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9 pages, 5 figures, 1 table, supplementary materials https://doi.org/10.1016/j.watres.2023.120044.-- Data availability: Data will be made available on request, The purpose of this study was to investigate the occurrence of microplastics (MPs) in drinking water in Spain by comparing tap water from different locations using common sampling and identification procedures. We sampled tap water from 24 points in 8 different locations from continental Spain and the Canary Islands by means of 25 μm opening size steel filters coupled to household connections. All particles were measured and spectroscopically characterized including not only MPs but also particles consisting of natural materials with evidence of industrial processing, such as dyed natural fibres, referred insofar as artificial particles (APs). The average concentration of MPs was 12.5 ± 4.9 MPs/m3 and that of anthropogenic particles 32.2 ± 12.5 APs/m3. The main synthetic polymers detected were polyamide, polyester, and polypropylene, with lower counts of other polymers including the biopolymer poly(lactic acid). Particle size and mass distributions were parameterized by means of power law distributions, which allowed performing estimations of the concentration of smaller particles provided the same scaling parameter of the power law applies. The calculated total mass concentration of the identified MPs was 45.5 ng/L. The observed size distribution of MPs allowed an estimation for the concentration of nanoplastics (< 1 µm) well below the ng/L range; higher concentrations are not consistent with scale invariant fractal fragmentation. Our findings showed that MPs in the drinking water sampled in this work do not represent a significant way of exposure to MPs and would probably pose a negligible risk for human health, The authors acknowledge the financial support provided by Plastics Europe and that of the Spanish Government, Ministerio de Ciencia e Innovación, grants PID2020-113769RB-C21/C22., With the institutional support of the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2019-000928-S)

Background: Studies have confirmed the ubiquitous presence of microplastics in every environmental compartment, and their number is rising year by year. Despite the fact that important efforts are being made in many countries to try to reduce microplastics contamination, it is very likely that their presence will continue to increase since plastic degradation is a long-term procedure. Current scientific data in this field is only the tip of a huge iceberg in which hand in hand research with scientists of different disciplines is absolutely necessary to draw a clear map of their origin, transport dynamics, distribution and effects. Methods: A brief overview (perspective article) of current research topics on microplastics, the problems that they must face as well as those gaps that should be solved in the future are reviewed. Results: Standardized and validated methodologies for microplastics quantification and identification are needed. The analysis of organic and inorganic contaminants retained onto microplastics is also a key issue. The study of the presence, behavior, and fate of microplastics in the environment (in all the environmental compartments) as well as the toxicity and dietary exposure studies are also highly necessary. Conclusion: A better understanding of the concentration, source, and hazards of microplastics in every environmental compartment is still needed, especially in the terrestrial environment and in the atmosphere. There is also the need of applying harmonized and validated analytical methodologies to provide feasible results and to allow a suitable comparison.

Soils play a very important role in ecosystems sustainability, either natural or agricultural ones, serving as an essential support for living organisms of different kinds. However, in the current context of extremely high plastic pollution, soils are highly threatened. Plastics can change the chemical and physical properties of the soils and may also affect the biota. Of particular importance is the fact that plastics can be fragmented into microplastics and, to a final extent into nanoplastics. Due to their extremely low size and high surface area, nanoplastics may even have a higher impact in soil ecosystems. Their transport through the edaphic environment is regulated by the physicochemical properties of the soil and plastic particles themselves, anthropic activities and biota interactions. Their degradation in soils is associated with a series of mechanical, photo-, thermo-, and bio-mediated transformations eventually conducive to their mineralisation. Their tiny size is precisely the main setback when it comes to sampling soils and subsequent processes for their identification and quantification, albeit pyrolysis coupled with gas chromatography-mass spectrometry and other spectroscopic techniques have proven to be useful for their analysis. Another issue as a consequence of their minuscule size lies in their uptake by plants roots and their ingestion by soil dwelling fauna, producing morphological deformations, damage to organs and physiological malfunctions, as well as the risks associated to their entrance in the food chain, although current conclusions are not always consistent and show the same pattern of effects. Thus, given the omnipresence and seriousness of the plastic menace, this review article pretends to provide a general overview of the most recent data available regarding nanoplastics determination, occurrence, fate and effects in soils, with special emphasis on their ecological implications.

