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Abstract Background Factors associated with suicide attempts during the antecedent illness trajectory of bipolar disorder (BD) and schizophrenia (SZ) are poorly understood. Methods Utilizing the Rochester Epidemiology Project, individuals born after 1985 in Olmsted County, MN, presented with first episode mania (FEM) or psychosis (FEP), subsequently diagnosed with BD or SZ were identified. Patient demographics, suicidal ideation with plan, self-harm, suicide attempts, psychiatric hospitalizations, substance use, and childhood adversities were quantified using the electronic health record. Analyses pooled BD and SZ groups with a transdiagnostic approach given the two diseases were not yet differentiated. Factors associated with suicide attempts were examined using bivariate methods and multivariable logistic regression modeling. Results A total of 205 individuals with FEM or FEP (BD = 74, SZ = 131) were included. Suicide attempts were identified in 39 (19%) patients. Those with suicide attempts during antecedent illness trajectory were more likely to be female, victims of domestic violence or bullying behavior, and have higher rates of psychiatric hospitalizations, suicidal ideation with plan and/or self-harm, as well as alcohol, drug, and nicotine use before FEM/FEP onset. Based on multivariable logistic regression, three factors remained independently associated with suicidal attempts: psychiatric hospitalization (OR = 5.84, 95% CI 2.09–16.33, p

This study explores the encapsulation in alginate/bentonite beads of two metal(loid)-resistant bacterial consortia (consortium A: Pseudomonas sp. and Bacillus sp.; consortium B: Pseudomonas sp. and Bacillus sp.) from the Atacama Desert (northern Chile) and Antarctica, and their influence on physiological traits of Chenopodium quinoa growing in metal(loid)-contaminated soils. The metal(loid) sorption capacity of the consortia was determined. Bacteria were encapsulated using ionic gelation and were inoculated in soil of C. quinoa. The morphological variables, photosynthetic pigments, and lipid peroxidation in plants were evaluated. Consortium A showed a significantly higher biosorption capacity than consortium B, especially for As and Cu. The highest viability of consortia was achieved with matrices A1 (3% alginate and 2% bentonite) and A3 (3% alginate, 2% bentonite and 2.5% LB medium) at a drying temperature of 25 °C and storage at 4 °C. After 12 months, the highest viability was detected using matrix A1 with a concentration of 106 CFU g−1. Further, a greenhouse experiment using these consortia in C. quinoa plants showed that, 90 days after inoculation, the morphological traits of both consortia improved. Chemical analysis of metal(loid) contents in the leaves indicated that consortium B reduced the absorption of Cu to 32.1 mg kg−1 and that of Mn to 171.9 mg kg−1. Encapsulation resulted in a significant increase in bacterial survival. This highlights the benefits of using encapsulated microbial consortia from extreme environments, stimulating the growth of C. quinoa, especially in soils with metal(loid) levels that can be a serious constraint for plant growth.

Abstract Background Surgery and treatment for colorectal cancer (CRC) in the elderly patient increase the risk of developing post-operative complications, losing functional independence, and worsening health-related quality of life (HRQoL). There is a lack of high-quality randomized controlled trials evaluating the potential benefit of exercise as a countermeasure. The primary aim of this study is to evaluate the effectiveness of a home-based multicomponent exercise program for improving HRQoL and functional capacity in older adults undergoing CRC surgery and treatment. Methods This randomized, controlled, observer-blinded, single-center trial aims to randomize 250 patients (>74 years) to either an intervention or a control group (i.e., usual care). The intervention group will perform an individualized home-based multicomponent exercise program with weekly telephone supervision from diagnosis until three months post-surgery. The primary outcomes will be HRQoL (EORTC QLQ-C30; CR29; and ELD14) and functional capacity (Barthel Index and Short Physical Performance Battery), which will be assessed at diagnosis, at discharge, and one, three, and six months after surgery. Secondary outcomes will be frailty, physical fitness, physical activity, inspiratory muscle function, sarcopenia and cachexia, anxiety and depression, ambulation ability, surgical complications, and hospital length of stay, readmission and mortality. Discussion This study will examine the effects of an exercise program in older patients with CRC across a range of health-related outcomes. Expected findings are improvement in HRQoL and physical functioning. If proven effective, this simple exercise program may be applied in clinical practice to improve CRC care in older patients. Trial registration ClinicalTrials.gov ID: NCT05448846.

Abstract Expectations can lead to prediction errors of varying degrees depending on the extent to which the information encountered in the environment conforms with prior knowledge. While there is strong evidence on the computationally specific effects of such prediction errors on learning, relatively less evidence is available regarding their effects on episodic memory. Here, we had participants work on a task in which they learned context/object-category associations of different strengths based on the outcomes of their predictions. We then used a reinforcement learning model to derive subject-specific trial-to-trial estimates of prediction error at encoding and link it to subsequent recognition memory. Results showed that model-derived prediction errors at encoding influenced subsequent memory as a function of the outcome of participants’ predictions (correct vs. incorrect). When participants correctly predicted the object category, stronger prediction errors (as a consequence of weak expectations) led to enhanced memory. In contrast, when participants incorrectly predicted the object category, stronger prediction errors (as a consequence of strong expectations) led to impaired memory. These results highlight the important moderating role of choice outcome that may be related to interactions between the hippocampal and striatal dopaminergic systems.

