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BackgroundHereditary angioedema (HAE) is a rare disease characterized by localized and self-limited angioedema (AE) attacks. A local increase of bradykinin (BK) mediates AE attacks in HAE, however the role of inflammation in HAE has been poorly explored We aim to analyze the role of inflammatory mediators in HAE patients during AE attacks.MethodsPatients with a confirmed HAE diagnosis due to C1 inhibitor deficiency (HAE-C1INH) or patients F12 gene mutations (HAE-FXII) attending to our outpatient clinic between November-2019 and May-2022 were included. Demographic and clinical characteristics were analyzed. Blood samples were collected both during symptom-free periods (baseline) and during HAE attacks, and acute phase reactants (APR), such as serum amyloid A (SAA), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), D-Dimer and white blood cells were measured.ResultsSeventy-eight patients were enrolled in the study, with a predominant representation of women (76%, n=59), and a mean age of 47.8 years (range 6–88). Among them, 67% (n=52) of patients had HAE-C1INH (46 classified as type 1 and 6 as type 2) while 33% (n=26) had HAE-FXII. During attack-free periods, the majority of patients exhibited normal levels of SAA, ESR, D-dimer, ACE and WCC. However, in a subset of patients (16% for SAA, 18% for ESR, and 14.5% for D-dimer), elevations were noted at baseline. Importantly, during HAE attacks, significant increases were observed in SAA in 88% of patients (p< 0.0001 vs. baseline), in ESR in 65% (p= 0.003 vs. baseline) and D-dimer in 71% (p=0.001 vs. baseline) of the patients. A comparison between baseline and acute attack levels in 17 patients revealed significant differences in SAA AA (p

Rehabilitation involves all types of patients, including people with schizophrenia. Schizophrenia is considered a complex syndrome characterized in general by fundamental and characteristic distortions of thinking and perception. The quality of life of a person with schizophrenia can be compromised by difficulty in carrying out their daily tasks and by the social stigma of their condition. The importance of training and sensitizing students in rehabilitation areas to this type of problem to improve the rehabilitation processes in which they will participate as future professionals involves empathy and the ability to communicate with these populations. It is possible through virtual reality to create immersive environments to simulate some psychotic symptoms characteristic of people with schizophrenia, such as visual hallucinations and hearing voices. The aim of this study was to test the effect of exposure to experiences characteristic of schizophrenia through two different types of immersive environments, graphical computational virtual reality and 360° video, on students from areas of social rehabilitation regarding empathy, social distance, and attitudes towards people with schizophrenia. Although the results were positive for the three parameters under study, no significant differences were found for each of them between the environments to which the participants were exposed. This study concluded that the choice between the two types of immersive environments should be based on the project’s objectives, the target audience’s needs, and available resources, rather than the type of environment itself, as their impact was similar.

Abstract There is a profile of patient with eosinophilic oesophagitis and atopic background, marked by the existence of IgE-mediated sensitizations. Our aim is to report the observed sensitivities to environmental and food allergens and panallergens in patients with eosinophilic oesophagitis with atopic background as well as characterizing other markers or analytical parameters. We suspect that the prevalence of sensitization to panallergens will be high and this will probably be relevant in terms of the onset and clinical course of the disease. We collated clinical and analytical data from 160 adult patients with a reported diagnosis of eosinophilic oesophagitis. These patients were studied between 1 January 2012 and 31 December 2020. During an initial visit skin tests were performed with full batteries of routine aero-allergens and foodstuffs. Patients were subsequently referred for blood test and determination of specific IgE, blood count and total IgE (in all cases), as well as eosinophilic cation protein and IMMUNOISAC in the centres in which this was available. We were able to detect a broad spectrum of sensitizations to environmental, foodstuffs and panallergens. The most common allergic disease was rhinoconjuntivitis. The sensitizations observed to foodstuffs were atypical for the adult population and were not responsible for manifestations compatible with immediate allergy. An important percentage of patients presented seasonal worsening of choking symptoms. We should be able to identify patients with eosinophilic oesophagitis and atopic background. Identifying this phenomenon would enable giving dietary and environmental recommendations as well as more specific and effective treatments to our patients.

