Search

Your search keyword '"Jéquier, E."' showing total 628 results
Start Over Author "Jéquier, E."
628 results on '"Jéquier, E."'

17. Muscle glycogen recovery after exercise measured by13C-magnetic resonance spectroscopy in humans: effect of nutritional solutions

Author

Rotman, S., Slotboom, J., Kreis, R., Boesch, C., Jéquier, E., Rotman, S., Slotboom, J., Kreis, R., Boesch, C., and Jéquier, E.

Abstract

The rate of glycogen resynthesis in human skeletal muscle after glycogen-depleting exercise is known to depend on carbohydrate intake and is reported to reach a platean after an adequate amount of carbohydrate (CHO) consumption. Efforts to maximize the rate of glycogen storage by changing the type and form of CHO, as well as by adding proteins or lipids have yielded inconsistent results. The objective of this study was to assess whether isocaloric addition of proteins and arginine to a CHO diet in the first 4 h after an endurance exercise would increase the rate of glycogen synthesis. The CHO solution, given twice at a 2 h interval according to earlier optimized protocols, contained 1.7 g CHO kgbody weight. The effects of this solution were compared to those of an isocaloric solution containing 1.2 g CHO/kgbody weight plus 0.5 g protein/kgbody weight (including 5 g arginine). Glycogen was measured in quadriceps muscle in vivo with natural abundance13C-magnetic resonance spectroscopy before exercise and twice after exercise, before and at the end of a 4-h period following the intake of one of the solutions. Eight subjects took part in a randomized cross-over trial separated by at least 1 week. Glycogen synthesis was found to be significantly increased with both regimes compared to a zero-caloric placebo diet, but no significant difference in glycogen resynthesis was found between the CHO-only diet and the one supplemented by proteins and arginine. It is estimated that significance would have been reached for an increase of 34%, while the effectively measured synthesis rates only differed by 5%

Published
2018

18. Comparison of carbohydrate utilization in man using indirect calorimetry and mass spectrometry after an oral load of 100 g naturally-labelled [13C]glucose

Author

Ebiner, J. R., Acheson, K. J., Doerner, A., Maeder, E., Arnaud, M. J., Jéquier, E., and Felber, J. P.

Abstract

1. Carbohydrate (CHO) oxidation was measured simultaneously in a group of five normal subjects after an oral load of 100 g naturally-labelled [13C]glucose, using indirect calorimetry and mass spectrometry. 2. CHO utilization, calculated from the results of indirect calorimetry, increased 30 min after the glucose load to reach a peak at 90 min. It then decreased to reach basal values at 380 min. Cumulative total CHO oxidation at 480 min was 83±8g, and CHO oxidized above basal levels, 37±3 g. 3. Enrichment of expired carbon dioxide with 13C began at 60 min and maximum values were observed at 270 min. At 480 min, cumulative CHO oxidation measured by use of [13C]glucose was 29 g. The difference from calorimetric values can be attributed in part to the slow isotopic dilution in the glucose and bicarbonate pools. 4. Thus, approximately 30% of the glucose load was oxidized during the 8 h after its ingestion and this accounts for a significant part of the increased CHO oxidation (37 g), as measured by indirect calorimetry

Published
2017

19. Carbohydrate utilization in obese subjects after an oral load of 100 g naturally-labelled [13C] glucose

Author

Ravussin, E., Doerner, Annelise, Acheson, K. J., Pahud, P., Arnaud, M. J., and Jéquier, E.

