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6. Catalytically active holo Homo sapiens adenosine deaminase I adopts a closed conformation.

Author

Ma, Minh Thu, Jennings, Maria Rain, Blazeck, John, and Lieberman, Raquel L.

Subjects
*ADENOSINE deaminase, *SEVERE combined immunodeficiency, *HUMAN beings, *CATTLE, *PROTEIN engineering
Abstract

Homo sapiens adenosine deaminase 1 (HsADA1; UniProt P00813) is an immunologically relevant enzyme with roles in T‐cell activation and modulation of adenosine metabolism and signaling. Patients with genetic deficiency in HsADA1 suffer from severe combined immunodeficiency, and HsADA1 is a therapeutic target in hairy cell leukemias. Historically, insights into the catalytic mechanism and the structural attributes of HsADA1 have been derived from studies of its homologs from Bos taurus (BtADA) and Mus musculus (MmADA). Here, the structure of holo HsADA1 is presented, as well as biochemical characterization that confirms its high activity and shows that it is active across a broad pH range. Structurally, holo HsADA1 adopts a closed conformation distinct from the open conformation of holo BtADA. Comparison of holo HsADA1 and MmADA reveals that MmADA also adopts a closed conformation. These findings challenge previous assumptions gleaned from BtADA regarding the conformation of HsADA1 that may be relevant to its immunological interactions, particularly its ability to bind adenosine receptors. From a broader perspective, the structural analysis of HsADA1 presents a cautionary tale for reliance on homologs to make structural inferences relevant to applications such as protein engineering or drug development. [ABSTRACT FROM AUTHOR]

Published
2022
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9. Cnoc (C.)

Author

An Cnoc (C.), Bheirn, Jennings, Maria, Loughlin, Peg, Jennings, Madow, Heneghan, Bridie, Byrne, Maggie May, Mulkeen, Celia, Heneghan, Beesy, Curry, Rosie, Curry, Julia, Jennings, Maido, Loughlin, Peg Mc, Heneghan, Miss Beesy, Heneghan, Miss Bridie, Byrne, Maggie Mary, and Killeen, Mary

Subjects
Irish Travellers (Nomadic people), Historic sites, Schools, local legends, Leprechauns, Cnoc Mhuire, Folk beliefs, Traditional medicine, Knock, Manners and customs, Bread, Dwellings, Supernatural beings, Severe storms, Ringforts, Land use, Cemeteries, Marriage, Proverbs, Weather, Folklore
Abstract

A collection of folklore and local history stories from An Cnoc (C.) (school) (Knock, Co. Mayo), collected as part of the Schools' Folklore Scheme, 1937-1938 under the supervision of teacher Bean Uí Bheirn., Patrons / Jennings, Maria -- Forts / Loughlin, Peg -- Hedge-Schools / Jennings, Madow -- Marriages Long Ago / Jennings, Maria -- My Townland / Heneghan, Bridie -- Bread Long Ago / Byrne, Maggie May -- Clothes Long Ago / Byrne, Maggie May -- Songs Long Ago / Mulkeen, Celia -- Landlords Long Ago / Heneghan, Beesy -- Old Ruins / Curry, Rosie -- Houses Long Ago / Curry, Julia -- Music Long Ago / Jennings, Maido -- The people had a lot of old sayings long ago and it is very seldom you hear them said now. / Jennings, Maido -- Graveyards / Loughlin, Peg Mc -- Weather Signs / Curry, Rosie -- Beggars Long Ago / Heneghan, Beesy -- Fairies / Jennings, Maria -- Names of Our Fields / Curry, Rosie -- Superstitions / Heneghan, Miss Beesy -- Games Long Ago / Heneghan, Miss Bridie -- Cures Long Ago / Heneghan, Bridie -- Leprechaun / Byrne, Maggie Mary -- Mills Long Ago / Heneghan, Bridie -- Shops Long Ago / Jennings, Madow -- Storms of Long Ago / Byrne, Maggie May -- Starch Long Ago / Jennings, Maria -- Flax of Long Ago / Killeen, Mary -- Ghost-Story / Jennings, Madow, Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.

Published
1937
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10. Snow maiden

Author

Jennings, Maria

Subjects
Snow Maiden (Book) -- Book reviews, Books
Published
1980

11. Snow Maiden (Book Review).

Author

Jennings, Maria

Subjects
MYTHOLOGY, FICTION
Abstract

Reviews the book 'Snow Maiden,' adapted by Claudia Fregosi.

Published
1980

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