BackgroundThere is evidence suggesting racial disparities in diagnosis and treatment in bipolar disorder (BD) and schizophrenia (SZ). The purpose of this study is to compare psychiatric diagnoses and psychotropic use preceding a first episode of mania (FEM) or psychosis (FEP) in racially diverse patients.MethodsUsing a comprehensive medical records linkage system (Rochester Epidemiology Project, REP), we retrospectively identified individuals diagnosed with BD or SZ and a documented first episode of mania or psychosis. Illness trajectory before FEP/FEM were characterized as the time from first visit for a mental health complaint to incident case. Pathways to care and clinical events preceding FEP/FEM were compared based on subsequent incident case diagnosis (BD or SZ) and self-reported race (White vs. non-White).ResultsA total of 205 (FEM = 74; FEP = 131) incident cases were identified in the REP. Duration of psychiatric antecedents was significantly shorter in non-White patients, compared to White patients (2.2 ± 4.3 vs. 7.4 ± 6.6 years; p

SARS-Cov2 s, caused a high mortality in patients with some degree of immunosuppression, like those that receive a hematopoietic progenitor transplant. Since December 2020, several vaccines have been developed having been key in decreasing complications and mortality in this group of patients. Different articles have described the presence of thrombopenia related to the administration of vaccines, however, there are few data on the occurrence of neutropenia as a side effect after administration. We present several cases of neutropenia (defined as absolute neutrophil count (ANC) less than 2,000/mm3), after vaccination in hematopoietic progenitor transplant (HPT) recipients performed in our center during 2021.

Abstract Background The incorporation of genetic variables into risk scores for predicting venous thromboembolic events (VTE) could improve their capacity to identify those patients for whom thromboprophylaxis would be most beneficial. Proof‐of‐concept of this is provided by the TiC‐ONCO score for predicting the risk of VTE in patients with solid tumours. Our aim was to develop a similarly improved tool—the TiC‐LYMPHO score—for predicting VTE in patients with lymphoma. Methods In a retrospective observational study of 208 patients with lymphoma, 31 (14.9%) were found to have experienced an episode of VTE either at the time of diagnosis or over the next 6 months. Clinical variables associated with VTE, determined via logistic regression analysis, plus the same genetic variables included in the TiC‐ONCO score, were used to build the TiC‐LYMPHO score algorithm. The sensitivity, specificity, predictive values and AUC of the TiC‐LYMPHO, the Khorana and ThroLy scores were compared in the same population. Results The TiC‐LYMPHO score showed a significantly higher AUC, sensitivity and NPV (0.783, 95.35% and 97.98% respectively) than the other scores. The ThroLy score showed a significantly higher specificity (96.43% vs. 54.49%; p

Efficient processing of the visual environment necessitates the integration of incoming sensory evidence with concurrent contextual inputs and mnemonic content from our past experiences. To examine how this integration takes place in the brain, we isolated different types of feedback signals from the neural patterns of non-stimulated areas of the early visual cortex in humans (i.e., V1 and V2). Using multivariate pattern analysis, we showed that both contextual and time-distant information, coexist in V1 and V2 as feedback signals. In addition, we found that the extent to which mnemonic information is reinstated in V1 and V2 depends on whether the information is retrieved episodically or semantically. Critically, this reinstatement was independent on the retrieval route in the object-selective cortex. These results demonstrate that our early visual processing contains not just direct and indirect information from the visual surrounding, but also memory-based predictions.

River biofilms are biological consortia of autotrophs and heterotrophs colonizing most solid surfaces in rivers. Biofilm composition and biomass differ according to the environmental conditions, having different characteristics between systems and even between river habitats. Artificial substrata (AS) are an alternative for in situ or laboratory experiments to handle the natural variability of biofilms. However, specific research goals may require decisions on colonization time or type of substrata. Substrata properties (i.e., texture, roughness, hydrophobicity) and the colonization period and site are selective factors of biofilm characteristics. Here we describe the uses of artificial substrata in the assessment of ecological and ecotoxicological responses and propose a decision tree for the best use of artificial substrata in river biofilm studies. We propose departing from the purpose of the study to define the necessity of obtaining a realistic biofilm community, from which it may be defined the colonization time, the colonization site, and the type of artificial substratum. Having a simple or mature biofilm community should guide our decisions on the colonization time and type of substrata to be selected for the best use of AS in biofilm studies. Tests involving contaminants should avoid adsorbing materials while those ecologically oriented may use any AS mimicking those substrata occurring in the streambed. • We review the utilization of different artificial substrata to colonize biofilm in river ecology and ecotoxicology. • We propose a decision tree to guide on selecting the appropriate artificial substrata and colonization site and duration. • Type of artificial substrata (material, size, shape...) and colonization duration are to be decided according to the specific purpose of the study.

