2,356 results on '"Jean, Raymond A."'
Search Results
2. Endovascular Therapy in the Extended Time Window for Large Vessel Occlusion in Patients With Pre-Stroke Disability
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Kanta Tanaka, Hiroshi Yamagami, Muhammad M. Qureshi, Kazutaka Uchida, James E. Siegler, Raul G. Nogueira, Shinichi Yoshimura, Nobuyuki Sakai, Nicolas Martinez-Majander, Simon Nagel, Jelle Demeestere, Volker Puetz, Diogo C. Haussen, Mohamad Abdalkader, Marta Olive-Gadea, Mahmoud H. Mohammaden, João Pedro Marto, Anne Dusart, Simon Winzer, Liisa Tomppo, Francois Caparros, Hilde Henon, Flavio Bellante, João Nuno Ramos, Santiago Ortega-Gutierrez, Sunil A. Sheth, Stefania Nannoni, Johannes Kaesmacher, Lieselotte Vandewalle, Sergio Salazar-Marioni, Mudassir Farooqui, Pekka Virtanen, Rita Ventura, Syed Zaidi, Alicia C. Castonguay, Ajit S. Puri, Behzad Farzin, Hesham E. Masoud, Piers Klein, Jessica Jesser, Manuel Requena, Tomas Dobrocky, Daniel P.O. Kaiser, Erno Peltola, Davide Strambo, Markus A. Möhlenbruch, Eugene Lin, Peter A. Ringleb, Osama O. Zaidat, Charlotte Cordonnier, Daniel Roy, Robin Lemmens, Marc Ribo, Daniel Strbian, Urs Fischer, Patrik Michel, Jean Raymond, and Thanh N. Nguyen
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activities of daily living ,ischemic stroke ,endovascular therapy ,reperfusion ,outcome ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background and Purpose We compared the outcomes of endovascular therapy (EVT) in an extended time window in patients with large-vessel occlusion (LVO) between patients with and without pre-stroke disability. Methods In this prespecified analysis of the multinational CT for Late Endovascular Reperfusion study (66 participating sites, 10 countries between 2014 and 2022), we analyzed data from patients with acute ischemic stroke with a pre-stroke modified Rankin Scale (mRS) score of 0–4 and LVO who underwent EVT 6–24 hours from the time last seen well. The primary outcome was the composite of functional independence (FI; mRS score 0–2) or return to the pre-stroke mRS score (return of Rankin, RoR) at 90 days. Outcomes were compared between patients with pre-stroke disability (pre-stroke mRS score 2–4) and those without (mRS score 0–1). Results A total of 2,231 patients (median age, 72 years; median National Institutes of Health Stroke Scale score, 16) were included in the present analysis. Of these, 564 (25%) had pre-stroke disability. The primary outcome (FI or RoR) was observed in 30.7% of patients with pre-stroke disability (FI, 16.5%; RoR, 30.7%) compared to 44.1% of patients without (FI, 44.1%; RoR, 13.0%) (P
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- 2024
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3. List of contributors
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Barbariol, Francesco, primary, Benetazzo, Alvise, additional, Bergamasco, Filippo, additional, Bidlot, Jean-Raymond, additional, Bitner-Gregersen, Elzbieta M., additional, Chabchoub, Amin, additional, Christou, Marios, additional, Doong, Dong-Jiing, additional, Ewans, Kevin, additional, Houtani, Hidetaka, additional, Ilic, Suzana, additional, Kashima, Hiroaki, additional, Luxmoore, Jamie, additional, Lyu, Zuorui, additional, Mori, Nobuhito, additional, Terng, Chuen-Teyr, additional, Tsai, Cheng-Han, additional, and Waseda, Takuji, additional
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- 2024
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4. CLEAR Thrombectomy Score: An Index to Estimate the Probability of Good Functional Outcome With or Without Endovascular Treatment in the Late Window for Anterior Circulation Occlusion
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James E. Siegler, Manisha Koneru, Muhammad M. Qureshi, Mohamed Doheim, Raul G. Nogueira, Nicolas Martinez‐Majander, Simon Nagel, Mary Penckofer, Jelle Demeestere, Volker Puetz, Marc Ribo, Mohamad Abdalkader, João Pedro Marto, Alhamza R. Al‐Bayati, Hiroshi Yamagami, Diogo C. Haussen, Marta Olive‐Gadea, Simon Winzer, Mahmoud H. Mohammaden, Robin Lemmens, Kanta Tanaka, Pekka Virtanen, Anne Dusart, Flavio Bellante, Daniel P. O. Kaiser, Francois Caparros, Hilde Henon, João Nuno Ramos, Santiago Ortega‐Gutierrez, Sunil A. Sheth, Stefania Nannoni, Lieselotte Vandewalle, Johannes Kaesmacher, Sergio Salazar‐Marioni, Liisa Tomppo, Rita Ventura, Syed F. Zaidi, Mouhammad Jumaa, Alicia C. Castonguay, Milagros Galecio‐Castillo, Ajit S. Puri, Adnan Mujanovic, Piers Klein, Liqi Shu, Behzad Farzin, Hannah Moomey, Hesham E. Masoud, Jessica Jesser, Markus A. Möhlenbruch, Peter A. Ringleb, Daniel Strbian, Osama O. Zaidat, Shadi Yaghi, Davide Strambo, Patrik Michel, Daniel Roy, Shinichi Yoshimura, Kazutaka Uchida, Jean Raymond, and Thanh N. Nguyen
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acute stroke ,endovascular therapy ,late window ,prognosis ,score ,thrombectomy ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background With the expanding eligibility for endovascular therapy (EVT) of patients presenting in the late window (6–24 hours after last known well), we aimed to derive a score to predict favorable outcomes associated with EVT versus best medical management. Methods and Results A multinational observational cohort of patients from the CLEAR (Computed Tomography for Late Endovascular Reperfusion) study with proximal intracranial occlusion (2014–2022) was queried (n=58 sites). Logistic regression analyses were used to derive a 9‐point score for predicting good functional outcome (modified Rankin Scale score 0–2 or return to premorbid modified Rankin Scale score) at 90 days, with sensitivity analyses for prespecified subgroups conducted using bootstrapped random forest regressions. Secondary outcomes included 90‐day functional independence (modified Rankin Scale score 0–2), poor outcome (modified Rankin Scale score 5–6), and 90‐day survival. The score was externally validated with a single‐center cohort (2014–2023). Of the 3231 included patients (n=2499 EVT), a 9‐point score included age, early computed tomography ischemic changes, and stroke severity, with higher points indicating a higher probability of a good functional outcome. The areas under the curve for the primary outcome among EVT and best medical management subgroups were 0.72 (95% CI, 0.70–0.74) and 0.87 (95% CI, 0.84–0.90), respectively, with similar performance in the external validation cohort (area under the curve, 0.71 [95% CI, 0.66–0.76]). There was a significant interaction between the score and EVT for good functional outcome, functional independence, and poor outcome (all Pinteraction
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- 2024
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5. The North Equatorial Current and rapid intensification of super typhoons
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Sok Kuh Kang, Sung-Hun Kim, I.-I. Lin, Young-Hyang Park, Yumi Choi, Isaac Ginis, Joseph Cione, Ji Yun Shin, Eun Jin Kim, Kyeong Ok Kim, Hyoun Woo Kang, Jae-Hyoung Park, Jean-Raymond Bidlot, and Brian Ward
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Science - Abstract
Abstract Super Typhoon Mangkhut, which traversed the North Equatorial Current (NEC; 8–17 °N) in the western North Pacific in 2018, was the most intense Category-5 tropical cyclone (TC) with the longest duration in history—3.5 days. Here we show that the combination of two factors—high ocean heat content (OHC) and increased stratification — makes the NEC region the most favored area for a rapid intensification (RI) of super typhoons, instead of the Eddy Rich Zone (17–25 °N), which was considered the most relevant for RI occurrence. The high OHC results from a northward deepening thermocline in geostrophic balance with the westward-flowing NEC. The stratification is derived from precipitation associated with the Inter-Tropical Convergence Zone in the summer peak typhoon season. These factors, which are increasingly significant over the past four decades, impede the TC-induced sea surface cooling, thus enhancing RI of TCs and simultaneously maintaining super typhoons over the NEC region.
