedic residents voluntarily participating in either simulation-based training. Hip fracture surgery simulation was provided on supply, ie, whenever 1-2 residents applied for the course, while the arthroscopic simulation course was supplied twice yearly., Results: Thirty-four residents participated in hip fracture simulation on demand and 35 residents participated in arthroscopic simulation on supply. The surgical case volume of hip fracture osteosynthesis increased from median 2.5 (range: 0-21) to median 11.5 (1-17) from 90 days before to the 90 days after the simulation-based training on demand. The median difference was 6.5 procedures (p < 0.0003). On the contrary, the surgical case volume in shoulder and knee arthroscopy was low both before and after the simulation on supply, ie, median 2 (0-22) before and median 1 (0-31) after. The median difference was 0 (p = 0.21)., Conclusions: Simulation on demand was associated with increased opportunities to perform in the clinical environment after the simulation-based training compared with simulation on supply. Simulation-based training should be aligned with the clinical rotation of the residents. Simulation on demand instead of supply on fixed dates may overcome this organizational issue of aligning training with the opportunity to perform., Competing Interests: JDR has received funding and is a consultant for Orthofix Srl. However, each author certifies that there are no funding or commercial associations (consultancies, stock ownership, equity interest, patent/licensing arrangements, etc) that might pose a conflict of interest in connection with the submitted article related to the author or any immediate family members., (© The Author(s) 2023.)
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- 2023
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10. Ward round communication with older patients.
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Andersen LH, Jensen RD, Skipper M, Lietzen LW, Krogh K, and Løfgren B
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- Humans, Communication, Hospitals, Patient Care Team, Frailty, Physicians, Teaching Rounds
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Objectives: Ward round communication is essential to patient care. While communication in general with older patients is well described, little is known about how communication with older patients and their relatives at ward rounds can be optimised. Hence, this scoping review aims to provide an overview of ward round communication with older patients. Furthermore, the review investigates barriers to the optimal communication. Such an overview would provide a point of departure for developing future health care professionals' education in ward round communication training., Method: A scoping review was performed by searching CINAHL, Embase, MEDLINE, and PubMed databases. The search strategy included terms synonymous with "ward rounds" and "older patients." We included studies regarding communication with patients above 65 years during ward rounds. Thematic analysis was applied., Results: Seven of the 2322 identified papers were included in the present review. Thematic analysis revealed three overall themes: Communication strategy, frailty and patient participation, and organisational and age norm challenges. Barriers included frailty-related patient characteristics and imbalance of power between physicians and patients. Papers focused mainly on what the optimal ward round communication should include rather than how it should be performed., Conclusion: Characteristics of frail older patients and organisational barriers challenge effective and safe ward round communication. Little is known about how ward round communication with frail older patients and their relatives can be optimised., (© 2023 The Authors. The Clinical Teacher published by Association for the Study of Medical Education and John Wiley & Sons Ltd.)
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- 2023
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11. Exploring the relationship between simulation-based team training and sick leave among healthcare professionals: a cohort study across multiple hospital sites.
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Schram A, Jensen HI, Gamborg M, Lindhard M, Rölfing J, Kjaergaard-Andersen G, Bie M, and Jensen RD
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- Humans, Cohort Studies, Mental Health, Delivery of Health Care, Sick Leave, Employment
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Objective: Burnout and mental illness are frequent among healthcare professionals, leading to increased sick leave. Simulation-based team training has been shown to improve job satisfaction and mental health among healthcare professionals. This study seeks to investigate the relationship between simulation-based team training and sick leave., Design: Cohort study., Setting and Intervention: Five Danish hospitals., Participants: A total of 15 751 individuals were screened for eligibility. To meet the eligibility criteria, individuals had to be employed in the same group (intervention or control) for the whole study period. A total of 14 872 individuals were eligible for analysis in the study., Intervention: From 2017 to 2019, a simulation-based team training intervention was implemented at two hospital sites. Three hospital sites served as the control group., Outcome Measures: Data on sick leave from 2015 to 2020 covered five hospital sites. Using a difference-in-difference analysis, the rate of sick leave was compared across hospital sites (intervention vs control) and time periods (before vs after intervention)., Results: Significant alterations in sick leave were evident when comparing the intervention and control groups. When comparing groups over time, the increase in sick leave was -0.3% (95% CI -0.6% to -0.0%) lower in the intervention group than in the control group. The difference-in-difference for the complete case analysis showed that this trend remained consistent, with analysis indicating a comparable lower increase in sick leave by -0.7% (95% CI -1.3% to -0.1%) in the intervention group., Conclusion: The increase in sick leave rate was statistically significantly lower in the intervention group, implying that simulation-based team training could serve as a protective factor against sick leave. However, when investigating this simulation intervention over 5 years, other potential factors may have influenced sick leave, so caution is required when interpreting the results., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
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- 2023
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12. Development and validation of a simulation-based assessment tool in colonoscopy.
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Jaensch C, Jensen RD, Paltved C, and Madsen AH
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Background: Colonoscopy is difficult to learn. Virtual reality simulation training is helpful, but how and when novices should progress to patient-based training has yet to be established. To date, there is no assessment tool for credentialing novice endoscopists prior to clinical practice. The aim of this study was to develop such an assessment tool based on metrics provided by the simulator. The metrics used for the assessment tool should be able to discriminate between novices, intermediates, and experts and include essential checklist items for patient safety., Methods: The validation process was conducted based on the Standards for Educational and Psychological Testing. An expert panel decided upon three essential checklist items for patient safety based on Lawshe's method: perforation, hazardous tension to the bowel wall, and cecal intubation. A power calculation was performed. In this study, the Simbionix GI Mentor II simulator was used. Metrics with discriminatory ability were identified with variance analysis and combined to form an aggregate score. Based on this score and the essential items, pass/fail standards were set and reliability was tested., Results: Twenty-four participants (eight novices, eight intermediates, and eight expert endoscopists) performed two simulated colonoscopies. Four metrics with discriminatory ability were identified. The aggregate score ranged from 4.2 to 51.2 points. Novices had a mean score of 10.00 (SD 5.13), intermediates 24.63 (SD 7.91), and experts 30.72 (SD 11.98). The difference in score between novices and the other two groups was statistically significant (p<0.01). Although expert endoscopists had a higher score, the difference was not statistically significant (p=0.40). Reliability was good (Cronbach's alpha=0.86). A pass/fail score was defined at 17.1 points with correct completion of three essential checklist items, resulting in three experts and three intermediates failing and one novice passing the assessment., Conclusion: We established a valid and reliable assessment tool with a pass/fail standard on the simulator. We suggest using the assessment after simulation-based training before commencing work-based learning., (© 2023. Society in Europe for Simulation Applied to Medicine (SESAM) and BioMed Central Ltd.)
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- 2023
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13. Technical, Non-Technical, or Both? A Scoping Review of Skills in Simulation-Based Surgical Training.
