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28 results on '"Jenjaroen, Kemajittra"'

1. Role of Burkholderia pseudomallei--Specific IgG2 in Adults with Acute Melioidosis, Thailand

Author

Chaichana, Panjaporn, Jenjaroen, Kemajittra, Chumseng, Suchintana, Sumonwiriya, Manutsanun, Rongkard, Patpong, Kronsteiner, Barbara, Teparrukkul, Prapit, Limmathurotsakul, Direk, Day, Nicholas P.J., Chantratita, Narisara, and Dunachie, Susanna J.

Subjects
Antigen-antibody reactions -- Testing, Pseudomonas infections -- Diagnosis -- Care and treatment, Immunoglobulin G -- Identification and classification, Health
Abstract

Melioidosis is a major cause of fatal community-acquired septicemia in highly endemic areas, including northeast Thailand and north Australia (2,2). Melioidosis is now known to be endemic in [greater than [...]

Published
2021
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2. Human Immune Responses to Melioidosis and Cross-Reactivity to Low-Virulence Burkholderia Species, Thailand

Author

Rongkard, Patpong, Kronsteiner, Barbara, Hantrakun, Viriya, Jenjaroen, Kemajittra, Sumonwiriya, Manutsanun, Chaichana, Panjaporn, Chumseng, Suchintana, Chantratita, Narisara, Wuthiekanun, Vanaporn, Fletcher, Helen A., Teparrukkul, Prapit, Limmathurotsakul, Direk, Day, Nicholas P.J., and Dunachie, Susanna J.

Subjects
Pseudomonas infections -- Physiological aspects, Burkholderia -- Health aspects, Host-bacteria relationships, Immune response -- Observations, Environmental toxicology, Virulence (Microbiology), Medical research, Type 2 diabetes, Polysaccharides, Diseases, Health
Abstract

Melioidosis is a neglected tropical disease with an estimated annual global mortality rate of 89,000 (1). Its cause is the gram-negative bacterium Burkholderia pseudomallei, which is found in environmental soil [...]

Published
2020
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4. Antibodies in Melioidosis: The Role of the Indirect Hemagglutination Assay in Evaluating Patients and Exposed Populations

Author

Chaichana, Panjaporn, primary, Jenjaroen, Kemajittra, additional, Amornchai, Premjit, additional, Chumseng, Suchintana, additional, Langla, Sayan, additional, Rongkard, Patpong, additional, Sumonwiriya, Manutsanun, additional, Jeeyapant, Atthanee, additional, Chantratita, Narisara, additional, Teparrukkul, Prapit, additional, Limmathurotsakul, Direk, additional, Day, Nicholas P. J., additional, Wuthiekanun, Vanaporn, additional, and Dunachie, Susanna J., additional

Published
2018
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5. Role of Burkholderia pseudomallei-Specific IgG2 in Adults with Acute Melioidosis, Thailand.

Author

Panjaporn Chaichana, Kemajittra Jenjaroen, Suchintana Chumseng, Manutsanun Sumonwiriya, Patpong Rongkard, Kronsteiner, Barbara, Teparrukkul, Prapit, Limmathurotsakul, Direk, Day, Nicholas P. J., Chantratita, Narisara, Dunachie, Susanna J., Chaichana, Panjaporn, Jenjaroen, Kemajittra, Chumseng, Suchintana, Sumonwiriya, Manutsanun, and Rongkard, Patpong

Subjects
MELIOIDOSIS, BURKHOLDERIA, PHAGOCYTIC function tests, PHAGOCYTOSIS, BURKHOLDERIA pseudomallei, CD14 antigen, LOGISTIC regression analysis, RESEARCH, IMMUNOGLOBULINS, RESEARCH methodology, MEDICAL cooperation, EVALUATION research, COMPARATIVE studies, ENZYME-linked immunosorbent assay, RESEARCH funding
Abstract

