116 results on '"Jassat, W"'
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2. Characteristics and outcomes of an international cohort of 600 000 hospitalized patients with COVID-19
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Kartsonaki, C, Baillie, J, Barrio, N, Baruch, J, Beane, A, Blumberg, L, Bozza, F, Broadley, T, Burrell, A, Carson, G, Citarella, B, Dagens, A, Dankwa, E, Donnelly, C, Dunning, J, Elotmani, L, Escher, M, Farshait, N, Goffard, J, Goncalves, B, Hall, M, Hashmi, M, Heng, B, Ho, A, Jassat, W, Jimenez, M, Laouenan, C, Lissauer, S, Martin-Loeches, I, Mentre, F, Merson, L, Morton, B, Munblit, D, Nekliudov, N, Nichol, A, Oinam, B, Ong, D, Panda, P, Petrovic, M, Pritchard, M, Ramakrishnan, N, Ramos, G, Roger, C, Sandulescu, O, Semple, M, Sharma, P, Sigfrid, L, Somers, E, Streinu-Cercel, A, Taccone, F, Vecham, P, Vijayaraghavan, B, Wei, J, Wils, E, Wong, X, Horby, P, Rojek, A, Olliaro, P, Abbas, A, Abdukahil, S, Abdulkadir, N, Abe, R, Abel, L, Absil, L, Acharya, S, Acker, A, Adam, E, Adriao, D, Al Ageel, S, Ahmed, S, Ainscough, K, Airlangga, E, Aisa, T, Hssain, A, Tamlihat, Y, Akimoto, T, Akmal, E, Al Qasim, E, Alalqam, R, Alberti, A, Al-Dabbous, T, Alegesan, S, Alegre, C, Alessi, M, Alex, B, Alexandre, K, Al-Fares, A, Alfoudri, H, Ali, I, Ali, A, Shah, N, Alidjnou, K, Aliudin, J, Alkhafajee, Q, Allavena, C, Allou, N, Altaf, A, Alves, J, Alves, R, Amaral, M, Amira, N, Ampaw, P, Andini, R, Andrejak, C, Angheben, A, Angoulvant, F, Ansart, S, Anthonidass, S, Antonelli, M, Antunes De Brito, C, Apriyana, A, Arabi, Y, Aragao, I, Arancibia, F, Araujo, C, Arcadipane, A, Archambault, P, Arenz, L, Arlet, J, Arnold-Day, C, Arora, L, Arora, R, Artaud-Macari, E, Aryal, D, Asensio, A, Ashraf, M, Asif, N, Asim, M, Assie, J, Asyraf, A, Atique, A, Attanyake, A, Auchabie, J, Aumaitre, H, Auvet, A, Azemar, L, Azoulay, C, Bach, B, Bachelet, D, Badr, C, Baig, N, Baird, J, Bak, E, Bakakos, A, Bakar, N, Bal, A, Balakrishnan, M, Balan, V, Bani-Sadr, F, Barbalho, R, Barbosa, N, Barclay, W, Barnett, S, Barnikel, M, Barrasa, H, Barrelet, A, Barrigoto, C, Bartoli, M, Bashir, M, Basmaci, R, Basri, M, Battaglini, D, Bauer, J, Bautista Rincon, D, Bazan Dow, D, Bedossa, A, Bee, K, Begum, H, Behilill, S, Beishuizen, A, Beljantsev, A, Bellemare, D, Beltrame, A, Beltrao, B, Beluze, M, Benech, N, Benjiman, L, Benkerrou, D, Bennett, S, Bento, L, Berdal, J, Bergeaud, D, Bergin, H, Bernal Sobrino, J, Bertoli, G, Bertolino, L, Bessis, S, Bevilcaqua, S, Bezulier, K, Bhatt, A, Bhavsar, K, Bianco, C, Bidin, F, Bikram Singh, M, Bin Humaid, F, Bin Kamarudin, M, Bissuel, F, Biston, P, Bitker, L, Bitton, J, Blanco-Schweizer, P, Blier, C, Bloos, F, Blot, M, Boccia, F, Bodenes, L, Bogaarts, A, Bogaert, D, Boivin, A, Bolze, P, Bompart, F, Bonfasius, A, Borges, D, Borie, R, Bosse, H, Botelho-Nevers, E, Bouadma, L, Bouchaud, O, Bouchez, S, Bouhmani, D, Bouhour, D, Bouiller, K, Bouillet, L, Bouisse, C, Boureau, A, Bourke, J, Bouscambert, M, Bousquet, A, Bouziotis, J, Boxma, B, Boyer-Besseyre, M, Boylan, M, Braconnier, A, Braga, C, Brandenburger, T, Bras Monteiro, F, Brazzi, L, Breen, P, Breen, D, Brickell, K, Browne, S, Browne, A, Brozzi, N, Brusse-Keizer, M, Buchtele, N, Buesaquillo, C, Bugaeva, P, Buisson, M, Buonsenso, D, Burhan, E, Bustos, I, Butnaru, D, Cabie, A, Cabral, S, Caceres, E, Cadoz, C, Callahan, M, Calligy, K, Calvache, J, Camoes, J, Campana, V, Campbell, P, Campisi, J, Canepa, C, Cantero, M, Caraux-Paz, P, Carcel, S, Cardellino, C, Cardoso, S, Cardoso, F, Cardoso, N, Carelli, S, Carlier, N, Carmoi, T, Carney, G, Carqueja, I, Carret, M, Carrier, F, Carroll, I, Casanova, M, Cascao, M, Casey, S, Casimiro, J, Cassandra, B, Castaneda, S, Castanheira, N, Castor-Alexandre, G, Castrillon, H, Castro, I, Catarino, A, Catherine, F, Cattaneo, P, Cavalin, R, Cavalli, G, Cavayas, A, Ceccato, A, Cervantes-Gonzalez, M, Chair, A, Chakveatze, C, Chan, A, Chand, M, Chantalat Auger, C, Chapplain, J, Chas, J, Chatterjee, A, Chaudry, M, Chavez Iniguez, J, Chen, A, Chen, Y, Cheng, M, Cheret, A, Chiarabini, T, Chica, J, Chidambaram, S, Chin Tho, L, Chirouze, C, Chiumello, D, Cho, S, Cholley, B, Chopin, M, Chow, T, Chow, Y, Chua, H, Chua, J, Cidade, J, Cisneros Herreros, J, Ciullo, A, Clarke, J, Clarke, E, Granado, R, Clohisey, S, Cobb, P, Codan, C, Cody, C, Coelho, A, Coles, M, Colin, G, Collins, M, Colombo, S, Combs, P, Connor, M, Conrad, A, Contreras, S, Conway, E, Cooke, G, Copland, M, Cordel, H, Corley, A, Cornelis, S, Cornet, A, Corpuz, A, Cortegiani, A, Corvaisier, G, Costigan, E, Couffignal, C, Couffin-Cadiergues, S, Courtois, R, Cousse, S, Cregan, R, Crepy