17 results on '"Jee Yeon Baek"'
Search Results
2. The impact of non-pharmaceutical interventions on premature births during the COVID-19 pandemic: a nationwide observational study in Korea
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Ji Young Lee, Joonsik Park, Myeongjee Lee, Minkyung Han, Inkyung Jung, Sung Min Lim, Jee Yeon Baek, Ji-Man Kang, Min Soo Park, and Jong Gyun Ahn
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COVID-19 ,lockdown ,non-pharmaceutical intervention ,prematurity ,preterm birth ,Pediatrics ,RJ1-570 - Abstract
BackgroundNon-pharmaceutical interventions (NPIs), such as social distancing and hand washing, have been associated with a decline in the preterm birth rate worldwide. We aimed to evaluate whether the preterm birth rate in Korea during the coronavirus disease 2019 lockdown has changed compared to that in previous years.MethodA birth registry from the Korea Statistical Information Service, which is a nationwide official database, was used to include all births claimed to have occurred between 2011 and 2020. Newborns with gestational age (GA) less than 22 weeks and birth weight less than 220 g were excluded. The pre-NPI period was designated as January 2011 to January 2020, and the NPI period was defined as February 2020 to December 2020. We assessed the effect of NPI on the incidence of prematurity per 100 births using an interrupted time-series quasi-experimental design and implementing an autoregressive integrated moving average (ARIMA) model.ResultsFrom 2011 to 2020, a total of 3,931,974 live births were registered, among which 11,416 were excluded. Consequently, the final study population included 3,920,558 live births (both singleton and multiple births) among which 275,009 (7.0%) were preterm. The preterm birth rate was significantly higher during the NPI period (8.68%) compared to that in the pre-NPI period (6.92%) (P
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- 2023
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3. Safety of Live Immunization in DiGeorge Syndrome: A Retrospective Single-Center Study in Korea, 2005–2021
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Sung Min Lim, Je Hee Shin, Jee Yeon Baek, Ji Young Lee, Ji-Man Kang, and Jong Gyun Ahn
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live immunization ,DiGeorge syndrome ,adverse events ,vaccination ,immunodeficiency ,Medicine - Abstract
Live immunization is contraindicated in patients with DiGeorge syndrome (DGS). We retrospectively investigated the occurrence of adverse events after live immunization in patients with DGS in Korea. The data of patients matching the International Classification of Disease-10 code of DGS (D82.1) at Severance Hospital Seoul, Korea, were extracted; patients without genetically diagnosed DGS were excluded. Based on T cell immunity status, the included patients were categorized into group A (CD3 < 500 or CD8 < 200 cells/mm3); group B (CD3 ≥ 500 and CD8 ≥ 200 cells/mm3); or group C (unknown). Among 94 patients, 38 (~40%, group A: 8 [21%]; group B: 30 [79%]) underwent immunological testing and 73 (~80%) received at least one live immunization (measles–mumps–rubella vaccination was most common [66/94, ~70%]). Fifty adverse events (fever [n = 29], upper respiratory infection [n = 9], diarrhea [n = 4], rash [n = 3], thrombocytopenia [n = 3], injection site pus [n = 1], and febrile convulsion [n = 1]) were observed; 13 (26%) occurred in group A, with no significant difference in incidence between groups A and B. Serious adverse events, including intensive care unit hospitalization or death, or diseases due to vaccine strains were not observed. In this study, live immunization was well tolerated by patients with partial DGS.
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- 2022
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4. The First Case of a Korean Patient with a MutationConfirmed Tumor Necrosis Factor Receptor-Associated Periodic Syndrome.
