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1. DAHEAN: A Danish nationwide study ensuring quality assurance through real-world data for suspected hereditary anemia patients

Author

Glenthøj, Andreas, Rasmussen, Andreas Ørslev, Bendtsen, Selma Kofoed, Hasle, Henrik, Hoffmann, Marianne, Rieneck, Klaus, Dziegiel, Morten Hanefeld, Sjö, Lene Dissing, Frederiksen, Henrik, Hansen, Dennis Lund, Fassi, Daniel El, Rathe, Mathias, Jensen, Peter-Diedrich Matthias, Winther-Larsen, Anne, Nielsen, Christian, Olsen, Marianne, Toft, Nina, Lorenzen, Mads Okkels Birk, Jensen, Lise Heilmann, Gudbrandsdottir, Sif, Helby, Jens, Rossing, Maria, van Wijk, Richard, and Petersen, Jesper

Published
2024
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2. DAHEAN: A Danish nationwide study ensuring quality assurance through real-world data for suspected hereditary anemia patients

Author

CDL Poli WKZ, CDL Cluster Speciële Diagnostiek, Child Health, Circulatory Health, Glenthøj, Andreas, Rasmussen, Andreas Ørslev, Bendtsen, Selma Kofoed, Hasle, Henrik, Hoffmann, Marianne, Rieneck, Klaus, Dziegiel, Morten Hanefeld, Sjö, Lene Dissing, Frederiksen, Henrik, Hansen, Dennis Lund, Fassi, Daniel El, Rathe, Mathias, Jensen, Peter Diedrich Matthias, Winther-Larsen, Anne, Nielsen, Christian, Olsen, Marianne, Toft, Nina, Lorenzen, Mads Okkels Birk, Jensen, Lise Heilmann, Gudbrandsdottir, Sif, Helby, Jens, Rossing, Maria, van Wijk, Richard, Petersen, Jesper, CDL Poli WKZ, CDL Cluster Speciële Diagnostiek, Child Health, Circulatory Health, Glenthøj, Andreas, Rasmussen, Andreas Ørslev, Bendtsen, Selma Kofoed, Hasle, Henrik, Hoffmann, Marianne, Rieneck, Klaus, Dziegiel, Morten Hanefeld, Sjö, Lene Dissing, Frederiksen, Henrik, Hansen, Dennis Lund, Fassi, Daniel El, Rathe, Mathias, Jensen, Peter Diedrich Matthias, Winther-Larsen, Anne, Nielsen, Christian, Olsen, Marianne, Toft, Nina, Lorenzen, Mads Okkels Birk, Jensen, Lise Heilmann, Gudbrandsdottir, Sif, Helby, Jens, Rossing, Maria, van Wijk, Richard, and Petersen, Jesper

Published
2024

3. PREVALENCE OF SARS-COV-2-ANTIBODIES IN DANISH CHILDREN AND ADULTS

Author

Rytter, Maren J. H., Nygaard, Ulrikka, Mandic, Ida Nikoline, Glenthøj, Jonathan Peter, Schmidt, Lisbeth Samsø, Cortes, Dina, Smith, Birgitte, Zaharov, Tatjana, Søndergaard, Mia Johanna, Lawaetz, Marie Cecilie, Saekmose, Susanne, Jensen, Lise Heilmann, Schmiegelow, Kjeld, and Kristensen, Kim

Published
2021
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4. Recidiverende meningokoksygdom hos kvinde med mutation i C8B-genet

Author

Andersen, Ulrik Ørsø, Bay, Jakob Thaning, Jensen, Lise Heilmann, Andersen, Ulrik Ørsø, Bay, Jakob Thaning, and Jensen, Lise Heilmann

Abstract

This is a case report of recurrent meningococcal infection in a young woman. She had no positive microbiological findings but was serologically diagnosed with the meningococcal antibody test. Investigation of the complement system showed no function of the terminal pathway. Further genetical analysis revealed a pathogen mutation in the C8B gene in the patient and her sister. They were both immunised with meningococcal vaccines. Complement deficiencies are rare but potentially fatal. Workup for complement deficiency is important for correct acute and prophylactic treatment.

Published
2023

6. Systematic review of the prevalence of onychomycosis in children

Author

Vestergaard-Jensen, Sif, Mansouri, Abdullah, Jensen, Lise Heilmann, Jemec, Gregor B. E., Saunte, Ditte Marie L., Vestergaard-Jensen, Sif, Mansouri, Abdullah, Jensen, Lise Heilmann, Jemec, Gregor B. E., and Saunte, Ditte Marie L.