D'Orleans, C, Cristella, C, Croonen, S, Crowl, G, Crump, J, Cruz, C, Cruz Berm, J, Cruz Rojo, J, Csete, M, Cullen, A, Cummings, M, Curley, G, Curlier, E, Curran, C, Custodio, P, da Silva Filipe, A, Da Silveira, C, Dabaliz, A, Dahly, D, Dalton, H, Dalton, J, Daly, S, Daneman, N, Daniel, C, Dantas, J, D'Aragon, F, de Jong, M, de Loughry, G, de Mendoza, D, De Montmollin, E, de Oliveira Franca, R, de Pinho Oliveira, A, De Rosa, R, De Rose, C, de Silva, T, de Vries, P, Deacon, J, Dean, D, Debard, A, Debray, M, Decastro, N, Dechert, W, Deconninck, L, Decours, R, Defous, E, Delacroix, I, Delaveuve, E, Delavigne, K, Delfos, N, Deligiannis, I, Dell'Amore, A, Delmas, C, Delobel, P, Delsing, C, Demonchy, E, Denis, E, Deplanque, D, Depuydt, P, Desai, M, Descamps, D, Desvallees, M, Dewayanti, S, Dhanger, P, Diallo, A, Diamantis, S, Dias, A, Diaz, J, Diaz, P, Diaz, R, Didier, K, Diehl, J, Dieperink, W, Dimet, J, Dinot, V, Diop, F, Diouf, A, Dishon, Y, Djossou, F, Docherty, A, Doherty, H, Dondorp, A, Dong, A, Donnelly, M, Donohue, S, Donohue, Y, Donohue, C, Doran, P, Dorival, C, D'Ortenzio, E, Douglas, J, Douma, R, Dournon, N, Downer, T, Downey, J, Downing, M, Drake, T, Driscoll, A, Dryden, M, Duarte Fonseca, C, Dubee, V, Dubos, F, Ducancelle, A, Duculan, T, Dudman, S, Duggal, A, Dunand, P, Duplaix, M, Durante-Mangoni, E, Durham, L, Dussol, B, Duthoit, J, Duval, X, Dyrhol-Riise, A, Ean, S, Echeverria-Villalobos, M, Egan, S, Eira, C, El Sanharawi, M, Elapavaluru, S, Elharrar, B, Ellerbroek, J, Eloy, P, Elshazly, T, Elyazar, I, Enderle, I, Endo, T, Eng, C, Engelmann, I, Enouf, V, Epaulard, O, Esperatti, M, Esperou, H, Esposito-Farese, M, Estevao, J, Etienne, M, Ettalhaoui, N, Everding, A, Evers, M, Fabre, M, Fabre, I, Faheem, A, Fahy, A, Fairfield, C, Fakar, Z, Fareed, K, Faria, P, Farooq, A, Fateena, H, Fatoni, A, Faure, K, Favory, R, Fayed, M, Feely, N, Feeney, L, Fernandes, J, Fernandes, M, Fernandes, S, Ferrand, F, Devouge, E, Ferrao, J, Ferraz, M, Ferreira, S, Ferreira, I, Ferreira, B, Ferrer-Roca, R, Ferriere, N, Ficko, C, Figueiredo-Mello, C, Finlayson, W, Fiorda, J, Flament, T, Flateau, C, Fletcher, T, Florio, L, Flynn, D, Foley, C, Foley, J, Fomin, V, Fonseca, T, Fontela, P, Forsyth, S, Foster, D, Foti, G, Fourn, E, Fowler, R, Fraher, M, Franch-Llasat, D, Fraser, J, Fraser, C, Freire, M, Freitas Ribeiro, A, Friedrich, C, Fritz, R, Fry, S, Fuentes, N, Fukuda, M, Argin, G, Gaborieau, V, Gaci, R, Gagliardi, M, Gagnard, J, Gagneux-Brunon, A, Gaiao, S, Skeie, L, Gallagher, P, Gamble, C, Gani, Y, Garan, A, Garcia, R, Garcia-Diaz, J, Garcia-Gallo, E, Garimella, N, Garot, D, Garrait, V, Gauli, B, Gault, N, Gavin, A, Gavrylov, A, Gaymard, A, Gebauer, J, Geraud, E, Morlaes, L, Germano, N, Ghisulal, P, Ghosn, J, Giani, M, Gibson, J, Gigante, T, Gilg, M, Gilroy, E, Giordano, G, Girvan, M, Gissot, V, Glikman, D, Glybochko, P, Gnall, E, Goco, G, Goehringer, F, Goepel, S, Goh, J, Golob, J, Gomes, R, Gomez, K, Gomez-Junyent, J, Gominet, M, Gonzalez, A, Gordon, P, Gorenne, I, Goubert, L, Goujard, C, Goulenok, T, Grable, M, Graf, J, Grandin, E, Granier, P, Grasselli, G, Green, C, Greene, C, Greenhalf, W, Greffe, S, Grieco, D, Griffee, M, Griffiths, F, Grigoras, I, Groenendijk, A, Grosse Lordemann, A, Gruner, H, Gu, Y, Guedj, J, Guego, M, Guellec, D, Guerguerian, A, Guerreiro, D, Guery, R, Guillaumot, A, Guilleminault, L, Guimaraes de Castro, M, Guimard, T, Haalboom, M, Haber, D, Habraken, H, Hachemi, A, Hackmann, A, Hadri, N, Haidri, F, Hakak, S, Hall, A, Halpin, S, Hameed, J, Hamer, A, Hamers, R, Hamidfar, R, Hammond, T, Han, L, Haniffa, R, Hao, K, Hardwick, H, Harrison, E, Harrison, J, Harrison, S, Hartman, A, Hasan, M, Hashmi, J, Hayat, M, Hayes, A, Hays, L, Heerman, J, Heggelund, L, Hendry, R, Hennessy, M, Henriquez-Trujillo, A, Hentzien, M, Hernandez-Montfort, J, Hershey, A, Hesstvedt, L, Hidayah, A, Higgins, E, Higgins, D, Higgins, R, Hinchion, R, Hinton, S, Hiraiwa, H, Hirkani, H, Hitoto, H, Ho, Y, Hoctin, A, Hoffmann, I, Hoh, W, Hoiting, O, Holt, R, Holter, J, Horcajada, J, Hoshino, K, Houas, I, Hough, C, Houltham, S, Hsu, J, Hulot, J, Huo, S, Hurd, A, Hussain, I, Ijaz, S, Illes, H, Imbert, P, Imran, M, Sikander, R, Imtiaz, A, Inacio, H, Infante Dominguez, C, Ing, Y, Iosifidis, E, Ippolito, M, Isgett, S, Isidoro, T, Ismail, N, Isnard, M, Itai, J, Ivulich, D, Jaafar, D, Jaafoura, S, Jabot, J, Jackson, C, Jamieson, N, Janes, V, Jaquet, P, Jaud-Fischer, C, Jaureguiberry, S, Javidfar, J, Jaworsky, D, Jego, F, Jelani, A, Jenum, S, Jimbo-Sotomayor, R, Joe, O, Jorge