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9. The CHK1 inhibitor prexasertib in BRCA wild-type platinum-resistant recurrent high-grade serous ovarian carcinoma: a phase 2 trial

Author

Giudice, Elena, Huang, Tzu-Ting, Nair, Jayakumar R., Zurcher, Grant, McCoy, Ann, Nousome, Darryl, Radke, Marc R., Swisher, Elizabeth M., Lipkowitz, Stanley, Ibanez, Kristen, Donohue, Duncan, Malys, Tyler, Lee, Min-Jung, Redd, Bernadette, Levy, Elliot, Rastogi, Shraddha, Sato, Nahoko, Trepel, Jane B., and Lee, Jung-Min

Published
2024
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16. The CHK1 inhibitor prexasertib in BRCA wild-type platinum-resistant recurrent high-grade serous ovarian carcinoma: a phase 2 trial

Author

Elena Giudice, Tzu-Ting Huang, Jayakumar R. Nair, Grant Zurcher, Ann McCoy, Darryl Nousome, Marc R. Radke, Elizabeth M. Swisher, Stanley Lipkowitz, Kristen Ibanez, Duncan Donohue, Tyler Malys, Min-Jung Lee, Bernadette Redd, Elliot Levy, Shraddha Rastogi, Nahoko Sato, Jane B. Trepel, and Jung-Min Lee

Subjects
Science
Abstract

Abstract The multi-cohort phase 2 trial NCT02203513 was designed to evaluate the clinical activity of the CHK1 inhibitor (CHK1i) prexasertib in patients with breast or ovarian cancer. Here we report the activity of CHK1i in platinum-resistant high-grade serous ovarian carcinoma (HGSOC) with measurable and biopsiable disease (cohort 5), or without biopsiable disease (cohort 6). The primary endpoint was objective response rate (ORR). Secondary outcomes were safety and progression-free survival (PFS). 49 heavily pretreated patients were enrolled (24 in cohort 5, 25 in cohort 6). Among the 39 RECISTv1.1-evaluable patients, ORR was 33.3% in cohort 5 and 28.6% in cohort 6. Primary endpoint was not evaluable due to early stop of the trial. The median PFS was 4 months in cohort 5 and 6 months in cohort 6. Toxicity was manageable. Translational research was an exploratory endpoint. Potential biomarkers were investigated using pre-treatment fresh biopsies and serial blood samples. Transcriptomic analysis revealed high levels of DNA replication-related genes (POLA1, POLE, GINS3) associated with lack of clinical benefit [defined post-hoc as PFS

Published
2024
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19. Electrospun Fibrous Scaffolds for Cardiac Tissue Engineering

Author

Ashok, Nivethitha, Kaliannagounder, Vignesh Krishnamoorthi, Kim, Cheol Sang, Park, Chan Hee, Jayakumar, R., Abe, Akihiro, Editorial Board Member, Albertsson, Ann-Christine, Editorial Board Member, Coates, Geoffrey W., Editorial Board Member, Genzer, Jan, Editorial Board Member, Kobayashi, Shiro, Editorial Board Member, Lee, Kwang-Sup, Editorial Board Member, Leibler, Ludwik, Editorial Board Member, Long, Timothy E., Editorial Board Member, Möller, Martin, Editorial Board Member, Okay, Oguz, Editorial Board Member, Percec, Virgil, Editorial Board Member, Tang, Ben Zhong, Editorial Board Member, Terentjev, Eugene M., Editorial Board Member, Theato, Patrick, Editorial Board Member, Voit, Brigitte, Editorial Board Member, Wiesner, Ulrich, Editorial Board Member, Zhang, Xi, Editorial Board Member, and Jayakumar, R., editor

Published
2023
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20. Fabrication of Multiscale Polymeric Fibres for Biomedical Applications

Author

Ashok, Nivethitha, Sowmya, S., Jayakumar, R., Abe, Akihiro, Editorial Board Member, Albertsson, Ann-Christine, Editorial Board Member, Coates, Geoffrey W., Editorial Board Member, Genzer, Jan, Editorial Board Member, Kobayashi, Shiro, Editorial Board Member, Lee, Kwang-Sup, Editorial Board Member, Leibler, Ludwik, Editorial Board Member, Long, Timothy E., Editorial Board Member, Möller, Martin, Editorial Board Member, Okay, Oguz, Editorial Board Member, Percec, Virgil, Editorial Board Member, Tang, Ben Zhong, Editorial Board Member, Terentjev, Eugene M., Editorial Board Member, Theato, Patrick, Editorial Board Member, Voit, Brigitte, Editorial Board Member, Wiesner, Ulrich, Editorial Board Member, Zhang, Xi, Editorial Board Member, and Jayakumar, R., editor