Abstract

Onychomycosis is one of the most common nail diseases in adults but is described as infrequent in children. Data are, however, scattered and diverse. Studies have nevertheless suggested that the prevalence of onychomycosis is increasing in children lately and the aim of this review was therefore to examine this problem. Two authors individually searched PubMed, Embase, and Cochrane Library for articles on epidemiology and prevalence of onychomycosis in children. The literature search was conducted in accordance per PRISMA guidelines. In total 1042 articles were identified of which 23 were eligible for inclusion. One of the articles presented two studies and a total of 24 studies were therefore included. Seventeen studies presented data of the prevalence of onychomycosis in children in the general population and seven studies among children visiting a dermatological and pediatric department or clinic. The prevalence ranged from 0% to 7.66% with an overall discrete increase of 0.66% during the period 1972 to 2014 in population studies (not statistically significant). This review supports a trend towards an increased prevalence of onychomycosis in children, albeit based on a paucity of studies. The data suggests an increasing prevalence of onychomycosis with age, and co-infection with tinea pedis (reported in 25% of the studies). The most common pathogen reported was Trichophyton rubrum and onychomycosis was more prevalent in toenails compared to fingernails. The general characteristics of onychomycosis in children are thus similar to those described in adults.

Published
2022

7. The Worldwide Antibiotic Resistance and Prescribing in European Children (ARPEC) point prevalence survey: developing hospital-quality indicators of antibiotic prescribing for children

Author

Versporten, Ann, Bielicki, Julia, Drapier, Nico, Sharland, Mike, Goossens, Herman, Calle, Graciela Maria, Garrahan, Juan P., Clark, Julia, Cooper, Celia, Blyth, Christopher C., Francis, Joshua Reginald, Alsalman, Jameela, Jansens, Hilde, Mahieu, Ludo, Van Rossom, Paul, Vandewal, Wouter, Lepage, Philippe, Blumental, Sophie, Briquet, Caroline, de Louvain, Catholique, Robbrecht, Dirk, Maton, Pierre, Gabriels, Patrick, Rubic, Zana, Kovacevic, Tanja, Nielsen, Jens Peter, Petersen, Jes Reinholdt, Poorisrisak, Porntiva, Jensen, Lise Heilmann, Laan, Mari, Tamm, Eda, Matsinen, Maire, Rummukainen, Maija-Liisa, Gajdos, Vincent, Olivier, Romain, Le Maréchal, Flore, Martinot, Alain, Prot-Labarthe, Sonia, Lorrot, Mathie, Orbach, Daniel, Pagava, Karaman, Hufnagel, Markus, Knuf, Markus, Schlag, Stephanie A. A., Liese, Johannes, Renner, Lorna, Enimil, Anthony, Awunyo, Marah, Syridou, Garyfallia, Spyridis, Nikos, Critselis, Elena, Kouni, Sofia, Mougkou, Katerina, Ladomenou, Fani, Gkentzi, Despoina, Iosifidis, Elias, Roilides, Emmanuel, Sahu, Suneeta, Murki, Srinivas, Malviya, Manoj, Kalavalapalli, Durga Bhavani, Singh, Sanjeev, Singhal, Tanu, Garg, Garima, Garg, Pankaj, Kler, Neelam, Soltani, Jafar, Jafarpour, Zahra, Pouladfar, Gholamreza, Nicolini, Giangiacomo, Montagnani, Carlotta, Galli, Luisa, Esposito, Susanna, Donaʼ, Daniele, Giaquinto, Carlo, Borgia, Eleonora, DʼArgenio, Patrizia, De Luca, Maia, Centenari, Chiara, Raka, Lul, Omar, Abeer, Al-Mousa, Haifaa, Mozgis, Dzintars, Sviestina, Inese, Burokiene, Sigita, Usonis, Vytautas, Tavchioska, Gabriela, Hargadon-Lowe, Antonia, Zarb, Peter, Borg, Michael A., González Lozano, Carlos Agustín, Zárate Castañon, Patricia, Cancino, Martha E., McCullagh, Bernadette, McCorry, Ann, Gormley, Cairine, Al Maskari, Zaina, Al-Jardani, Amina, Pluta, Magdalena, Rodrigues, Fernanda, Brett, Ana, Esteves, Isabel, Marques, Laura, Ali AlAjmi, Jameela, Claudia Cambrea, Simona, Rashed, Asia N., Mubarak Al Azmi, Aeshah Abdu, Chan, Si Min, Isa, Mas Suhaila, Najdenov, Peter, Čižman, Milan, Unuk, Sibila, Finlayson, Heather, Dramowski, Angela, Maté-Cano, Irene, Soto, Beatriz, Calvo, Cristina, Santiago, Begoña, Saavedra-Lozano, Jesus, Bustinza, Amaya, Escosa-García, Luis, Ureta, Noelia, Tagarro, Alfredo, Barrero, Pedro Terol, Rincon-Lopez, Elena Maria, Abubakar, Ismaela, Aston, Jeff, Heginbothom, Maggie, Satodia, Prakash, Garbash, Mehdi, Johnson, Alison, Sharpe, David, Barton, Christopher, Menson, Esse, Arenas-Lopez, Sara, Luck, Suzanne, Doerholt, Katja, McMaster, Paddy, Caldwell, Neil A., Lunn, Andrew, Drysdale, Simon B., Howe, Rachel, Scorrer, Tim, Gahleitner, Florian, Gupta, Richa, Nash, Clare, Alexander, John, Raman, Mala, Bell, Emily, Rajagopal, Veena, Kohlhoff, Stephan, Cox, Elaine, and Zaoutis, Theoklis

