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Your search keyword '"Jean Ernest Sohna Sohna"' showing total 7 results
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7 results on '"Jean Ernest Sohna Sohna"'

1. Photoactive pyrene-containing receptors for transition-metal ions

Author

Jean-Ernest Sohna Sohna, Tirapattur Soujanya, Stéphanie Leroy, and Frédéric Fages

Subjects
chemistry.chemical_compound, chemistry, General Chemical Engineering, Pyrene, General Chemistry, Chromophore, Photochemistry, Receptor, Fluorescence, Transition metal ions, Ion
Abstract

Photoresponsive molecular receptors based on the photophysical properties of the pyrene chromophore were designed to exhibit tunable fluorescence emission upon binding of transition-metal ions.

Published
2001
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2. Sensitized luminescence emission of the europium(III) ion bound to a pyrene-containing triacid ligand

Author

Jean-Ernest Sohna Sohna and Frédéric Fages

Subjects
Lanthanide, Ligand, Organic Chemistry, chemistry.chemical_element, Chromophore, Photochemistry, Biochemistry, Metal, chemistry.chemical_compound, chemistry, Excited state, visual_art, Drug Discovery, visual_art.visual_art_medium, Pyrene, Luminescence, Europium
Abstract

A pyrene-tethered triacid receptor and its chelates with two lanthanide(III) metal cations have been synthesized. The first example of energy transfer taking place from the excited pyrene chromophore to the europium(III) metal is reported therein.

Published
1997
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4. Peptide platforms for metal ion sensing

Author

Barbara Imperiali, Jean-Ernest Sohna Sohna, Alicia Torrado, Grant K. Walkup, Dierdre A. Pearce, Fallahi, Mahmoud, and Swanson, Basil I.

Subjects
Metal, chemistry.chemical_classification, chemistry, visual_art, visual_art.visual_art_medium, Molecule, Nanotechnology, Peptide, Fluorescence
Abstract

Naturally occurring motifs have been redesigned to product fluorescent peptidyl-chemosensors that sensitively and selectively recognize Cu(II) or Fe(III). The modular nature of peptide architecture allows preparation and evaluation of potential sensors on solid supports.

Published
1999

5. Zinc(II)-driven Fluorescence Quenching of a Pyrene-labelled Bis-2,2′-bipyridine Ligand

Author

Jean-Ernest Sohna Sohna, Pascale Jaumier, and Frédéric Fages

Subjects
Quenching (fluorescence), Chemistry, Ligand, 010405 organic chemistry, chemistry.chemical_element, Zinc, General Chemistry, Photochemistry, 010402 general chemistry, Fluorescence, 01 natural sciences, 2,2'-Bipyridine, 0104 chemical sciences, chemistry.chemical_compound, Pyrene, Methanol
Abstract

The title compound has been synthesized and its fluorescence emission is quenched upon complexation of the Zn2+ in methanol solution.

Published
1999
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6. A trisbipyridine tripodal ligand as toluene gelator. Phase transition-triggered binding of iron(ii)

Author

Frédéric Fages and Jean-Ernest Sohna Sohna

Subjects
Phase transition, Ligand, Binding properties, Metals and Alloys, General Chemistry, Photochemistry, Toluene, Catalysis, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, chemistry.chemical_compound, chemistry, Tripodal ligand, Materials Chemistry, Ceramics and Composites
Abstract

The formation of a physical gel with toluene is reported for a trisbipyridine ligand which exhibits iron(II) binding properties triggered by the gel-to-liquid phase transition.

Published
1997
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7. Accurate whole human genome sequencing using reversible terminator chemistry

