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1. Platelet and Monocyte Activation After Transcatheter Aortic Valve Replacement (POTENT-TAVR): A Mechanistic Randomized Trial of Ticagrelor Versus Clopidogrel

Author

Zidar, David A., Al-Kindi, Sadeer, Longenecker, Chris T., Parikh, Sahil A., Gillombardo, Carl B., Funderburg, Nicholas T., Juchnowski, Steven, Huntington, Lauren, Jenkins, Trevor, Nmai, Christopher, Osnard, Michael, Shishebhor, Mehdi, Filby, Steven, Tatsuoka, Curtis, Lederman, Michael M., Blackstone, Eugene, Attizzani, Guilherme, and Simon, Daniel I.

Published
2023
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4. Evaluation of dyspnea of unknown etiology in HIV patients with cardiopulmonary exercise testing and cardiovascular magnetic resonance imaging

Author

Patterson, Andrew J., Sarode, Anuja, Al-Kindi, Sadeer, Shaver, Lauren, Thomas, Rahul, Watson, Evelyn, Alaiti, Mohamad Amer, Liu, Yuchi, Hamilton, Jessie, Seiberlich, Nicole, Rashid, Imran, Gilkeson, Robert, Schilz, Robert, Hoit, Brian, Jenkins, Trevor, Zullo, Melissa, Bossone, Eduardo, Longenecker, Christopher, Simonetti, Orlando, and Rajagopalan, Sanjay

Published
2020
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8. Control of tissue oxygenation by S-nitrosohemoglobin in human subjects

Author

Reynolds, James D., primary, Posina, Kanna, additional, Zhu, Lin, additional, Jenkins, Trevor, additional, Matto, Faisal, additional, Hausladen, Alfred, additional, Kashyap, Vikram, additional, Schilz, Robert, additional, Zhang, Rongli, additional, Mannick, Joan, additional, Klickstein, Lloyd, additional, Premont, Richard T., additional, and Stamler, Jonathan S., additional

Published
2023
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15. Additional file 1 of Evaluation of dyspnea of unknown etiology in HIV patients with cardiopulmonary exercise testing and cardiovascular magnetic resonance imaging

Author

Patterson, Andrew J., Sarode, Anuja, Sadeer Al-Kindi, Shaver, Lauren, Thomas, Rahul, Watson, Evelyn, Alaiti, Mohamad Amer, Yuchi Liu, Hamilton, Jessie, Seiberlich, Nicole, Rashid, Imran, Gilkeson, Robert, Schilz, Robert, Hoit, Brian, Jenkins, Trevor, Zullo, Melissa, Bossone, Eduardo, Longenecker, Christopher, Simonetti, Orlando, and Rajagopalan, Sanjay

Subjects
animal structures, genetic structures, cardiovascular system, cardiovascular diseases
Abstract

Additional file 1 Figure S1 Bland Altman analysis of right ventricular ejection fraction (RVEF) and left ventricular ejection fraction (LVEF) contractile reserve.

Published
2020
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16. Additional file 3 of Evaluation of dyspnea of unknown etiology in HIV patients with cardiopulmonary exercise testing and cardiovascular magnetic resonance imaging

Author

Patterson, Andrew J., Sarode, Anuja, Sadeer Al-Kindi, Shaver, Lauren, Thomas, Rahul, Watson, Evelyn, Alaiti, Mohamad Amer, Yuchi Liu, Hamilton, Jessie, Seiberlich, Nicole, Rashid, Imran, Gilkeson, Robert, Schilz, Robert, Hoit, Brian, Jenkins, Trevor, Zullo, Melissa, Bossone, Eduardo, Longenecker, Christopher, Simonetti, Orlando, and Rajagopalan, Sanjay

Abstract

Additional file 3 Table S1 Pearson Correlation Coefficients

Published
2020
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17. PLATELET AND MONOCYTE ACTIVATION AFTER TRANSCATHETER AORTIC VALVE REPLACEMENT (POTENT-TAVR): A RANDOMIZED CONTROLLED TRIAL OF TICAGRELOR VERSUS CLOPIDOGREL BEFORE TAVR

Author

Zidar, David Alexander, primary, Al-Kindi, Sadeer, additional, Main, Anthony, additional, Osnard, Michael, additional, Tashtish, Nour, additional, Parikh, Sahil, additional, Funderburg, Nicholas, additional, Juchnowski, Steven, additional, Longenecker, Christopher, additional, Jenkins, Trevor, additional, Nmai, Christopher, additional, Tatsuoka, Curtis, additional, Costa, Marco, additional, Blackstone, Eugene, additional, Lederman, Michael, additional, Attizzani, Guilherme, additional, and Simon, Daniel I., additional

Published
2020
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18. The Influence of Exercise on Cardiovascular Health in Sedentary Adults with HIV

Author

Webel, Allison R., Perazzo, Joseph, Longenecker, Christopher T., Jenkins, Trevor, Sattar, Abdus, Rodriguez, Margaret, Schreiner, Nate, and Josephson, Richard A.