Abstract

1. Total carbohydrate (CHO) and ingested glucose oxidation was measured in five obese subjects with normal glucose tolerance after an oral load of 100g naturally-labelled [13C]glucose using indirect calorimetry and mass spectrometry respectively. 2. CHO utilization rate (107 ± 14 mg/min in the post-absorptive state) increased 30 min after the glucose load to reach a plateau (245±25 mg/min) between 90 and 120 min. It then decreased to basal values at 330 min. Cumulative CHO oxidation over 480 min was 66±7 g and the CHO oxidized above basal levels was 26 ± 7g. 3. Enrichment of expired carbon dioxide with 13c began at 45 min and maximum values were observed between 210 and 300 min. At 480 min, cumulative oxidation of the ingested glucose was 24± 2 g. 4. Compared with controls, the obese subjects exhibit an impairment of CHO utilization which precedes glucose intolerance. This impairment can be explained by an increased availability of free fatty acids which favours lipid oxidation at the expense of ingested [13C]glucose oxidation

Published
2017

22. Thermic effect of glucose and amino acids in man studied by direct and indirect calorimetry

Author

Pittet, Ph, Gygax, P. H., Jéquier, E., Pittet, Ph, Gygax, P. H., and Jéquier, E.

Abstract

1. In order to reinvestigate the classical concept of specific dynamic action of food, the thermic effect of ingested glucose (50 g) or essential amino acids (50 g) or both was measured in seven healthy male subjects dressed in shorts, by using both direct and indirect calorimetry simultaneously. Experiments were performed under conditions of thermal comfort at 28°. 2. Energy ‘balance' (heat production minus heat losses) was negative during the control period (mean heat deficit: −16.0 ± 0.8 kJ/m2 per h. 3. Metabolic rate increased 13.6 ± 1.8% after the glucose load, 17.2 ± 1.4% after amino acids, and 17.3 ± 2.9% after both glucose and amino acids: thus there was no additive thermic effect when both nutrients were given together. 4. In contrast to the metabolic rate, heat losses were not significantly altered after nutrient ingestion; consequently, the energy ‘balance' became rapidly positive. 5. These results show that: (a) the food-induced thermogenesis, for a moderate energy intake, is less dependent on the nature of the nutrients than was classically admitted; (b) this increased heat production mainly induces changes in heat storage rather than in heat losses during the first hours following ingestion of a meal

Published
2017

23. Thermic effect of glucose in obese subjects studied by direct and indirect calorimetry

Author

Pittet, Ph, Chappuis, Ph, Acheson, K., De Techtermann, F., JÉquier, E., Pittet, Ph, Chappuis, Ph, Acheson, K., De Techtermann, F., and JÉquier, E.

Abstract

1. The thermic effect of a glucose load (50 g) was studied in ten control and eleven obese female subjects, using both direct and indirect calorimetry simultaneously. Experiments were done under conditions of thermal equilibrium (28° and 30% relative humidity).. 2. Thermal balance (heat production measured by indirect calorimetry minus heat losses measured directly) was negative in the control group during the fasting period (heat deficit - 14.2 ± 5.0 kJ/m2 per h), whereas that of the obese group was in equilibrium (+ 1.4 ± 4.8 kJ/m2 per h).. 3. After the glucose load, metabolic rate increased 13.0 ± 1.5 and 5.2 ± 1.3% in the control and obese groups respectively.. 4. In contrast to the metabolic rate, total heat losses were not significantly altered in either group after the glucose load. Total heat losses of the obese group were significantly lower than those of the control group throughout the experimental period.. 5. During the experiments the amount of heat stored was increased in both groups. Thermal balance in the control group became positive while that of the obese group remained positive.. 6. During the fasting period, the control subjects oxidized more carbohydrates (90.4 mg/min) than lipids (68.8 mg/min), whereas obese subjects oxidized more lipids (103.7 mg/min) than carbohydrates (50.2 mg/min). After the glucose load, the oxidation rate of carbohydrates was increased in both groups to 158.1 mg/min in control subjects and 95.6 mg/min in obese subjects.. 7. The mean skin temperature of the control subjects was significantly higher than that of the obese subjects and remained higher throughout the postprandial period.. 8. These results indicate that: (a) during the fasting period, the energy sources utilized and the thermal balance of the two groups were different; (b) the thermic effect of glucose was less in the obese subjects and, therefore, might be a factor contributing to their low energy expenditure

