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5. HYPE: Predicting Blood Pressure from Photoplethysmograms in a Hypertensive Population

Author

Morassi Sasso, Ariane, Datta, Suparno, Jeitler, Michael, Steckhan, Nico, Kessler, Christian S., Michalsen, Andreas, Arnrich, Bert, Böttinger, Erwin, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Michalowski, Martin, editor, and Moskovitch, Robert, editor

Published
2020
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9. Wellness or medicine? Use and perception of Ayurveda in Germany: data from an online-representative cross-sectional study

Author

Schiele, Julia Katharina, Jeitler, Michael, Michalsen, Andreas, Stapelfeldt, Elmar, Ortiz, Miriam, Sigl, Mike, Brinkhaus, Benno, Wischnewsky, Manfred, Kessler, Christian S., Schiele, Julia Katharina, Jeitler, Michael, Michalsen, Andreas, Stapelfeldt, Elmar, Ortiz, Miriam, Sigl, Mike, Brinkhaus, Benno, Wischnewsky, Manfred, and Kessler, Christian S.

Abstract

Introduction: Ayurveda, South Asia’s largest and most relevant system of Traditional Medicine, holds a legal status akin to conventional Western medicine in India and elsewhere. There is an almost complete lack of data on the use of Ayurveda in Germany. The aim of this study was to investigate Ayurveda’s utilization patterns, entry points, and factors influencing its use and the perception of Ayurveda among the German population. Methods: Basis of this manuscript was an online-representative survey which involved 4,065 participants aged 18–75 about the use and acceptance of Traditional, Complementary and Integrative Medicine (TCIM) in Germany. The survey was conducted online using Computer Assisted Web Interview (CAWI) in 2022. The dataset was analyzed descriptively and inferentially. Results: Altogether 9.3% (n = 377) of all survey participants (n = 4,065) had already used Ayurveda somehow, either more often (1.7%) or at least once in a lifetime (7.6%). Responders associated Ayurveda primarily with Indian Medicine (27.7%) and wellness (18%). Commonly used Ayurvedic services included non-medical treatments at wellness resorts/spas (48.3%), in outpatient practices (27.1%), and hotels (23.6%). 30.2% of the participants believe in Ayurveda’s therapeutic potential. 76.7% of Ayurveda users find healthy nutrition important or very important. Nine predictors were found to classify Ayurveda users vs. non-users with spirituality and belief in Ayurveda’s therapeutic efficacy as the most relevant ones. Ayurveda seems to be primarily used by well-educated and female individuals, often from higher-income groups and with a rather modern social milieu-orientation. Conclusion: Study results suggest that about every tenth German citizen has used Ayurveda in the past and about one third believes in its therapeutic potential. Because Ayurvedic therapies are often not evidence-based, there is an urgent need to perform high quality randomized controlled trials to investigate potential e, Peer Reviewed

Published
2024

10. Use and acceptance of traditional, complementary and integrative medicine in Germany—an online representative cross-sectional study

Author

Jeitler, Michael, Ortiz, Miriam, Brinkhaus, Benno, Sigl, Mike, Hoffmann, Rasmus, Trübner, Miriam, Michalsen, Andreas, Wischnewsky, Manfred, Kessler, Christian, Jeitler, Michael, Ortiz, Miriam, Brinkhaus, Benno, Sigl, Mike, Hoffmann, Rasmus, Trübner, Miriam, Michalsen, Andreas, Wischnewsky, Manfred, and Kessler, Christian

Abstract

Background: Older representative surveys show that Traditional, Complementary and Integrative Medicine (TCIM) is used by about 60% of the German population. However, no data exists for the current nationwide situation. The main aim of this cross-sectional study is to investigate the current use and acceptance of TCIM in Germany. Methods: This study is based on a representative sample of the German population aged 18–75 years. Participants were asked about the use and acceptance of TCIM. The survey was conducted online using Computer Assisted Web Interview (CAWI) in 2022 by three renowned German market research institutes on behalf of and in close coordination with the working group. The data set was analyzed descriptively and inferentially. Results: In total, 4,065 participants (52% female, 48% male, 0.4% diverse) responded completely (response rate: 21.5%). Among participants, 70% stated that they had used TCIM at some point in their lives, with 32% doing so in the last 12 months and 18% currently. The most common reason given (17%) was musculoskeletal pain. For their own health, 39% stated that TCIM is important. Traditional European Medicine was rated as very/mainly effective by 27% of participants and as partly effective by 44% (conventional medicine: 69% very/mainly effective, 19% partly effective). As a complementary treatment strategy to conventional medicine, 35% considered TCIM to be optimal (“Complementary Medicine”), 33% in combination with conventional medicine (“Integrative Medicine”) and 5% without conventional medicine (“Alternative Medicine”). The majority of the participants were in favor of more research on TCIM and stated that the costs of TCIM services should be covered by health insurance companies (71% and 69%, respectively). Conclusion: These results from a representative online-population suggest that the use of TCIM in Germany remains at a high level. The nationwide relevance of TCIM should be given greater consideration in German health car, Peer Reviewed