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Rosendal AA, Sloth SB, Rölfing JD, Bie M, and Jensen RD
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- Clinical Competence, Learning, Simulation Training methods
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Objective: Technical and non-technical skills are traditionally investigated separately in simulation-based surgical training (SBST). Recent literature has indicated an interrelation of these skills, but a clear relationship is yet to be established. This scoping review aimed to identify published literature on the use of both technical and non-technical learning objectives in SBST and investigate how the entities are related. Additionally, this scoping study reviewed the literature with the aim of mapping how publications on technical and non-technical skills within SBST have changed over time., Design: We conducted a scoping review using the 5 step framework by Arksey and O'Malley and reported our results according to the PRISMA guidelines for scoping reviews. Four databases, PubMed, Web of Science, Embase and Cochrane Library, were systematically searched for empirical studies on SBST. Studies within surgical training addressing both technical and non-technical learning objectives and presenting primary data were included for further analysis., Results: Our scoping review identified 3144 articles on SBST published between 1981 and 2021. During our analysis, an emphasis on technical skills training in published literature was identified. However, recent years have seen an immense increase of publications within either technical or non-technical skills. A similar trend is seen in publications addressing both technical and non-technical. In total, 106 publications addressed both technical and non-technical learning objectives and were included for further analysis. Only 45 of the included articles addressed the relationship between technical and non-technical skills. These articles mainly focused on the effect of non-technical skills on technical skills., Conclusions: Though literature on the relationship between technical and non-technical skills remains scarce, the included studies on technical skills and non-technical skills such as mental training suggest such a relationship exists. This implies that the separation of the skill sets is not necessarily beneficial for the outcome of SBST. A shift towards seeing technical and non-technical skills as intertwined may enhance learning outcomes from SBST., (Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)
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- 2023
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14. Exploring training needs of newly graduated medical doctors to inform the undergraduate simulation-based curriculum: a national Delphi consensus study.
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Breindahl N, Khan F, Skipper M, Nielsen AB, Friis ML, Paltved C, Jensen RD, Kurtzhals JAL, Konge L, and Nayahangan LJ
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- Humans, Delphi Technique, Curriculum, Needs Assessment, Clinical Competence, Simulation Training methods, Education, Medical
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Purpose: Mastering technical procedures is a key component in succeeding as a newly graduated medical doctor and is of critical importance to ensure patient safety. The efficacy of simulation-based education has been demonstrated but medical schools have different requirements for undergraduate curricula. We aimed to identify and prioritize the technical procedures needed by newly graduated medical doctors., Methods: We conducted a national needs assessment survey using the Delphi technique to gather consensus from key opinion leaders in the field. In the first round, a brainstorm was conducted to identify all potential technical procedures. In the second round, respondents rated the need for simulation-based training of each procedure using the Copenhagen Academy for Medical Education and Simulation Needs Assessment Formula (CAMES-NAF). The third round was a final elimination and prioritization of the procedures., Results: In total, 107 experts from 21 specialties answered the first round: 123 unique technical procedures were suggested. Response rates were 58% and 64% in the second and the third round, respectively. In the third round, 104 procedures were eliminated based on the consensus criterion, and the remaining 19 procedures were included and prioritized. The top five procedures were: (i) insert peripheral intravenous catheter, (ii) put on personal protection equipment, (iii) perform basic airway maneuvers, (iv) perform basic life support, and (v) perform radial artery puncture., Conclusion: Based on the Delphi process a final list of 19 technical procedures reached expert consensus to be included in the undergraduate curriculum for simulation-based education., (© The Author(s) 2023. Published by Oxford University Press on behalf of Postgraduate Medical Journal. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
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- 2023
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15. Ticket to perform: an explorative study of trainees' engagement in and transfer of surgical training.
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Sloth SB, Jensen RD, Seyer-Hansen M, De Win G, and Christensen MK
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- Female, Humans, Pregnancy, Clinical Competence, Computer Simulation, Education, Medical, Graduate methods, Operating Rooms, General Surgery education, Obstetric Surgical Procedures education, Urologic Surgical Procedures education, Gynecologic Surgical Procedures education, Internship and Residency, Laparoscopy education
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Background: Research suggests that simulation-based surgical skills training translates into improved operating room performance. Previous studies have predominantly focused on training methods and design and subsequent assessable performances and outcomes in the operating room, which only covers some aspects of training engagement and transfer of training. The purpose of this qualitative study was to contribute to the existing body of literature by exploring characteristics of first-year trainees' engagement in and perceptions of transfer of surgical skills training., Methods: We conducted an explorative study based on individual interviews with first-year trainees in General Surgery, Urology, and Gynaecology and Obstetrics who participated in a laparoscopic skills training program. Informants were interviewed during and two months after the training program. A thematic cross-case analysis was conducted using systematic text condensation., Results: We interviewed 12 informants, which produced 24 transcripts for analysis. We identified four main themes: (1) sportification of training, (2) modes of orientation, (3) transferrable skills, and (4) transfer opportunities. Informants described their surgical training using sports analogies of competition, timing, and step-by-step approaches. Visual orientations, kinaesthetic experiences, and elicited dialogues characterised training processes and engagement. These characteristics were identified in both the simulated and the clinical environment. Experiences of specific skills transfer included ambidexterity, coordination, instrument handling, and visuospatial ability. General transfer experiences were salient in informants' altered training approaches. Informants considered the simulation-based training an entry ticket to perform in the operating room and mentioned supervisor-trainee relationships and opportunities in the workplace as critical conditions of transfer., Conclusions: Our findings elucidate characteristics of surgical training engagement that can be interpreted as self-regulated learning processes that transcend surgical training environments. Despite appreciating the immediate skills improvements resulting from training, trainees' narratives reflected a struggle to transfer their training to the clinical setting. Tensions existed between perceptions of transferable skills and experiences of transfer within the clinical work environments. These results resonate with research emphasising the importance of the work environment in the transfer process. Our findings provide insights that may inform the development of training programs that support self-regulated learning and transfer of training from the simulated to the clinical environment., (© 2023. The Author(s).)
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- 2023
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16. Establishing Construct Validity of a Novel Simulator for Guide Wire Navigation in Antegrade Femoral Intramedullary Nailing.
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Rölfing JD, Salling LB, Long SA, Vogt B, Anderson DD, Thomas GW, and Jensen RD
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- Humans, Analysis of Variance, Bone Screws, Curriculum, Fracture Fixation, Intramedullary, Hip Fractures
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Background: Antegrade femoral intramedullary nailing (IMN) is a common orthopedic procedure that residents are exposed to early in their training. A key component to this procedure is placing the initial guide wire with fluoroscopic guidance. A simulator was developed to train residents on this key skill, building off an existing simulation platform originally developed for wire navigation during a compression hip screw placement. The objective of this study was to assess the construct validity of the IMN simulator., Methods: Thirty orthopedic surgeons participated in the study: 12 had participated in fewer than 10 hip fracture or IMN related procedures and were categorized as novices; 18 were faculty, categorized as experts. Both cohorts were instructed on the goal of the task, placing a guide wire for an IM nail, and the ideal wire position reference that their wire placement would be graded against. Participants completed 2 assessments with the simulator. Performance was graded on the distance from the ideal starting point, distance from the ideal end point, wire trajectory, duration, fluoroscopy image count, and other elements of surgical decision making. A two-way ANOVA analysis was used to analyze the data looking at experience level and trial number., Results: The expert cohort performed significantly better than the novice cohort on all metrics but one (overuse of fluoroscopy). The expert cohort had a more accurate starting point and completed the task while using fewer images and less overall time., Conclusion: This initial study shows that the IMN application of a wire navigation simulator demonstrates good construct validity. With such a large cohort of expert participants, we can be confident that this study captures the performance of active surgeons today. Implementing a training curriculum on this simulator has the potential to increase the performance of the novice level residents prior to their operating on a vulnerable patient. Level of Evidence: III ., (Copyright © The Iowa Orthopaedic Journal 2023.)
