124 results on '"Jeffrey Conn, P."'
Search Results
2. Modeling Intrahippocampal Effects of Anterior Hippocampal Hyperactivity Relevant to Schizophrenia Using Chemogenetic Excitation of Long Axis–Projecting Mossy Cells in the Mouse Dentate Gyrus
3. mGlu1 potentiation enhances prelimbic somatostatin interneuron activity to rescue schizophrenia-like physiological and cognitive deficits
4. Evaluation of Synthetic Cytochrome P450-Mimetic Metalloporphyrins To Facilitate 'Biomimetic' Biotransformation of a Series of mGlu5 Allosteric Ligands
5. A GRM7 mutation associated with developmental delay reduces mGlu7 expression and produces neurological phenotypes
6. Targeting metabotropic glutamate receptors for novel treatments of schizophrenia
7. 3293 Region Specific Dysregulation of Dopaminergic Signaling in Mice Displaying Excessive Over-Grooming
8. Development of allosteric modulators of GPCRs for treatment of CNS disorders
9. Positive allosteric modulators (PAMs) of the group II metabotropic glutamate receptors: Design, synthesis, and evaluation as ex-vivo tool compounds
10. Development of structurally distinct tricyclic M4 positive allosteric modulator (PAM) chemotypes - Part 2
11. Discovery of a novel class of heteroaryl-pyrrolidinones as positive allosteric modulators of the muscarinic acetylcholine receptor M1
12. Structure–activity relationships in a novel series of 7-substituted-aryl quinolines and 5-substituted-aryl benzothiazoles at the metabotropic glutamate receptor subtype 5
13. Lead optimization of the VU0486321 series of mGlu1 PAMs. Part 4: SAR reveals positive cooperativity across multiple mGlu receptor subtypes leading to subtype unselective PAMs
14. Contrasting adaptations to synaptic physiology of prefrontal cortex interneuron subtypes in a mouse model of binge drinking
15. Biased M1 positive allosteric modulators reveal novel role of phospholipase D in M1-dependent rodent cortical plasticity
16. Glutamate Approaches Towards the Treatment of Mood Disorders
17. MGluR5 mediates the interaction between late-LTP, network activity, and learning.
18. Correction: MGluR5 Mediates the Interaction between Late-LTP, Network Activity, and Learning.
19. Contrasting adaptations to synaptic physiology of prefrontal cortex interneuron subtypes in a mouse model of binge drinking
20. Biased M1positive allosteric modulators reveal novel role of phospholipase D in M1-dependent rodent cortical plasticity
21. Effects of typical and atypical antipsychotics on human glycine transporters
22. 3293 Region Specific Dysregulation of Dopaminergic Signaling in Mice Displaying Excessive Over-Grooming
23. Discovery of 4-alkoxy-6-methylpicolinamide negative allosteric modulators of metabotropic glutamate receptor subtype 5
24. The discovery of VU0652957 (VU2957, Valiglurax): SAR and DMPK challenges en route to an mGlu4 PAM development candidate
25. Activation of groups I or III metabotropic glutamate receptors inhibits excitatory transmission in the rat subthalamic nucleus
26. T39. NEURAL MECHANISMS OF METABOTROPIC GLUTAMATE RECEPTOR 3 MEDIATED ENHANCEMENT OF SYNAPTIC PLASTICITY AND COGNITION
27. Corrigendum to “Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides” [Bioorg. Med. Chem. Lett. 27(23) (2017) 5179–5184]
28. T227. THE METABOTROPIC GLUTAMATE RECEPTOR SUBTYPE 1 REGULATES STRIATAL DOPAMINE RELEASE VIA AN ENDOCANNABINOID-DEPENDENT MECHANISM: IMPLICATIONS FOR THE TREATMENT OF SCHIZOPHRENIA
29. T39. NEURAL MECHANISMS OF METABOTROPIC GLUTAMATE RECEPTOR 3 MEDIATED ENHANCEMENT OF SYNAPTIC PLASTICITY AND COGNITION
30. Discovery of ML326: The first sub-micromolar, selective M5 PAM
31. The Role of mGlu Receptors in Hippocampal Plasticity Deficits in Neurological and Psychiatric Disorders: Implications for Allosteric Modulators as Novel Therapeutic Strategies
32. Discovery and SAR of a novel series of non-MPEP site mGlu5 PAMs based on an aryl glycine sulfonamide scaffold
33. Development of novel M1 antagonist scaffolds through the continued optimization of the MLPCN probe ML012
34. Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptor
35. Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM
36. Development of a more highly selective M1 antagonist from the continued optimization of the MLPCN Probe ML012
37. Development of a highly selective, orally bioavailable and CNS penetrant M 1 agonist derived from the MLPCN probe ML071
38. Design and synthesis of substituted N-(1,3-diphenyl-1 H-pyrazol-5-yl)benzamides as positive allosteric modulators of the metabotropic glutamate receptor subtype 5
39. MAOS protocols for the general synthesis and lead optimization of 3,6-disubstituted-[1,2,4]triazolo[4,3- b]pyridazines
40. A novel class of H 3 antagonists derived from the natural product guided synthesis of unnatural analogs of the marine bromopyrrole alkaloid dispyrin
41. Discovery and SAR of novel mGluR5 non-competitive antagonists not based on an MPEP chemotype
42. Allosteric Modulators for the Treatment of Schizophrenia: Targeting Glutamatergic Networks
43. Development ofNovel, CNS Penetrant Positive AllostericModulators for the Metabotropic Glutamate Receptor Subtype 1 (mGlu1), Based on an N-(3-Chloro-4-(1,3-dioxoisoindolin-2-yl)phenyl)-3-methylfuran-2-carboxamideScaffold, That Potentiate Wild Type and...
44. Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moieties
45. Corrigendum to “Development of a scintillation proximity assay for analysis of Na+/Cl− -dependent neurotransmitter transporter activity” [Anal. Biochem. 321 (2003) 31–37]
46. Erratum to “Potent mGluR5 antagonists: Pyridyl and thiazolyl-ethynyl-3,5-disubstituted-phenyl series” [Bioorg. Med. Chem. Lett. 21 (2011) 3243–3247]
47. Design and synthesis of substituted N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides as positive allosteric modulators of the metabotropic glutamate receptor subtype 5
48. A novel class of H3 antagonists derived from the natural product guided synthesis of unnatural analogs of the marine bromopyrrole alkaloid dispyrin
49. Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders
50. Discovery of a Selective and CNS Penetrant NegativeAllosteric Modulator of Metabotropic Glutamate Receptor Subtype 3with Antidepressant and Anxiolytic Activity in Rodents.
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