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- 2024
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6. Global coastal wave storminess
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Hector Lobeto, Alvaro Semedo, Gil Lemos, Ali Dastgheib, Melisa Menendez, Roshanka Ranasinghe, and Jean-Raymond Bidlot
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Medicine ,Science - Abstract
Abstract Coastal wave storms pose a massive threat to over 10% of the world’s population now inhabiting the low elevation coastal zone and to the trillions of $ worth of coastal zone infrastructure and developments therein. Using a ~ 40-year wave hindcast, we here present a world-first assessment of wind-wave storminess along the global coastline. Coastal regions are ranked in terms of the main storm characteristics, showing Northwestern Europe and Southwestern South America to suffer, on average, the most intense storms and the Yellow Sea coast and the South-African and Namibian coasts to be impacted by the most frequent storms. These characteristics are then combined to derive a holistic classification of the global coastlines in terms of their wave environment, showing, for example, that the open coasts of northwestern Europe are impacted by more than 10 storms per year with mean significant wave heights over 6 m. Finally, a novel metric to classify the degree of coastal wave storminess is presented, showing a general latitudinal storminess gradient. Iceland, Ireland, Scotland, Chile and Australia show the highest degree of storminess, whereas Indonesia, Papua-New Guinea, Malaysia, Cambodia and Myanmar show the lowest.
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- 2024
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7. Association of timing and agent for VTE prophylaxis in patients with severe traumatic brain injury on VTE, mortality, neurosurgical intervention, and discharge disposition
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Johnson, Patrick L., Dualeh, Shukri H. A., Ward, Ayobami, Jean, Raymond A., Aubry, Staci, Chapman, Alistair, Curtiss, William, Joseph, Jacob, Scott, John W., and Hemmila, Mark R.
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- 2024
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8. The Impact of a Reduced High-wind Charnock Parameter on Wave Growth With Application to the North Sea, the Norwegian Sea and the Arctic Ocean
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Breivik, Øyvind, Carrasco, Ana, Haakenstad, Hilde, Aarnes, Ole Johan, Behrens, Arno, Bidlot, Jean-Raymond, Björkqvist, Jan-Victor, Bohlinger, Patrik, Furevik, Birgitte R, Staneva, Joanna, and Reistad, Magnar
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Physics - Atmospheric and Oceanic Physics - Abstract
As atmospheric models move to higher resolution and resolve smaller scales, the maximum modeled wind speed also tends to increase. Wave models tuned to coarser wind fields tend to overestimate the wave growth under strong winds. A recently developed semi-empirical parameterization of the Charnock parameter, which controls the roughness length over surface waves, substantially reduces the aerodynamic drag of waves in high winds (above a threshold of 30 m/s). Here we apply the formulation in a recent version of the wave model WAM (Cycle 4.7), which uses a modified version of the physics parameterizations by Ardhuin et al (2010) as well as subgrid obstructions for better performance around complex topography. The new Charnock formulation is tested with wind forcing from NORA3, a recently completed non-hydrostatic atmospheric downscaling of the global reanalysis ERA5 for the North Sea, the Norwegian Sea and the Barents Sea. Such high-resolution atmospheric model integrations tend to have stronger (and more realistic) upper-percentile winds than what is typically found in coarser atmospheric models. A two-year comparison (2011-2012) of a control run against the run with the modified Charnock parameter shows a dramatic reduction of the wave height bias in high-wind cases. The added computational cost of the new physics and the reduction of the Charnock parameter compared to the earlier WAM physics is modest (14%). A longer (1998-2020) hindcast integration with the new Charnock parameter is found to compare well against in situ and altimeter wave measurements both for intermediate and high sea states., Comment: 38 pages, 9 figures plus 5 appendix figures
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- 2022
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9. Characterization of a composite based on Cissus dinklagei tannin resin
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Abel Emmanuel Njom, Joseph Voufo, Cesar Segovia, Noël Konai, Armel Mewoli, Leonnel Karga Tapsia, Jean Raymond Lucien Meva'a, and Antonio Pizzi
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Cissus dinklagei tannin ,Adhesive ,Particleboard ,Thermomechanics ,Resins ,Composite materials ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
The tannin extract of Cissus dinklagei was used in the preparation of a 3 % paraformaldehyde resin for the manufacture of particleboard. This tannin is of the procyanidin type associated with furan residues. The modulus of elasticity of the resin obtained after the thermomechanical analysis is 3825 MPa. The TGA performed on the panels obtained shows three degradation zones with a thermal stability zone between 74 and 210 °C. These panels have good thermomechanical properties. The values of the best density, internal bond, modulus of elasticity in flexion (MOE) and resistance to flexion (MOR) are respectively 658 kg/m3; 0.52 MPa; 2035.4 MPa; 16.3 MPa. These results classify this panel for generalinterior construction and furniture uses according to the NF EN 312 standard.
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- 2024
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10. Characterization of a composite based on Cissus dinklagei tannin resin
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Njom, Abel Emmanuel, Voufo, Joseph, Segovia, Cesar, Konai, Noël, Mewoli, Armel, Tapsia, Leonnel Karga, Meva'a, Jean Raymond Lucien, and Pizzi, Antonio
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- 2024
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11. Correction to: Satellite Remote Sensing of Surface Winds, Waves, and Currents: Where are we Now?
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Hauser, Danièle, Abdalla, Saleh, Ardhuin, Fabrice, Bidlot, Jean-Raymond, Bourassa, Mark, Cotton, David, Gommenginger, Christine, Evers-King, Hayley, Johnsen, Harald, Knaff, John, Lavender, Samantha, Mouche, Alexis, Reul, Nicolas, Sampson, Charles, Steele, Edward C.C, and Stoffelen, Ad
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- 2023
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12. Satellite Remote Sensing of Surface Winds, Waves, and Currents: Where are we Now?
