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1. COVID-19 susceptibility and severity risks in a cross-sectional survey of over 500 000 US adults

Author

Yong Wang, Robert Burton, Cecily Vaughn, Miao Zhang, Brooke Rhead, Heather Harris, Spencer C Knight, Shannon R McCurdy, Marie V Coignet, Danny S Park, Genevieve H L Roberts, Nathan D Berkowitz, David Turissini, Karen Delgado, Milos Pavlovic, Asher K Haug Baltzell, Harendra Guturu, Kristin A Rand, Ahna R Girshick, Eurie L Hong, Catherine A Ball, Yambazi Banda, Ke Bi, Marjan Champine, Ross Curtis, Abby Drokhlyansky, Ashley Elrick, Cat Foo, Michael Gaddis, Jialiang Gu, Shannon Hateley, Shea King, Christine Maldonado, Evan McCartney-Melstad, Alexandra McFarland, Patty Miller, Luong Nguyen, Keith Noto, Jingwen Pei, Jenna Petersen, Scott Pew, Chodon Sass, Josh Schraiber, Alisa Sedghifar, Andrey Smelter, Sarah South, and Barry Starr

Subjects
Medicine
Abstract

Objectives The enormous toll of the COVID-19 pandemic has heightened the urgency of collecting and analysing population-scale datasets in real time to monitor and better understand the evolving pandemic. The objectives of this study were to examine the relationship of risk factors to COVID-19 susceptibility and severity and to develop risk models to accurately predict COVID-19 outcomes using rapidly obtained self-reported data.Design A cross-sectional study.Setting AncestryDNA customers in the USA who consented to research.Participants The AncestryDNA COVID-19 Study collected self-reported survey data on symptoms, outcomes, risk factors and exposures for over 563 000 adult individuals in the USA in just under 4 months, including over 4700 COVID-19 cases as measured by a self-reported positive test.Results We replicated previously reported associations between several risk factors and COVID-19 susceptibility and severity outcomes, and additionally found that differences in known exposures accounted for many of the susceptibility associations. A notable exception was elevated susceptibility for men even after adjusting for known exposures and age (adjusted OR=1.36, 95% CI=1.19 to 1.55). We also demonstrated that self-reported data can be used to build accurate risk models to predict individualised COVID-19 susceptibility (area under the curve (AUC)=0.84) and severity outcomes including hospitalisation and critical illness (AUC=0.87 and 0.90, respectively). The risk models achieved robust discriminative performance across different age, sex and genetic ancestry groups within the study.Conclusions The results highlight the value of self-reported epidemiological data to rapidly provide public health insights into the evolving COVID-19 pandemic.

Published
2022
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2. Novel COVID-19 phenotype definitions reveal phenotypically distinct patterns of genetic association and protective effects

Author

Marie V. Coignet, Eurie L. Hong, Sarah South, Miao Zhang, Harendra Guturu, Pei Jingwen, Jialiang Gu, Brooke Rhead, Michael Gaddis, Cecily Vaughn, Luong Ruiz, Nathan Berkowitz, Cat Foo, Ashley Elrick, Christine Maldonado, Ahna R. Girshick, Heather H. Harris, Ke Bi, Marjan Champine, Evan McCartney-Melstad, Spencer C. Knight, Keith Noto, Barry Starr, Milos Pavlovic, David A. Turrisini, Robert Burton, Kristin A. Rand, Ross E. Curtis, Shea King, Andrey Smelter, Karen Delgado, Yambazi Banda, Asher K. Haug Baltzell, Alisa Sedghifar, Raghavendran Partha, Yong Wang, Abby Drokhlyansky, Genevieve H.L. Roberts, Chodon Sass, Jenna Petersen, Patty Miller, Danny S. Park, Catherine A. Ball, and Shannon R. McCurdy

Subjects
education.field_of_study, Coronavirus disease 2019 (COVID-19), business.industry, Population, Genome-wide association study, Bioinformatics, Phenotype, Intensive care unit, law.invention, law, ABO blood group system, Medicine, business, education, Genetic association, Subclinical infection
Abstract