Published
2016
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8. Multisystem inflammatory syndrome in children occurred in one of four thousand children with severe acute respiratory syndrome coronavirus 2

Author

Holm, Mette, primary, Hartling, Ulla Birgitte, additional, Schmidt, Lisbeth Samsø, additional, Glenthøj, Jonathan Peter, additional, Kruse, Alexandra, additional, Rytter, Maren Heilskov, additional, Lindhard, Morten Søndergaard, additional, Lawaetz, Marie Cecilie, additional, Zaharov, Tatjana, additional, Petersen, Jens Jakob, additional, Andersen, Rikke Moeller, additional, Lemvik, Grethe, additional, Marcinski, Pawel, additional, Thaarup, Jesper, additional, Jensen, Lise Heilmann, additional, Borch, Luise, additional, Nielsen, Allan Bybeck, additional, Vissing, Nadja Hawwa, additional, Schmiegelow, Kjeld, additional, and Nygaard, Ulrikka, additional

Published
2021
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9. Acute neonatal myocarditis with cardiogenic shock caused by enterovirus infection

Author

Rahimi, Hanna, Sultan, Tamo, Idorn, Lars, and Jensen, Lise Heilmann

Subjects
Male, Shock, Cardiogenic/etiology, Echocardiography, Enterovirus Infections/complications, Heart Ventricles, Infant, Newborn, Humans, Myocarditis/complications
Abstract

In this case report, a 16-days-old boy presented with reduced feeding, vomiting, respiratory distress and pallor. He developed cardiogenic shock with cardiac arrest and was resuscitated. Echocardiography showed reduced left ventricular systolic function and he was diagnosed with enterovirus myocarditis since enterovirus RNA was found in the blood by polymerase chain reaction. After one month of hospitalization, the patient was discharged without any apparent sequelae. The condition is rare but associated with a high mortality. Early diagnosis and initiation of treatment is essential for survival.

Published
2021

10. Akut neonatal myokarditis med kardiogent shock forårsaget af enterovirusinfektion

Author

Rahimi, Hanna, Sultan, Tamo, Idorn, Lars, Jensen, Lise Heilmann, Rahimi, Hanna, Sultan, Tamo, Idorn, Lars, and Jensen, Lise Heilmann

Abstract

In this case report, a 16-days-old boy presented with reduced feeding, vomiting, respiratory distress and pallor. He developed cardiogenic shock with cardiac arrest and was resuscitated. Echocardiography showed reduced left ventricular systolic function and he was diagnosed with enterovirus myocarditis since enterovirus RNA was found in the blood by polymerase chain reaction. After one month of hospitalization, the patient was discharged without any apparent sequelae. The condition is rare but associated with a high mortality. Early diagnosis and initiation of treatment is essential for survival.