Author

Zoya Kingsbury, Marc Laurent, Jason Bryant, Konstantinos D. Diakoumakos, Klaus Maisinger, Louise Fraser, Jean Ernest Sohna Sohna, Adrian Horgan, Patrick Mccauley, Jane Rogers, David W. Elmore, Mark A. Osborne, Juying Yan, Mark Smith, Milan Fedurco, Gary P. Schroth, Belen Dominguez-Fernandez, Heng Li, Andrea Sabot, Suzanne Wakelin, Cindy Lawley, Carole Anastasi, David Klenerman, David George, Daniel P. Pliskin, Mohammed D. Alam, Svilen S. Tzonev, Mark T. Reed, Xiaohai Liu, Asha Boodhun, Lu Zhang, Aylwyn Scally, T. A. Huw Jones, Ugonna C. Egbujor, Tzvetana H. Kerelska, George Stefan Golda, Shankar Balasubramanian, Lukasz Szajkowski, Mitch Lok, Mitch K. Shiver, Paul McNitt, Simon Chang, Maria Q. Johnson, Gyoung-Dong Kang, Victor J. Quijano, Sarah E. Lee, Mike Zuerlein, Maria Candelaria Rogert Bacigalupo, Alan D. Kersey, Selena G. Barbour, Dirk J. Evers, Andrew C. Pike, Stephen Rawlings, Karin Fuentes Fajardo, Mirian S. Karbelashvili, Matthew E. Hurles, Sonia M. Novo, Xavier Lee, James C. Burrows, John Stephen West, Jingwen Wang, Ify C. Aniebo, Natasha R. Crake, Christian D. Haudenschild, Richard Shaw, Come Raczy, W. Scott Furey, Wu Xiaolin, Lambros L. Paraschos, Josefina M. Seoane, John W. Martin, Katya Hoschler, Raquel Maria Sanches-Kuiper, Nick J. McCooke, Colin Barnes, Johannes P. Sluis, Abass A. Bundu, John Milton, R. Keira Cheetham, Nancy F. Hansen, Clive Gavin Brown, Nigel P. Carter, Richard J. Carter, Chiara Rodighiero, Kim B. Stevens, Shujun Luo, Radhika M. Mammen, Phyllida M. Roe, Melanie Anne Smith, Bojan Obradovic, Johnny T. Ho, Jennifer A. Loch, Terena James, Harold Swerdlow, Dale Buermann, David E. Green, Steve Hurwitz, Joe W. Mullens, Ning Sizto, Frank L. Oaks, Eli Rusman, Natalie J. Rourke, Nikolai Romanov, Anthony J. Smith, Claire Bevis, Selene M. Virk, Ling Yau, Yuli Verhovsky, D. Chris Pinkard, Stephanie Vandevondele, Vincent Peter Smith, Rob C. Brown, Eric J. Spence, Joe Podhasky, Ana Chiva Rodriguez, Michael Lawrence Parkinson, Anthony Romieu, Joe S. Brennan, Rithy K. Roth, David Mark Dunstan Bailey, Roberto Rigatti, Anil Kumar, Phillip J. Black, Primo Baybayan, Saibal Banerjee, Matthew M. Hims, Arnold Liao, R. Neil Cooley, Omead Ostadan, Vincent A. Benoit, Andrew A. Brown, Silke Ruediger, Leslie J. Irving, Parul Mehta, James C. Mullikin, Klaudia Walter, John Rogers, Jonathan Mark Boutell, Alex P. Kindwall, Paula Kokko-Gonzales, Alger C. Pike, Michael J. O'Neill, Eric Vermaas, Subramanian V. Sankar, Sean Humphray, Steven W. Short, Gerardo Turcatti, Helen Bignell, Kimberley J. Gietzen, Peta E. Torrance, Narinder I. Heyer, David James Earnshaw, Kevin Hall, Martin R. Schenker, Richard Durbin, Philip A. Granieri, Tobias William Barr Ost, Iain R. Bancarz, Lea Pickering, David L. Gustafson, Peter Lundberg, Niall Anthony Gormley, John Bridgham, Andrew Osnowski, Scott M. Kirk, Mark R. Ewan, Keith W. Moon, Bee Ling Ng, Graham John Worsley, Anthony J. Cox, Olubunmi O. Dada, Gregory C. Walcott, Sergey Etchin, Irina Khrebtukova, Kevin Benson, Vicki H. Rae, Zemin Ning, Carolyn Tregidgo, Nestor Castillo, Colin P. Goddard, Taksina Newington, Denis V. Ivanov, Anastassia Spiridou, Maria Chiara E. Catenazzi, Neil Sutton, Kevin Harnish, Darren James Ellis, Lisa Murray, Geoffrey Paul Smith, Mark T. Ross, David R. Bentley, M. R. Pratt, Isabelle Rasolonjatovo, and Michael R. Flatbush

Subjects
Male, Genotype, 2 base encoding, Nigeria, Sequence assembly, Hybrid genome assembly, Genomics, Computational biology, Biology, Polymorphism, Single Nucleotide, Sensitivity and Specificity, Deep sequencing, Article, 03 medical and health sciences, 0302 clinical medicine, Consensus Sequence, Humans, Paired-end tag, 030304 developmental biology, Genetics, Whole genome sequencing, Chromosomes, Human, X, 0303 health sciences, Multidisciplinary, Genome, Human, DNA sequencing theory, Sequence Analysis, DNA, 030220 oncology & carcinogenesis
Abstract

DNA sequence information underpins genetic research, enabling discoveries of important biological or medical benefit. Sequencing projects have traditionally used long (400-800 base pair) reads, but the existence of reference sequences for the human and many other genomes makes it possible to develop new, fast approaches to re-sequencing, whereby shorter reads are compared to a reference to identify intraspecies genetic variation. Here we report an approach that generates several billion bases of accurate nucleotide sequence per experiment at low cost. Single molecules of DNA are attached to a flat surface, amplified in situ and used as templates for synthetic sequencing with fluorescent reversible terminator deoxyribonucleotides. Images of the surface are analysed to generate high-quality sequence. We demonstrate application of this approach to human genome sequencing on flow-sorted X chromosomes and then scale the approach to determine the genome sequence of a male Yoruba from Ibadan, Nigeria. We build an accurate consensus sequence from >30x average depth of paired 35-base reads. We characterize four million single-nucleotide polymorphisms and four hundred thousand structural variants, many of which were previously unknown. Our approach is effective for accurate, rapid and economical whole-genome re-sequencing and many other biomedical applications.

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