Published
2023
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21. Polymer/Ceramic Nanocomposite Fibers in Bone Tissue Engineering

Author

Sowmya, S., Mathivanan, Nirmal, Chandramouli, Arthi, Jayakumar, R., Abe, Akihiro, Editorial Board Member, Albertsson, Ann-Christine, Editorial Board Member, Coates, Geoffrey W., Editorial Board Member, Genzer, Jan, Editorial Board Member, Kobayashi, Shiro, Editorial Board Member, Lee, Kwang-Sup, Editorial Board Member, Leibler, Ludwik, Editorial Board Member, Long, Timothy E., Editorial Board Member, Möller, Martin, Editorial Board Member, Okay, Oguz, Editorial Board Member, Percec, Virgil, Editorial Board Member, Tang, Ben Zhong, Editorial Board Member, Terentjev, Eugene M., Editorial Board Member, Theato, Patrick, Editorial Board Member, Voit, Brigitte, Editorial Board Member, Wiesner, Ulrich, Editorial Board Member, Zhang, Xi, Editorial Board Member, and Jayakumar, R., editor

Published
2023
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22. Surface Modified Polymeric Nanofibers in Tissue Engineering and Regenerative Medicine

Author

Ashok, Nivethitha, Sankar, Deepthi, Jayakumar, R., Abe, Akihiro, Editorial Board Member, Albertsson, Ann-Christine, Editorial Board Member, Coates, Geoffrey W., Editorial Board Member, Genzer, Jan, Editorial Board Member, Kobayashi, Shiro, Editorial Board Member, Lee, Kwang-Sup, Editorial Board Member, Leibler, Ludwik, Editorial Board Member, Long, Timothy E., Editorial Board Member, Möller, Martin, Editorial Board Member, Okay, Oguz, Editorial Board Member, Percec, Virgil, Editorial Board Member, Tang, Ben Zhong, Editorial Board Member, Terentjev, Eugene M., Editorial Board Member, Theato, Patrick, Editorial Board Member, Voit, Brigitte, Editorial Board Member, Wiesner, Ulrich, Editorial Board Member, Zhang, Xi, Editorial Board Member, and Jayakumar, R., editor

Published
2023
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28. Monitoring of Harmful Algal Bloom (HAB) of Noctiluca scintillans (Macartney) along the Gulf of Mannar, India using in-situ and satellite observations and its impact on wild and maricultured finfishes

Author

Rameshkumar. P, Thirumalaiselvan, P.S., Raman, Mini, Remya, L., Jayakumar, R., Sakthivel, M., Tamilmani, G., Sankar, M., Anikuttan, K.K., Menon, N. Nandini, Saravanan, Raju, Ravikumar, T.T., Narasimapallavan, Iyyapparaja, Krishnaveni, N., Muniasamy, V., Batcha, S.M., and Gopalakrishnan, A.

Published
2023
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39. Synthesis-Structure Relationship of Chitosan Based Hydrogels

Author

Ashok, Nivethitha, Pradeep, Aathira, Jayakumar, R., Abe, Akihiro, Editorial Board Member, Albertsson, Ann-Christine, Editorial Board Member, Coates, Geoffrey W., Editorial Board Member, Genzer, Jan, Editorial Board Member, Kobayashi, Shiro, Editorial Board Member, Lee, Kwang-Sup, Editorial Board Member, Leibler, Ludwik, Editorial Board Member, Long, Timothy E., Editorial Board Member, Möller, Martin, Editorial Board Member, Okay, Oguz, Editorial Board Member, Percec, Virgil, Editorial Board Member, Tang, Ben Zhong, Editorial Board Member, Terentjev, Eugene M., Editorial Board Member, Theato, Patrick, Editorial Board Member, Voit, Brigitte, Editorial Board Member, Wiesner, Ulrich, Editorial Board Member, Zhang, Xi, Editorial Board Member, Jayakumar, R., editor, and Prabaharan, M., editor

Published
2021
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40. Chitosan Based Biomaterials for Periodontal Therapy