Published
2017

27. Tenth Annual Meeting of the European Association for the Study of Diabetes: Jerusalem, Israel, September 11–13, 1974

Author

Alberti, K. G. M. M., Iversen, J., Christensen, N. J., Andersson, A., Jarrousse, Claire, Andersson, Arne, Hellerström, Claes, Andreani, D., Tamburrano, G., Tamburrano, S., Gambardella, S., Ardill, Joy, Montgomery, D. A. D., Hadden, D. R., Assan, R., Attali, J. R., Selmi, A., Bourdillat, N., Soufflet, E., Girard, J. R., Bajaj, J. S., Chinna, G. S., Garg, S. K., Singh, Baldev, Balasse, E. O., Neef, M. A., Beischer, W., Melani, F., Keller, L., Hinz, M., Kroder, A., Maier, V., Pfeiffer, E. F., Bendayan, M., Sandborn, E., Rasio, E., Bensoussan, D., Levy-Toledano, S., Passa, P., Caen, J., Berger, M., Goodman, M. N., Hagg, S. A., Ruderman, N. B., Beyer, J., Cordes, U., Travniczek, H., Heider, W., Schöffling, K., Happ, J., Grimm, H., Pünchera, W., Althoff, P. H., Fröhlich, A., Bianco, A. R., Schwartz, R. H., Handwerger, B. S., Blackshear, P. J., Holloway, P. A. H., Williamson, D. H., Boquist, L., Hellman, Bo, Lernmark, Åke, Täljedabl, Inge-Bert, Bottermann, P., Schweigart, U., Zilker, Th., Hansen, W., Brachet, E., Rogister, C., Broer, Y., Freychet, P., Rosselin, G., Brunengraber, H., Vertongen, F., Boutry, M., Camu, F., Christacopoulos, P., Karamanos, B., Papadimitriou, P., Kardatos, Ch., Christensen, Niels Juel, Neubauer, Bent, Christophe, Jean, Winand, Jacques, Dehaye, Jean, Cuendet, G. S., Loten, E. G., Jeanrenaud, B., Davis, E., Yodaiken, Ralph E., Yanko, L., Herman, J. B., Garcia, S. Duran, Jarrousse, C., Ditzel, J., Daugaard, Niels Peters, Andersen, Haakon, Egeberg, J., Nerup, J., Andersen, O. O., Kromann, H., Bendixen, G., Poulsen, J. E., Eschwege, E., Falkmer, S., Emdin, S. O., Havu, N., Biuw, L. Winbladh, Sundby, F., Cutfield, J. F., Cutfield, S. M., Dodson, G. G., Peterson, J. D., Steiner, D. F., Fallucca, F., Menzinger, G., Iavicoli, M., Federspil, G., de