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Summary: Crimean-Congo hemorrhagic fever virus can cause lethal disease in humans yet there are no approved medical countermeasures. Viral glycoprotein GP38, exclusive to Nairoviridae, is a target of protective antibodies and is a key antigen in preclinical vaccine candidates. Here, we isolate 188 GP38-specific antibodies from human survivors of infection. Competition experiments show that these antibodies bind across 5 distinct antigenic sites, encompassing 11 overlapping regions. Additionally, we show structures of GP38 bound with 9 of these antibodies targeting different antigenic sites. Although these GP38-specific antibodies are non-neutralizing, several display protective efficacy equal to or better than murine antibody 13G8 in two highly stringent rodent models of infection. Together, these data expand our understanding regarding this important viral protein and may inform the development of broadly effective CCHFV antibody therapeutics.

The Explainer Video Project was developed to familiarize management students with evaluating explainer videos for credibility and quality. In addition, it provides students with unique options for creating video content. Today's workplace needs college graduates with entrepreneurial skills applicable to the gig economy enabled by online platforms. The demand for the perpetual creation of new video content generates a need for creators to develop explainer videos. Accordingly, consumers of such content require the necessary skills to evaluate them for credibility and quality. Through the phases of this project, students learn to evaluate explainer videos for quality and credibility and create credible, high-quality explainer videos using a visual communication platform.