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Hauser, Danièle, Abdalla, Saleh, Ardhuin, Fabrice, Bidlot, Jean-Raymond, Bourassa, Mark, Cotton, David, Gommenginger, Christine, Evers-King, Hayley, Johnsen, Harald, Knaff, John, Lavender, Samantha, Mouche, Alexis, Reul, Nicolas, Sampson, Charles, Steele, Edward C.C, and Stoffelen, Ad
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- 2023
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13. The small trial problem
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Jean Raymond, Tim E. Darsaut, Johanna Eneling, and Miguel Chagnon
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Trial size ,Sample size ,Number of patients ,Trial methodology ,Problems with continuous variables ,Dichotomization ,Medicine (General) ,R5-920 - Abstract
Abstract Background Many randomized trials that aim to assess new or commonly used medical or surgical interventions have been so small that the validity of conclusions becomes questionable. Methods We illustrate the small trial problem using the power calculation of five Cochrane-reviewed studies that compared vertebroplasty versus placebo interventions. We discuss some of the reasons why the statistical admonition not to dichotomize continuous variables may not apply to the calculation of the number of patients required for trials to be meaningful. Results Placebo–controlled vertebroplasty trials planned to recruit between 23 and 71 patients per group. Four of five studies used the standardized mean difference of a continuous pain variable (centimeters on the visual analog scale (VAS)) to plan implausibly small trials. What is needed is not a mean effect at the population level but a measure of efficacy at the patient level. Clinical practice concerns the care of individual patients that vary in many more respects than the variation around the mean of a single selected variable. The inference from trial to practice concerns the frequency of success of the experimental intervention performed one patient at a time. A comparison of the proportions of patients reaching a certain threshold is a more meaningful method that appropriately requires larger trials. Conclusion Most placebo-controlled vertebroplasty trials used comparisons of means of a continuous variable and were consequently very small. Randomized trials should instead be large enough to account for the diversity of future patients and practices. They should offer an evaluation of a clinically meaningful number of interventions performed in various contexts. Implications of this principle are not specific to placebo-controlled surgical trials. Trials designed to inform practice require a per-patient comparison of outcomes and the size of the trial should be planned accordingly.
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- 2023
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14. Functional characterisation of the FIKK kinase family of Plasmodium falciparum
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Belda, Hugo Marie Jean-Raymond, Treeck, Moritz, and Tate, Edward
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Key to P. falciparum virulence is its capacity to remodel the host erythrocyte. Infected erythrocytes become rigid and cytoadhere to the vascular endothelium leading to the disease symptoms and preventing their filtration by the spleen. Unlike other human- infecting Plasmodium species, P. falciparum exports a family of 18 FIKK kinases into the host cell. Here, a conditional knockout strategy based on the DiCre/LoxPint technology was used to study 4 FIKK kinases (FIKK4.1, FIKK7.1, FIKK10.1 and FIKK11) and identify their potential targets by quantitative phosphoproteome analysis. The deletion of FIKK4.1 led to a significant reduction in the phosphorylation of host cytoskeletal proteins and parasite proteins involved in remodelling. The characterisation of FIKK4.1 KO parasites confirmed its role both in the rigidification of the infected erythrocytes and in the trafficking of the adherence-mediating virulence factor PfEMP1 to the host cell surface. Additionally, recombinant versions of several FIKK kinase domains were used to identify potential pan-FIKK inhibitors. When tested in vitro, these compounds showed activity on both P. falciparum and P. knowlesi, raising concerns regarding their specificity. A whole genome sequencing on drug-resistant parasites did not allow to identify additional targets. Moreover, it was shown that the compounds were not active on the FIKK kinases in culture due to the high intra-erythrocytic ATP concentration. Using the recombinant FIKK kinase domains it was also shown that FIKK kinases possess distinct substrate specificity. Whereas most of them conserved the ancestral basophilicity, some evolved to phosphorylate preferentially acidic motifs. Strikingly, FIKK13 was found to be a tyrosine kinase, a feature supposed to be absent in Plasmodium. Finally, by studying the FIKK kinases from another Plasmodium species closely related to P. falciparum, it was shown that FIKK kinases substrate specificity is conserved across species of the Laverania clade.
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- 2021
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15. Influence of the Extraction Location on the Physical and Mechanical Properties of the Pseudo-Trunk Banana Fibers
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Laurent Libog, Florent Biyeme, Achille Désiré Omgba Betené, Achille Bernard Biwolé, Benoit Ndiwe, Jonas Peequeur Essome Mbang, Takoumbe Claude, Jean Aimé Mbey, and Jean Raymond Lucien Meva’a
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pseudo-trunks ,banana fibers ,dispersion of properties ,statistical analyses ,mechanical properties ,anova ,Science ,Textile bleaching, dyeing, printing, etc. ,TP890-933 - Abstract
The specific properties and availability of banana pseudo-trunk fibers make them a promising alternative for the development of green composites. However, the wide dispersion of their properties can hinder their use. In this study, the influence of the sampling area of the banana pseudo-trunk on the physical and mechanical properties of the fibers was evaluated. Prior to retting, the trunk was sampled longitudinally (bottom, middle and top) and transversely (periphery, intermediate and heart). Gravimetric tests were carried out and revealed variations in water absorption (347.1–517.4%), density (0.92–1.45 g.cm−3) and linear mass (25 -34tex). Tensile tests were also performed and showed a significant effect of fiber location on Young’s modulus (6.60–34.6GPa), tensile strength (91-350MPa) and elongation at the break (0.9–2.6%). Due to diameter scatter, variations of 42% were found for fibers in the same area. In a region, the physical properties increase from the periphery to the core, and the mechanical properties decrease in the same direction, except for elongation. The results of this study showed good agreement with those of other natural fiber types. However, we recommend the peripheral areas of the pseudo-trunk to extract reinforcing fibers from composites because of their low density (0.9 g.cm−3) and their high stiffness (34GPa).
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- 2023
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16. An analytical model for analyzing the value of information flow in the production chain model using regression algorithms and neural networks
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Biyeme, Florent, Mbakop, André Marie, Chana, Anne Marie, Voufo, Joseph, and Meva'a, Jean Raymond Lucien
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- 2023
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17. An analytical model for analyzing the value of information flow in the production chain model using regression algorithms and neural networks
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Florent Biyeme, André Marie Mbakop, Anne Marie Chana, Joseph Voufo, and Jean Raymond Lucien Meva'a
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Artificial neural network ,Information flow management ,Regression algorithms ,Value of information ,Production chain model ,Marketing. Distribution of products ,HF5410-5417.5 ,Management. Industrial management ,HD28-70 - Abstract
Managing information flow has always been a challenging and critical driver of performance increase in manufacturing companies. Each bit of information related to the manufacturing process has an information flow value that can impact the process. Recent studies have focused on the traditional classification algorithms methods to analyze the value of information flow. In this research paper, we use regression algorithms to develop an analytics model for the value of information flow in manufacturing shop floors of developing countries. The analysis shows that the Artificial Neural Network (ANN) has the best regression coefficient score of 0.775 with a prediction error of 0.0125. The lowest regression coefficient score of 0.323 was for the Multi-Linear Regression (MLR) with a prediction error of 0.0556. These results help companies use regression algorithms effectively to analyze the value of information flows on the manufacturing chains.
