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1. Abdominal Aortic Calcifications Influences the Systemic and Renal Hemodynamic Response to Renal Denervation in the DENERHTN (Renal Denervation for Hypertension) Trial

Author: Pierre‐Yves Courand, Helena Pereira, Costantino Del Giudice, Philippe Gosse, Matthieu Monge, Guillaume Bobrie, Pascal Delsart, Claire Mounier‐Vehier, Pierre Lantelme, Thierry Denolle, Caroline Dourmap, Jean Michel Halimi, Xavier Girerd, Patrick Rossignol, Faiez Zannad, Olivier Ormezzano, Bernard Vaisse, Daniel Herpin, Jean Ribstein, Beatrice Bouhanick, Jean‐Jacques Mourad, Emile Ferrari, Gilles Chatellier, Marc Sapoval, Arshid Azarine, and Michel Azizi
Subjects: antihypertensive therapy/sympathetic nervous system, aortic calcification, aortic disease, atherosclerosis, renal denervation, resistant hypertension, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: BackgroundThe DENERHTN (Renal Denervation for Hypertension) trial confirmed the efficacy of renal denervation (RDN) in lowering daytime ambulatory systolic blood pressure when added to standardized stepped‐care antihypertensive treatment (SSAHT) for resistant hypertension at 6 months. Methods and ResultsThis post hoc exploratory analysis assessed the impact of abdominal aortic calcifications (AAC) on the hemodynamic and renal response to RDN at 6 months. In total, 106 patients with resistant hypertension were randomly assigned to RDN plus SSAHT or to the same SSAHT alone (control group). Total AAC volume was measured, with semiautomatic software and blind to randomization, from the aortic hiatus to the iliac bifurcation using the prerandomization noncontrast abdominal computed tomography scans of 90 patients. Measurements were expressed as tertiles. The baseline‐adjusted difference in the change in daytime ambulatory systolic blood pressure from baseline to 6 months between the RDN and control groups was −10.1 mm Hg (P=0.0462) in the lowest tertile and −2.5 mm Hg (P=0.4987) in the 2 highest tertiles of AAC volume. Estimated glomerular filtration rate remained stable at 6 months for the patients in the lowest tertile of AAC volume who underwent RDN (+2.5 mL/min per 1.73 m2) but decreased in the control group (−8.0 mL/min per 1.73 m2, P=0.0148). In the 2 highest tertiles of AAC volume, estimated glomerular filtration rate decreased similarly in the RDN and control groups (P=0.2640). ConclusionsRDN plus SSAHT resulted in a larger decrease in daytime ambulatory systolic blood pressure than SSAHT alone in patients with a lower AAC burden than in those with a higher AAC burden. This larger decrease in daytime ambulatory systolic blood pressure was not associated with a decrease in estimated glomerular filtration rate. Clinical Trial RegistrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT01570777.
Published: 2017
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2. Sodium excretion is higher in patients with rheumatoid arthritis than in matched controls.

Author: Sarah Marouen, Guilhem du Cailar, Rachel Audo, Cedric Lukas, Gaelle Vial, Anne Tournadre, Emmanuel Barrat, Jean Ribstein, Bernard Combe, Jacques Morel, and Claire I Daien
Subjects: Medicine, Science
Abstract: It was shown that sodium can promote auto-immunity through the activation of the Th17 pathway. We aimed to compare sodium intake in patients with rheumatoid arthritis (RA) vs. matched controls.This case-control study included 24 patients with RA at diagnosis and 24 controls matched by age, gender and body mass index. Sodium intake was evaluated by 24-hr urinary sodium excretion.Sodium excretion was greater for patients with early RA (2,849±1,350 vs. 2,182±751.7mg/day, p = 0.039) than controls. This difference remained significant after adjustment for smoking and the use of anti-hypertensive and nonsteroidal anti-inflammatory drugs (p = 0.043). Patients with radiographic erosion at the time of diagnosis had a higher sodium excretion than those without (p = 0.028).Patients with early RA showed increased sodium excretion which may have contributed to autoimmunity.
Published: 2017
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3. Place of the 18F-FDG-PET/CT in the Diagnostic Workup in Patients with Classical Fever of Unknown Origin (FUO)

Author: Denis Mariano-Goulart, Philippe Guilpain, Marie-Christine Picot, Camille Roubille, S. Letertre, Vincent Le Moing, Jean Ribstein, Laetitia Zerkowski, Pierre Fesler, Hôpital Lapeyronie [Montpellier] (CHU), CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Université de Montpellier (UM), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), CIC Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Saint Eloi (CHRU Montpellier), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Saint Eloi (CHRU Montpellier), MORNET, Dominique, Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-CHU Saint-Eloi-Institut National de la Santé et de la Recherche Médicale (INSERM), and CHU Saint-Eloi
Subjects: medicine.medical_specialty, Multivariate analysis, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Population, 18F-FDG-PET/CT, Article, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Biopsy, medicine, In patient, 030212 general & internal medicine, Fever of unknown origin, Medical diagnosis, education, education.field_of_study, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, medicine.diagnostic_test, Adult patients, business.industry, General Medicine, medicine.disease, 3. Good health, [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, fever of unknown origin, Medicine, Fdg pet ct, Radiology, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: Objective: To explore the diagnostic contribution of the 18F-FDG-PET/CT in a population of patients with classical fever of unknown origin (FUO), to pinpoint its place in the diagnostic decision tree in a real-life setting, and to identify the factors associated with a diagnostic 18F-FDG-PET/CT. Method: All adult patients (aged ≥ 18 years) with a diagnosis of classical FUO who underwent an 18F-FDG-PET/CT in the University Hospital of Montpellier (France) between April 2012 and December 2017 were included. True positive 18F-FDG-PET/CT, which evidenced a specific disease causing FUO, were considered to be contributive. Results: Forty-four patients with FUO have been included (20 males, 24 females, mean age 57.5 ± 17.1 years). Diagnoses were obtained in 31 patients (70.5%), of whom 17 (38.6%) had non-infectious inflammatory diseases, 9 had infections (20.5%), and 3 had malignancies (6.8%). 18F-FDG-PET/CT was helpful for making a final diagnosis (true positive) in 43.6% of all patients. Sensitivity and specificity levels were 85% and 37%, respectively. A total of 135 investigations were performed before 18F-FDG-PET/CT, mostly CT scans (93.2%) and echocardiography (59.1%), and 108 after 18F-FDG-PET/CT, mostly biopsies (including the biopsy of a temporal artery) (25%) and MRIs (34%). In multivariate analysis, the hemoglobin level was significantly associated with a helpful 18F-FDG-PET/CT (p = 0.019, OR 0.41, 95% CI (0.20–0.87)), while the CRP level was not associated with a contributive 18F-FDG-PET/CT. Conclusion: 18F-FDG-PET/CT may be proposed as a routine initial non-invasive procedure in the diagnostic workup of FUO, especially in anemic patients who could be more likely to benefit from 18F-FDG-PET/CT.
Published: 2021
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4. Confidence vanished or impaired until distrust in the doctor-patient relationship because of COVID-19

Author: Camille Roubille, Pierre Fesler, Jean Ribstein, Eric Fiat, Gerard Hurpin, François Roubille, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)
Subjects: Coronavirus disease 2019 (COVID-19), media_common.quotation_subject, [SDV]Life Sciences [q-bio], good practice, 030204 cardiovascular system & hematology, History, 21st Century, Article, History, 17th Century, 03 medical and health sciences, 0302 clinical medicine, Nothing, Health care, Internal Medicine, Humans, 030212 general & internal medicine, Practice Patterns, Physicians', Precision Medicine, Epidemics, Pandemics, Mental suffering, ComputingMilieux_MISCELLANEOUS, media_common, Physician-Patient Relations, Distrust, SARS-CoV-2, business.industry, Perspective (graphical), Gastroenterology, Cornerstone, COVID-19, trust, Telemedicine, doctor-patient relationship, 3. Good health, Doctor–patient relationship, confidence, Psychology, business, Social psychology
Abstract: Since Hippocrates, the cornerstone of medical practice has been the doctor-patient relationship. The question here is whether these basic principles are still compatible with this unusual COVID-period. This pandemic represents a serious threat to human health, leading to profound changes in behavior in daily life but also in health care. Because of limited resources, health-managers must choose well-balanced solutions able to protect patients and citizens on the one hand and to provide maximal benefit for the society on the other hand. We are going through a moment of rupture that we must acknowledge. Here, we discussed how the doctor-patient relationship could be compromised. Doctors are focused on cares whereas patients are focused on scare. Profound changes occur presently, from the way we present ourselves to each other (including the masks), the poor conditions for physical examination, the mental suffering of both patient and caregiver until sometimes terrible end-of-life conditions. The historical point-of-view helps us to keep in mind previous experiences, and the philosophical perspective helps to contextualize this unedited situation. We should stop briefly our daily rush to put these considerations into perspective to overcome these challenges. Nothing is as effective as trust: let's rebuild it.
Published: 2020
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5. [Expert consensus statement on blood pressure measurement from the French Society of Hypertension, an affiliate of the French Society of Cardiology]

Author: Thierry Denolle, Roland Asmar, Jean-Marc Boivin, Xavier Girerd, Sylvain Le Jeune, Bernard Vaisse, Yara Antakly-Hanon, Mathieu Artifoni, André Atallah, Christophe Bachelet, Nicolas Barber-Chamoux, Theodora Bejan-Angoulvant, Jacques Blacher, Romain Boulestreau, François Chantrel, Yves Dimitrov, Gérard Doll, Giselle Dugelay, Béatrice Duly-Bouhanick, Philippe Gosse, Dominique Guerrot, Faiçal Jarraya, Guillaume Lamirault, Benoit Lequeux, Marilucy Lopez-Sublet, Alain Mercier, Laurène Millet, Claire Mounier-Véhier, Jean-Jacques Mourad, Edgar Nasr, Olivier Ormezzano, Laurence Perez, Alexandre Persu, Jean Ribstein, François Silhol, Philippe Sosner, Elisabeth Steyer, Mohamed Temmar, Philippe Van De Borne, Emmanuelle Vidal-Petiot, Service de cardiologie et maladies vasculaires [Rennes] = Cardiac, Thoracic, and Vascular Surgery [Rennes], CHU Pontchaillou [Rennes], Société française d’hypertension artérielle (SFHTA), Département de médecine générale [Univ. Lorraine], Université de Lorraine (UL), Service d'Endocrinologie, Métabolisme et Prévention des Maladies Cardio-vasculaires [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital de la Timone [CHU - APHM] (TIMONE), Service de médecine interne [Nantes], Université de Nantes (UN)-Hôtel-Dieu-Centre hospitalier universitaire de Nantes (CHU Nantes), CHU Clermont-Ferrand, Université de Tours (UT), Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle (CRESS - U1153), Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Bordeaux (UB), Centre Hospitalier Emile Muller [Mulhouse] (CH E.Muller Mulhouse), Groupe Hospitalier de Territoire Haute Alsace (GHTHA), Centre hospitalier de Haguenau, Hôpital Saint-André, Service de Néphrologie [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Endothélium, valvulopathies et insuffisance cardiaque (EnVI), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Sfax - University of Sfax, Unité de recherche de l'institut du thorax (ITX-lab), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Service de cardiologie [CHU de Poitiers], Centre hospitalier universitaire de Poitiers (CHU Poitiers), Hôpital cardiologique, Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Hôpital Avicenne [AP-HP], Clinique Cardiologie et Hypertension Artérielle, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-Hôpital Michallon, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Cliniques Universitaires Saint-Luc [Bruxelles], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Laboratoire 'Mobilité, Vieillissement, Exercice' (MOVE) (MOVE), Université de Poitiers, Hôpital Erasme [Bruxelles] (ULB), Faculté de Médecine [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB), Paris-Centre de Recherche Cardiovasculaire (PARCC - UMR-S U970), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), AP-HP - Hôpital Bichat - Claude Bernard [Paris], and Guerrot, Dominique
Subjects: medicine.medical_specialty, Evening, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, business.industry, General Medicine, 030204 cardiovascular system & hematology, Sitting, 3. Good health, 03 medical and health sciences, Orthostatic vital signs, Masked Hypertension, 0302 clinical medicine, Blood pressure, Drug control, Ambulatory, Physical therapy, Medicine, Observational study, 030212 general & internal medicine, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: International audience; Since 2016, the French Society of Hypertension has warned about the decline in the management of high blood pressure in France: stagnation, or even decreased number of people who know their blood pressure level, take a treatment and are controlled. These results are lower than those observed in many other countries. Blood pressure is measured with an old method in the doctor's office. Accepted, simple and cost-effective, this method is currently unavoidable for reasons of feasibility and social habit. It has been used in observational and intervention studies that are the basis of the medical reasoning for screening, treatment and drug control of hypertension. In practice, it is too often poorly applied and unpredictable. It is now necessary to measure blood pressure in mmHg using a validated oscillometric automatic device coupled to a specific upper arm cuff adapted to the arm circumferences for the diagnosis and monitoring of high blood pressure in the doctor's office and at home. The auscultatoric measurement is only recommended if any doubt about the reliability of the electronic measurement. Blood pressure measurement is basically performed on both arms to detect asymmetry and then on the arm with the highest blood pressure. It is performed in sitting or lying position after a few minutes of rest without speaking and without having smoked and then in standing position to diagnose orthostatic hypotension, especially in elderly, diabetic and multi-medicated subjects. The blood pressure measurement during the consultation must be repeated and include at least 3 consecutive measurements at one minute intervals. The average of the last 2 measurements determines the blood pressure level. It is recommended to perform BP measurements outside the medical environment for the diagnosis and monitoring of hypertension; Home BP measurement is preferred to ambulatory blood pressure measurement for practical reasons unless otherwise specified. The home blood pressure measurement should include three measurements in the morning at breakfast and three measurements in the evening before bedtime at one minute intervals for at least three days. Prior training must be provided. In treated hypertensive patients, a masked hypertension should be considered as an uncontrolled hypertension and antihypertensive therapy adapted accordingly. The measurement of central BP pressure (aorta) should be limited to clinical research.
Published: 2019
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6. Arterial stiffness: an independent determinant of adaptive glomerular hyperfiltration after kidney donation

Author: Pierre Fesler, Albert Mimran, Georges Mourad, Guilhem du Cailar, and Jean Ribstein
Subjects: Adult, Male, medicine.medical_specialty, Physiology, Urology, Renal function, Nephrectomy, Young Adult, Vascular Stiffness, Internal medicine, Living Donors, medicine, Humans, Longitudinal Studies, Prospective Studies, Aged, Kidney, business.industry, Kidney donation, Limiting, Middle Aged, medicine.disease, Adaptation, Physiological, Endocrinology, medicine.anatomical_structure, Multivariate Analysis, Arterial stiffness, Female, business, Glomerular hyperfiltration, Glomerular Filtration Rate
Abstract: After kidney donation, the remaining kidney tends to hyperfiltrate, thus limiting the initial loss of renal function. The potential determinants of this adaptive glomerular hyperfiltration (GHF) and specifically the influence of arterial function are poorly known. In 45 normotensive healthy kidney donors [51 ± 10 yr (mean ± SD), 39 females], glomerular filtration rate (GFR) was measured as the clearance of continuously infused99mTc-DTPA and timed urine collections at baseline, i.e., before donation, and 1 yr after donation. GHF was computed as postdonation GFR minus half of baseline GFR. Arterial function was assessed as baseline carotid-femoral pulse wave velocity (PWV) and carotid augmentation index (AIx). After kidney donation, no significant change in blood pressure (BP) was observed, but two subjects developed hypertension. GFR decreased from 107 ± 19 to 73 ± 15 ml·min−1·1.73 m−2, and mean GHF was 20 ± 10 ml·min−1·1.73 m−2. In univariate analysis, GHF was inversely correlated to age ( r2= 0.24, P = 0.01), baseline PWV ( r2= 0.23, P = 0.001), and Aix ( r2= 0.11, P = 0.031). Nevertheless, GHF was not correlated to baseline peripheral or central BP. In multivariate analysis, baseline PWV, but not AIx, remained inversely correlated to GHF, independently of age, baseline mean BP, and GFR (model r2= 0.34, P < 0.001). In healthy subjects selected for renal donation, increased arterial stiffness is associated with decreased postdonation compensatory hyperfiltration.
Published: 2015
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7. Sodium excretion is higher in patients with rheumatoid arthritis than in matched controls

Author: Jacques Morel, Jean Ribstein, R. Audo, Cédric Lukas, Emmanuel Barrat, Gaelle Vial, Claire Daien, Bernard Combe, Sarah Marouen, Anne Tournadre, Guilhem du Cailar, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Service de rhumatologie, Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Institut de Génétique Moléculaire de Montpellier (IGMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ), Unité de Nutrition Humaine - Clermont Auvergne ( UNH ), Université Clermont Auvergne ( UCA ) -Institut national de la recherche agronomique [Auvergne/Rhône-Alpes] ( INRA Auvergne/Rhône-Alpes ), Université Clermont Auvergne ( UCA ), Institut de Génétique Moléculaire de Montpellier ( IGMM ), Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Bicêtre, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), and Université Clermont Auvergne (UCA)
Subjects: Male, Physiology, NSAIDs, [SDV]Life Sciences [q-bio], Arthritis, lcsh:Medicine, Urine, 030204 cardiovascular system & hematology, Sodium Chloride, Gastroenterology, Biochemistry, Severity of Illness Index, Arthritis, Rheumatoid, 0302 clinical medicine, Rheumatoid, Medicine and Health Sciences, lcsh:Science, 2. Zero hunger, Analgesics, Multidisciplinary, Fatty Acids, Drugs, Middle Aged, Lipids, 3. Good health, Body Fluids, Chemistry, Antihypertensive Drugs, Rheumatoid arthritis, Physical Sciences, Female, Anatomy, Research Article, medicine.medical_specialty, Sodium, Immunology, Excretion, chemistry.chemical_element, Rheumatoid Arthritis, Autoimmune Diseases, 03 medical and health sciences, Rheumatology, Internal medicine, Severity of illness, medicine, Humans, Nutrition, 030203 arthritis & rheumatology, Pharmacology, [ SDV ] Life Sciences [q-bio], business.industry, lcsh:R, Case-control study, Chemical Compounds, Biology and Life Sciences, medicine.disease, Pain management, Diet, Endocrinology, chemistry, Case-Control Studies, Clinical Immunology, Salts, lcsh:Q, Clinical Medicine, business, Physiological Processes, Body mass index
Abstract: International audience; OBJECTIVE: It was shown that sodium can promote auto-immunity through the activation of the Th17 pathway. We aimed to compare sodium intake in patients with rheumatoid arthritis (RA) vs. matched controls. METHODS: This case-control study included 24 patients with RA at diagnosis and 24 controls matched by age, gender and body mass index. Sodium intake was evaluated by 24-hr urinary sodium excretion. RESULTS: Sodium excretion was greater for patients with early RA (2,849\textpm1,350 vs. 2,182\textpm751.7mg/day, p = 0.039) than controls. This difference remained significant after adjustment for smoking and the use of anti-hypertensive and nonsteroidal anti-inflammatory drugs (p = 0.043). Patients with radiographic erosion at the time of diagnosis had a higher sodium excretion than those without (p = 0.028). CONCLUSION: Patients with early RA showed increased sodium excretion which may have contributed to autoimmunity.
Published: 2017
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8. Left Ventricular Mass Changes After Renal Transplantation