Published
2021

11. Multisystem inflammatory syndrome in children occurred in one of four thousand children with severe acute respiratory syndrome coronavirus 2

Author

Holm, Mette, Hartling, Ulla Birgitte, Schmidt, Lisbeth Samsø, Glenthøj, Jonathan Peter, Kruse, Alexandra, Rytter, Maren Heilskov, Lindhard, Morten Søndergaard, Lawaetz, Marie Cecilie, Zaharov, Tatjana, Petersen, Jens Jakob, Andersen, Rikke Moeller, Lemvik, Grethe, Marcinski, Pawel, Thaarup, Jesper, Jensen, Lise Heilmann, Borch, Luise, Nielsen, Allan Bybeck, Vissing, Nadja Hawwa, Schmiegelow, Kjeld, Nygaard, Ulrikka, Holm, Mette, Hartling, Ulla Birgitte, Schmidt, Lisbeth Samsø, Glenthøj, Jonathan Peter, Kruse, Alexandra, Rytter, Maren Heilskov, Lindhard, Morten Søndergaard, Lawaetz, Marie Cecilie, Zaharov, Tatjana, Petersen, Jens Jakob, Andersen, Rikke Moeller, Lemvik, Grethe, Marcinski, Pawel, Thaarup, Jesper, Jensen, Lise Heilmann, Borch, Luise, Nielsen, Allan Bybeck, Vissing, Nadja Hawwa, Schmiegelow, Kjeld, and Nygaard, Ulrikka

Published
2021

12. Prevalence of SARS-CoV-2-Antibodies in Danish Children and Adults

Author

Rytter, Maren J.H., Nygaard, Ulrikka, Mandic, Ida Nikoline, Glenthøj, Jonathan Peter, Schmidt, Lisbeth Samsø, Cortes, Dina, Smith, Birgitte, Zaharov, Tatjana, Søndergaard, Mia Johanna, Lawaetz, Marie Cecilie, Saekmose, Susanne, Jensen, Lise Heilmann, Schmiegelow, Kjeld, Kristensen, Kim, Rytter, Maren J.H., Nygaard, Ulrikka, Mandic, Ida Nikoline, Glenthøj, Jonathan Peter, Schmidt, Lisbeth Samsø, Cortes, Dina, Smith, Birgitte, Zaharov, Tatjana, Søndergaard, Mia Johanna, Lawaetz, Marie Cecilie, Saekmose, Susanne, Jensen, Lise Heilmann, Schmiegelow, Kjeld, and Kristensen, Kim

Abstract

In Denmark, severe acute respiratory syndrome coronavirus 2 antibodies were assessed in a cross-sectional study among 1033 children visiting pediatric departments and 750 blood donors in June 2020, using a point-of-care test. Antibodies were detected in 17 children (1.6%) and 15 blood donors (2.0%) (P = 0.58). In conclusion, children and adults were infected to a similar low degree.

Published
2021

13. The Need for Hospitalization due to SARS-CoV-2 in Children:A Population-based Estimate

Author

Hartling, Ulla Birgitte, Holm, Mette, Glenthoej, Jonathan Peter, Cortes, Dina, Kruse, Alexandra, Schmidt, Lisbeth Samsø, Lindhard, Morten Søndergaard, Heilskov Rytter, Maren Johanne, Zaharov, Tatjana, Petersen, Jens Jakob Herrche, Andersen, Rikke Møller, Lemvik, Grethe, Nissen, Signe Koch, Marcinski, Pawel Andrej, Thaarup, Jesper, Jensen, Lise Heilmann, Lawaetz, Marie Cecilie, Borch, Luise, Vissing, Nadja Hawwa, Schmiegelow, Kjeld, Nygaard, Ulrikka, Hartling, Ulla Birgitte, Holm, Mette, Glenthoej, Jonathan Peter, Cortes, Dina, Kruse, Alexandra, Schmidt, Lisbeth Samsø, Lindhard, Morten Søndergaard, Heilskov Rytter, Maren Johanne, Zaharov, Tatjana, Petersen, Jens Jakob Herrche, Andersen, Rikke Møller, Lemvik, Grethe, Nissen, Signe Koch, Marcinski, Pawel Andrej, Thaarup, Jesper, Jensen, Lise Heilmann, Lawaetz, Marie Cecilie, Borch, Luise, Vissing, Nadja Hawwa, Schmiegelow, Kjeld, and Nygaard, Ulrikka