Melioidosis is a life-threatening infectious disease caused by the gram-negative bacillus Burkholderia pseudomallei. An effective vaccine is needed, but data on protective immune responses in human melioidosis are lacking. We used ELISA and an antibody-dependent cellular phagocytosis assay to identify the major features of protective antibodies in patients with acute melioidosis in Thailand. We found that high levels of B. pseudomallei-specific IgG2 are associated with protection against death in a multivariable logistic regression analysis adjusting for age, diabetes, renal disease, and neutrophil count. Serum from melioidosis survivors enhanced bacteria uptake into human monocytes expressing FcγRIIa-H/R131, an intermediate-affinity IgG2-receptor, compared with serum from nonsurvivors. We did not find this enhancement when using monocytes carrying the low IgG2-affinity FcγRIIa-R131 allele. The findings indicate the importance of IgG2 in protection against death in human melioidosis, a crucial finding for antibody-based therapeutics and vaccine development. [ABSTRACT FROM AUTHOR]

Published
2021
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6. Human Immune Responses to Melioidosis and Cross-Reactivity to Low-Virulence Burkholderia Species, Thailand1.

Author

Rongkard, Patpong, Kronsteiner, Barbara, Hantrakun, Viriya, Jenjaroen, Kemajittra, Sumonwiriya, Manutsanun, Chaichana, Panjaporn, Chumseng, Suchintana, Chantratita, Narisara, Wuthiekanun, Vanaporn, Fletcher, Helen A., Teparrukkul, Prapit, Limmathurotsakul, Direk, Day, Nicholas P. J., and Dunachie, Susanna J.

Subjects
MELIOIDOSIS, BURKHOLDERIA, IMMUNE response, BURKHOLDERIA pseudomallei, TROPICAL medicine, IMMUNITY in fish, HUMORAL immunity, CELLULAR immunity
Abstract

Melioidosis is a neglected tropical disease with an estimated annual mortality rate of 89,000 in 45 countries across tropical regions. The causative agent is Burkholderia pseudomallei, a gram-negative soil-dwelling bacterium. In Thailand, B. pseudomallei can be found across multiple regions, along with the low-virulence B. thailandensis and the recently discovered B. thailandensis variant (BTCV), which expresses B. pseudomallei-like capsular polysaccharide. Comprehensive studies of human immune responses to B. thailandensis variants and cross-reactivity to B. pseudomallei are not complete. We evaluated human immune responses to B. pseudomallei, B. thailandensis, and BTCV in melioidosis patients and healthy persons in B. pseudomallei-endemic areas using a range of humoral and cellular immune assays. We found immune cross-reactivity to be strong for both humoral and cellular immunity among B. pseudomallei, B. thailandensis, and BTCV. Our findings suggest that environmental exposure to low-virulence strains may build cellular immunity to B. pseudomallei. [ABSTRACT FROM AUTHOR]

Published
2020
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7. Immune response to recombinant Burkholderia pseudomallei FliC

Author

Koosakulnirand, Sirikamon, primary, Phokrai, Phornpun, additional, Jenjaroen, Kemajittra, additional, Roberts, Rosemary A., additional, Utaisincharoen, Pongsak, additional, Dunachie, Susanna J., additional, Brett, Paul J., additional, Burtnick, Mary N., additional, and Chantratita, Narisara, additional

Published
2018
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8. Characterization of the rhesus macaque (Macaca mulatta) scrub typhus model: Susceptibility to intradermal challenge with the human pathogen Orientia tsutsugamushi Karp

Author

Sunyakumthorn, Piyanate, primary, Somponpun, Suwit J., additional, Im-erbsin, Rawiwan, additional, Anantatat, Tippawan, additional, Jenjaroen, Kemajittra, additional, Dunachie, Susanna J., additional, Lombardini, Eric D., additional, Burke, Robin L., additional, Blacksell, Stuart D., additional, Jones, James W., additional, Mason, Carl J., additional, Richards, Allen L., additional, Day, Nicholas P. J., additional, and Paris, Daniel H., additional

Published
2018
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9. Infection with Burkholderia pseudomallei – immune correlates of survival in acute melioidosis