Author: Jean Ribstein, Vincent Pernin, Pierre Fesler, Guilhem du Cailar, Benjamin Bonnet, Albert Mimran, Georges Mourad, Carole Oudot, and Hôpital Lapeyronie [Montpellier] (CHU)
Subjects: Male, Time Factors, [SDV]Life Sciences [q-bio], 030232 urology & nephrology, Blood Pressure, 030204 cardiovascular system & hematology, Left ventricular hypertrophy, Muscle hypertrophy, chemistry.chemical_compound, 0302 clinical medicine, Risk Factors, Prevalence, Medicine, Longitudinal Studies, Ultrasonography, education.field_of_study, Diet, Sodium-Restricted, Middle Aged, 3. Good health, Treatment Outcome, Cardiology, Female, Hypertrophy, Left Ventricular, France, Glomerular Filtration Rate, Adult, medicine.medical_specialty, Population, Renal function, Excretion, 03 medical and health sciences, Internal medicine, Humans, Sodium Chloride, Dietary, education, Transplantation, business.industry, medicine.disease, Kidney Transplantation, Dietary sodium, Endocrinology, Blood pressure, chemistry, Uric acid, business, Biomarkers, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: International audience; Background: We hypothesized that dietary sodium may modulate the effect of systolic blood pressure and other nonhemodynamic factors, such as high uric acid and renal dysfunction, on changes in the left ventricular mass after renal transplantation. The objective of the present 3-year follow-up longitudinal study was to assess the concomitant influence of these factors on changes in the left ventricular mass after renal transplantation.Methods: Twenty-four-hour urinary sodium excretion, glomerular filtration rate (isotopic clearance), and left ventricular mass (echocardiography) assessment were done in 165 renal transplant patients during the first year and after a follow-up of 3 years after renal transplantation.Results: At follow-up, therapy of hypertension was associated with normalization of blood pressure in 64% and a decrease in the prevalence of left ventricular hypertrophy from 66% to 56%. At baseline and follow-up, systolic blood pressure, sodium intake, and serum uric acid emerged as independent and significant determinants of the final left ventricular mass index. When the population was divided according to sex-specific tertiles of the final 24-hr urinary sodium excretion, the relationship between change in serum uric acid during follow-up, final left ventricular mass index, and final glomerular filtration rate was significant only on the highest tertile of 24-hr urinary sodium excretion.Conclusion: The decrease in the prevalence of left ventricular hypertrophy after renal transplantation is blunted by high sodium intake. Persistence of the left ventricular hypertrophy may result from the combined adverse influences of excessive dietary sodium intake and increased serum uric acid during follow-up despite pharmacological control of blood pressure.
Published: 2014
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9. Exogenous thyrotropin improves renal function in euthyroid patients, while serum creatinine levels are increased in hypothyroidism

Author: Àngel Argilés, Flore Duranton, Antoine Avignon, Patrick Faurous, Emmanuel Deshayes, Georges Mourad, Anouchka Lacoste, and Jean Ribstein
Subjects: endocrine system, medicine.medical_specialty, endocrine system diseases, Original Contributions, medicine.medical_treatment, Thyrotropin, Renal function, chemistry.chemical_compound, Hypothyroidism, Internal medicine, Medicine, Euthyroid, Transplantation, Creatinine, business.industry, Thyroidectomy, Original Articles, Peripheral, Thyroxine, Endocrinology, chemistry, Nephrology, Thyroid hormones, Sufficient time, business, hormones, hormone substitutes, and hormone antagonists, Glomerular Filtration Rate, Hormone
Abstract: Background. There is evidence showing that the hypothyroid state results in increased serum creatinine levels. However, whether this is only due to the peripheral thyroid hormones or if thyroid-stimulating hormone (TSH) is also involved is not known. Methods. Serum creatinine levels and estimated glomerular filtration rate (eGFR) were assessed in thyroidectomized patients with varying thyroid hormones and TSH levels. Blood samples from Group 1 (21 patients) were obtained 1 month after complete thyroidectomy, while under a hypothyroid state (t1) and a sufficient time after thyroid hormones initiation (euthyroid state, t2). Group 2 (20 euthyroid patients) were sampled after recombinant human thyrotropin injections (rhTSH, t1) and later after rhTSH extinction (t2). Results. In Group 1, serum creatinine levels decreased after correction of hypothyroidism (85.3 ± 4.3 versus 78.0 ± 3.9 μmol/L; P = 0.04). In Group 2, serum creatinine levels increased after rhTSH withdrawal (70.6 ± 5.7 μmol/L versus 76.5 ± 5.8 μmol/L; P = 0.007). Between t1 and t2, eGFR varied accordingly [Group 1, 71.7 ± 3.5 versus 81.2 ± 4.5 mL/min/1.73 m² (P = 0.02); Group 2, 97.7 ± 7.4 versus 87.5 ± 5.9 (P = 0.007)]. The changes in TSH and eGFR following supplementation with thyroxine were significantly correlated (r =�0.6, P = 0.0041). Conclusions. Iatrogenic hypothyroidism significantly increases serum creatinine and reversibly impairs eGFR, while treatment with rhTSH enhances renal function in euthyroid patients, supporting the existence of an influence of TSH level on renal function. The mechanisms by which peripheral thyroid hormones and TSH influence GFR need to be identified in physiology-orientated studies.
Published: 2013
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10. Auteurs

Author: Jean-Yves, Artigou, Jean-Jacques, Monsuez, Bernard, Bauduceau, Jacques, Blacher, Didier, Carrié, Ariel, Cohen, Martine, Gilard, Albert, Hagège, Sébastien, Hascoet, Richard, Isnard, Bernard, Iung, Yves, Juillière, Philippe, Lechat, Antoine, Leenhardt, Damien, Metz, Emmanuel, Messas, Jean-François, Obadia, Florence, Pinet, Raymond, Roudaut, Éric, Abergel, Saroumadi, Adavane-Scheuble, Salma, Adham, Julien, Adjedj, Bernard, Albat, Vincent, Algalarrondo, Véronique, Alibert, Sophie, Allepaerts, Pierre, Alric, Nicolas, Amabile, Laurence, Amar, Pascal, Amedro, Yann, Ancedy, Jean-Noël, Andarelli, Clémentine, André, Ramaroson, Andriantsitohaina, Denis, Angoulvant, Frédéric, Anselme, Hélène, Ansquer, Jean-Baptiste, Anzouan-Kackou, Aïcha, Aouad, Florence, Arnoult, Nicolas, Arribard, André, Atallah, Pierre, Aubry, Jean-François, Aupetit, Marie, Aymami, Armand, Aymard, Michel, Azizi, Dominique, Babuty, Magnus, Bäck, Jean-Philippe, Baguet, Fanny, Bajolle, Stéphanie, Baron, Stéphanie, Barrère-Lemaire, Alban-Elouen, Baruteau, Nils, Basillais, Alberto, Battaglia, Clément, Batteux, Florence, Beauvais, Pierrick, Bedouch, Theodora, Bejan-Angoulvant, Hasnaa, Belghiti, Reda, Belhaj Soulami, Emre, Belli, Sabrina, Ben Ahmed, Nesma, Bendagha, Myriam, Bensemlali, Alain, Berdeaux, Claire, Bertail-Galoin, Emmanuelle, Berthelot, Francis, Bessière, Isabelle, Bidaud, Loïc, Bière, Nicolas, Bihry, Jean-Pierre, Binon, Annouk, Bisdorff-Bresson, Arnaud, Bisson, Franck, Boccara, Olivia, Boccara, Thomas, Bochaton, Diane, Bodez, Angèle, Boet, Yohann, Bohbot, Catherine, Boileau, Laurent, Bonello, Éric, Bonnefoy, Lyse, Bordier, Jacques, Boschat, Gilles, Bosser, Béatrice, Bouhanick, Sarrah, Boukthir, Claire, Bouleti, Karl, Bounader, Pierre, Bourgoin, Pierre, Boutouyrie, Hélène, Bouvaist, Ebba, Brakenhielm, Philippe, Brenot, François, Brigadeau, Richard, Brion, Éric, Brochet, Amaury, Broussier, Sok-Sithikun, Bun, Alessandra, Bura-Riviere, David, Calvet, Ludovic, Canaud, Florence, Canoui-Poitrine, François, Carré, Vincent, Cattoir, Guillaume, Cayla, Pascal, Challande, Stéphane, Champiat, Alain, Chantepie, Bernard, Chanu, Sandrine, Charpentier, Philippe, Charron, Marion, Chauvet-Droit, Michel, Chauvin, Charles, Cheng, Mohamed, Chettibi, Philippe, Chevalier, Hélène, Chiavelli, Sidney, Chocron, Caroline, Chopinet-Degrugillier, Alexandre, Cinaud, Vittorio, Civelli, Nicolas, Clémenty, Alexandre, Cochet, Sarah, Cohen, Alain, Cohen-Solal, Jean-Philippe, Collet, Nicolas, Combes, Xavier, Copie, Hervé, Corbineau, Mihaela, Cordeanu, Bertrand, Cormier, Erika, Cornu, Yves, Cottin, Pierre-Yves, Courand, Jean-Luc, Cracowski, Antoine, Cremer, Bertrand, Crozatier, Caroline, Cueff, Fabio, Cuttone, Marie-Pia, d'Ortho, Antoine, Da Costa, Thibaud, Damy, Christian, De Chillou, Pascal, De Groote, la Villéon Grégoire, De, Pascal, Defaye, Jean-Claude, Deharo, François, Delahaye, Xavier, Delavenne, Claude, Delcayre, Antoine, Delinière, Clément, Delmas, Jean-Guillaume, Delpey, Pascal, Delsart, Isabelle, Denjoy, Thierry, Denolle, Jean-Pol, Depoix, François, Derimay, Geneviève, Derumeaux, Michel, Desnos, Jean-François, Deux, Isabelle, Di Centa, Sylvie, Di Filippo, Romain, Didier, Marina, Dijos, Jean-Guillaume, Dillinger, Marie-Lou, Dinet, Olivia, Domanski, Valérie, Domigo, Erwan, Donal, Hervé, Douard, Caroline, Dourmap, Denis, Duboc, Émilie, Dubois-Deruy, Olivier, Dubourg, Virginie, Dufrost, Yves, Dulac, Patrick, Dupouy, Xavier, Duval, Stéphane, Ederhy, Fedoua, El Louali, Meyer, Elbaz, Ludivine, Eliahou, Joseph, Emmerich, Laura, Ernande, Fabrice, Extramiana, Elie, Fadel, Laurent, Fauchier, Jean-Pierre, Fauvel, Antoine, Fayol, Jean-Luc, Fellahi, Émile, Ferrari, Marc, Ferrini, Marie, Fertin, Pierre, Fesler, Gérard, Finet, Erwan, Flécher, David, Fouassier, Virginie, Fouilloux, Jean-Marc, Frapier, Alain, Furber, Sébastien, Gaertner, Vincent, Galand, Arnault, Galat, Michel, Galinier, Thomas, Gandet, Estelle, Gandjbakhch, Rania, Gargouri, Anne, Garnier, Jérôme, Garot, Gauthier, Garret, Arthur, Gavotto, Etienne, Gayat, Dominique, Germain, Pierre, Gibelin, Paule, Gimenez-Roqueplo Anne, François, Godart, François, Goehringer, Sylvie, Gonzalez, Francisco, Gonzalez-Barlatay, Philippe, Gosse, Guillaume, Goudot, Jean-Baptiste, Gourraud, Marielle, Gouton, Daniel, Grinberg, Robert, Grolleau-Raoux, Yves, Gruel, Etienne, Grunenwald, Laurence, Guédon-Moreau, Soulef, Guendouz, Pascal, Guéret, Patrice, Guérin, Loïc, Guillevin, Philippe, Guilpain, Aitor, Guitarte, Gilbert, Habib, Khaled, Hadeed, Philippe, Hainaut, Jean-Michel, Halimi, Xavier, Halna Du Fretay, Quentin, Hauet, Tristan, Hazelzet, Gérard, Helft, Daniel, Henrion, Patrick, Henry, Françoise, Hidden-Lucet, Dominique, Himbert, Bruno, Hoen, Ali, Houeijeh, Jean-Pierre, Houppe, Lucile, Houyel, Fabien, Huet, Justine, Hugon-Rodin, Marc, Humbert, Olivier, Huttin, Fabien, Hyafil, Jocelyn, Inamo, Pauline, Issaurat, Mélanie, Jeanmichel, Guillaume, Jondeau, Adrien, Joseph, Patrick, Jourdain, Xavier, Jouven, Laurent, Juillard, Jean-Michel, Juliard, Clément, Karsenty, Kelly Robert, G., Lina, Khider, Didier, Klug, Michel, Komajda, Claude, Kouakam, Serge, Kownator, Florence, Kyndt, Fabien, Labombarda, Louis, Labrousse, Alain, Lacampagne, Patrick, Lacolley, Philippe, Lacroix, Magalie, Ladouceur, Stéphane, Lafitte, Jérémy, Laïk, Marc, Laine, Olivier, Lairez, Nicolas, Lamblin, Steve, Lancel, Patrizio, Lancellotti, Thierry, Langanay, Emmanuel, Lansac, Pierre, Lantelme, Violaine, Laparra, François-Xavier, Lapebie, Anne-Laure, Laprérie, Jihed, Laribi, Gilles, Lascault, Gabriel, Laţcu Decebal, Benoît, Lattuca, Claude, Laurian, Daniela, Laux, Mathieu, Le Bloa, Emmanuel, Le Bret, Claude, Le Feuvre, Laurianne, Le Gloan, Jean-Yves, Le Heuzey, Jérôme, Le Pavec, Céleste, Le Roux, Thierry, Le Tourneau, Guillaume, Lebreton, Jean-Michel, Lecerf, Christophe, Leclercq, Thibault, Leclercq, Guillaume, Ledieu, Bruno, Lefort, Alain, Leguerrier, Bernard, Lelong, Hélène, Lelong, Valentine, Léopold, Antoine, Lepillier, Pascal, Leprince, Lionel, Leroux, Maurice, Levy, Thibault, Lhermusier, Pascal, Lim, Damien, Logeart, Gervaise, Loirand, Marilucy, Lopez-Sublet, Aurélien, Lorthioir, Philippe, Mabo, Anne-Laure, Madika, Isabelle, Magnin-Pouli, Isabelle, Mahe, Lorraine, Maitrot-Mantelet, Alice, Maltret, Elia, Mangoni Matteo, Nicolas, Mansencal, Jacques, Mansourati, Pascale, Maragnes, Bertrand, Marcheix, Stella, Marchetta, Sylvestre, Maréchaux, Ariane, Marelli, Alexandre, Maria, Eloi, Marijon, Christelle, Marquié, Carmen, Martinez M., Raphaël, Martins, Jean-Louis, Mas, Stefan, Matecki, Amel, Mathiron, Pierre, Mauran, Philippe, Maury, Alexandre, Mebazaa, Philippe, Ménasché, Nicolas, Meneveau, Jean-Jacques, Mercadier, Pietro, Mesirca, Anne, Messali, Alexandre, Métras, Olivier, Metton, Christophe, Meune, Takouhie, Mgrditchian, Olivier, Milleron, Sarah, Millot, Lucile, Miquerol, Patrick, Mismetti, Julia, Mitchell, Jean-Pierre, Monassier, Jean-Luc, Monin, Pierre-Emmanuel, Morange, Adrien, Moreau, Anne, Moreau De Bellaing, Meriem, Mostefa Kara, Pascal, Motreff, Basile, Mouhat, Manon, Moulis, Claire, Mounier-Vehier, Frédéric, Mouquet, Jean-Jacques, Mourad, Arnold, Munnich, Joël, Nargeot, Philippe, Nguyen, Pascal, Nhan, Robert, Nicodème, Sandro, Nini, Jacky, Nizard, Antoine, Noël, Emmanuel, Noly Pierre, Karine, Nubret, Silvia, Oghina, Jean-Pierre, Ollivier, Olivier, Ormezzano, Caroline, Ovaert, Michel, Ovize, Franck, Paganelli, Luc, Pasquié Jean, Dominique, Pavin, Bruno, Pavy, Olivier, Paziaud, Julien, Peltan, Mathieu, Pernot, Francis, Pesteil, Jérôme, Petit, Pierard Luc, A., Bertrand, Pierre, Olivier, Piot, Jérôme, Piquereau, Nicolas, Piriou, Geneviève, Plu Bureau, Hélène, Pluchart, Baptiste, Polin, Thibaut, Pommier, Margaux, Pontailler, Jean, Porterie, Charlotte, Potelle, Françoise, Pousset, Matteo, Pozzi, Vincent, Pradeau, Pascal, Priollet, Vincent, Probst, Fabrice, Prunier, Brigitte, Raccah-Tebeka, Marc, Radermecker, Véronique, Regnault, Matthieu, Revest, Jean, Ribstein, Marlène, Rio, Gilles, Rioufol, Luc, Rochette, Anne, Rollin, Mauro, Romano, Agnès, Rötig, François, Roubille, Gérald, Roul, Jean-Christian, Roussel, Matthieu, Roustit, Simon, Rouze, François, Rouzet, Frederic, Sacher, Audrey, Sagnard, Jane-Lise, Samuel, Nadir, Saoudi, Marc, Sapoval, Vincent, Sauzeau, Laurent, Savale, Jean-Marc, Sellal, Christine, Selton-Suty, Jean-Michel, Sénard, Pierre, Seners, Florence, Sens, Marie-France, Seronde, Ardalan, Sharifzadehgan, Georgios, Sideris, François, Silhol, Jean-Sébastien, Silvestre, Aïda, Soufiani, Laurie, Soulat-Dufour, Géraud, Souteyrand, Olivier, Steichen, Dominique, Stephan, Pierre, Suchon, Elodie, Surget, Pierre, Tattevin, Jean-Benoît, Thambo, Arthur, Thery, Hélène, Thibault, Aurélie, Thollet, Daniel, Thomas, Julie, Thomas-Chabaneix, Nicolas, Tiberghien, Jacques, Tomasi, Claire, Toquet, Angelo-Giovanni, Torrente, Guillaume, Treulet, Christophe, Tribouilloy, Jean-Noël, Trochu, Sarah, Tubiana, Annie, Turkieh, William, Uhlrich, Marina, Urena, Bernard, Vaisse, Alexandre, Vallée, Caroline, Vayne, Géraldine, Vedrenne, Vladimir, Veksler, Clément, Venner, Renée, Ventura-Clapier, Bruno, Vergès, Mathieu, Vergnat, Clémence, Vernay, Céline, Verstuyft, Emmanuelle, Vidal-Petiot, Stéphane, Vignes, Marc, Villaceque, Olivier, Villemain, Marie, Vincenti, Cécile, Vindis, Gaetano, Vitale, Jean-Jacques, Von Hunolstein, Pascal, Vouhé, Karim, Wahbi, Denis, Wahl, Xavier, Waintraub, Karine, Warin Fresse, Alexandra, Yannoutsos, Hermann, Yao, Samuel, Zarka, Michel, Zeitouni, Marianne, Zeller, Laetitia, Zerkowski, and Stéphane, Zuily
Published: 2020
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11. Primary sclerosing cholangitis: a new cause of distal renal tubular acidosis