Published
2021

14. The Need for Hospitalization due to SARS-CoV-2 in Children: A Population-based Estimate

Author

Hartling, Ulla Birgitte, primary, Holm, Mette, additional, Glenthoej, Jonathan Peter, additional, Cortes, Dina, additional, Kruse, Alexandra, additional, Schmidt, Lisbeth Samsø, additional, Lindhard, Morten Søndergaard, additional, Heilskov Rytter, Maren Johanne, additional, Zaharov, Tatjana, additional, Petersen, Jens Jakob Herrche, additional, Andersen, Rikke Møller, additional, Lemvik, Grethe, additional, Nissen, Signe Koch, additional, Marcinski, Pawel Andrej, additional, Thaarup, Jesper, additional, Jensen, Lise Heilmann, additional, Lawaetz, Marie Cecilie, additional, Borch, Luise, additional, Vissing, Nadja Hawwa, additional, Schmiegelow, Kjeld, additional, and Nygaard, Ulrikka, additional

Published
2021
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15. High Rates of Prescribing Antimicrobials for Prophylaxis in Children and Neonates: Results From the Antibiotic Resistance and Prescribing in European Children Point Prevalence Survey

Author

Hufnagel, Markus Versporten, Ann Bielicki, Julia Drapier, Nico Sherland, Mike Goossens, Herman Maria Calle, Graciela and Clark, Julia Cooper, Celia Blyth, Christopher C. and Francis, Joshua Reginald Alsalman, Jameela Jansen, Hilde and Mahieu, Ludo Van Rossom, Paul Vandewal, Wouter Lepage, Philippe Blumental, Sophie Briquet, Caroline Robbrecht, Dirk and Maton, Pierre Gabriels, Patrick Rubic, Zana Kovacevic, Tanja Nielsen, Jens Peter Petersen, Jes Reinholdt and Poorisrisak, Porntiva Jensen, Lise Heilmann Laan, Mari Tamm, Eda Matsinen, Maire Rummukainen, Maija-Liisa Gajdos, Vincent and Olivier, Romain Le Marechal, Flore Martinot, Alain and Dubos, Francois Lagree, Marion Prot-Labarthe, Sonia Lorrot, Mathie Orbach, Daniel Pagava, Karaman Knuf, Markus and Schlag, Stephanie A. A. Liese, Johannes Renner, Lorna and Enimil, Anthony Awunyo, Marah Syridou, Garyfallia Spyridis, Nikos Critselis, Elena Kouni, Sofia Mougkou, Katerina and Ladomenou, Fani Gkentzi, Despoina Iosifidis, Elias Roilides, Emmanuel Sahu, Suneeta Murki, Srinivas Malviya, Manoj and Kalavalapalli, Durga Bhavani Singh, Sanjeev Singhal, Tanu and Garg, Garima Garg, Pankaj Kler, Neelam Soltani, Jafar and Jafarpour, Zahra Pouladfar, Gholamreza Nicolini, Giangiacomo and Montagnani, Carlotta Galli, Luisa Esposito, Susanna Tenconi, Rossana Lo Vecchio, Andrea Dona, Daniele Giaquinto, Carlo and Borgia, Eleonora D'Argenio, Patrizia De Luca, Maia and Centenari, Chiara Raka, Lul Raka, Denis Omar, Abeer and Al-Mousa, Haifaa Mozgis, Dzintars Sviestina, Inese and Burokiene, Sigita Usonis, Vytautas Tavchioska, Gabriela and Hargadon-Lowe, Antonia Zarb, Peter Borg, Michael A. Gonzalez Lozano, Carlos Agustin Zarate Castanon, Patricia Cancino, Martha E. McCullagh, Bernadette McCorry, Ann Gormley, Cairine and Al Maskari, Zaina Al-Jardani, Amina Pluta, Magdalena and Rodrigues, Fernanda Brett, Ana Esteves, Isabel Marques, Laura AlAjmi, Jameela Ali Cambrea, Simona Claudia Rashed, Asia N. Al Azmi, Aeshah Abdu Mubarak Chan, Si Min Isa, Mas Suhaila Najdenov, Peter Cizman, Milan Unuk, Sibila and Finlayson, Heather Dramowski, Angela Mate-Cano, Irene Soto, Beatriz Calvo, Cristina Santiago, Begona Saavedra-Lozano, Jesus Bustinza, Amaya Escosa-Garcia, Luis Ureta, Noelia and Lopez-Varela, Elisa Rojo, Pablo Tagarro, Alfredo Terol Barrero, Pedro Maria Rincon-Lopez, Elena Abubakar, Ismaela and Aston, Jeff Patel, Mitul Russell, Alison Bedford and Heginbothom, Maggie Satodia, Prakash Garbash, Mehdi Johnson, Alison Sharpe, David Barton, Christopher Menson, Esse and Arenas-Lopez, Sara Luck, Suzanne Doerholt, Katja McMaster, Paddy Caldwell, Neil A. Lunn, Andrew Drysdale, Simon B. and Howe, Rachel Scorrer, Tim Gahleitner, Florian Gupta, Richa and Nash, Clare Alexander, John Raman, Mala Bell, Emily and Rajagopal, Veena Kohlhoff, Stephan Cox, Elaine Nichols, Kristen Zaoutis, Theoklis ARPEC Project Grp