Author

Dunachie, Susanna J., primary, Jenjaroen, Kemajittra, additional, Reynolds, Catherine J., additional, Quigley, Kathryn J., additional, Sergeant, Ruhena, additional, Sumonwiriya, Manutsanun, additional, Chaichana, Panjaporn, additional, Chumseng, Suchintana, additional, Ariyaprasert, Pitchayanant, additional, Lassaux, Patricia, additional, Gourlay, Louise, additional, Promwong, Charuporn, additional, Teparrukkul, Prapit, additional, Limmathurotsakul, Direk, additional, Day, Nicholas P. J., additional, Altmann, Daniel M., additional, and Boyton, Rosemary J., additional

Published
2017
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10. Strong interferon-gamma mediated cellular immunity to scrub typhus demonstrated using a novel whole cell antigen ELISpot assay in rhesus macaques and humans

Author

Sumonwiriya, Manutsanun, primary, Paris, Daniel H., additional, Sunyakumthorn, Piyanate, additional, Anantatat, Tippawan, additional, Jenjaroen, Kemajittra, additional, Chumseng, Suchintana, additional, Im-erbsin, Rawiwan, additional, Tanganuchitcharnchai, Ampai, additional, Jintaworn, Suthatip, additional, Blacksell, Stuart D., additional, Chowdhury, Fazle R., additional, Kronsteiner, Barbara, additional, Teparrukkul, Prapit, additional, Burke, Robin L., additional, Lombardini, Eric D., additional, Richards, Allen L., additional, Mason, Carl J., additional, Jones, James W., additional, Day, Nicholas P. J., additional, and Dunachie, Susanna J., additional

Published
2017
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11. A nonsense mutation in TLR5 is associated with survival and reduced IL-10 and TNF-α levels in human melioidosis

Author

Chaichana, Panjaporn, primary, Chantratita, Narisara, additional, Brod, Florian, additional, Koosakulnirand, Sirikamon, additional, Jenjaroen, Kemajittra, additional, Chumseng, Suchintana, additional, Sumonwiriya, Manutsanun, additional, Burtnick, Mary N., additional, Brett, Paul J., additional, Teparrukkul, Prapit, additional, Limmathurotsakul, Direk, additional, Day, Nicholas P. J., additional, Dunachie, Susanna J., additional, and West, T. Eoin, additional

Published
2017
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14. T-Cell Responses Are Associated with Survival in Acute Melioidosis Patients

Author

Jenjaroen, Kemajittra, primary, Chumseng, Suchintana, additional, Sumonwiriya, Manutsanun, additional, Ariyaprasert, Pitchayanant, additional, Chantratita, Narisara, additional, Sunyakumthorn, Piyanate, additional, Hongsuwan, Maliwan, additional, Wuthiekanun, Vanaporn, additional, Fletcher, Helen A., additional, Teparrukkul, Prapit, additional, Limmathurotsakul, Direk, additional, Day, Nicholas P. J., additional, and Dunachie, Susanna J., additional

Published
2015
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15. T Cell Immunity to the Alkyl Hydroperoxide Reductase of Burkholderia pseudomallei: A Correlate of Disease Outcome in Acute Melioidosis

Author

Reynolds, Catherine, primary, Goudet, Amélie, additional, Jenjaroen, Kemajittra, additional, Sumonwiriya, Manutsanun, additional, Rinchai, Darawan, additional, Musson, Julie, additional, Overbeek, Saskia, additional, Makinde, Julia, additional, Quigley, Kathryn, additional, Manji, Jiten, additional, Spink, Natasha, additional, Yos, Pagnarith, additional, Wuthiekanun, Vanaporn, additional, Bancroft, Gregory, additional, Robinson, John, additional, Lertmemongkolchai, Ganjana, additional, Dunachie, Susanna, additional, Maillere, Bernard, additional, Holden, Matthew, additional, Altmann, Daniel, additional, and Boyton, Rosemary, additional