Author: I. Szwarc, Àngel Argilés, Jean Ribstein, Georges-Philippe Pageaux, Jean-Emmanuel Serre, Valentin Goutaudier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Néphrologie Dialyse Saint Guilhem (NDSG), Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ), and Néphrologie Dialyse Saint Guilhem ( NDSG )
Subjects: medicine.medical_specialty, Pathology, Urinary system, 030232 urology & nephrology, distal renal tubular acidosis, Gastroenterology, Primary sclerosing cholangitis, Nephropathy, Renal tubular acidosis, 03 medical and health sciences, Rare Diseases, 0302 clinical medicine, Distal renal tubular acidosis, [ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology, Internal medicine, medicine, 030212 general & internal medicine, Transplantation, liver transplantation, business.industry, primary sclerosing cholangitis, Metabolic acidosis, Jaundice, medicine.disease, Hypokalemia, 3. Good health, Nephrology, medicine.symptom, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: International audience; We describe the first case of distal renal tubular acidosis (dRTA) associated with primary sclerosing cholangitis. A 26-year-old Lao-Thai male patient presented with severe jaundice, metabolic acidosis and hypokalaemia. He was diagnosed of dRTA. Liver transplantation resulted in correction of electrolyte disturbances and hyperbilirubinaemia. A fludrocortisone-furosemide test revealed normal urinary acidification, demonstrating no residual dRTA. This observation suggests that dRTA may be an early manifestation of bilirubin-associated nephropathy or the consequence of an immune mechanism.
Published: 2016
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12. Twenty-Four-Hour Blood Pressure Monitoring to Predict and Assess Impact of Renal Denervation: The DENERHTN Study (Renal Denervation for Hypertension)

Author: Marc Sapoval, Helena Pereira, Jean Ribstein, Pierre Lantelme, Claire Mounier-Vehier, Xavier Girerd, Patrick Rossignol, C. Dourmap, Philippe Gosse, Thierry Denolle, Michel Azizi, Pascal Delsart, Bernard Chamontin, Jean-Jacques Mourad, Faiez Zannad, Jean-Michel Halimi, Guillaume Bobrie, Gilles Chatellier, Olivier Ormezzano, B. Vaisse, Matthieu Monge, Emile Ferrari, Daniel Herpin, Pierre-Yves Courand, and Antoine Cremer
Subjects: Male, medicine.medical_specialty, Ambulatory blood pressure, Sympathetic Nervous System, Time Factors, Resistant hypertension, Blood Pressure, 030204 cardiovascular system & hematology, Kidney, 03 medical and health sciences, 0302 clinical medicine, Internal Medicine, Medicine, Humans, Blood pressure monitoring, Single-Blind Method, 030212 general & internal medicine, Prospective Studies, Sympathectomy, Antihypertensive Agents, Aged, Denervation, business.industry, Blood Pressure Monitoring, Ambulatory, Middle Aged, 3. Good health, Surgery, Circadian Rhythm, Blood pressure, Anesthesia, Hypertension, Catheter Ablation, Female, business, Follow-Up Studies
Abstract: The DENERHTN trial (Renal Denervation for Hypertension) confirmed the blood pressure (BP) lowering efficacy of renal denervation added to a standardized stepped-care antihypertensive treatment for resistant hypertension at 6 months. We report here the effect of denervation on 24-hour BP and its variability and look for parameters that predicted the BP response. Patients with resistant hypertension were randomly assigned to denervation plus stepped-care treatment or treatment alone (control). Average and standard deviation of 24-hour, daytime, and nighttime BP and the smoothness index were calculated on recordings performed at randomization and 6 months. Responders were defined as a 6-month 24-hour systolic BP reduction ≥20 mm Hg. Analyses were performed on the per-protocol population. The significantly greater BP reduction in the denervation group was associated with a higher smoothness index ( P =0.02). Variability of 24-hour, daytime, and nighttime BP did not change significantly from baseline to 6 months in both groups. The number of responders was greater in the denervation (20/44, 44.5%) than in the control group (11/53, 20.8%; P =0.01). In the discriminant analysis, baseline average nighttime systolic BP and standard deviation were significant predictors of the systolic BP response in the denervation group only, allowing adequate responder classification of 70% of the patients. Our results show that denervation lowers ambulatory BP homogeneously over 24 hours in patients with resistant hypertension and suggest that nighttime systolic BP and variability are predictors of the BP response to denervation. Clinical Trial Registration— URL: https://www.clinicaltrials.gov . Unique identifier: NCT01570777.
Published: 2016

13. Adherence to Antihypertensive Treatment and the Blood Pressure–Lowering Effects of Renal Denervation in the Renal Denervation for Hypertension (DENERHTN) Trial

Author: Michel Azizi, Helena Pereira, Idir Hamdidouche, Philippe Gosse, Matthieu Monge, Guillaume Bobrie, Pascal Delsart, Claire Mounier-Véhier, Pierre-Yves Courand, Pierre Lantelme, Thierry Denolle, Caroline Dourmap-Collas, Xavier Girerd, Jean Michel Halimi, Faiez Zannad, Olivier Ormezzano, Bernard Vaïsse, Daniel Herpin, Jean Ribstein, Bernard Chamontin, Jean-Jacques Mourad, Emile Ferrari, Pierre-François Plouin, Vincent Jullien, Marc Sapoval, Gilles Chatellier, L. Amar, A. Lorthioir, J.-Y. Pagny, G. Claisse, M. Midulla, R. Dauphin, J.P. Fauvel, O. Rouvière, A. Cremer, N. Grenier, Y. Lebras, H. Trillaud, J.F. Heautot, A. Larralde, F. Paillard, P. Cluzel, D. Rosenbaum, D. Alison, M. Claudon, B. Popovic, P. Rossignol, J.P. Baguet, F. Thony, J.M. Bartoli, J. Drouineau, P. Sosner, J.P. Tasu, S. Velasco, H. Vernhet-Kovacsik, B. Bouhanick, H. Rousseau, S. Le Jeune, M. Lopez-Sublet, L. Bellmann, V. Esnault, I. Durand-Zaleski, J.P. Beregi (chair), M. Lièvre, A. Persu, Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon
Subjects: Nervous system, Male, medicine.medical_specialty, Sympathetic nervous system, [SDV]Life Sciences [q-bio], Medication adherence, Blood Pressure, 030204 cardiovascular system & hematology, Kidney, Medication Adherence, 03 medical and health sciences, 0302 clinical medicine, Physiology (medical), medicine, Humans, 030212 general & internal medicine, Prospective Studies, Prospective cohort study, Antihypertensive Agents, ComputingMilieux_MISCELLANEOUS, Denervation, business.industry, Blood Pressure Determination, Blood Pressure Monitoring, Ambulatory, Middle Aged, 3. Good health, Surgery, medicine.anatomical_structure, Blood pressure, Treatment Outcome, Anesthesia, Hypertension, Female, Blood pressure lowering, Cardiology and Cardiovascular Medicine, business
Abstract: Background: The DENERHTN trial (Renal Denervation for Hypertension) confirmed the blood pressure–lowering efficacy of renal denervation added to a standardized stepped-care antihypertensive treatment for resistant hypertension at 6 months. We report the influence of adherence to antihypertensive treatment on blood pressure control. Methods: One hundred six patients with hypertension resistant to 4 weeks of treatment with indapamide 1.5 mg/d, ramipril 10 mg/d (or irbesartan 300 mg/d), and amlodipine 10 mg/d were randomly assigned to renal denervation plus standardized stepped-care antihypertensive treatment, or the same antihypertensive treatment alone. For standardized stepped-care antihypertensive treatment, spironolactone 25 mg/d, bisoprolol 10 mg/d, prazosin 5 mg/d, and rilmenidine 1 mg/d were sequentially added at monthly visits if home blood pressure was ≥135/85 mm Hg after randomization. We assessed adherence to antihypertensive treatment at 6 months by drug screening in urine/plasma samples from 85 patients. Results: The numbers of fully adherent (20/40 versus 21/45), partially nonadherent (13/40 versus 20/45), or completely nonadherent patients (7/40 versus 4/45) to antihypertensive treatment were not different in the renal denervation and the control groups, respectively ( P =0.3605). The difference in the change in daytime ambulatory systolic blood pressure from baseline to 6 months between the 2 groups was –6.7 mm Hg ( P =0.0461) in fully adherent and –7.8 mm Hg ( P =0.0996) in nonadherent (partially nonadherent plus completely nonadherent) patients. The between-patient variability of daytime ambulatory systolic blood pressure was greater for nonadherent than for fully adherent patients. Conclusions: In the DENERHTN trial, the prevalence of nonadherence to antihypertensive drugs at 6 months was high (≈50%) but not different in the renal denervation and control groups. Regardless of adherence to treatment, renal denervation plus standardized stepped-care antihypertensive treatment resulted in a greater decrease in blood pressure than standardized stepped-care antihypertensive treatment alone. Clinical Trial Registration: URL: http://www.clinicaltrials.gov . Unique identifier: NCT01570777.
Published: 2016
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14. Etanercept normalises left ventricular mass in patients with rheumatoid arthritis

Author: Pierre Fesler, Jacques Morel, Guilhem du Cailar, Vincent Daien, Jean-Paul Cristol, Jean Ribstein, Bernard Combe, Thibault Mura, Anne-Marie Dupuy, and Claire Daien
Subjects: Adult, medicine.medical_specialty, Necrosis, Immunology, Pulse Wave Analysis, Receptors, Tumor Necrosis Factor, General Biochemistry, Genetics and Molecular Biology, Etanercept, Arthritis, Rheumatoid, Cohort Studies, Vascular Stiffness, Rheumatology, Internal medicine, medicine, Humans, Immunology and Allergy, Pulse wave velocity, Aged, Tumor Necrosis Factor-alpha, business.industry, Isoxazoles, Middle Aged, medicine.disease, Connective tissue disease, Surgery, Sulfasalazine, Methotrexate, Treatment Outcome, Blood pressure, Echocardiography, Antirheumatic Agents, Immunoglobulin G, Rheumatoid arthritis, Arterial stiffness, Cardiology, Female, Hypertrophy, Left Ventricular, Tumor necrosis factor alpha, medicine.symptom, business, Leflunomide, medicine.drug
Abstract: BackgroundCardiovascular mortality is increased in patients with rheumatoid arthritis (RA). RA is associated with an increased left ventricular mass index (LVMI), a strong marker of cardiovascular mortality, and vessel abnormalities. Experimental studies have suggested that tumour necrosis factor α (TNFα) may induce LV hypertrophy.ObjectiveTo study the effect of medium-term (3- and 6-months) treatment with the TNFα inhibitor etanercept (ETN) and synthetic disease-modifying antirheumatic drugs (sDMARDs) on LV morphological features and arterial stiffness in patients with RA.MethodsConsecutive female patients with active RA requiring treatment with ETN (n=28) or sDMARDs (n=20) were included. Clinical and biological monitoring, echocardiography and pulse wave velocity (PWV) assessment were performed at inclusion and at 3 and 6 months after the start of treatment. Paired t tests and multivariate linear regression analysis were used.ResultsMean LVMI tended to be higher at baseline in the ETN group than in the sDMARD group (96.5±19.8 vs 84.3±26.8 g/m2; p=0.11 for the ETN and sDMARD groups, respectively). In patients with ETN treatment, mean LVMI was significantly decreased at 3 and 6 months (−6.3±7.6 and −14.2±9.3 g/m2; p2, respectively). Blood pressure (BP) and aortic PWV were not changed by either treatment.ConclusionsETN induced a significant decrease in LVMI with medium-term treatment with no change in BP or PWV. TNFα may be an important factor of LV hypertrophy, which may explain the benefit of TNF inhibitors on cardiovascular morbidity and mortality in RA. These results need to be confirmed by larger studies and with other TNF inhibitors.
Published: 2012
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15. Early detection of isolated left ventricular diastolic dysfunction in high-risk differentiated thyroid carcinoma patients on TSH-suppressive therapy

Author: Isabelle Raingeard, Mathieu Sardinoux, Jean Ribstein, Guilhem du Cailar, Véronique Taillard, C. Rugale, Pierre Fesler, Eric Renard, and Carole Oudot
Subjects: medicine.medical_specialty, Cardiac output, business.industry, Endocrinology, Diabetes and Metabolism, Thyroid, Diastole, medicine.disease, Asymptomatic, Endocrinology, medicine.anatomical_structure, Blood pressure, Internal medicine, Heart rate, Cardiology, Medicine, medicine.symptom, business, Prospective cohort study, Thyroid cancer
Abstract: Summary Objective L-Thyroxine-suppressive therapy benefits high-risk differentiated thyroid cancer patients by decreasing recurrence rates and cancer-related mortality. However, fully suppressed serum thyroid-stimulating hormone (TSH) implies a state of subclinical hyperthyroidism (SCH) with associated adverse cardiac effects. Because left ventricular (LV) diastolic dysfunction may be the first manifestation of more severe LV failure, and to balance the risks from thyroid cancer recurrence with risks of cardiac failure, the purpose of this study was to analyse new parameters of LV function in asymptomatic patients with exogenous SCH. Design Case–control study with 24 patients on TSH-suppressive therapy of short duration (≤4 years) after thyroid ablative therapy for differentiated thyroid carcinoma and 20 age- and sex-matched subjects. Measurements LV function [LV global strain and strain rate (SR) curves] was assessed by speckle tracking imaging echocardiography in each subject. Results Patients and controls do not differ in body mass index, systolic blood pressure and heart rate. No significant differences were observed in LV morphology (LV mass and relative wall thickness), cardiac output and parameters of LV systolic function between patients on suppressive therapy and controls. When compared with controls, patients with exogenous SCH had a significantly impaired longitudinal protodiastolic strain, SR and strain diastolic index but preserved radial strain and SR function. Conclusions In subjects with SCH at the early phase of TSH-suppressive therapy, evidence of isolated longitudinal LV diastolic dysfunction was observed, despite a normal LV morphology. Further prospective studies to clarify the prognosis of picking-up early diastolic dysfunction in asymptomatic patients are needed before serial measurements could be recommended.
Published: 2011
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16. Living Lab MACVIA Maladies chroniques

Author: Michel David, Pascal Demoly, Rodolphe Bourret, Christine Viarouge-Reunier, Mélanie Badin, François Roubille, Bernard Combe, C. Boegner, Jacques Morel, Jean Bousquet, Pierre Fesler, Marie-Christine Picot, Michel Dauzat, Claire Daien, Antoine Avignon, Jacques Mercier, S. Granier, Ariane Sultan, V. Attalin, Béatrice Lognos, Jean Ribstein, D. J. Costa, Jean-Luc Pasquié, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Service de Rhumatologie [CHU de Montpellier], CHU Montpellier, Institut de Génétique Moléculaire de Montpellier (IGMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Université de Montpellier (UM), Physiopathologie des adaptations cardiovasculaires à l'Exercice, Avignon Université (AU), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Caractéristiques féminines des dysfonctions des interfaces cardio-vasculaires (EA 2992), Université Montpellier 1 (UM1)-Université de Montpellier (UM), Département de Rhumatologie[Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Lapeyronie, Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), and Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Secondary prevention, medicine.medical_specialty, Patient care team, business.industry, [SDV]Life Sciences [q-bio], Primary health care, Public-Private Sector Partnership, General Medicine, 030204 cardiovascular system & hematology, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, Chronic disease, Living lab, Primary prevention, Family medicine, Medicine, 030212 general & internal medicine, Motor activity, business, ComputingMilieux_MISCELLANEOUS
Abstract: La Presse Medicale - In Press.Proof corrected by the author Available online since jeudi 15 octobre 2015
Published: 2015
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17. Le site de référence du Partenariat européen d’innovation pour un vieillissement actif et en bonne santé MACVIA-LR (contre les maladies chroniques pour un vieillissement en bonne santé en Languedoc-Roussillon)