In this work, several eutectic mixtures formed by fenchol and acetic acid at seven molar ratios (between 4:1 and 1:4) were characterized and studied for the first time for their possible application as extraction solvents in dispersive liquid-liquid microextraction based on the solidification of the floating organic droplet (DLLME-SFO). A group of 13 emerging contaminants (gemfibrozil, bisphenol F, bisphenol A, 17β-estradiol, testosterone, estrone, levonorgestrel, 4

A chain-shattering polymer (CSP) has been proposed as a microdispersive solid-phase extraction (μdSPE) sorbent in a proof-of-concept study of degradable materials for analytical purposes. The responsive CSP was synthesized from 1,3,5-tris(bromomethyl)-2-nitrobenzene acting as the self-immolative trigger responsive unit and 2,6-naphthalenedicarboxylic acid as aromatic linker to enhance noncovalent aromatic interactions with the analytes. The CSP was characterized and applied as a μdSPE sorbent of a group of plasticizers, which were selected as model analytes, from different types of environmental water samples (tap, waste, and spring waters). Gas chromatography coupled to mass spectrometry detection was used for analyte determination. Mean recovery values were in the range of 80%–118% with RSD values below 22%. After the extraction, the polymer could be efficiently degraded by UV irradiation or by chemical reduction, recovering the aromatic linker. This work has proved the potential of CSPs as recyclable sorbents, paving the way to more environmentally benign analytical procedures., C.O.-Z. and D.S. would like to thank the Spanish Ministry of Universities for the FPU fellowship. M.D.P. would like to thank the ACIISI and the European Social Fund (ESF) Canary Islands Integrated Operational Program 2014-2020, Area 3 Priority Theme 74 (85%), for a predoctoral grant. J.G.-S. would like to thank the ACIISI for the Catalina Ruiz contract at the Universidad de La Laguna (85% cofinanced from European Social Fund). The authors would like to acknowledge the ACIISI (Project ProID2021010111) and Ministerio de Ciencia e Innovación (PGC2018-094503-B-C21) for financial support, as well as the General Research Services (SEGAI) of the Universidad de La Laguna for the surface characterization measurements.

Oil residues have been frequently found on the coasts all over the world as a result of different accidental releases. Their partial evaporation and solidification onto the coastal rocks can produce the formation of a new solid structure forming an agglomerate with other materials, mainly microplastics (though wood, glass, sand and rocks were also found), yielding to a new plastic formation, name herein for the first time as "plastitar". These new formations have been found in several of the islands of the Canary Islands archipelago (Spain). Their study has shown that these new formations can be permanently attached to the rock, occupying even a 56% of the sampled area with an heterogeneous distribution. It was also observed that the studied plastitar was composed mainly of tar and polyethylene (90.6% of the studied particles) and polypropylene (9.4% of the studied particles) microplastics, primarily fragments (82.5%), pellets (15.7%) and lines (1.8%). The ever more frequent presence of plastics and, in particular, microplastics in coastal environments can lead to the common occurrence of these new plastic formations (probably present in other parts of the world), which long-term effects on the coasts should be further investigated.

In this work, a natural deep eutectic solvent (NADES) composed of L-menthol:acetic acid 1:1 (molar ratio) was applied for the first time as extraction solvent for the dispersive liquid-liquid micro...

In the present study, the ammonium formate version of the QuEChERS method, considered highly advantageous in relation to instrument maintenance and other issues, was applied for the first time to extract a group of twelve phthalic acid esters (PAEs, i.e. dipropyl phthalate, DPP; diisobutyl phthalate, DIBP; dibutyl phthalate, DBP; diisopentyl phthalate, DIPP; di-n-pentyl phthalate, DNPP; dihexyl phthalate, DHP; butyl benzyl phthalate, BBP; dicyclohexyl phthalate, DCHP; di(2-ethylhexyl) phthalate, DEHP; di-n-octyl phthalate, DNOP; diisononyl phthalate, DINP; and diisodecyl phthalate, DIDP) and one adipate (di(2-ethylhexyl) adipate, DEHA) from two species of fish (Scomber colias and Katsuwonus pelamis) and one of squid (Loligo gahi). The method was validated in terms of linearity, trueness and matrix effects. Determination coefficients (R

In this work, the ammonium formate version of the QuEChERS method has been applied for the first time to the extraction of a group of nine phthalic acid esters and one adipate from three types of coffee (maximum intensity, intermediate intensity and decaffeinated) prepared from coffee capsules, using gas chromatography coupled to mass spectrometry for analytes separation and determination. Matrix-matched calibration showed good linearity with determination coefficients (R

