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2. Effects of some clinically significant mycotoxins on the incorporation of DNA, RNA and protein precursors in cultured mammalian cells.

Author

Jeffery FH, Morton JG, and Miller JK

Subjects
Animals, Carcinoma, Squamous Cell, Cell Line, Cells, Cultured, Humans, L Cells drug effects, L Cells metabolism, Laryngeal Neoplasms, Mice, Ochratoxins pharmacology, T-2 Toxin pharmacology, Thymidine metabolism, Tritium, Zearalenone pharmacology, Leucine metabolism, Mycotoxins pharmacology, Uridine metabolism
Abstract

The effects of zearalenone (F-2), ochratoxin A and T-2 toxins on the synthesis of DNA, RNA and proteins in mouse L cells were studied. F-2 toxin inhibited protein synthesis to a lesser extent than DNA and RNA synthesis, whereas ochratoxin A inhibited the synthesis of each equally. Exposure to the toxins for 24 hours relatively reduced the synthetic ability of the cells. T-2 toxin inhibited protein and DNA synthesis in parallel but RNA synthesis to a lesser extent. Enhanced incorporation of tritiated thymidine was found when L cells were exposed to 0.4 to 0.016 ng of T-2 toxin ml-1 for 24 hours.

Published
1984

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