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Your search keyword '"Jeffrey A, Tredup"' showing total 2 results
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2 results on '"Jeffrey A, Tredup"'

1. Discovery of N-[2-[2-[[3-Methoxy-4-(5-oxazolyl)phenyl]amino]-5-oxazolyl]phenyl]-N-methyl-4- morpholineacetamide as a Novel and Potent Inhibitor of Inosine Monophosphate Dehydrogenase with Excellent in Vivo Activity

Author

T G Murali, Dhar, Zhongqi, Shen, Junqing, Guo, Chunjian, Liu, Scott H, Watterson, Henry H, Gu, William J, Pitts, Catherine A, Fleener, Katherine A, Rouleau, N Z, Sherbina, Kim W, McIntyre, David J, Shuster, Mark R, Witmer, Jeffrey A, Tredup, Bang-Chi, Chen, Rulin, Zhao, Mark S, Bednarz, Daniel L, Cheney, John F, MacMaster, Laura M, Miller, Karen K, Berry, Timothy W, Harper, Joel C, Barrish, Diane L, Hollenbaugh, and Edwin J, Iwanowicz

Subjects
Male, Purine, Stereochemistry, Morpholines, Enzyme-Linked Immunosorbent Assay, Chemical synthesis, Mice, Structure-Activity Relationship, chemistry.chemical_compound, IMP Dehydrogenase, In vivo, IMP dehydrogenase, Drug Discovery, Animals, Structure–activity relationship, Nucleotide, Enzyme Inhibitors, Oxazoles, chemistry.chemical_classification, Mice, Inbred BALB C, biology, Mycophenolic Acid, Arthritis, Experimental, Rats, De novo synthesis, Biochemistry, chemistry, Rats, Inbred Lew, Enzyme inhibitor, Antibody Formation, biology.protein, Molecular Medicine
Abstract

Inosine monophosphate dehydrogenase (IMPDH) is a key enzyme that is involved in the de novo synthesis of purine nucleotides. Novel 2-aminooxazoles were synthesized and tested for inhibition of IMPDH catalytic activity. Multiple analogues based on this chemotype were found to inhibit IMPDH with low nanomolar potency. One of the analogues (compound 23) showed excellent in vivo activity in the inhibition of antibody production in mice and in the adjuvant induced arthritis model in rats.

Published
2002
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2. Discovery of N-[2-[2-[[3-Methoxy-4-(5-oxazolyl)phenyl]amino]-5-oxazolyl]phenyl]-N-methyl-4-morpholineacetamide as a Novel and Potent Inhibitor of Inosine Monophosphate Dehydrogenase (IMPDH) with Excellent in Vivo Activity

Author

T. G. Murali Dhar, Zhongqi Shen, Junqing Guo, Chunjian Liu, Scott H. Watterson, Henry H. Gu, William J. Pitts, Catherine A. Fleener, Katherine A. Rouleau, N. Z. Sherbina, Kim W. McIntyre, David J. Shuster, Mark R. Witmer, Jeffrey A. Tredup, Bang-Chi Chen, Rulin Zhao, Mark S. Bednarz, Daniel L. Cheney, John F. MacMaster, Laura M. Miller, Karen K. Berry, Timothy W. Harper, Joel C. Barrish, Diane L. Hollenbaugh, and Edwin J. Iwanowicz

Subjects
Drug Discovery, Molecular Medicine
Published
2002
Full Text
View/download PDF

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