Microplastic research constitutes nowadays a very interesting and challenging research field since more and more studies are showing that plastic particles are present in every environmental compartment (water, air, soil and biota) in which they are causing important effects that still need to be fully understood. The study of their presence, behavior and fate in the environment is extremely necessary to solve such puzzle. In this context, chromatography is currently playing a very important role, since it is being used to determine the composition of microplastics (in particular those with an extremely low size), to study their sorption behavior as well as to analyze the organic contaminants that they retain during their travel through the environment, among other issues. This review article pretends to provide an overview of such relevant applications, in particular, focusing on works published in the last ten years, as well as to highlight the potential of chromatography as part of this relevant research field.

Current trends in Analytical Chemistry are focused on the development of more sustainable and environmentally friendly procedures. However, and despite technological advances at the instrumental level having played a very important role in the greenness of the new methods, there is still work to be done regarding the sample preparation stage. In this sense, the implementation of new materials and solvents has been a great step towards the development of “greener” analytical methodologies. In particular, the application of deep eutectic solvents (DESs) has aroused great interest in recent years in this regard, as a consequence of their excellent physicochemical properties, general low toxicity, and high biodegradability if they are compared with classical organic solvents. Furthermore, the inclusion of DESs based on natural products (natural DESs, NADESs) has led to a notable increase in the popularity of this new generation of solvents in extraction techniques. This review article focuses on providing an overview of the applications and limitations of DESs in solvent-based extraction techniques for food analysis, paying especial attention to their hydrophobic or hydrophilic nature, which is one of the main factors affecting the extraction procedure, becoming even more important when such complex matrices are studied.

In this work, the microplastic content of sediments collected in July 2020 between 5 and 7 m depth was studied in four locations of La Palma island (Canary Islands, Spain). At each sampling location, three samples were taken parallel to the shoreline. The microplastic content in each sampling corer was studied every 2.5 cm depth after digestion with a H2O2 solution followed by flotation in a saturated NaCl solution. Visualization of the final filtrates under a stereomicroscope revealed that all the sediment samples evaluated contained mostly microfibers (98.3%) which were mainly white/colorless (86.0%) and blue (9.8%), with an average length of 2423 ± 2235 (SD) mm and an average concentration of 2682 ± 827 items per kg of dry weight, being the total number of items found 1,019. Fourier Transform Infrared microscopy analysis of 13.9% (n = 139) of the microfibers also showed that they were mainly cellulosic (81.3%). No significant differences were found between the depths of the sediment. However, significant differences were found between the number of fibers from the sampling sites at the east and west of the island. Such variability could be driven by the winds and ocean mesoscale dynamics in the area. This study confirms the wide distribution of microfibers in sediments from an oceanic island like La Palma, providing their first report in marine sediments of the Canary Islands., SI

Sea urchins are highly abundant in the marine ecosystem where they graze limiting algal biomass and also serving as food for other predators. In this work, the presence of microplastics in the digestive tracts and gonads of 33 Diadema africanum sea urchins collected at two sampling points in Tenerife (Canary Islands, Spain) was studied. After separation and digestion of the digestive tracts and the gonads, the visualization of the filtrates under the stereomicroscope revealed the presence of 320 items which were microfibers (97.5%), fragments (1.9%) and films (0.6%), mainly blue (43.3 and 47.0% in the two sampling points, Tajao and El Poris, respectively) and translucent white (32.5 and 39.5%, respectively). Statistical analysis revealed that there were no significative differences in the contents of gonads and digestive tracts between both sampling locations. Regarding microfibers lengths, significative differences were only observed between the two sampling points, not between tissues. μRaman analysis showed that they were mainly cellulosic (46.0%), polypropylene (24.3%) and polyethylene terephthalate (24.3%). This study confirms for the first time the presence of microplastics in sea urchins from the Macaronesian region and also from Spain.