Author: Miren David, Ariane Sultan, Guillaume Pandraud, Benoît G. Bardy, Jacques Morel, Giacomo Cavalli, Sylvain Jacquemin, Christine Rolland, Cyril Breuker, Philippe Boulet, Gregoire Mercier, Stéphane Bouly, Valérie Bruguière, Gwen Mathieu, Marc Meissonnier, Hervé Tassery, Vincent Marmelat, Michel Dauzat, Hubert Blain, Gérard Dray, Cyril Laurent, Christine Viarouge-Reunier, Marie Virginie Calmels, François Rivier, Gérard Dupeyron, Gérard Bourrel, Jacquie Berthe, Philippe Domy, Béatrice Lognos, Martine Aoustin, Davide Caimmi, Michel Kaczorek, Mélanie Badin, Pierre Nicolas, Alain Le Quellec, Sylvie Boichot, Vincent Le Moing, C. Boegner, Jérôme Fernandes, Michel Amouyal, Matthieu Desplan, Jean Paul Cristol, T. Camuzat, Karima Bakhti, Jean Michel Verdier, Paule Adnet, Christophe Jorgensen, Denis Sablot, Jean Ribstein, Henriette Dhivert-Donnadieu, Céline Vergne-Richard, Emilie Porte, Christine Azevedo, Isabelle Quéré, Dominique Jakovenko, Marion Gellerat-Rogier, Michel Tanfin, Karen Ritchie, Flavia Oana Coroian, Bernard Guillot, Fabrice Nouvel, J. Pelissier, Anna Bedbrook, Daniel Laune, Jean-Luc Bourrain, Yves Marie Pers, Jean Luc Savy, Chantal Marion, Cherif Heroum, Marianna Danko, Grégoire Vergotte, Françoise Radier-Pontal, Jean Luc Pasquié, Olivier Bénézet, Bernard Combe, Sylvain Richard, Liliane Landreau, Valérie Cros, Isabelle Rédini-Martinez, Emilie Viollet, David Guiraud, François Roubille, Jérôme Froger, Bertrand Coulet, Laurent Journot, Marie Suzanne Léglise, Sylvie Arnavieilhe, Isabel Tavares, Samir Jaber, Olivier Jonquet, David Morquin, Philippe Van de Perre, Roland Sicard, Raphaël Chiron, Vincent Tribout, Pierre Senesse, Xavier Quantin, Jacques Touchon, Kevin Mandrick, Alain Uziel, Vincent Bouix, Marie Christine Picot, Philippe Augé, Martine Lapierre, Antoine Avignon, Eric Pastor, Pascal Demoly, Kjerstin Torre, Jacques Mercier, Jean-Marie Robine, Dominique Larrey, D. J. Costa, Grégory Ninot, Laurent Schifano, Baya Soua, Anne Wojtusciszyn, Jean-Christophe Gris, Didier Delignières, Florence Gressard, Marie Pierre Pasdelou, Fabienne Portejoie, Michel Mondain, Philippe Nérin, Olivier Hantkié, Xavier Bobia, Delphine Paccard, Pierre Géraud Claret, Maxime Villiet, Jacques Burille, Christian Hérisson, Guillaume Tallon, V. Attalin, Jean Emmanuel de la Coussaye, William Camu, Didier Hoa, Chokri Boubakri, Jacques Reynes, Michel Enjalbert, Pascal Kouyoumdjian, Anthony Gellis, Jean Marc Lussert, Jean Philippe Pin, Christian Bourquin, Jean-Marc Lemaitre, Rodolphe Bourret, Isabelle Laffont, Claudine Berr, Marie Christine Courrouy-Michel, Nicolas Giraudeau, Trias Asteriou, Catherine Leblond, Cyril Meunier, Sylvain Lehmann, M. Nogues, Denise Strubel, Raul Punta-Morales, Alain Makinson, Jacques Bringer, Stéphane Perrey, Nathalie Pinto, Yannick Stephan, Charles Fattal, Jean Marc Davy, Arnaud Bourdin, Emilie Royère, Arnaud Dupeyron, Claire Daien, François Vialla, Frédéric Viart, Joël Bockaert, Arnaud Yves Goucham, Pierre Aubas, Huei Yune Bonnin, Fares Gouzi, Véronique Carre, Nicolas Best, Jean Pierre Riso, Jérome Cottalorda, Max Villain, Philippe Dauenhauer, Patrick Messner, Amélie Matheron, Claude Jeandel, Roxana Taddei-Ologeanu, Bernard Alomène, Sylvie Albert, Stéphane Cade, Gérard Canovas, Pauline Coignard, Karine Patte, Sofiane Ramdani, Frédéric Abecassis, Maurice Hayot, Marc Ychou, Anne Laure Coupet, Nathalie Raffort, D. Heve, Philippe Gabrion, Pierre Mares, Pierre Labauge, Marie Pierre Battesti, Denis Mottet, Philippe Fraisse, Jean Bousquet, Jean Louis Pujol, Emilie Galano, Pierre Fesler, Vincent Dufour, Gregory Baptista, Pierre Louis Bernard, Mireille Fouletier, Pierre Dujol, Xavier Vasquez, Jean Paul Ortiz, Pierre Martin-Gousset, Philippe Courtet, Oude Engberink, Valérie Handweiler, S. Granier, Laurence Vian, Françoise Leclercq, Frédéric Cuisinier, Pierre Costa, Guillaume Cayla, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Nîmes (CHRU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Département d'anesthésie-réanimation[Montpellier], Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [Montpellier], Centre Hospitalier Régional Universitaire de Nîmes (CHRU Nîmes), Caractéristiques féminines des dysfonctions des interfaces cardio-vasculaires (EA 2992), Université Montpellier 1 (UM1)-Université de Montpellier (UM), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Department of Geriatrics - Efficiency and Deficiency Laboratory, Hadassah Hebrew University Medical Center [Jerusalem], IMT - MINES ALES (IMT - MINES ALES), Institut Mines-Télécom [Paris] (IMT), Département de Biostatistiques, Agence Régionale de Santé Languedoc Roussillon (ARS), Institut de Recherche en Infectiologie de Montpellier (IRIM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Roche Pharma Research and Early Development [Basel] (pRED), F. Hoffmann-La Roche [Basel], Service de gynécologie-obstétrique, Mécanismes adaptatifs : des organismes aux communautés (MAOAC), Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF)-Muséum national d'Histoire naturelle (MNHN), Laboratoire de Géochimie Isotopique Environnementale (GIS) / Université de Nîmes (GIS), Université de Nîmes (UNIMES)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Genre (LARHRA GENRE), LAboratoire de Recherche Historique Rhône-Alpes - UMR5190 (LARHRA), Centre National de la Recherche Scientifique (CNRS)-Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université de Lyon-Université Lumière - Lyon 2 (UL2)-École normale supérieure - Lyon (ENS Lyon)-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université de Lyon-Université Lumière - Lyon 2 (UL2)-École normale supérieure - Lyon (ENS Lyon)-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Grenoble Alpes (UGA), Département de Médecine générale, Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Control of Artificial Movement and Intuitive Neuroprosthesis (CAMIN), Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier (LIRMM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Département de médecine générale, Université de Montpellier (UM), Euromov (EuroMov), Centre Européen de Réalité Virtuelle (CERV), École Nationale d'Ingénieurs de Brest (ENIB), Laboratoire de Mathématiques Blaise Pascal (LMBP), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Centre National de la Recherche Scientifique (CNRS), Pathologies du système nerveux : recherche épidémiologique et clinique, Université Montpellier 1 (UM1)-IFR76-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Génomique Fonctionnelle (IGF), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), CERFRANCE Nord Est - Ile de France, Réseau de Vigilance en Dermato-Allergologie - Groupe d'Etudes et de Recherches en DERmato-Allergologie (Revidal-Gerda), Réseau de Vigilance en Dermato-Allergologie (Revidal), Centre Mutualiste de Rééducation et de Réadaptation Fonctionnelles de KERPAPE [Ploemeur] (CMRRF), Centre Mutualiste de Rééducation et de Réadaptation Fonctionnelles de Kerpape, Laboratoire de Bioingénierie et NanoSciences (LBN), Institut de Génétique Moléculaire de Montpellier (IGMM), Dynamique des capacités humaines et des conduites de santé (EPSYLON), Université Montpellier 1 (UM1)-Université Paul-Valéry - Montpellier 3 (UM3)-Université de Montpellier (UM), Laboratory of Cardio-Vascular Physiology (LCVP), Université Montpellier 1 (UM1), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de Rééducation et Réadaptation Neuro Orthopédique [Nîmes] (Pôle NACRRE), Hôpital Universitaire Carémeau [Nîmes], Centre Mutualiste de Réeducation Neurologique Propara (PROPARA), Languedoc Mutualité, Oc Santé Montpellier, Artificial movement and gait restoration (DEMAR), Unité de Rééducation Neurologique, Centre Hélio-Marin CHU Nîmes, Department de Dermatologie, Médecine physique et de réadaptation, Hôpital Lapeyronie [Montpellier] (CHU), Institut de Génomique Fonctionnelle - Montpellier GenomiX (IGF MGX), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Service de Chirurgie Orthopédique, Département de neurologie [Montpellier], Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [Montpellier]-Université de Montpellier (UM), Centre Bouffard-Vercelli, Laboratoire de Mécanique et Technologie (LMT), École normale supérieure - Cachan (ENS Cachan)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Plateforme de Protéomique Clinique, CHU Saint-Eloi, Recherches Translationnelles sur le VIH et les maladies infectieuses (TransVIHMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Recherche pour le Développement (IRD)-Université Montpellier 1 (UM1)-Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Universtié Yaoundé 1 [Cameroun]-Université de Montpellier (UM), Département Conception et conduite des véhicules Aéronautiques et Spatiaux (DCAS), Institut Supérieur de l'Aéronautique et de l'Espace (ISAE-SUPAERO), Lab-STICC_TB_CID_TOMS, Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance (Lab-STICC), École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Télécom Bretagne-Institut Brestois du Numérique et des Mathématiques (IBNM), Université de Brest (UBO)-Université européenne de Bretagne - European University of Brittany (UEB)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS)-École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Télécom Bretagne-Institut Brestois du Numérique et des Mathématiques (IBNM), Université de Brest (UBO)-Université européenne de Bretagne - European University of Brittany (UEB)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de recherche souterrain de Meuse/Haute-Marne, Agence Nationale de gestion des Déchets Radioactifs, Aix-Marseille Université - Faculté des Sciences du Sport (AMU FSS), Aix Marseille Université (AMU), HORIBA Medical (HORIBA ABX SAS), HORIBA Scientific [France], Unité Mathématique, Informatique et Génome (MIG), Institut National de la Recherche Agronomique (INRA), Interactions, Corpus, Apprentissages, Représentations (ICAR), École normale supérieure - Lyon (ENS Lyon)-Université Lumière - Lyon 2 (UL2)-INRP-Ecole Normale Supérieure Lettres et Sciences Humaines-Centre National de la Recherche Scientifique (CNRS), Unité clinique d'Immuno-Rhumatologie & Thérapeutique des maladies ostéo-articulaires, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Lapeyronie, Institut de Chimie des Substances Naturelles (ICSN), Centre National de la Recherche Scientifique (CNRS), UNICANCER - Institut régional du Cancer [Montpellier] (ICM), CRLCC Val d'Aurelle - Paul Lamarque, Biocommunication en Cardio-Métabolique (BC2M), Neuropsychiatrie : recherche épidémiologique et clinique, Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Département d'oncologie médicale et digestive, Centre de cancérologie Val d'Aurelle, Complexité, Innovation, Activités Motrices et Sportives (CIAMS), Université d'Orléans (UO)-Université Paris-Sud - Paris 11 (UP11), Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] (CAPS), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM), Physiopathologie et thérapie des déficits sensoriels et moteurs, Université Montpellier 2 - Sciences et Techniques (UM2)-IFR76-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de recherche et de Diagnostic sur le Sida (CeDreS), CHU Treichville, Interaction entre Systèmes Protéiques et Différenciation dans la Cellule Tumorale (ISPDCT), Université de la Méditerranée - Aix-Marseille 2-Centre National de la Recherche Scientifique (CNRS), Dynamiques du droit (DD), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Centre National de la Recherche Scientifique (CNRS), Centre de pharmacologie et innovation dans le diabète (CPID), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Centre National de la Recherche Scientifique (CNRS), Recherche en épidémiologie et biostatistique, Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ), Université Montpellier 1 ( UM1 ) -Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Hôpital Gui de Chauliac, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] ( PhyMedExp ), Centre National de la Recherche Scientifique ( CNRS ) -Université de Montpellier ( UM ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), IMT - Mines Alès Ecole Mines - Télécom ( IMT - MINES ALES ), Agence Régionale de Santé Languedoc Roussillon ( ARS ), Institut de Recherche en Infectiologie de Montpellier ( IRIM ), Centre National de la Recherche Scientifique ( CNRS ) -Université de Montpellier ( UM ), Roche Pharma Research and Early Development [Basel] ( pRED ), Centre Hospitalier Régional Universitaire de Nîmes ( CHRU Nîmes ), Mécanismes adaptatifs : des organismes aux communautés ( MAOAC ), Muséum National d'Histoire Naturelle ( MNHN ) -Collège de France ( CdF ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Géochimie Isotopique Environnementale (GIS) / Université de Nîmes ( GIS ), Centre National de la Recherche Scientifique ( CNRS ) -Université de Nîmes ( UNIMES ), Institut de recherche en cancérologie de Montpellier ( IRCM ), Université Montpellier 1 ( UM1 ) -CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Montpellier ( UM ), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon ( MACVIA-LR ), Université Montpellier 1 ( UM1 ) -World Health Organization ( WHO/OMS ) -Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre Hospitalier Régional Universitaire de Nîmes ( CHRU Nîmes ) -Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ) -European Innovation Partnership on Active and Healthy Ageing Reference Site, Agence Nationale de Sécurité Sanitaire, de l'Alimentation, de l'environnement et du Travail ( ANSES ), ANSES, Genre ( LARHRA GENRE ), LAboratoire de Recherche Historique Rhône-Alpes - UMR5190 ( LARHRA ), Centre National de la Recherche Scientifique ( CNRS ) -Université Jean Moulin - Lyon III-Université Lumière - Lyon 2 ( UL2 ) -École normale supérieure - Lyon ( ENS Lyon ) -Université Pierre Mendès France - Grenoble 2 ( UPMF ) -Université Grenoble Alpes ( UGA ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Jean Moulin - Lyon III-Université Lumière - Lyon 2 ( UL2 ) -École normale supérieure - Lyon ( ENS Lyon ) -Université Pierre Mendès France - Grenoble 2 ( UPMF ) -Université Grenoble Alpes ( UGA ), Université Montpellier 1 ( UM1 ), Artificial movement and gait restoration ( DEMAR ), Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier ( LIRMM ), Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ) -Inria Sophia Antipolis - Méditerranée ( CRISAM ), Institut National de Recherche en Informatique et en Automatique ( Inria ) -Institut National de Recherche en Informatique et en Automatique ( Inria ), Université de Montpellier ( UM ), Euromov ( EuroMov ), Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Montpellier ( UM ), Centre Européen de Réalité Virtuelle ( CERV ), École Nationale d'Ingénieurs de Brest ( ENIB ), Laboratoire de Mathématiques Blaise Pascal ( LMBP ), Université Blaise Pascal - Clermont-Ferrand 2 ( UBP ) -Centre National de la Recherche Scientifique ( CNRS ), Université Montpellier 1 ( UM1 ) -IFR76-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Institut de Génomique Fonctionnelle ( IGF ), Centre National de la Recherche Scientifique ( CNRS ) -Université Montpellier 2 - Sciences et Techniques ( UM2 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Montpellier 1 ( UM1 ) -Université de Montpellier ( UM ), Réseau de Vigilance en Dermato-Allergologie - Groupe d'Etudes et de Recherches en DERmato-Allergologie ( Revidal-Gerda ), Réseau de Vigilance en Dermato-Allergologie ( Revidal ), Centre Mutualiste de Rééducation et de Réadaptation Fonctionnelles de KERPAPE [Ploemeur] ( CMRRF ), Laboratoire de Bioingénierie et NanoScience-UM, Université Montpellier 1 ( UM1 ) -Université de Montpellier ( UM ), Institut de Génétique Moléculaire de Montpellier ( IGMM ), Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ), Dynamique des capacités humaines et des conduites de santé ( EPSYLON ), Université Paul-Valéry - Montpellier 3 ( UM3 ) -Université Jean Monnet [Saint-Étienne] ( UJM ) -Université Montpellier 1 ( UM1 ) -Université de Montpellier ( UM ), Laboratory of Cardio-Vascular Physiology ( LCVP ), Institut Pierre Louis d'Epidémiologie et de Santé Publique ( iPLESP ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Département de Rééducation et Réadaptation Neuro Orthopédique [Nîmes] ( Pôle NACRRE ), Centre Mutualiste de Réeducation Neurologique Propara ( PROPARA ), Hôpital Lapeyronie [Montpellier] ( CHU ), Institut de Génomique Fonctionnelle - Montpellier GenomiX ( IGF MGX ), Laboratoire de Mécanique et Technologie ( LMT ), École normale supérieure - Cachan ( ENS Cachan ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Centre National de la Recherche Scientifique ( CNRS ), CHU Saint-Eloi-Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Montpellier ( UM ), Recherches Translationnelles sur le VIH et les maladies infectieuses ( TransVIHMI ), Université Montpellier 1 ( UM1 ) -Université Cheikh Anta Diop ( UCAD ) -Universtié Yaoundé 1 (Cameroun)-Université de Montpellier ( UM ), Département Conception et conduite des véhicules Aéronautiques et Spatiaux ( DCAS ), Institut Supérieur de l'Aéronautique et de l'Espace ( ISAE-SUPAERO ), Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance ( Lab-STICC ), École Nationale d'Ingénieurs de Brest ( ENIB ) -Université de Bretagne Sud ( UBS ) -Université de Brest ( UBO ) -Télécom Bretagne-Institut Brestois du Numérique et des Mathématiques ( IBNM ), Université de Brest ( UBO ) -Université européenne de Bretagne ( UEB ) -ENSTA Bretagne-Institut Mines-Télécom [Paris]-Centre National de la Recherche Scientifique ( CNRS ) -École Nationale d'Ingénieurs de Brest ( ENIB ) -Université de Bretagne Sud ( UBS ) -Université de Brest ( UBO ) -Télécom Bretagne-Institut Brestois du Numérique et des Mathématiques ( IBNM ), Université de Brest ( UBO ) -Université européenne de Bretagne ( UEB ) -ENSTA Bretagne-Institut Mines-Télécom [Paris]-Centre National de la Recherche Scientifique ( CNRS ), Aix-Marseille Université - Faculté des Sciences du Sport ( AMU FSS ), Aix Marseille Université ( AMU ), HORIBA Medical ( HORIBA ABX SAS ), Unité Mathématique, Informatique et Génome ( MIG ), Institut National de la Recherche Agronomique ( INRA ), Interactions, Corpus, Apprentissages, Représentations ( ICAR ), École normale supérieure - Lyon ( ENS Lyon ) -Université Lumière - Lyon 2 ( UL2 ) -INRP-Ecole Normale Supérieure Lettres et Sciences Humaines-Centre National de la Recherche Scientifique ( CNRS ), Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Hôpital Lapeyronie, Institut de Chimie des Substances Naturelles ( ICSN ), Centre National de la Recherche Scientifique ( CNRS ), UNICANCER - Institut régional du Cancer [Montpellier] ( ICM ), Efficience Déficience Motrice [Montpellier] ( EDM ), Centre de pharmacologie et innovation dans le diabète ( CPID ), Université Montpellier 1 ( UM1 ) -Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Centre National de la Recherche Scientifique ( CNRS ), Complexité, Innovation, Activités Motrices et Sportives ( CIAMS ), Université Paris-Sud - Paris 11 ( UP11 ) -Université d'Orléans ( UO ), Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] ( CAPS ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université Montpellier 2 - Sciences et Techniques ( UM2 ) -IFR76-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre de recherche et de Diagnostic sur le Sida ( CeDreS ), Interaction entre Systèmes Protéiques et Différenciation dans la Cellule Tumorale ( ISPDCT ), Université de la Méditerranée - Aix-Marseille 2-Centre National de la Recherche Scientifique ( CNRS ), Dynamiques du droit ( DD ), Centre National de la Recherche Scientifique ( CNRS ) -Université Montpellier 1 ( UM1 ) -Université de Montpellier ( UM ), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), CERMES3 - Centre de recherche Médecine, sciences, santé, santé mentale, société (CERMES3 - UMR 8211 / U988 / UM 7), École des hautes études en sciences sociales (EHESS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Génie Informatique et Ingénierie de Production (LGI2P), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Agence Régionale de la Santé (ARS), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Pierre Mendès France - Grenoble 2 (UPMF)-École normale supérieure - Lyon (ENS Lyon)-Université Lumière - Lyon 2 (UL2)-Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Université Pierre Mendès France - Grenoble 2 (UPMF)-École normale supérieure - Lyon (ENS Lyon)-Université Lumière - Lyon 2 (UL2)-Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Inria Sophia Antipolis - Méditerranée (CRISAM), Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Université Paul-Valéry - Montpellier 3 (UPVM)-Université de Montpellier (UM), Hôpital Universitaire Carémeau [Nîmes] (CHU Nîmes), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Oc Santé [Montpellier], Interactive Digital Humans (IDH), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Hôpital Gui de Chauliac [Montpellier]-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Université de Montpellier (UM), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques er émergentes (TransVIHMI), Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Institut de Recherche pour le Développement (IRD)-Université de Yaoundé I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Université Montpellier 1 (UM1), Service de Rhumatologie [CHRU Montpellier], École normale supérieure - Lyon (ENS Lyon)-Université Lumière - Lyon 2 (UL2)-INRP-Ecole Normale Supérieure Lettres et Sciences Humaines (ENS LSH)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Institut du Cancer de Montpellier (ICM), Université Paris-Sud - Paris 11 (UP11)-Université d'Orléans (UO), Centre de recherche et de Diagnostic sur le Sida [Abidjan, Côte d'Ivoire] (CeDreS), Centre Hospitalier Universitaire de Treichville [Abidjan, Côte d'Ivoire] (CHU de Treichville), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université Montpellier 1 (UM1), Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1), Muséum national d'Histoire naturelle (MNHN)-Collège de France (CdF)-Centre National de la Recherche Scientifique (CNRS), and CRLCC Val d'Aurelle - Paul Lamarque-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Aging, [ SDV ] Life Sciences [q-bio], business.industry, [SDV]Life Sciences [q-bio], General Medicine, MESH: Accidental Falls, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, [ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology, Medicine, 030211 gastroenterology & hepatology, Accidental Falls, MESH: Aging, 030212 general & internal medicine, business, Humanities, ComputingMilieux_MISCELLANEOUS, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: International audience; Le site de référence du Partenariat européen d'innovation pour un vieillissement actif et en bonne santé MACVIA-LR (contre les maladies chroniques pour un vieillissement en bonne santé en Languedoc-Roussillon)
Published: 2015
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18. [Living Lab MACVIA. Chronic diseases]

Author: Antoine, Avignon, Pierre, Fesler, Claire, Daien, David, Costa, Marie-Christine, Picot, François, Roubille, Ariane, Sultan, Christine, Viarouge-Reunier, Vincent, Attalin, Mélanie, Badin, Catherine, Boegner, Pascal, Demoly, Michel, Dauzat, Michel, David, Béatrice, Lognos, Jacques, Morel, Jean-Luc, Pasquié, Jean, Ribstein, Sophie, Granier, Bernard, Combe, Jacques, Mercier, Rodolphe, Bourret, and Jean, Bousquet
Subjects: Patient Care Team, Aging, Internet, Biomedical Research, Health Information Exchange, Primary Health Care, Delivery of Health Care, Integrated, Interprofessional Relations, Social Support, Health Promotion, Professional-Patient Relations, Motor Activity, Public-Private Sector Partnerships, Primary Prevention, Early Diagnosis, Rheumatic Diseases, Chronic Disease, Secondary Prevention, Electronic Health Records, Humans, France, Public Health, Hospitals, Teaching, Aged
Published: 2015