Garcia, R, Joseph, C, Joseph, M, Joshi, S, Jourdain, M, Jouvet, P, Jung, H, Jung, A, Juzar, D, Kafif, O, Kaguelidou, F, Kaisbain, N, Kaleesvran, T, Kali, S, Kalicinska, A, Kalomoiri, S, Kamaluddin, M, Kamaruddin, Z, Kamarudin, N, Kambiya, P, Kamineni, K, Kandamby, D, Kandel, C, Kang, K, Kanwal, D, Karpayah, P, Karsies, T, Kasugai, D, Kataria, A, Katz, K, Kaur, A, Kay, C, Keane, H, Keating, S, Kedia, P, Kelly, C, Kelly, Y, Kelly, A, Kelly, N, Kelly, S, Kelsey, M, Kennedy, R, Kennon, K, Kernan, M, Kerroumi, Y, Keshav, S, Khalid, I, Khalid, O, Khalil, A, Khan, C, Khan, I, Khan, Q, Khanal, S, Khatak, A, Khawaja, A, Kherajani, K, Kho, M, Khoo, S, Khoo, R, Khoo, D, Khoso, N, Kiat, K, Kida, Y, Kiiza, P, Granerud, B, Kildal, A, Kim, J, Kimmoun, A, Kindgen-Milles, D, King, A, Kitamura, N, Klenerman, P, Klont, R, Bekken, G, Knight, S, Kobbe, R, Kodippily, C, Kohns Vasconcelos, M, Koirala, S, Komatsu, M, Kosgei, C, Kpangon, A, Krawczyk, K, Krishnan, V, Krishnan, S, Kruglova, O, Kumar, D, Kumar, G, Kumar, M, Kuriakose, D, Kurtzman, E, Kutsogiannis, D, Kutsyna, G, Kyriakoulis, K, Lachatre, M, Lacoste, M, Laffey, J, Lagrange, M, Laine, F, Lairez, O, Lakhey, S, Lalueza, A, Lambert, M, Lamontagne, F, Langelot-Richard, M, Langlois, V, Lantang, E, Lanza, M, Laribi, S, Lariviere, D, Lasry, S, Lath, S, Latif, N, Launay, O, Laureillard, D, Lavie-Badie, Y, Law, A, Lawrence, T, Lawrence, C, Le, M, Le Bihan, C, Le Bris, C, Le Falher, G, Le Fevre, L, Le Hingrat, Q, Le Marechal, M, Mestre, S, Le Moal, G, Le Moing, V, Le Nagard, H, Le Turnier, P, Leal, E, Leal Santos, M, Lee, T, Lee, J, Lee, H, Lee, B, Lee, Y, Lee, S, Leeming, G, Lefebvre, L, Lefebvre, B, Lefevre, B, Legac, S, Lelievre, J, Lellouche, F, Lemaignen, A, Lemee, V, Lemeur, A, Lemmink, G, Lene, H, Lennon, J, Leon, R, Leone, M, Lepiller, Q, Lescure, F, Lesens, O, Lesouhaitier, M, Lester-Grant, A, Levy, B, Levy, Y, Levy-Marchal, C, Lewandowska, K, L'Her, E, Li Bassi, G, Liang, J, Liaquat, A, Liegeon, G, Lim, W, Lim, K, Lima, C, Lina, L, Lina, B, Lind, A, Lingad, M, Lingas, G, Lion-Daolio, S, Liu, K, Livrozet, M, Lizotte, P, Loforte, A, Lolong, N, Loon, L, Lopes, D, Lopez-Colon, D, Lopez-Revilla, J, Loschner, A, Loubet, P, Loufti, B, Louis, G, Lourenco, S, Lovelace-Macon, L, Low, L, Lowik, M, Loy, J, Lucet, J, Lumbreras Bermejo, C, Luna, C, Lungu, O, Luong, L, Luque, N, Luton, D, Lwin, N, Lyons, R, Maasikas, O, Mabiala, O, Machado, M, Macheda, G, Madiha, H, Maestro De La Calle, G, Mahieu, R, Mahy, S, Maia, A, Maier, L, Maillet, M, Maitre, T, Malfertheiner, M, Malik, N, Mallon, P, Maltez, F, Malvy, D, Manda, V, Mandelbrot, L, Manetta, F, Mankikian, J, Manning, E, Manuel, A, Malaque, C, Marino, F, Marino, D, Markowicz, S, Maroun Eid, C, Marques, A, Marquis, C, Marsh, B, Marsh, L, Marshal, M, Marshall, J, Martelli, C, Martin, D, Martin, E, Martin-Blondel, G, Martinot, M, Martin-Quiros, A, Martins, J, Martins, A, Martins, N, Martins Rego, C, Martucci, G, Martynenko, O, Marwali, E, Marzukie, M, Maslove, D, Mason, S, Masood, S, Mat Nor, B, Matan, M, Mathew, M, Mathieu, D, Mattei, M, Matulevics, R, Maulin, L, Maxwell, M, Maynar, J, Mazzoni, T, Mcevoy, N, Mcsweeney, L, Mcarthur, C, Mccarthy, A, Mccloskey, C, Mcconnochie, R, Mcdermott, S, Mcdonald, S, Mcelroy, A, Mcelwee, S, Mceneany, V, Mcgeer, A, Mckay, C, Mckeown, J, Mclean, K, Mcnally, P, Mcnicholas, B, Mcpartlan, E, Meaney, E, Mear-Passard, C, Mechlin, M, Meher, M, Mehkri, O, Mele, F, Melo, L, Memon, K, Mendes, J, Menkiti, O, Menon, K, Mentzer, A, Mercier, E, Mercier, N, Merckx, A, Mergeay-Fabre, M, Mergler, B, Mesquita, A, Meta, R, Metwally, O, Meybeck, A, Meyer, D, Meynert, A, Meysonnier, V, Meziane, A, Mezidi, M, Michelanglei, C, Michelet, I, Mihelis, E, Mihnovit, V, Miranda-Maldonado, H, Misnan, N, Mohamed, T, Mohamed, N, Moin, A, Molina, D, Molinos, E, Molloy, B, Mone, M, Monteiro, A, Montes, C, Montrucchio, G, Moore, S, Morales Cely, L, Moro, L, Motherway, C, Motos, A, Mouquet, H, Mouton Perrot, C, Moyet, J, Mudara, C, Mufti, A, Muh, N, Muhamad, D, Mullaert, J, Muller, F, Muller, K, Muneeb, S, Munir, N, Munshi, L, Murphy, A, Murphy, L, Murris, M, Murthy, S, Musaab, H, Muvindi, H, Muyandy, G, Myrodia, D, Mohd-Hanafiah, F, Nagpal, D, Nagrebetsky, A, Narasimhan, M, Narayanan, N, Nasim Khan, R, Nazerali-Maitland, A, Neant, N, Neb, H, Nelwan, E, Neto, R, Neumann, E, Ng, P, Ng, W, Nghi, A, Nguyen, D, Ni Choileain, O, Ni