Foodomics is the discipline aimed at studying the prevention of diseases by food, identifying chemical, biological and biochemical food contaminants, determining changes in genetically modified foods, identifying biomarkers able to confirm the authenticity and quality of foods or studying the safety, quality and traceability of foods, among other issues. It is mainly based on the use of genomic, transcriptomic, proteomic and metabolomic tools, among others, in order to understand the effect of food on animals and humans at the level of genes, messenger ribonucleic acid, proteins and metabolites. Since the first definition of Foodomics, a reasonable number of works have shown the extremely high possibilities of this discipline, which is highly based on the use of advanced analytical hyphenated techniques - especially for proteomics and metabolomics. This book chapter aims at providing a general description of the role of chromatographic and electromigration techniques that are currently being applied to achieve the main objectives of Foodomics, particularly in the proteomic and metabolomic fields, since most published works have been focused on these approaches, and to highlight relevant applications.

Plastic litter dispersed in the different environmental compartments represents one of the most concerning problems associated with human activities. Specifically, plastic particles in the micro and nano size scale are ubiquitous and represent a threat to human health and the environment. In the last few decades, a huge amount of research has been devoted to evaluate several aspects of micro/nano-plastic contamination: origin and emissions, presence in different compartments, environmental fate, effects on human health and the environment, transfer in the food web and the role of associated chemicals and microorganisms. Nevertheless, despite the bulk of information produced, several knowledge gaps still exist. The objective of this paper is to highlight the most important of these knowledge gaps and to provide suggestions for the main research needs required to describe and understand the most controversial points to better orient the research efforts for the near future. Some of the major issues that need further efforts to improve our knowledge on the exposure, effects and risk of micro/nano-plastics are: harmonization of sampling procedures; development of more accurate, less expensive and less time-consuming analytical methods; assessment of degradation patterns and environmental fate of fragments; evaluating the capabilities for bioaccumulation and transfer to the food web; and evaluating the fate and the impact of chemicals and microorganisms associated with micro/nano-plastics. The major gaps in all sectors of our knowledge, from exposure to potentially harmful effects, refer to small size microplastics and, particularly, to the occurrence, fate and effects of nanoplastics.

[EN] The present work has studied the incidence and type of micro (1-5 mm), meso (5-25 mm) and macroplastics (>25 mm) that have reached Arenas Blancas beach, located in the north coast of El Hierro island, in the Canary Islands (Spain), from October 2019 to May 2020 (13 sampling dates with 3 sampling points each). Taking into consideration the three studied plastic debris fractions (macro, meso and microplastics), a total of 9206 items were found, which had a total weight of 1169.7 g and a concentration of 891.3 ± 91.5 items/m2 (118.3 ± 17.8 g/m2 and 2.3 ± 0.4 g/L). Regarding their colour, most of them were transparent/white/clear, especially in the microplastic fraction in which they accounted for a 68% of the total. Attenuated Total Reflectance Fourier Transform Infrared spectroscopy of meso and microplastic fractions indicated that most of the particles were either polypropylene and polyethylene followed by polystyrene in a much lower amount. In general, the total amount of plastic debris that arrives to the beach by the persistent oceanic current pattern linked to the easternmost branch of the North Atlantic Subtropical Gyre is comparable to those of the most contaminated beaches of the Canary Islands archipelago, suggesting that a new hotspot of plastic debris arrival has been found., Authors would like to thank Julio Herrero Segura (Dirección General de Lucha Contra el Cambio Climático y Medio Ambiente del Gobierno de Canarias), Carlos Samarín Bello (Dirección General de Lucha Contra el Cambio Climático y Medio Ambiente del Gobierno de Canarias), Diana Porto Lozano (Gestión y Planeamiento Territorial y Medioambiental, Gesplan, S.A.), Javier Pérez González (Gesplan, S.A.) y Vicente Benítez Cabrera (Dirección General de Lucha Contra el Cambio Climático y Medio Ambiente del Gobierno de Canarias) for the sampling facilities. J.G.S. would like to thank “Cabildo de Tenerife” for the Agustín de Betancourt contract at the Universidad de La Laguna. Authors acknowledge financial support of the Transnational Cooperation Program Azores-Madeira-Canary Islands for the “IMPLAMAC” project (reference number MAC2/1.1a/265) financed with FEDER funds. Authors would also like to thank the “General Support Research Services (SEGAI)” of the Universidad de La Laguna as well as May Gómez and Alicia Herrera from the EOMAR group at the University of Las Palmas de Gran Canaria, and Andrea Brito from the Universidad de La Laguna.