Approximately 2000 indigenous students at Institución Educativa Privada Prescott in Puno, located in the Andes high on the Altiplano of Lake Titicaca, have been instructed in Transcendental Meditation. In this study, we examine the impact of home isolation during the COVID-19 pandemic on physical, cognitive, and emotional health, and school performance for a group of 54 meditating students, and contrast these results to a comparison group of 53 meditating students who reported their health and learning prior to the pandemic. The study is the first to consider the association of home isolation on students practicing meditation in a group: (A) at the same time of day and in the same place as part of their daily school routine and (B) during online sessions at the same time of day but in a different place. Findings indicate both approaches to group meditation before and during the pandemic produced favourable results for health and school performance.

Researchers have suggested that the recognition memory effects resulting from two separate attentional manipulations—attentional boost and perceptual degradation—may share a common cause; namely a transient up-regulation of attention at the time of encoding that leads to enhanced memory performance at the time of retrieval. Prior research has demonstrated that inducing two similar transient shifts of attention simultaneously produces redundant performance in memory. In the present study, we sought to evaluate the combined influence of the attentional boost and perceptual degradation on recognition memory. If these two effects share a common cause, then we ought to observe a redundancy in memory performance, such that these two factors interact. Yet, across four experiments we fail to observe such a redundancy in recognition memory. We evaluate these results using the limited resource model of attention and speculate on how combining transient shifts of attention may produce redundant memory performance in the one case, but non-redundant performance in the other case.

Background: The literature pays low attention to functional changes during acute illness in older patients. Our main objectives were to separately describe the different functional changes occurring before and after hospital admission in oldest old medical patients, to investigate their association with mortality, and identify predictors associated with in-hospital failure to recover function.Methods: Secondary analysis of data from a prospective cohort study conducted in a tertiary teaching hospital. The study followed the STROBE criteria. The sample included 604 consecutive patients aged 65 or older hospitalized for acute illness, discharged alive, and not fully dependent at baseline. Activities of daily living measured at baseline, admission, and discharge were used to classify patients into four functional trajectories depending on whether they decline or remain stable between baseline and admission (prehospital) and whether they decline, remain stable, or recover baseline function between admission and discharge (in-hospital). Multivariate models were used to test the association between functional trajectories with mortality, and predictors for in-hospital recovery.Results: Functional trajectories were: “stable-stable” (18%); “decline-recovery” (18%); “decline-no recovery” (53%); “in-hospital decline” (11%). Prehospital decline occurred in 75% and 64% were discharged with worse function than baseline. “In-hospital decline” and “decline-no recovery” trajectories were independently associated with higher 6- and 12-month mortality. Extent of prehospital decline and dementia were predictors of failure to in-hospital recovery.Conclusion: In acutely ill older people, differentiating between prehospital and in-hospital functional changes has prognostic implications. Lack of functional regain at discharge is associated with higher mortality at 6- and 12-months.

The synthesis and characterization of two new water soluble 2,6-bis(imidazolylmethyl)-4-methylphenoxy-containing perylenediimides, PDI-1 and PDI-2, are described. These compounds demonstrate a high fluorescence quantum yield in water and were investigated as potential photosensitizers for generating reactive oxygen species with applications in anticancer activities. The HeLa cell line (VPH18) was used to evaluate their efficacy. Fluorescence microscopy was employed to confirm the successful internalization of PDI-1 and PDI-2, while confocal microscopy revealed the specific locations of both PDIs within the lysosomes and mitochondria. In vitro studies were conducted to evaluate the anticancer activity of PDI-1 and PDI-2. Remarkably, these photosensitizers demonstrated a significant ability to selectively eliminate cancer cells when exposed to a specific light wavelength. The water solubility, high fluorescence quantum yield, and selective cytotoxicity of these PDIs toward cancer cells highlight their potential as effective agents for targeted photodynamic therapy. In conclusion, the findings presented here provide a strong foundation for the future exploration and optimization of PDI-1 and PDI-2 as effective photosensitizers in photodynamic therapy, potentially leading to improved treatment strategies for cancer patients.

BackgroundInterleukin 6 (IL6) levels and SARS-CoV-2 viremia have been correlated with COVID-19 severity. The association over time between them has not been assessed in a prospective cohort. Our aim was to evaluate the relationship between SARS-CoV-2 viremia and time evolution of IL6 levels in a COVID-19 prospective cohort.MethodsSecondary analysis from a prospective cohort including COVID-19 hospitalized patients from Hospital Universitario La Princesa between November 2020 and January 2021. Serial plasma samples were collected from admission until discharge. Viral load was quantified by Real-Time Polymerase Chain Reaction and IL6 levels with an enzyme immunoassay. To represent the evolution over time of both variables we used the graphic command twoway of Stata.ResultsA total of 57 patients were recruited, with median age of 63 years (IQR [53–81]), 61.4% male and 68.4% Caucasian. The peak of viremia appeared shortly after symptom onset in patients with persistent viremia (more than 1 sample with > 1.3 log10 copies/ml) and also in those with at least one IL6 > 30 pg/ml, followed by a progressive increase in IL6 around 10 days later. Persistent viremia in the first week of hospitalization was associated with higher levels of IL6. Both IL6 and SARS-CoV-2 viral load were higher in males, with a quicker increase with age.ConclusionIn those patients with worse outcomes, an early peak of SARS-CoV-2 viral load precedes an increase in IL6 levels. Monitoring SARS-CoV-2 viral load during the first week after symptom onset may be helpful to predict disease severity in COVID-19 patients.