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- 2023
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18. Méningoencéphalite à cryptocoque chez une patiente immunocompétente : rapport de cas et revue de la littérature
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Moussavou, Cédrick, primary, Biyie, Prudence, additional, Mbougou Mbina, Arthur Kevin, additional, Litchangou, Fred, additional, Keddy Nzondo, Max Léandre, additional, Mangouka, Laurette, additional, and Nzenze, Jean Raymond, additional
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- 2024
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19. Moving to a Flexible Shop Floor by Analyzing the Information Flow Coming from Levels of Decision on the Shop Floor of Developing Countries Using Artificial Neural Network: Cameroon, Case Study
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Mbakop, André Marie, Voufo, Joseph, Biyeme, Florent, and Meva’a, Jean Raymond Lucien
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- 2022
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20. A review about w{\'u}stite Fe 1-z O, pseudo-phases and defect clustering
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Gavarri, Jean-Raymond and Carel, Claude
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Condensed Matter - Materials Science - Abstract
Thermodynamic properties and structural aspects of the non-stoichiometric w\"ustite Fe 1-z O, and its modifications-the so-called pseudo-phases-as functions of composition z and equilibrium temperature are reviewed from 1960 to present (159 references). The focus is first put on the complexity of the equilibrium phase diagram. The first order transition W $\rightleftharpoons$ W' is specified on the boundary iron/ w\"ustite close to 1185 K. Transitions correlated to the modifications Wi at T(W) > 1185 K and W'j at 1185K < T(W') < T(W) (i and j =1,2,3) are reexamined. Structural determinations based on point defects and their clustering are recalled. A series of equilibria are developed, trying to justify the stabilization of the pseudo-phases, which can be interpreted in terms of transformation of defect clusters, or their mode of distribution (percolation, superstructure) including changes in electronic charge carriers., Comment: Article de revue
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- 2017
21. Pragmatic trials can address diagnostic controversies: recent lessons from gestational diabetes
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Jean Raymond, Hélène Long, and Tim Darsaut
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Diagnostic studies ,Pragmatic clinical trials ,Research ethics ,Gestational diabetes ,Medicine (General) ,R5-920 - Abstract
Abstract Objective The aim of the paper is to discuss how a pragmatic definition could change our conception of diagnosis, using gestational diabetes mellitus (GDM) as an example. Study design We review the diagnostic controversy that followed an observational study showing a linear relationship between maternal glycaemia and adverse pregnancy outcomes and the resolution proposed 15 years later by a recent pragmatic trial comparing two screening approaches (one- vs two-step) with different diagnostic thresholds. Results The pragmatic trial involved approximately 24,000 women. The one-step screening strategy using lower GDM thresholds diagnosed twice as many women with GDM, but pregnancy outcomes were not different. We examine how the pragmatic approach integrates research into practice and defines the meaning of a diagnosis according to patient outcomes. The approach is ethically and scientifically sound as compared to the previous methodology, where observational research separated from care gave a theoretical definition of GDM that may have misled medical practice for two decades. Conclusion Pragmatic research integrated into practice can revolutionize our conception of medical diagnosis in the best medical interest of patients.
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- 2022
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22. Structural, vibrational and luminescence properties of solid solution based on the (1-x/2) Ce2(WO4)3 + (x/2) Sm2(WO4)3 system
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Derraji, Kaouther, Favotto, Claude, Valmalette, Jean-Christophe, Villain, Sylvie, Nolibe, Gilles, Lyoussi, Abdallah, Guinneton, Frederic, and Gavarri, Jean-Raymond
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- 2022
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23. Abstract Number ‐ 6: Basilar Artery Occlusion Thrombectomy Technique: An International Survey of Practice Patterns
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Piers Klein, Ana Herning, Brian Drumm, Jean Raymond, Mohamad Abdalkader, Anurag Sahoo, James E Siegler, Yimin Chen, Xiaochuan Huo, Wouter J Schonewille, Xinfeng Liu, Wei Hu, Xunming Ji, Bertrand Lapergue, Chuanhui Li, Fana Alemseged, Daniel Strbian, Urs Fischer, Johannes Kaesmacher, Hiroshi Yamagami, Volker Puetz, Simona Sacco, Espen Saxhaug Kristoffersen, Jelle Demeestere, Kyriakos Lobotesis, Kubilay Aydin, Francesco Diana, Hesham E Masoud, Alice Ma, Roberta Novakovic‐White, Fawaz Al‐Mufti, Mai Duy Ton, Jean Christophe Gentric, Jildaz Caroff, Marios‐Nikos Psychogios, Lukas Meyer, Jens Fiehler, Joey English, Rishi Gupta, Bernard Yan, Bruce Campbell, Ashutosh P Jadhav, Jin Soo Lee, Götz Thomalla, Simon Nagel, Osama O Zaidat, Zhongming Qiu, Zhongrong Miao, Soma Banerjee, and Thanh N Nguyen
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Neurology. Diseases of the nervous system ,RC346-429 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Introduction Two recent trials demonstrated a benefit for endovascular thrombectomy (EVT) in the treatment of basilar artery occlusion (BAO). Considering the expected increase in the utilization of EVT for BAO, we sought to understand the technique preferences of neurointerventionalists currently performing EVT for BAO. Methods We conducted an international online survey of physician opinions on the use of EVT in BAO between January to March 2022. The survey was distributed through stroke and neurointerventional organizations. Survey questions examined selection of patients for the procedure and the techniques currently used for EVT in BAO. Results More than 3,000 participants were invited yielding 1,245 respondents, of which 543 were classified as neurointerventionalists across 52 countries and included in this analysis. Most neurointerventionalists would proceed to EVT for occlusions of the V4 segment, the basilar artery, or the PCA, without regard for prior IVT. For BAO of embolic etiology, aspiration only thrombectomy was the preferred method with 50.3% of neurointerventionalists. For BAO of intracranial atherosclerotic disease (ICAD) etiology, combined stent retriever and aspiration thrombectomy was the preferred method with 40.5% of neurointerventionalists (Figure 1). The majority of neurointerventionalists (88.0%) would proceed to stenting after three or fewer failed passes for patients with BAO of ICAD etiology. In patients undergoing stenting, aspirin and clopidogrel was the most common antiplatelet regime (52.4%). Conclusions Amongst the surveyed neurointerventionalists, the most common techniques for EVT of patients with BAO were contact aspiration or combined stent retriever with aspiration thrombectomy. For patients with BAO due to ICAD, the majority of neurointerventionalists were willing to stent and do so most often after three or fewer failed passes and with the use of dual antiplatelet medications. Further study is needed to determine the optimal technique for EVT of BAO with or without ICAD.
