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This review describes the sex and gender differences in COVID-19 presentation, treatment, and outcomes. We discuss the differences between the sexes in susceptibility to infection, the role of sex chromosomes on the body's immunologic response and the influence of hormones on the body's response to the virus. Additionally, the sex differences in clinical and laboratory presentation, complications of infection and outcomes, as well as differences in response to treatment and prevention are reviewed.

Mounting evidence shows that biological sex and gender impacts how our bodies and brains work. As our traditional scientific model, heavily influenced by misguided policies and ingrained cultures, is rooted in the belief that males and females are interchangeable outside of our reproductive zones, it’s time for a scientific reboot. Depending upon the context, our chromosomes, hormones, and life experiences effect our lives in ways which are both inconsequential and critically important. To practice up-to-date medicine and optimize our own resiliency, it’s important to understand and openly discuss these very real differences. This introductory chapter is designed as a “sex and gender boot camp” and will review basic definitions, explore clinical and professional examples of sex and gender differences, provide a template for framing differences, and share the author’s personal experiences in discovering this material and using it to become more resilient.

The Sex and Gender in Emergency Medicine (SGEM) interest group of the Society of Academic Emergency Medicine (SAEM) was established to increase research and to disseminate knowledge about the influence of sex and/or gender in acute care medicine and on patient outcomes. To help facilitate these goals, over the past 4years, SGEM has created, delivered, and honed a Jeopardy-like scientific quiz game for the annual SAEM national meeting. Here we describe the SAEM Jeopardy Game's development, implementation, evolution, and outcomes as well as our targeted approach to access and engage emergency medicine stakeholders in its participation.

Background Emergency medicine (EM) residents do not generally receive sex- and gender-specific education. There will be increasing attention to this gap as undergraduate medical education integrates it within their curriculum. Methodology Members of the Sex and Gender in Emergency Medicine (SGEM) Interest Group set out to develop a SGEM toolkit and pilot integrating developed components at multiple residency sites. The curriculum initiative involved a pre- and posttraining assessment that included basic demographics and queries regarding previous training in sex-/gender-based medicine (SGBM). It was administered to PGY-1 to -4 residents who participated in a 3-hour training session that included one small group case-based discussion, two oral board cases, and one simulation and group debriefing. Analysis Components of the developed toolkit (https://www.sexandgenderhealth.org) were implemented at four unique SGEM Interest Group member residency programs. Residents (n = 82/174, 47%) participated; 64% (n = 49) were male and 36% (n = 28) were female. Twenty-six percent (n = 21) of the residents reported that they had less than 1 hour of training in this domain during residency; 59% (n = 48) reported they had 1 to 6 hours and 16% (n = 13) reported they had >6 hours. The average preassessment score was 61% and postassessment was 88%. After training, 74% (n = 60) felt that their current practice would have benefited from further training in sex-/gender-based topics in medicine during medical school and 83% (n = 67) felt their clinical practice would have benefited from further training in this domain during residency. Implications The majority of EM residents who participated in this training program reported that they had limited instruction in this domain in medical school or residency. This initiative demonstrated a method that can be emulated for the incorporation of SGBM educational components into an EM residency training educational day. After training, the majority of residents who participated felt that their current practice would have benefited from further training in sex- and gender-based topics in residency.

Academic Emergency Medicine publishes selected peer-reviewed videos that present state-of-the-art research, practice, and evidence in the field of emergency medicine. These videos are referred to as peer-reviewed lectures (PeRLs). This commentary reviews considerations for creating, filming, and producing high-quality PeRLs videos.

The objective of this study was to determine if judicious dosing of morphine sulfate can provide pain relief without changing important physical examination findings in patients with acute appendicitis. We conducted a prospective, randomized, double-blind crossover design. Patients scheduled for appendectomy were randomized to two groups. Group A received 0.075 mg/kg intravenous morphine sulfate and 30 minutes later received placebo. The sequence of medication was reversed in group B. Patients were examined by a surgical resident and an EM attending before and after receiving medication. Six explicit physical examination findings were documented as absent, indeterminate, or present. Physicians were also asked if they felt overall examination findings had changed after medication. Patient's visual analog scale (VAS) was recorded before each medication and at study completion. Thirty-four patients were enrolled and full data were available for 22 patients. Neither morphine nor placebo caused a significant change in individual examination findings. Three patients in both groups were judged to have a change in their examination after medication. The median change in VAS was 20 mm after morphine and 0 mm after placebo (P =.01). In this pilot study, patients with clinical signs of appendicitis were treated with morphine and had significant improvement of their pain without changes in their physical examination.