En este trabajo analizamos la estructura de los libros-registro de esclavos conservados en el Archivo General de Indias y su potencial como fuente de investigación para el estudio de la trata con las Indias de Castilla en el siglo XVI. Siguiendo el hilo conductor que los propios libros señalan, identificaremos las fases del sistema de licencias, los diferentes perfiles de los intervinientes y las pautas de actuación asociadas a cada uno de ellos, siempre tomando como telón de fondo el caso de la comunidad vasca.

Abstract Background Patients with cancer have been shown to have a higher risk of clinical severity and mortality compared to non-cancer patients with COVID-19. Patients with hematologic malignancies typically are known to have higher levels of immunosuppression and may develop more severe respiratory viral infections than patients with solid tumors. Data on COVID-19 in patients with hematologic malignancies are limited. Here we characterize disease severity and mortality and evaluate potential prognostic factors for mortality. Methods In this population-based registry study, we collected de-identified data on clinical characteristics, treatment and outcomes in adult patients with hematologic malignancies and confirmed severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection within the Madrid region of Spain. Our case series included all patients admitted to 22 regional health service hospitals and 5 private healthcare centers between February 28 and May 25, 2020. The primary study outcome was all-cause mortality. We assessed the association between mortality and potential prognostic factors using Cox regression analyses adjusted for age, sex, comorbidities, hematologic malignancy and recent active cancer therapy. Results Of 833 patients reported, 697 were included in the analyses. Median age was 72 years (IQR 60–79), 413 (60%) patients were male and 479 (69%) and 218 (31%) had lymphoid and myeloid malignancies, respectively. Clinical severity of COVID-19 was severe/critical in 429 (62%) patients. At data cutoff, 230 (33%) patients had died. Age ≥ 60 years (hazard ratios 3.17–10.1 vs 2 comorbidities (1.41 vs ≤ 2), acute myeloid leukemia (2.22 vs non-Hodgkin lymphoma) and active antineoplastic treatment with monoclonal antibodies (2·02) were associated with increased mortality; conventional chemotherapy showed borderline significance (1.50 vs no active therapy). Conversely, Ph-negative myeloproliferative neoplasms (0.33) and active treatment with hypomethylating agents (0.47) were associated with lower mortality. Overall, 574 (82%) patients received antiviral therapy. Mortality with severe/critical COVID-19 was higher with no therapy vs any antiviral combination therapy (2.20). Conclusions In this series of patients with hematologic malignancies and COVID-19, mortality was associated with higher age, more comorbidities, type of hematological malignancy and type of antineoplastic therapy. Further studies and long-term follow-up are required to validate these criteria for risk stratification.

Background: Hand-foot syndrome (HFS) is a common adverse reaction associated with capecitabine chemotherapy that significantly affects the quality of life of patients. This study evaluates the safety and effectiveness of a topical heparin (TH) treatment on the clinical manifestations and anatomopathological alterations of capecitabine-induced HFS. In addition, we performed proteome profiling of skin biopsies obtained from patients with HFS at baseline and after heparin treatment. Methods: Patients with grade ⩽ 2 HFS associated with capecitabine were included in this study. The primary end point was the effectiveness of TH in reducing HFS of any grade. Clinical improvement was evaluated by clinicians, and an improvement was perceived by patients who performed a weekly visual analog scale questionnaire. Secondary end points included a comparative histological analysis and protein expression in skin biopsies at baseline and after 3 weeks of HT treatment. Proteomic profiling was carried out using quantitative isobaric labelling and subsequently validated by a T-array. Results: Twenty-one patients were included in the study. The median TH treatment time was 7.6 weeks (range = 3.6–41.6 weeks), and the median response time was 3.01 weeks (95% CI = 2.15–3.97). At the end of treatment, 19 of 21 patients (90.48%) responded to treatment with a decrease in one or more grades of HFS. None of the patients experienced adverse effects related to TH usage, nor did they suspend chemotherapy treatment. The main findings observed in skin biopsies after treatment were a decrease in hyperkeratosis and lymphocytic infiltrates. The proteomic analysis showed altered expression of 34 proteins that were mainly related to wound healing, cell growth, and the immune response. Conclusion: Based on our results, topical heparin is an effective and safe treatment for clinical manifestations of HFS, probably due to the restauration of skin homeostasis after heparin treatment, as supported by our proteomics-derived data. Trial registration: EudraCT 2009-018171-13