19. Hyperfiltration in Lean Essential Hypertension

Author: Albert Mimran, Jean Ribstein, Guilhem DuCailar, and Jean-Michel Halimi
Subjects: medicine.medical_specialty, business.industry, medicine, Essential hypertension, medicine.disease, Intensive care medicine, business
Published: 2015
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20. Pressure Dependence of Renal Hemodynamics and Function during Converting-Enzyme Inhibition in Congestive Heart Failure

Author: Dominique de Treglode, Jean Ribstein, and Albert Mimran
Subjects: medicine.medical_specialty, Enzyme inhibition, Text mining, business.industry, Internal medicine, Heart failure, medicine, Cardiology, Renal hemodynamics, Pressure dependence, business, medicine.disease, Function (biology)
Published: 2015
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21. CT-pro-AVP as a tool for assessment of intravascular volume depletion in severe hyponatremia

Author: Nils Kuster, Sébastien Jugant, Kada Klouche, Anne-Marie Dupuy, Delphine Buthiau, Delphine Daubin, Jean Ribstein, Jean-Paul Cristol, Marion Almeras, Guilaine Boursier, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Département d'hématologie biologique[Montpellier], Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-CHU Saint-Eloi, Université de Montpellier (UM), Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), and Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)
Subjects: Male, medicine.medical_specialty, Vasopressin, Clinical Biochemistry, Hypovolemia, Pilot Projects, Severity of Illness Index, Internal medicine, medicine, Intravascular volume status, Hospital discharge, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, ComputingMilieux_MISCELLANEOUS, Aged, Aged, 80 and over, Blood Volume, business.industry, General Medicine, Plasma levels, Middle Aged, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, medicine.disease, 3. Good health, Arginine Vasopressin, Anesthesia, Cardiology, Biomarker (medicine), Female, CT-pro-AVP, Intravascular volume depletion, medicine.symptom, Hyponatremia, business, Intravascular volume, Biomarkers, hormones, hormone substitutes, and hormone antagonists
Abstract: Assessment of volume status is essential to best manage hyponatremic patients but is not always accurate in clinical practice. The aim of this study was to evaluate the reliability of C-terminal portion of pro-arginine-vasopressin (CT-pro-AVP), a surrogate biomarker of vasopressin release, in assessing intravascular volume (IVV) depletion in hypoosmolar hyponatremic patients.Plasma CT-pro-AVP and urea-to-creatinine ratio (Ur/Cr) were performed in 131 hospitalized patients presenting chronic severe hypoosmolar hyponatremia. At hospital discharge, their IVV was evaluated regardless of CT-pro-AVP concentrations. All patients were then classified as decreased or as normal/expanded IVV group.Plasma CT-pro-AVP levels were higher in patients with decreased IVV (34.6 vs. 11.3 pmol/L, p0.001) and exhibited a reliable performance for assessment of decreased IVV (ROC AUC at 0.717 [95% CI 0.629-0.805]). The combination of CT-pro-AVP and Ur/Cr resulted in an improved ROC AUC up to 0.787 (95% CI 0.709-0.866).Our findings support the hypothesis that CT-pro-AVP plasma level may reflect IVV and would be a tool for its assessment. This performance has been magnified by its combination with Ur/Cr. A dual-marker strategy may help clinicians to optimize the management of severe hyponatremia especially in case of confusing clinical presentations.
Published: 2015
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22. Markers of bone remodeling are associated with arterial stiffness in renal transplanted subjects

Author: Nils Kuster, Anne-Marie Dupuy, Anne-Sophie Bargnoux, Jean Ribstein, F. Vetromile, Julie Barberet, Georges Mourad, Pierre Fesler, Jean-Paul Cristol, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Laboratoire de Biologie de la reproduction CECOS - [CHU de Dijon], Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Biocommunication en Cardio-Métabolique (BC2M), Université de Montpellier (UM), MORNET, Dominique, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Département de biochimie [Montpellier], Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Lapeyronie, Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), and Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)
Subjects: Fibroblast growth factor 23, Nephrology, Adult, Male, medicine.medical_specialty, Mean arterial pressure, 030232 urology & nephrology, 030204 cardiovascular system & hematology, Pulse Wave Analysis, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, Bone remodeling, 03 medical and health sciences, 0302 clinical medicine, Vascular Stiffness, Internal medicine, medicine, Humans, Arterial Pressure, Vitamin D, Pulse wave velocity, ComputingMilieux_MISCELLANEOUS, business.industry, Age Factors, Osteoprotegerin, Renal transplantation, Middle Aged, medicine.disease, [SDV.MHEP.UN] Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, Kidney Transplantation, Arterial stiffness, Transplantation, Femoral Artery, Fibroblast Growth Factor-23, Endocrinology, Blood pressure, Carotid Arteries, Cardiology, Kidney Failure, Chronic, Female, Bone Remodeling, business, Biomarkers, Glomerular Filtration Rate
Abstract: International audience; Background: Bone-vessel interaction in chronic renal failure remains poorly understood and could be driven by bone remodeling factors including osteoprotegerin (OPG), fibroblast growth factor 23 (FGF23), parathormone and vitamin D. Only few data are available in renal transplantation. The aim of this study was to investigate the relationship between bone remodeling factors and large artery function in renal transplant patients.Methods: 89 renal transplant patients were enrolled in this cross-sectional study. Carotid to femoral pulse wave velocity (PWV) and central augmentation index (AIx) were determined as an estimation of large artery function. Blood samples were collected for measurement of vascular risk markers. Independent predictors were identified by multivariate linear regression through backward feature selection using Akaike's information criteria.Results: At multivariate analysis, age (p < 0.001) and systolic arterial pressure (p = 0.003) were significantly associated with PWV but not AIx. In addition, both elevated blood concentrations of 1.25(OH)2 vitamin D (p = 0.013) and OPG (p = 0.047) were still significantly related to high PWV.Conclusions: These results underline that age and mean arterial pressure are the main determinants of PWV following renal transplantation. Among bone remodeling biomarkers, plasma OPG and active vitamin D were the strongest determinants of arterial stiffness.
Published: 2015
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23. Prise en charge de l’hypertension artérielle d’origine rénale

Author: Pierre Fesler and Jean Ribstein
Subjects: medicine.medical_specialty, Kidney, Proteinuria, business.industry, Urinary system, Renal function, General Medicine, medicine.disease, Nephropathy, Blood pressure, medicine.anatomical_structure, Internal medicine, Cardiology, Medicine, medicine.symptom, Salt intake, business, Kidney disease
Abstract: Assessment of every hypertensive patient must include the search for kidney disease, i.e. elevated serum creatinine and proteinuria. Antihypertensive therapy may attenuate both the risk of progression toward renal failure and the cardiovascular risk associated with chronic kidney disease, albeit the cause or the consequence of hypertension. Any alteration in renal function will promote salt-sensitivity of blood pressure and increase the deleterious effects of salt intake on target organ damage. The goal of antihypertensive therapy in patients with chronic kidney disease is first to reduce systolic blood pressure below 130 mmHg. The second goal is to lower urinary protein excretion to less than 0.5 g per day. The presence of proteinuria calls for blockers of the renin-angiotensin system among antihypertensive drugs. Global risk management (i.e. fighting tobacco, obesity, dyslipemia) will reduce the renal as well as the cardiovascular risk.
Published: 2006
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24. Hypotension orthostatique

Author: Jean Ribstein, Guilhem du Cailar, Jean-Michel Halimi, and Albert Mimran
Published: 2006
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25. Estimation of Renal Function in Subjects With Normal Serum Creatinine Levels: Influence of Age and Body Mass Index

Author: Jacobien C. Verhave, Pierre Fesler, Albert Mimran, Jean Ribstein, and Guilhem du Cailar
Subjects: Adult, Male, Nephrology, medicine.medical_specialty, Adolescent, Urology, Renal function, Comorbidity, Serum Creatinine Measurement, Kidney Function Tests, urologic and male genital diseases, Body Mass Index, Nephropathy, chemistry.chemical_compound, Picrates, Predictive Value of Tests, Internal medicine, Outpatients, Humans, Medicine, False Positive Reactions, Obesity, reproductive and urinary physiology, Aged, Aged, 80 and over, Creatinine, business.industry, Confounding, Age Factors, Confounding Factors, Epidemiologic, Middle Aged, medicine.disease, female genital diseases and pregnancy complications, Endocrinology, chemistry, Hypertension, Technetium Tc 99m Pentetate, Female, Kidney Diseases, Radiopharmaceuticals, business, Body mass index, Algorithms, Blood Chemical Analysis, Glomerular Filtration Rate, Kidney disease
Abstract: The Cockcroft-Gault (CG) and simplified Modification of Diet in Renal Disease (MDRD) formulas are the most widely used estimates of renal function. The influence of age and body mass index (BMI) on the performance of these equations was analyzed in 850 subjects with serum creatinine levels less than 1.5 mg/dL (133 micromol/L).Glomerular filtration rate (GFR) was measured as urinary clearance of continuously infused technetium Tc 99m-labeled diethylene triaminopentaacetic acid. Performance was assessed as bias, precision, and accuracy.In the total population, the CG and MDRD calculations based on enzymatic measurement of serum creatinine (which is constantly less than that obtained by using the alkaline picrate [Jaffé] method) significantly underestimated GFR by 4.9 and 12.4 mL/min/1.73 m2 (0.08 and 0.21 mL/s/1.73 m2), respectively. In patients 65 years and older, underestimation by means of the CG formula was enhanced, whereas that by means of the MDRD formula was blunted, compared with the group younger than 65 years (-11.3 versus -3.7 mL/min/1.73 m2 [-0.19 versus -0.06 mL/s/1.73 m2] for CG and -3.7 versus -14.0 mL/min/1.73 m2 [-0.06 versus -0.23 mL/s/1.73 m2] for MDRD). GFR was underestimated to a large extent by means of the MDRD equation irrespective of BMI. Conversely, the underestimation by means of the CG formula found in lean people (-13.0 mL/min/1.73 m2 [-0.22 mL/s/1.73 m2]) was blunted in overweight people (BMI, 25 to 30 kg/m2) and reversed to overestimation (+10.1 mL/min/1.73 m2 [+0.17 mL/s/1.73 m2]) in obese subjects (BMI30 kg/m2).As suggested by estimations obtained using enzymatic serum creatinine measurement, the MDRD equation may be the estimation of choice in elderly patients, whereas the CG estimate is preferable in subjects younger than 65 years. Nevertheless, when obesity is present, no reliable estimation can be obtained by using the CG or MDRD formula.
Published: 2005
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26. Relative Glomerular Hyperfiltration in Primary Aldosteronism

Author: Guilhem du Cailar, Jean Ribstein, Albert Mimran, and Pierre Fesler
Subjects: Adenoma, Adult, Male, medicine.medical_specialty, Renal glomerulus, Kidney Glomerulus, Renal function, Blood Pressure, Spironolactone, Essential hypertension, Renal Circulation, Renin-Angiotensin System, chemistry.chemical_compound, Primary aldosteronism, Internal medicine, Hyperaldosteronism, medicine, Humans, Aged, Mineralocorticoid Receptor Antagonists, Aldosterone, business.industry, General Medicine, Effective renal plasma flow, Middle Aged, medicine.disease, Adrenal Cortex Neoplasms, Endocrinology, chemistry, Nephrology, Albuminuria, Female, medicine.symptom, business, Glomerular hyperfiltration, Glomerular Filtration Rate
Abstract: Experimental and clinical data suggest that primary aldosteronism (PA) may be associated with cardiovascular hypertrophy and fibrosis, in part independent of the BP level. Whether PA may also result in specific deleterious effects on the kidneys was less studied. In 25 patients with tumoral PA, renal studies (urinary excretion of proteins, GFR, and effective renal plasma flow [ERPF], as clearances of technetium-labeled diethylene triaminopentaacetic acid and 131I-ortho iodohippurate, respectively) were performed both before and 6 mo after surgical cure. A control group consisting of patients with essential hypertension (EH) was studied before and after 6 mo of antihypertensive therapy. At baseline, PA and EH patients were similar with respect to demographic data, duration and level of hypertension, and GFR and ERPF. Urinary excretion of albumin and beta2 microglobulin were higher in PA than EH (88 +/- 26 versus 39 +/- 12 and 0.91 +/- 0.23 versus 0.26 +/- 0.19 mg/24 h, respectively; both P < 0.05). Adrenalectomy was followed by a decrease in arterial BP (by 28 +/- 3/13 +/- 2 mmHg), urinary excretion of albumin and beta2 microglobulin (by 48 +/- 19 and 0.53 +/- 0.21 mg/24 h, respectively), and GFR and ERPF (by 15 +/- 3 and 54 +/- 15 ml/min per 1.73 m(2), respectively). In EH, a similar decrease in pressure was associated with a decrease in albuminuria but no change in GFR or ERPF. In 17 of the 25 PA patients who received a 6-mo treatment of spironolactone, both GFR and ERPF decreased in parallel with BP, similar to what was observed after surgery. These data suggest that PA was associated with relative hyperfiltration, unmasked after suppression of aldosterone excess.
Published: 2005
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27. Efficacité et la tolérance de la lercanidipine ne sont pas liées à l'âge des patients hypertendus : étude AGATE

Author: Jean Ribstein, C. Scart Gres, L. Goullard, P. Poncelet, M. Bassous, and P. Clerson
Subjects: Gynecology, medicine.medical_specialty, business.industry, Lercanidipine, medicine, Dihydropyridine derivatives, Cardiology and Cardiovascular Medicine, business, Adrenal Cortex Diseases, medicine.drug
Abstract: Resume Les inhibiteurs calciques sont valides comme traitement de premiere intention de l'hypertension arterielle. Ils sont reputes plus efficaces et mieux toleres chez les patients âges. Le caractere hautement lipophile et vasoselectif de la lercanidipine lui confere une longue duree d'action et une meilleure tolerance. L'etude AGATE est une etude structuree de phase IV, ouverte, non randomisee, conduite chez des medecins generalistes en situation pragmatique. Elle etudie l'efficacite et la tolerance de la lercanidipine administree en monotherapie ou en add-on, a la dose de 10 a 20 mg/jour et compare ces resultats entre les patients de plus ou de moins de 65 ans. L'efficacite etait jugee sur la mesure automatique iterative de la PA au cabinet et sur l'automesure. La tolerance etait appreciee a partir de questionnaires libres et diriges, sur la mesure du poids et de la circonference supramalleolaire. Six cent quatre-vingt-onze patients sont analyses en ITT, 410 patients ont a la fois l'ensemble des mesures cliniques et des automesures validees. La lercanidipine apparait plus efficace chez les sujets âges pour la PAD et la pression pulsee avec la mesure automatique clinique, alors qu'en automesure seule la pression pulsee demeure significativement differente. La tolerance est excellente et comparable dans les deux groupes d'âge. Les œdemes des membres inferieurs sont peu frequents (3,2 %). La frequence cardiaque diminue de 1,9 battements (NS), le poids diminue tres legerement (0,15 ± 1,97 Kgp = 0,04), les questionnaires ne font pas ressortir de difference entre les plus jeunes et les moins jeunes et la circonference malleolaire augmente de facon identique de 1 mm ( p = 0,03). Au total : La lercanidipine fait efficacement baisser la pression arterielle (AMT : PAS : –11 mmHg, PAD : –5 mmHg) et elle est tres bien toleree quel que soit l'âge. Seule la pression pulsee baisse davantage chez les plus âges. La bonne tolerance de la lercanidipine est confirmee notamment sur la faible incidence des œdemes des membres inferieurs.
Published: 2004
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28. Dietary sodium and pulse pressure in normotensive and essential hypertensive subjects

Author: Albert Mimran, Jean Ribstein, Guilhem du Cailar, Jacques Blacher, Michel E. Safar, and Pierre Fesler
Subjects: Adult, Male, medicine.medical_specialty, Adolescent, Physiology, Population, Blood Pressure, Excretion, Dietary Sodium, Sodium excretion, Internal medicine, Internal Medicine, medicine, Humans, education, Aged, Aged, 80 and over, education.field_of_study, Urinary sodium, business.industry, Sodium, Dietary, Middle Aged, Pulse pressure, Cross-Sectional Studies, Endocrinology, Mean blood pressure, Blood pressure, Echocardiography, Hypertension, Multivariate Analysis, Cardiology, Female, Hypertrophy, Left Ventricular, France, Cardiology and Cardiovascular Medicine, business
Abstract: OBJECTIVES To assess the influence of sodium intake on the two components of arterial blood pressure [mean blood pressure (MBP) and pulse pressure] and left ventricular mass (LVM) in normotensive subjects and never-treated hypertensive patients. METHODS Blood pressure, LVM (M-mode echocardiography) and sodium excretion as an index of dietary sodium were measured in 459 males and 396 females, aged 14-93 years, with elevated (63% of population) or normal blood pressure. RESULTS Because pulse pressure decreased with age up to approximately 40 years of age, and increased thereafter, analysis was undertaken separately in 438 young (age < or = 40 years) and 417 middle-aged to elderly subjects. Before age 40 years, only pulse pressure was independently and positively influenced by urinary sodium excretion. After age 40 years, MBP and LVM index but not pulse pressure were positively influenced by urinary sodium excretion. When men and women were analysed separately according to tertiles of urinary sodium excretion, pulse pressure adjusted for MBP and age increased from the first to the third tertile of urinary sodium excretion in males (P < 0.03), but not in females. CONCLUSIONS The influence of sodium intake on pulse pressure was found in the younger subjects of both males and females and only in men older than 40 years.
Published: 2004
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29. Left Ventricular Remodeling and Renal Function in Never-Treated Essential Hypertension

Author: Albert Mimran, Jean Ribstein, Pierre Fesler, and Guilhem du Cailar
Subjects: Adult, Male, Aging, medicine.medical_specialty, Adolescent, Population, Renal function, Kidney, Essential hypertension, Severity of Illness Index, Muscle hypertrophy, Internal medicine, medicine, Humans, Ventricular remodeling, education, Aged, education.field_of_study, Anatomy, Cross-Sectional, Ventricular Remodeling, business.industry, General Medicine, Effective renal plasma flow, Middle Aged, medicine.disease, Renal Plasma Flow, Effective, medicine.anatomical_structure, Endocrinology, Echocardiography, Nephrology, Hypertension, Cardiology, Female, Hypertrophy, Left Ventricular, Kidney Diseases, business, Glomerular Filtration Rate, Kidney disease
Abstract: In the general population, renal function linearly declines with age; hypertension may accelerate this decline. Because concentric left ventricular (LV) hypertrophy is a strong marker of the severity of hypertension, the influence of LV geometry on the age-associated decline in renal function was assessed in 195 normotensive subjects and 645 patients with never-treated essential hypertension with an average duration of 30 mo. According to LV mass and relative wall thickness, hypertensive patients were divided into normal LV (NL, 48%), concentric remodeling (CR, 19%), and concentric (CH, 22%) and eccentric (EH, 11%) hypertrophy. GFR and effective renal plasma flow (ERPF) were estimated by isotopic clearance technique. GFR and ERPF were inversely correlated with age in normotensive and hypertensive subjects, and no marked influence of the BP level or the presence of LV hypertrophy was detected. However, the slope of the regression line of GFR versus age was accentuated (P0.01) in patients with CH or CR (slope values of -0.95 +/- 0.11, -0.86 +/- 0.14 ml/min per yr, respectively) when compared with patients with EH or NL (slope values of -0.58 +/- 0.16 and -0.58 +/- 0.08 ml/min per yr, respectively). No such results were obtained when creatinine clearance was considered. Urinary albumin excretion was higher in patients with concentric or eccentric LV hypertrophy than in patients with concentric LV remodeling or normal LV. These results demonstrate that in never-treated essential hypertension, the age-associated decline in GFR is markedly influenced by the concentric pattern of LV response to hypertension rather than the level of BP and/or the presence of LV hypertrophy.
Published: 2003
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30. Dietary sodium and target organ damage in essential hypertension

