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340 results on '"Jenne, Craig N."'

1. Multiphoton intravital microscopy of rodents

Author

Scheele, Colinda L. G. J., Herrmann, David, Yamashita, Erika, Lo Celso, Cristina, Jenne, Craig N., Oktay, Maja H., Entenberg, David, Friedl, Peter, Weigert, Roberto, Meijboom, Franck L. B., Ishii, Masaru, Timpson, Paul, and van Rheenen, Jacco

Published
2022
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5. Gene Expression Profiling in Pediatric Appendicitis

Author

Dhillon, Bhavjinder K., primary, Kortbeek, Simone, additional, Baghela, Arjun, additional, Brindle, Mary, additional, Martin, Dori-Ann, additional, Jenne, Craig N., additional, Vogel, Hans J., additional, Lee, Amy H. Y., additional, Thompson, Graham C., additional, and Hancock, Robert E. W., additional

Published
2024
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6. Discrete and conserved inflammatory signatures drive thrombosis in different organs afterSalmonellainfection

Author

Perez-Toledo, Marisol, primary, Beristain-Covarrubias, Nonantzin, additional, Pillaye, Jamie, additional, Persaud, Ruby R, additional, Marcial-Juarez, Edith, additional, Jossi, Sian E., additional, Hitchcock, Jessica R., additional, Alshayea, Areej, additional, Channell, William M., additional, Lamerton, Rachel E, additional, Kavanagh, Dean P, additional, Carestia, Agostina, additional, Horsnell, William G, additional, Henderson, Ian R., additional, Mackman, Nigel, additional, Clark, Andrew R, additional, Jenne, Craig N, additional, Rayes, Julie, additional, Watson, Steve P., additional, and Cunningham, Adam F., additional

Published
2024
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8. Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity

Author

Zammit, Nathan W., Siggs, Owen M., Gray, Paul E., Horikawa, Keisuke, Langley, David B., Walters, Stacey N., Daley, Stephen R., Loetsch, Claudia, Warren, Joanna, Yap, Jin Yan, Cultrone, Daniele, Russell, Amanda, Malle, Elisabeth K., Villanueva, Jeanette E., Cowley, Mark J., Gayevskiy, Velimir, Dinger, Marcel E., Brink, Robert, Zahra, David, Chaudhri, Geeta, Karupiah, Gunasegaran, Whittle, Belinda, Roots, Carla, Bertram, Edward, Yamada, Michiko, Jeelall, Yogesh, Enders, Anselm, Clifton, Benjamin E., Mabbitt, Peter D., Jackson, Colin J., Watson, Susan R., Jenne, Craig N., Lanier, Lewis L., Wiltshire, Tim, Spitzer, Matthew H., Nolan, Garry P., Schmitz, Frank, Aderem, Alan, Porebski, Benjamin T., Buckle, Ashley M., Abbott, Derek W., Ziegler, John B., Craig, Maria E., Benitez-Aguirre, Paul, Teo, Juliana, Tangye, Stuart G., King, Cecile, Wong, Melanie, Cox, Murray P., Phung, Wilson, Tang, Jia, Sandoval, Wendy, Wertz, Ingrid E., Christ, Daniel, Goodnow, Christopher C., and Grey, Shane T.

Published
2019
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9. Inflammatory Mediators in Intra-abdominal Sepsis

Author

Kirkpatrick, Andrew W., Xiao, Jimmy, Jenne, Craig N., Roberts, Derek J., Coccolini, Federico, Series Editor, Coimbra, Raul, Series Editor, Kirkpatrick, Andrew W, Series Editor, Di Saverio, Salomone, Series Editor, Sartelli, Massimo, editor, Bassetti, Matteo, editor, and Martin-Loeches, Ignacio, editor

Published
2018
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10. Illustrated State‐of‐the‐Art Capsules of the ISTH 2019 Congress in Melbourne, Australia