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- 2023
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24. Basilar Artery Occlusion Thrombectomy Technique: An International Survey of Practice Patterns†
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Piers Klein, Ana Herning, Brian Drumm, Jean Raymond, Mohamad Abdalkader, James E. Siegler, Yimin Chen, Xiaochuan Huo, Wouter J. Schonewille, Xinfeng Liu, Wei Hu, Xunming Ji, Bertrand Lapergue, Chuanhui Li, Fana Alemseged, Daniel Strbian, Urs Fischer, Johannes Kaesmacher, Hiroshi Yamagami, Volker Puetz, Simona Sacco, Espen Saxhaug Kristoffersen, Jelle Demeestere, Kyriakos Lobotesis, Dylan Roi, Kubilay Aydin, Francesco Diana, Hesham E. Masoud, Alice Ma, Roberta Novakovic‐White, Fawaz Al‐Mufti, Yuyou Zhu, Hongfei Sang, Dapeng Sun, Thang Huy Nguyen, Mai Duy Ton, Jean‐Christophe Gentric, Jildaz Caroff, Marios‐Nikos Psychogios, Arturo Consoli, Lukas Meyer, Jens Fiehler, Joey English, Rishi Gupta, Bernard Yan, Bruce Campbell, Ashutosh P. Jadhav, Jin Soo Lee, Götz Thomalla, Simon Nagel, Qingwu Yang, Osama O. Zaidat, Zhongming Qiu, Zhongrong Miao, Soma Banerjee, and Thanh N. Nguyen
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basilar artery ,contact aspiration ,intracranial angioplasty ,intracranial stenting ,ischemic stroke ,stent retriever ,Neurology. Diseases of the nervous system ,RC346-429 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background Two recent trials demonstrated a benefit for endovascular therapy (EVT) in the treatment of basilar artery occlusion (BAO). In light of the expected increase in the use of EVT for BAO, we sought to understand the technique preferences of neurointerventionalists performing EVT for BAO. Methods We conducted an international online survey of physician opinions on the use of EVT in BAO between January and March 2022. The survey was distributed through stroke and neurointerventional organizations. Survey questions examined selection of patients for the procedure and the techniques currently used for EVT in BAO. Responses from neurointerventionalists were analyzed. Results More than 3000 participants were invited yielding 1245 respondents, of whom 543 were classified as neurointerventionalists across 52 countries and included in this analysis. Most neurointerventionalists would proceed to EVT for occlusions of the V4 segment, the basilar artery, or the posterior cerebral artery, without regard for prior intravenous thrombolysis. For BAO of embolic etiology, aspiration only thrombectomy was the preferred method of 50.3% of neurointerventionalists. For BAO of intracranial atherosclerotic disease etiology, combined stent retriever and aspiration thrombectomy was the preferred method of 40.5% of neurointerventionalists. The majority of neurointerventionalists (88.0%) would proceed to stenting after 3 or fewer failed passes for patients with BAO of intracranial atherosclerotic disease etiology. In patients undergoing stenting, aspirin and clopidogrel was the most common antiplatelet regime (52.4%). Conclusions Among the surveyed neurointerventionalists, the most common techniques for EVT of patients with BAO were contact aspiration or combined stent retriever with aspiration thrombectomy. For patients with BAO due to intracranial atherosclerotic disease, the majority of neurointerventionalists were willing to stent and do so most often after 3 or fewer failed passes and with the use of dual antiplatelet medications. Further study is needed to determine the optimal technique for EVT of BAO with or without intracranial atherosclerotic disease. Key Words
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- 2023
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25. Late Window Imaging Selection for Endovascular Therapy of Large Vessel Occlusion Stroke: An International Survey
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Thanh N. Nguyen, Piers Klein, Anne Berberich, Simon Nagel, Mohamad Abdalkader, Ana Herning, Yimin Chen, Xiaochuan Huo, Zhongrong Miao, Sunil A. Sheth, Muhammad M. Qureshi, James E. Siegler, Simona Sacco, Daniel Strbian, Urs Fischer, Hiroshi Yamagami, Espen Saxhaug Kristoffersen, Volker Puetz, Wouter Schonewille, Georgios Tsivgoulis, Brian Drumm, Soma Banerjee, Jelle Demeestere, Fana Alemseged, Else C. Sandset, Anita Ante Arsovska, Kailash Krishnan, Permesh S. Dhillon, Angel Corredor, Rodrigo Rivera, Petra Sedova, Robert Mikulik, Hesham E. Masoud, Sheila O. Martins, Thang Huy Nguyen, Mai Duy Ton, Xinfeng Liu, Yuyou Zhu, Fengli Li, Wan Asyraf Wan Zaidi, Marialuisa Zedde, Shadi Yaghi, Jian Miao, Violiza Inoa, Liqun Zhang, Rytis Masiliūnas, Peter Slade, Sarah Shali Matuja, João Pedro Marto, Patrik Michel, Jens Fiehler, Götz Thomalla, Alicia C. Castonguay, Maxim Mokin, Mark Parsons, Bruce C.V. Campbell, Dileep R. Yavagal, Diederik Dippel, Mayank Goyal, Osama O. Zaidat, Tudor G. Jovin, Wei Hu, Raul G. Nogueira, Zhongming Qiu, Jean Raymond, and Gustavo Saposnik
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endovascular therapy ,large vessel occlusion ,late window ,mechanical thrombectomy ,Neurology. Diseases of the nervous system ,RC346-429 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background Current stroke guidelines recommend advanced imaging (computed tomography [CT] perfusion or magnetic resonance imaging) prior to endovascular therapy (EVT) in patients with late presentation of large vessel occlusion. Adherence to guidelines may be constrained by resources or timely access to imaging. We sought to understand the factors which influence late window imaging selection for EVT candidates with large vessel occlusion. Methods We conducted an international survey from January to May 2022. The questions aimed to identify advanced imaging and treatment decisions based on access to imaging, time delays, and simulated patient scenarios. Results There were 3000 invited participants and 1506 respondents, the majority (89.6%) from comprehensive stroke centers in high‐income countries. Neurointerventionalists comprised 31.8% and noninterventionalists 68.2% of respondents. Overall, 70.7% reported routine use of advanced imaging for late EVT selection, and 63.6% reported its usage in every case. There was greater availability of advanced imaging in comprehensive stroke centers versus primary stroke centers (67.0% versus 33.7%; P
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- 2023
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26. Structural, vibrational and photoluminescence properties of samarium doped cobalt tungstates
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Derraji, Kaouther, Lucena, Luciana, Favotto, Claude, Valmalette, Jean-Christophe, Villain, Sylvie, Nolibe, Gilles, Lyoussi, Abdallah, Guinneton, Frederic, and Gavarri, Jean-Raymond
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- 2022
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27. Formal Proof of the Weak Goodstein Theorem
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Abrial, Jean-Raymond
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Computer Science - Software Engineering ,D.2.4 - Abstract
For many years, I have been interested in introducing students to the development of complex systems by means of modelling and refinement. To this end, I did not find anything better than presenting many examples of system developments. However, I figured out that my examples were not explicit enough on how (mechanical) proofs are performed. So, besides courses presenting these examples and also some courses in various forms of proofs (propositional calculus, first order predicate calculus, set theory), I decided to study the work of professional mathematicians, thinking that it could be good examples for students. Among the works I already studied and reconstructed are the theorem of Zermelo, the theorem of Cantor-Bernstein, the planar graph theorem of Kuratowski, the topological proof of the infinity of primes of Furstenberg, the intermediate value theorem of Bolzano, the Archimedean property of the set of Real numbers, and others. More recently, I found that the Goodstein theorem was also very interesting. The purpose of this short note is to give some information about this theorem and the way I introduce a weak form of it to students., Comment: Event-B day 2016, Tokyo
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- 2016
28. Biochemical and hematological factors associated with COVID-19 severity among Gabonese patients: A retrospective cohort study
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Nadine N’dilimabaka, Dieudonné Mounguegui Mounguegui, Sonia Etenna Lekana-Douki, Marisca Kandet Yattara, Judicaël Obame-Nkoghe, Neil Michel Longo-Pendy, Ingrid Precilya Koumba Koumba, Octavie Lauris Banga Mve-Ella, Schedy Koumba Moukouama, Cresh Emelya Dzembo, Lauriane Yacka Bolo, Prudence Biyie-Bi-Ngoghe, Guignali Laurette Mangouka, Jean-Raymond Nzenze, and Jean-Bernard Lekana-Douki
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Gabonese COVID-19 patients ,asymptomatic ,mild/moderate ,severe/critic ,biochemical and hematological markers ,disease severity factors ,Microbiology ,QR1-502 - Abstract
The COVID-19 disease presents a large range of clinical manifestations and includes asymptomatic, mild, and severe cases. The level of severity is related to parameters associated with immunity, genetics, and biochemistry. Africa shows one of the lowest COVID-19 fatality rates but very few data on the biochemical markers of COVID-19 in patients and the factors associated with disease severity are available for the continent. In Gabon, the COVID-19 fatality rate is only 0.63% but almost no data on biomarkers in COVID-19 patients have been published. Both the number of COVID-19 cases and the mortality rate reported in Africa in general, and in Gabon in particular, are lower than in non-African countries. As such, understanding the factors associated with disease severity in Gabonese patients is a crucial step to better understand the disease in the African context and prepare for future COVID-19 waves and other epidemics of emerging diseases. Here, we compared biochemical and hematological markers among 753 Gabonese COVID-19 patients with asymptomatic (184/753), mild/moderate (420/753), and severe/critical (149/753) forms of the disease using an Analysis of Variance (ANOVA) or a Kruskal-Wallis (KW) test. We modeled these parameters together with comorbidities, age, and sex to predict factors associated with disease severity by using a "binomial generalized linear model" utilizing the "package" stats of R software version 4.0.2. Our results showed that almost all the biochemical and hematological parameters (except creatinine, phosphorus, D-dimers, platelets, and monocytes) varied according to disease severity. However, age and the dysfunction of organs like the kidney, liver, and lung together with the decrease of electrolytes (chloride, potassium, and sodium) are the best predictors of disease severity in Gabonese patients.