Author: Guilhem du Cailar, Albert Mimran, and Jean Ribstein
Subjects: Adult, Male, medicine.medical_specialty, Adolescent, Urinary system, Sodium, Natriuresis, chemistry.chemical_element, Blood Pressure, Left ventricular hypertrophy, Essential hypertension, Excretion, Internal medicine, Internal Medicine, medicine, Albuminuria, Humans, Aged, business.industry, Sodium, Dietary, Middle Aged, medicine.disease, Blood pressure, Endocrinology, chemistry, Echocardiography, Hypertension, Cardiology, Female, Hypertrophy, Left Ventricular, Microalbuminuria, business
Abstract: In addition to its widely contested influence on arterial pressure, dietary sodium may exert some nonpressure-related effects on left ventricular mass in humans. In the present study, we hypothesized that sodium intake (estimated by two consecutive measurements of 24-h urinary sodium excretion) may amplify the effect of arterial pressure on target organ damage (ie, left ventricular mass and microalbuminuria) in a large group of normotensive subjects and patients with never-treated uncomplicated essential hypertension. Left ventricular mass (M-mode echocardiography) and urinary albumin excretion were assessed in 839 subjects (471 men and 368 women) aged 15 to 70 years, with elevated (60%) or normal arterial pressure. In the entire population, multivariate analysis indicated that the relationship between urinary sodium excretion and left ventricular mass index (beta = 0.02, P < .01) as well as urinary albumin excretion (beta = 0.001, P < .0001) was independent from sex, age, body mass index, and systolic arterial pressure. When subjects were divided into quintiles according to urinary sodium excretion, left ventricular mass index and urinary albumin excretion increased significantly from the lowest to the highest quintile in both genders, despite similar values of systolic arterial pressure. The slope of the regression line linking systolic arterial pressure to left ventricular mass index (in men) and urinary albumin excretion (in the entire population) obtained within each quintile of urinary sodium excretion, progressively and linearly increased from the lowest to the highest quintile. These results suggest that sodium intake may amplify the effect of arterial pressure on both the left ventricle and the kidney, and thus suggest that dietary sodium may be an independent factor of cardiovascular risk.
Published: 2002
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31. Retinal vascular caliber associated with cardiac and renal target organ damage in never-treated hypertensive patients

Author: Max Villain, Loic Granados, Jean Ribstein, Pierre Fesler, Albert Mimran, Ryo Kawasaki, Guilhem du Cailar, Vincent Daien, Service d'Ophtalmologie [Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Guy de Chauliac, Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Université de Montpellier (UM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Herrada, Anthony, Université Montpellier 1 (UM1)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Male, [SDV.MHEP.HEM] Life Sciences [q-bio]/Human health and pathology/Hematology, Central retinal artery, Physiology, 030204 cardiovascular system & hematology, Fundus (eye), Kidney, Left ventricular hypertrophy, chemistry.chemical_compound, 0302 clinical medicine, Image Processing, Computer-Assisted, Prospective Studies, Pulse wave velocity, ComputingMilieux_MISCELLANEOUS, Aged, 80 and over, [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology, Middle Aged, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, medicine.anatomical_structure, Cardiology, Female, Hypertrophy, Left Ventricular, target organ damages, medicine.symptom, Cardiology and Cardiovascular Medicine, Glomerular Filtration Rate, Adult, medicine.medical_specialty, hypertension, microcirculation, Renal function, 03 medical and health sciences, Vascular Stiffness, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Physiology (medical), medicine.artery, Internal medicine, medicine, Albuminuria, Humans, Vein, Molecular Biology, Aged, business.industry, Myocardium, retinal vessels, Retinal, medicine.disease, Cross-Sectional Studies, chemistry, 030221 ophthalmology & optometry, business
Abstract: Objective The aim of this study was to assess the relationship between retinal vascular caliber and target organ damage in hypertensive patients (HT). Methods Data were collected on cardiac, renal, vascular and retinal variables in 88 consecutive never-treated HT subjects. Retinal vascular calibers were measured from fundus photographs by using a semi-automated computer-assisted program and summarized as central retinal artery and vein equivalent (CRAE, CRVE). Results Mean CRAE and CRVE were significantly lower in patients with left ventricular hypertrophy (left ventricular mass ≥ 110 g/m² for women, 125 g/m² for men) than those with normal left ventricular (CRAE: 129.4±3.7 vs 138.2±2.3 μm; p= 0.04; CRVE: 195.6±4.4 vs 209.8±2.7μm; p=0.008). CRAE and CRVE were negatively correlated with urinary albumin excretion (β±SE =-15.4±3.2, p
Published: 2017
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32. MACVIA-LR, Reference site of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) in Languedoc Roussillon

Author: Jean L. Bourrain, D. Heve, Jean-Christophe Gris, H. Dhivert-Donnadieu, G. Mathieu, Michel Mondain, S. Perrey, Jean Bousquet, V. Bouix, I. Rédini-Martinez, Patrick Messner, Claude Jeandel, F. Abecassis, Pierre Fesler, A. Bedbrook, V. Handweiler, Dominique Larrey, D. J. Costa, P. Dauenhauer, Fares Gouzi, Giacomo Cavalli, P. Martin-Gousset, Michel David, Hervé Tassery, N. Best, S. Albert, M.P. Pasdelou, Jean-Paul Cristol, Gregoire Mercier, D. Jakovenko, S. Cade, Justin Michel, Christian Jorgensen, Michel Dauzat, X. Vasquez, G. Pandraud, M. Gellerat-Rogier, Olivier Jonquet, G. Crooks, J.M. Davy, Bruno Vellas, Hubert Blain, J.M. Lussert, Kevin Mandrick, Jacques Reynes, E. Pastor, Marie Christine Picot, J.-E. de La Coussaye, Philippe Courtet, Ariane Sultan, Jacques Bringer, Fabrice Leclerc, Antoine Avignon, Joël Ankri, M. Nogues, Jacquie Berthe, B. Alomène, Michel Kaczorek, Mélanie Badin, A. Salvat, Isabelle Quéré, F. Viart, Christine Viarouge-Reunier, Sylvain Lehmann, M. Lapierre, G. Tallon, P.A. Adnet, C. Laurent, S. Granier, Laurence Vian, J.P. Ortiz, Claire Daien, François Vialla, Frédéric Cuisinier, Jean Ribstein, Karen Ritchie, Bernard Combe, Gérard Bourrel, Vivien Marmelat, J.L. Pujol, Pierre Costa, S. Jacquemin, T. Strandberg, P. Dujols, Guillaume Cayla, B. Samolinski, Pascal Demoly, Gilles Berrut, Gérard Dray, Benoît G. Bardy, E. Viollet, A. Uziel, Philippe Augé, Michel Amouyal, E. Royère, P. Nerin, Sofiane Ramdani, A. Matheron, Béatrice Lognos, J. Burille, C. Rolland, Davide Caimmi, Didier Delignières, Daniel Laune, M.P. Battesti, Yannick Stephan, M.S. Léglise, V. Attalin, O. Engberink, Y.M. Pers, N. Pinto, F. Nouvel, Samir Jaber, Claudine Berr, P.L. Bernard, Jacques Mercier, J. Pelissier, C. Bourquin, D. Hoa, J.P. Pin, J.L. Savy, G. Baptista, Rodolphe Bourret, Grégory Ninot, S. Arnavieilhe, Jean-Luc Pasquié, Maurice Hayot, Jean-Marie Robine, Pierre Aubas, M.C. Courrouy-Michel, Kjerstin Torre, F. Gressard, G. Dupeyron, Joël Bockaert, M. E. Joel, Jerôme Morel, David Morquin, M. Aoustin, E. Roux, Xavier Quantin, M.V. Calmels, Grégoire Vergotte, François Roubille, F. Portejoie, P. Domy, O. Benezet, Bernard Guillot, William Camu, Jean-Michel Verdier, Arnaud Bourdin, P. Van de Perre, M. Villain, Christine Meunier, F. Radier-Pontal, Sylvain Richard, L. Journot, Isabelle Laffont, Nicolas Giraudeau, Raphaël Chiron, Arnaud Dupeyron, A. Le Quellec, N. Raffort, T. Camuzat, D. Strubel, C. Boubakri, M. Danko, Biocommunication en Cardio-Métabolique (BC2M), Université de Montpellier (UM), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Département de Gériatrie, Institut fédératif de recherche sur le handicap / Réseau fédératif de recherche sur le handicap (IFRH / RFRH), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université de Lille, Droit et Santé-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Sciences Humaines et Sociales-CTNERHI-INST GARCHES-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Paris Diderot - Paris 7 (UPD7)-Université Jean Monnet [Saint-Étienne] (UJM)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Bourgogne (UB)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université de Lille, Sciences et Technologies-Université Bordeaux Segalen - Bordeaux 2-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national d'études démographiques (INED)-Université Montpellier 1 (UM1)-Université Paris 1 Panthéon-Sorbonne (UP1), CHU Saint-Eloi, Laboratoire de magnétisme et d'optique de Versailles (LMOV), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Institut de Génomique Fonctionnelle (IGF), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), ONERA - The French Aerospace Lab [Lille], ONERA, Service de cardiologie [Montpellier], Centre de résonance magnétique biologique et médicale (CRMBM), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM), Institut de génétique humaine (IGH), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centres de Ressources et de Compétences de la Mucoviscidose [Montpellier] (CRCM [Montpellier]), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Arnaud de Villeneuve-Service des Maladies Respiratoires, Hôpital Lapeyronie [Montpellier] (CHU), Laboratoire Evolution, Génomes et Spéciation (LEGS), Centre National de la Recherche Scientifique (CNRS), George Mason University [Fairfax], Polymer Institute (PI), Slovak Academy of Science [Bratislava] (SAS), Centre Sciences des Processus Industriels et Naturels (SPIN-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Conduites Addictives, de Performance et Santé, Université Montpellier 1 (UM1), Département pneumologie et addictologie [Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Arnaud de Villeneuve, Service de Médecine Physique et de Réadaptation, Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Cristallographie, Résonance Magnétique et Modélisations (CRM2), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche en Infectiologie de Montpellier (IRIM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Médecine interne, maladies multi-organiques de l'adulte [Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-CHU Saint-Eloi, Departement de Cardiologie, CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) (CEA-DES (ex-DEN)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Telecom Bretagne, Brest, Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) (FEMTO-ST), Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS), Service d'ORL, Hôpital Gui de Chauliac (CHRU de Montpellier), Dynamique des capacités humaines et des conduites de santé (EPSYLON), Université Montpellier 1 (UM1)-Université Paul-Valéry - Montpellier 3 (UPVM)-Université de Montpellier (UM), Laboratoire composants et systèmes pour télécommunications (LCST), Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES), Centre d'Estudis del Risc Tecnològic, Universitat Politècnica de Catalunya [Barcelona] (UPC), Domaines Océaniques (LDO), Centre National de la Recherche Scientifique (CNRS)-Institut d'écologie et environnement-Observatoire des Sciences de l'Univers-Université de Brest (UBO)-Institut national des sciences de l'Univers (INSU - CNRS), Hôpital Arnaud de Villeneuve [CHRU Montpellier], Service de gérontologie et de prévention du vieillissement, Institut de Recherche en Sciences de la Santé (IRSS) / Centre Muraz, Laboratoire Pierre Aigrain (LPA), Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris (FRDPENS), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut de biologie et chimie des protéines [Lyon] (IBCP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Institut d'Electronique du Solide et des Systèmes (InESS), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Department of Prevention of Environmental Hazards and Allergology, Medical University of Warsaw - Poland-Faculté de Pharmacie de Paris, Gérontopôle, Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Toulouse [Toulouse], Centre de pharmacologie et innovation dans le diabète ( CPID ), Université Montpellier 1 ( UM1 ) -Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Centre National de la Recherche Scientifique ( CNRS ), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] ( PhyMedExp ), Centre National de la Recherche Scientifique ( CNRS ) -Université de Montpellier ( UM ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ), Institut fédératif de recherche sur le handicap / Réseau fédératif de recherche sur le handicap ( IFRH / RFRH ), Université Panthéon-Sorbonne ( UP1 ) -Université Montpellier 1 ( UM1 ) -Institut national d'études démographiques ( INED ) -Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Université Bordeaux Segalen - Bordeaux 2-Université de Lille, Sciences et Technologies-Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Université de Bourgogne ( UB ) -Université de Valenciennes et du Hainaut-Cambresis ( UVHC ) -Université Jean Monnet [Saint-Étienne] ( UJM ) -Université Paris Diderot - Paris 7 ( UPD7 ) -Conservatoire National des Arts et Métiers [CNAM] ( CNAM ) -INST GARCHES-CTNERHI-Université de Lille, Sciences Humaines et Sociales-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Lille, Droit et Santé-Université de Rennes 2 ( UR2 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Université de Lorraine ( UL ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de magnétisme et d'optique de Versailles ( LMOV ), Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Centre National de la Recherche Scientifique ( CNRS ), Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] ( CAPS ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon ( MACVIA-LR ), Université Montpellier 1 ( UM1 ) -World Health Organization ( WHO/OMS ) -Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre Hospitalier Régional Universitaire de Nîmes ( CHRU Nîmes ) -Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ) -European Innovation Partnership on Active and Healthy Ageing Reference Site, Institut de Génomique Fonctionnelle ( IGF ), Centre National de la Recherche Scientifique ( CNRS ) -Université Montpellier 2 - Sciences et Techniques ( UM2 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Montpellier 1 ( UM1 ) -Université de Montpellier ( UM ), ONERA - The French Aerospace Lab ( Lille ), Institut des molécules et des matériaux du Mans ( IMMM ), Le Mans Université ( UM ) -Centre National de la Recherche Scientifique ( CNRS ), Centre de résonance magnétique biologique et médicale ( CRMBM ), Aix Marseille Université ( AMU ) -Assistance Publique - Hôpitaux de Marseille ( APHM ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de génétique humaine ( IGH ), Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ), Centres de Ressources et de Compétences de la Mucoviscidose [Montpellier] ( CRCM [Montpellier] ), Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Hôpital Arnaud de Villeneuve-Service des Maladies Respiratoires, Hôpital Lapeyronie [Montpellier] ( CHU ), Laboratoire Evolution, Génomes et Spéciation ( LEGS ), Centre National de la Recherche Scientifique ( CNRS ), Polymer Institute ( PI ), Slovak Academy of Science [Bratislava] ( SAS ), Centre Sciences des Processus Industriels et Naturels ( SPIN-ENSMSE ), École des Mines de Saint-Étienne ( Mines Saint-Étienne MSE ), Institut Mines-Télécom [Paris]-Institut Mines-Télécom [Paris], Université Montpellier 1 ( UM1 ), Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Hôpital Arnaud de Villeneuve, Centre Hospitalier Universitaire de Nîmes ( CHU de Nîmes ), Cristallographie, Résonance Magnétique et Modélisations ( CRM2 ), Centre National de la Recherche Scientifique ( CNRS ) -Université de Lorraine ( UL ), Hop St Eloi, Serv Anesthesie Reanimat B, Centre Hospitalier Universitaire de Montpellier ( CHU Montpellier ), Institut de Recherche en Infectiologie de Montpellier ( IRIM ), Centre National de la Recherche Scientifique ( CNRS ) -Université de Montpellier ( UM ), Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -CHU Saint-Eloi, CEA-Direction de l'Energie Nucléaire ( CEA-DEN ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies ( FEMTO-ST ), Université de Technologie de Belfort-Montbeliard ( UTBM ) -Ecole Nationale Supérieure de Mécanique et des Microtechniques ( ENSMM ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Franche-Comté ( UFC ), Service d'ORL, Hôpital Gui de Chauliac ( CHRU de Montpellier ), Dynamique des capacités humaines et des conduites de santé ( EPSYLON ), Université Paul-Valéry - Montpellier 3 ( UM3 ) -Université Jean Monnet [Saint-Étienne] ( UJM ) -Université Montpellier 1 ( UM1 ) -Université de Montpellier ( UM ), Laboratoire composants et systèmes pour télécommunications ( LCST ), Institut National des Sciences Appliquées ( INSA ), Centre de Thermique de Lyon ( CETHIL ), Centre National de la Recherche Scientifique ( CNRS ) -Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon ( INSA Lyon ), Université de Lyon-Institut National des Sciences Appliquées ( INSA ) -Institut National des Sciences Appliquées ( INSA ), Universitat Politècnica de Catalunya [Barcelona] ( UPC ), Domaines Océaniques ( LDO ), Centre National de la Recherche Scientifique ( CNRS ) -Institut d'écologie et environnement-Observatoire des Sciences de l'Univers-Université de Brest ( UBO ) -Institut national des sciences de l'Univers ( INSU - CNRS ), Hôpital Arnaud de Villeneuve, Centre Hospitalier Régional Universitaire de Nîmes ( CHRU Nîmes ), Centre Muraz, Laboratoire Pierre Aigrain ( LPA ), Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris ( FRDPENS ), Centre National de la Recherche Scientifique ( CNRS ) -École normale supérieure - Paris ( ENS Paris ) -Centre National de la Recherche Scientifique ( CNRS ) -École normale supérieure - Paris ( ENS Paris ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de biologie et chimie des protéines [Lyon] ( IBCP ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique ( CNRS ), Institut d'Electronique du Solide et des Systèmes ( InESS ), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique ( CNRS ), Medical University of Warsaw-Faculté de Pharmacie de Paris, Gerontopole of Toulouse, CHU- Université de Toulouse, Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université de Lille, Droit et Santé-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Sciences Humaines et Sociales-CTNERHI-INST GARCHES-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Paris Diderot - Paris 7 (UPD7)-Université Jean Monnet [Saint-Étienne] (UJM)-Université Polytechnique Hauts-de-France (UPHF)-Université de Bourgogne (UB)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université de Lille, Sciences et Technologies-Université Bordeaux Segalen - Bordeaux 2-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national d'études démographiques (INED)-Université Montpellier 1 (UM1)-Université Panthéon-Sorbonne (UP1), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Nîmes (CHRU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Institut des Molécules et Matériaux du Mans (IMMM), Le Mans Université (UM)-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire de Nîmes (CHU de Nîmes), Centre de pharmacologie et innovation dans le diabète (CPID), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL), Centre Hospitalier Universitaire de Montpellier (CHU Montpellier ), CEA-Direction de l'Energie Nucléaire (CEA-DEN), Université de Franche-Comté (UFC)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Technologie de Belfort-Montbeliard (UTBM), Université Montpellier 1 (UM1)-Université Paul-Valéry - Montpellier 3 (UM3)-Université de Montpellier (UM), Centre Hospitalier Régional Universitaire de Nîmes (CHRU Nîmes), Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées
Subjects: Gerontology, Pediatrics, medicine.medical_specialty, media_common.quotation_subject, Reference site, [SDV]Life Sciences [q-bio], Oral health, Clinical decision support system, 03 medical and health sciences, 0302 clinical medicine, Promotion (rank), medicine, media_common.cataloged_instance, 030212 general & internal medicine, European union, ComputingMilieux_MISCELLANEOUS, media_common, [ SDV ] Life Sciences [q-bio], business.industry, 3. Good health, 030228 respiratory system, General partnership, Healthy ageing, Geriatrics and Gerontology, business, Independent living
Abstract: The Region Languedoc-Roussillon is the umbrella organisation for an interconnected and integrated project on AHA covering the 3 pillars of the European Innovation Partnership on Active and Healthy Ageing. All sub-activities (A1: electronic pharmaceutical file, A2: falls prevention initiative, A3: frailty, B3: chronic respiratory diseases, chronic diseases with comorbidities, oral health and hepatitis virus C chronic infection, C2 and D4 active and independent living and handicap) are included in MACVIA-LR that has a strong political commitment and includes all stakeholders (public, private, patients, policy makers). It is one of the Reference Sites of the European Innovation Partnership on Active and Healthy Ageing built around chronic diseases, ageing and handicap. The framework of MACVIA-LR has the vision that the prevention and management of CDs is essential for AHA promotion and for the reduction of handicap. The main objective of MACVIA-LR is to develop innovative solutions for a network of Living Labs in order to improve the care of patients affected by CDs in the Languedoc-Roussillon area and to disseminate the innovation.
Published: 2014
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33. Evaluation of five immunoturbidimetric assays for urinary albumin quantification and their impact on albuminuria categorization