Abstract

Background. This study was conducted to assess the variation in prescription practices for systemic antimicrobial agents used for prophylaxis among pediatric patients hospitalized in 41 countries worldwide. Methods. Using the standardized Antibiotic Resistance and Prescribing in European Children Point Prevalence Survey protocol, a cross-sectional point-prevalence survey was conducted at 226 pediatric hospitals in 41 countries from October 1 to November 30, 2012. Results. Overall, 17 693 pediatric patients were surveyed and 36.7% of them received antibiotics (n = 6499). Of 6818 inpatient children, 2242 (32.9%) received at least 1 antimicrobial for prophylactic use. Of 11 899 prescriptions for antimicrobials, 3400 (28.6%) were provided for prophylactic use. Prophylaxis for medical diseases was the indication in 73.4% of cases (2495 of 3400), whereas 26.6% of prescriptions were for surgical diseases (905 of 3400). In approximately half the cases (48.7% [1656 of 3400]), a combination of 2 or more antimicrobials was prescribed. The use of broad-spectrum antibiotics (BSAs), which included tetracyclines, macrolides, lincosamides, and sulfonamides/trimethoprim, was high (51.8% [1761 of 3400]). Broad-spectrum antibiotic use for medical prophylaxis was more common in Asia (risk ratio [RR], 1.322; 95% confidence interval [CI], 1.202-1.653) and more restricted in Australia (RR, 0.619; 95% CI, 0.521-0.736). Prescription of BSA for surgical prophylaxis also varied according to United Nations region. Finally, a high percentage of surgical patients (79.7% [721 of 905]) received their prophylaxis for longer than 1 day. Conclusions. A high proportion of hospitalized children received prophylactic BSAs. This represents a clear target for quality improvement. Collectively speaking, it is critical to reduce total prophylactic prescribing, BSA use, and prolonged prescription.

Published
2019

16. High rates of prescribing antimicrobials for prophylaxis in children and neonates : results from the antibiotic resistance and prescribing in European children point prevalence survey