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- 2023
17. Using simulation-based training during hospital relocation: a controlled intervention study.
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Schram AL, Lindhard MS, Bie M, Gamborg ML, Toxvig N, Skov G, and Jensen RD
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Background: During hospital relocations, it is important to support healthcare professionals becoming familiar with new settings. Simulation-based training seems promising and in situ simulation has been suggested as a beneficial educational tool to prepare healthcare professionals for relocation. This study aimed to investigate the impact of a simulation-based training intervention on health professionals´ readiness to work in their new environment, as well as investigate sick leave before and after relocation., Methods: The study was a controlled intervention study implemented at a university hospital in Denmark. Simulation was used to prepare employees for workflows prior to relocation. Before relocation, 1199 healthcare professionals participated in the in situ simulation-based training program. Questionnaires on readiness to perform were distributed to participants at pre-, post-, and follow-up (6 months) measurement. In addition, data on participants' sick leave was gathered from a business intelligence portal. To compare dependent and independent groups, paired and unpaired t tests were performed on mean score of readiness to perform and sick leave., Results: Compared to the control group, healthcare professionals participating in the intervention felt significantly more ready to work in a new hospital environment. As a measure of psychological wellbeing, register data indicated no difference in sick leave, when comparing intervention and control groups before and after participating in the in situ simulation-based training program., Conclusions: Healthcare professionals felt significantly more ready to work in a new environment, after participating in the in situ simulation-based training program, indicating that the intervention supported healthcare professionals during relocations. This may mitigate feelings of uncertainty; however, further research is needed to explore such effects., Trial Registration: The study was approved by The Regional Ethics Committee (no. 1-16-02-222-22)., (© 2022. The Author(s).)
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- 2022
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18. Identifying technical skills and clinical procedures for simulation-based training in emergency medicine: A nationwide needs assessment.
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Husted A, Rölfing JD, Ingeman ML, Paltved C, Ludwig M, Konge L, Nayahangan L, and Jensen RD
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- Humans, Needs Assessment, Simulation Training methods, Emergency Medicine education
- Abstract
Competing Interests: Declaration of Competing Interest None.
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- 2022
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19. Re-examining the integration of routine and adaptive expertise: there is no such thing as routine from a motor control perspective.
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Jensen RD, Brydges R, and Grierson L
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- Humans, Clinical Competence, Learning, Curriculum
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The study of adaptive expertise in health professions education has focused almost exclusively on cognitive skills, largely ignoring the processes of adaptation in the performance of precision technical skills. We present a focused review of literature to argue that repetitive practice is much less repetitive than often perceived. Our main thesis is that all skilled movement reflects components of adaptive expertise. Through an overview of perspectives from the field of motor control and learning, we emphasize the interplay between the inherent noisiness of the human motor architecture and the stability of motor skill performances. Ultimately, we challenge the very idea of routine. Our goal is threefold: to reconcile common misconceptions about the rote nature of routine precision skill performance, to offer educators principles to enhance adaptive expertise as an outcome of precision skill training, and to expand the conversation between 'routine' and 'adaptive' forms of expertise in health professions education., (© 2022. Springer Nature B.V.)
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- 2022
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20. Balancing closure and discovery: adaptive expertise in the workplace.
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Gamborg ML, Jensen RD, Musaeus P, and Mylopoulos M
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- Humans, Workplace, Health Personnel, Anthropology, Cultural, Learning, Physicians
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Residents must develop knowledge, skills, and attitudes to handle a rapidly developing clinical environment. To address this need, adaptive expertise has been suggested as an important framework for health professions education. However, research has yet to explore the relationship between workplace learning and adaptive expertise. This study sought to investigate how clinical supervision might support the development of adaptive expertise. The present study used a focused ethnography in two emergency departments. We observed 75 supervising situations with the 27 residents resulting in 116 pages of field notes. The majority of supervision was provided by senior physicians, but also included other healthcare professionals. We found that supervision could serve two purposes: closure and discovery. Supervision aimed at discovery included practices that reflected instructional approaches said to promote adaptive expertise, such as productive struggle. Supervision aimed at closure-included practices with instructional approaches deemed important for efficient and safe patient care, such as verifying information. Our results suggest that supervision is a shared practice and responsibility. We argue that setting and aligning expectations before engaging in supervision is important. Furthermore, results demonstrated that supervision was a dynamic process, shifting between both orientations, and that supervision aimed at discovery could be an an appropriate mode of supervision, even in the most demanding clinical situations., (© 2022. The Author(s), under exclusive licence to Springer Nature B.V.)
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- 2022
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21. Remote training in laparoscopy: a randomized trial comparing home-based self-regulated training to centralized instructor-regulated training.
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Sloth SB, Jensen RD, Seyer-Hansen M, Christensen MK, and De Win G
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- Clinical Competence, Curriculum, Humans, Internship and Residency, Laparoscopy education, Simulation Training methods
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Background: Simulation-based surgical training (SBST) is key to securing future surgical expertise. Proficiency-based training (PBT) in laparoscopy has shown promising results on skills transfer. However, time constraints and limited possibilities for distributed training constitute barriers to effective PBT. Home-based training may provide a solution to these barriers and may be a feasible alternative to centralized training in times of assembly constraints., Methods: We randomly assigned first-year trainees in abdominal surgery, gynecology, and urology to either centralized instructor-regulated training (CIRT) or home-based self-regulated training (HSRT) in laparoscopy. All participants trained on portable box trainers providing feedback on metrics and possibility for video reviewing. Training in both groups was structured as PBT with graded proficiency exercises adopted from the Fundamentals of Laparoscopic Surgery (FLS). The HSRT group trained at home guided by online learning materials, while the CIRT group attended two training sessions in the simulation center with feedback from experienced instructors. Performance tests consisted of hand-eye and bimanual coordination, suture and knot-tying, and FLS exercises. We analyzed passing rates, training time and distribution, and test performances., Results: Passing rates were 87% and 96% in the CIRT and HSRT group, respectively. HSRT facilitated distributed training and resulted in greater variation in training times. Task times for hand-eye and bimanual coordination were significantly reduced between pretest and posttest in both groups. Trainees maintained their posttest performances at the 6-month retention test. Our analyses revealed no significant inter-group differences in performances at pretest, posttest, or retention test. Performance improvements in the two groups followed similar patterns., Conclusion: CIRT and HSRT in laparoscopy result in comparable performance improvements. HSRT in laparoscopy is a feasible and effective alternative to CIRT when offered inside a supportive instructional design. Further research is needed to clarify trainees' preferences and explore facilitators and barriers to HSRT., (© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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- 2022
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22. The use of very low-calorie diets in subjects with obesity complicated with nonalcoholic fatty liver disease: A scoping review.
