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Background: Spina bifida is one of the neural tube defects substantially related to significant morbidity and mortality worldwide. A complex of environmental and genetic factors has been a risk factor for spina bifida. This study aims to assess the prevalence of spina bifida and related risk factors in Taif city, Saudi Arabia. Methods: A retrospective chart review was done at Taif Hospitals, Saudi Arabia. The study was conducted by reviewing medical files of all infants and children born with spina bifida between January 1, 2018 and December 31, 2020. All files fulfilling the inclusion criteria were reviewed for data extraction using pre-structured data extraction sheet. Results: A total of 15 infants and children with spina bifida among 43,890 live births in Taif city were identified with an incidence of 3.5 per 100,000 children. Among the 15 studied subjects, 9 were females, and the other 6 children were males. The exact of nine (60%) children with spina bifida had Myelomeningocele. Mothers ages at child delivery were 30 years or more was among 60% of the cases mothers. Two-thirds of cases mothers had no folic acid supplements during pregnancy. Conclusion: In conclusion, the current study revealed that spina bifida was around the global reported incidence, which was more common with more serious complications among females. Lack of folic acid supplementation at the periconceptional period was found to be the most reported risk factor.

Aim This study aimed to assess the relationship between loneliness and hypothyroidism in patients with hypothyroidism and to determine predictors of loneliness. Materials and methods A cross-sectional study was conducted on hypothyroid patients attending the endocrine clinics at Alhada Military Hospital and Prince Mansour Military Hospital, Taif, Saudi Arabia between the period of December 2020 and May 2021. Patients with more than 18 years of hypothyroidism were included and those with other thyroid diseases were excluded as well as those with other comorbidities and psychiatric disorders and those who were living alone. Data were collected using an online pre-structured questionnaire. Results The study included 231 hypothyroid patients with a mean age of 43.34 ± 12.9 years, and 90.9% were females. The majority (96.5%) were taking levothyroxine, and 27.3% were practicing physical activity. Only 2.2% of the participants had a high degree of loneliness, whereas 47.2%, 34.6%, and 16% had low, moderate, and moderately high degrees of loneliness, respectively. Discussion In this study, 2.2% of sampled hypothyroid patients had high (2.2%) or moderately high degrees of loneliness feelings (16%). Duration of hypothyroidism was a significant predictor for high loneliness score.

Background: With the onset of the spread of the Coronavirus around the world, the Saudi Ministry of Health has taken protective measures early to prevent the spread of the disease in the region, and the most effective of these measures is Quarantine and home isolation, which can have an impact on the individual's mental health. The purpose of this study is to assess the compliance of Quarantine in a family with an allergic and immunologically diseased child and its psychological impact on them. Methods: A cross-sectional study conducted between June-August 2020 was conducted via a selfreported online questionnaire that includes fear of COVID-19 scale for parents, Revised children's anxiety and depression scale to assess Quarantine's psychological effect, fear of getting the infection and also to know the family's attitude towards COVID-19 and public health measures. Results: This study included 4,436 participants, and the findings revealed that (13.3%) of participants had a child with allergies or immune diseases, (30.2%) had children between 6-10 years of age, the mean fear score was 18.74 ± 6.48 (7-35) which is nearly moderate;the mean values of the Child Anxiety and Depression Sub-Scale for Parents (RCADS) were 4.81 5.61 and 18.74 ± 6.48, respectively. This study showed a highly statistically significant positive relationship between the mean values for fear of COVID-19 Score scale and mean scores for child anxiety and depression (P =