Published
2024

16. Meditation-Based Lifestyle Modification in Mild-to-Moderate Depression: Outcomes and Moderation Effects of Spirituality.

Author

Bringmann, Holger C., Berghöfer, Anne, Jeitler, Michael, Michalsen, Andreas, Brunnhuber, Stefan, and Haller, Heidemarie

Subjects
DIAGNOSIS of mental depression, LIFESTYLES, PSYCHOPHYSIOLOGY, REPEATED measures design, RESEARCH funding, SECONDARY analysis, ACADEMIC medical centers, DATA analysis, T-test (Statistics), MINDFULNESS, MENTAL illness, STATISTICAL sampling, QUESTIONNAIRES, SEVERITY of illness index, TREATMENT effectiveness, RANDOMIZED controlled trials, ANALYSIS of covariance, PSYCHOLOGICAL adaptation, ETHICS, YOGA, MEDITATION, SPIRITUALITY, RELIGION, PSYCHOLOGICAL stress, ALTERNATIVE medicine, STATISTICS, DATA analysis software, PSYCHOLOGICAL tests, CONFIDENCE intervals, MENTAL depression, NOSOLOGY, REGRESSION analysis, ALGORITHMS, WELL-being
Abstract

Objective: Understanding the relevance of religion or spirituality (R/S) in the treatment of mental disorders is central to clinical and academic psychiatry. In this secondary analysis, associations of R/S with depression were investigated with respect to a new second-generation mindfulness-based intervention, the Meditation-Based Lifestyle Modification (MBLM) program. Methods: Different aspects of spirituality, spiritual coping, and spiritual engagement were assessed in 81 patients with a diagnosis of mild-to-moderate depression. Treatment effects on R/S postscores and predictor and moderation effects of depression severity and stress change-scores were evaluated at 8 weeks (MBLM vs. CONTROL [drug continuation therapy] vs. TAU [inpatient treatment as usual]) and 6 months (TAU+MBLM vs. TAU). Results: At both time points, significant differences between MBLM versus TAU and CONTROL were found in a range of spiritual outcomes, most of them with a medium-to-large effect size and in favor of MBLM. Baseline interest in spirituality (p = 0.001) and baseline spiritual mind–body practice (p = 0.017) were identified as independent predictors of change in depression severity at 6 months. Moreover, moderation analyses found that patients reporting often/regular spiritual mind–body practice at 6 months did not benefit differently from TAU+MBLM versus TAU (p = 0.437) regarding their change in depression severity and stress, while those reporting no/seldom spiritual mind–body practice at 6 months benefited significantly worse from TAU than from TAU+MBLM (p = 0.002). Conclusions: Participation in the MBLM program resulted in significantly greater increases in spirituality in depressed patients than standard therapy. Interest in spirituality and engagement in spiritual mind–body practices at baseline were positive predictors of clinical outcome in both groups. Patients of any group who regularly performed spiritual mind–body practices benefited equally in terms of antidepressant outcomes, underlining the benefit of these practices within a general therapeutic framework. ClinicalTrials.gov Identifier: NCT03652220 [ABSTRACT FROM AUTHOR]

Published
2024
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17. Effects of an Online Meditation Course on Quality of Life and Positive Emotions: A Prospective Observational Study (EXPANSION Study).