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Herrington GJ, Peterson JJ, Cheng L, Allington BM, Jensen RD, Healy HS, and Correia MLG
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This scoping review synthesizes the existing research on the use of very low-calorie diets (VLCDs) in subjects with nonalcoholic fatty liver disease (NAFLD) and end-stage liver disease (ESLD). 19 studies were included, of which 5 were clinical trials, 11 were cohort studies, 1 was a case-control study, and 2 were case series totaling 968 subjects. About 17 studies were focused on patients with NAFLD while the two case series described in patients with ESLD on the transplant list or post-liver transplant. Six studies included subjects managed with VLCDs prior bariatric surgery. Most studies were short term and demonstrated acute improvement of diverse liver biomarkers including liver function tests, indices of hepatosteatosis and reduction in liver size. Adherence rates in these studies were between 69% and 93%. Eight studies did not report any adverse events and four subjects were reported to have discontinued VLCD due to adverse effects in two different studies. Aggregated adverse events were mild. Treatments based on VLCD in subjects with NAFLD seem to be safe and tolerable but can result in mild adverse effects. The findings of this scoping review suggest that the use of VLCD in patients with obesity complicated with NAFLD and potentially in ESLD appear to be effective to induce weight loss and to acutely reduce hepatosteatosis., Competing Interests: Marcelo Correia is a consultant to Novo Nordisk Inc. and receives research grants from Stead Family, Eli Lilly & Co., Novo Nordisk Inc., and Novartis. However, these conflicts of interest are unrelated with the topic of this scoping review. The other authors have no conflicts of interest to disclose., (© 2022 The Authors. Obesity Science & Practice published by World Obesity and The Obesity Society and John Wiley & Sons Ltd.)
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- 2022
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23. Healthcare professionals' experience of using in situ simulation training in preparation for the COVID-19 pandemic: a qualitative focus group study from a Danish hospital.
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Juelsgaard J, Løfgren B, Toxvig N, Eriksen GV, Ebdrup L, and Jensen RD
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- Delivery of Health Care, Denmark, Focus Groups, Hospitals, Humans, Pandemics, SARS-CoV-2, COVID-19, Simulation Training
- Abstract
Objectives: The COVID-19 pandemic forced hospital organisation and healthcare professionals to prepare for large quantities of patients in isolation rooms. In situ simulation may seem promising in order to manage the organisational changes that the pandemic require. This study aims to investigate in situ simulations influence on healthcare professional's self-perceived preparedness to face the pandemic., Design: A qualitative focus group study., Setting: We conducted full scale in situ simulations over a 3-week period in April 2020, including 277 healthcare professionals, at a Danish University Hospital. Subsequently, six semistructured focus group interviews, including 22 participants from the simulations, were conducted in May 2020., Participants: 22 healthcare professionals participated in the focus group interviews., Methods: The simulations consisted of a briefing, two scenarios focusing on acute respiratory insufficiency and correct use of personal protective equipment (PPE), and a debriefing. We conducted six focus group interviews using comparable semistructured interview guides focusing on the organisational restructuring of the departments and outcomes of the needs-driven simulation-based programme. We used thematic analysis to identify main themes., Results: The informants perceived that the simulations resulted in positive experiences for the healthcare professionals and perceived the organisational changes as effective. They highlighted that simulation enhanced teamwork, demystified the COVID-19 disease, and improved skills, in correct use of PPE and acute treatment of COVID-19 patients. Data revealed that a predefined simulation task force including both experienced simulators and medical experts for facilitation of in situ simulation would be beneficial., Conclusion: In situ simulation may be useful to enhance learning on organisation and individual level during a pandemic. This educational activity could serve an important role in facilitating hospital preparation and education of large numbers of healthcare professionals during a healthcare crisis. Introduction of a simulation task force is suggested to handle coordination and rapid enrolment across the hospital., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2022
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24. Identifying technical skills and clinical procedures in surgery for a simulation-based curriculum: a national general needs assessment.
- Author
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Jensen RD, Paltved C, Jaensch C, Durup J, Beier-Holgersen R, Konge L, Nayahangan L, and Madsen AH
- Subjects
- Clinical Competence, Computer Simulation, Curriculum, Delphi Technique, Humans, Needs Assessment, General Surgery, Internship and Residency, Simulation Training methods
- Abstract
Background: The efficacy of simulation-based training in surgical education is well known. However, the development of training programs should start with problem identification and a general needs assessment to ensure that the content is aligned with current surgical trainee needs. The objective of the present study is to identify the technical skills and clinical procedures that should be included in a simulation-based curriculum in general surgery., Methods: A national, three-round Delphi process was conducted to achieve consensus on which technical skills and clinical procedures should be included in a simulation-based curriculum in general surgery. In total, 87 key opinion leaders were identified and invited to the study., Results: Round 1 of the Delphi process had a response rate of 64% (56/87) and a total of 245 suggestions. Based on these suggestions, a consolidated list of 51 technical skills or clinical procedures was made. The response rate in Delphi round 2 was 62% (54/87) resulting in a pre-prioritized order of procedures for round 3. The response rate in Delphi round 3 was 65% (35/54). The final list included 13 technical skills and clinical procedures. Training was predominantly requested within general open surgical skills, laparoscopic skills, and endoscopic skills, and a few specific procedures such as appendectomy and cholecystectomy were included in the final prioritized list., Conclusion: Based on the Delphi process 13 technical skills and clinical procedures were included in the final prioritized list, which can serve as a point of departure when developing simulation-based training in surgery., (© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.)
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- 2022
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25. HipSim - hip fracture surgery simulation utilizing the Learning Curve-Cumulative Summation test (LC-CUSUM).
- Author
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Rölfing JD, Jensen RD, and Paltved C
- Subjects
- Adult, Bone Screws, Clinical Competence, Denmark, Female, Humans, Learning Curve, Male, Orthopedic Procedures education, Orthopedic Procedures instrumentation, Orthopedic Procedures methods, Virtual Reality, Computer Simulation, Educational Measurement methods, Hip Fractures surgery, Internship and Residency methods, Orthopedics education, Orthopedics standards, Simulation Training methods
- Abstract
Background and purpose - Virtual reality simulation of hip fracture surgery is available for orthopedic residents nationwide in Denmark. Summative assessment of learning applying the learning curve cumulative summation test (LC-CUSUM) has not been utilized in orthopedic simulation training. The strength of the LC-CUSUM is that it assumes incompetency and signals competency based on solid statistics. We investigated the LC-CUSUM characteristics of novices stepwise mastering the simulated dynamic hip screw (DHS) procedure. Material and methods - 32 1st-year orthopedic residents participated in HipSim and its 3 subsequent LC-CUSUM evaluations: placing a Kirschner wire, placing a Kirschner wire in different patients, and performing the entire DHS procedure in different patients. The career status of the participants, i.e., still working in orthopedics or in another specialty was recorded ≥ 2 years after participation and associated with the simulation performance (passed/failed). Results - 13/14 participants passing HipSim according to LC-CUSUM were still working in orthopedics, while 9/18 participants failing HipSim had quit orthopedics at ≥ 2 years follow-up. The simulator-generated feedback did not statistically significantly differ between the groups. Interpretation - LC-CUSUM and its summative pass/fail assessment of each simulation was feasible in this formative simulation program. Clinical educators can be reassured that participants passing HipSim are likely to continue to 2nd-5th year of residency, while failing HipSim should raise concerns and trigger career counselling and clinical supervision. The motivational aspect of LC-CUSUM pass/fail assessment when designing formative simulation training warrants further research.
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- 2020
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26. The Benefits of Tying Yourself in Knots: Unraveling the Learning Mechanisms of Guided Discovery Learning in an Open Surgical Skills Course.