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Seok-Jin Lee, Jee Yeon Baek, Ji Young Lee, Ji-Man Kang, and Jong Gyun Ahn
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Tumor necrosis factor receptor-associated periodic syndrome (TRAPS, OMIM: #142680) is a rare autoinflammatory disease (AID) with recurrent febrile episodes. To our knowledge, we report herein the first case of a patient with TRAPS in South Korea whose symptoms included fever, arthralgia, abdominal pain, rash, myalgia, cough, and lymphadenopathy. A pathogenic de novo mutation, c.175T>C (p.Cys59Arg), in the tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) gene, was confirmed by gene sequencing. The patient has been with tocilizumab (an interleukin-6 inhibitor); tocilizumab administration every other week has completely alleviated the patient’s symptoms. Our report further expands the clinical spectrum of patients with TRAPS and reaffirms the use of tocilizumab as a viable alternative treatment option for those patients who are unsatisfactorily responsive to other commonly used biologics, such as canakinumab, anakinra, infliximab, and etanercept. Furthermore, our report may aid in increasing awareness about the existence of mutation-confirmed TRAPS in South Korea in addition to emphasizing the importance of actively pursuing genetic testing to correctly diagnose rare AID. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Incidence of Dental Discoloration After Tetracycline Exposure in Korean Children: A Nationwide PopulationBased Study.
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Ji Young Lee, Eun Hwa Kim, Myeongjee Lee, Jehee Shin, Sung Min Lim, Jee Yeon Baek, MinYoung Kim, Jong Gyun Ahn, Chung-Min Kang, Inkyung Jung, and Ji-Man Kang
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DENTAL discoloration ,TETRACYCLINE ,DOXYCYCLINE ,CONFIDENCE intervals ,ANTIBIOTICS - Abstract
This article discusses a study conducted in Korea that examined the incidence of dental discoloration in children who were prescribed tetracyclines. The study found that the occurrence of dental discoloration was relatively low and that tetracycline exposure did not increase the risk of dental discoloration compared to the general population. The authors suggest that the age restriction for prescribing tetracyclines may need to be reevaluated. The study also identified certain risk factors for dental discoloration, such as being female and having respiratory and metabolic comorbidities. [Extracted from the article]
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- 2024
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6. Aetiology and Prognosis of Encephalitis in Korean Children: A Retrospective Single-Centre Study, 2005-2020.
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Ahra Kim, Minyoung Kim, Jee Yeon Baek, Ji Young Lee, Se Hee Kim, Ji-Man Kang, Jong Gyun Ahn, and Hoon-Chul Kang
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Purpose: Encephalitis is a heterogeneous syndrome that occurs in childhood and is not rare. However, epidemiological studies of encephalitis based on the International Encephalitis Consortium (ICS) and expert recommendations are lacking. We investigated the aetiology and prognosis of encephalitis in Korean children. Materials and Methods: This retrospective study included children aged <19 years hospitalised for encephalitis at Severance Children's Hospital between 2005 and 2020. The 2013 ICS criteria were used to diagnose encephalitis, and causality was classified according to the site from which the specimen was obtained. Neurological sequelae were categorised using the modified Rankin Scale (mRS) score. Results: In total, 551 children were included, with 7% classified as possible, 77% as probable, and 15% as proven cases. A cause was identified in 42% of the cases (n=222), with viruses being the most common (42%), followed by bacteria (38%) and autoimmune encephalitis (12%). In cases of proven/probable encephalitis (n=65), bacteria accounted for 52%, followed by viruses (25%) and au- toimmune encephalitis (22%). In cases with a single pathogen, the anti-N-methyl-D-aspartate receptor autoantibody (n=14) was the most common, followed by Group B streptococcus (n=13), herpes simplex virus (n=11), enterovirus (n=4), and others. Approxi- mately 37% of patients had severe sequelae (mRS score ≥3) at discharge, which decreased to 31% 6 months after discharge. Conclusion: This large-scale study showed that autoimmune and infectious causes accounted for a significant proportion of en- cephalitis in Korean children. Further studies are needed to determine whether early targeted treatment following early diagnosis leads to a favourable prognosis in these populations. [ABSTRACT FROM AUTHOR]
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- 2024
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7. Comparison of Clinical Characteristics and Risk Factors for Recurrence of Kikuchi–Fujimoto Disease Between Children and Adult
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Jee Yeon Baek, Ji-Man Kang, Ji Young Lee, Sung Min Lim, and Jong Gyun Ahn
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Immunology ,Immunology and Allergy ,Journal of Inflammation Research - Abstract