Introduction: Pain Scales Such As The 100-MM Visual Analog Scale And The 10-POINT Numeric Rating Scale Are Used To Describe Pain Intensity. The Visual Analog Scale And The Numeric Rating Scale Provide Accurate Descriptors For A Patient'S Perceived Level Of Pain. But How Accurate Or Reliable Is A Patient'S Perception Of Pain? Methods: To Test The Relationship Between The Intensity Of The Pain Stimulus And Pain Perception, We Devised An Experiment Using A Convenience Sample Of 20 Healthy Adult Volunteers. A Cutaneous Nerve Stimulator Delivered A Series Of Shocks Of Increasing Intensity To The Individual Via A Pediatric Ekg Electrode. The Participants Indicated Their Threshold For "INTOLERABLE Pain." With Use Of This Same Level Of Stimulus In Subsequent Shocks, The Participants, Blinded To The Amount Of Stimulus, Were Then Asked To Rate Each Shock As Either "THE Same," "A Little Less," Or "A Little More" Than The Baseline Stimulus. They Then Recorded Their Vas Score For Each Stimulus. Results: "INTOLERABLE Pain" Varied Widely Between 8 Mm To 73 Mm; Likewise, The Level Of Stimulus That Produced This Pain Ranged From 4 To 9. Once A Person'S Threshold Of "INTOLERABLE Pain" Had Been Reached, 49% Of The Subsequent Shocks Were Perceived As Different, Even Though The Stimulus Was Exactly The Same. Discussion: This Experiment Showed That (1) Given The Same Intensity Of Pain Stimulus, Different Persons Have Different Perceptions Of Pain; And (2) The Same Intensity Of Pain Stimulus, Given To The Same Person Repeatedly, Does Not Result In The Same Self-REPORT Of Pain Intensity.

Purpose: To determine the accuracy of CT and ultrasonography (US) in diagnosing appendicitis in adults stratified to either modality on the basis of body mass index (BMI), a measure of body habitus. Methods: Seventy-two adults with suspected appendicitis and demonstrating atypical clinical features were prospectively stratified to either appendiceal CT or US based on BMI. Patients with BMI < 30 underwent US and with BMI ≥ 30 underwent CT. Outcomes were determined by surgery, the medical record, and clinical follow-up after 3 months. Results: Of the 72 patients enrolled, 30 (24 women and 6 men) underwent CT and 42 (35 women and 7 men) underwent US. The average BMI was 34 ± 4 among patients who had CT and 24 ± 3 among patients who had US. Of the patients who had CT scans, 4 had positive scans for appendicitis and all of these were proven at surgery to have appendicitis. The remaining 26 patients had negative CT scans for appendicitis. Twenty-two of these were subsequently proven either by surgery or clinical follow-up not to have appendicitis, while 4 were lost to follow-up. This corresponds to a sensitivity, specificity, positive predictive value, and negative predictive value of 100 %. Twelve ultrasound examinations were positive for appendicitis. Nine of these patients had appendicitis proven at surgery, 1 had a perforated Meckel's diverticulum, and 2 did not have appendicitis after clinical follow-up. Twenty-seven patients had negative ultrasound exams for appendicitis. However, 6 of these had appendicitis proven at surgery, 17 did not have appendicitis, and 4 were lost to follow-up. Three patients had ultrasound exams that were equivocal for appendicitis; of these, 1 had appendicitis and 2 did not. For US, this corresponds to a sensitivity of 60 %, specificity of 85 %, PPV of 75 %, and NPV of 74 %. Conclusion: This study suggests that CT is an accurate method of evaluating adults with suspected appendicitis who have BMI ≥ 30. Stratifying patients with BMI < 30 to US did not reproduce the results already reported in the literature.

Introduction: The new standards of the joint commission on accreditation of healthcare organizations specify the patient's right to appropriate assessment and management of pain. With this impetus, we looked at our own practice to see how well we assess and manage patients with pain. Methods: Patients who presented with minor nonemergent pain were interviewed on arrival, and then again before discharge, with use of a structured questionnaire. A total of 68 completed pain surveys were analyzed. Results: With use of a visual analog scale, patients rated their pain on arrival and at discharge; they also rated pain they were willing to accept when it was time for discharge. Sixty percent of the patients went home with more pain than they were willing to accept. Fifty-one percent of the patients were offered something for pain, and only half of them said the pain relief was adequate. The median time from arrival to administration of pain medication was 104 minutes. Surprisingly, the median patient satisfaction rating for overall care was "very good." Discussion: This survey revealed that acute pain conditions are underevaluated and undertreated in one fast-track setting, suggesting that ED staff need more education about the management of acute pain. It also showed that relying on patient satisfaction surveys as surrogate markers for how well we manage pain is erroneous. J Emerg Nurs 2001;27:327-34.