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Aagesen AH, Jensen RD, Cheung JJH, Christensen JB, Konge L, Brydges R, Thinggaard E, and Kulasegaram KM
- Subjects
- Adult, Cohort Studies, Female, Humans, Male, Clinical Competence, Education, Medical, Graduate methods, General Surgery education, Learning
- Abstract
Purpose: Teaching technical skills through the use of guided discovery learning (GDL) is an ongoing topic of research. In this approach, learners practice and struggle before receiving formal instruction. This has shown promise in other domains of learning, yet in the realm of procedural skills, clarity is still needed. This study seeks to address these gaps by investigating efficacy and mechanisms relating to application for a GDL approach in teaching basic surgical skills., Method: In 2018, young surgical trainees (N = 16) undertook a 6-week open surgical course applying the principles of GDL, each lesson beginning with a discovery phase before subsequent instruction and practice. A concurrent triangulation mixed-methods approach was used with direct observation and collection of semistructured interviews using a framework designed from productive failure literature. At the end of the course, all participants took a conceptual knowledge test and a performance-based skills test. Performance on the skills test was rated using global ratings and checklists., Results: The GDL cohort outperformed the historical cohort on the written exam (F [1,65] = 4.96, P = .029, d = .62), as well as on the summative suturing test (F [1,65] = 6.23, P = .015, d = .68). Furthermore, 3 main themes that highlight the mechanisms and mediators of efficient GDL were: (1) building conceptual knowledge, (2) motivating self-regulated learning, and (3) the type of skill and psychological safety., Conclusions: GDL can be an efficient approach to teaching procedural skills. Implications for future research and curricular design are discussed.
- Published
- 2020
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27. Preparing an orthopedic department for COVID-19.
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Jensen RD, Bie M, Gundsø AP, Schmid JM, Juelsgaard J, Gamborg ML, Mainz H, and Rölfing JD
- Subjects
- Denmark epidemiology, Health Care Surveys, Humans, Infection Control methods, Medical Staff, Hospital organization & administration, SARS-CoV-2, Staff Development methods, Staff Development trends, COVID-19 epidemiology, COVID-19 prevention & control, Delivery of Health Care organization & administration, Delivery of Health Care trends, Infection Control organization & administration, Organizational Innovation, Orthopedics trends, Trauma Centers organization & administration, Trauma Centers trends
- Abstract
Background and purpose - The COVID-19 pandemic has disrupted healthcare services around the world. We (1) describe the organizational changes at a level 1 trauma center, (2) investigate how orthopedic healthcare professionals perceived the immense amount of information and educational activities, and (3) make recommendations on how an organization can prepare for disruptive situations such as the COVID-19 pandemic in the future. Methods - We conducted a retrospective survey on the organizational restructuring of the orthopedic department and the learning outcomes of a needs-driven educational program. The educational activities were evaluated by a non-validated, 7-item questionnaire. Results - The hospital established 5 COVID-19 clusters, which were planned to be activated in sequential order. The orthopedic ward comprised cluster 4, where orthopedic nursing staff were teamed up with internal medicine physicians, while the orthopedic team were redistributed to manage minor and major injuries in the emergency department (ED). The mean learning outcome of the educational activities was high-very high, i.e., 5.4 (SD 0.7; 7-point Likert scale). Consequently, the staff felt more confident to protect themselves and to treat COVID-19 patients. Interpretation - Using core clinical competencies of the staff, i.e., redistribution of the orthopedic team to the ED, while ED physicians could use their competencies treating COVID-19 patients, may be applicable in other centers. In-situ simulation is an efficient tool to enhance non-technical and technical skills and to facilitate organizational learning in regard to complying with unforeseen changes.
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- 2020
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28. Identifying and prioritising technical procedures for simulation-based curriculum in paediatrics: a Delphi-based general needs assessment.
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Thim S, Nayahangan LJ, Paltved C, Jensen RD, Konge L, Hertel NT, and Balslev T
- Abstract
Objectives: To identify and prioritise technical procedures that should be integrated in a curriculum of simulation-based procedural training in paediatrics using the Delphi method., Study Design: National general needs assessment using a Delphi process was completed among 93 key opinion leaders in paediatrics in Denmark. Delphi round 1 identified technical procedures. Round 2 explored frequency of procedures, number of paediatricians performing the procedures, risks and/or discomfort for patients and feasibility for simulation-based training. Round 3 included final elimination and reprioritisation., Results: Response rates in the Delphi rounds were 73%, 71% and 72%. We identified 37 procedures in Delphi round 1, preprioritised in round 2, resulting in a final list of 19 procedures in round 3. Strong correlation between the prioritisation from the second and third Delphi rounds was identified, Spearman's r of 0.94 (p<0.0001). Top five on the final list were acute neonatal airway management, acute non-neonatal airway management, non-neonatal peripheral intravenous and intraosseous access, neonatal vascular access and advanced heart lung resuscitation., Conclusion: We identified and prioritised 19 technical procedures in paediatrics that are suitable for simulation and may be used as a guide for the development of simulation-based curriculum in paediatrics., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2020
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29. Final Word: The Health Technology Community Steps Up to Combat COVID-19.
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Jensen RD
- Subjects
- Betacoronavirus, COVID-19, Humans, SARS-CoV-2, Biomedical Technology, Coronavirus Infections, Pandemics, Pneumonia, Viral
- Published
- 2020
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30. How to play the game of medical education: Sociocultural analyses of educational difficulties among medical residents.
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Christensen MK, Sørensen JK, Jensen RD, Brøndt SG, Norberg K, O'Neill LD, Mortensen LS, and Charles P
- Abstract
This article was migrated. The article was marked as recommended. Medical residents in difficulty struggle to comply with educational requirements. They pose a liability to patient safety and they have problems to adapt to the professional role of a doctor. Consequently, being a resident in difficulty may cause identity crisis and have the potential to disrupt the resident's professional identity as a doctor. Only few studies explore the tipping point between becoming a resident in difficulty or not, and these studies rarely reflect the surrounding sociocultural aspects of the residents' difficulties such as organisational culture in the workplace. This article explores how medical residency training culture influence on residents' risk of ending in difficulty. Our study was based on six focus-group interviews with residents (n=28) and in-depth interviews with residents in difficulty (n=10). The interpretation of data employed sociologist Pierre Bourdieu's theoretical framework around dispositions. Across the data, we identified four themes: Conflicting games in the field of medical education, altruism, organisational hierarchy, and coping with stress. We found a (mis)match between legitimate rules in the field of medicine and the residents' dispositions to appreciate those rules. These results can inform clinical supervisors and consultants in their decisions for supporting residents in difficulty and increasing educational achievement among struggling residents., (Copyright: © 2020 Christensen MK et al.)
- Published
- 2020
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31. Being a surgeon or doing surgery? A qualitative study of learning in the operating room.