Palo, C., Zago, E., Casara, D., Zaccaria, M., Scandellari, C., Felber, J. -P., Magnenat, G., Curchod, B., Pittet, Ph., Lytras, N., Müller-Hess, R., Geser, C. A., Jéquier, E., Flanagan, R. W. J., Buchanan, K. D., Murphy, R. F., Fölling, Ivar, Fromantin, M., Freyria, J., Bressac, F., Geisthövel, W., Niedergerke, U., Morgner, K. D., Willms, B., Mitzkat, H. J., Gey, K. F., Bühler, E., Sommer, P., Gey, K. F., Georgi, H., Sommer, P., Lengsfeld, H., Ghiea, D., Costiner, E., Simionescu, L., Oprescu, M., Grill, V., Cerasi, E., Gundersen, H. J. G., Gutman, A., Adler, J., Bar-Or, D., Gutzeit, A., Cerasi, E., Guy-Grand, B., Bigorie, B., Gylfe, Erik, Idahl, Lars-Åke, Hamosh, Margit, Hamosh, Paul, Hart, Adrian, Cohen, H., Thorp, J. M., Hedeskov, C. J., Capito, K., Forruby, B., Henquin, J. C., Lambert, A. B., Lambert, A. E., Henquin, J. C., Hepp, K. D., Renner, R., Häring, H. U., Mehnert, H., Kemmler, W., Löffler, G., Mehnert, H., Herchuelz, A., Mahy, M., Herrera, Emilip, Garcia-Rafanell, J., Morell, J., Heuclin, Ch., Attali, J. R., Girard, J. R., Assan, R., Hicks, B. H., Taylor, C. I., Vij, S. K., Pek, S., Knopf, R. F., Floyd, Jr., J. C., Fajans, S. S., Hockaday, T. D. R., Hockaday, J. M., Mann, J. I., Turner, R. C., Hockaday, T. D. R., Honour, A. J., Ikeda, Y., Saito, S., Matsuura, Y., Obayashi, N., Morimoto, Y., Sano, T., Abe, M., Jacouot, R., Felix, J. M., Legrele, C., Sutter-Dub, M. -Th., Sutter, B. Ch. J., Kammerer, L., Fehér, J., Lévai, J., Dénes, R., Stützel, M., Balázsi, I., Láng, I., Littmann, L., Karakash, C., Assimacopoulos, F., Katsilambros, N., Papadopoulos, G., Varonos, D., Daikos, G., Keen, H., Jarrett, R. J., Fuller, J. H., Kiesselbach, N. H. K., Puls, W., Keup, U., Kikkawa, Ryuichi, Duvillard, D., Ravazzola, M., Stauffacher, W., Köbberling, J., Kattermann, R., Kobberling, J., Creutzfeldt, W., Kohner, Eva M., Hamilton, A. M., Joplin, G. F., Blach, R. K., Fraser, T. R., Kolb, H. J., Weiss, L., Wieland, O. H., Korn, A., Waldhäusl, W., Bonelli, J., Magometsohnigg, D., Hitzenberger, G., Kramp, Robert C., Kremer, G. J., Atzpodien, W., Schnellbacher, B., Krug, B., Mialhe, P., Gross, R., Landgraf, R., Landgraf-Leurs, M., Klingenburg, M., Melamed, I., Hörl, R., Jun, István Láng, Littmann, László, Stützel, Mária, Balázsi, Imre, Langslow, Derek R., Buchanan, Keith D., Freeman, Barry M., Berezin, Meir, Mincu, I., Dumitrescu, C., Ionescu-Tirgoviste, C., Mihalache, N., Boboia, D., Stanescu, J., Ghise-Beer, E., Georgescu, St., Bruckner, I., Popa, I., Muggeo, M., Tiengo, A., Padovan, D., Molinari, M., Müller, Walter A., and Sharp, Geoffrey W. G.

