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The success of passive immunization suggests that antibody-based therapies will be effective at controlling malaria. We describe the development of fully human antibodies specific for Plasmodium falciparum by antibody repertoire cloning from phage display libraries generated from immune Gambian adults. Although these novel reagents bind with strong affinity to malaria parasites, it remains unclear if in vitro assays are predictive of functional immunity in humans, due to the lack of suitable animal models permissive for P. falciparum. A potentially useful solution described herein allows the antimalarial efficacy of human antibodies to be determined using rodent malaria parasites transgenic for P. falciparum antigens in mice also transgenic for human Fc-receptors. These human IgG1s cured animals of an otherwise lethal malaria infection, and protection was crucially dependent on human FcγRI. This important finding documents the capacity of FcγRI to mediate potent antimalaria immunity and supports the development of FcγRI-directed therapy for human malaria.

The study seeks to give decisionmakers an unclassified analysis of the nature and intensity of US/Soviet arms competition since World War II and to point out implications for future national security policy. The study places emphasis on the overall indicators of the race and strategic nuclear arms. Scholars have concluded that a quantitative arms race usually leads to war, but a qualitative one does not. The study sets up operational definitions for these type races, and tests the US/Soviet case by charting trends in military personnel, nuclear arms, defense expenditures and fear/hostility.

The study examines the US/Soviet arms relationship by tracing the levels and qualitative changes of force components through the years. Granting the limitations of working with unclassified Western estimates of Soviet forces and of condensing information that would fill several catalogues, it proceeds on the basis that at least a clearer picture may emerge and some myths may be disposed of. Whereas most works on the US/Soviet arms race treat only strategic nuclear arms, this analysis also includes tactical nuclear weapons and general purpose forces.