BackgroundPolysomnography is the gold standard for measuring and detecting sleep patterns. In recent years, activity wristbands have become popular because they record continuous data in real time. Hence, comprehensive validation studies are needed to analyze the performance and reliability of these devices in the recording of sleep parameters. ObjectiveThis study compared the performance of one of the best-selling activity wristbands, the Xiaomi Mi Band 5, against polysomnography in measuring sleep stages. MethodsThis study was carried out at a hospital in A Coruña, Spain. People who were participating in a polysomnography study at a sleep unit were recruited to wear a Xiaomi Mi Band 5 simultaneously for 1 night. The total sample consisted of 45 adults, 25 (56%) with sleep disorders (SDis) and 20 (44%) without SDis. ResultsOverall, the Xiaomi Mi Band 5 displayed 78% accuracy, 89% sensitivity, 35% specificity, and a Cohen κ value of 0.22. It significantly overestimated polysomnography total sleep time (P=.09), light sleep (N1+N2 stages of non–rapid eye movement [REM] sleep; P=.005), and deep sleep (N3 stage of non-REM sleep; P=.01). In addition, it underestimated polysomnography wake after sleep onset and REM sleep. Moreover, the Xiaomi Mi Band 5 performed better in people without sleep problems than in those with sleep problems, specifically in detecting total sleep time and deep sleep. ConclusionsThe Xiaomi Mi Band 5 can be potentially used to monitor sleep and to detect changes in sleep patterns, especially for people without sleep problems. However, additional studies are necessary with this activity wristband in people with different types of SDis. Trial RegistrationClinicalTrials.gov NCT04568408; https://clinicaltrials.gov/ct2/show/NCT04568408 International Registered Report Identifier (IRRID)RR2-10.3390/ijerph18031106

Service-Learning (SL) is a powerful methodology to acquire competences and values in Higher Education. However, there is still no widespread use in Information and Computer Science (ICS) degrees where most of the subjects are focused on the development of theoretical and practical contents purely related to technical competences. In this paper, we show the structure of a SL methodology to develop Bachelor's Thesis: 1) definition of proposals considering all the competencies of the Bachelor's Thesis subject and the needs of entities; 2) development of applications using agile methodologies, and 3) assessment of the SL experience from students, entities and professors. We present an experience developed in the 2019/2020 academic year with two entities devoted to disfavoured people. The results show both the high technical and professional quality of the projects and the high satisfaction of entities and students. We hope that the development of applications with the collaboration of non-profit entities allows the acquisition of both specific and transversal competencies on ICS degrees at the same time enhancing the development of useful professional ones.

Background: Lower quantity and poorer sleep quality are common in most older adults, especially for those who live in a nursing home. The use of wearable devices, which measure some parameters such as the sleep stages, could help to determine the influence of sleep quality in daily activity among nursing home residents. Therefore, this study aims to analyse the influence of sleep and its changes concerning the health status and daily activity of older people who lived in a nursing home, by monitoring the participants for a year with Xiaomi Mi Band 2. Methods: This is a longitudinal study set in a nursing home in [Details omitted for double-anonymized peer reviewed]. The Xiaomi Mi Band 2 will be used to measure biomedical parameters and different assessment tools will be administered to participants for evaluating their quality of life, sleep quality, cognitive state, and daily functioning. Results: A total of 21 nursing home residents participated in the study, with a mean age of 86.38 ± 9.26. The main outcomes were that sleep may influence daily activity, cognitive state, quality of life, and level of dependence in activities of daily life. Moreover, environmental factors and the passage of time could also impact sleep. Conclusions: Xiaomi Mi Band 2 could be an objective tool to assess the sleep of older adults and know its impact on some factors related to health status and quality of life of older nursing homes residents. Trial Registration: NCT04592796 (Registered 16 October 2020) Available on: https://clinicaltrials.gov/ct2/show/NCT04592796.