Published
1974
Full Text
View/download PDF

34. Union Schweizerischer Gesellschaften für experimentelle Biologie Berichte der 2. Jahresversammlung: Fribourg, 23.–24. Mai 1970

Author

Akert, K., Kawana, E., Pfenninger, K., Moor, H., Sandri, C., Arczynska, W., Held, D. R., Haab, P., Boudry, J. F., Rioch-Ramel, F., Burri, P. H., Weibel, E. R., Cerretelli, P., di Prampero, P. E., Piiper, J., Chinet, A., Farber, J. P., Bloom, D. A., Farhi, L. E., Chmouliovsky, M., Churchill, P. C., Dolivo, M., Koelle, G. B., Geelhaar, A., Robert, M., Handwerker, H. O., Wettstein, A., Hösli, L., TebĒcis, A. K., Schönwetter, H. P., Andrès, P. F., Hösli, E., Jirounek, P., Straub, R. W., Kalix, P., Kelly, J. S., Dreifuss, J. J., Jéquier, E., Krayenbühl, H. P., Mehmel, H., Rutishauser, W., Meier, R. E., Dalderup, J., Cuénod, M., Perisic, M., Niemeyer, G., Forssmann, W. G., Oetliker, H., McGuigan, J. A. S., Parmeggiani, P. L., Franzini, C., Scheid, P., Roch-Ramel, F., Jotterand, N., Scherrer, M., Bitterli, J., Siegwart, B., Steiner, C. A., Tomori, Z., Trachtenberg, M. C., Kornblith, P., Häuptli, J., Braun, R., Zellweger, A., Bron, Th., Rous, S., Chmelar, M., Chmelarova, M., Favarger, P., Cueni, L., Schoenenberger, G. A., Allgöwer, M., Schonbach, J., Exton, J. H., Miller, Jr., T. B., Park, C. R., Fellay, G., Portmann, P., GonÇalves, J., Honegger, C. G., Schardt, M., Hecker, H., Marx, W., Shoyab, M., Murer, H., Schatzmann, H. J., Schenker, T. M., von Wartburg, J. P., Schindler, R., Schaer, J. C., Grieder, A., Stauffacher, W., Amherdt, M., Cameron, D., Burr, I., Balant, L., Orci, L., Stucki, J. W., Walter, P., Touabi, M., Jeanrenaud, B., Wacker, H., Lehky, P., Stein, E., Anabitarte, M., Winterhalter, K. H., Tuchschmid, P., Briehl, R. W., Brunori, M., Amiconi, G., Antonini, E., Wyman, J., Anner, Béatrice, Ferrero, J., Schorderet, M., Burkard, W. P., Lengsfeld, H., Gey, K. F., Haefely, W., Corthay, J., Benakis, A., Glasson, B., Haeusler, G., Somlyo, A. V., Somlyo, A. P., Heinrich, U., Langemann, H., Lichtensteiger, W., Iynedjian, P. B., Peters, G., Jalfre, M., Monachon, M. A., Lazáry, S., Stähelin, H., Minder, R., Bickel, M. H., Müller, A. H., Brunner, H., Pletscher, A., Da Prada, M., Berneis, K. H., Thomasset, M., Black, L. W., Ahmad-Zadeh, C., Dubochet, J., Ducommun, M., Kellenberger, E., Wacher, Ph., Tesi, D., Daldrup, J., Gautier, A., Schreyer, M., Cogliati, R., Gautschi, J. R., Goodman, H. M., Billeter, M. A., Hindley, J., Weissmann, C., Granboulan, P., Hess, M. W., Sordat, B., Cottier, H., Joel, D. D., Kellenberger-van der Kamp, C., Kolakofsky, D., Mechler, B., Mach, B., Mira-Moser, F., Schiller, P., Schwyzer, R., Scholl, A., Eppenberger, H. M., Séchaud, J., Staehelin, M., Wehrli, W., Yanagida, M., and Ahmad-Zadeh, G.

Published
1970
Full Text
View/download PDF

35. Seventh Annual Meeting of the European Association for the Study Of Diabetes Southampton, England, September 15–17, 1971 Abstacts, Part 1