INTRODUCTION PARAGRAPHMultiple large COVID-19 genome-wide association studies (GWAS) have identified reproducible genetic associations indicating that some infection susceptibility and severity risk is heritable.1-5 Most of these studies ascertained COVID-19 cases in medical clinics and hospitals, which can lead to an overrepresentation of cases with severe outcomes, such as hospitalization, intensive care unit admission, or ventilation. Here, we demonstrate the utility and validity of deep phenotyping with self-reported outcomes in a population with a large proportion of mild and subclinical cases. Using these data, we defined eight different phenotypes related to COVID-19 outcomes: four that align with previously studied COVID-19 definitions and four novel definitions that focus on susceptibility given exposure, mild clinical manifestations, and an aggregate score of symptom severity. We assessed replication of 13 previously identified COVID-19 genetic associations with all eight phenotypes and found distinct patterns of association, most notably related to the chr3/SLC6A20/LZTFL1 and chr9/ABO regions. We then performed a discovery GWAS, which suggested some novel phenotypes may better capture protective associations and also identified a novel association in chr11/GALNT18 that reproduced in two fully independent populations.

Published
2021
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3. Patterns of family communication and preferred resources for sharing information among families with a Lynch syndrome diagnosis

Author

Yelena P. Wu, Andrew P. Soisson, Megan Keener, Kimberly A. Kaphingst, Cathryn Koptiuch, Wendy Kohlmann, Ryan Mooney, Priyanka Kanth, Kathryn Szczotka, Jenna Petersen, Lisa Pappas, and Ashley Elrick

Subjects
0301 basic medicine, Proband, Adult, Male, medicine.medical_specialty, congenital, hereditary, and neonatal diseases and abnormalities, Health Knowledge, Attitudes, Practice, Specialty, Family communication, 030105 genetics & heredity, Article, Interviews as Topic, 03 medical and health sciences, 0302 clinical medicine, Patient Education as Topic, medicine, Humans, Family, Genetic Testing, Aged, Information Dissemination, Communication, Communication Barriers, General Medicine, Middle Aged, medicine.disease, Colorectal Neoplasms, Hereditary Nonpolyposis, Lynch syndrome, Test (assessment), 030220 oncology & carcinogenesis, Family medicine, Helpfulness, Mutation (genetic algorithm), Female, Psychology, Patient education
Abstract

Objectives To explore patterns of communication among families with a Lynch syndrome diagnosis and understand what resources could facilitate family communication. Methods 127 probands (i.e., first person in family with identified mutation) and family members participated in semi-structured interviews about: how they learned about the Lynch syndrome diagnosis, with whom they shared genetic test results, confidence in sharing results with other family members, and helpfulness of educational resources. Results Both probands and family members were most likely to share genetic test results with parents and siblings, and least likely to share results with aunts, uncles, and cousins. Most participants felt very confident sharing their test results with family members, but reported that certain topics such as cancer risk were challenging to convey. Probands reported the most helpful resources to be access to a specialty clinic or website, while family members described general printed materials as most helpful. Conclusions Families affected by Lynch syndrome may experience barriers to communication with more distant relatives, and may benefit from receiving specific resources (e.g., websites about Lynch syndrome, print materials) to facilitate family communication. Practice implications Providers could emphasize the need to share information with more distant family members and provide appropriate supportive resources.

Published
2018

4. A Scoundrel's Surrender

Author

Jenna Petersen and Jenna Petersen

Abstract

“For passion, drama and pure escapist fun—read Jenna Petersen!”—Christina DoddJenna Petersen brings her wonderfully passionate Billingham Bastards series—featuring the romantic exploits of the illegitimate sons of a notorious duke, brought together by love and deception—to a roaring conclusion with A Scoundrel's Surrender. In this truly phenomenal historical romance, set amid the excitement and glamour of England's colorful Regency Era, a London gentleman of questionable origins must face the painful truth about his past when the gentle, loving woman his honor once compelled him to abandon comes back into his life. Bestselling author Elizabeth Boyle adores Jenna Petersen's “Passion on every page!” Jacquie D'Alessandro compares her stories to “rich chocolate—decadent, sinful, and utterly delicious.” Surrender to A Scoundrel's Surrender…and find out what everyone is raving about!