Virtual Reality (VR) has been identified as one of the most promising resources for developing empathy towards stigmatized groups as it allows individuals to experience a situation close to reality from another person’s perspective. This quasi-experimental study aimed to examine the impact on empathy, knowledge, and attitudes towards people with schizophrenia of a VR simulation that reproduces the experience of psychotic symptoms while performing a cognitive task compared with watching a 2D video and, thus, how these experiences could reduce stigma towards people diagnosed with schizophrenia. The sample comprised of 102 higher education health students, distributed by the experimental and control groups. The impact of the program was measured by completing multiple questionnaires on levels of empathy, attitudes, and mental health knowledge. Both methods (VR and 2D video) were, to a certain extent, effective. However, VR was more effective at eliciting attitudes and knowledge change compared to the control group. These findings suggest that not only VR but also 2D videos could be interesting strategies to enhance empathy and improve attitudes towards people with schizophrenia in higher education health students.

Aims To determine the psychosocial impact of assistive technology(AT) based on robotics and artificial intelligence in the life of people with disabilities. Background The best match between any person with disabilities and its AT only can be gotten through a complete assessment and monitoring of his/her needs, abilities, priorities, difficulties and limitations. Without this analysis, it’s possible that the device won’t meet the individual’s expectations. Therefore, it is important that any project focused on the development of innovating AT for people with disabilities includes the perspective of outcome measures as an important phase of the research. In this sense, the integration of the assessment, implementation process and outcome measures is crucial to guarantee the transferability for the project findings and to get the perspective from the final user. Methods Pilot study, with prospective, longitudinal and analytical cohort. The study lasts from July 2020 until April 2023. The sample is formed by people with disabilities, ages from 2–21, that will participate from the first stage of the process (initial assessment of their abilities and needs) to the final application of outcome measures instruments (with a complete implication during the test of technology). Discussion Only with the active participation of the person is possible to carry out a user-centered approach. This fact will allow us to define and generate technological solutions that really adjust to the expectations, needs and priorities of the people with disabilities, avoiding the AT from being abandoned, with the consequent health and social spending. Trial registration Clinical Trials ID: NCT04723784; https://clinicaltrials.gov/.

Background: Despite the increase in the older-adults’ population and recognizing retirement as one of the most changeable life stages, most Spanish people do not perform a retirement preparation program. The adaptation and preparation for retirement are needed to ensure adequate active and healthy aging. Objectives: The study aims to know about the experience with the retirement process of a retired people’s group and understand the impact on their quality-of-life and behavior change of a Personalized Retirement Preparation Program using technological devices. Participants: People retired who have enjoyed paid employment and have never done a preparation program for retirement. Methods: The present study is a mixed design consisting of a Participatory-Action-Research and a quasi-experimental study. The qualitative tools used were semi-structured individual, group interviews, and field diary, and the quantitative tools were the sociodemographic variables sheet and the EuroQol-5D-5 L scale. Action plan development: It was developed with 26 participants divided into three groups, during five presential sessions, and using technological resources. Data analysis: It consists of the comparison pre-post action plan along with analysis of the interview transcriptions with a parallel convergent analysis between qualitative and quantitative data. Ethics: The Research Ethics Committee of Galicia has approved the protocol.