Published
2015
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16. Accuracy of AccessBio Immunoglobulin M and Total Antibody Rapid Immunochromatographic Assays for the Diagnosis of Acute Scrub Typhus Infection

Author

NAVAL MEDICAL RESEARCH CENTER SILVER SPRING MD RICKETTSIAL DISEASES DEPT, Blacksell, Stuart D, Jenjaroen, Kemajittra, Phetsouvanh, Rattanaphone, Wuthiekanun, Vanaporn, Day, Nicholas P, Newton, Paul N, Ching, Wei-Mei, NAVAL MEDICAL RESEARCH CENTER SILVER SPRING MD RICKETTSIAL DISEASES DEPT, Blacksell, Stuart D, Jenjaroen, Kemajittra, Phetsouvanh, Rattanaphone, Wuthiekanun, Vanaporn, Day, Nicholas P, Newton, Paul N, and Ching, Wei-Mei

Abstract

Using archived samples, we assessed the diagnostic capacity of a rapid immunochromatographic test (ICT) for the detection of Orientia tsutsugamushi IgM and total antibodies to aid with the diagnosis of acute scrub typhus infection in febrile patients in Laos. The sensitivity and the specificity of the ICT for the detection of lgM were 96.8% (121/125 samples; 95% confidence interval [CI], 92.1 to 99.1%) and 93.3% (98/105 samples; 95% CI, 86.7 to 97.3%), respectively. For the detection of total antibodies, the sensitivity was 97.6% (122/125 samples; 95% CI, 93.1 to 99.5%), but the specificity was much lower, at 71.4% (75/105 samples; 95% CI, 61.8 to 79.8%)., Pub in Clinical and Vaccine Immunology, v17 n2 p263-266, Feb 2010.

Published
2010

17. Orientia tsutsugamushi in Human Scrub Typhus Eschars Shows Tropism for Dendritic Cells and Monocytes Rather than Endothelium

Author

Paris, Daniel H., primary, Phetsouvanh, Rattanaphone, additional, Tanganuchitcharnchai, Ampai, additional, Jones, Margaret, additional, Jenjaroen, Kemajittra, additional, Vongsouvath, Manivanh, additional, Ferguson, David P. J., additional, Blacksell, Stuart D., additional, Newton, Paul N., additional, Day, Nicholas P. J., additional, and Turner, Gareth D. H., additional

Published
2012
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18. Evaluation of Six Commercial Point-of-Care Tests for Diagnosis of Acute Dengue Infections: the Need for Combining NS1 Antigen and IgM/IgG Antibody Detection To Achieve Acceptable Levels of Accuracy

Author

Blacksell, Stuart D., primary, Jarman, Richard G., additional, Bailey, Mark S., additional, Tanganuchitcharnchai, Ampai, additional, Jenjaroen, Kemajittra, additional, Gibbons, Robert V., additional, Paris, Daniel H., additional, Premaratna, Ranjan, additional, de Silva, H. Janaka, additional, Lalloo, David G., additional, and Day, Nicholas P. J., additional

Published
2011
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21. The infective causes of hepatitis and jaundice amongst hospitalised patients in Vientiane, Laos

Author

Syhavong, Bounkong, primary, Rasachack, Bouachanh, additional, Smythe, Lee, additional, Rolain, Jean-Marc, additional, Roque-Afonso, Anne-Marie, additional, Jenjaroen, Kemajittra, additional, Soukkhaserm, Vimone, additional, Phongmany, Simmaly, additional, Phetsouvanh, Rattanaphone, additional, Soukkhaserm, Sune, additional, Thammavong, Te, additional, Mayxay, Mayfong, additional, Blacksell, Stuart D., additional, Barnes, Eleanor, additional, Parola, Philippe, additional, Dussaix, Elisabeth, additional, Raoult, Didier, additional, Humphreys, Isla, additional, Klenerman, Paul, additional, White, Nicholas J., additional, and Newton, Paul N., additional

Published
2010
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24. Evaluation of the Panbio dengue virus nonstructural 1 antigen detection and immunoglobulin M antibody enzyme-linked immunosorbent assays for the diagnosis of acute dengue infections in Laos