Subjects
Male, Computed Tomography Angiography, Calcinosis, HIV Infections, Middle Aged, Coronary Vessels, Article, CD4 Lymphocyte Count, Wearable Electronic Devices, Cross-Sectional Studies, Oxygen Consumption, Cardiorespiratory Fitness, Accelerometry, Exercise Test, Humans, Female, Insulin Resistance, Sedentary Behavior, Exercise
Abstract

Lifestyle physical activity (ie, moderate physical activity during routine daily activities most days of the week) may benefit human immunodeficiency virus (HIV)-positive adults who are at high risk for cardiovascular disease.The aims of this study were to describe lifestyle physical activity patterns in HIV-positive adults and to examine the influence of lifestyle physical activity on markers of cardiovascular health. Our secondary objective was to compare these relationships between HIV-positive adults and well-matched HIV-uninfected adults.A total of 109 HIV-positive adults and 20 control participants wore an ActiGraph accelerometer, completed a maximal graded cardiopulmonary exercise test, completed a coronary computed tomography, completed anthropomorphic measures, and had lipids and measures of insulin resistance measured from peripheral blood.Participants (N = 129) had a mean age of 52 ± 7.3 years, 64% were male (n = 82), and 88% were African American (n = 112). On average, HIV-positive participants engaged in 33 minutes of moderate-to-vigorous physical activity per day (interquartile range, 17-55 minutes) compared with 48 minutes in controls (interquartile range, 30-62 minutes, P = .05). Human immunodeficiency virus-positive adults had poor fitness (peak oxygen uptake [VO2], 16.8 ± 5.2 mL/min per kg; and a ventilatory efficiency, 33.1 [4.6]). A marker of HIV disease (current CD4+ T cell) was associated with reduced peak VO2 (r = -0.20, P.05) and increased insulin resistance (r = 0.25, P.01) but not with physical activity or other markers of cardiovascular health (P ≥ 0.05). After controlling for age, gender, body mass index, and HIV status, physical activity was not significantly associated with peak VO2 or ventilatory efficiency.Human immunodeficiency virus-positive adults have poor physical activity patterns and diminished cardiovascular health. Future longitudinal studies should examine whether HIV infection blunts the beneficial effects of physical activity on cardiovascular health.

Published
2018

21. EVALUATION OF HIV-ASSOCIATED DYSPNEA USING CARDIAC MAGNETIC RESONANCE CARDIOPULMONARY EXERCISE TESTING (CMR-CPET)

Author

Al-Kindi, Sadeer G., primary, Thomas, Rahul, additional, Alaiti, Amer, additional, Ravaee, Ben, additional, Jenkins, Trevor, additional, Sawicki, Steven, additional, Seiberlich, Nicole, additional, Lo, Wei-Ching, additional, Watson, Evelyn, additional, Longenecker, Christopher, additional, McComsey, Grace, additional, Hoit, Brian, additional, Simonetti, Orlando, additional, and Rajagopalan, Sanjay, additional

Published
2018
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22. Pharmacologic Targeting of Red Blood Cells to Improve Tissue Oxygenation

Author

Reynolds, James D., primary, Jenkins, Trevor, additional, Matto, Faisal, additional, Nazemian, Ryan, additional, Farhan, Obada, additional, Morris, Nathan, additional, Longphre, John M., additional, Hess, Douglas T., additional, Moon, Richard E., additional, Piantadosi, Claude A., additional, and Stamler, Jonathan S., additional

Published
2018
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30. Platelet and MonocyteActivationAfter Transcatheter Aortic Valve Replacement (POTENT-TAVR): A Mechanistic Randomized Trial of Ticagrelor versus Clopidogrel

Author

Zidar, David A., Al-Kindi, Sadeer, Longenecker, Chris T., Parikh, Sahil A., Gillombardo, Carl B., Funderburg, Nicholas T., Juchnowski, Steven, Huntington, Lauren, Jenkins, Trevor, Nmai, Christopher, Osnard, Michael, Shishebhor, Mehdi, Filby, Steven, Tatsuoka, Curtis, Lederman, Michael M., Blackstone, Eugene, Attizzani, Guilherme, and Simon, Daniel I.