Introducción:La rehabilitación cardiovascular (RCV) se considera como un modelo de atención integral que representa una continuidad en la prevención secundaria de las enfermedades cardiovasculares con múltiples beneficios. Objetivo: Unir las diferentes guías a nivel mundial para lograr determinar la existencia de un consenso mundial para la atención de los pacientes en rehabilitación cardiaca. Materiales y métodos: Se realizaron búsquedas de las guías de diferentes países de todo el mundo, desde el año 2000 hasta Diciembre del año 2018. Dicha búsqueda fue realizada en diferentes bases de datos como: Scielo, Medline, Medscape, PubMed Central, EMBASE, Redalyc, DOAJ y OVID; también, se realizaron búsquedas en revistas especializadas y/o organizaciones académicas y científicas de 21 países. Resultados: Se encontraron 28 guías y/o documentos de 21 países diferentes a nivel mundial. Dichos documentos de RCV en EE.UU., Canadá y Europa recomiendan que los pacientes pasen del ejercicio aeróbico de resistencia moderada a vigorosa a lo largo del programa. Sin embargo, aquellos en el Reino Unido, Australia y Nueva Zelanda especifican ejercicios de menor intensidad y menos evaluación técnica de la capacidad funcional. Además, el 50% de los documentos recolectados, no presentan recomendaciones especiales y las que si, no dan recomendaciones especificas sobre su prescripción e intervención. Conclusiones: Existe un consenso donde se menciona que la RCV genera mejoras en la capacidad funcional, la fuerza física, factores de riesgo cardiovascular y calidad de vida. Pero, se evidencia una ausencia de recomendaciones globales sobre la intensidad y tipo de ejercicio en el entrenamiento de fuerza y HIIT en el área de rehabilitación cardíaca.

Project title: Occupational Therapy Approach to Sexuality in People with Acquired Brain Injury (ABI) in Subacute Stage. Design: Qualitative study with a phenomenological approach. Context of Study: The relevance of the occupational therapy approach to sexuality regarding people with acquired brain injury in the subacute stage. Objectives: General objective : Explore the perceptions of people with ABI, who are in a subacute situation, and their relatives and partners, about their assessment of the relevance of the approach toward sexuality during their occupational therapy intervention. Specific objectives : Describe and analyze the perspectives of users, family members, and partners about the importance of this activity and its relevance in daily life; what is included in the approach to sexuality; the differences that may arise between the perspectives of the participants according to gender; and the differences that may arise between the perspectives on the subject by age groups. Study Population and the Total Number of Participants: The study population is made up of people with ABI in the subacute stage who attend occupational therapy at the physical rehabilitation unit of a hospital in Spain, and their families and partners. The size of the sample is conditioned by the qualitative study’s design. The number of participants will be established when theoretical saturation of the data is reached. First results are now available.

Objectives: The Active Aging focuses on the participation of older people in social, economic, cultural, spiritual and civic affairs, not only in the ability to be physically and mentally active. Occupational Therapy with knowledge and tools can play a key role in promoting Active Aging. The aim was to study the relationship between Occupational Therapy and promoting Active Aging, from the perceptions of occupational therapists working in care resources at people over the city of A Coruna. Methodology: The study is part of qualitative research, within the phenomenological paradigm, using semistructured interview and field notebook as data collection techniques. The sample of the study is formed by 10 professionals of occupational therapy who work in care day centers and residences of A Coruña. Results: Despite the importance of Occupational Therapy in Active Aging programs, we can see in participants a significant lack of knowledge about the phenomenon, which is evident in the difficulty to justify their practice, as well as the benefits of the discipline for elderly. Conclusions: It is considered very important to include information and education in the curricula and training programs for health workers, revealing the basic principles of Active Aging. It is also very important to continue to work unwrapping delve into the relationship between Active Aging and Occupational Therapy.