Author

Figura, Hannah Maja, Saha, Felix Joyonto, Seibt, Sonja, Haller, Heidemarie, Bringmann, Holger C., Kessler, Christian S., Kugler, Joachim, Cramer, Holger, Michalsen, Andreas, Kandil, Farid I., and Jeitler, Michael

Subjects
PSYCHOLOGICAL resilience, LIFESTYLES, HEALTH self-care, INTEGRATIVE medicine, SUBSTANCE abuse, MENTAL health, SELF-efficacy, HEALTH status indicators, RESEARCH funding, T-test (Statistics), MEDICAL care, POSITIVE psychology, EDUCATIONAL outcomes, SCIENTIFIC observation, QUESTIONNAIRES, SMOKING, MENTAL illness, INTERNET, EMOTIONS, DESCRIPTIVE statistics, CHI-squared test, LONGITUDINAL method, MIND & body therapies, MEDITATION, QUALITY of life, PSYCHOLOGICAL stress, SPIRITUALITY, RELIGION, DATA analysis software, SOCIODEMOGRAPHIC factors, ADULTS
Abstract

Background: Several meditation interventions showed positive effects on physical and mental health. The aim of this study is a first evaluation of the (within-group) effects of a 21-day online meditation course of the "expansion method." Methods: For this exploratory observational study, parameters were assessed at baseline, at 1 month, and at a 3-month follow-up. Exploratory endpoints were health-related quality of life (PROMIS Preference Score), global health (PROMIS) with the subscales physical and mental health, stress perception (Perceived Stress Scale), positive and negative affect regulation (Positive and Negative Affect Schedule), flourishing (Flourishing Scale), self-efficacy (Short Scale for Measuring General Self-Efficacy Beliefs), gratitude and awe (Gratitude and Awe Questionnaire), resilience (Connor-Davidson Resilience Scale), spirituality (Aspects of Spirituality), and mysticism (Mysticism Scale) on validated inventories. In addition, self-constructed questions (NRS) assessed health status, lifestyle, and concept evaluation. Results: Data from 359 participants were included in this study (response rate: 68% at 1 month, 46% at 3 months). The main analysis was based on the complete cases at 1 month (n = 244 participants; 84% female; 51 ± 11 years; 89% German). Medium effect sizes were found for mental health (p < 0.0001; d = 0.6), flourishing (p < 0.0001; d = 0.63), and negative affect (p < 0.0001; d = 0.68) at 1 month. Small effect sizes were obtained for physical health, stress, positive affect, self-efficacy, spirituality, and mysticism at 3 months. In a sensitivity analysis, the strongest effects at 1 month were found in the subgroup that completed per-protocol (n = 140), followed by those with complete data at all time points (n = 159). Effects were lowest in the intention-to-treat analysis (n = 359). The content of the course was positively evaluated by the participants. Conclusions: The online meditation course based on the expansion method had potentially beneficial effects, especially on mental health parameters. Based on the feasibility results, further research using randomized controlled designs is warranted. Clinical Trial Registration: NCT04950543. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Effects of Prolonged Medical Fasting during an Inpatient, Multimodal, Nature-Based Treatment on Pain, Physical Function, and Psychometric Parameters in Patients with Fibromyalgia: An Observational Study.

Author

Koppold, Daniela A., Kandil, Farid I., Müller, Anna, Güttler, Oliver, Steckhan, Nico, Meiss, Sara, Breinlinger, Carolin, Nelle, Esther, Rajput Khokhar, Anika, Jeitler, Michael, Hanslian, Etienne, Fischer, Jan Moritz, Michalsen, Andreas, and Kessler, Christian S.

Abstract

Fibromyalgia syndrome (FMS) is a common chronic pain disorder and often occurs as a concomitant disease in rheumatological diseases. Managing FMS takes a complex approach and often involves various non-pharmacological therapies. Fasting interventions have not been in the focus of research until recently, but preliminary data have shown effects on short- and medium-term pain as well as on physical and psychosomatic outcomes in different chronic pain disorders. This single-arm observational study investigated the effects of prolonged fasting (3–12 days, <600 kcal/d) embedded in a multimodal treatment setting on inpatients with FMS. Patients who were treated at the Department of Internal Medicine and Nature-Based Therapies of the Immanuel Hospital Berlin, Germany, between 02/2018 and 12/2020 answered questionnaires at hospital admission (V0) and discharge (V1), and then again three (V2), six (V3), and 12 (V4) months later. Selected routine blood and anthropometric parameters were also assessed during the inpatient stay. A total of 176 patients with FMS were included in the study. The Fibromyalgia Impact Questionnaire (FIQ) total score dropped by 13.7 ± 13.9 (p < 0.001) by V1, suggesting an improvement in subjective disease impact. Pain (NRS: reduction by 1.1 ± 2.5 in V1, p < 0.001) and quality of life (WHO-5: +4.9 ± 12.3 in V1, p < 0.001) improved, with a sustainable effect across follow-up visits. In contrast, mindfulness (MAAS: +0.3 ± 0.7 in V1, p < 0.001), anxiety (HADS-A: reduction by 2.9 ± 3.5 in V1, p < 0.0001), and depression (HADS-D: reduction by 2.7 ± 3.0 in V1, p < 0.0001) improved during inpatient treatment, without longer-lasting effects thereafter. During the study period, no serious adverse events were reported. The results suggest that patients with FMS can profit from a prolonged therapeutic fasting intervention integrated into a complex multimodal inpatient treatment in terms of quality of life, pain, and disease-specific functional parameters. ClinicalTrials.gov Identifier: NCT03785197. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Patients’ perspectives on prescription cannabinoid therapies: a cross-sectional, exploratory, anonymous, one-time web-based survey among German patients