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Jensen RD, Seyer-Hansen M, Cristancho SM, and Christensen MK
- Subjects
- Anthropology, Cultural, Female, Humans, Male, Qualitative Research, Students, Medical, Teaching, Learning, Operating Rooms, Surgeons
- Abstract
Context: A key concern for surgical educators is to prepare students to perform in the operating room while ensuring patient safety. Recent years have seen a renewed discussion of medical education through practice theoretical and sociomaterial lenses. These lenses are introduced to understand and prepare the learner to perform in the given context. This paper takes its point of departure from practice theory by introducing a lens through which to understand learning environments in surgery., Methods: Using a multi-site ethnographic and practice-based design, this study investigates how aspiring surgical students are stirred into surgical practices and learn to engage as surgeons. During 70 hours of observations of medical students' participation in the operating room, we analysed how the phenomenon of surgical learning can be perceived as instances of transformation in and among social practices., Results: By applying an analytical perspective, this article highlights the use of practice theory in surgical education, which can help to establish a firmer understanding of the learning environment and thereby help educators to improve curricula and prepare students more effectively to enter surgical training., Conclusions: The use of a practice theory adds the perspective that the education of surgeons needs to take the sayings, doings and relatings that constitute a surgical practice into account when preparing students to perform in their future workplace. In this way, surgical training can be perceived as a process of being stirred into practice. This means that one learns by participating in the practice of providing high-quality care, where the aim is to teach students to be surgeons instead of teaching them to perform surgery., (© 2018 John Wiley & Sons Ltd and The Association for the Study of Medical Education.)
- Published
- 2018
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32. How Surgeons Conceptualize Talent: A Qualitative Study Using Sport Science as a Lens.
- Author
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Jensen RD, Christensen MK, LaDonna KA, Seyer-Hansen M, and Cristancho S
- Subjects
- Adult, Canada, Competency-Based Education, Denmark, Female, Grounded Theory, Humans, Interviews as Topic, Male, Qualitative Research, Sports, Aptitude, Clinical Competence, Education, Medical, Graduate organization & administration, Internship and Residency organization & administration, Specialties, Surgical education
- Abstract
Objectives: Debates prevail regarding the definition of surgical talent, and how individuals with the potential to become talented surgeons can be identified and developed. However, over the past 30 years, talent has been studied extensively in other domains. The objectives of this study is to explore notions of talent in surgery and sport in order to investigate if the field of surgical education can benefit from expanding its view on talented performances. Therefore, this study aims to use the sport literature as a lens when exploring how surgeons conceptualize and define talent., Design: Semi-structured interviews were conducted with a sample of 11 consultant surgeons from multiple specialties. We used constructivist grounded theory principles to explore talent in surgery. Ongoing data analysis refined the theoretical framework and iteratively informed data collection. Themes were identified iteratively using constant comparison., Setting: The setting included 8 separate hospitals across Canada and Denmark., Participants: A total of 11 consultant surgeons from 6 different surgical subspecialties (urology, orthopedic surgery, colorectal surgery, general surgery, vascular surgery, head & neck surgery) were included., Results: We identified three key elements for conceptualizing surgical talent: (1) Individual skills makes the surgical prospect "good", (2) a mixture of skills gives the surgical prospect the potential to become talented, and (3) becoming talented may rely on the fit between person and environment., Conclusion: We embarked on a study aimed at understanding talent in surgery. Talent is a difficult construct to agree on. Whether in medicine or sports, debates about talent will continue to persist, as we all perceive talent differently. While we heard different opinions, three key ideas summarize our participants' discussions regarding surgical talent. These findings resonate with the holistic ecological approach from sport science and hence highlight the limits of a reductionist approach while favoring the individual-environment system as the minimal ontology for describing talented performances., (Copyright © 2017 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.)
- Published
- 2017
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33. A Roundtable Discussion: Thawing Out Healthcare Technology's 'Special Snowflake' Cybersecurity Challenges.
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Jensen RD, Copeland S, Domas S, Hampton R, Hoyme K, Jump M, Rekik I, Schwartz S, and Vasserman E
- Subjects
- Humans, Biomedical Technology, Computer Security
- Published
- 2017
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34. The Internet of Dangerous Things: A Complex Dialogue Worth Advancing.
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Jensen RD
- Published
- 2017
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35. Residents in difficulty--just slower learners? A case-control study.
- Author
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O'Neill LD, Norberg K, Thomsen M, Jensen RD, Brøndt SG, Charles P, Mortensen LS, and Christensen MK
- Subjects
- Achievement, Case-Control Studies, Denmark, Educational Measurement, Humans, Time Factors, Clinical Competence, Internship and Residency, Learning Curve
- Abstract
Background: Recent meta-analyses have found small-moderate positive associations between general performance in medical school and postgraduate medical education. In addition, a couple of studies have found an association between poor performance in medical school and disciplinary action against practicing doctors. The aim of this study was to examine if a sample of Danish residents in difficulty tended to struggle already in medical school, and to determine whether administratively observable performance indicators in medical school could predict difficulties in residency., Methods: The study design was a cumulative incidence matched case-control study. The source population was all active specialist trainees, who were medical school graduates from Aarhus University, in 2010 to June 2013 in two Danish regions. Cases were doctors who decelerated, transferred, or dropped out of residency. Cases and controls were matched for graduation year. Medical school exam failures, grades, completion time, and academic dispensations as predictors of case status were examined with conditional logistic regression., Results: In total 89 cases and 343 controls were identified. The total number of medical school re-examinations and the time it took to complete medical school were significant individual predictors of subsequent difficulties (deceleration, transferral or dropout) in residency whereas average medical school grades were not., Conclusions: Residents in difficulty eventually reached similar competence levels as controls during medical school; however, they needed more exam attempts and longer time to complete their studies, and so seemed to be slower learners. A change from "fixed-length variable-outcome programmes" to "fixed-outcome variable-length programmes" has been proposed as a way of dealing with the fact that not all learners reach the same level of competence for all activities at exactly the same time. This study seems to support the logic of such an approach to these residents in difficulty.
- Published
- 2014
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36. [Dream Team--a pre-graduate surgical talent development project].
- Author
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Jensen RD, Christensen MK, and Seyer-Hansen M
- Subjects
- Aptitude, Clinical Competence, Education, Medical, Focus Groups, Humans, Observation, Program Evaluation, General Surgery education, Program Development
- Abstract
In 2009 surgeons from Aarhus University Hospital founded an extracurricular talent development project based on a skill-acquisition training programme for medical students at Aarhus University. The training program, named Dream Team, provides medical students with the opportunity to pursue a career in surgery. This paper presents and discusses the organizational and pedagogical framework of the concept Dream Team, as well as the results from two inquiries: a survey and an exploratory observational study. The inquiries were conducted in summer 2013.
- Published
- 2014
37. Differences between opioids: pharmacological, experimental, clinical and economical perspectives.
- Author
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Drewes AM, Jensen RD, Nielsen LM, Droney J, Christrup LL, Arendt-Nielsen L, Riley J, and Dahan A
- Subjects
- Analgesics, Opioid economics, Analgesics, Opioid pharmacokinetics, Analgesics, Opioid pharmacology, Animals, Cost of Illness, Drug Costs, Humans, Pain drug therapy, Analgesics, Opioid therapeutic use
- Abstract
Clinical studies comparing the response and side effects of various opioids have not been able to show robust differences between drugs. Hence, recommendations of the regulatory authorities have been driven by costs with a general tendency in many countries to restrict physician's use of opioids to morphine. Although this approach is recognized as cost-effective in most cases there is solid evidence that, on an individual patient basis, opioids are not all equal. Therefore it is important to have an armamentarium of strong analgesics in clinical practice to ensure a personalized approach in patients who do not respond to standard treatment. In this review we highlight differences between opioids in human studies from a pharmacological, experimental, clinical and health economics point of view. We provide evidence that individuals respond differently to opioids, and that general differences between classes of opioids exist. We recommend that this recognition is used to individualize treatment in difficult cases allowing physicians to have a wide range of treatment options. In the end this will reduce pain and side effects, leading to improved quality of life for the patient and reduce the exploding pain related costs., (© 2012 The Authors. British Journal of Clinical Pharmacology © 2012 The British Pharmacological Society.)