Aims: Nowadays has been observed a progressive aging of the population which has increased the interest about retirement, as the duration of this will be longer and will affect labour, health and education systems, as well as the proper organization of society. The objective of this study is to explore and learn about the occupational experiences of older recently retired in the urban environment of the province of A Coruña. Methods: It has been used for the study the quantitative and qualitative research, being used as methods of data collection a questionnaire, a semi-structured interview and a field journal homemade. The sample consisted of 13 retired people. Results: There are inconsistencies between the results of the questionnaire and refer participants in the interview, because the retirement questionnaire give a positive meaning while in his speech is the opposite. Furthermore, they have limitations to understand the official concept of retirement and identify with him. Finally, it highlighted the influence of climate on occupational performance and the controversy about how leisure is understood as the environment in which the person lives (urban or rural). Conclusions: We conclude that the distribution of time is one of the most significant changes in retirement, existing contradictions about the meaning given to it. The results also reflect the need for pre-retirement preparation, although initially many participants do not identify this need as their own

Objetivos: obtener un perfil sobre capacidad funcional y participación de personas con Enfermedades Neuromusculares (ENM), y determinar los recursos de apoyo necesarios para mejorar o mantener su grado de independencia. Metodología: estudio transversal con 24 personas con ENM. En la evaluación se emplearon la Medida de Independencia Funcional (FIM), un checklist de accesibilidad de la vivienda y un cuestionario específico. Resultados: muestra formada por catorce mujeres (58,3 %) y 10 hombres (41,7 %). Se obtuvo una media de 61,7 (DE=17,2) para la parte motora de FIM sobre 91, indicando un grado moderado de dependencia. El producto de apoyo (PA) más frecuentemente empleado fue la silla de ruedas (70,8 %). La mayoría de las viviendas (87,5 %) presentaban barreras arquitectónicas. Conclusiones: la evaluación concisa sobre necesidades de independencia de personas con ENM es fundamental para prescribir los recursos más adecuados para satisfacerlas. Este procedimiento se debe implementar en programas asistenciales, incluyendo la atención al cuidador.

The interactivity of an immersive environment comes up from the relationship that is established between the user and the system. This relationship results in a set of data exchanges between human and technological actors. The real-time biofeedback devices allow to collect in real time the biodata generated by the user during the exhibition. The analysis, processing and conversion of these biodata into multimodal data allows to relate the stimuli with the emotions they trigger. This work describes an adaptive model for biofeedback data flows management used in the design of interactive immersive systems. The use of an affective algorithm allows to identify the types of emotions felt by the user and the respective intensities. The mapping between stimuli and emotions creates a set of biodata that can be used as elements of interaction that will readjust the stimuli generated by the system. The real-time interaction generated by the evolution of the user’s emotional state and the stimuli generated by the system allows him to adapt attitudes and behaviors to the situations he faces.

Background: Presently the use of technological devices such as wearable devices has emerged. Physical activity monitoring with wearable sensors is an easy and non-intrusive approach to encourage preventive care for older adults. It may be useful to follow a continuous assessment of the risk of falling. The objective is to explore the relationship between the daily activity measured by Xiaomi Mi Band 2 and the risk of falling of older adults residing in or attending care facilities. Methods: A cross-sectional study was conducted on three different institutions located in Galicia (autonomous community) (Spain). Results: A total of 31 older adults were included in the study, with a mean age of 84 ± 8.71 years old. The main findings obtained were that a greater number of steps and distance could be related to a lower probability of falling, of dependency in basic activities of daily living, or of mobility problems. Conclusions: The importance of focusing on daily steps, intrinsically related to the objective assessment of daily physical activity, is that it is a modifiable factor that impacts different aspects of health and quality of life.

The advances achieved in recent decades regarding cardiac surgery have led to a new risk that goes beyond surgeons’ dexterity; postoperative hours are crucial for cardiac surgery patients and are usually spent in intensive care units (ICUs), where the patients need to be continuously monitored to adjust their treatment. Clinical decision support systems (CDSSs) have been developed to take this real-time information and provide clinical suggestions to physicians in order to reduce medical errors and to improve patient recovery. In this review, an initial total of 499 papers were considered after identification using PubMed, Web of Science, and CINAHL. Twenty-two studies were included after filtering, which included the deletion of duplications and the exclusion of titles or abstracts that were not of real interest. A review of these papers concluded the applicability and advances that CDSSs offer for both doctors and patients. Better prognosis and recovery rates are achieved by using this technology, which has also received high acceptance among most physicians. However, despite the evidence that well-designed CDSSs are effective, they still need to be refined to offer the best assistance possible, which may still take time, despite the promising models that have already been applied in real ICUs.

