1. Association between CTLA-4 gene promoter (49 A/G) in exon 1 polymorphisms and inflammatory bowel disease in the Tunisian population
- Author
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Alaya Walid, Sfar Imen, Aouadi Houda, Jendoubi Saloua, Najjar Tawfik, Filali Azza, Gorgi Yousr, Abdallah Taieb, Mouelhi Leila, Matri Samira, and Ayed Khaled
- Subjects
Crohn′s disease ,CTLA-4 ,gene polymorphism ,inflammatory bowel disease ,ulcerative colitis ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background/Aim: To investigate the possible association between the polymorphism of the CTLA-4 exon 1 +49 A/G and susceptibility to Crohn′s disease (CD) and ulcerative colitis (UC) in the Tunisian population. Methods: The +49 A/G dimorphism was analyzed in 119 patients with CD, 65 patients with UC, and 100 controls by the polymerase chain reaction-restriction fragment length polymorphism method. Results: Significantly higher frequencies of the CTLA-4 +49A allele and A/A homozygous individuals were observed in patients with CD when compared with controls (pc = 0.0023 and pc = 0.0003, respectively). Analysis of CTLA-4 A/G polymorphism with respect to sex in CD showed a significant difference in A/A genotypes between female patients and controls (pc = 0.0001 and pc = 0.038, respectively). There were no differences in the subgroups of patients with CD. Conclusions: Forty-nine A alleles and AA genotype are associated with CD susceptibility in Tunisians. Other genes involved in the T-cell regulation remain strong candidates for IBD susceptibility and require further investigation.
- Published
- 2009