Este artículo ofrece una investigación sobre la traducción subtitulada al español de la variante dialectal African American Vernacular English (AAVE) y para su ilustración se emplean ejemplos de la serie estadounidense The Wire. En primer lugar, se analiza la vital importancia que cobra el AAVE (además de otras variedades dialectales como el bawlmer, propio de Baltimore) en el desarrollo de la serie, hasta el punto que, sin estas variedades lingüísticas el programa televisivo perdería buena parte de su bien construida esencia. A continuación, se trata desde una perspectiva teórica cómo afrontar los múltiples problemas de la traducción dialectal de The Wire; para ello, se emplea la tipología propuesta de Marco Borillo (2002), que, posteriormente, nos ayuda a analizar algunos rasgos léxicos y morfosintácticos propios del AAVE y su posterior traducción al español. Estos rasgos seleccionados se ilustran con diferentes ejemplos de diálogos de la primera temporada de la serie, en los que se coteja la versión original inglesa con la traducción oficial al español del canal televisivo HBO. Todas estas ilustraciones vienen acompañadas de unas propuestas de traducción subtitulada alternativas a la versión oficial, cuya finalidad es ayudar a obtener en la versión española un tono lingüístico similar al de la versión inglesa.

A paucity of data in school children generally, and in non-Western schools specifically, related to health, school performance, and practice of meditation necessitated this study. The fact that almost no prior research of this type has been conducted in Latin America makes the present investigation especially worthwhile. This mostly quantitative study was carried out with 91 randomly selected school children, ranging in age from 11 to 16 years, in a remote Peruvian town in the central Andean mountains called Huay-Huay. Using a 47-question, paper-and-pencil instrument to ask students about their experience with meditation in four categories (i.e., physical health, cognitive health, emotional health, and school performance), this observational study considered whether or not the practice of meditation had a self-reported impact on student personal health and academic life, and if so to what extent. Data indicate that a majority of children in Huay-Huay reported benefits across all measures, and these were apparently stronger when students practiced meditation more regularly. Qualitative reports support these conclusions. Gender and grade level did not appear to influence this outcome.

Introduction: Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide. Liver transplantation offers good results in its treatment, however the shortage of donors has forced the use of other therapies, such as transarterial chemoembolization (TACE), whose therapeutic scheme is not completely standardized. Objective: To evaluate the response to the first TACE, the indicators of success of the therapy and the decompensations associated with its use. Methods: Retrospective observational study. 76 patients were included. Variables such as sociodemographic, clinical and HCC stages were included. Response to TACE was assessed by post-treatment LIRADS classification. Descriptive statistics were used for the analysis. Results: 60% men, the median age was 64 years (51-81), 63% Child A, average MELD-Na 10 points. 33% associated with NASH. 47% of the patients reached non-viability after the first TACE, 30% required two TACE, 15% three TACE and 7% four TACE. 58% in Barcelona stage A, 43% within the Milan criteria and 60% within the San Francisco criteria. 6% presented decompensations after the 1st TACE. The characteristics of the patients who reached non-viability versus those who remained viable are presented in Table 1. Conclusion: Most patients require two TACEs to achieve tumor non-viability. The main indicators of response to TACE were tumor burden and MELD-Na score> 8.

Abstract Aim To propose a predictive model of procedural and emotional stress in clinical placements while testing self‐efficacy as a possible mediator factor. Design The study used an exploratory correlational design. Method A total of 334 nursing students completed the KEZKAK—stress in clinical practice, AG—general self‐efficacy and CEA—academic overload questionnaires, along with one about leadership. Sociodemographic information was also included. Results Confirmatory factor analyses and internal consistency reliabilities were satisfactory in all questionnaires. Procedural stress and emotional stress were confirmed by KEZKAK [χ2 (674) = 1,555.58, p = .001; χ2/df = 2.308, CFI = .90, IFI = 91, RMSEA = .06]. The structural equation method for procedural stress and emotional stress had an acceptable fit. They revealed that academic level influenced the perception of leadership and academic overload in both procedural stress and emotional stress. General self‐efficacy only mediated emotional stress. Hospital unit acted independently as a predictor of procedural stress.

This paper aims to analyse the role played by Basque seamen in the XVIth Century Castilian slave trade, focusing on two key figures: the slave carrier and the merchant. This proposal is not intended to be exhaustive, but it suggests a starting point for future studies. We would also like to raise a couple of names or profiles and to explore the research possibilities of this subject arising from the Sevillian archives, mainly the Archivo General de Indias and the Archivo Histórico Provincial de Sevilla.

Current computer systems are accumulating huge amounts of information in several application domains. The outbreak of COVID-19 has increased rekindled interest in the use of data mining techniques for the analysis of factors that are related to the emergence of an epidemic. Data mining techniques are being used in the analysis and interpretation of information, which helps in the discovery of patterns, planning of isolation policies, and even predicting the speed of proliferation of contagion in a viral disease such as COVID-19. This research provides a comprehensive study of various data mining algorithms that are used in conjunction with epidemiological prediction models. The document considers that there is an opportunity to improve or develop tools that offer an accurate prognosis in the management of viral diseases through the use of data mining tools, based on a comparative study of 35 research papers.

