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There are limited available data assessing the efficacy of acute energy drink consumption on cognition and gaming performance, nor on cardiovascular safety. To examine the efficacy of acute consumption of a novel energy drink (C4S) versus placebo for improving cognitive and gaming performance and mood. Secondarily, we examined the cardiovascular safety profile of acute C4S consumption. Forty-five healthy, young adult video gamers completed two experimental visits in randomized order where they consumed either C4S or a placebo and then completed a validated battery of neurocognitive tests, played five video games, and completed a mood state survey. Blood pressure (BP), heart rate (HR), oxygen saturation, and electrocardiogram measurements were taken at baseline and repeated throughout each visit. Acute consumption of C4S improved cognitive flexibility (absolute mean or median difference [95% CI] = +4.3 [2.2–6.4]; p < 0.001; d = 0.63), executive function (+4.3 [2.3–6.3]; p < 0.001; d = 0.63), sustained attention (+2.1 [0.6–3.6]; p = 0.01; d = 0.44), motor speed (+2.9 [0.8–4.9]; p < 0.001; d = 0.44), psychomotor speed (+3.9 [0.1–7.7]; p = 0.04; d = 0.32) working memory (+1.0 [0.1–1.9]; p = 0.02; d = 0.35), and performance in the two-dimensional visuospatial game Tetris (+463 [-419–2,065] pts; p = 0.049; d = 0.30) compared to placebo. C4S also improved Fatigue-Inertia (-1 [-3–0]; p = 0.004; d = 0.45), Vigor-Activity (+2.4 [1.3–3.6]; p < 0.001; d = 0.64), Friendliness (+0 [0–1]; p = 0.04; d = 0.32), and Total Mood Disturbance (-3 [-6–0]; p = 0.002; d = 0.44). BP increased slightly in C4S versus placebo, while HR decreased from baseline to post-drink in the C4S condition. Rate-pressure-product was higher in C4S versus placebo independent of time but did not increase from baseline. There was no effect on corrected QT interval. Acute consumption of C4S was efficacious for cognitive performance, visuospatial gaming performance, and mood enhancement, and had no effect on myocardial oxygen demand or ventricular repolarization, despite being associated with increases in BP. [ABSTRACT FROM AUTHOR]

Elevated postprandial triglycerides are an independent cardiovascular disease risk factor and observed in older adults. However, differences in postprandial triglycerides across the spectrum of adulthood remain unclear. We performed a secondary analysis of six studies where adults (aged 18–84 years; N = 155) completed an abbreviated fat tolerance test (9 kcal/kg; 70% fat). Differences in postprandial triglycerides were compared in those ≥50 and <50 years and by decade of life, adjusting for sex and BMI. Compared to those <50 years, participants ≥50 years had higher fasting, 4 h, and Δ triglycerides from baseline (p 's < 0.05). When examining triglyceride parameters by decade, no differences were observed for fasting triglycerides, but 50 s, 60 s, and 70s–80 s displayed greater 4 h and Δ triglycerides versus 20 s (p 's ≤ 0.001). The frequency of adverse postprandial triglyceride responses (i.e., ≥220 mg/dL) was higher in participants ≥50 versus <50 years (p < 0.01), and in 60 s compared to all other decades (p = 0.01). Older age was generally associated with higher postprandial triglycerides, with no divergence across the spectrum of older adulthood. In our sample, postprandial triglyceride differences in older and younger adults were driven by those >50 years relative to young adults in their 20 s. N/A (secondary analysis). • Fasting triglycerides were similar across all decades of life. • Yet, 50 s, 60 s, 70/80 s had greater postprandial triglyceride responses versus 20 s. • 60 s had the highest frequency of adverse postprandial responses vs. other decades. [ABSTRACT FROM AUTHOR]

The consumption of a high-fat meal can induce postprandial lipemia and endothelial dysfunction. The authors assessed the impact of age and physical activity on metabolic and vascular outcomes following meal consumption in healthy adults. The authors recruited four groups: younger active (age 22.1 ± 1.4 years; n = 9), younger inactive (age 22.6 ± 3.7 years; n = 8), older active (age 68.4 ± 7.7 years; n = 8), and older inactive (age 67.7 ± 7.2 years; n = 7). The metabolic outcomes were measured at the baseline and hourly for 6 hr post high-fat meal consumption (12 kcal/kg; 63% fat). Flow-mediated dilation was measured at the baseline, 2 hr, and 4 hr postmeal. The total area under the curve for triglycerides was significantly lower in the more active groups, but did not differ based on age (younger active = 6.5 ± 1.4 mmol/L × 6 hr, younger inactive = 11.7 ± 4.8, older active = 6.8 ± 2.7, older inactive = 12.1 ± 1.7; p =.0004). After adjusting for artery diameter, flow-mediated dilation differed between groups at the baseline (younger active = 4.8 ± 1.6%, younger inactive = 2.5 ± 0.5, older active = 3.4 ± 0.9, older inactive = 2.2 ± 0.4; p <.001) and decreased significantly across groups 4 hr postmeal (mean difference = 0.82; 95% CI [0.02, 1.6]; p =.04). These findings highlight the beneficial effect of regular physical activity on postprandial lipemia, independent of age. [ABSTRACT FROM AUTHOR]

Pitch velocity (PV) is important for pitching success, and the pelvis and trunk likely influence pitch performance. The purposes of this study were to examine the differences in pelvis and trunk kinetics and kinematics in professional baseball pitchers who throw at lower versus higher velocities (HVPs) and to examine the relationships among pelvis and trunk kinetics and kinematics and PV during each phase of the pitch delivery. The pitch velocity, pelvis and trunk peak angular velocities, kinetic energies and torques, and elbow and shoulder loads were compared among HVPs (n = 71; PV ≥ 40.2 m/s) and lower velocities pitchers (n = 78; PV < 39.8 m/s), as were trunk and pelvis rotation, flexion, and obliquity among 7 phases of the pitching delivery. Relationships among the kinetic and kinematic variables and PVs were examined. Higher velocity pitchers achieved greater upper trunk rotation at hand separation (+7.2°, P <.001) and elbow extension (+5.81°, P =.002) and were able to generate greater upper trunk angular velocities (+36.6 m/s, P =.01) compared with lower velocity pitcher. Trunk angular velocity (r =.29) and upper trunk rotation at hand separation (r =.18) and foot contact (r =.17) were weakly related to PV. Therefore, HVPs rotate their upper trunk to a greater degree during the early phases of the pitching motion and subsequently generate greater trunk angular velocities and PV. [ABSTRACT FROM AUTHOR]