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- 2022
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29. Fractional Flow Reserve to Guide Treatment of Patients With Multivessel Coronary Artery Disease
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Leborgne, Laurent, Fournier, Alexandre, Jarry, Geneviève, Leleu, François, Malaquin, Dorothée, Mirode, Anfani, Belle, Loïc, Mangin, Lionel, Noirclerc, Nathalie, Barnay, Pierre, Hirsch, Jean-Lou, Metge, Marc, Pansiery, Michel, Soto, FrançoisXavier, Boge, Antoine, HadjHamou, Kamel, Miliani, Ichem, Molins, Guillaume, Mourot, Stéphane, Pelletier, Marion, Ressencourt, Olivier, Schaad, Frédéric, Coste, Pierre, Chasseriaud, Warren, Cetran, Laura, Poustis, Pierre, Morelle, Jean-Francois, Albert, Franck, Demicheli, Thibaud, Range, Grégroire, Thuaire, Christophe, Motreff, Pascal, Barber-Chamoux, Nicolas, Combaret, Nicolas, Malclès, Guilhem, Souteyrand, Géraud, Cottin, Yves, Buffet, Philippe, Gudjonvick, Aurélie, L’Huillier, Isabelle, Lorgis, Luc, Richard, Carole, Bertrand, Bernard, Baronne-Rochette, Gilles, Bouvaist, Hélène, Marlière, Stéphanie, Ormezzano, Olivier, Vanzetto, Gérald, Meunier, Ludovic, Trouillet, Charlotte, Valy, Yann, Lesault, Pierre-François, VanBelle, Eric, Bauters, Christophe, Delhaye, Cédric, Lemesle, Gilles, Rihani, Riadh, Graux, Pierre, Lemahieu, Jean-Michel, Harbaoui, Brahim, Besnard, Cyril, Courand, Pierre-Yves, Dauphin, Raphaël, Lantelme, Pierre, Perret, Thibault, Caignault, Jean-Raymond, Dubreuil, Olivier, Ranc, Sylvain, Ritz, Bernard, Rioufol, Gilles, Bergerot, Cyrille, Bochaton, Thomas, Bonnefoy-Cudraz, Eric, Bresson, Didier, Dementhon, Julie, Derimay, François, Finet, Gérard, Green, Lisa, Prieur, Cyril, Sanchez, Ingrid, Zouaghi, Oualid, Arméro, Sébastien, Lefèvre, Thierry, Ben-Amer, Hakim, Chevalier, Bernard, Garot, Philippe, Hovasse, Thomas, Louvard, Yves, Morice, Marie-Claude, Tavolaro, Oscar, Unterseeh, Thierry, Dupouy, Patrick, Roubille, François, Cung, DinhThienTri, Macia, Jean-Christophe, Piot, Christophe, Levy, Gilles, Roth, Olivier, Jacquemin, Laurent, Wiedemann, Jean-Yves, Cayla, Guillaume, Cornillet, Luc, Ledermann, Bertrand, Schmutz, Laurent, Lafont, Antoine, Karam, Nicole, Rahal, Saliha, Caussin, Christophe, Amabile, Nicolas, Girard, Philippe, Veugeois, Aurélie, Barthélémy, Olivier, Collet, Jean-Philippe, Montalescot, Gilles, Koning, René, Berland, Jacques, Godin, Matthieu, Landolff, Quentin, Zoghlami, Bilel, Pouillot, Christophe, Bougrini, Karim, Geyer, Christophe, Glanenapp, Jens, Mascarel, Patrick, Rambaud, Geoffray, ViFane, Richard, Angoulvant, Denis, Desveaux, Bernard, Ivanes, Fabrice, Pacouret, Gérard, Quilliet, Laurent-Emmanuel, SaintEtienne, Christophe, Chapon, Philippe, Bretelle, Christophe, Champin, Stanislas, Dérimay, François, Van Belle, Éric, Morelle, Jean-François, Soto, François-Xavier, Barthelemy, Olivier, Armero, Sébastien, Amaz, Camille, Vaz, Bernadette, Benyahya, Lakhdar, Varillon, Yvonne, Ovize, Michel, and Mewton, Nathan
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- 2021
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30. Predictive analysis of the value of information flow on the shop floor of developing countries using artificial neural network based deep learning
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Mbakop, André Marie, Biyeme, Florent, Voufo, Joseph, and Meva'a, Jean Raymond Lucien
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- 2021
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31. Reinforcement Learning for Adaptive Illumination with X-rays.
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Jean-Raymond Betterton, Daniel Ratner, Samuel Webb, and Mykel J. Kochenderfer
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- 2020
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32. A Stokes drift approximation based on the Phillips spectrum
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Breivik, Øyvind, Bidlot, Jean-Raymond, and Janssen, Peter A. E. M.