Los fotolibros constituyen uno de los soportes fundamentales para la difusión de la fotografía y su estudio en tiempos recientes se ha considerado como una recuperación de la “otra historia” del medio. Este artículo trata sobre cinco publicaciones de Henri Cartier-Bresson, Paul Graham, Carlos Spottorno, Roger Grasas y Federico Clavarino, cuyo tema fundamental es la idea de Europa. El análisis de la obra de estos autores muestra cómo se ha tratado un mismo tema, desde la posguerra que siguió a la Segunda Guerra Mundial hasta trabajos más recientes realizados tras la crisis de 2008. Esto permite percibir cuestiones fundamentales en la configuración de una identidad europea no exenta de conflictos: la herencia del pasado, las brechas norte-sur o este-oeste, los clichés culturales, o la forma en que el ejercicio del poder afecta a los ciudadanos. El artículo identifica los planteamientos conceptuales de cada uno de los fotolibros, así como los elementos temáticos y estéticos que los han definido, en estrecha conexión con sus respectivos contextos históricos y creativos.

Abstract Background The daily diary Urticaria Activity Score (UAS) and its weekly score (UAS7) are widely used to assess signs and symptoms in patients with chronic spontaneous urticaria (CSU). The objective of this study was to assess the psychometric properties of a Spanish version of the once-daily UAS. Methods Observational study in patients ≥18 years old receiving usual care for CSU (daily or almost daily occurrence of generalized hives or angioedema for ≥6 weeks). Patients were included consecutively and completed the UAS, EQ-5D, and the Chronic Urticaria Quality of Life scale (CU-Q2oL) at two study visits 6 weeks apart. On each occasion, the UAS was completed once-daily for 7 consecutive days to be able to calculate the UAS7 score. Psychometric properties of reliability, construct validity, and responsiveness were assessed. The Minimal Important Difference (MID) was estimated for the UAS7 using anchor- and distribution-based approaches. Results Data from 166 patients was available for analysis (mean age 49 years, 65.7% female). Floor (5.4% of patients with the lowest possible score) and ceiling (1.2%) effects were low; 15% of patients had missing values. Internal consistency and test-retest reliability were good (Cronbach’s alpha of 0.83 and an ICC of 0.84, respectively). Convergent validity was demonstrated through the pattern of correlations with the EQ-5D and CU-Q2oL and known groups’ validity was demonstrated by the instrument’s ability to discriminate between patients with different overall levels of urticaria severity, with between-group effect-sizes (ES) ranging from 0.36 to 1.19. The UAS7 proved responsive to change with effect sizes ranging from 0.3 to 1.52 in patients reporting improvement or deterioration in overall urticaria status. The MID for the UAS7 score was estimated at 7–8 points, on a scale of 0–42. Conclusions The Spanish version of the UAS score has demonstrated a robust psychometric performance in patients with CSU managed in conditions of usual care. It can therefore be considered a suitable instrument to assess disease activity in clinical practice in Spanish-speaking patients. The Spanish version’s reliability and validity are similar to those reported for other language versions of the once- and twice-daily variants of the UAS.

Personality is a unique trait that distinguishes an individual. It includes an ensemble of peculiarities on how people think, feel, and behave that affects the interactions and relationships of people. Personality is useful in diverse areas such as marketing, training, education, and human resource management. There are various approaches for personality recognition and different psychological models. Preceding work indicates that linguistic analysis is a promising way to recognize personality. In this work, a proposal for personality recognition relying on the dominance, influence, steadiness, and compliance (DISC) model and statistical methods for language analysis is presented. To build the model, a survey was conducted with 120 participants. The survey consisted in the completion of a personality test and handwritten paragraphs. The study resulted in a dataset that was used to train several machine learning algorithms. It was found that the AdaBoost classifier achieved the best results followed by Random Forest. In both cases a feature selection pre-process with Pearson’s Correlation was conducted. AdaBoost classifier obtained the average scores: accuracy = 0.782, precision = 0.795, recall = 0.782, F-measure = 0.786, receiver operating characteristic (ROC) area = 0.939.

Background. The purpose of this study was to gather information on the current assessment and management of patients with moderate-to-severe AD in routine daily practice. Methods. A cross-sectional two-round Delphi survey with the participation of dermatologists and allergologists throughout Spain was conducted. They completed a 46-item questionnaire, and consensus was defined when responses of ≥80% of participants coincided in the categories of a 5-point Likert scale for that item. Results. A total of 105 specialists (aged 40–59 years) completed the two rounds. Participants agreed regarding the consideration of AD as a multifaceted disease and the differences in clinical presentation of AD according to the patient’s age. It is recommendable to perform a skin biopsy to exclude early stage T-cell cutaneous lymphoma, psoriasis, or dermatitis herpetiformis, among others (99.1%). Also, consensus was reached regarding the use of the SCORAD index to quantify the severity of the disease (86.7%), the use of wet wraps to increase the effect of topical corticosteroids (90.4%), the usefulness of proactive treatment during follow-up (85.6%) and tacrolimus ointment (91.2%) to reduce new flares, and the fact that crisaborole is not the treatment of choice for severe AD (92.4%). AD was not considered a contraindication for immunotherapy in patients with allergic respiratory diseases (92.4%). In patients with severe AD, the use of immune response modifier drugs (97.6%) or phototherapy (92.8%) does not sufficiently cover their treatment needs. Consensus was also obtained regarding the role of the new biologic drugs (93.6%) targeting cytokines involved in the Th2 inflammatory pathway (92.0%) and the potential role of dupilumab as first-line treatment (90.4%) in moderate-to-severe AD patients. Conclusion. This study contributes a reference framework to the care of AD patients. There is no diagnostic test or biomarkers to direct treatment or to assess the severity of the disease, and many therapeutic challenges remain.