Author

Rajendran, Arun Kumar, Jayakumar, R., Abe, Akihiro, Editorial Board Member, Albertsson, Ann-Christine, Editorial Board Member, Coates, Geoffrey W., Editorial Board Member, Genzer, Jan, Editorial Board Member, Kobayashi, Shiro, Editorial Board Member, Lee, Kwang-Sup, Editorial Board Member, Leibler, Ludwik, Editorial Board Member, Long, Timothy E., Editorial Board Member, Möller, Martin, Editorial Board Member, Okay, Oguz, Editorial Board Member, Percec, Virgil, Editorial Board Member, Tang, Ben Zhong, Editorial Board Member, Terentjev, Eugene M., Editorial Board Member, Theato, Patrick, Editorial Board Member, Voit, Brigitte, Editorial Board Member, Wiesner, Ulrich, Editorial Board Member, Zhang, Xi, Editorial Board Member, Jayakumar, R., editor, and Prabaharan, M., editor

Published
2021
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41. Different Forms of Chitosan and Its Derivatives as Hemostatic Agent and Tissue Sealants

Author

Sundaram, M. Nivedhitha, Pradeep, Aathira, Varma, Praveen Kerala, Jayakumar, R., Abe, Akihiro, Editorial Board Member, Albertsson, Ann-Christine, Editorial Board Member, Coates, Geoffrey W., Editorial Board Member, Genzer, Jan, Editorial Board Member, Kobayashi, Shiro, Editorial Board Member, Lee, Kwang-Sup, Editorial Board Member, Leibler, Ludwik, Editorial Board Member, Long, Timothy E., Editorial Board Member, Möller, Martin, Editorial Board Member, Okay, Oguz, Editorial Board Member, Percec, Virgil, Editorial Board Member, Tang, Ben Zhong, Editorial Board Member, Terentjev, Eugene M., Editorial Board Member, Theato, Patrick, Editorial Board Member, Voit, Brigitte, Editorial Board Member, Wiesner, Ulrich, Editorial Board Member, Zhang, Xi, Editorial Board Member, Jayakumar, R., editor, and Prabaharan, M., editor

Published
2021
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42. Application of Chitosan and Its Derivatives in Transdermal Drug Delivery

Author

Panonnummal, Rajitha, Kumar, Vrinda S., Jayakumar, R., Sabitha, M., Abe, Akihiro, Editorial Board Member, Albertsson, Ann-Christine, Editorial Board Member, Coates, Geoffrey W., Editorial Board Member, Genzer, Jan, Editorial Board Member, Kobayashi, Shiro, Editorial Board Member, Lee, Kwang-Sup, Editorial Board Member, Leibler, Ludwik, Editorial Board Member, Long, Timothy E., Editorial Board Member, Möller, Martin, Editorial Board Member, Okay, Oguz, Editorial Board Member, Percec, Virgil, Editorial Board Member, Tang, Ben Zhong, Editorial Board Member, Terentjev, Eugene M., Editorial Board Member, Theato, Patrick, Editorial Board Member, Voit, Brigitte, Editorial Board Member, Wiesner, Ulrich, Editorial Board Member, Zhang, Xi, Editorial Board Member, Jayakumar, R., editor, and Prabaharan, M., editor

Published
2021
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47. Molecular docking of phosphoprotein with antiviral drugs using SwissDock software for rabies viral treatment.

Author

Akshara, M. L., Jayakumar, R., and Thiruchelvam, V.

Subjects
*ANTIVIRAL agents, *BANKING industry, *VIRUS diseases, *RABIES virus, *VIRAL proteins
Abstract

The study's objective is to discover innovative antiviral medications that prevent phosphoprotein when SwissDock software is used to analyze viral infections with the greatest fatality rates, such as Rabies. The clincalc.com was used to calculate sample sizes G power was set at 80%. In this investigation, 10 various drugs (N=10) in total, along with a reference drug, were chosen to determine each drug's ability to bind to and inhibit the viral protein. A reference drug was used to compare results. Three-dimensional structures of ten antiviral drugs were found in the Protein Data Bank (PDB) chemical database, along with the three-dimensional structure of phosphoprotein. SwissDock was used to perform molecular docking of antiviral drugs with phosphoprotein. The software algorithm generates outputs by leveraging the similar shapes of biomolecules. SwissDock analysis indicates that 10 novel antiviral drugs bind with the phosphoprotein. Among these drugs, the novel antiviral drug Zanamivir exhibited a p-value of p=0.001 (p<0.05) in an independent sample t-test. This suggests that the full fitness data demonstrated a statistically significant difference between Zanamivir and the reference drug. It was found that the tested medicine Zanamivir interacted more strongly with the viral phosphoprotein; as a result, it was determined that this medication may effectively reduce the phosphoprotein and be used to treat rabies virus infections. [ABSTRACT FROM AUTHOR]

Published
2024
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