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Physics - Atmospheric and Oceanic Physics - Abstract
A new approximation to the Stokes drift velocity profile based on the exact solution for the Phillips spectrum is explored. The profile is compared with the monochromatic profile and the recently proposed exponential integral profile. ERA-Interim spectra and spectra from a wave buoy in the central North Sea are used to investigate the behaviour of the profile. It is found that the new profile has a much stronger gradient near the surface and lower normalized deviation from the profile computed from the spectra. Based on estimates from two open-ocean locations, an average value has been estimated for a key parameter of the profile. Given this parameter, the profile can be computed from the same two parameters as the monochromatic profile, namely the transport and the surface Stokes drift velocity., Comment: 27 pp, 7 figs, one table in Ocean Modelling, 2016
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- 2016
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33. Current Opinions on Optimal Management of Basilar Artery Occlusion: After the BEST of BASICS Survey
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Brian Drumm, Soma Banerjee, Muhammad M. Qureshi, Wouter J. Schonewille, Piers Klein, Xiaochuan Huo, Yimin Chen, Daniel Strbian, Urs Fischer, Volker Puetz, Wei Hu, Xunming Ji, Chuanhui Li, Fana Alemseged, Hiroshi Yamagami, Simona Sacco, Gustavo Saposnik, Patrik Michel, Espen Saxhaug Kristoffersen, Petra Sedova, Robert Mikulik, James E. Siegler, Thomas R. Meinel, Diana Aguiar de Sousa, Kyriakos Lobotesis, Dylan Roi, Jelle Demeestere, Kaiz S. Asif, Sheila O. Martins, Mohamad Abdalkader, Mayank Goyal, Thang Huy Nguyen, Mai Duy Ton, Yuyou Zhu, Xinfeng Liu, Zhongming Qiu, Zhongrong Miao, Jildaz Caroff, Michele Romoli, Francesco Diana, Götz Thomalla, Simon Nagel, Else C. Sandset, Bruce C.V. Campbell, Tudor G. Jovin, Raul G. Nogueira, Jean Raymond, and Thanh N. Nguyen
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basilar artery occlusion ,endovascular therapy ,intravenous thrombolysis ,mechanical thrombectomy ,Neurology. Diseases of the nervous system ,RC346-429 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background The best management of basilar artery occlusion (BAO) remains uncertain. The BASICS (Basilar Artery International Cooperation Study) and the BEST (Basilar Artery Occlusion Endovascular Intervention Versus Standard Medical Treatment) trials reported neutral results. We sought to understand physicians’ approaches to BAOs and whether further BAO randomized controlled trials were warranted. Methods We conducted an online international survey from January to March 2022 to stroke neurologists and neurointerventionalists. Survey questions were designed to examine clinical and imaging parameters under which clinicians would offer (or rescind) a patient with BAO to endovascular therapy (EVT) or best medical management versus enrollment into a randomized clinical trial. Results Of >3002 invited participants, 1245 responded (41.4% response rate) from 73 countries, including 54.7% stroke neurologists and 43.6% neurointerventionalists. More than 95% of respondents would offer EVT to patients with BAO, albeit in various clinical circumstances. There were 70.0% of respondents who indicated that the BASICS and BEST trials did not change their practice. Only 22.1% of respondents would perform EVT according to anterior circulation occlusion criteria. The selection of patients for BAO EVT by clinical severity, timing, and imaging modality differed according to geography, specialty, and country income level. Over 80% of respondents agreed that further randomized clinical trials for BAO were warranted. Moreover, 45.6% of respondents indicated they would find it acceptable to enroll all trial‐eligible patients into the medical arm of a BAO trial, whereas 26.3% would not enroll. Conclusion Most stroke physicians continue to believe in the efficacy of EVT in selected patients with BAO in spite of BEST and BASICS. There is no consensus on which selection criteria to use, and few clinicians would use anterior circulation occlusion criteria for BAOs. Further randomized clinical trials for BAO are warranted.
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- 2022
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34. Driving Safety Among Surgical Residents in the Era of Duty Hour Restrictions
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Freedman-Weiss, Mollie R., Heller, Danielle R., White, Erin M., Chiu, Alexander S., Jean, Raymond A., and Yoo, Peter S.
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- 2021
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35. « Une toile d’araignée dense et folle »
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Fanlo, Jean-Raymond, primary
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- 2021
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36. Eulerian modelling of the powder discharge of a silo: Attempting to shed some light on the origin of jet expansion
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Audard, François, Fede, Pascal, Belut, Emmanuel, Fontaine, Jean-Raymond, Neau, Hervé, and Simonin, Olivier
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- 2021
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37. A coupled thermo-mechanical damage model for fired clay bricks based on the unified strength theory
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Mpoung, Léon Arnaud, Bidoung, Jean Calvin, Sontia Metekong, Jean Valdez, and Meva’a, Jean Raymond Lucien
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- 2021
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38. Global Synthesis of Air-Sea CO2 Transfer Velocity Estimates From Ship-Based Eddy Covariance Measurements
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Mingxi Yang, Thomas G. Bell, Jean-Raymond Bidlot, Byron W. Blomquist, Brian J. Butterworth, Yuanxu Dong, Christopher W. Fairall, Sebastian Landwehr, Christa A. Marandino, Scott D. Miller, Eric S. Saltzman, and Alexander Zavarsky
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air-sea exchange ,gas exchange ,eddy covariance (EC) ,CO2 ,transfer velocity ,waves ,Science ,General. Including nature conservation, geographical distribution ,QH1-199.5 - Abstract
The air-sea gas transfer velocity (K660) is typically assessed as a function of the 10-m neutral wind speed (U10n), but there remains substantial uncertainty in this relationship. Here K660 of CO2 derived with the eddy covariance (EC) technique from eight datasets (11 research cruises) are reevaluated with consistent consideration of solubility and Schmidt number and inclusion of the ocean cool skin effect. K660 shows an approximately linear dependence with the friction velocity (u*) in moderate winds, with an overall relative standard deviation (relative standard error) of about 20% (7%). The largest relative uncertainty in K660 occurs at low wind speeds, while the largest absolute uncertainty in K660 occurs at high wind speeds. There is an apparent regional variation in the steepness of the K660-u* relationships: North Atlantic ≥ Southern Ocean > other regions (Arctic, Tropics). Accounting for sea state helps to collapse some of this regional variability in K660 using the wave Reynolds number in very large seas and the mean squared slope of the waves in small to moderate seas. The grand average of EC-derived K660(−1.47 + 76.67u*+ 20.48u*2 or 0.36 + 1.203U10n+ 0.167U10n2) is similar at moderate to high winds to widely used dual tracer-based K660 parametrization, but consistently exceeds the dual tracer estimate in low winds, possibly in part due to the chemical enhancement in air-sea CO2 exchange. Combining the grand average of EC-derived K660 with the global distribution of wind speed yields a global average transfer velocity that is comparable with the global radiocarbon (14C) disequilibrium, but is ~20% higher than what is implied by dual tracer parametrizations. This analysis suggests that CO2 fluxes computed using a U10n2 dependence with zero intercept (e.g., dual tracer) are likely underestimated at relatively low wind speeds.
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- 2022
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39. Surface Wave Effects in the NEMO Ocean Model: Forced and Coupled Experiments
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Breivik, Øyvind, Mogensen, Kristian, Bidlot, Jean-Raymond, Balmaseda, Magdalena Alonso, and Janssen, Peter A. E. M.