Author

Fischer, Jan Moritz, primary, Kandil, Farid I., additional, Katsarova, Ekaterina, additional, Zager, Laura Sophie, additional, Jeitler, Michael, additional, Kugler, Felix, additional, Fitzner, Franziska, additional, Murthy, Vijayendra, additional, Hanslian, Etienne, additional, Wendelmuth, Christoph, additional, Michalsen, Andreas, additional, Karst, Matthias, additional, and Kessler, Christian S., additional

Published
2023
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22. Effects of an Online Meditation Course on Quality of Life and Positive Emotions: A Prospective Observational Study (EXPANSION Study)

Author

Figura, Hannah Maja, primary, Saha, Felix Joyonto, additional, Seibt, Sonja, additional, Haller, Heidemarie, additional, Bringmann, Holger C., additional, Kessler, Christian S., additional, Kugler, Joachim, additional, Cramer, Holger, additional, Michalsen, Andreas, additional, Kandil, Farid I., additional, and Jeitler, Michael, additional

Published
2023
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26. Effects of an Integrative Day Care Clinic Program with a Focus on Nature Therapy in a Hospital Park Setting on Quality of Life in Oncological Patients—A Non-Randomized Controlled Study

Author

Kuballa, Lisa, primary, Kessler, Christian S., additional, Kandil, Farid I., additional, von Scheidt, Christel, additional, Meinköhn, Meline, additional, Koch, Barbara, additional, Wischnewsky, Manfred, additional, Michalsen, Andreas, additional, and Jeitler, Michael, additional

Published
2023
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29. Correction to: HYPE: Predicting Blood Pressure from Photoplethysmograms in a Hypertensive Population

Author

Morassi Sasso, Ariane, Datta, Suparno, Jeitler, Michael, Steckhan, Nico, Kessler, Christian S., Michalsen, Andreas, Arnrich, Bert, Böttinger, Erwin, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Michalowski, Martin, editor, and Moskovitch, Robert, editor

Published
2020
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30. Effects of Prolonged Fasting during Inpatient Multimodal Treatment on Pain and Functional Parameters in Knee and Hip Osteoarthritis: A Prospective Exploratory Observational Study

Author

Koppold, Daniela A., primary, Kandil, Farid I., additional, Güttler, Oliver, additional, Müller, Anna, additional, Steckhan, Nico, additional, Meiß, Sara, additional, Breinlinger, Carolin, additional, Nelle, Esther, additional, Hartmann, Anika M., additional, Jeitler, Michael, additional, Hanslian, Etienne, additional, Fischer, Jan Moritz, additional, Michalsen, Andreas, additional, and Kessler, Christian S., additional

Published
2023
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31. Effects of Prolonged Fasting During Inpatient Multimodal Treatment on Pain and Functional Parameters in Knee and Hip Osteoarthritis: A Prospective Exploratory Observational Study

Author

Koppold, Daniela Artemis, primary, Kandil, Farid I., additional, Güttler, Oliver, additional, Müller, Anna, additional, Steckhan, Nico, additional, Meiß, Sara, additional, Breinlinger, Carolin, additional, Nelle, Esther, additional, Hartmann, Anika M., additional, Jeitler, Michael, additional, Hanslian, Etienne, additional, Fischer, Jan Moritz, additional, Michalsen, Andreas, additional, and Kessler, Christian S., additional

Published
2023
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35. Self-care and lifestyle interventions of complementary and integrative medicine during the COVID-19 pandemic—A cross-sectional study

Author

Jeitler, Michael, primary, Erehman, Avital, additional, Koppold, Daniela A., additional, Ortiz, Miriam, additional, Jerzynski, Lea, additional, Stöckigt, Barbara, additional, Rotter, Gabriele, additional, Blakeslee, Sarah, additional, Brinkhaus, Benno, additional, Michalsen, Andreas, additional, Seifert, Georg, additional, Cramer, Holger, additional, Kandil, Farid I., additional, and Kessler, Christian S., additional