Leathlobhair, N, Nitayavardhana, P, Nonas, S, Noordin, N, Noret, M, Norharizam, N, Norman, L, Notari, A, Noursadeghi, M, Nowicka, K, Nowinski, A, Nseir, S, Nunez, J, Nurnaningsih, N, Nusantara, D, Nyamankolly, E, Brien, F, Callaghan, A, O'Callaghan, A, Occhipinti, G, Oconnor, D, O'Donnell, M, Ogston, T, Ogura, T, Oh, T, O'Halloran, S, O'Hearn, K, Ohshimo, S, Oldakowska, A, Oliveira, J, Oliveira, L, Ong, J, Oosthuyzen, W, Opavsky, A, Openshaw, P, Orakzai, S, Orozco-Chamorro, C, Ortoleva, J, Osatnik, J, O'Shea, L, O'Sullivan, M, Othman, S, Ouamara, N, Ouissa, R, Oziol, E, Pagadoy, M, Pages, J, Palacios, M, Palacios, A, Palmarini, M, Panarello, G, Paneru, H, Pang, L, Panigada, M, Pansu, N, Papadopoulos, A, Parke, R, Parker, M, Parra, B, Pasha, T, Pasquier, J, Pastene, B, Patauner, F, Patel, D, Pathmanathan, M, Patrao, L, Patricio, P, Patrier, J, Patterson, L, Pattnaik, R, Paul, M, Paul, C, Paulos, J, Paxton, W, Payen, J, Peariasamy, K, Peek, G, Peelman, F, Peiffer-Smadja, N, Peigne, V, Pejkovska, M, Pelosi, P, Peltan, I, Pereira, R, Perez, D, Periel, L, Perpoint, T, Pesenti, A, Pestre, V, Petrou, L, Petrov-Sanchez, V, Pettersen, F, Peytavin, G, Pharand, S, Piagnerelli, M, Picard, W, Picone, O, de Piero, M, Pierobon, C, Piersma, D, Pimentel, C, Pinto, R, Pires, C, Pironneau, I, Piroth, L, Pitaloka, A, Pius, R, Plantier, L, Png, H, Poissy, J, Pokeerbux, R, Pokorska-Spiewak, M, Poli, S, Pollakis, G, Ponscarme, D, Popielska, J, Porto, D, Post, A, Postma, D, Povoa, P, Povoas, D, Powis, J, Prapa, S, Preau, S, Prebensen, C, Preiser, J, Prinssen, A, Priyadarshani, G, Proenca, L, Pudota, S, Puechal, O, Semedi, B, Pulicken, M, Purcell, G, Quesada, L, Quinones-Cardona, V, Quiros 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J., Diaz P., Diaz R., Didier K., Diehl J. -L., Dieperink W., Dimet J., Dinot V., Diop F., Diouf A., Dishon Y., Djossou F., Docherty A. B., Doherty H., Dondorp A. M., Dong A., Donnelly M., Donohue S., Donohue Y., Donohue C., Doran P., Dorival C., D'Ortenzio E., Douglas J. J., Douma R., Dournon N., Downer T., Downey J., Downing M., Drake T., Driscoll A., Dryden M., Duarte Fonseca C., Dubee V., Dubos F., Ducancelle A., Duculan T., Dudman S., Duggal A., Dunand P., Duplaix M., Durante-Mangoni E., Durham L., Dussol B., Duthoit J., Duval X., Dyrhol-Riise A. M., Ean S. C., Echeverria-Villalobos M., Egan S., Eira C., El Sanharawi M., Elapavaluru S., Elharrar B., Ellerbroek J., Eloy P., Elshazly T., Elyazar I., Enderle I., Endo T., Eng C. C., Engelmann I., Enouf V., Epaulard O., Esperatti M., Esperou H., Esposito-Farese M., Estevao J., Etienne M., Ettalhaoui N., Everding A. G., Evers M., Fabre M., Fabre I., Faheem A., Fahy A., Fairfield C. 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G., Germano N., Ghisulal P. K., Ghosn J., Giani M., Gibson J., Gigante T., Gilg M., Gilroy E., Giordano G., Girvan M., Gissot V., Glikman D., Glybochko P., Gnall E., Goco G., Goehringer F., Goepel S., Goh J. Y., Golob J., Gomes R., Gomez K., Gomez-Junyent J., Gominet M., Gonzalez A., Gordon P., Gorenne I., Goubert L., Goujard C., Goulenok T., Grable M., Graf J., Grandin E. W., Granier P., Grasselli G., Green C. A., Greene C., Greenhalf W., Greffe S., Grieco D. L., Griffee M., Griffiths F., Grigoras I., Groenendijk A., Grosse Lordemann A., Gruner H., Gu Y., Guedj J., Guego M., Guellec D., Guerguerian A. -M., Guerreiro D., Guery R., Guillaumot A., Guilleminault L., Guimaraes de Castro M., Guimard T., Haalboom M., Haber D., Habraken H., Hachemi A., Hackmann A., Hadri N., Haidri F., Hakak S., Hall A., Halpin S., Hameed J., Hamer A., Hamers R. L., Hamidfar R., Hammond T., Han L. Y., Haniffa R., Hao K. W., Hardwick H., Harrison E. M., Harrison J., Harrison S. B. E., Hartman A., Hasan M. 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R., Kobbe R., Kodippily C., Kohns Vasconcelos M., Koirala S., Komatsu M., Kosgei C., Kpangon A., Krawczyk K., Krishnan V., Krishnan S., Kruglova O., Kumar D., Kumar G., Kumar M., Kuriakose D., Kurtzman E., Kutsogiannis D., Kutsyna G., Kyriakoulis K., Lachatre M., Lacoste M., Laffey J. G., Lagrange M., Laine F., Lairez O., Lakhey S., Lalueza A., Lambert M., Lamontagne F., Langelot-Richard M., Langlois V., Lantang E. Y., Lanza M., Laribi S., Lariviere D., Lasry S., Lath S., Latif N., Launay O., Laureillard D., Lavie-Badie Y., Law A., Lawrence T., Lawrence C., Le M., Le Bihan C., Le Bris C., Le Falher G., Le Fevre L., Le Hingrat Q., Le Marechal M., Mestre S., Le Moal G., Le Moing V., Le Nagard H., Le Turnier P., Leal E., Leal