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Your search keyword '"Jensen, Anja T.R."' showing total 18 results
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18 results on '"Jensen, Anja T.R."'

3. Plasmodium falciparum erythrocyte membrane protein 1 variants induce cell swelling and disrupt the blood–brain barrier in cerebral malaria

Author

Adams, Yvonne, primary, Olsen, Rebecca W., additional, Bengtsson, Anja, additional, Dalgaard, Nanna, additional, Zdioruk, Mykola, additional, Satpathi, Sanghamitra, additional, Behera, Prativa K., additional, Sahu, Praveen K., additional, Lawler, Sean E., additional, Qvortrup, Klaus, additional, Wassmer, Samuel C., additional, and Jensen, Anja T.R., additional

Published
2021
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5. Integrin activation enables simultaneous and sensitive detection of functional virus-specific CD4+ and CD8+ T cells

Author

Schöllhorn, Anna, primary, Schuhmacher, Juliane, additional, Besedovsky, Luciana, additional, Fendel, Rolf, additional, Jensen, Anja T.R., additional, Stevanović, Stefan, additional, Lange, Tanja, additional, Rammensee, Hans-Georg, additional, Born, Jan, additional, Gouttefangeas, Cécile, additional, and Dimitrov, Stoyan, additional

Published
2020
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6. Occurrence of the Southeast Asian/South American SVMNT haplotype of the chloroquine-resistance transporter gene in plasmodium falciparum in Tanzania

Author

Alifrangis, Michael, Dalgaard, Michael B., Lusingu, John P., Vestergaard, Lasse S., Staalsoe, Trine, Jensen, Anja T.R., Enevold, Anders, Ronn, Anita M., Khalil, Insaf F., Warhurst, David C., Lemnge, Martha M., Theander, Thor G., and Bygbjerg, Ib C.

Subjects
Plasmodium falciparum -- Research, Plasmodium falciparum -- Genetic aspects, Plasmodium falciparum -- Care and treatment, Chloroquine -- Usage, Chloroquine -- Health aspects, Chloroquine -- Research, Haplotypes -- Analysis, Health
Published
2006

8. Blood outgrowth endothelial cells (BOECs) as a novel tool for studying adhesion of Plasmodium falciparum-infected erythrocytes

Author

Ecklu-Mensah, Gertrude, Olsen, Rebecca W., Bengtsson, Anja, Ofori, Michael F., Hviid, Lars, Jensen, Anja T.R., Adams, Yvonne, Ecklu-Mensah, Gertrude, Olsen, Rebecca W., Bengtsson, Anja, Ofori, Michael F., Hviid, Lars, Jensen, Anja T.R., and Adams, Yvonne

Abstract

The lack of suitable animal models for the study of cytoadhesion of P. falciparum-infected erythrocytes (IEs) has necessitated in vitro studies employing a range of cell lines of either human tumour origin (e.g., BeWo and C32 cells) or non-human origin (e.g., CHO cells). Of the human cells available, many were isolated from adults, or derived from a pool of donors (e.g., HBEC-5i). Here we demonstrate, for the first time, the successful isolation of blood outgrowth endothelial cells (BOECs) from frozen stabilates of peripheral blood mononuclear cells obtained from small-volume peripheral blood samples from paediatric malaria patients. BOECs are a sub-population of human endothelial cells, found within the peripheral blood. We demonstrate that these cells express receptors such as Intercellular Adhesion Molecule 1 (ICAM-1/CD54), Endothelial Protein C Receptor (EPCR/CD201), platelet/endothelial cell adhesion molecule 1 (PECAM-1/CD31), Thrombomodulin (CD141), and support adhesion of P. falciparum IEs.

Published
2018

10. A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection

Author

Zanghì, Gigliola, primary, Vembar, Shruthi S., additional, Baumgarten, Sebastian, additional, Ding, Shuai, additional, Guizetti, Julien, additional, Bryant, Jessica M., additional, Mattei, Denise, additional, Jensen, Anja T.R., additional, Rénia, Laurent, additional, Goh, Yun Shan, additional, Sauerwein, Robert, additional, Hermsen, Cornelus C., additional, Franetich, Jean-François, additional, Bordessoulles, Mallaury, additional, Silvie, Olivier, additional, Soulard, Valérie, additional, Scatton, Olivier, additional, Chen, Patty, additional, Mecheri, Salah, additional, Mazier, Dominique, additional, and Scherf, Artur, additional

Published
2018
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11. Structure-Guided Identification of a Family of Dual Receptor-Binding PfEMP1 that Is Associated with Cerebral Malaria