Author

Blacksell, Stuart D., primary, Mammen, Mammen P., additional, Thongpaseuth, Soulignasack, additional, Gibbons, Robert V., additional, Jarman, Richard G., additional, Jenjaroen, Kemajittra, additional, Nisalak, Ananda, additional, Phetsouvanh, Rattanaphone, additional, Newton, Paul N., additional, and Day, Nicholas P.J., additional

Published
2008
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25. Prospective Study To Determine Accuracy of Rapid Serological Assays for Diagnosis of Acute Dengue Virus Infection in Laos

Author

Blacksell, Stuart D., primary, Bell, David, additional, Kelley, James, additional, Mammen, Mammen P., additional, Gibbons, Robert V., additional, Jarman, Richard G., additional, Vaughn, David W., additional, Jenjaroen, Kemajittra, additional, Nisalak, Ananda, additional, Thongpaseuth, Soulignasack, additional, Vongsouvath, Manivanh, additional, Davong, Viengmone, additional, Phouminh, Phonelavanh, additional, Phetsouvanh, Rattanaphone, additional, Day, Nicholas P. J., additional, and Newton, Paul N., additional

Published
2007
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26. Strong interferon-gamma mediated cellular immunity to scrub typhus demonstrated using a novel whole cell antigen ELISpot assay in rhesus macaques and humans

Author

Sumonwiriya, Manutsanun, Paris, Daniel H., Sunyakumthorn, Piyanate, Anantatat, Tippawan, Jenjaroen, Kemajittra, Chumseng, Suchintana, Im-Erbsin, Rawiwan, Tanganuchitcharnchai, Ampai, Jintaworn, Suthatip, Blacksell, Stuart D., Chowdhury, Fazle R., Kronsteiner-Dobramysl, Barbara, Teparrukkul, Prapit, Burke, Robin L., Lombardini, Eric D., Richards, Allen L., Mason, Carl J., Jones, James W., Day, Nicholas P. J., and Dunachie, Susanna J.

Subjects
3. Good health

28. Human Immune Responses to Melioidosis and Cross-Reactivity to Low-Virulence Burkholderia Species, Thailand1.

Author

Rongkard, Patpong, Kronsteiner, Barbara, Hantrakun, Viriya, Jenjaroen, Kemajittra, Sumonwiriya, Manutsanun, Chaichana, Panjaporn, Chumseng, Suchintana, Chantratita, Narisara, Wuthiekanun, Vanaporn, Fletcher, Helen A., Teparrukkul, Prapit, Limmathurotsakul, Direk, Day, Nicholas P. J., and Dunachie, Susanna J.

Subjects
*MELIOIDOSIS, *BURKHOLDERIA, *IMMUNE response, *BURKHOLDERIA pseudomallei, *TROPICAL medicine, *IMMUNITY in fish, *HUMORAL immunity, *CELLULAR immunity
Abstract

Melioidosis is a neglected tropical disease with an estimated annual mortality rate of 89,000 in 45 countries across tropical regions. The causative agent is Burkholderia pseudomallei, a gram-negative soil-dwelling bacterium. In Thailand, B. pseudomallei can be found across multiple regions, along with the low-virulence B. thailandensis and the recently discovered B. thailandensis variant (BTCV), which expresses B. pseudomallei-like capsular polysaccharide. Comprehensive studies of human immune responses to B. thailandensis variants and cross-reactivity to B. pseudomallei are not complete. We evaluated human immune responses to B. pseudomallei, B. thailandensis, and BTCV in melioidosis patients and healthy persons in B. pseudomallei-endemic areas using a range of humoral and cellular immune assays. We found immune cross-reactivity to be strong for both humoral and cellular immunity among B. pseudomallei, B. thailandensis, and BTCV. Our findings suggest that environmental exposure to low-virulence strains may build cellular immunity to B. pseudomallei. [ABSTRACT FROM AUTHOR]

Published
2020
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