Santos M., Lee T. C., Lee J., Lee H. G., Lee B. H., Lee Y. L., Lee S. H., Leeming G., Lefebvre L., Lefebvre B., Lefevre B., LeGac S., Lelievre J. -D., Lellouche F., Lemaignen A., Lemee V., Lemeur A., Lemmink G., Lene H. S., Lennon J., Leon R., Leone M., Lepiller Q., Lescure F. -X., Lesens O., Lesouhaitier M., Lester-Grant A., Levy B., Levy Y., Levy-Marchal C., Lewandowska K., L'Her E., Li Bassi G., Liang J., Liaquat A., Liegeon G., Lim W. S., Lim K. C., Lima C., Lina L., Lina B., Lind A., Lingad M. K., Lingas G., Lion-Daolio S., Liu K., Livrozet M., Lizotte P., Loforte A., Lolong N., Loon L. C., Lopes D., Lopez-Colon D., Lopez-Revilla J. W., Loschner A. L., Loubet P., Loufti B., Louis G., Lourenco S., Lovelace-Macon L., Low L. L., Lowik M., Loy J. S., Lucet J. C., Lumbreras Bermejo C., Luna C. M., Lungu O., Luong L., Luque N., Luton D., Lwin N., Lyons R., Maasikas O., Mabiala O., Machado M., Macheda G., Madiha H., Maestro De La Calle G., Mahieu R., Mahy S., Maia A. R., Maier L. S., Maillet M., Maitre T., Malfertheiner M., Malik N., Mallon P., Maltez F., Malvy D., Manda V., Mandelbrot L., Manetta F., Mankikian J., Manning E., Manuel A., Malaque C. M. S., Marino F., Marino D., Markowicz S., Maroun Eid C., Marques A., Marquis C., Marsh B., Marsh L., Marshal M., Marshall J., Martelli C. T., Martin D. -A., Martin E., Martin-Blondel G., Martinot M., Martin-Quiros A., Martins J., Martins A., Martins N., Martins Rego C., Martucci G., Martynenko O., Marwali E. M., Marzukie M., Maslove D., Mason S., Masood S., Mat Nor B., Matan M., Mathew M., Mathieu D., Mattei M., Matulevics R., Maulin L., Maxwell M., Maynar J., Mazzoni T., McEvoy N., McSweeney L., McArthur C., McCarthy A., McCloskey C., McConnochie R., McDermott S., McDonald S. E., McElroy A., McElwee S., McEneany V., McGeer A., McKay C., McKeown J., McLean K. A., McNally P., McNicholas B., McPartlan E., Meaney E., Mear-Passard C., Mechlin M., Meher M., Mehkri O., Mele F., Melo L., Memon K., Mendes J. J., Menkiti O., Menon K., Mentzer A. J., Mercier E., Mercier N., Merckx A., Mergeay-Fabre M., Mergler B., Mesquita A., Meta R., Metwally O., Meybeck A., Meyer D., Meynert A. M., Meysonnier V., Meziane A., Mezidi M., Michelanglei C., Michelet I., Mihelis E., Mihnovit V., Miranda-Maldonado H., Misnan N. A., Mohamed T. J., Mohamed N. N. E., Moin A., Molina D., Molinos E., Molloy B., Mone M., Monteiro A., Montes C., Montrucchio G., Moore S. C., Moore S., Morales Cely L., Moro L., Motherway C., Motos A., Mouquet H., Mouton Perrot C., Moyet J., Mudara C., Mufti A. K., Muh N. Y., Muhamad D., Mullaert J., Muller F., Muller K. E., Muneeb S., Munir N., Munshi L., Murphy A., Murphy L., Murris M., Murthy S., Musaab H., Muvindi H., Muyandy G., Myrodia D. M., Mohd-Hanafiah F. N., Nagpal D., Nagrebetsky A., Narasimhan M., Narayanan N., Nasim Khan R., Nazerali-Maitland A., Neant N., Neb H., Nelwan E., Neto R., Neumann E., Ng P., Ng W. Y., Nghi A., Nguyen D., Ni Choileain O., Ni Leathlobhair N., Nitayavardhana P., Nonas S., Noordin N. A. M., Noret M., Norharizam N. F. I., Norman L., Notari A., Noursadeghi M., Nowicka K., Nowinski A., Nseir S., Nunez J. I., Nurnaningsih N., Nusantara D. U., Nyamankolly E., Brien F. O., Callaghan A. O., O'Callaghan A., Occhipinti G., OConnor D., O'Donnell M., Ogston T., Ogura T., Oh T. -H., O'Halloran S., O'Hearn K., Ohshimo S., Oldakowska A., Oliveira J., Oliveira L., Ong J. Y., Oosthuyzen W., Opavsky A., Openshaw P., Orakzai S., Orozco-Chamorro C. M., Ortoleva J., Osatnik J., O'Shea L., O'Sullivan M., Othman S. Z., Ouamara N., Ouissa R., Oziol E., Pagadoy M., Pages J., Palacios M., Palacios A., Palmarini M., Panarello G., Paneru H., Pang L. H., Panigada M., Pansu N., Papadopoulos A., Parke R., Parker M., Parra B., Pasha T., Pasquier J., Pastene B., Patauner F., Patel D., Pathmanathan M. D., Patrao L., Patricio P., Patrier J., Patterson L., Pattnaik R., Paul M., Paul C., Paulos J., Paxton W. A., Payen J. -F., Peariasamy K., Peek G. J., Peelman F., Peiffer-Smadja N., Peigne V., Pejkovska M., Pelosi P., Peltan I. D., Pereira R., Perez D., Periel L., Perpoint T., Pesenti A., Pestre V., Petrou L., Petrov-Sanchez V., Pettersen F. O., Peytavin G., Pharand S., Piagnerelli M., Picard W., Picone O., de Piero M., Pierobon C., Piersma D., Pimentel C., Pinto R., Pires C., Pironneau I., Piroth L., Pitaloka A., Pius R., Plantier L., Png H. S., Poissy J., Pokeerbux R., Pokorska-Spiewak M., Poli S., Pollakis G., Ponscarme D., Popielska J., Porto D. B., Post A. -M., Postma D. F., Povoa