The work of the artist Antoni Tàpies (1923-2012) has been widely studied from different disciplines, including his analytical and syncretic vision. This article tries to analyze one of its aesthetic keys: in particular, the conceptualization of its idea process, using the synthesis that appears in the graphic story "The most beautiful painting in the world" published by Ralph Herrmanns in 1970, in which Tàpies is represented as a character-artist. The study of this graphic story also allows us to advance in the study of some educational variables that can intervene in the teaching-learning processes of the arts, such as the artist's relationship with the educational intention that appears as a moral in the story-tale. In this moral of a fable, as a conclusion or educational synthesis, Tàpies tries to express his aesthetic thinking about the creative process, represented in his artistic work.

Livestock raising is an important sector of the Colombian economy, which will face serious challenges in the next decade, including adaptation to and mitigation of climate change. Colombia must change the model of livestock production in a very short time by freeing up areas of pasture for other uses and focusing intensified livestock production in suitable zones. Despite the urgency and the magnitude of the required changes, only isolated small-scale initiatives exist. Colombia therefore has the challenge to scale-up these initiatives1, but at present it has no program designed to achieve this objective. We started by analyzing the policies, actors, and existing initiatives in Colombia. We then sought to understand the potential for and the limitations to scaling-up promising initiatives to face the challenges of climate change in the livestock sector. We identified the key elements from previous initiatives and classified them into the conceptual spaces identified in the theory of scaling-up. These are the spaces in matters of: policy, fiscal and financial matters, institutional capacity, learning, partnerships, and technical matters, emphasizing the importance of the technical dimension. Finally, we propose some elements for the design of Colombia's national program of livestock raising.

This work examined the capability of Imperata cylindrica to respond, tolerate and accumulate Cu when growing at high Cu concentration (300 mg kg−1 of substrate) at different times of exposure (2, 14 and 21 days). The Cu accumulation in plants was examined by atomic absorption spectroscopy (AAS) and Cu localized by Scanning Electron Microscopy-Energy Dispersive X-Ray spectroscopy. Additionally, the phenolic compound identifications and concentrations were determined using liquid chromatography coupled to mass spectrometry. Our results showed that root biomass decreased significantly at high Cu levels, with a greater decrease at 21 days (39.8% less biomass in comparison to control). The root showed 328 mg Cu kg−1 dry weight at 21 days of exposure to Cu, being the tissue that accumulates most of the Cu. Lipid peroxidation was a clear indicator of Cu stress, principally in shoots. The exposure to Cu significantly increased the synthesis of phenolic compounds in shoots of plants exposed 21 days to Cu, where 5-caffeoylquinic acid reached the highest concentrations. Our results support that I. cylindrica is a Cu accumulator plant in root organs with a medium level of accumulation (between 200–600 mg Cu kg−1 biomass), which can tolerate the exposure to high Cu levels by means of increasing the synthesis of phenolic compound in shoots, suggesting a potential use as phytoremediation tool in Cu polluted environments.

Based on the construction of a dialogue between the Colombian writer Hector Abad Faciolince’s book Traiciones de la memoria and the standpoints of certain theoreticians of world historiography, the article explores the methodological and conceptual contributions of this study for the craft of the historian. Despite having been created as a literary work, with no historical pretensions, Abad Faciolince’s text presents important suggestions and points of encounter with the ways of conceiving the historical mission of the new cultural history.

Voltametric sensors formed by the combination of a sulfur-substituted zinc phthalocyanine (ZnPcRS) and gold nanoparticles capped with tetraoctylammonium bromide (AuNPtOcBr) have been developed. The influence of the nature of the interaction between both components in the response towards catechol has been evaluated. Electrodes modified with a mixture of nanoparticles and phthalocyanine (AuNPtOcBr/ZnPcRS) show an increase in the intensity of the peak associated with the reduction of catechol. Electrodes modified with a covalent adduct-both component are linked through a thioether bond-(AuNPtOcBr-S-ZnPcR), show an increase in the intensity of the oxidation peak. Voltammograms registered at increasing scan rates show that charge transfer coefficients are different in both types of electrodes confirming that the kinetics of the electrochemical reaction is influenced by the nature of the interaction between both electrocatalytic materials. The limits of detection attained are 0.9 × 10−6 mol∙L−1 for the electrode modified with the mixture AuNPtOcBr/ZnPcRS and 1.3 × 10−7 mol∙L−1 for the electrode modified with the covalent adduct AuNPtOcBr-S-ZnPcR. These results indicate that the establishment of covalent bonds between nanoparticles and phthalocyanines can be a good strategy to obtain sensors with enhanced performance, improving the charge transfer rate and the detection limits of voltammetric sensors.