Author

Aboulker, J. P., Valleron, A. J., Papoz, L., Rathery, M., Adams, P. W., Munday, M. J., Oakley, N. W., Wynn, V., Andreani, D., Fallucca, F., Stirati, G., Tamburrano, G., Cinotti, G. A., Andreev, D., Tarkolev, N., Ditzov, S., Pencev, I., Ancreev, D., Sirskov, L., Arnold, R., Creutzfeldt, C., Deuticke, U., Frerichs, H., Track, N. S., Creutzfeldt, W., Asmal, A. C., Butterfieid, W. J. H., Karamanos, B., Whichelow, M. J., Butterfield, W. J. H., Cox, B. D., Ashcroft, S. J. H., Bassett, J. M., Randle, P. J., Asplund, K., Hellerström, C., Brolin, S. E., Berne, C., Edwards, John C., Petersson, B., Taylor, K. W., Assan, R., Hanoune, J., Attali, J. B., Tchobroutsky, G., Gross, G., Assimacopoulos, F., Orci, L., Rouiller, Ch., Jeanrenaud, B., Cameron, D. P., Amherdt, M., Mira, F., Stauffacher, W., Heindel, J. J., Cushman, S. W., Austoni, M., Federspil, G., Casara, D., Sieolo, N., Scandellari, C., Mastrogiacomo, I., Aynsley-Green, A., Alberti, K. G. M. M., Bacanu, Gh., Stoichescu, L., Nistor, F., Turcanu, V., Anghelescu, L., Bacchus, R. A., Meade, L. G., London, D. R., Baiasse, E. O., Barta, L., Brooser, G., Molnár, Maria, Belfiore, F., Vecchio, L. Lo, Napoli, E., Beyer, J., Cordes, U., Sell, G., Krall, N., Schöffling, K., Biebuyck, J. F., de Haan, B. Bierens, Scherrer, J. R., Pometta, D., Björntorp, P., Sjöström, L., Blach, R. K., Cheng, Hung, Bloom, S. R., Bojanowicz, K., Boquist, L., Brachet, E., Bruni, B., Capra, E., Büber, V., Felber, J. P., Buchanan, K. D., Connon, J. J., Buckle, R. M., Campeami, S., Campeanu, L., Ionesou, M., Cerasi, E., Luft, R., Efendic, S., Chabot, V., Gomez, F., Chiumello, G., del Guercio, M. J., Carnelutti, M., Christensen, Niels Juel, Iversen, J., Christiansen, Aa. Hein, Rasmussen, S. Munkgaard, Vø1und, Aa., Vólund, Aa., Clausen, T., Czyzyk, A., Szadkowski, M., Rogala, H., Lawecki, J., Davies, W. H., Martin, L. B., Mills, J. G., Vardey, C. J., Deckert, T., Lauridsen, U. Birk, Linde, J., Madsen, S. Nistrup, De Leeuw, I., Middelheim, A. Z., de Mowbray, R. R., Turner, J. J., Garner, S. D., Bruck, E., Nye, L., Triggs, S., Devlin, J. G., Varma, M., Kuti, J., Dumitrescu, C., Bolea-Feldman, M., Eschwege, E., Warnet, J. M., Richard, J. L., Menzinger, G., Javicoli, M., Fankhauser, S., Michl, J., Piemonte, G., Sicolo, N., Frezzato, S., Reffo, G. C., Luyckx, A., Lefebvre, P., Zaccaria, M., De Palo, C., Fernandes-Cruz, Jr., A., Lopiz-Quijada, C., Fernandez-Cruz, Jr., A., Otero, M. Luque, Fiedler, H., Hahn, H. J., Ziegler, Brigitte, Ziegler, M., Jutzi, E., Michael, R., Fischer, U., Hommel, H., Bibergeil, H., Förster, O., Rippel, W., Rudas, B., Franckson, J. R. M., Vanroux, R., Leclercq, R., Brunengraber, H., Ooms, H., Freytag, G., Klöppel, G., Fussgänger, R. D., Goberna, R., Schröder, K. E., Laube, H., Pfeiffer, E. F., Gazzola, G. C., Franchi, R., Ronchi, P., Saibene, E., Guidotti, G. G., Geldermans, C., Terpstra, J., Krans, H. M. J., Geser, C. A., Rattenhuber, E., Girard, J., Bal, D., Gligore, V., Mosora, N., Fekete, T., Beraru, T., Pipilian, V. V., Olteanu, L., Serban, A., Calusera, I., Holan, T., Miclutia, M., Gnudi, A., Coscelli, C., Ballerio, G., Palmari, V., Alpi, O., Cavazzini, G., Jéquier, E., Goth, E., Fövenyi, J., Hegedüs, A., Greco, A. V., Ghirlanda, G., Fedeli, G., Fenici, R., Gambassi, G., Grüneklee, D., Hessing, J., Daweke, H., Herberg, L., Gries, F. A., Guder, W., Wieland, O., Guillon, J., Bodic, L., Charbonnel, B., Hadden, D. R., Montgomery, D. A. D., Mayne, Elizabeth, Weaver, J. A., George E, Hahn, J., Richter, O., Steinhilber, S., Kerp, L., Heaney, S. J., Varma, S. K., Whyte, W. G., Walker, R. S., Hepp, K. D., Hellman, B., Lernmark, A., Sehlin, J., Täljedal, I. -B., Hinz, M., Katsilambros, N., Rahman, Y. Abdel, Schatz, H., Maier, V., Schröder, B., Howells, D. P. M., Jackson, R. A., Perry, G., Rogers, J., Advani, U., Jafflol, C., Baldet, L., Vierne, Y., Mirouze, J., Jansen, F. K., Jarrett, R. J., Keen, H., Kaeding, A., Kaffarnik, H., Heink, U., Gassel, W. D., Zöfel, P., Mylarch, K., Keller, U., and Froesch, E. R.