P., Povoas D., Powis J., Prapa S., Preau S., Prebensen C., Preiser J. -C., Prinssen A., Priyadarshani G. D. D., Proenca L., Pudota S., Puechal O., Semedi B. P., Pulicken M., Purcell G., Quesada L., Quinones-Cardona V., Quiros Gonzalez V., Quist-Paulsen E., Quraishi M., Rabaa M., Rabaud C., Rabindrarajan E., Rafael A., Rafiq M., Ragazzo G., Rahardjani M., Rahman R. A., Rahman A. K. H. A., Rahutullah A., Rainieri F., Rajahram G. S., Ramachandran P., Ramli A. A., Rammaert B., Rana A., Rangappa R., Ranjan R., Rapp C., Rashan A., Rashan T., Rasheed G., Rasmin M., Ratsep I., Rau C., Ravi T., Raza A., Real A., Rebaudet S., Redl S., Reeve B., Rehman A., Reid L., Reikvam D. H., Reis R., Rello J., Remppis J., Remy M., Ren H., Renk H., Resseguier A. -S., Revest M., Rewa O., Reyes L. F., Reyes T., Ribeiro M. I., Ricchiuto A., Richardson D., Richier L., Ridzuan S. N. A. A., Riera J., Rios A. L., Rishu A., Rispal P., Risso K., Nunez M. A. R., Rizer N., Robba C., Roberto A., Roberts S., Robertson D. L., Robineau O., Roche-Campo F., Rodari P., Rodeia S., Roessler B., Roger P. -M., Roilides E., Romaru J., Roncon-Albuquerque R., Roriz M., Rosa-Calatrava M., Rose M., Rosenberger D., Roslan N. H. M., Rossanese A., Rossetti M., Rossignol B., Rossignol P., Rousset S., Roy C., Roze B., Rusmawatiningtyas D., Russell C. D., Ryan M., Ryckaert S., Holten A. R., Saba I., Sadaf S., Sadat M., Sahraei V., Saint-Gilles M., Sakiyalak P., Salahuddin N., Salazar L., Saleem J., Sales G., Sallaberry S., Salmon Gandonniere C., Salvator H., Sanchez O., Sanchez-Miralles A., Sancho-Shimizu V., Sandhu G., Sandhu Z., Sandrine P. -F., Santos M., Sarfo-Mensah S., Sarmento Banheiro B., Sarmiento I. C. E., Sarton B., Satya A., Satyapriya S., Satyawati R., Saviciute E., Savvidou P., Saw Y. T., Schaffer J., Schermer T., Scherpereel A., Schneider M., Schroll S., Schwameis M., Schwartz G., Scicluna B., Scott J. T., Scott-Brown J., Sedillot N., Seitz T., Selvanayagam J., Selvarajoo M., Semaille C., Senian R. B., Senneville E., Sepulveda C., Sequeira F., Sequeira T., Serpa Neto A., Serrano Balazote P., Shadowitz E., Shahidan S. A., Shamsah M., Shankar A., Sharjeel S., Shaw C. A., Shaw V., Sheharyar A., Shetty R., Shetty R. M., Shi H., Shiban N., Shiekh M., Shime N., Shimizu H., Shimizu K., Shrapnel S., Shrestha P. S., Shrestha S. K., Shum H. P., Si Mohammed N., Siang N. Y., Sibiude J., Siddiqui A., Sillaots P., Silva C., Silva R., Silva M. J., Sin W. C., Sinatti D., Singh P., Singh B. C., Sitompul P. A., Sivam K., Skogen V., Smith S., Smood B., Smyth C., Smyth M., Snacken M., So D., Soh T. V., Solomon J., Solomon T., Sommet A., Song R., Song T., Song Chia J., Sonntagbauer M., Soom A. M., Sotto A., Soum E., Sousa M., Sousa A. C., Sousa Uva M., Souza-Dantas V., Sperry A., Spinuzza E., Sanka Ruwan Sri Darshana B. P., Sriskandan S., Stabler S., Staudinger T., Stecher S. -S., Steinsvik T., Stienstra Y., Stiksrud B., Stolz E., Stone A., Stuart D., Stuart A., Subekti D., Suen G., Suen J. Y., Sultana A., Summers C., Supic D., Suppiah D., Surovcova M., Suwarti S., Svistunov A., Syahrin S., Syrigos K., Sztajnbok J., Szuldrzynski K., Tabrizi S., Tagherset L., Taib S. M., Talarek E., Taleb S., Talsma J., Tamisier R., Tampubolon M. L., Tan K. K., Tan Y. C., Tanaka T., Tanaka H., Taniguchi H., Taqdees H., Taqi A., Tardivon C., Tattevin P., Taufik M. A., Tawfik H., Tedder R. S., Tee T. Y., Teixeira J., Tejada S., Tellier M. -C., Teoh S. K., Teotonio V., Teoule F., Terpstra P., Terrier O., Terzi N., Tessier-Grenier H., Tey A., Thabit A. A. M., Thakur A., Tham Z. D., Thangavelu S., Thibault V., Thiberville S. -D., Thill B., Thirumanickam J., Thompson S., Thomson E. C., Thomson D., Thurai S. R. T., Thwaites R. S., Tierney P., Tieroshyn V., Timashev P. S., Timsit J. -F., Tissot N., Toh J. Z. Y., Toki M., Tonby K., Tonnii S. L., Torres M., Torres A., Torres Santos-Olmo R. M., Torres-Zevallos H., Towers M., Trapani T., Treoux T., Tromeur C., Trontzas I., Trouillon T., Truong J., Tual C., Tubiana S., Tuite H., Turmel J. -M., Turtle L. C. W., Tveita A., Twardowski P., Uchiyama M., Udayanga P. G. I., Udy A., Ullrich R., Uribe A., Usman A., Uyeki T. 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M., Yamazaki M., Yazdanpanah Y., Yee Liang Hing N., Yelnik C., Yeoh C. H., Yerkovich S., Yokoyama T., Yonis H., Yousif O., Yuliarto S., Zaaqoq A., Zabbe M., Zacharowski K., Zahid M., Zahran M., Zaidan N. Z. B., Zambon M., Zambrano M., Zanella A., Zawadka K., Zaynah N., Zayyad H., Zoufaly A., and Zucman D.