Author: Pierre Fesler, Jean-Paul Cristol, Nils Kuster, Stéphanie Badiou, Jean Ribstein, Amandine Barrot, Anne-Marie Dupuy, and Anne-Sophie Bargnoux
Subjects: Immunoassay, Creatinine, Urinary albumin, Chromatography, medicine.diagnostic_test, Chemistry, Concordance, Clinical Biochemistry, Albumin, General Medicine, Urine, Immunoturbidimetric Assays, Sensitivity and Specificity, chemistry.chemical_compound, Nephelometry and Turbidimetry, Albumins, Albuminuria, medicine, Humans, medicine.symptom
Abstract: The study was designed to evaluate the performance of five automated immunoturbidimetric assays to quantify urinary albumin, each corresponding to a combination of a reagent and an analyzer (Olympus on AU640, Roche on Cobas Integra, Abbott on Architect, Ortho-Clinical Diagnostics Vitros on Fusion and Siemens on Dimension).To assess imprecision, albumin was measured in three urinary pools with a mean value of 25, 66 and 131 mg/L. One hundred and eight patient urine samples were then used to compare each turbidimetric method using the Passing-Bablok regression and Bland-Altman analyses. Concordance of the albumin/creatinine ratio (ACR), according to the albuminuria classifications proposed by the KDIGO, was calculated to test the agreement between the different assays.All immunoturbidimetric methods evaluated in this study exhibited acceptable imprecision (CV6%). Mean values for 108 urine samples varied from 0.5 to 762.2 mg/L. Significant differences were found (p0.05) between all methods except between Olympus and Ortho (p=1.0) and between Abbott and Roche (p=0.12). Regarding the albuminuria categories based on the ACR proposed by the KDIGO, only the classification obtained with the Roche method was significantly different from the four other methods (p0.001).We demonstrated that all assays were not strictly equivalent which could affect ACR categories in clinical practice, suggesting the need for harmonization of commercial methods.
Published: 2014

34. Glucose tolerance and age-associated decline in renal function of hypertensive patients

Author: Albert Mimran, Guilhem du Cailar, and Jean Ribstein
Subjects: Adult, Blood Glucose, Male, Aging, medicine.medical_specialty, Physiology, Population, Renal function, Blood Pressure, Kidney, Renal Circulation, Impaired glucose tolerance, Diabetes mellitus, Internal medicine, Glucose Intolerance, Internal Medicine, Humans, Medicine, education, Aged, Glucose tolerance test, education.field_of_study, Renal circulation, medicine.diagnostic_test, business.industry, Fasting, Middle Aged, medicine.disease, Pathophysiology, medicine.anatomical_structure, Endocrinology, Blood pressure, Hypertension, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, Glomerular Filtration Rate
Abstract: Renal function is thought to decrease with age in the general population, but the determinants of this age-associated evolution are poorly understood. Hypertension and diabetes mellitus, two leading causes of chronic renal failure in the elderly, may accelerate this decline.Urinary clearances of [99mTc]diethylene triaminopentaacetic acid (DTPA) (glomerular filtration rate) and [131I]hippuran (effective renal plasma flow) were assessed in 227 never-treated essential hypertensives aged 20-69 years. Based on the oral glucose tolerance test, the study population consisted of 4% patients with previously unknown diabetes mellitus, 24% with impaired glucose tolerance and 72% with normal glucose tolerance.When the population of 218 non-diabetic subjects was considered, glomerular filtration rate was inversely correlated with age and arterial blood pressure, and positively correlated with effective renal plasma flow, filtration fraction and fasting plasma glucose. In multivariate analysis, age and blood pressure were independent determinants of renal plasma flow, whereas renal plasma flow, age and fasting plasma glucose were independent determinants of glomerular filtration rate. The slope of the regression line relating glomerular filtration rate to age was steeper in patients with impaired glucose tolerance than in those with normal glucose tolerance (-1.52 +/- 0.28 versus -0.65 +/- 0.12, P0.01).These results suggest that impaired glucose tolerance, which is seldom searched for in patients with essential hypertension, may be an important determinant of the age-associated decline in renal function.
Published: 2001
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35. Inhibition of the Acute Effects of Angiotensin II by the Receptor Antagonist Irbesartan in Normotensive Men

Author: Jean Ribstein, Catherine Armagnac, Annie Picard, Joëlle Sissmann, and Albert Mimran
Subjects: Adult, Male, medicine.medical_specialty, medicine.drug_class, Tetrazoles, Blood Pressure, Receptor, Angiotensin, Type 2, Receptor, Angiotensin, Type 1, Angiotensin Receptor Antagonists, chemistry.chemical_compound, Irbesartan, Heart Rate, Internal medicine, Renin, Renin–angiotensin system, medicine, Humans, Aldosterone, Antihypertensive Agents, Pharmacology, Analysis of Variance, business.industry, Angiotensin II, Biphenyl Compounds, Antagonist, Receptor antagonist, Blood pressure, Endocrinology, Mechanism of action, chemistry, Regression Analysis, medicine.symptom, Cardiology and Cardiovascular Medicine, business, medicine.drug
Abstract: Summary: Irbesartan (SR 47436, BMS 186295) is an imidazole derivative that specifically binds to the angiotensin type 1 receptor. The purpose of this study was to assess the inhibitory effect of irbesartan on the pressor action of exogenous angiotensin II in healthy subjects, to evaluate the dose dependency and duration of this inhibition, and to determine the effect of irbesartan on plasma components of the renin-angiotensin system. Forty-two healthy male volunteers maintained on ad libitum sodium intake were enrolled in a randomized, double-blind, placebo-controlled, parallel-design, dose-ranging study. On 2 study days 1 week apart, volunteers were given either a placebo or the active drug at one of the chosen doses (5, 25, 50, 75, 100, 150, or 300 mg). The pressor effects of an individually titrated test dose of exogenous angiotensin II as well as plasma levels of angiotensin II, active renin, aldosterone, and treatment drug were determined before and throughout the 24 h after drug administration. The inhibitory effect of irbesartan on the pressor response to angiotensin II was observed within 1 h after dosing, peaked between 2 and 4 h, and lasted more than 24 h for doses of 25 mg and more. The effect was clearly dose related. Two and 24 h after administration of irbesartan, 300 mg, the response of arterial blood pressure (systolic and diastolic) to a given dose of angiotensin II was reduced by approximately 100% and 60%, respectively. Plasma concentrations of angiotensin II and active renin increased markedly after irbesartan administration, whereas plasma concentrations of aldosterone decreased. No evidence was found that the high levels of circulating angiotensin II observed after irbesartan administration could override the inhibitory effect of irbesartan on any of the measured parameters up to 24 h after dose. In conclusion, irbesartan appears to be a well-tolerated, orally active, potent antagonist of the renin-angiotensin system in men.
Published: 2001
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36. Renal Characteristics and Effect of Angiotensin Suppression in Oral Contraceptive Users

Author: Jean-Michel Halimi, Albert Mimran, Guilhem du Cailar, and Jean Ribstein
Subjects: Adult, medicine.medical_specialty, Captopril, Radioimmunoassay, Urology, Hemodynamics, Renal function, Angiotensin-Converting Enzyme Inhibitors, Blood Pressure, Kidney, Essential hypertension, Plasma renin activity, Renin-Angiotensin System, Internal medicine, Renin, Internal Medicine, medicine, Humans, Aldosterone, Antihypertensive Agents, business.industry, Effective renal plasma flow, Middle Aged, medicine.disease, Contraceptives, Oral, Combined, Endocrinology, medicine.anatomical_structure, Blood pressure, Data Interpretation, Statistical, Renal physiology, Hypertension, Female, business, Glomerular Filtration Rate
Abstract: Abstract —The determinants of the increase in arterial blood pressure associated with the use of estrogen-progestogen oral contraceptives (OC) remain poorly known. The purpose of this study was to assess the renal characteristics and the role of the renin-angiotensin system in women with OC-associated hypertension. Urinary clearances of technetium-labeled diethylene triaminopentaacetic acid (glomerular filtration rate) and 131 I-ortho iodohippurate (effective renal plasma flow) were estimated before and after acute administration of captopril in 38 women who became hypertensive while taking OC, 38 non-OC users with essential hypertension matched for age, body mass index, and level of blood pressure, and 38 normotensive women (19 with and 19 without OC). Plasma renin activity was higher in OC hypertensives when compared with those with essential hypertension, but captopril-induced changes in blood pressure and renal hemodynamics and function were similar in both groups. In addition, 24-hours urinary albumin excretion was increased in OC users when compared with nonusers with similar arterial blood pressure. In 13 hypertensive women followed up for 6 months after OC withdrawal, a decrease in plasma renin activity, blood pressure, and glomerular filtration rate but no significant change in urinary albumin excretion and captopril-induced changes in blood pressure and renal hemodynamics were observed. These results indicate that the use of OC is associated with an increased albuminuria and no evidence of a prominent role for the renin-angiotensin system in the maintenance of high blood pressure and renal hemodynamics when compared with non-OC users with essential hypertension.
Published: 1999
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37. LONG-TERM IMPROVEMENT IN RENAL FUNCTION AFTER CYCLOSPORINE REDUCTION IN RENAL TRANSPLANT RECIPIENTS WITH HISTOLOGICALLY PROVEN CHRONIC CYCLOSPORINE NEPHROPATHY

Author: Albert Mimran, Georges Mourad, C Vela, and Jean Ribstein
Subjects: Adult, Male, medicine.medical_specialty, Time Factors, Biopsy, Urology, Renal function, Blood Pressure, Kidney Function Tests, Nephropathy, chemistry.chemical_compound, Internal medicine, medicine, Humans, Aged, Transplantation, Kidney, Creatinine, Proteinuria, Dose-Response Relationship, Drug, business.industry, Effective renal plasma flow, Middle Aged, medicine.disease, Kidney Transplantation, Filtration fraction, medicine.anatomical_structure, Endocrinology, chemistry, Chronic Disease, Cyclosporine, Female, Kidney Diseases, medicine.symptom, business, Follow-Up Studies, Glomerular Filtration Rate, Kidney disease
Abstract: BACKGROUND Chronic cyclosporine (CsA) nephropathy, which has been unequivocally documented in recipients of heart, heart-lung, liver, or bone marrow transplants, as well as in nontransplant situations, usually results in a progressive deterioration of renal function. In this study, we assessed the potential reversibility of chronic CsA nephropathy in renal transplant recipients. PATIENTS AND METHODS Twenty-three renal transplant patients with biopsy-proven CsA nephropathy associated with long-term CsA administration (27+/-4 months) were followed up for more than 2 years after CsA reduction (18/23 patients) or withdrawal (5/23 patients) and addition of azathioprine. Changes in effective renal plasma flow and glomerular filtration rate were assessed before and 2 years after CsA reduction, whereas serum creatinine, proteinuria, blood pressure, and CsA concentrations were monitored up to 5 years. RESULTS At 2-year follow-up, glomerular filtration rate increased from 40+/-3 to 47+/-4 (P
Published: 1998
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38. Influence of dopamine receptor and adrenoceptor blockade on the hemoconcentrating and hypotensive actions of atrial natriuretic peptide

Author: Nafrialdi Nafrialdi, Jean Ribstein, Albert Mimran, and Jean-Pierre Valentin
Subjects: Male, Nitroprusside, Adrenergic Antagonists, medicine.medical_specialty, Mean arterial pressure, Physiology, Vasodilator Agents, Adrenergic, Blood Pressure, Propranolol, Hematocrit, Nephrectomy, Rats, Sprague-Dawley, Phentolamine, Atrial natriuretic peptide, Heart Rate, Physiology (medical), Internal medicine, medicine, Haloperidol, Animals, Plasma Volume, Pharmacology, medicine.diagnostic_test, Chemistry, Blood Proteins, General Medicine, Blood proteins, Rats, Endocrinology, Dopamine Antagonists, Atrial Natriuretic Factor, medicine.drug
Abstract: Atrial natriuretic peptide (ANP) lowers mean arterial pressure (MAP) and increases hematocrit through reduction in plasma volume caused by a transcapillary shift of plasma fluid and protein toward the interstitium. We examined the consequences of blockade of the dopaminergic and adrenergic systems on the hypotensive and hemoconcentrating responses to ANP. Changes in MAP, hematocrit, and plasma protein concentration (PPC) were measured in anesthetized acutely binephrectomized rats, during infusion of ANP alone (1 microgram.kg-1.min-1 for 45 min) or in the presence of haloperidol (20 micrograms.kg-1.min-1), phentolamine (15 micrograms.kg-1.min-1), or propranolol (10 micrograms.kg-1.min-1). Infusion of ANP reduced MAP by 8.6 +/- 1.3% and increased hematocrit by 9.0 +/- 0.6% (both p0.005 vs. vehicle). PPC increased (4.4 +/- 0.6%; p0.005 vs. vehicle) significantly less than hematocrit, indicating extravasation of proteins. The ANP-evoked reduction in MAP was not affected in haloperidol- or phentolamine-treated rats (-8.8 +/- 2.3 and -10.5 +/- 2.4%, respectively; both p0.005 vs. vehicle) but was abolished in propranolol-treated rats (+3.2 +/- 1.3%; p = ns vs. vehicle). The ANP-induced increase in hematocrit was slightly attenuated in haloperidol-, phentolamine-, and propranolol-treated rats (7.5 +/- 0.7, 7.3 +/- 0.8, and 6.0 +/- 1%, respectively). In addition, the coefficient of reflection, an index of the permeability to proteins, was higher in these three groups (0.41 +/- 0.06, 0.49 +/- 0.08, and 0.57 +/- 0.14, respectively) than in control rats infused with ANP (0.27 +/- 0.03), indicating an attenuation of the ANP-induced extravasation of proteins. Thus, in binephrectomized rats, the hypotensive activity of ANP requires a beta-adrenergic component, whereas its hemoconcentrating action is, at least in part, dependent upon dopaminergic and adrenergic activation.
Published: 1997
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39. Validation of a new standardized cystatin C turbidimetric assay: evaluation of the three novel CKD-EPI equations in hypertensive patients

Author: Nils Kuster, Anne-Marie Dupuy, Anne-Sophie Bargnoux, Stéphanie Badiou, Jean-Paul Cristol, Julien Obiols, Pierre Fesler, Jean Ribstein, and Laurence Piéroni
Subjects: Adult, Male, medicine.medical_specialty, Accuracy and precision, Clinical Biochemistry, Urology, Renal function, urologic and male genital diseases, chemistry.chemical_compound, Limit of Detection, Nephelometry and Turbidimetry, Internal medicine, medicine, Humans, In patient, Cystatin C, reproductive and urinary physiology, Detection limit, Immunoassay, Creatinine, Models, Statistical, biology, medicine.diagnostic_test, business.industry, General Medicine, Middle Aged, female genital diseases and pregnancy complications, Endocrinology, chemistry, Hypertension, biology.protein, Technetium Tc 99m Pentetate, Female, Cystatin, business, Biomarkers, Glomerular Filtration Rate
Abstract: Objectives Analytical and clinical performances of the new standardized cystatin C particle-enhanced turbidimetric immunoassay (PETIA) using DiaSys reagents on Olympus AU2700® analyzer were evaluated. Design and methods We have studied imprecision, linearity, limit of detection and limit of quantification of this new immunoassay. Method comparison was assessed in relation to results generated by the standardized Siemens-particle-enhanced nephelometric immunoassay (PENIA). In order to evaluate the clinical relevance of this assay, estimated glomerular filtration rate (GFR) was calculated using MDRD, CKD-EPI creatinine, CKD-EPI cystatin C 2012 and CKD-EPI creatinine–cystatin C 2012 equations and compared to GFR measured using urinary clearance of 99mTc-DTPA in 100 hypertensive patients. Results Cystatin C measurements using DiaSys reagents have reliable analytical performances and are comparable to the standardized Siemens-PENIA method (bias of 0.01 mg/L). The mean measured GFR was 90.0 ± 29.7 mL/min/1.73 m2. Bias and accuracy of the three CKD-EPI equations were better than the MDRD. Both CKD-EPI creatinine-based and cystatin C-based formulae had similar bias, precision and accuracy. The combined creatinine–cystatin C equation was significantly more accurate and precise than the CKD-EPI creatinine equation in patients with GFR above 60 mL/min/1.73 m2. Conclusions The use of cystatin C in a combined equation with creatinine could improve the accuracy of eGFR in the reference interval.
Published: 2013

40. Left Ventricular Contractility and Insulin Resistance in Essential Hypertension

Author: Albert Mimran, Jean Ribstein, and du Cailar G
Subjects: Adult, Blood Glucose, Male, Cardiac function curve, medicine.medical_specialty, Supine position, Adolescent, medicine.medical_treatment, Administration, Oral, Essential hypertension, Ventricular Function, Left, Insulin resistance, Reference Values, Internal medicine, Heart rate, Internal Medicine, medicine, Humans, Insulin, business.industry, Area under the curve, General Medicine, Middle Aged, Left ventricular contractility, medicine.disease, Myocardial Contraction, Endocrinology, Echocardiography, Hypertension, Cardiology, Female, Insulin Resistance, Cardiology and Cardiovascular Medicine, business
Abstract: The relationship between fasting insulin as well as the insulin response to an oral glucose tolerance test and echocardiographic cardiac geometry and function was assessed in 55 never-treated lean patients with essential hypertension and normal glucose tolerance and 31 age- and gender-matched normal subjects. The ratio of the area under the curve of the response of insulin and glucose to the oral glucose load was positively correlated with supine heart rate (r values of 0.37) or left ventricular contractility estimated by the end-systolic wall stress to end-systolic volume index ratio and the afterload-corrected fractional shortening (r = 0.59 and 0.36, respectively). No correlation between insulin and left ventricular mass index was observed. When hypertensive patients were divided into those without (n = 39) and with insulin resistance (n = 16), as defined by an elevated value of the ratio of the area under the curve of the response of insulin and glucose, it appeared that both heart rate, end-systolic wall stress to end-systolic volume index ratio and afterload-corrected fractional shortening were higher in patients with insulin resistance, whereas age, arterial pressure, left ventricular mass index, urinary electrolytes, and plasma renin activity were similar in the two groups. These results suggest that increased cardiac systolic performance and heart rate may be associated with insulin resistance in a subset of lean patients with never-treated essential hypertension.
Published: 1995
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41. Angiotensin-Converting Enzyme Inhibitors Versus Calcium Antagonists in the Progression of Renal Diseases