Abstract

Inflammation and thrombosis are often linked mechanistically and are associated with adverse events after TAVR. High residual platelet reactivity (HRPR) is especially common when clopidogrel is used in this setting, but its relevance to immune activation is unknown. We sought to determine whether residual P2Y12 activity promotes pro-thrombotic immune activation in the setting of transcatheter aortic valve replacement (TAVR).

Published
2023
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32. THE MAIL.

Author

Burton-Williams, Desmond, Jenkins, Trevor, Ribeiro, Octavio, Parkes, Bradley, de Zoete, Johan, Noga, Greg, Pearcy, Margaret, Kilpatrick, Garin, Lammers, Henry, Boulet, J.G., Cadogan, David, Tyre, Brett, Lawrence, Evelyn, Grant, Andrea, Weatherill, Richard, and Temple, George

Subjects
*LETTERS to the editor, *GAS prices, CANADIAN prime ministers
Abstract

Presents letters to the editor. Criticism of the John Geddes May 9 cover article on the Conservative leader, "Meet the real Stephen Harper"; Readers' responses to the April 25 cover article "The incredible sinking Prime Minister" with comments about the Liberal Party in Canada; Remarks about honoring veterans, in regard to articles about VE-Day in the May 9 issue; Suggestion that rising gasoline prices are a good thing.

Published
2005

33. Abstract 10390: Cardiorespiratory Fitness is Associated With Inflammation and Physical Activity in IV Adults With HIV.

Author

Webel, Allison R, Jenkins, Trevor, Vest, Marianne, Longenecker, Chris, Currie, Jackson, Lu, Jintao, Sattar, Abdus, and Josephson, Richad

Subjects
*PHYSICAL activity, *DYNAMOMETER, *ANAEROBIC threshold, *GENERALIZED estimating equations, *HIV, *PSYCHOLOGICAL stress testing
Abstract

Background: People living with HIV (PLHIV) are at increased risk for cardiovascular disease (CVD). Maximal cardiorespiratory fitness (CRF) is a better predictor of CVD-related mortality than established risk factors. Yet very little is known about CRF in PLHIV and even less is known about how to improve CRF in PLHIV in real world settings. Objective: To examine the effect of a lifestyle exercise and diet intervention in PLHIV, and to examine predictors of change in CRF over six months. Methods: One-hundred and six virally suppressed PLHIV, were randomized to either the intervention (six, standardized group sessions focusing on improving lifestyle behaviors) or the control condition (general diet and exercise advice). All participants completed a maximal cardiorespiratory stress test on a cycle ergometer to determine VO2 peak, VE/VCO2, and VO2 at anaerobic threshold at baseline and six months later. Participants also wore an ActiGraph accelerometer to measure physical activity, completed hip-waist circumference measures, and had a fasting lipid profile, interleukin-6, and hsCRP. Generalized estimating equations were used to examine the effect of the intervention on CRF and predictors of change in CRF. Results: Participants were approximately 53 years old, 65% male (n =70), 86% African American (n =93) and had a current CD4+ T cell count of 671 cells/μL. There was no effect of the intervention on markers of CRF over time (p>0.05). After controlling for age, gender, waist-hip-ratio, a change in IL-6 was inversely associated with change in both VO2peak (p =0.03) and VO2 at anaerobic threshold (p =0.03) (Table 1). Additionally, controlling for age, gender, and waist-hip-ratio, steps taken per day were associated with higher VO2 peak. Over the duration of the 6-month study, participants who engaged in the recommended 10,000 steps per day had a 2.69 ml/kg/min higher VO2 peak (p =0.02). Conclusions: Despite HIV viral suppression, markers of inflammation were associated with a clinically adverse CRF profile in this older HIV+ cohort. However, increased physical activity was associated with improved CRF. Future research understanding how IL-6 might inform treatment goals and improving physical activity in PLHIV is warranted. [ABSTRACT FROM AUTHOR]

Published
2018

34. Readers' Tips.

Author

Billings, Alfie, Gardner, Darren, Jenkins, Trevor, and Wilson, Ben

Subjects
COMPUTERS, COMPUTER periodicals, COMPUTER software, COMPUTER users, ONLINE shopping
Abstract

The article offers tips related to computers from the readers of the journal "Computer Active" including Alfie Billings, Darren Gardner, and Trevor Jenkins. Topics discussed include the Snip Editor computer program from technology company Microsoft, using the Outlook 2013 program for Office 2013 and 365 computer users, and the Tab Snooze Chrome extension for online shopping and paying bill.

Published
2015

35. Arthur G. Steinberg, 1912-2006.

Author

Jenkins T

Subjects
History, 20th Century, United States, Genetics history, Immunoglobulins history
Published
2007

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