Jee Yeon Baek,1 Ji-Man Kang,1,2 Ji Young Lee,1 Sung Min Lim,1 Jong Gyun Ahn1,2 1Department of Pediatrics, Severance Childrenâs Hospital, Yonsei University College of Medicine, Seoul, Korea; 2Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, KoreaCorrespondence: Jong Gyun Ahn, Department of Pediatrics, Severance Childrenâs Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea, Tel +82-2-2228-2057, Fax +82-2-393-9118, Email JGAHN@yuhs.acPurpose: KikuchiâFujimoto disease (KFD) is a rare, benign, and self-limited disease, characterized by cervical lymphadenopathy and fever. Herein, we analyzed the differences in its clinical manifestations and risk factors for recurrence between children and adults.Patients and Methods: We retrospectively reviewed the medical records of patients diagnosed with KFD at a tertiary referral hospital between 2005 and 2019. Patients were divided into two groups based on their age: children (< 19 years) and adults (⥠19 years).Results: During the 14-year study period, 127 patients were diagnosed with KFD. Among these, 34 (26.8%) were children and 93 (73.2%) were adults. The fever duration was longer and the frequency of myalgia was higher in adults than in children; however, no other significant symptomatic differences were noted between the two groups. Lymph node evaluation was mainly performed using ultrasound in children (61.8%) and computed tomography in adults (78.5%). Moreover, the frequency of antibiotic use was higher in children than in adults (76.5% vs 54.8%, P = 0.027). In adults, multivariable logistic regression analysis revealed anti-nuclear antibody (ANA) positivity (titer ⥠1:80) as a risk factor for recurrence (odds ratio: 7.813; 95% confidence interval = 1.818â 33.333; P = 0.006).Conclusion: The clinical features of KFD in children and adults were similar; however, the preferred imaging study and frequency of antibiotic use differed significantly between the two groups. Furthermore, in adults, ANA positivity was associated with KFD recurrence. Thus, patients with KFD who present with ANA positivity at diagnosis will benefit from a regular follow-up for monitoring KFD recurrence.Keywords: histiocytic necrotizing lymphadenitis, recurrence, child, adult
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- 2022
8. A decrease in the incidence of encephalitis in South Korea during the COVID‐19 pandemic: A nationwide study between 2010 and 2021
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Se Hee Kim, Jee Yeon Baek, Minkyung Han, Myeongjee Lee, Sung Min Lim, Ji Young Lee, Ji‐Man Kang, Inkyung Jung, Hoon‐Chul Kang, and Jong Gyun Ahn
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Infectious Diseases ,Virology - Published
- 2023
9. 2149. Risk of dental abnormalities after tetracycline exposure in children: A retrospective, population-based study in Korea, 2003-2015
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SeoJung Kim, Eun Hwa Kim, Myeongjee Lee, Je Hee Shin, Sung Min Lim, In Kyung Jung, Jong Gyun Ahn, Ji-Man Kang, Chung-Min Kang, Jee Yeon Baek, and Ji Young Lee
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Infectious Diseases ,Oncology - Abstract
Background Despite its clinical usefulness, the use of tetracycline antibiotics (TCs) in children has historically been limited because of the risk of permanent tooth discoloration and enamel deformity, although age restrictions have varied across countries (e.g., contraindicated under 8 years of age in Taiwan, USA, and Canada, and under 12 years of age in Korea and UK). We explored whether the incidence of dental abnormalities in Korean children with a history of TCs use differed by age. Furthermore, the relative risk compared to the TCs non-exposed group was calculated. Methods From 2002 to 2015, 1 million standard sample subjects data was provided from National Health Insurance Service in Korea. Children younger than 18 years were included and divided into groups A (0-7 years), B (8-12 years), and C (13-17 years). Subjects in 2002 were excluded for wash-out, as were those diagnosed with dental abnormalities within 6 months after TCs prescription. For comparison, 1:4 matching between the TCs exposure and non-exposure groups was performed according to age and gender. Results Among 14,831 individuals included as study subjects (487 (3%) in group A; 1,695 (11%) in group B; and 12,649 (85%) in group C), 201 (1.4%) were diagnosed with dental abnormalities. The 5-year cumulative incidence of dental abnormalities after exposure to TCs in the group A was 4.7%, which was significantly higher than that of the control group C (0.9%; p< 0.0001), but that of group B was 1.3% and not significantly different from that of group C. In the risk analysis of dental abnormalities according to exposure of TCs, there was no significant difference (adjusted RR=1.03, 95%CI=0.71 to 1.50 in group A; adjusted RR=1.13, 95%CI=0.76 to 1.69 in group B; adjusted RR=1.18, 95%CI=0.97 to 1.43 in group C). Fig 1.Cumulative incidence rate and relative risk analysis.A. Cumulative incidence rate of dental abnormalities after TCs exposure by age group (p = Conclusion Korean children aged 0-7 years who were exposed to TCs had a higher cumulative incidence and relative risk of dental deformities compared to the 13-17-year-old group but not the 8-12-year-old group. No significant increase in dental abnormalities was observed with TCs exposure among pediatric age groups. Disclosures All Authors: No reported disclosures.