- Published
- 2013
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38. You are not alone.
- Author
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Jensen RD
- Subjects
- Humans, United States, Podiatry, Societies organization & administration
- Published
- 2010
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39. Tacrolimus toxicity in rhesus monkey: model for clinical side effects.
- Author
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Kindt MV, Kemp R, Allen HL, Jensen RD, and Patrick DH
- Subjects
- Animals, Hemolytic-Uremic Syndrome pathology, Insulin analysis, Islets of Langerhans drug effects, Islets of Langerhans pathology, Kidney pathology, Macaca mulatta, Pancreas pathology, Tremor chemically induced, Hemolytic-Uremic Syndrome chemically induced, Immunosuppressive Agents therapeutic use, Kidney drug effects, Pancreas drug effects, Tacrolimus toxicity
- Published
- 1999
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40. Extent and persistence of streptozotocin-induced DNA damage and cell proliferation in rat kidney as determined by in vivo alkaline elution and BrdUrd labeling assays.
- Author
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Kraynak AR, Storer RD, Jensen RD, Kloss MW, Soper KA, Clair JH, DeLuca JG, Nichols WW, and Eydelloth RS
- Subjects
- Animals, Cell Division drug effects, Cephaloridine pharmacology, DNA isolation & purification, DNA metabolism, DNA Repair, Kidney cytology, Kidney metabolism, Male, Rats, Rats, Sprague-Dawley, Time Factors, Anti-Bacterial Agents toxicity, Bromodeoxyuridine metabolism, DNA Damage, Kidney drug effects, Streptozocin toxicity
- Abstract
The extent of DNA damage and cellular proliferation induced in rat kidneys by single doses of the diabetogenic alkylating agent streptozotocin (STZ) and the time course of repair of that damage were evaluated using an in vivo alkaline elution assay for DNA strand breaks and a bromodeoxyuridine (BrdUrd) labeling assay for cell replication. Male Sprague-Dawley rats were given iv injections of 0.25 to 60 mg/kg STZ and kidneys were harvested 3 hr later for alkaline elution. A dose of 2.5 mg/kg STZ was the lowest dose to induce detectable DNA strand breaks and extensive damage was produced by the commonly used diabetogenic dose of 60 mg/kg. To characterize the repair of the drug-induced DNA damage, kidneys were harvested from a 60 mg/kg group of animals 3 hr to 27 days after dosing. BrdUrd-labeled kidney sections were also evaluated to assess any cellular proliferative response associated with STZ administration. Significant DNA damage was detected up to 14 days after dosing with return to near background levels by 20 days. Similarly, treatment with 60 mg/kg STZ was associated with increases in BrdUrd labeling indices 4 and 9 days after treatment with resolution by 27 days. These results indicate that the cellular and molecular repair responses to a single diabetogenic dose of STZ are prolonged, requiring up to 3 weeks to complete. Thus, to avoid potential additive or synergistic effects on STZ-induced nephrotoxicity and/or genotoxicity, a delay in the start of experimental therapies in this model (other than insulin) should be considered.
- Published
- 1995
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41. Nocardiosis in liver transplantation: variation in presentation, diagnosis and therapy.
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Forbes GM, Harvey FA, Philpott-Howard JN, O'Grady JG, Jensen RD, Sahathevan M, Casewell MW, and Williams R
- Subjects
- Adult, Drug Resistance, Microbial, Female, Humans, Male, Middle Aged, Nocardia Infections drug therapy, Nocardia Infections etiology, Nocardia asteroides isolation & purification, Liver Transplantation, Nocardia Infections diagnosis, Sulfadiazine therapeutic use, Trimethoprim, Sulfamethoxazole Drug Combination therapeutic use
- Abstract
Nocardiosis arose in seven of 191 liver transplant patients (3.7%) over a period of 3.5 years. Four patients had only pulmonary lesions while three had disseminated disease. Nocardia asteroides was isolated from three patients following bronchoscopy, percutaneous aspirate of a pulmonary lesion in one patients, and from the skin from the aspirates in three patients. Delay in diagnosis in two cases was due to negative microscopy; in one, the diagnosis was made only after repeated bronchoscopy. Of the seven patients, three (43%) died. In two of these, nocardiosis was considered to have directly contributed to death. Co-existent bacterial and viral infections were present in all patients who died. In vitro susceptibility of the organism to co-trimoxazole was variable and did not necessarily reflect clinical efficacy. In one patient, a good clinical response was achieved with co-trimoxazole despite apparently reduced in vitro susceptibility.
- Published
- 1990
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42. Marked anterior displacement of the trachea and larynx from an esophageal obturator airway (EOA).
- Author
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Low RB, Jensen RD, and Cavanaugh KJ
- Subjects
- Aged, Emergency Medical Services, Equipment Failure, Heart Arrest therapy, Humans, Male, Airway Obstruction etiology, Esophagus, Intubation adverse effects
- Abstract
A 67-year-old man suffering cardiopulmonary arrest had an apparently uneventful placement of an esophageal obturator airway (EOA) by a well-trained ambulance crew. Subsequent clinical evaluation showed ventilation to be marginal. Attempts to insert an endotracheal tube were unsuccessful because the larynx could not be visualized. A subsequent postmortem examination showed that the EOA tube was kinked and bent back on itself so that the distal (balloon) end lay underneath the larynx, displacing it anteriorly.
- Published
- 1982
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43. Chronic toxicity/carcinogenesis study of temazepam in mice and rats.
- Author
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Robison RL, Van Ryzin RJ, Stoll RE, Jensen RD, and Bagdon RE
- Subjects
- Animals, Body Weight drug effects, Diet, Eating drug effects, Female, Liver Neoplasms chemically induced, Male, Mice, Neoplasms, Experimental chemically induced, Organ Size drug effects, Rats, Rats, Inbred Strains, Sex Factors, Species Specificity, Time Factors, Anti-Anxiety Agents toxicity, Carcinogens, Temazepam toxicity
- Abstract
The benzodiazepine temazepam was given to Charles River CD rats for 2 years in the diet at dosages of 10, 40, and 160 mg/kg day. An 18-month study was performed in Charles River CD-1 mice via dietary admixture at dosages of 10, 80, and 160 mg/kg/day. Mean body weights were significantly decreased for high dose rats of both sexes from Treatment Week 39 until termination. All drug treated male groups had a higher rate of mortality when compared to the male control groups, primarily due to deaths occurring between 19 to 24 months. Compound-related hepatic lipidosis accompanied by an increase in liver weights was observed at the high dose level in the 6- and 12-month and terminal sacrifices, as well as the middle dose level at the 12-month interim sacrifice. No evidence was found of compound induced carcinogenicity at any time period. Mortality for male mice was significantly higher in the two higher dose groups; this resulted from bite wounds associated with a drug-related increase in fighting behavior. An isolated finding of borderline statistical significance (p = 0.0556) was noted for hepatocellular adenomas in high dose female mice (4/100) at the 18-month terminal sacrifice. This incidence is well within the reported historical control range (0-14%). Minimal hepatoproliferative (hyperplastic nodules) and vascular effects (telangiectasis) were seen in the high dose male and female mice at the 18-month terminal sacrifice. Thus, these results were similar to those previously reported for oxazepam although meaningful effects on neoplasia did not occur with temazepam. Unlike in man, temazepam is primarily metabolized to oxazepam in the mouse and thus these results are not adverse with regard to human safety evaluation.
