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Therapeutic Area: Diabetes Background: Hypertension (HTN) and diabetes mellitus (DM) are both leading contributors to the development of cardiovascular disease (CVD). Furthermore, HTN subtypes may impact CVD outcomes to varying degrees. Data are limited on the association of HTN subtypes comparing those with versus without DM. The aim of this project is to examine the association of DM status with HTN subtypes. Methods: A total of 19,062 adults (projected to 39 million adults) from the National Health and Nutrition Examination Survey years 1999-2016 with untreated HTN, defined as a systolic blood pressure (BP) ≥ 130 or diastolic BP ≥ 80 mm Hg, were included in the analysis. Individuals were further stratified by HTN subtype: isolated systolic hypertension (ISH), isolated diastolic hypertension (IDH), and systolic-diastolic hypertension (SDH). Multiple logistic regression analyses examined the relation of diabetes and glycemic control to the likelihood of ISH. Results: Among the subjects examined, 16.4% had DM and among those a greater proportion (65%) had ISH compared to 36% in those without DM (p