Author

Hufnagel, Markus, Versporten, Ann, Bielicki, Julia, Drapier, Nico, Sharland, Mike, Goossens, Herman, Sherland, Mike, Maria Calle, Graciela, Clark, Julia, Cooper, Celia, Blyth, Christopher C., Francis, Joshua Reginald, Alsalman, Jameela, Jansen, Hilde, Mahieu, Ludo, Van Rossom, Paul, Vandewal, Wouter, Lepage, Philippe, Blumental, Sophie, Briquet, Caroline, Robbrecht, Dirk, Maton, Pierre, Gabriels, Patrick, Rubic, Zana, Kovacevic, Tanja, Nielsen, Jens Peter, Petersen, Jes Reinholdt, Poorisrisak, Porntiva, Jensen, Lise Heilmann, Laan, Mari, Tamm, Eda, Matsinen, Maire, Rummukainen, Maija-Liisa, Gajdos, Vincent, Olivier, Romain, Le Marechal, Flore, Martinot, Alain, Dubos, Francois, Lagree, Marion, Prot-Labarthe, Sonia, Lorrot, Mathie, Orbach, Daniel, Pagava, Karaman, Knuf, Markus, Schlag, Stephanie A. A., Liese, Johannes, Renner, Lorna, Enimil, Anthony, Awunyo, Marah, Syridou, Garyfallia, Spyridis, Nikos, Critselis, Elena, Kouni, Sofia, Mougkou, Katerina, Ladomenou, Fani, Gkentzi, Despoina, Iosifidis, Elias, Roilides, Emmanuel, Sahu, Suneeta, Murki, Srinivas, Malviya, Manoj, Kalavalapalli, Durga Bhavani, Singh, Sanjeev, Singhal, Tanu, Garg, Garima, Garg, Pankaj, Kler, Neelam, Soltani, Jafar, Jafarpour, Zahra, Pouladfar, Gholamreza, Nicolini, Giangiacomo, Montagnani, Carlotta, Galli, Luisa, Esposito, Susanna, Tenconi, Rossana, Lo Vecchio, Andrea, Dona, Daniele, Giaquinto, Carlo, Borgia, Eleonora, D'Argenio, Patrizia, De Luca, Maia, Centenari, Chiara, Raka, Lul, Raka, Denis, Omar, Abeer, Al-Mousa, Haifaa, Mozgis, Dzintars, Sviestina, Inese, Burokiene, Sigita, Usonis, Vytautas, Tavchioska, Gabriela, Hargadon-Lowe, Antonia, Zarb, Peter, Borg, Michael A., Gonzalez Lozano, Carlos Agustin, Zarate Castanon, Patricia, Cancino, Martha E., McCullagh, Bernadette, McCorry, Ann, Gormley, Cairine, Al Maskari, Zaina, Al-Jardani, Amina, Pluta, Magdalena, Rodrigues, Fernanda, Brett, Ana, Esteves, Isabel, Marques, Laura, AlAjmi, Jameela Ali, Cambrea, Simona Claudia, Rashed, Asia N., Al Azmi, Aeshah Abdu Mubarak, Chan, Si Min, Isa, Mas Suhaila, Najdenov, Peter, Cizman, Milan, Unuk, Sibila, Finlayson, Heather, Dramowski, Angela, Mate-Cano, Irene, Soto, Beatriz, Calvo, Cristina, Santiago, Begona, Saavedra-Lozano, Jesus, Bustinza, Amaya, Escosa-Garcia, Luis, Ureta, Noelia, Lopez-Varela, Elisa, Rojo, Pablo, Tagarro, Alfredo, Terol Barrero, Pedro, Maria Rincon-Lopez, Elena, Abubakar, Ismaela, Aston, Jeff, Patel, Mitul, Russell, Alison Bedford, Heginbothom, Maggie, Satodia, Prakash, Garbash, Mehdi, Johnson, Alison, Sharpe, David, Barton, Christopher, Menson, Esse, Arenas-Lopez, Sara, Luck, Suzanne, Doerholt, Katja, McMaster, Paddy, Caldwell, Neil A., Lunn, Andrew, Drysdale, Simon B., Howe, Rachel, Scorrer, Tim, Gahleitner, Florian, Gupta, Richa, Nash, Clare, Alexander, John, Raman, Mala, Bell, Emily, Rajagopal, Veena, Kohlhoff, Stephan, Cox, Elaine, Nichols, Kristen, Zaoutis, Theoklis, Mahieu, Ludo, and ARPEC Project Grp

Subjects
antimicrobials, inpatients, pediatrics, point-prevalence survey, prophylactic prescribing, Point-prevalence survey, Male, medicine.medical_specialty, medicine.drug_class, Antibiotics, Pediatrics, Drug Prescriptions, 03 medical and health sciences, Surgical prophylaxis, 0302 clinical medicine, Pharmacotherapy, Antibiotic resistance, Anti-Infective Agents, 030225 pediatrics, Internal medicine, medicine, Prevalence, Humans, Medical prescription, Antimicrobials, Inpatients, Prophylactic prescribing, 0303 health sciences, 030306 microbiology, business.industry, Pharmacology. Therapy, Infant, Newborn, Drug Resistance, Microbial, General Medicine, Antibiotic Prophylaxis, Hospitals, Pediatric, Prophylactic Surgery, Drug Utilization, Anti-Bacterial Agents, Hospitalization, Infectious Diseases, Cross-Sectional Studies, Relative risk, Health Care Surveys, Pediatrics, Perinatology and Child Health, Chemoprophylaxis, Drug Therapy, Combination, Female, Human medicine, business, Child, Hospitalized
Abstract