Published
1971
Full Text
View/download PDF

37. Obesity:Preventing and managing the global epidemic

Author

Akram, D. S., Astrup, A. V., Atinmo, T., Boissin, J. L., Bray, George A, Carroll, K., Chitson, P., Chunming, C., Dietz, W. H., Hill, J. O., Jéquier, E., Komodiki, C., Matsuzawa, Y., Mollentze, W. F., Moosa, K., Noor, M.I., Reddy, K.S., Seidell, J., Tanphaichitr, V., Uauy, R, and Zimmet, P.Z.

Subjects
SDG 3 - Good Health and Well-being
Published
2000

40. Interaction of lipid and carbohydrate metabolism after infusions of lipids or of lipid lowering agents: lack of a direct relationship between free fatty acid concentrations and glucose disposal

Author

Kleiber H, Munger R, Jallut D, Luc Tappy, Felley C, Golay A, Frascarolo P, Jéquier E, and Jp, Felber

Subjects
Adult, Blood Glucose, Male, Nicotinyl Alcohol, Calorimetry, Indirect, Fatty Acids, Nonesterified, Lipid Metabolism, Lipids, Carbohydrate Metabolism, Humans, Insulin, Infusions, Intravenous, Oxidation-Reduction, Glycogen, Hypolipidemic Agents
Abstract

The present work was planned to study the effects of changes in lipid metabolism irrespective of FFA concentrations (FFA) on the regulation of oxidative and nonoxidative disposal of a glucose infusion during hyperinsulinaemia. Fifteen normal volunteers participated in the 3 protocols, in which 1) Intralipid 2) beta-pyridylcarbinol or 3) isotonic saline were infused during 2 hours. Thereafter, these infusions were discontinued and a two-hour euglycaemic hyperinsulinaemic clamp was performed. All three studies were carried out in combination with indirect calorimetry to measure glucose uptake, and oxidative and nonoxidative glucose disposal (corresponding essentially to glucose storage). Plasma FFA concentrations were 508 +/- 34, 601 +/- 43 and 546 +/- 45 mumol/l in the basal state during the Intralipid, beta-pyridylcarbinol and control protocols. It increased to 960 +/- 71 mumol/l after the Intralipid infusion, fell to 246 +/- 17 mumol/l after the beta-pyridylcarbinol infusion, vs 600 +/- 48 mumol/l in the control. At the end of the glucose-insulin clamp the values were low in the 3 protocols: 263 +/- 17, 233 +/- 19 and 204 +/- 14 mumol/l. Intralipid infusion prior to the clamp protocol induced a suppression of both insulin-mediated glucose uptake (4.91 +/- 0.46 (Intralipid) vs 6.83 +/- 0.63 mg.kg-1.min-1 (saline)) and storage (1.61 +/- 0.34 vs 2.99 +/- 0.53 mg.kg-1.min-1) while beta-pyridylcarbinol infusion induced an increased insulin-mediated glucose uptake (8.58 +/- 0.37 mg.kg-1.min-1) and in glucose storage (4.29 +/- 0.31 mg.kg-1.min-1) (p less than 0.5 vs Intralipid). These changes occurred even though FFA plasma concentrations were similar in the 3 experimental conditions.(ABSTRACT TRUNCATED AT 250 WORDS)

Published
1992

Catalog

Books, media, physical & digital resources
See catalog results