Author

Ward, Christopher M., Andrews, Robert K., Barco, Stefano, Battinelli, E.M., Boilard, Eric, Bos, Mettine H.A., Chicanne, G., Chuansumrit, Ampaiwan, Conway, Edward M., Curry, N., Cutler, Daniel, Danese, Elisa, De Meyer, Simon F., Del Rio, Jose M., Despotovic, Jenny, Di Paola, Jorge, Eikelboom, John, Emsley, Jonas, Eto, Koji, Fijnvandraat, Karin, Flaumenhaft, Robert, Flick, Matthew, Fuchs, Tobias A., Gomez, Keith, Goto, Shinya, Hamilton, Justin R., Hitchcock, Ian S., Jenne, Craig N., Johnsen, Jill M., Ju, Lining A., Le Gal, Grégoire, Levade, M., Lip, Gregory Y.H., Luyendyk, Jim, Maas, Coen, Magnusson, Maria, Mangin, Pierre, Mast, Alan, McLintock, Claire, Miranda, Sébastien, Nathwani, Amit, Ni, Heyu, Áinle, Fionnuala N., Nilsson, Susie, Ny, Tor, O’Brien, Sarah H., O’Donnell, James S., Payrastre, B., Peter, Karlheinz, Rak, Janusz, Randi, Anna M., Rauova, Lubica, Reinhardt, Christoph, Rodger, Marc, Rondina, Matthew, Schreiber, Karen, Severin, S., Shima, Midori, Spyropoulos, Alex, Stanworth, S.J., Suzuki‐Inoue, Katsue, Thomas, Moumneh, Tsukiji, Nagaharu, Urano, Tetsumei, Valet, C., Vanhoorelbeke, Karen, Verhamme, Peter, Weitz, Jeffrey, Wolberg, Alisa, Zentner, Dominica, and Zhu, Cheng

Published
2019
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12. T-bet–dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow

Author

Jenne, Craig N, Enders, Anselm, Rivera, Richard, Watson, Susan R, Bankovich, Alexander J, Pereira, Joao P, Xu, Ying, Roots, Carla M, Beilke, Joshua N, Banerjee, Arnob, Reiner, Steven L, Miller, Sara A, Weinmann, Amy S, Goodnow, Chris C, Lanier, Lewis L, Cyster, Jason G, and Chun, Jerold

Subjects
Stem Cell Research, Aetiology, 2.1 Biological and endogenous factors, Animals, Bone Marrow Cells, Cell Count, Cell Movement, Ethylnitrosourea, Fingolimod Hydrochloride, Killer Cells, Natural, Lymph Nodes, Lymphocyte Activation, Lysophospholipids, Mice, Mice, Mutant Strains, Mutation, Propylene Glycols, Receptors, Lysosphingolipid, Sphingosine, T-Box Domain Proteins, Medical and Health Sciences, Immunology
Abstract

During a screen for ethylnitrosourea-induced mutations in mice affecting blood natural killer (NK) cells, we identified a strain, designated Duane, in which NK cells were reduced in blood and spleen but increased in lymph nodes (LNs) and bone marrow (BM). The accumulation of NK cells in LNs reflected a decreased ability to exit into lymph. This strain carries a point mutation within Tbx21 (T-bet), which generates a defective protein. Duane NK cells have a 30-fold deficiency in sphingosine-1-phosphate receptor 5 (S1P5) transcript levels, and S1P5-deficient mice exhibit an egress defect similar to Duane. Chromatin immunoprecipitation confirms binding of T-bet to the S1pr5 locus. S1P-deficient mice exhibit a more severe NK cell egress block, and the FTY720-sensitive S1P1 also plays a role in NK cell egress from LNs. S1P5 is not inhibited by CD69, a property that may facilitate trafficking of activated NK cells to effector sites. Finally, the accumulation of NK cells within BM of S1P-deficient mice was associated with reduced numbers in BM sinusoids, suggesting a role for S1P in BM egress. In summary, these findings identify S1P5 as a T-bet-induced gene that is required for NK cell egress from LNs and BM.