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- 2022
10. 572. Adverse Events Following Live Immunization in Patients with DiGeorge Syndrome: A Retrospective, Single Center Study in Korea
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Sung Min Lim, Je Hee Shin, Jee Yeon Baek, Ji Young Lee, Ji-Man Kang, and Jong Gyun Ahn
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Infectious Diseases ,Oncology - Abstract
Background DiGeorge syndrome (DGS) is a syndrome accompanied by congenital heart defect, hypoparathyroidism and immunodeficiency of varying severity. Live vaccination is generally contraindicated in patients with DGS. However, in real clinical practice, there are cases in which live vaccines are immunized before the diagnosis of DGS or are incidentally immunized. We collected these cases and investigated adverse events (AEs), especially infections caused by the vaccine strains. Methods This retrospective study included all patients diagnosed with DGS at Severance Hospital Seoul, Korea, between November 2005 and June 2021. We extracted patients with ICD-10 code (D82.1) and then excluded subjects without genetic confirm. According to the immune status, subjects were categorized into three groups: group A [CD3 < 500 or CD8 < 200 (cells/mm3)], group B [CD3 ≥500 and CD8 ≥ 200 (cells/mm3)] and group C (unknown). Results Of a total 94 DGS patients, approximately 40% of subjects (38/94) underwent immunological test, of which 21% (8/38) belonged to group A and 79% (30/38) were in group B. Approximately 80% of study subjects (73/94) had a record of at least one live vaccination. By vaccine type, measles-mumps-rubella accounted for the most at 70% (66/94), followed by varicella, bacillus Calmette–Guérin, rotavirus, and live-attenuated Japanese encephalitis virus vaccine. A total of 50 AEs were observed (Figure 1): fever (n=29), URI (n=9), diarrhea (n=4), rash (n=3), thrombocytopenia (n=3), injection site pus (n=1) and febrile convulsion (n=1). Among them 26% (13/50) occurred in group A and no significant difference in the incidence rate of AEs between group A and B was observed (P = 0.14). Six cases of them turned out to be consistent with live vaccination by WHO 2009 causality analysis. Moreover, there were no serious reactions, including ICU hospitalization or death, and there was no emergence of disease caused by vaccine strains. Conclusion Our data show that live vaccines were often given without immunologic screening and generally well tolerated in our study population. Disclosures All Authors: No reported disclosures.
