1. Investigation of high gamma‐glutamyltransferase syndrome in California Thoroughbred racehorses
- Author
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Sichong Peng, K. Gary Magdesian, Joseph Dowd, Jeffrey Blea, Ryan Carpenter, Wayne Ho, and Carrie J. Finno
- Subjects
amylase ,genetics ,lipase ,vitamin E ,Veterinary medicine ,SF600-1100 - Abstract
Abstract Background Increases in serum gamma‐glutamyltransferase (GGT) activity have been reported in Thoroughbred (TB) racehorses and associated with maladaptation to training but the underlying etiology remains unknown. Hypothesis/Objectives Classify the etiology of high GGT syndrome in racing TBs by assessment of pancreatic enzymes, vitamin E concentrations, and both a candidate gene and whole genome association study. We hypothesized that a genetic variant resulting in antioxidant insufficiency or pancreatic dysfunction would be responsible for high GGT syndrome in TBs. Animals A total of 138 California racing TBs. Amylase: n = 31 affected (serum GGT activity ≥60 IU/L), n = 52 control (serum GGT activity
- Published
- 2022
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