Published
2009

14. The actin regulator coronin 1A is mutant in a thymic egress–deficient mouse strain and in a patient with severe combined immunodeficiency

Author

Shiow, Lawrence R, Roadcap, David W, Paris, Kenneth, Watson, Susan R, Grigorova, Irina L, Lebet, Tonya, An, Jinping, Xu, Ying, Jenne, Craig N, Föger, Niko, Sorensen, Ricardo U, Goodnow, Christopher C, Bear, James E, Puck, Jennifer M, and Cyster, Jason G

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, 2.1 Biological and endogenous factors, Aetiology, Actin-Related Protein 2-3 Complex, Actins, Alleles, Amino Acid Substitution, Animals, Cell Movement, Cell Shape, Female, Glutamic Acid, Humans, Lysine, Male, Mice, Mice, Inbred ICR, Mice, Knockout, Microfilament Proteins, Mutation, Severe Combined Immunodeficiency, T-Lymphocytes, Thymus Gland, Immunology, Biochemistry and cell biology
Abstract

Mice carrying the recessive locus for peripheral T cell deficiency (Ptcd) have a block in thymic egress, but the mechanism responsible is undefined. Here we found that Ptcd T cells had an intrinsic migration defect, impaired lymphoid tissue trafficking and irregularly shaped protrusions. Characterization of the Ptcd locus showed a point substitution of lysine for glutamic acid at position 26 in the actin regulator coronin 1A that enhanced its inhibition of the actin regulator Arp2/3 and resulted in its mislocalization from the leading edge of migrating T cells. The discovery of another coronin 1A mutant during an N-ethyl-N-nitrosourea-mutagenesis screen for T cell-lymphopenic mice prompted us to evaluate a T cell-deficient, B cell-sufficient and natural killer cell-sufficient patient with severe combined immunodeficiency, whom we found had mutations in both CORO1A alleles. Our findings establish a function for coronin 1A in T cell egress, identify a surface of coronin involved in Arp2/3 regulation and demonstrate that actin regulation is a biological process defective in human and mouse severe combined immunodeficiency.

Published
2008

16. Utilising the intrinsic fluorescence of pomalidomide for imaging applications.

Author

Brownsey, Duncan K., Gafuik, Christopher J., Kim, Dae-Sun, O'Sullivan, Leonie, Gorobets, Evgueni, Krukowski, Samuel, Turk, Madison, Jenne, Craig N., Mahoney, Douglas J., and Derksen, Darren J.

Subjects
FLUORESCENCE, CELL permeability, HIGH throughput screening (Drug development), FLUORESCENCE microscopy, ENDOCYTOSIS
Abstract

Optimisation of protein degraders requires balancing multiple factors including potency, cell permeability and solubility. Here we show that the fluorescence of pomalidomide can be used in high-throughput screening assays to rapidly assess cellular penetration of degrader candidates. In addition, this technique can be paired with endocytosis inhibitors to gain insight into potential mechanisms of candidates entering a target cell. A model library of pomalidomide conjugates was synthesised and evaluated using high-throughput fluorescence microscopy. This technique based on intrinsic fluorescence can be used to guide rational design of pomalidomide conjugates without the need for additional labels or tags. [ABSTRACT FROM AUTHOR]

Published
2023
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17. Renal immune surveillance and dipeptidase-1 contribute to contrast-induced acute kidney injury

Author

Lau, Arthur, Chung, Hyunjae, Komada, Takanori, Platnich, Jaye M., Sandall, Christina F., Choudhury, Saurav Roy, Chun, Justin, Naumenko, Victor, Surewaard, Bas G.J., Nelson, Michelle C., Ulke-Lemee, Annegret, Beck, Paul L., Benediktsson, Hallgrimur, Jevnikar, Anthony M., Snelgrove, Sarah L., Hickey, Michael J., Senger, Donna L., James, Matthew T., Macdonald, Justin A., Kubes, Paul, Jenne, Craig N., and Muruve, Daniel A.

Subjects
Kidney failure -- Genetic aspects -- Drug therapy, Radiography -- Usage, Contrast media -- Dosage and administration, Health care industry
Abstract