Published
2011

5. The Unclaimed Duchess

Author

Jenna Petersen and Jenna Petersen

Abstract

“For passion, drama and pure escapist fun, read Jenna Petersen!”—Christina Dodd, New York Times bestselling author“Jenna Petersen neatly combines equal measures of dangerous intrigue and sexy romance with exceptionally entertaining results.”—Chicago TribuneThe Unclaimed Duchess is the second in popular author Jenna Petersen's passionate new series about the illegitimate sons of a notorious duke brought together by love and deception. No one combines desire, adventure, and danger better than Jenna Peterson—and if you're a fan of the novels of Christina Dodd and Elizabeth Boyle, you will absolutely love The Unclaimed Duchess.

Published
2010

6. Her Notorious Viscount

Author

Jenna Petersen and Jenna Petersen

Subjects
Boxers (Sports)--Fiction
Abstract

Beauty and her beast...Viscount Nicholas Stoneworth is infamous—even being mentioned in the same breath with him is enough to ruin a lady's reputation. Why, the man's spent years in London's underworld pursuing every sort of vice while parlaying his hard muscled body into fame and fortune as a fighter! With his brother's untimely death, Nicholas must assume the title and relearn the civilized ways of the ton... and proper Jane Fenton is more than willing to teach him everything she knows.Circumstances may have forced Jane into the role of ladies'companion, but she knows the danger of associating with a notorious man like Nicholas, a man who could tempt any woman into certain scandal. But her brother disappeared into the same underworld four long years ago, and if she transforms the libertine into a gentleman, he will use his connections to find him. Still, Jane will not—cannot—lose control. She must ignore the promise of sinful pleasure in his eyes... and her own wild desires desperate to break free.

Published
2009

7. What the Duke Desires

Author

Jenna Petersen and Jenna Petersen

Abstract

In What the Duke Desires, Jenna Petersen launches the first installment in her passionate new romance series about the illegitimate sons of a notorious duke brought together by love and deception. The Duke of Billingham must find a proper wife and continue his family's exalted name—but the woman he desires may be the most unsuitable bride of all...

Published
2009

8. Lessons From a Courtesan

Author

Jenna Petersen and Jenna Petersen

Subjects
Married people--Fiction, Courtesans--England--London--Fiction
Abstract

Lesson #1: Every man loves a mystery.A scandalous siren called'Ria'has electrified the ton. Every gentleman in London desires her; every woman envies her. And they are all desperate to know the secrets of the tantalizing, seductively beautiful courtesan. All except Justin, the Earl of Baybary. He knows all about Ria. He learned every inch of her tender skin, every taste of her luscious lips... on their wedding night. Lesson #2: No man can make you lose control... unless you let him.Though theirs was an arranged marrige, still Victoria surrendered to passion and gave herself to Justin completely. When he left her alone the next morning, she swore she would never again let him into her bed. Now, though she has other reasons for returning to the city, she enjoys tormenting Justin, letting him see the way other men lust for her. But keeping herself from him is such exquisite torture... and forgiveness will lead to an ecstasy unbelievably divine.

Published
2008

9. Scandalous

Author

Jenna Petersen and Jenna Petersen

Subjects
Historical fiction, Love stories
Abstract

Katherine Fleming has lived her life without even a hint of indiscretion. So she is devastated to discover the nobleman she's engaged to has a secret he's kept from her: a wife! Suddenly Katherine's enmeshed in a scandal that has the ton buzzing—and forced to accept a most unconventional proposal from the notorious seducer Dominic Mallory, her faithless fiancé's brother… and precisely the sort of rake she has sworn to avoid! Charming and dangerously sensual, Dominic has desired the stunning beauty from the first moment he spied her. Now, with Katherine's reputation in tatters, it's the ideal opportunity to bed her—though it will take wedding vows to do so. But can a rogue be reformed by the unleashed passion of a normally reserved lady? And can a marriage made for all the wrong reasons flame into the love match of the season?

Published
2006

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