Author

Lennartz, Frank, primary, Adams, Yvonne, additional, Bengtsson, Anja, additional, Olsen, Rebecca W., additional, Turner, Louise, additional, Ndam, Nicaise T., additional, Ecklu-Mensah, Gertrude, additional, Moussiliou, Azizath, additional, Ofori, Michael F., additional, Gamain, Benoit, additional, Lusingu, John P., additional, Petersen, Jens E.V., additional, Wang, Christian W., additional, Nunes-Silva, Sofia, additional, Jespersen, Jakob S., additional, Lau, Clinton K.Y., additional, Theander, Thor G., additional, Lavstsen, Thomas, additional, Hviid, Lars, additional, Higgins, Matthew K., additional, and Jensen, Anja T.R., additional

Published
2017
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12. A Specific PfEMP1 Is Expressed in P. falciparumSporozoites and Plays a Role in Hepatocyte Infection

Author

Zanghì, Gigliola, Vembar, Shruthi S., Baumgarten, Sebastian, Ding, Shuai, Guizetti, Julien, Bryant, Jessica M., Mattei, Denise, Jensen, Anja T.R., Rénia, Laurent, Goh, Yun Shan, Sauerwein, Robert, Hermsen, Cornelus C., Franetich, Jean-François, Bordessoulles, Mallaury, Silvie, Olivier, Soulard, Valérie, Scatton, Olivier, Chen, Patty, Mecheri, Salah, Mazier, Dominique, and Scherf, Artur

Abstract

Heterochromatin plays a central role in the process of immune evasion, pathogenesis, and transmission of the malaria parasite Plasmodium falciparumduring blood stage infection. Here, we use ChIP sequencing to demonstrate that sporozoites from mosquito salivary glands expand heterochromatin at subtelomeric regions to silence blood-stage-specific genes. Our data also revealed that heterochromatin enrichment is predictive of the transcription status of clonally variant genes members that mediate cytoadhesion in blood stage parasites. A specific member (here called NF54varsporo) of the vargene family remains euchromatic, and the resultant PfEMP1 (NF54_SpzPfEMP1) is expressed at the sporozoite surface. NF54_SpzPfEMP1-specific antibodies efficiently block hepatocyte infection in a strain-specific manner. Furthermore, human volunteers immunized with infective sporozoites developed antibodies against NF54_SpzPfEMP1. Overall, we show that the epigenetic signature of vargenes is reset in mosquito stages. Moreover, the identification of a strain-specific sporozoite PfEMP1 is highly relevant for vaccine design based on sporozoites.

Published
2018
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13. Evidence for the Involvement of VAR2CSA in Pregnancy-associated Malaria

Author

Salanti, Ali, primary, Dahlbäck, Madeleine, additional, Turner, Louise, additional, Nielsen, Morten A., additional, Barfod, Lea, additional, Magistrado, Pamela, additional, Jensen, Anja T.R., additional, Lavstsen, Thomas, additional, Ofori, Michael F., additional, Marsh, Kevin, additional, Hviid, Lars, additional, and Theander, Thor G., additional

Published
2004
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14. Plasmodium falciparum Associated with Severe Childhood Malaria Preferentially Expresses PfEMP1 Encoded by Group A var Genes

Author

Jensen, Anja T.R., primary, Magistrado, Pamela, additional, Sharp, Sarah, additional, Joergensen, Louise, additional, Lavstsen, Thomas, additional, Chiucchiuini, Antonella, additional, Salanti, Ali, additional, Vestergaard, Lasse S., additional, Lusingu, John P., additional, Hermsen, Rob, additional, Sauerwein, Robert, additional, Christensen, Jesper, additional, Nielsen, Morten A., additional, Hviid, Lars, additional, Sutherland, Colin, additional, Staalsoe, Trine, additional, and Theander, Thor G., additional

Published
2004
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18. Novel Plasmodium falciparum malaria vaccines: evidence-based searching for variant surface antigens as candidates for vaccination against pregnancy-associated malaria.

Author

Staalsoe, Trine, Jensen, Anja T.R., Theander, Thor G., and Hviid, Lars

Subjects
*MALARIA, *PLASMODIUM falciparum, *VACCINATION
Abstract

Malaria vaccine development has traditionally concentrated on careful molecular, biochemical, and immunological characterisation of candidate antigens. In contrast, evidence of the importance of identified antigens in immunity to human infection and disease has generally been limited to statistically significant co-variation with protection rather than on demonstration of causal relationships. We have studied the relationship between variant surface antigen-specific antibodies and clinical protection from Plasmodium falciparum malaria in general, and from pregnancy-associated malaria (PAM) in particular, to provide robust evidence of a causal link between the two in order to allow efficient and evidence-based identification of candidate antigens for malaria vaccine development. [Copyright &y& Elsevier]

Published
2003
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