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- 2022
11. Risk of Dental Discoloration and Enamel Dysplasia in Children Exposed to Tetracycline and Its Derivatives
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Seo Jung Kim, Eun Hwa Kim, Myeongjee Lee, Jee Yeon Baek, Ji Young Lee, Jae Hee Shin, Sung Min Lim, Min Young Kim, Inkyung Jung, Jong Gyun Ahn, Chung-Min Kang, and Ji-Man Kang
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Asian People ,Databases, Factual ,Humans ,General Medicine ,Tetracycline ,Child ,Dental Enamel ,Anti-Bacterial Agents - Abstract
To examine the risk of dental abnormalities after exposure to tetracycline and its derivatives (TCs) in Korean children.Children aged 0-17 years with a claim for prescriptions of TCs between 2002 and 2015 were identified from the Sample Research Database 2.0 of the National Health Insurance Service. Children not exposed to TCs were selected as the control group by matching sex and age (1:4). Cumulative incidence rate and relative risk of dental abnormalities after TCs exposure were investigated.The 10-year cumulative incidence rate in the 0-12 years group was 3.1% [95% confidence interval (CI), 2.3-3.9]. The 10-year cumulative incidence rates were 7.0%, 1.9%, and 1.6% in the 0-7, 8-12, and 13-17 years age groups (95% CI: 4.7-9.3, 1.2-2.6, and 1.3-1.9, respectively). There was no significant difference in the risk of dental abnormalities according to TC exposure among the age groups of 0-7 years [adjusted hazard ratio (aHR)=1.0], 8-12 years (aHR=1.1), and 13-17 years (aHR=1.2).Short-term exposure to TCs does not appear to increase the risk of dental abnormalities in children aged 0-7 and 0-12 years. Restrictions on the use of TCs in children aged 8-12 years, in some countries, may warrant consideration.
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- 2022
12. Pathologic etiology and predictors of malignancy in children with cervical lymphadenopathy
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Jee Woo Kim, Jee Yeon Baek, Ji Young Lee, Sung Min Lim, Ji-Man Kang, Won Kee Ahn, Seung Min Hahn, Jung Woo Han, Chuhl Joo Lyu, and Jong Gyun Ahn
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Pediatrics, Perinatology and Child Health - Published
- 2022
13. Respiratory Syncytial Virus Outbreak Without Influenza in the Second Year of the Coronavirus Disease 2019 Pandemic: A National Sentinel Surveillance in Korea, 2021-2022 Season
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Jong-Hun Kim, Ha Yan Kim, Myeongjee Lee, Jong Gyun Ahn, Jee Yeon Baek, Min Young Kim, Kyungmin Huh, Jaehun Jung, and Ji-Man Kang
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Hospitalization ,Respiratory Syncytial Virus, Human ,COVID-19 ,Humans ,General Medicine ,Respiratory Syncytial Virus Infections ,Seasons ,Pandemics ,Sentinel Surveillance - Abstract
This study aimed to investigate whether respiratory syncytial virus (RSV) and influenza virus (IFV) infections would occur in 2021-2022 as domestic nonpharmaceutical interventions (NPIs) are easing.Data were collected from the Korean Influenza and Respiratory Virus Monitoring System database. The weekly positivity rates of respiratory viruses and number of hospitalizations for acute respiratory infections were evaluated (January 2016-2022). The period from February 2020 to January 2022 was considered the NPI period. The autoregressive integrated moving average model and Poisson analysis were used for data analysis. Data from 14 countries/regions that reported positivity rates of RSV and IFV were also investigated.Compared with the pre-NPI period, the positivity and hospitalization rates for IFV infection during 2021-2022 significantly decreased to 0.0% and 1.0%, respectively, at 0.0% and 1.2% of the predicted values, respectively. The RSV infection positivity rate in 2021-2022 was 1.8-fold higher than that in the pre-NPI period at 1.5-fold the predicted value. The hospitalization rate for RSV was 20.0% of that in the pre-NPI period at 17.6% of the predicted value. The re-emergence of RSV and IFV infections during 2020-2021 was observed in 13 and 4 countries, respectively.During 2021-2022, endemic transmission of the RSV, but not IFV, was observed in Korea.