In this work, a natural deep eutectic solvent (NADES) consisting of L-menthol and acetic acid in a 1:1 molar ratio has been applied as extraction solvent for the dispersive liquid-liquid microextraction based on the solidification of the floating organic drop (DLLME-SFO) of a group of nine phthalic acid esters (dipropyl phthalate, DPP; butyl benzyl phthalate, BBP; dibutyl phthalate, DBP; dicyclohexyl phthalate, DCHP; diisopentyl phthalate, DIPP; di-n-pentyl phthalate, DNPP; di(2-ethylhexyl) phthalate, DEHP; diisononyl phthalate, DINP; and diisodecyl phthalate, DIDP) from three common infusions (camomile, pennyroyal mint, and linden teas) and three soft drinks (green tea, tonic, and lime and lemon drink), using dihexyl phthalate (DHP) and di-n-octyl phthalate (DNOP) as internal standards. After the DLLME-SFO procedure, analyses were carried out by high-performance liquid chromatography with UV detection. Method calibration showed good linearity for all the analytes and matrices, with determination coefficients (R2) higher than 0.9910. Relative recovery values were between 71 and 125 %, with relative standard deviation values in the range 1-22 % for the six types of samples, while the limits of quantification of the method were in the range 4.3-51.1 µg/L for infusions and in the range 3.5-33.3 µg/L for soft drinks. Several samples purchased in different local supermarkets were analysed, finding DPP, DBP, DIPP, DEHP and DINP, although only DPP, DBP and DEHP could be quantified in some of them.

Foodomics is the discipline aimed at studying the prevention of diseases by food, identifying chemical, biological and biochemical food contaminants, determining changes in genetically modified foods, identifying biomarkers able to confirm the authenticity and quality of foods or studying the safety, quality and traceability of foods, among other issues. It is mainly based on the use of genomic, transcriptomic, proteomic and metabolomic tools, among others, in order to understand the effect of food on animals and humans at the level of genes, messenger ribonucleic acid, proteins and metabolites. Since the first definition of Foodomics, a reasonable number of works have shown the extremely high possibilities of this discipline, which is highly based on the use of advanced analytical hyphenated techniques – especially for proteomics and metabolomics. This book chapter aims at providing a general description of the role of chromatographic and electromigration techniques that are currently being applied to achieve the main objectives of Foodomics, particularly in the proteomic and metabolomic fields, since most published works have been focused on these approaches, and to highlight relevant applications.

56 pages, 4 figures, 3 tables, Plastic litter dispersed in the different environmental compartments represents one of the most concerning problems associated with human activities. Specifically, plastic particles in the micro and nano size scale are ubiquitous and represent a threat to human health and the environment. In the last few decades, a huge amount of research has been devoted to evaluate several aspects of micro/nano-plastic contamination: origin and emissions, presence in different compartments, environmental fate, effects on human health and the environment, transfer in the food web and the role of associated chemicals and microorganisms. Nevertheless, despite the bulk of information produced, several knowledge gaps still exist. The objective of this paper is to highlight the most important of these knowledge gaps and to provide suggestions for the main research needs required to describe and understand the most controversial points to better orient the research efforts for the near future. Some of the major issues that need further efforts to improve our knowledge on the exposure, effects and risk of micro/nano-plastics are: harmonization of sampling procedures; development of more accurate, less expensive and less time-consuming analytical methods; assessment of degradation patterns and environmental fate of fragments; evaluating the capabilities for bioaccumulation and transfer to the food web; and evaluating the fate and the impact of chemicals and microorganisms associated with micro/nano-plastics. The major gaps in all sectors of our knowledge, from exposure to potentially harmful effects, refer to small size microplastics and, particularly, to the occurrence, fate and effects of nanoplastics

Stimuli-responsive materials, frequently designated as “smart/intelligent materials”, can modify their structure or properties by either a biological, physical, or chemical stimulus which, if properly controlled, could be used for specific applications. Such materials have been studied and exploited in several fields, like electronics, photonics, controlled drugs administration, imaging and medical diagnosis, among others, as well as in Analytical Chemistry where they have been used as chromatographic stationary phases, as part of sensors and for extraction purposes. This review article pretends to provide an overview of the most recent applications of these materials (mostly polymeric materials) in sample preparation for extraction purposes, as well as to provide a general vision of the current state-of-the-art of this field, their potential use and future applications., J.G.S. would like to thank “Cabildo de Tenerife” for the Agustín de Betancourt contract at the Universidad de La Laguna. The support of the Spanish Ministry of Science and Innovation (project PGC2018-094503-B-C21) is granted. This article is also based upon work from the Sample Preparation Task Force and Network supported by the Division of Analytical Chemistry of the European Chemical Society.