Author: Albert Mimran and Jean Ribstein
Subjects: medicine.medical_specialty, Renal function, Angiotensin-Converting Enzyme Inhibitors, Pharmacology, urologic and male genital diseases, Nephropathy, Diabetic nephropathy, Diabetes mellitus, Internal medicine, Internal Medicine, medicine, Humans, Diabetic Nephropathies, Antihypertensive Agents, Proteinuria, biology, business.industry, Angiotensin-converting enzyme, Calcium Channel Blockers, medicine.disease, Endocrinology, Blood pressure, Albuminuria, biology.protein, Kidney Diseases, medicine.symptom, business
Abstract: In addition to factors such as protein intake or hyperlipidemia, hypertension contributes to the progressive deterioration of renal function in experimental animal models of renal disease, and has a prominent role in the imbalance of intrarenal hemodynamics. Reduction of arterial pressure was shown to alter the course of human chronic renal disease. In patients with diabetic as well as nondiabetic nephropathy, the lowering of proteinuria by angiotensin-converting enzyme inhibitors is greater than that observed with other antihypertensive drugs and appears to be independent of blood pressure control alone, whereas albuminuria may be unaffected or worsened during nifedipine treatment. Angiotensin-converting enzyme inhibitors may afford better protection than conventional treatment at various stages of diabetic nephropathy and prevent the evolution from incipient to overt nephropathy. In patients with nondiabetic renal disease, no unequivocal evidence exists for such a protective effect. In renal transplant recipients receiving cyclosporine, converting enzyme inhibitors and calcium antagonists are equally effective in the control of hypertension and both leave unaltered the glomerular filtration rate. It remains to be demonstrated, using adequate study designs, whether a particular class of agent is superior to another in patients with chronic renal disease.
Published: 1994
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42. Influence of Dopamine and Angiotensin II Blockade on the Acute Response to Unilateral Nephrectomy in Rats

Author: Jean Ribstein, Albert Mimran, and Jean-Pierre Valentin
Subjects: Male, medicine.medical_specialty, Dopamine, medicine.medical_treatment, Natriuresis, Renal function, Angiotensin-Converting Enzyme Inhibitors, Lithium, Kidney Function Tests, Nephrectomy, Renal Circulation, Rats, Sprague-Dawley, Renin-Angiotensin System, Enalapril, Internal medicine, medicine, Animals, Pharmacology, Kidney, biology, Chemistry, Angiotensin II, Hemodynamics, Angiotensin-converting enzyme, Blood Proteins, Rats, medicine.anatomical_structure, Endocrinology, Renal blood flow, Potassium, biology.protein, Dopamine Antagonists, Haloperidol, Cardiology and Cardiovascular Medicine, medicine.drug
Abstract: Unilateral nephrectomy (UNX) is followed by a prompt functional adaptation (as well as initiation of compensatory growth) in the contralateral kidney. We assessed the possibility that dopamine (DA) receptor antagonism and angiotensin-converting enzyme inhibition may influence the acute natriuretic response to UNX of the remaining kidney in euvolemic anesthetized Sprague-Dawley rats with or without pretreatment by haloperidol or enalapril. Twenty to 80 min after UNX, urinary excretion of sodium and potassium approximately doubled and fractional excretion of lithium (an index of proximal tubular handling of sodium) increased by about one third in untreated rats, whereas glomerular filtration rate, renal plasma flow and mean arterial pressure (MAP) did not change significantly. Haloperidol infusion blunted the post-UNX increase in fractional excretion of lithium without affecting the natriuretic/kaliuretic response of the remaining kidney. Enalapril pretreatment resulted in lower MAP and marked renal vasodilation at baseline but no significant alteration in the response to UNX. These results indicate that the magnitude of post-UNX natriuresis is not affected by suppression of angiotensin II (AII) generation or blockade of DA receptors. The lithium clearance data suggest that the immediate natriuretic response to UNX can be ascribed to both a proximal and a distal tubular phenomenon.
Published: 1994
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43. Treatment of hypertension with renin-angiotensin system inhibitors and renal dysfunction: a systematic review and meta-analysis

Author: Vincent Daien, Albert Mimran, Guilhem du Cailar, Max Villain, Pierre Fesler, Yohan Duny, Jean Pierre Daures, and Jean Ribstein
Subjects: medicine.medical_specialty, Angiotensin-Converting Enzyme Inhibitors, Cochrane Library, Essential hypertension, Renin-Angiotensin System, chemistry.chemical_compound, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Humans, Renal Insufficiency, Antihypertensive Agents, Randomized Controlled Trials as Topic, Creatinine, Kidney, business.industry, Odds ratio, medicine.disease, Confidence interval, medicine.anatomical_structure, chemistry, Meta-analysis, Hypertension, Kidney Failure, Chronic, business, Angiotensin II Type 1 Receptor Blockers
Abstract: Background To determine whether inhibitors of the renin-angiotensin system (RAS) reduce the incidence of renal dysfunction when compared to other antihypertensive treatments in patients with essential hypertension and no pre-existent renal disease. Methods The search strategy used the Cochrane Library, Medline, previous meta-analyses, and journal reviews. The selection criteria included randomized, controlled trials of antihypertensive drugs that compared a RAS inhibitor with another treatment in essential hypertension. Studies that specifically enrolled only patients with diabetes or renal disease were not included. The quality assessment and data extraction of studies were performed by two independent reviewers. Effects on dichotomous renal outcome (serum creatinine (SCreat) higher than a prespecified value, doubling of SCreat or end-stage renal disease) and secondary continuous marker of renal outcome (change in SCreat) were calculated using Peto's method. Results 33,240 patients met the inclusion criteria for studies with a dichotomous outcome and 10,634 patients for studies with a continuous outcome. The mean follow-up was 42 ± 13 months. Patients randomized to RAS inhibitors did not show a significant reduction in the risk of developing renal dysfunction as compared to other antihypertensive strategies (odds ratio = 1.05; 95% confidence interval (CI) 0.89-1.25; P = 0.54). There was no significant difference in change of SCreat between groups (mean difference = 0.0005 mg/dl; 95% CI -0.0068 to 0.0077 mg/dl; P = 0.91). Conclusion In patients with essential hypertension and no pre-existent renal disease, prevention of renal dysfunction is not significantly different with RAS inhibitors when compared to other antihypertensive agents.
Published: 2011

44. Early detection of isolated left ventricular diastolic dysfunction in high-risk differentiated thyroid carcinoma patients on TSH-suppressive therapy

Author: Véronique, Taillard, Mathieu, Sardinoux, Carole, Oudot, Pierre, Fesler, Caroline, Rugale, Isabelle, Raingeard, Eric, Renard, Jean, Ribstein, and Guilhem, du Cailar
Subjects: Adult, Male, Thyroxine, Ventricular Dysfunction, Left, Echocardiography, Case-Control Studies, Humans, Thyrotropin, Female, Thyroid Neoplasms, Middle Aged, Aged
Abstract: L-Thyroxine-suppressive therapy benefits high-risk differentiated thyroid cancer patients by decreasing recurrence rates and cancer-related mortality. However, fully suppressed serum thyroid-stimulating hormone (TSH) implies a state of subclinical hyperthyroidism (SCH) with associated adverse cardiac effects. Because left ventricular (LV) diastolic dysfunction may be the first manifestation of more severe LV failure, and to balance the risks from thyroid cancer recurrence with risks of cardiac failure, the purpose of this study was to analyse new parameters of LV function in asymptomatic patients with exogenous SCH.Case-control study with 24 patients on TSH-suppressive therapy of short duration (≤ 4 years) after thyroid ablative therapy for differentiated thyroid carcinoma and 20 age- and sex-matched subjects.LV function [LV global strain and strain rate (SR) curves] was assessed by speckle tracking imaging echocardiography in each subject.Patients and controls do not differ in body mass index, systolic blood pressure and heart rate. No significant differences were observed in LV morphology (LV mass and relative wall thickness), cardiac output and parameters of LV systolic function between patients on suppressive therapy and controls. When compared with controls, patients with exogenous SCH had a significantly impaired longitudinal protodiastolic strain, SR and strain diastolic index but preserved radial strain and SR function.In subjects with SCH at the early phase of TSH-suppressive therapy, evidence of isolated longitudinal LV diastolic dysfunction was observed, despite a normal LV morphology. Further prospective studies to clarify the prognosis of picking-up early diastolic dysfunction in asymptomatic patients are needed before serial measurements could be recommended.
Published: 2011

45. Endogenous angiotensin II but not atrial natriuretic peptide modulates the effect of nicardipine on extracellular fluid partition in the rat

Author: Nafrialdi Nafrialdi, Albert Mimran, Jean-Pierre Valentin, and Jean Ribstein
Subjects: Male, medicine.medical_specialty, Physiology, Nicardipine, Blood Pressure, Angiotensin II receptor antagonist, Rats, Sprague-Dawley, Renin-Angiotensin System, Atrial natriuretic peptide, Internal medicine, Renin–angiotensin system, Internal Medicine, medicine, Animals, Enalapril, biology, business.industry, Angiotensin II, Angiotensin-converting enzyme, Blood Proteins, Rats, Endocrinology, Losartan, Hematocrit, biology.protein, Extracellular Space, Cardiology and Cardiovascular Medicine, business, Atrial Natriuretic Factor, hormones, hormone substitutes, and hormone antagonists, circulatory and respiratory physiology, medicine.drug
Abstract: Objective Both atrial natriuretic peptide (ANP) and the dihydropyridine derivative nicardipine lower arterial pressure and induce a shift of plasma fluid from the vascular towards the interstitial compartment. Because some calcium antagonists increase the plasma concentration of ANP, and the effect of ANP on transcapillary fluid shift requires the presence of angiotensin II, we examined the consequences of blocking the ANP and renin-angiotensin systems on the hypotensive and haemoconcentrating effects of nicardipine. Methods We evaluated the effects of 45-min 0.1 or 1 micrograms/kg per min nicardipine infusion on arterial pressure and haematocrit in anaesthetized, acutely binephrectomized Sprague-Dawley rats. Results Infusion of nicardipine resulted in a dose-dependent decrease in arterial pressure. Haematocrit increased by an amount corresponding to the decrease in plasma volume calculated for the relevant dose. In the presence of monoclonal anti-ANP antibodies the nicardipine-induced changes in haematocrit and arterial pressure were not affected. In rats pretreated for 2 weeks with the angiotensin converting enzyme inhibitor enalapril, as well as in rats receiving the angiotensin II receptor antagonist losartan acutely, the nicardipine-induced increase in haematocrit was abolished. In enalapril-treated rats the increase in haematocrit was entirely restored when angiotensin II was infused at a subpressor dose. The nicardipine-induced decrease in arterial pressure was not affected by pharmacological blockade of the renin-angiotensin system. Conclusions These results demonstrate that the transcapillary shift of fluid induced by nicardipine is independent of ANP and requires the presence of a functional renin-angiotensin system, whereas its hypotensive action is independent of both ANP and angiotensin II.
Published: 1993
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46. Effect of monoclonal anti-ANP antibodies on the acute functional adaptation to unilateral nephrectomy

Author: Dominik Neuser, Jürg Nussberger, Albert Mimran, Jean-Pierre Valentin, and Jean Ribstein
Subjects: Male, medicine.medical_specialty, medicine.drug_class, medicine.medical_treatment, Blood Pressure, Endogeny, Monoclonal antibody, Nephrectomy, Rats, Sprague-Dawley, Atrial natriuretic peptide, Internal medicine, medicine, Animals, Kidney, biology, business.industry, Antibodies, Monoclonal, Unilateral nephrectomy, Adaptation, Physiological, Rats, Endocrinology, medicine.anatomical_structure, Nephrology, Monoclonal, cardiovascular system, biology.protein, Antibody, business, Atrial Natriuretic Factor, hormones, hormone substitutes, and hormone antagonists, circulatory and respiratory physiology
Abstract: Effect of monoclonal anti-ANP antibodies on the acute functional adaptation to unilateral nephrectomy. The role of endogenous atrial natriuretic peptide (ANP) in the immediate response of sodium excretion to unilateral nephrectomy (UNX) was investigated in anesthetized euvolemic rats through measurement of UNX-induced change in plasma ANP concentration and the response of the remaining kidney to UNX following administration of monoclonal anti-ANP antibodies. The circulating ANP levels almost tripled (from 23 ± 4 to 66 ± 13 fmol/ml, P < 0.01) within two minutes after UNX, whereas no change resulted from sham intervention. In the control group receiving vehicle injection, UNX resulted in a twofold increase in urinary sodium excretion (from 1.39 ± 0.25 to 2.88 ± 0.28 µmol/min, P < 0.01) related to a decrease in the fractional reabsorption of sodium at both proximal and distal sites (estimated from fractional excretion of lithium). Urinary excretion of cyclic guanosine 3′-5′-monophosphate (cGMP) increased as well, but glomerular filtration rate did not change. In addition, UNX was associated with a short-lived (
Published: 1993
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47. Tubular Site of the Natriuresis After Unilateral Nephrectomy in the Rat

Author: Jean-Pierre Valentin, Albert Mimran, and Jean Ribstein
Subjects: Male, medicine.medical_specialty, medicine.medical_treatment, Urinary system, Sodium, Natriuresis, Renal function, chemistry.chemical_element, Endogeny, Lithium, Kidney Function Tests, Nephrectomy, Kidney Tubules, Proximal, Rats, Sprague-Dawley, Atrial natriuretic peptide, Internal medicine, medicine, Animals, Kidney Tubules, Distal, Kidney, business.industry, Antibodies, Monoclonal, General Medicine, Rats, medicine.anatomical_structure, Endocrinology, chemistry, cardiovascular system, business, Atrial Natriuretic Factor
Abstract: Unilateral nephrectomy (UNX) is followed by a prompt increase in sodium excretion from the remaining kidney. Recently, an important role for atrial natriuretic peptide (ANP) in mediating the UNX-associated natriuresis has been suggested. The present studies were undertaken to gain insight into the intrarenal mechanisms participating in the post-UNX natriuresis in circumstances in which the release or the action of endogenous ANP were suppressed by prior removal of the right atrial appendage and by administration of monoclonal anti-ANP antibodies, respectively. In anesthetized euvolemic untreated rats, UNX resulted in a twofold increase in urinary excretion of sodium (from 0.93 +/- 0.23 to 2.14 +/- 0.34 microE/min; p0.03), whereas glomerular filtration rate did not change significantly. Fractional excretion of lithium, an index of proximal tubular handling of sodium, increased from 30.7 +/- 3.4% to 39.4 +/- 4.0%, and fractional distal reabsorption of sodium decreased from 98.6 +/- 0.2% to 96.5% +/- 0.4% (both p0.006). Neither sham atrial appendectomy nor the administration of nonspecific antibodies affect the natriuretic response of the remaining kidney. The natriuretic response to UNX was abolished in right atrial appendectomized rats, as well as in rats receiving anti-ANP antibodies. Post-UNX changes in both proximal and distal tubular reabsorption of sodium were also suppressed in these animals. These observations indicate that ANP may be an important mediator of the natriuretic response to UNX and that the proximal and the distal part of the nephron contribute to the postnephrectomy natriuresis.
Published: 1993
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48. Comparative Renal and Cardiac Effects of Tertatolol and Enalapril in Essential Hypertension

Author: Remi Brouard, Jean Ribstein, Albert Mimran, and Guilhem du Cailar
Subjects: Adult, Male, medicine.medical_specialty, Time Factors, Adrenergic beta-Antagonists, Renal function, Thiophenes, Kidney, Kidney Function Tests, Left ventricular hypertrophy, Essential hypertension, Propanolamines, Enalapril, Internal medicine, medicine, Humans, Pharmacology (medical), Cardiac structure, In patient, Antihypertensive Agents, business.industry, Hemodynamics, Middle Aged, medicine.disease, Tertatolol, Echocardiography, Pathophysiology of hypertension, Hypertension, Cardiology, Female, Hypertrophy, Left Ventricular, Cardiology and Cardiovascular Medicine, business, medicine.drug
Abstract: The influence of a 3-month antihypertensive treatment on cardiac structure and renal function was assessed in patients with uncomplicated essential hypertension randomly allocated to treatment by the nonselective beta-blocker tertatolol or the angiotensin-converting enzyme inhibitor enalapril. Both tertatolol and enalapril treatments were associated with a similar decrease in mean arterial pressure (-26 +/- 6 and -15 +/- 2 mm Hg, respectively, both p0.05 in comparison with baseline values) and left ventricular mass (echocardiography: -48 +/- 17 vs. -18 +/- 6 g) but no change in glomerular filtration rate (DTPA clearance). Renal vascular resistance decreased similarly in both groups. Urinary albumin excretion was not significantly modified in either group. These results indicate that a consistent reduction in arterial pressure by either treatment was associated with a proportional change in left ventricular geometry and no alteration in renal function.
Published: 1993
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49. Dietary sodium, aldosterone, and left ventricular mass changes during long-term inhibition of the renin-angiotensin system

Author: Jean Ribstein, Guilhem du Cailar, Albert Mimran, and Pierre Fesler
Subjects: Adult, Male, medicine.medical_specialty, Angiotensin receptor, medicine.drug_class, Angiotensin-Converting Enzyme Inhibitors, Blood Pressure, Left ventricular hypertrophy, Essential hypertension, Renin-Angiotensin System, chemistry.chemical_compound, Internal medicine, Renin–angiotensin system, Internal Medicine, medicine, Humans, Aldosterone, Antihypertensive Agents, Aged, Analysis of Variance, biology, business.industry, Angiotensin-converting enzyme, Sodium, Dietary, Middle Aged, medicine.disease, Endocrinology, Blood pressure, chemistry, Mineralocorticoid, Echocardiography, Hypertension, biology.protein, Cardiology, Linear Models, Female, Hypertrophy, Left Ventricular, business, Follow-Up Studies
Abstract: In essential hypertension, the regression of left ventricular hypertrophy is an important goal of treatment. In addition to treatment-associated changes in blood pressure (BP), the roles of other determinants of left ventricular hypertrophy regression, including dietary sodium intake, deserve investigation. In the present study, the change in echographic left ventricular mass index (LVMI) was assessed in 182 patients with never-treated essential hypertension at baseline and after 3 years of treatment by angiotensin converting enzyme inhibitors or angiotensin II receptor antagonists given at recommended doses and associated with other antihypertensive agents. Treatment was associated with satisfactory control of BP (
Published: 2010

50. Glomerular hemodynamics and arterial function in normal individuals

Author: Albert Mimran, Jean Ribstein, Guilhem du Cailar, and Pierre Fesler
Subjects: Adult, Male, medicine.medical_specialty, Mean arterial pressure, Physiology, Population, Hemodynamics, Renal function, Internal medicine, Internal Medicine, medicine, Humans, education, Pulse wave velocity, Aged, education.field_of_study, business.industry, Arteries, Middle Aged, medicine.disease, Filtration fraction, Reflection Magnitude, Endocrinology, Cardiology, Arterial stiffness, Female, Cardiology and Cardiovascular Medicine, business, Glomerular Filtration Rate
Abstract: Objective To determine the relationship between arterial function (stiffness and wave reflection) and glomerular hemodynamics. Methods In 49 healthy normotensive individuals, glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) were measured by urinary clearances of 99mTC-DTPA and 131I-hippuran, respectively. Filtration fraction was computed as GFR/ERPF. Arterial stiffness was estimated by carotid-femoral pulse wave velocity (PWV). Wave reflection was evaluated by carotid augmentation index (AIx), reflection magnitude and the round-trip travel time of the pressure wave. Results PWV and round-trip travel time were not independently correlated with any renal hemodynamic parameter or urinary albumin-creatinine ratio (UACR). AIx and reflection magnitude were directly correlated with filtration fraction (r = 0.35 and 0.37, respectively) and UACR (r = 0.43 and 0.53, respectively). When the population was divided into quartiles of reflection magnitude, filtration fraction and UACR progressively increased from the lowest to the highest quartile and after adjustment for age, mean arterial pressure, heart rate but also sex for UACR (P linear trend = 0.031 and 0.001, respectively). Conclusion It is suggested that in normal individuals, the amplitude of wave reflection but not arterial stiffness is associated with signs evocative of increased glomerular pressure (filtration fraction and UACR), independently of systemic blood pressure.
Published: 2010

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