Published
2023
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37. Knowledge, Attitudes and Application of Critical Nutrient Supplementation in Vegan Diets among Healthcare Professionals—Survey Results from a Medical Congress on Plant-Based Nutrition

Author

Jeitler, Michael, primary, Storz, Maximilian Andreas, additional, Steckhan, Nico, additional, Matthiae, Dorothea, additional, Dressler, Justina, additional, Hanslian, Etienne, additional, Koppold, Daniela A., additional, Kandil, Farid I., additional, Michalsen, Andreas, additional, and Kessler, Christian S., additional

Published
2022
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39. To eat or not to eat—an exploratory randomized controlled trial on fasting and plant-based diet in rheumatoid arthritis (NutriFast-Study)

Author

Hartmann, Anika M., primary, Dell'Oro, Melanie, additional, Spoo, Michaela, additional, Fischer, Jan Moritz, additional, Steckhan, Nico, additional, Jeitler, Michael, additional, Häupl, Thomas, additional, Kandil, Farid I., additional, Michalsen, Andreas, additional, Koppold-Liebscher, Daniela A., additional, and Kessler, Christian S., additional

Published
2022
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41. Health-Related Self-Care Strategies and Coping Resources During the COVID-19 Pandemic: An Online-Based Cross-Sectional Study

Author

Jerzynski, Lea, primary, Rotter, Gabriele, additional, Binting, Sylvia, additional, Teut, Michael, additional, Tissen-Diabaté, Tatjana, additional, Jeitler, Michael, additional, Seifert, Georg, additional, Kessler, Christian, additional, Michalsen, Andreas, additional, Cramer, Holger, additional, Stöckigt, Barbara, additional, Brinkhaus, Benno, additional, and Ortiz, Miriam, additional

Published
2022
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42. A Randomized Controlled Trial of Fasting and Lifestyle Modification in Patients with Metabolic Syndrome: Effects on Patient-Reported Outcomes

Author

Jeitler, Michael, Lauche, Romy, Hohmann, Christoph, Choi, Kyung-Eun (Anna), Schneider, Nadia, Steckhan, Nico, Rathjens, Florian, Anheyer, Dennis, Paul, Anna, von Scheidt, Christel, Ostermann, Thomas, Schneider, Elisabeth, Koppold-Liebscher, Daniela, Kessler, Christian S., Dobos, Gustav, Michalsen, Andreas, and Cramer, Holger

Subjects
Male, Metabolic Syndrome, lifestyle, mindfulness, Depression, Medizin, MICOM (Mind-Body Medicine in Integrative and Complementary Medicine), modified DASH diet, Fasting, relaxation, Mediterranean diet, Quality of Life, Humans, Female, Patient Reported Outcome Measures, self-efficacy, Life Style, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
Abstract

CA extern Lifestyle interventions can have a positive impact on quality of life and psychological parameters in patients with metabolic syndrome (MetS). In this randomized controlled trial, 145 participants with MetS (62.8% women; 59.7 +/- 9.3 years) were randomized to (1) 5-day fasting followed by 10 weeks of lifestyle modification (F + LM; modified DASH diet, exercise, mindfulness; n = 73) or (2) 10 weeks of lifestyle modification only (LM; n = 72). Outcomes were assessed at weeks 0, 1, 12, and 24, and included quality of life (Short-Form 36 Health Survey Questionnaire, SF-36), anxiety/depression (Hospital Anxiety and Depression Scale, HADS), stress (Cohen Perceived Stress Scale, CPSS), mood (Profile of Mood States, POMS), self-efficacy (General Self-Efficacy Scale, GSE), mindfulness (Mindfulness Attention Awareness Scale, MAAS), and self-compassion (Self-Compassion Scale, SCS). At week 1, POMS depression and fatigue scores were significantly lower in F + LM compared to LM. At week 12, most self-report outcomes improved in both groups-only POMS vigor was significantly higher in F + LM than in LM. Most of the beneficial effects within the groups persisted at week 24. Fasting can induce mood-modulating effects in the short term. LM induced several positive effects on quality of life and psychological parameters in patients with MetS.