Purpose: This prospective study compares the agreement of nonenhanced helical computed tomography (NECT) with oral contrast-enhanced computed tomogra- phy (CECT) in Emergency Department (ED) patients presenting with acute abdominal pain. Materials and methods: One hundred eighteen patients presenting to the ED with acute abdominal pain undergoing CT were enrolled over a 13-month period using convenience sampling. Exclusion criteria included acute trauma, pregnancy, unstable patients, and patients suspected of having urinary calculi. Patients were scanned helically using 5-mm collimation before and approximately 90 min after oral contrast administration. Both exams were prospectively interpreted by different attending radiologists in a blinded fashion using an explicit data sheet specifying the presence or absence of 28 param- eters relating to various common diagnoses. Results: The 118 patients had a mean age of 49 years, a male: female ratio of 7:13, and a median height, weight, and BMI of 166 cm, 80 kg, and 29, respectively. The most common indications for the study included appendicitis (32%) and diverticular disease (12%). Pain maximally localized to the right lower quadrant in 37% and the left lower quadrant in 21%. There were 21 patients that had significant disagreement of interpretations between NECT and CECT resulting in a simple agreement of 79% (95% CI: 70-87%). For specific radiologic param- eters, agreement ranged from 77 to 100%. A post hoc agreement analysis was subsequently performed by two radiologists and only five paired scans were identified as discordant between the NECT and CECT. For only one of these patients did both radiologists agree that there was a definite discordant result between the two studies. A final unblinded consensus review demonstra- ted that much of the disagreement between the inter- pretations was related to interobserver variation. Conclusion: There is 79% simple agreement between NECT and CECT in diagnosing various causes of acute abdominal pain in adult ED patients. Post hoc analysis indicates that a significant portion of the discordance was attributable to interobserver variability. This data suggests that NECT should be considered in adult ED patients presenting with acute abdominal pain.

The aim of the study was to assess various time intervals during patient encounters involving unenhanced (NECT) versus oral-contrast-enhanced (CECT) abdominopelvic (A/P) CT performed in the emergency department (ED) on adult patients presenting with acute abdominal pain. Computerized patient order entry and administrative data as well as scans themselves were retrospectively evaluated at a high-volume (107,000 visits per annum) regional medical center urban ED for a period of 30 consecutive days. All adult patients who had CT of abdomen and pelvis for abdominal pain during the 30 days of the study period were included. Data collected included demographic information, time of registration, time of first encounter in the ED, time of CT order, clinical indication for scan, time of scan, time of disposition (i.e., discharge or admit), and final disposition. Patients were excluded if they were less than 16 years old, pregnant, or met criteria for major trauma and evaluation in the trauma suite. Patients were also excluded from analysis if they received more than one scan on the same day (3 patients). Of 183 patients, 102 underwent NECT and 81 CECT. Some of the patients who underwent NECT had urinary colic. Among patients who did not have urinary colic there is a statistically significant difference in the median time intervals between: (1) patient arrival in the ED and evaluation by a physician (NECT 57 min, CECT 84 min, P

Vocal cord dysfunction is a rare type of airway obstruction that may mimic an acute asthma attack. We present a case of a patient who arrived in the Emergency Department (ED) in acute respiratory distress, with a history of severe asthma requiring previous intubation, who was diagnosed with vocal cord dysfunction by bronchoscopy in the ED.

Study objective: Examination of alcohol consumption patterns of male spectators at two major-league baseball stadiums. Methods: A prospective observational study was conducted at two stadiums over the course of three games at each venue. We approached 1,084 male spectators of drinking age in a consecutive fashion at two junctures: at the entrance gate and during the fifth inning inside the stadium's concourse. Of those approached, 747 (68.9%) participated. After verbal consent, participants completed a questionnaire and blew into a breath analyzer. The results were blinded and later analyzed. Results: Forty-one percent of all participants tested positive for alcohol. The highest consumption occurred in the 20- to 35-year-old age group. In this age group, 50.8% had consumed some alcohol, and 10.8% had a blood alcohol level of .08% (intoxicated) or higher. Almost 5% of all participants tested during the fifth inning collection were intoxicated and claimed to be driving. Conclusion: Of the spectators tested, those in the 20- to 35-year-old age group were most likely to have consumed alcohol and to be legally intoxicated. A disturbing number of spectators who had blood alcohol levels of .08% or higher late in the game claimed to be driving home. [Wolfe J, Martinez R, Scott WA: Baseball and beer: An analysis of alcohol consumption patterns among male spectators at major-league sporting events. Ann Emerg Med May 1998;31:629-632.]