Radiographic contrast agents cause acute kidney injury (AKI), yet the underlying pathogenesis is poorly understood. Nod-like receptor pyrin containing 3-deficient (Nlrp3-deficient) mice displayed reduced epithelial cell injury and inflammation in the kidney in a model of contrast-induced AKI (CI-AKI). Unexpectedly, contrast agents directly induced tubular epithelial cell death in vitro that was not dependent on Nlrp3. Rather, contrast agents activated the canonical Nlrp3 inflammasome in macrophages. Intravital microscopy revealed diatrizoate (DTA) uptake within minutes in perivascular [CX.sub.3][CR1.sup.+] resident phagocytes in the kidney. Following rapid filtration into the tubular luminal space, DTA was reabsorbed and concentrated in tubular epithelial cells via the brush border enzyme dipeptidase-1 in volume-depleted but not euvolemic mice. [LysM-GFP.sup.+] macrophages recruited to the kidney interstitial space ingested contrast material transported from the urine via direct interactions with tubules. CI-AKI was dependent on resident renal phagocytes, IL-1, leukocyte recruitment, and dipeptidase-1. Levels of the inflammasome-related urinary biomarkers IL-18 and caspase-1 were increased immediately following contrast administration in patients undergoing coronary angiography, consistent with the acute renal effects observed in mice. Taken together, these data show that CI-AKI is a multistep process that involves immune surveillance by resident and infiltrating renal phagocytes, Nlrp3-dependent inflammation, and the tubular reabsorption of contrast via dipeptidase-1., Introduction Contrast-induced acute kidney injury (CI-AKI) is caused by iodinated contrast media for diagnostic imaging (1). Most patients with normal kidney function who receive contrast will not experience any renal [...]

Published
2018
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26. Closed Or Open after Source Control Laparotomy for Severe Complicated Intra-Abdominal Sepsis (the COOL trial): study protocol for a randomized controlled trial

Author

Kirkpatrick, Andrew W., Coccolini, Federico, Ansaloni, Luca, Roberts, Derek J., Tolonen, Matti, McKee, Jessica L., Leppaniemi, Ari, Faris, Peter, Doig, Christopher J., Catena, Fausto, Fabian, Timothy, Jenne, Craig N., Chiara, Osvaldo, Kubes, Paul, Manns, Braden, Kluger, Yoram, Fraga, Gustavo P., Pereira, Bruno M., Diaz, Jose J., Sugrue, Michael, Moore, Ernest E., Ren, Jianan, Ball, Chad G., Coimbra, Raul, Balogh, Zsolt J., Abu-Zidan, Fikri M., Dixon, Elijah, Biffl, Walter, MacLean, Anthony, Ball, Ian, Drover, John, McBeth, Paul B., Posadas-Calleja, Juan G., Parry, Neil G., Di Saverio, Salomone, Ordonez, Carlos A., Xiao, Jimmy, Sartelli, Massimo, and for The Closed Or Open after Laparotomy (COOL) after Source Control for Severe Complicated Intra-Abdominal Sepsis Investigators

Published
2018
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27. Getting the invite list right: a discussion of sepsis severity scoring systems in severe complicated intra-abdominal sepsis and randomized trial inclusion criteria

Author

Tolonen, Matti, Coccolini, Federico, Ansaloni, Luca, Sartelli, Massimo, Roberts, Derek J., McKee, Jessica L., Leppaniemi, Ari, Doig, Christopher J., Catena, Fausto, Fabian, Timothy, Jenne, Craig N., Chiara, Osvaldo, Kubes, Paul, Kluger, Yoram, Fraga, Gustavo P., Pereira, Bruno M., Diaz, Jose J., Sugrue, Michael, Moore, Ernest E., Ren, Jianan, Ball, Chad G., Coimbra, Raul, Dixon, Elijah, Biffl, Walter, MacLean, Anthony, McBeth, Paul B., Posadas-Calleja, Juan G., Di Saverio, Salomone, Xiao, Jimmy, Kirkpatrick, Andrew W., and From the Closed Or Open after Laparotomy (COOL) for Source Control in Severe Complicated Intra-Abdominal Sepsis Investigators

Published
2018
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28. Dipeptidase-1 governs renal inflammation during ischemia reperfusion injury

Author

Lau, Arthur, primary, Rahn, Jennifer J., additional, Chappellaz, Mona, additional, Chung, Hyunjae, additional, Benediktsson, Hallgrimur, additional, Bihan, Dominique, additional, von Mässenhausen, Anne, additional, Linkermann, Andreas, additional, Jenne, Craig N., additional, Robbins, Stephen M., additional, Senger, Donna L., additional, Lewis, Ian A., additional, Chun, Justin, additional, and Muruve, Daniel A., additional

Published
2022
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30. Platelet-Mediated NET Release Amplifies Coagulopathy and Drives Lung Pathology During Severe Influenza Infection