Pesticides are probably one of the chemical groups of compounds most widely studied and regulated worldwide. Despite the advances in agricultural practices that have taken place especially during the last years, the truth is that they are still being used in high amounts nearly in every country around the globe for different purposes. Their effects on human health have brought up the need to strictly monitor their presence in a wide variety of samples, especially in foods, to assess the potential hazards for humans and the environment. Of importance is their occurrence in milk or dairy products, as a consequence of their extremely high consumption, but also in pollen, in which it is clear nowadays that they are affecting bee’s presence.

In this work, the occurrence of microplastics (MPs) in irrigation recycled wastewaters (RWWs) and a desalinated brackish water (DBW) from the arid territory of Fuerteventura (Canary Islands, Spain) was studied. Besides, the presence of MPs in two types of soils (sandy-loam and clay-loamy; with no mulch film or fertilization with sewage sludge applied) irrigated with both water qualities was addressed. Results showed the prevalence presence of cellulosic and polyester microfibers (between 84.4 and 100%) of blue and transparent colors (up to 55.6 and 33.3%, respectively), with an average length of 786.9 ± 812.1 μm in the water samples. DBW had the lowest MP concentration (2.0 ± 2.0 items·L−1) while RWW showed concentrations up to 40.0 ± 19.0 items·L−1. Similarities were also observed between the MPs types and sizes found in both soils top layer (0–5 cm), with an average concentration three times greater in soil irrigated with RWW than in soil under DBW irrigation (159 ± 338 vs. 46 ± 92 items·kg−1, respectively). In addition, no MPs were extracted from non-irrigated/non-cultivated soils, suggesting agricultural activities as the unique source of MPs in soils of this arid area. Results show that RWWs constitute a potential source of MPs in irrigated soils that should be considered among other pros and cons linked to the use of this water quality in agricultural arid lands

In this work, Chromabond&reg, HLB was evaluated as an extraction sorbent of a group of seven phthalic acid esters (PAEs, i.e., dipropyl phthalate, DPP, dibutyl phthalate, DBP, diisopentyl phthalate, DIPP, di-n-pentyl phthalate, DNPP, butylbenzyl phthalate, BBP, dicyclohexyl phthalate, DCHP, and di(2-ethylhexyl)phthalate, DEHP) and one adipate (di(2-ethylhexyl) adipate, DEHA) from tap and waste water prior to gas chromatography-mass spectrometry. After the optimization of the extraction conditions (200 mg of sorbent conditioned with 10 mL of acetonitrile and 2 mL of Milli-Q water, extraction of 50 mL of water at pH 6.0, vacuum drying for 20 min and elution with 10 mL of ethyl acetate), a recovery study was developed at different concentration levels in each matrix, which revealed that most of the target analytes could be recovered between 75 and 112%, with relative standard deviation values for all of them below 20%. Matrix effect was evaluated, finding that matrix-matched calibration should be developed for most analytes in both matrices. The limits of quantification (LOQs) of the method were in the 0.82&ndash, 71 ng L&minus, 1 range. The developed method was also applied to the extraction of the target PAEs in different water samples finding some of them, in particular, DNPP in tap water samples, and BBP and DCHP in waste water, but below the LOQs of the method.

During the last years, the advances in the synthesis of nanomaterials have had an important impact in the Analytical Chemistry field, up to the point that an extremely high number of works in which they are used as nano-sorbents, among other applications, have been published. Regarding food contaminants analysis, such nano-sorbents have also found an important application field. This book chapter pretends to provide a general overview of the different preparation methods of those nano-sorbents that have been successfully applied for contaminants extraction from food as well as their most relevant and recent applications.

The introduction of the QuEChERS method in 2003 (standing from quick, easy, cheap, effective, rugged, and safe) could be considered a turning point in the development and application of sample pretreatment procedures, specially, but not limited to, in the pesticide analysis field. The high recovery values that it provides, the good sample cleanup together with the rest of its inherent advantages (rapidity, low cost, simplicity, etc.), are the cause of its high popularity and wide application in many laboratories worldwide. This chapter is aimed at providing an overview of the origin and development of the QuEChERS method, its most common variations, and selected applications in which its clear advantages over existing methods are demonstrated.