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3 results on '"Jenelle McAllister"'

1. Serum and synovial fluid cytokine profiling in hip osteoarthritis: distinct from knee osteoarthritis and correlated with pain

Author

Guomin Ren, Ian Lutz, Pamela Railton, J. Preston Wiley, Jenelle McAllister, James Powell, and Roman J. Krawetz

Subjects
Osteoarthritis, Inflammation, Pain, Hip, Diseases of the musculoskeletal system, RC925-935
Abstract

Abstract Background Inflammation is associated with the onset and progression of osteoarthritis in multiple joints. It is well known that mechanical properties differ between different joints, however, it remains unknown if the inflammatory process is similar/distinct in patients with hip vs. knee OA. Without complete understanding of the role of any specific cytokine in the inflammatory process, understanding the ‘profile’ of inflammation in a given patient population is an essential starting point. The aim of this study was to identify serum cytokine profiles in hip Osteoarthritis (OA), and investigate the association between cytokine concentrations and clinical measurements within this patient population and compare these findings to knee OA and healthy control cohorts. Methods In total, 250 serum samples (100 knee OA, 50 hip OA and 100 control) and 37 synovial fluid samples (8 knee OA, 14 hip OA and 15 control) were analyzed using a multiplex ELISA based approach. Synovial biopsies were also obtained and examined for specific cytokines. Pain, physical function and activity within the hip OA cohort were examined using the HOOS, SF-36, HHS and UCLA outcome measures. Results The three cohorts showed distinct serum cytokine profiles. EGF, FGF2, MCP3, MIP1α, and IL8 were differentially expressed between hip and knee OA cohorts; while FGF2, GRO, IL8, MCP1, and VEGF were differentially expressed between hip OA and control cohorts. Eotaxin, GRO, MCP1, MIP1β, VEGF were differentially expressed between knee OA and control cohorts. EGF, IL8, MCP1, MIP1β were differentially expressed in synovial fluid from a sub-set of patients from each cohort. Specifically within the hip OA cohort, IL-6, MDC and IP10 were associated with pain and were also found to be present in synovial fluid and synovial membrane (except IL-6) of patients with hip OA. Conclusion OA may include different inflammatory subtypes according to affected joints and distinct inflammatory processes may drive OA in these joints. IL6, MDC and IP10 are associated with hip OA pain and these proteins may be able to provide additional information regarding pain in hip OA patients.

Published
2018
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2. Impact of Decoding Work within a Professional Program

Author

Jenelle McAllister, Breda Eubank, Khatija Westbrook, Mark R. Lafave, Michelle Yeo, and Dennis Valdez

Subjects
020205 medical informatics, Higher education, business.industry, 05 social sciences, Professional development, 050301 education, 02 engineering and technology, Education, Community of practice, Work (electrical), Concept learning, 0202 electrical engineering, electronic engineering, information engineering, Mathematics education, Curriculum development, Scholarship of Teaching and Learning, business, Psychology, 0503 education, Decoding methods
Published
2017
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3. Content Validation of Athletic Therapy Clinical Presentations in Canada

Author

Breda Eubank, Mark R. Lafave, Dennis Valdez, Michelle Yeo, Jenelle McAllister, and Khatija Westbrook

Subjects
Content validation, Medical education, 020205 medical informatics, business.industry, Teaching method, College athletics, Context (language use), 030229 sport sciences, 02 engineering and technology, General Medicine, 03 medical and health sciences, Athletic training, 0302 clinical medicine, Pedagogy, 0202 electrical engineering, electronic engineering, information engineering, Content validity, Medicine, business
Abstract

Context: Competency-based education requires strong planning and a vehicle to deliver and track students' progress across their undergraduate programs. Clinical presentations (CPs) are proposed as 1 method to deliver a competency-based curriculum in a Canadian undergraduate athletic therapy program.Objective: Validation of 253 CPs.Setting: Canadian universities/colleges and clinical practices.Patients or Other Participants: Six Canadian Athletic Therapists Association-accredited program directors and 6 athletic therapists with at least 10 years of experience working in both field and clinical athletic therapy settings.Intervention(s): We surveyed 12 experts who rated the importance and difficulty of 253 CPs using a 100-mm and electronic visual analog scale with extremely important at 1 anchor and irrelevant at the other end. Difficulty was measured in a similar manner anchored by extremely difficulty and extremely easy.Main Outcome Measure(s): Descriptive statistics for importance and difficulty were tabulated on all CPs. An importance-difficulty index was calculated as a mean score of both importance and difficulty scores.Results: Data were converted into quartiles to represent a 4-point categorical importance scale to mimic the original categories from the Ebel procedure (ie, essential, important, acceptable, and questionable). Difficulty was likewise converted into quartiles representing a 4-point categorical difficulty scale. Mean importance scores ranged from 99.3 for airway management (ie, most important) to 54 for high altitude cerebral edema (ie, less important). Clinical presentation difficulty scales ranged from 89.8 for biceps contusion (ie, easier) to 21.2 for decompression illness (ie, harder).Conclusions: These 253 CPs are thought to be representative (ie, valid) of the athletic therapy scope of practice in Canada. To our knowledge, CPs have not been developed in the athletic therapy context prior to this research. We anticipate more will be identified as these CPs are used to align teaching, learning, and assessment within competency-based athletic therapy programs in Canada.

Published
2016
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