- Published
- 1984
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44. Varied manifestations of a familial lymphoproliferative disorder.
- Author
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Fraumeni JF, Wertelecki W, Blattner WA, Jensen RD, and Leventhal BG
- Subjects
- Adenocarcinoma complications, Adult, Female, Humans, Leukemia, Lymphoid genetics, Lung Neoplasms complications, Lymphoma genetics, Lymphoma pathology, Male, Pedigree, Waldenstrom Macroglobulinemia complications, Waldenstrom Macroglobulinemia genetics, Lymphatic Diseases genetics
- Abstract
In a sibship of nine adults, four died of lymphocytic or histiocytic lymphomas, and one of Waldenström's macroglobulinemia (immunoglobulin M [IgM], kappa type) complicated by adenocarcinoma of the lung. In the next generation, one member died of Hodgkin's disease; four of nine healthy persons had impaired lymphocyte transformation in vitro in response to phytohemagglutinin-P (PHA-P), and three of these had polyclonal elevations in IgM levels. Subsequent to these observations, adenocarcinoma of the lung developed in one woman with immune defects, and lymphocytic leukemia developed in her 3 year old grandson. The findings in this family point to a genetically regulated defect of immunity expressed as diverse lymphoproliferative disorders, including polyclonal and monoclonal IgM gammopathies. The occurrence of pulmonary adenocarcinoma in two members suggests genetic and immunologic determinants in these instances.
- Published
- 1975
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45. Preclinical toxicological studies of carbidopa and combinations of carbidopa and levodopa.
- Author
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Zwickey RE, Peck HM, Bagdon WJ, Bokelman DL, Brown WR, Hite M, Jensen RD, Mattis PA, Mendlowski B, and Porter CC
- Subjects
- Animals, Carbidopa administration & dosage, Dogs, Drug Interactions, Female, Lethal Dose 50, Levodopa administration & dosage, Macaca mulatta, Male, Mice, Rabbits, Rats, Carbidopa toxicity, Levodopa toxicity
- Published
- 1974
- Full Text
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46. Spontaneous tumors in control F344 and charles river-CD rats and Charles River CD-1 and B6C3HF1 mice.
- Author
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Sher SP, Jensen RD, and Bokelman DL
- Subjects
- Animals, Female, Male, Mice, Inbred Strains, Rats, Inbred F344, Species Specificity, Mice, Neoplasms veterinary, Rats, Rodent Diseases epidemiology
- Abstract
The incidence of spontaneous neoplasms in outbred, inbred and F1 hybrid strains was compared using the Charles River-CD rat and mouse, the F344 rat, and B6C3HF1 mouse. These strains are commonly used in carcinogenic studies. Each strain has a consistent pattern of tumor occurrence; testicular, pituitary and lymphoreticular neoplasms are common in F344 rats, mammary and pituitary neoplasms are common in Charles River-CD rats, liver neoplasms are uncommon in CD-1 mice, while hepatic tumors are frequent in male B6C3HF1 mice. There is considerable variation in tumor incidence in individual studies regardless of strain and there appeared to be greater variation in incidence between laboratories using the same strain than in the different laboratories using unlike strains. Therefore, the choice between these strains may be fortuitous or recommended by governmental agencies. Regardless of the strain selected, it is vital to develop sufficient historical tumor data on the strain used at the particular test laboratory.
- Published
- 1982
- Full Text
- View/download PDF
47. Evidence of hepatitis A infection in immature rhesus monkeys.
- Author
-
Lankas GR and Jensen RD
- Subjects
- Animals, Female, Hepatitis A diagnosis, Hepatitis A enzymology, Hepatitis A pathology, Hepatitis A Antibodies, Hepatitis Antibodies analysis, Hepatovirus immunology, Male, Monkey Diseases enzymology, Monkey Diseases pathology, Alanine Transaminase blood, Aspartate Aminotransferases blood, Hepatitis A veterinary, Macaca, Macaca mulatta, Monkey Diseases diagnosis
- Abstract
Forty immature (less than 2 years old) rhesus monkeys (Macaca mulatta) with marked increases in aspartate and alanine aminotransferase activities were examined. Serological and histopathological evaluations were done to determine if affected animals were infected with hepatitis A virus. Although no clinical signs of illness were noted in any of the monkeys, an excellent correlation was found between the increased serum aminotransferase values and seropositivity with the acute phase (IgM) HAVAB-M antibody. Histopathological evaluations of livers of selected animals revealed hepatic lesions consistent with those in chimpanzees and marmosets infected with hepatitis A virus: generalized activation of sinusoidal lining cells, focal hepatocellular necrosis with occasional acidophilic bodies, and cuffs of mononuclear cells in the portal areas. Although no animals were seropositive for HAVAB upon receipt from the breeding colony, a total of ten of 18 animals for which serological data were available had seroconverted to HAVAB positivity during the 4-month observation period. These results are consistent with hepatitis A infection in immature rhesus monkeys and indicate the potential significance of serological testing in animals in which hepatic function is being evaluated.
- Published
- 1987
- Full Text
- View/download PDF
48. Familial arrhenoblastoma and thyroid adenoma.
- Author
-
Jensen RD, Norris HJ, and Fraumeni JF Jr
- Subjects
- Adenoma complications, Adenoma pathology, Adolescent, Adult, Child, Child, Preschool, Female, Humans, Ovarian Neoplasms complications, Ovarian Neoplasms pathology, Ovary pathology, Sertoli-Leydig Cell Tumor complications, Sertoli-Leydig Cell Tumor pathology, Thyroid Gland pathology, Thyroid Neoplasms complications, Thyroid Neoplasms pathology, Adenoma genetics, Neoplasms, Multiple Primary genetics, Ovarian Neoplasms genetics, Sertoli-Leydig Cell Tumor genetics, Thyroid Neoplasms genetics
- Published
- 1974
- Full Text
- View/download PDF
49. Effect of temperature on water transport through plants.
- Author
-
Jensen RD and Taylor SA
- Published
- 1961
- Full Text
- View/download PDF
50. Relative frequency of ovarian neoplasms in children and adolescents.
- Author
-
Norris HJ and Jensen RD
- Subjects
- Adenocarcinoma epidemiology, Adenocarcinoma, Mucinous epidemiology, Adolescent, Adult, Age Factors, Child, Child, Preschool, Cystadenocarcinoma epidemiology, Dysgerminoma epidemiology, Female, Granulosa Cell Tumor epidemiology, Humans, Infant, Lymphangioma epidemiology, Lymphoma epidemiology, Ovarian Neoplasms classification, Sertoli-Leydig Cell Tumor epidemiology, Teratoma epidemiology, Ovarian Neoplasms epidemiology
- Published
- 1972
- Full Text
- View/download PDF
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