Background: This study was conducted to assess the variation in prescription practices for systemic antimicrobial agents used for prophylaxis among pediatric patients hospitalized in 41 countries worldwide.Methods: Using the standardized Antibiotic Resistance and Prescribing in European Children Point Prevalence Survey protocol, a cross-sectional point-prevalence survey was conducted at 226 pediatric hospitals in 41 countries from October 1 to November 30, 2012.Results: Overall, 17693 pediatric patients were surveyed and 36.7% of them received antibiotics (n = 6499). Of 6818 inpatient children, 2242 (32.9%) received at least 1 antimicrobial for prophylactic use. Of 11899 prescriptions for antimicrobials, 3400 (28.6%) were provided for prophylactic use. Prophylaxis for medical diseases was the indication in 73.4% of cases (2495 of 3400), whereas 26.6% of prescriptions were for surgical diseases (905 of 3400). In approximately half the cases (48.7% [1656 of 3400]), a combination of 2 or more antimicrobials was prescribed. The use of broad-spectrum antibiotics (BSAs), which included tetracyclines, macrolides, lincosamides, and sulfonamides/trimethoprim, was high (51.8% [1761 of 3400]). Broad-spectrum antibiotic use for medical prophylaxis was more common in Asia (risk ratio [RR], 1.322; 95% confidence interval [CI], 1.202-1.653) and more restricted in Australia (RR, 0.619; 95% CI, 0.521-0.736). Prescription of BSA for surgical prophylaxis also varied according to United Nations region. Finally, a high percentage of surgical patients (79.7% [721 of 905]) received their prophylaxis for longer than 1 day.Conclusions: A high proportion of hospitalized children received prophylactic BSAs. This represents a clear target for quality improvement. Collectively speaking, it is critical to reduce total prophylactic prescribing, BSA use, and prolonged prescription.

Published
2019

17. Children hospitalised with gastroenteritis before and during the COVID‐19 pandemic.

Author

Saidian, Hamida, Daugberg, Rie, Jensen, Lise Heilmann, Schoos, Ann‐Marie Malby, and Rytter, Maren Johanne Heilskov

Subjects
*GASTROENTERITIS, *HOSPITAL admission & discharge, *PANDEMICS, *ACQUISITION of data, *PEDIATRICS
Abstract

Aims Methods Results Conclusion The COVID‐19 pandemic altered the pattern of many paediatric infections. We aimed to assess the incidence and characteristics of children hospitalised with gastroenteritis during the early and the late pandemic, relative to previous years.In a retrospective study, we collected data from patient files of children aged 1 month to 5 years, admitted with gastroenteritis to a paediatric department in Denmark during January–June, of 2017 to 2021, comparing incidence rates and clinical features in the early pandemic (March to June 2020), and late pandemic period (January to June 2021), to similar pre‐pandemic months.In the early pandemic, admission rates per 1000 children/month declined to 0.5 (95% CI: 0.3–0.6) from pre‐pandemic rates of 1.6 (95% CI: 1.4–1.7) (p < 0.0001) and increased in the late pandemic to 2.2 (95% CI: 1.9–2.6) (p = 0.006). Children admitted in the late pandemic period were older than those admitted previously.A resurgence of gastroenteritis in children occurred in the spring of 2021, with higher hospital admission rates of children, who were older, but not more severely ill than previously. [ABSTRACT FROM AUTHOR]

Published
2024
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19. [Recurrent meningococcal infection in a young woman witha mutation in the C8B gene].

Author

Andersen UØ, Bay JT, and Jensen LH

Subjects
Female, Humans, Mutation, Meningitis, Meningococcal diagnosis, Meningococcal Infections diagnosis, Meningococcal Infections drug therapy, Meningococcal Vaccines, Neisseria meningitidis genetics
Abstract

This is a case report of recurrent meningococcal infection in a young woman. She had no positive microbiological findings but was serologically diagnosed with the meningococcal antibody test. Investigation of the complement system showed no function of the terminal pathway. Further genetical analysis revealed a pathogen mutation in the C8B gene in the patient and her sister. They were both immunised with meningococcal vaccines. Complement deficiencies are rare but potentially fatal. Workup for complement deficiency is important for correct acute and prophylactic treatment.

Published
2022

20. [Acute neonatal myocarditis with cardiogenic shock caused by enterovirus infection].

Author

Rahimi H, Sultan T, Idorn L, and Jensen LH

Subjects
Echocardiography, Heart Ventricles, Humans, Infant, Newborn, Male, Shock, Cardiogenic etiology, Enterovirus Infections complications, Enterovirus Infections diagnosis, Myocarditis complications, Myocarditis diagnosis, Myocarditis drug therapy
Abstract

In this case report, a 16-days-old boy presented with reduced feeding, vomiting, respiratory distress and pallor. He developed cardiogenic shock with cardiac arrest and was resuscitated. Echocardiography showed reduced left ventricular systolic function and he was diagnosed with enterovirus myocarditis since enterovirus RNA was found in the blood by polymerase chain reaction. After one month of hospitalization, the patient was discharged without any apparent sequelae. The condition is rare but associated with a high mortality. Early diagnosis and initiation of treatment is essential for survival.

Published
2021

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