Published
2022

43. Stress Reduction by Yoga versus Mindfulness Training in Adults Suffering from Distress: A Three-Armed Randomized Controlled Trial including Qualitative Interviews (RELAX Study)

Author

Fischer, Jan Moritz, primary, Kandil, Farid-Ihab, additional, Kessler, Christian S., additional, Nayeri, Lucas, additional, Zager, Laura Sophie, additional, Rocabado Hennhöfer, Theresa, additional, Steckhan, Nico, additional, Koppold-Liebscher, Daniela A., additional, Bringmann, Holger C., additional, Schäfer, Thomas, additional, Michalsen, Andreas, additional, and Jeitler, Michael, additional

Published
2022
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44. Effects of Fasting and Lifestyle Modification in Patients with Metabolic Syndrome: A Randomized Controlled Trial

Author

Cramer, Holger, primary, Hohmann, Christoph, additional, Lauche, Romy, additional, Choi, Kyung-Eun (Anna), additional, Schneider, Nadia, additional, Steckhan, Nico, additional, Rathjens, Florian, additional, Anheyer, Dennis, additional, Paul, Anna, additional, von Scheidt, Christel, additional, Ostermann, Thomas, additional, Schneider, Elisabeth, additional, Koppold-Liebscher, Daniela A., additional, Kessler, Christian S., additional, Dobos, Gustav, additional, Michalsen, Andreas, additional, and Jeitler, Michael, additional

Published
2022
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46. Computerised cognitive training tools and online nutritional group counselling for people with mild cognitive impairment: study protocol of a completely digital, randomised, controlled trial

Author

Scheerbaum, Petra, primary, Book, Stephanie, additional, Jank, Michael, additional, Hanslian, Etienne, additional, DellO’ro, Melanie, additional, Schneider, Julia, additional, Scheuermann, Julia-Sophia, additional, Bösl, Sophia, additional, Jeitler, Michael, additional, Kessler, Christian, additional, and Graessel, Elmar, additional

Published
2022
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47. Ayurveda in Knee Osteoarthritis—Secondary Analyses of a Randomized Controlled Trial

Author

Kessler, Christian S, Jeitler, Michael; https://orcid.org/0000-0003-3277-9090, Dhiman, Kartar S, Kumar, Abhimanyu, Ostermann, Thomas; https://orcid.org/0000-0003-2695-0701, Gupta, Shivenarain, Morandi, Antonio, Mittwede, Martin, Stapelfeldt, Elmar, Spoo, Michaela, Icke, Katja; https://orcid.org/0000-0002-4170-8430, Michalsen, Andreas, Witt, Claudia M; https://orcid.org/0000-0002-5440-7805, Wischnewsky, Manfred B, Kessler, Christian S, Jeitler, Michael; https://orcid.org/0000-0003-3277-9090, Dhiman, Kartar S, Kumar, Abhimanyu, Ostermann, Thomas; https://orcid.org/0000-0003-2695-0701, Gupta, Shivenarain, Morandi, Antonio, Mittwede, Martin, Stapelfeldt, Elmar, Spoo, Michaela, Icke, Katja; https://orcid.org/0000-0002-4170-8430, Michalsen, Andreas, Witt, Claudia M; https://orcid.org/0000-0002-5440-7805, and Wischnewsky, Manfred B

Abstract

Background: Ayurveda is widely practiced in South Asia in the treatment of osteoarthritis (OA). The aim of these secondary data analyses were to identify the most relevant variables for treatment response and group differences between Ayurvedic therapy compared to conventional therapy in knee OA patients. Methods: A total of 151 patients (Ayurveda n = 77, conventional care n = 74) were analyzed according to the intention-to-treat principle in a randomized controlled trial. Different statistical approaches including generalized linear models, a radial basis function (RBF) network, exhausted CHAID, classification and regression trees (CART), and C5.0 with adaptive boosting were applied. Results: The RBF network implicated that the therapy arm and the baseline values of the WOMAC Index subscales might be the most important variables for the significant between-group differences of the WOMAC Index from baseline to 12 weeks in favor of Ayurveda. The intake of nutritional supplements in the Ayurveda group did not seem to be a significant factor in changes in the WOMAC Index. Ayurveda patients with functional limitations > 60 points and pain > 25 points at baseline showed the greatest improvements in the WOMAC Index from baseline to 12 weeks (mean value 107.8 ± 27.4). A C5.0 model with nine predictors had a predictive accuracy of 89.4% for a change in the WOMAC Index after 12 weeks > 10. With adaptive boosting, the accuracy rose to 98%. Conclusions: These secondary analyses suggested that therapeutic effects cannot be explained by the therapies themselves alone, although they were the most important factors in the applied models. Keywords: Ayurveda; traditional Indian medicine; knee osteoarthritis; complementary medicine; integrative medicine

Published
2022

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