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Physics - Atmospheric and Oceanic Physics - Abstract
The NEMO general circulation ocean model is extended to incorporate three physical processes related to ocean surface waves, namely the surface stress (modified by growth and dissipation of the oceanic wave field), the turbulent kinetic energy flux from breaking waves, and the Stokes-Coriolis force. Experiments are done with NEMO in ocean-only (forced) mode and coupled to the ECMWF atmospheric and wave models. Ocean-only integrations are forced with fields from the ERA-Interim reanalysis. All three effects are noticeable in the extra-tropics, but the sea-state dependent turbulent kinetic energy flux yields by far the largest difference. This is partly because the control run has too vigorous deep mixing due to an empirical mixing term in NEMO. We investigate the relation between this ad hoc mixing and Langmuir turbulence and find that it is much more effective than the Langmuir parameterization used in NEMO. The biases in sea surface temperature as well as subsurface temperature are reduced, and the total ocean heat content exhibits a trend closer to that observed in a recent ocean reanalysis (ORAS4) when wave effects are included. Seasonal integrations of the coupled atmosphere-wave-ocean model consisting of NEMO, the wave model ECWAM and the atmospheric model of ECMWF similarly show that the sea surface temperature biases are greatly reduced when the mixing is controlled by the sea state and properly weighted by the thickness of the uppermost level of the ocean model. These wave-related physical processes were recently implemented in the operational coupled ensemble forecast system of ECMWF., Comment: 29 pp, 10 figures, 2 tables in J Geophys Res, 2015
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- 2015
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40. Waving in the rain
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Cavaleri, Luigi, Bertotti, Luciana, and Bidlot, Jean-Raymond
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Physics - Atmospheric and Oceanic Physics ,86A10 - Abstract
We consider the effect of rain on wind wave generation and dissipation. Rain falling on a wavy surface may have a marked tendency to dampen the shorter waves in the tail of the spectrum, the related range increasing with the rain rate. Following the coupling between meteorological and wave models, we derive that on the whole this should imply stronger wind and higher waves in the most energetic part of the spectrum. This is supported by numerical experiments. However, a verification based on the comparison between operational model results and measured data suggests that the opposite is true. This leads to a keen analysis of the overall process, in particular on the role of the tail of the spectrum in modulating the wind input and the white-capping. We suggest that the relationship between white-capping and generation by wind is deeper and more implicative than presently generally assumed., Comment: 20 pages, 9 figures, submitted to Journal of Geophysical Research
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- 2015
41. Ethical care requires pragmatic care research to guide medical practice under uncertainty
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Tim E. Darsaut and Jean Raymond
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Research ethics ,Clinical trials ,Equipoise ,Therapeutic obligation ,Medical care ,Evidence based medicine ,Medicine (General) ,R5-920 - Abstract
Abstract Background The current research-care separation was introduced to protect patients from explanatory studies designed to gain knowledge for future patients. Care trials are all-inclusive pragmatic trials integrated into medical practice, with no extra tests, risks, or cost, and have been designed to guide practice under uncertainty in the best medical interest of the patient. Proposed revision Patients need a distinction between validated care, previously verified to provide better outcomes, and promising but unvalidated care, which may include unnecessary or even harmful interventions. While validated care can be practiced normally, unvalidated care should only be offered within declared pragmatic care research, designed to protect patients from harm. The validated/unvalidated care distinction is normative, necessary to the ethics of medical practice. Care trials, which mark the distinction and allow the tentative use of promising interventions necessarily involve patients, and thus the design and conduct of pragmatic care research must respect the overarching rule of care ethics “to always act in the best medical interest of the patient.” Yet, unvalidated interventions offered in contexts of medical uncertainty cannot be prescribed or practiced as if they were validated care. The medical interests of current patients are best protected when unvalidated practices are restricted to a care trial protocol, with 1:1 random allocation (or “hemi-prescription”) versus previously validated care, to optimize potential benefits and minimize risks for each patient. Conclusion Pragmatic trials can regulate medical practice by providing (i) a transparent demarcation between unvalidated and validated care; (ii) norms of medical conduct when using tests and interventions of yet unknown benefits in practice; and eventually (iii) a verdict regarding optimal care.
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- 2021
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42. Impact of wave-dependent stress on storm surge simulations in the North Sea: Ocean model evaluation against in situ and satellite observations
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Pineau-Guillou, Lucia, Bouin, Marie-Noëlle, Ardhuin, Fabrice, Lyard, Florent, Bidlot, Jean-Raymond, and Chapron, Bertrand
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- 2020
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43. The ABZ-2018 case study with Event-B.
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Jean-Raymond Abrial
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- 2020
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44. Practicing outcome-based medical care using pragmatic care trials
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Tim E. Darsaut and Jean Raymond
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Randomized trials ,Pragmatic trials ,Clinical research methodology ,Medical ethics ,Research ethics ,Medicine (General) ,R5-920 - Abstract
Abstract The current separation between medical research and care is an obstacle to essential aspects of good medical practice: the verification that care interventions actually deliver the good outcomes they promise, and the use of scientific methods to optimize care under uncertainty. Pragmatic care trials have been designed to address these problems. Care trials are all-inclusive randomized trials integrated into care. Every item of trial design is selected in the best medical interest of participating patients. Care trials can eventually show what constitutes good medical practice based on patient outcomes. In the meantime, care trials give clinicians and patients the scientific methods necessary for optimization of medical care when no one really knows what to do. We report the progress of 9 randomized care trials that were used to guide the endovascular or surgical management of 1212 patients with acute stroke, intracranial aneurysms, and arteriovenous malformations in a single center in an elective or acute care context. Care trials were used to address long-standing dilemmas regarding rival medical, surgical, or endovascular management options or to offer innovative instead of standard treatments. The trial methodology, by replacing unrepeatable treatment decisions by 1:1 randomized allocation whenever reliable knowledge was not available, had an immediate impact, transforming unverifiable dogmatic medical practice into verifiable outcome-based medical care. We believe the approach is applicable to all medical or surgical domains, but widespread adoption may require the revision of many currently prevalent views regarding the role of research in clinical practice.
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- 2020
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45. Lignes de vie: Un itinéraire personnel, une démarche de transmission
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Jean-Raymond Loisel and Jean-Raymond Loisel
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- 2021
46. National trends in palliative care use among older adults with cardiopulmonary and malignant conditions
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Feder, Shelli L., Jean, Raymond A., Bastian, Lori, and Akgün, Kathleen M.
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- 2020
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47. Comprehensive Analysis of the Effect of Ketorolac Administration after Pancreaticoduodenectomy
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Kunstman, John W., Brandt, Whitney S., Azar, Sara Abou, Jean, Raymond A., and Salem, Ronald R.
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- 2020
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48. ASSOCIATION OF TEACHING STATUS READMISSIONS AMONG CRITICALLY ILL PATIENTS WITH ACUTE RESPIRATORY FAILURE AND SEPSIS
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LEYS, LORENZO, primary, SHARMA, VENUS, additional, CHANDER, SUBHASH, additional, BRIMAH, IDAYAT, additional, JEAN, RAYMOND A, additional, and JEAN, RAYMONDE, additional
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- 2023
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49. THE ASSOCIATION OF TEACHING STATUS ON INPATIENT MORTALITY AMONG CRITICALLY ILL PATIENTS WITH SEPSIS
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LEYS, LORENZO, primary, SALMAN, SIDRA, additional, LUBY, SARA, additional, RADHAKRISHNAN NAIR, DEEPANJALI, additional, JEAN, RAYMOND A, additional, and JEAN, RAYMONDE, additional
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- 2023
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50. Wind and Wave Extremes over the World Oceans from Very Large Ensembles
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Breivik, Øyvind, Aarnes, Ole Johan, Abdalla, Saleh, Bidlot, Jean-Raymond, and Janssen, Peter A. E. M.
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Physics - Atmospheric and Oceanic Physics - Abstract
Global return values of marine wind speed and significant wave height are estimated from very large aggregates of archived ensemble forecasts at +240-h lead time. Long lead time ensures that the forecasts represent independent draws from the model climate. Compared with ERA-Interim, a reanalysis, the ensemble yields higher return estimates for both wind speed and significant wave height. Confidence intervals are much tighter due to the large size of the dataset. The period (9 yrs) is short enough to be considered stationary even with climate change. Furthermore, the ensemble is large enough for non-parametric 100-yr return estimates to be made from order statistics. These direct return estimates compare well with extreme value estimates outside areas with tropical cyclones. Like any method employing modeled fields, it is sensitive to tail biases in the numerical model, but we find that the biases are moderate outside areas with tropical cyclones., Comment: 28 pages, 16 figures
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- 2014
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