Author

Kim, Seok-Joo, primary, Carestia, Agostina, additional, McDonald, Braedon, additional, Zucoloto, Amanda Z., additional, Grosjean, Heidi, additional, Davis, Rachelle P., additional, Turk, Madison, additional, Naumenko, Victor, additional, Antoniak, Silvio, additional, Mackman, Nigel, additional, Abdul-Cader, Mohamed Sarjoon, additional, Abdul-Careem, Mohamed Faizal, additional, Hollenberg, Morley D., additional, and Jenne, Craig N., additional

Published
2021
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36. Additional file 1 of Integration of metabolic and inflammatory mediator profiles as a potential prognostic approach for septic shock in the intensive care unit

Author

Mickiewicz, Beata, Tam, Patrick, Jenne, Craig N, Leger, Caroline, Wong, Josee, Winston, Brent W, Doig, Christopher, Kubes, Paul, and Vogel, Hans J

Abstract

Three-dimensional PCA score scatter plots. Three-dimensional PCA score scatter plots obtained for 37 septic shock patients (red) and 20 ICU controls (green) based on the (A) metabolic data and (B) cytokine/chemokine data. The groups are well clustered along the axes of the three principal components. One septic shock sample is placed outside the sphere that describes the 95% confidence interval of the Hotelling’s T-squared distribution.

Published
2021
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37. Additional file 5 of Integration of metabolic and inflammatory mediator profiles as a potential prognostic approach for septic shock in the intensive care unit

Author

Mickiewicz, Beata, Tam, Patrick, Jenne, Craig N, Leger, Caroline, Wong, Josee, Winston, Brent W, Doig, Christopher, Kubes, Paul, and Vogel, Hans J

Abstract

The receiver operating characteristic (ROC) curves plotted with a decimal logarithmic scale for the horizontal axes. The ROC plots for (A) septic shock patients vs. ICU controls and (B) septic shock nonsurvivors vs. septic shock survivors models based on the metabolomics data, cytokine/chemokine data and the combined dataset (metabolites together with inflammatory mediators), APACHE (acute physiology and chronic health evaluation) and SOFA (sequential organ failure assessment) scores. Black line - fit line, red dashed line - the chance curve (that is the diagonal of the ROC curve when plotted in linear scale).

Published
2021
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40. Additional file 1 of Development of metabolic and inflammatory mediator biomarker phenotyping for early diagnosis and triage of pediatric sepsis

Author

Mickiewicz, Beata, Thompson, Graham C., Blackwood, Jaime, Jenne, Craig N., Winston, Brent W., Vogel, Hans J., and Joffe, Ari R.

Abstract

Supplemental descriptions of methods, statistical modeling, results of subgroups, discussion of the importance of the metabolites and protein mediators of interest (biomarkers) identified, and supplemental references. This file also includes two tables. Table E1. The metabolites (non-targeted 1H NMR spectroscopy and metabolite concentration profiling) and protein mediators (targeted bead-based multiplex assay) detected and quantified. Table E2. Comparison of statistical measures calculated for the supervised OPLS-DA models without excluding outliers from the results presented in the main text of the article. (PDF 307 kb)

Published
2021
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43. Additional file 4 of Integration of metabolic and inflammatory mediator profiles as a potential prognostic approach for septic shock in the intensive care unit

Author

Mickiewicz, Beata, Tam, Patrick, Jenne, Craig N, Leger, Caroline, Wong, Josee, Winston, Brent W, Doig, Christopher, Kubes, Paul, and Vogel, Hans J

Abstract

The OPLS-DA regression coefficient plot. Positive values of coefficients (the upper part of the diagram) indicates increased metabolite or inflammatory mediator concentrations in septic shock nonsurvivor samples while negative values (the lower part of diagram) present a decrease in metabolite or inflammatory mediator concentrations, as compared to the age-sex-matched septic shock survivors. Only significant metabolites are shown (P

Published
2021
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46. Additional file 3 of Integration of metabolic and inflammatory mediator profiles as a potential prognostic approach for septic shock in the intensive care unit

Author

Mickiewicz, Beata, Tam, Patrick, Jenne, Craig N, Leger, Caroline, Wong, Josee, Winston, Brent W, Doig, Christopher, Kubes, Paul, and Vogel, Hans J

Abstract

The summary table. Comparison of statistical measures calculated for the supervised OPLS-DA models without excluding outliers to the results presented in the manuscript.

Published
2021
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