Le syndrome métabolique est une maladie très dangereuse, car elle affecte les gens donc multisystémiques qui souffrent, à l'obésité abdominale et la résistance à l'insuline, un facteur de progression; parce que cela crée un ensemble d'anomalies métaboliques, ce qui conduit à des professionnels de la santé ne le traiter comme une seule maladie, mais comme l'association de plusieurs facteurs qui peuvent se produire simultanément ou séquentiellement dans le même individu. De là vient la nécessité de renforcer les recommandations générales sur le contrôle du poids, diminution de la consommation de sucres simples, l'augmentation de l'activité physique, ce qui réduit les graisses saturées, les gras trans, le cholestérol, et des niveaux élevés de sodium. Son étiologie est pas encore clair, cependant, crée le besoin de savoir comment et pourquoi il existe actuellement une forte prévalence de ce syndrome, ainsi que son association avec augmentation de la mortalité due aux maladies cardiovasculaires et les maladies cérébrovasculaires.

The exploitation of electronic health records (EHRs) has multiple utilities, from predictive tasks and clinical decision support to pattern recognition. Artificial Intelligence (AI) allows to extract knowledge from EHR data in a practical way. In this study, we aim to construct a Machine Learning model from EHR data to make predictions about patients. Specifically, we will focus our analysis on patients suffering from respiratory problems. Then, we will try to predict whether those patients will have a relapse in less than 6, 12 or 18 months. The main objective is to identify the characteristics that seem to increase the relapse risk. At the same time, we propose an exploratory analysis in search of hidden patterns among data. These patterns will help us to classify patients according to their specific conditions for some clinical variables.

This work focuses on interactivity as one of the essential factors for creating immersive environments, particularly interactivity that generates involuntary responses over which the user does not have conscious control. A dynamic and adaptive model was designed to analyze and define the data flow generated by bio stimuli for the design of interactive immersive environments.

This study proposes solutions to help people with phobias through the use of virtual environments that allow a contact between the subjects and these phobias. Using neurofeedback, the systems, depending on the emotional state of the user, adapt the scenarios allowing more or less intensity. The phobias these systems treat are social phobia, entomophobia and claustrophobia. The solutions have been developed using Unity, Muse 2 and Vive HTC.

This work focus on the study of solutions that using video 360 and virtual reality that allow children’s and older people that are away of their family environments for various reasons to be able to feel they are participating at family or school events. The solutions proposed should deliver a strong sense of presence to the users and the interface must be friendly. The validation will be made by user observation and inquiries.

The research intends to gather on a IoT Platform, a set of data existing in the ecosystem - in the universe of things, from sources and types of diverse origin coming from messages, devices, sensors, etc. These structured and related data allow us to generate indicators of anxiety about which we intend to act, either preventively or proactively, through information for an individual's awareness and self-regulation.

This work explores the potential of the use of interactive and immersive technologies to create impactful experiences that generate emotions, contributing to the process of activation or somatic excitation that triggers links that strengthen cognitive functions. It is intended to demonstrate to what extent the use of immersive environments, by generating a strong emotional load, contribute in a more effective way to the empathy construct about Schizophrenia.

We studied the small mammal assemblage (bats, marsupials and rodents) of Parque Nacional Chaco and Capitán Solari (Chaco Province, Argentina) based on captures and analysis of owl pellets. Twenty-one species were recorded during a brief survey, including two marsupials, seven bats, and twelve rodents. In addition, we documented the first occurrence of the bat Lasiurus ega in the Chaco Province, and extended to the southwest the distribution of the didelphid marsupial Cryptonanus chacoensis and the oryzomyine rodent Oecomys sp. We also provided a second occurrence site in the ents Calomys laucha and Holochilus brasiliensis. Identified taxa belonged to species that are typical of the Humid Chaco ecoregion of Argentina.