- Abstract
Background: We describe demographic features, treatments and clinical outcomes in the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) COVID-19 cohort, one of the world’s largest international, standardized data sets concerning hospitalized patients. Methods: The data set analysed includes COVID-19 patients hospitalized between January 2020 and January 2022 in 52 countries. We investigated how symptoms on admission, co-morbidities, risk factors and treatments varied by age, sex and other characteristics. We used Cox regression models to investigate associations between demographics, symptoms, co-morbidities and other factors with risk of death, admission to an intensive care unit (ICU) and invasive mechanical ventilation (IMV). Results: Data were available for 689 572 patients with laboratory-confirmed (91.1%) or clinically diagnosed (8.9%) SARS-CoV-2 infection from 52 countries. Age [adjusted hazard ratio per 10 years 1.49 (95% CI 1.48, 1.49)] and male sex [1.23 (1.21, 1.24)] were associated with a higher risk of death. Rates of admission to an ICU and use of IMV increased with age up to age 60 years then dropped. Symptoms, co-morbidities and treatments varied by age and had varied associations with clinical outcomes. The case-fatality ratio varied by country partly due to differences in the clinical characteristics of recruited patients and was on average 21.5%. Conclusions: Age was the strongest determinant of risk of death, with a ~30-fold difference between the oldest and youngest groups; each of the co-morbidities included was associated with up to an almost 2-fold increase in risk. Smoking and obesity were also associated with a higher risk of death. The size of our international database and the standardized data collection method make this study a comprehensive international description of COVID-19 clinical features. Our findings may inform strategies that involve prioritization of patients hospitalized with COVID-19 who hav
- Published
- 2023
3. Thrombotic and hemorrhagic complications of COVID-19 in adults hospitalized in high-income countries compared with those in adults hospitalized in low- and middle-income countries in an international registry
- Author
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Y., Muhamad D., Mullaert J., Muller F., Muller K. E., Murphy A., Murphy L., Murray P., Murris M., Murthy S., Musaab H., Muyandy G., Myrodia D. M., Nagpal D., Nagrebetsky A., Narasimhan M., Narayanan N., Nazerali-Maitland A., Neant N., Neb H., Neto R., Neumann E., Ng P. Y., Ng W. Y., Nghi A., Nguyen D., Choileain O. N., Leathlobhair N. N., Nichol A. D., Nitayavardhana P., Nonas S., Mohd Noordin N. A., Noret M., Izzati Norharizam N. F., Norman L., Noursadeghi M., Nowinski A., Nseir S., Nunez J. I., Nyamankolly E., Brien F. O., Callaghan A. O., O'Callaghan A., Occhipinti G., OConnor D., O'Donnell M., Ogston T., Ogura T., Oh T. -H., O'Halloran S., O'Hearn K., Ohshimo S., Oliveira J., Oliveira L., Olliaro P. L., Ong D. S. Y., Ong J. Y., Oosthuyzen W., Opavsky A., Openshaw P., Orozco-Chamorro C. M., Ortoleva J., Osatnik J., O'Shea L., O'Sullivan M., Othman S. Z., Ouamara N., Ouissa R., Oziol E., Pagadoy M., Pages J., Palacios A., Palmarini M., Panarello G., Panda P. K., Pang L. H., Panigada M., Pansu N., Papadopoulos A., Parke R., Pasquier J., Pastene B., Patauner F., Pathmanathan M. D., Patrao L., Patricio P., Patrier J., Patterson L., Paul C., Paul M., Paulos J., Paxton W. A., Payen J. -F., Peake S. L., Peariasamy K., Jimenez M. P., Peek G. J., Peelman F., Peiffer-Smadja N., Peigne V., Pejkovska M., Pelosi P., Peltan I. D., Pereira R., Perez D., Periel L., Perpoint T., Pesenti A., Pestre V., Petrou L., Petrovic M., Petrov-Sanchez V., Pettersen F. O., Peytavin G., Pharand S., Picard W., Picone O., de Piero M., Pierobon C., Piersma D., Pimentel C., Pinto R., Piquard V., Pires C., Pironneau I., Piroth L., Piubelli C., Pius R., Plantier L., Png H. S., Poissy J., Pokeerbux R., Poli S., Pollakis G., Ponscarme D., Porto D. B., Post A. -M., Postma D. F., Povoa P., Povoas D., Powis J., Prapa S., Preau S., Prebensen C., Preiser J. -C., Prinssen A., Pritchard M. G., Proenca L., Pudota S., Puechal O., Semedi B. P., Purcell G., Quesada L., Gonzalez V. Q., Quist-Paulsen E., Quraishi M., Qutishat F., Rabaud C., Rafael A., Rafiq M., Rahman R. A., Haji Ab Rahman A. K., Rainieri F., Rajahram G. S., Ramakrishnan N., Ramalho J., Ramli A. A., Rammaert B., Ramos G. V., Ranjan R., Rapp C., Rasmin M., Ratsep I., Ravi T., Real A., Rebaudet S., Redl S., Reeve B., Reid L., Reikvam D. H., Reis R., Rello J., Remppis J., Remy M., Ren H., Renk H., Resseguier A. -S., Revest M., Rewa O., Reyes T., Ribeiro M. I., Richardson D., Richier L., Atikah Ahmad Ridzuan S. N., Rios A. L., Rishu A., Rispal P., Risso K., Rizer N., Robba C., Roberto A., Roberts S., Robertson D. L., Robineau O., Roche-Campo F., Rodari P., Rodeia S., Roessler B., Roger P. -M., Roger C., Roilides E., Rojek A., Romaru J., Roncon-Albuquerque R., Roriz M., Rosa-Calatrava M., Rose M., Rossanese A., Rossetti M., Rossignol B., Rossignol P., Rousset S., Roy C., Roze B., Russell C. D., Ryan M., Ryckaert S., Holten A. R., Saba I., Sadat M., Sahraei V., Saint-Gilles M., Sakiyalak P., Salazar L., Sales G., Sallaberry S., Gandonniere C. S., Salvator H., Sanchez O., Sanchez E., Sanchez-Miralles A., Sancho-Shimizu V., Sandhu G., Sandhu Z., Sandrine P. -F., Sandulescu O., Santos M., Sarfo-Mensah S., Sarmento Banheiro B., Sarmiento I. C. E., Sarton B., Satyapriya S., Satyawati R., Saviciute E., Savvidou P., Saw Y. T., Schaffer J., Schermer T., Scherpereel A., Schneider M., Schroll S., Schwameis M., Scicluna B., Scott J. T., Scott-Brown J., Sedillot N., Seitz T., Selvarajoo M., Semaille C., Semple M. G., Senian R. B., Senneville E., Sepulveda C., Sequeira F., Sequeira T., Neto A. S., Balazote P. S., Shadowitz E., Shahidan S. A., Shamsah M., Sharjeel S., Sharma P., Shaw C. A., Shaw V., Sheenan J. R., Shi H., Shime N., Shimizu K., Shrapnel S., Shum H. P., Mohammed N. S., Siang N. Y., Sibiude J., Siddiqui A., Sigfrid L., Sillaots P., Silva C., Silva R., Silva M. J., Lim Heng B. S., Sin W. C., Singh P., Singh B. C., Sitompul P. A., Sivam K., Skogen V., Smith S., Smood B., Smyth C., Smyth M., Snacken M., So D., Soh T. V., Solomon J., Solomon T., Somers E., Sommet A., Song R., Song M. J., Song T., Chia J. S., Sonntagbauer M., Soom A. M., Sotto A., Soum E., Sousa M., Sousa A. C., Uva M. S., Souza-Dantas V., Sperry A., Spinuzza E., Sriskandan S., Stabler S., Staudinger T., Stecher S. -S., Steinsvik T., Stienstra Y., Stiksrud B., Stolz E., Stone A., Streinu-Cercel A., Stuart A., Stuart D., Su R., Suen J. Y., Suen G., Sukumar P., Sultana A., Summers C., Supic D., Suppiah D., Surovcova M., Syahrin S., Syrigos K., Sztajnbok J., Szuldrzynski K., Tabrizi S., Taccone F. S., Tagherset L., Taib S. M., Taleb S., Talsma J., Tampubolon M. L., Tan K. K., Tan Y. C., Tanaka H., Tanaka T., Taniguchi H., Tardivon C., Tattevin P., Taufik M. A., Tawfik H., Tedder R. S., Tee T. Y., Teixeira J., Tejada S., Tellier M. -C., Teoh S. 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R., Yamazaki M., Yarad E., Yazdanpanah Y., Liang Hing N. Y., Yelnik C., Yeoh C. H., Yerkovich S., Yokoyama T., Yonis H., Yousif O., Zaaqoq A., Zabbe M., Zacharowski K., Zahid M., Zahran M., Binti Zaidan N. Z., Zambon M., Zambrano M., Zanella A., Zaynah N., Zayyad H., Zoufaly A., and Zucman D.