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- 2022
14. Humoral immunogenicity of two doses of BNT162b2 in pediatric solid organ transplant recipients
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Jee Yeon Baek, Kyong Ihn, Hong Koh, Keum Hwa Lee, Min Young Kim, Sinyoung Kim, Ji-Man Kang, Jun Yong Choi, Younhee Park, and Myoung Soo Kim
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Transplantation ,Immunology - Published
- 2022
15. Pyogenic Spondylitis Caused by Nontyphoidal Salmonella in an Immunocompetent Child
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JEE YEON BAEK, JEHEE SHIN, Sung Min Lim, Ji-Man Kang, and Jong Gyun Ahn
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Infectious Diseases ,Pediatrics, Perinatology and Child Health - Published
- 2021
16. Geographic homogeneity and high gene flow of the pear psylla,Cacopsylla pyricola(Hemiptera: Psyllidae), detected by mitochondrial COI gene and nuclear ribosomal internal transcribed spacer 2
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Sang-Hyun Lee, Yeon Soo Han, Young-Sik Cho, Wol Soo Kim, Ah Rang Kang, Iksoo Kim, and Jee Yeon Baek
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education.field_of_study ,Genetic diversity ,PEAR ,fungi ,Population ,Biology ,General Biochemistry, Genetics and Molecular Biology ,Gene flow ,body regions ,Genetic structure ,Botany ,Biological dispersal ,Animal Science and Zoology ,Internal transcribed spacer ,education ,Ribosomal DNA - Abstract
The pear psylla, Cacopsylla pyricola (Hemiptera: Psyllidae), is a serious insect pest of commercial pear crops. The species, which resides on pear trees throughout its life cycle, is rapidly spreading in some regions of the world. The population genetic structure of the species collected from several pear orchards in Korea was studied to understand the nature of dispersal and field ecology of the species. The 658-bp region of mitochondrial COI gene and the 716-bp long complete internal transcribed spacer 2 (ITS2) of the nuclear ribosomal DNA were sequenced. Unlike other previously studied insect pests, the COI-based genetic diversity of the pear psylla was extremely low (maximum sequence divergence of 0.15%). This finding allowed us to conclude that the species may have been introduced in Korea relatively recently. ITS2 sequence-based analyses of phylogeny, population differentiation, gene flow, and hierarchical population structure all concordantly suggested that the pear psylla populations in K...
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- 2012
17. Complete nucleotide sequence and organization of the mitogenome of the red-spotted apollo butterfly, Parnassius bremeri (Lepidoptera: Papilionidae) and comparison with other lepidopteran insects
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Iksoo Kim, Byung Rae Jin, Man Il Kim, Ki-Gyoung Kim, Min Jee Kim, Yeon Soo Han, Heon Cheon Jeong, Chang Hwan Bae, and Jee Yeon Baek
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biology ,Base Sequence ,fungi ,Parnassius bremeri ,Endangered Species ,Genome, Insect ,Cell Biology ,General Medicine ,biology.organism_classification ,Lepidoptera genitalia ,Lepidoptera ,Monophyly ,Start codon ,Sister group ,RNA, Transfer ,Evolutionary biology ,Papilionoidea ,Bombycoidea ,Botany ,Animals ,Molecular Biology ,Pyraloidea ,Phylogeny - Abstract
The 15,389-bp long complete mitogenome of the endangered red-spotted apollo butterfly, Parnassius bremeri (Lepidoptera: Papilionidae) was determined in this study. The start codon for the COI gene in insects has been extensively discussed, and has long remained a matter of some controversy. Herein, we propose that the CGA (arginine) sequence functions as the start codon for the COI gene in lepidopteran insects, on the basis of complete mitogenome sequences of lepidopteran insects, including P. bremeri, as well as additional sequences of the COI start region from a diverse taxonomic range of lepidopteran species (a total of 53 species from 15 families). In our extensive search for a tRNA-like structure in the A+T-rich region, one tRNA(Trp)-like sequence and one tRNA(Leu) (UUR)-like sequence were detected in the P. bremeri A+T-rich region, and one or more tRNA-like structures were detected in the A+T-rich region of the majority of other sequenced lepidopteran insects, thereby indicating that such features occur frequently in the lepidopteran mitogenomes. Phylogenetic analysis using the concatenated 13 amino acid sequences and nucleotide sequences of PCGs of the four macrolepidopteran superfamilies together with the Tortricoidea and Pyraloidea resulted in the successful recovery of a monophyly of Papilionoidea and a monophyly of Bombycoidea. However, the Geometroidea were unexpectedly identified as a sister group of the Bombycoidea, rather than the Papilionoidea.
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- 2009
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