A new robustness analysis framework is proposed where robustness of a solution in a decision aiding process is measured as the distance from that solution to an expected outcome, chosen by the decision-aiding analyst. The framework is explained by the application of the TODIM method of multicriteria decision aiding to the problem of predicting rental ranges for properties in a Chilean city. Therefore, the robustness concern concentrates on changes in criteria weights as well as in trade-off rates, as they are defined in the method. Two main contributions are introduced: a local robustness measure, defined in terms of a distance among rankings; and a global robustness measure, as an adaptation of the minimax-regret rule to select a global robust solution, i.e. a ranking produced by TODIM.

We explore a portfolio constructive model, formulated in terms of satisfaction of a given set of technical requirements, with the minimum number of projects and minimum redundancy. An algorithm issued from robust portfolio modeling is adapted to a vector model, modifying the dominance condition as convenient, in order to find the set of nondominated portfolios, as solutions of a bicriteria integer linear programming problem. In order to improve the former algorithm, a process finding an optimal solution of a monocriteria version of this problem is proposed, which is further used as a first feasible solution aiding to find nondominated solutions more rapidly. Next, a sorting process is applied on the input data or information matrix, which is intended to prune nonfeasible solutions early in the constructive algorithm. Numerical examples show that the optimization and sorting processes both improve computational efficiency of the original algorithm. Their limits are also shown on certain complex instances.

Background: Hereditary angioedema (HAE) is a rare disease characterized by localized and self-limited angioedema (AE) attacks. A local increase of bradykinin (BK) mediates AE attacks in HAE, however the role of inflammation in HAE has been poorly explored We aim to analyze the role of inflammatory mediators in HAE patients during AE attacks. Methods: Patients with a confirmed HAE diagnosis due to C1 inhibitor deficiency (HAE-C1INH) or patients F12 gene mutations (HAE-FXII) attending to our outpatient clinic between November-2019 and May-2022 were included. Demographic and clinical characteristics were analyzed. Blood samples were collected both during symptom-free periods (baseline) and during HAE attacks, and acute phase reactants (APR), such as serum amyloid A (SAA), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), D-Dimer and white blood cells were measured. Results: Seventy-eight patients were enrolled in the study, with a predominant representation of women (76%, n=59), and a mean age of 47.8 years (range 6-88). Among them, 67% (n=52) of patients had HAE-C1INH (46 classified as type 1 and 6 as type 2) while 33% (n=26) had HAE-FXII. During attack-free periods, the majority of patients exhibited normal levels of SAA, ESR, D-dimer, ACE and WCC. However, in a subset of patients (16% for SAA, 18% for ESR, and 14.5% for Ddimer), elevations were noted at baseline. Importantly, during HAE attacks, significant increases were observed in SAA in 88% of patients (p< 0.0001 vs. baseline), in ESR in 65% (p= 0.003 vs. baseline) and D-dimer in 71% (p=0.001 vs. baseline) of the patients. A comparison between baseline and acute attack levels in 17 patients revealed significant differences in SAA AA (p<0. 0001), ESR (p<0.0001) and D-dimer (p= 0.004). No significant differences were observed in CRP (p=0.7), ACE (p=0.67) and WCC (p=0.54). These findings remained consistent regardless of HAE type, disease activity or location of angioedema. Conclusion: The systemic increase in APR observed during HAE attacks suggests that inflammation extends beyond the localized edematous area. This finding underscores the potential involvement of inflammatory pathways in HAE and highlights the need for further investigation into their role in the pathophysiology of HAE. [ABSTRACT FROM AUTHOR]