The endophytic strain Chaetomium cupreum isolated from metal-contaminated soil was inoculated in Eucalyptus globulus roots to identify genes involved in metal stress response and plant growth promotion. We analyzed the transcriptome of E. globulus roots inoculated with C. cupreum. De novo sequencing, assembly, and analysis were performed to identify molecular mechanisms involved in metal stress tolerance and plant growth promotion. A total of 393,371,743 paired-end reads were assembled into 135,155 putative transcripts. It was found that 663 genes significantly changed their expression in the presence of treatment, of which 369 were up-regulated and 294 were down-regulated. We found differentially expressed genes (DEGs) encoding metal transporters, transcription factors, stress and defense response proteins, as well as DEGs involved in auxin biosynthesis and metabolism. Our results showed that the inoculation of C. cupreum enhanced tolerance to metals and growth promotion on E. globulus. This study provides new information to understand molecular mechanisms involved in plant−microbe interactions under metals stress.

In soils multi-contaminated with heavy metal and metalloids, the establishment of plant species is often hampered due to toxicity. This may be overcome through the inoculation of beneficial soil microorganisms. In this study, two arsenic-resistant bacterial isolates, classified as Pseudomonas gessardii and Brevundimonas intermedia, and two arsenic-resistant fungi, classified as Fimetariella rabenhortii and Hormonema viticola, were isolated from contaminated soil from the Puchuncaví valley (Chile). Their ability to produce indoleacetic acid and siderophores and mediate phosphate solubilization as plant growth-promoting properties were evaluated, as well as levels of arsenic resistance. A real time PCR applied to Triticum aestivum that grew in soil inoculated with the bacterial and fungal isolates was performed to observe differences in the relative expression of heavy metal stress defense genes. The minimum inhibitory concentration of the bacterial strains to arsenate was up to 7000 mg·L−1 and that of the fungal strains was up to 2500 mg·L−1. P. gessardi was able to produce siderophores and solubilize phosphate; meanwhile, B. intermedia and both fungi produced indoleacetic acid. Plant dry biomass was increased and the relative expression of plant metallothionein, superoxide dismutase, ascorbate peroxidase and phytochelatin synthase genes were overexpressed when P. gessardii plus B. intermedia were inoculated.

Around 1950 there was an intense debate about U.S. aid to Francoist Spain. American magazines such as Look and Life devoted attention to the Spanish issue, and used photo essays to visually argue their positions. This article seeks to examine how this controversy was created through these photo essays that appeared in American magazines, the reaction of the Spanish public, and the response to American critics by magazines such as Mundo Hispánico and Semana. These cases demonstrate how part of the debate was also an image campaign structured around photo essays published in said illustrated magazines.

Este ensayo aborda el estudio de la enseñanza de la traducción literaria en el ámbito universitario desde una perspectiva práctica y metodológica. Una vez enmarcado el alcance del estudio de la disciplina dentro de lo establecido por PACTE para la adquisición de (sub)competencias, se tratan tres aspectos esenciales en la práctica de la traducción literaria y su aplicación en el aula y a la enseñanza de la traducción: i) el tratamiento del estilo de la obra en la traducción literaria; ii) la correcta aproximación a la diferenciación entre el texto narrativo y el dialogado de la obra; y iii) aspectos relacionados con la traducción y el mercado editorial. Para alcanzar los objetivos metodológicos y prácticos propuestos, cada uno de los aspectos estudiados aparecen ilustrados con ejemplos del aula de traducción literaria.

Secuencias

Le cinéma documentaire apporte une perspective privilégiée pour décrire la réalité urbaine. Durant les régimes totalitaires, cinéma et architecture sont devenus des moyens de propagande privilégiés. Ce travail prétend étudier les relations qui existent entre les représentations urbaines des régimes de Franco et Mussolini, durant leur brève période de coexistence, à travers deux documentaires, Carbonia (pour l’Italie) et Un día en Santiago (pour l’Espagne).

Partiendo de las críticas que el historiador Carlo M. Cipolla hace a ciertas tendencias historiográficas en el sugestivo texto Allegro ma non troppo, el artículo expone puntos de vista alrededor de las nuevas formas de hacer historia, fundamentadas en el giro lingüístico, el giro crítico y la influencia posmoderna, que colocan en tela de juicio el papel del historiador como reconstructor de la realidad.

Voltammetric sensors chemically modified with combinations of two electrocatalytic materials: tetraoctylammonium bromide capped gold nanoparticles (AuNPNBr) and a sulphur containing zinc phthalocyanine derivative (ZnPcRS) are reported. The electrocatalytic effects in the detection of catechol have been analyzed in sensors obtained by direct mixing (AuNPNBr/ZnPcRS) and in sensors modified with an adduct where both components are linked covalently (AuNPNBr-S-ZnPcR). Results demonstrate that the nature of the interaction between both components modifies the electrocatalytic properties. The AuNPNBr/ZnPcRS mixture improves the electron transfer rate of the catechol reduction, with limits of detection of 10−6 M. The covalent adduct AuNPNBr-S-ZnPcR enhances the response rate of the oxidation of the catechol with limits of detection of 10−7 M.