- Abstract
Background: COVID-19 has been associated with a broad range of thromboembolic, ischemic, and hemorrhagic complications (coagulopathy complications). Most studies have focused on patients with severe disease from high-income countries (HICs). Objectives: The main aims were to compare the frequency of coagulopathy complications in developing countries (low- and middle-income countries [LMICs]) with those in HICs, delineate the frequency across a range of treatment levels, and determine associations with in-hospital mortality. Methods: Adult patients enrolled in an observational, multinational registry, the International Severe Acute Respiratory and Emerging Infections COVID-19 study, between January 1, 2020, and September 15, 2021, met inclusion criteria, including admission to a hospital for laboratory-confirmed, acute COVID-19 and data on complications and survival. The advanced-treatment cohort received care, such as admission to the intensive care unit, mechanical ventilation, or inotropes or vasopressors; the basic-treatment cohort did not receive any of these interventions. Results: The study population included 495,682 patients from 52 countries, with 63% from LMICs and 85% in the basic treatment cohort. The frequency of coagulopathy complications was higher in HICs (0.76%-3.4%) than in LMICs (0.09%-1.22%). Complications were more frequent in the advanced-treatment cohort than in the basic-treatment cohort. Coagulopathy complications were associated with increased in-hospital mortality (odds ratio, 1.58; 95% CI, 1.52-1.64). The increased mortality associated with these complications was higher in LMICs (58.5%) than in HICs (35.4%). After controlling for coagulopathy complications, treatment intensity, and multiple other factors, the mortality was higher among patients in LMICs than among patients in HICs (odds ratio, 1.45; 95% CI, 1.39-1.51). Conclusion: In a large, international registry of patients hospitalized for COVID-19, coagulopathy complications were mo
- Published
- 2023
4. A multi-country analysis of COVID-19 hospitalizations by vaccination status
- Author
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M., Edelstein M., Escher M., Esperatti M., Santo C. E., Estevao J., Faheem A., Fairfield C. J., Faria P., Farshait N., Fernandes J., Fernandes M. A., Ferrao J., Ferraz M., Ferreira B., Figueiredo-Mello C., Fletcher T., Flynn B., Fontela P., Forsyth S., Foti G., Fowler R. A., Franch-Llasat D., Fraser C., Fraser J. F., Ribeiro A. F., Friedrich C., Fuentes N., G A., Skeie L. G., Gamble C., Garces R., Garcia-Diaz J., Garcia-Gallo E., Gavin A., Germano N., Ghadimi M., Ghisulal P. K., Giani M., Gibson J., Girvan M., Goco G., Gomez-Junyent J., Grable M., Green C. A., Greenhalf W., Griffiths F., Gruner H., Gu Y., Guerguerian A. -M., Guerreiro D., Haber D., Habraken H., Hafez W., Hall M., Halpin S., Hamdan S., Hamers R. L., Hamza S., Hardwick H., Harrison J., Hartman A., Heggelund L., Hendry R., Hennessy M., Hesstvedt L., Higgins D., Higgins R., Hinton S., Ho A., Holter J. C., Horcajada J. P., Ming-Yang Hsu J., Hurd A., Ijaz S., Illana C. 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M., Moro L., Morton B., Mudara C., Muhaisen M., Muller F., Muller K. E., Munshi L., Murthy S., Mustafa D., Nagpal D., Narasimhan M., Nasa P., Nelder M., Neumann E., Ng P. Y., Nichol A. D., Norman L., Notari A., Noursadeghi M., Nusantara D. U., Occhipinti G., O'Hearn K., Oliveira L., Ong D. S. Y., Oosthuyzen W., Openshaw P., Palmarini M., Panarello G., Panda P. K., Parke R., Patricio P., Patterson L., Paul M., Paulos J., Paxton W. A., Pejkovska M., Pereira R., Petrovic M., Pettersen F. O., Pharand S., Phonemixay O., Phoutthavong S., de Piero M., Pimentel C., Pires C., Pitaloka A., Pius R., Poli S., Pollakis G., Post A. -M., Povoas D., Powis J., Praphasiri V., Pritchard M. G., Semedi B. P., Purcell G., Quesada L., Quist-Paulsen E., Rafael A., Rahardjani M., Ramalho J., Rangappa R., Ratsep I., Reeve B., Reikvam D. H., Ren H., Rewa O., Ricchiuto A., Rishu A., Rivera Nunez M. A., Roberts S., Robertson D. L., Roche-Campo F., Rodari P., Roessler B., Rossanese A., Rossetti M., Russell C. D., Holten A. R., Saba I., Sadat M., Sahraei V., Salazar L., Sales G., Sanchez E., Sancho-Shimizu V., Sandhu G., Sandulescu O., Santos M., Sarfo-Mensah S., Sarmiento I. C. E., Saviciute E., Schaffer J., Schwameis M., Schwartz G., Scott J. T., Scott-Brown J., Semple M. G., Sequeira T., Shadowitz E., Shankar A., Shaw C. A., Shaw V., Mohan Shetty D. R., Sibounheuang B., Sigfrid L., Sillaots P., Sin W. C., Sinatti D., Singh M., Skogen V., Smith S., Solomon J., Solomon T., Song R., Spinuzza E., Sriskandan S., Staudinger T., Stecher S. -S., Steinsvik T., Stiksrud B., Streinu-Cercel A., Stuart D., Subekti D., Suen J. Y., Sultana A., Summers C., Suwarti A., Sztajnbok J., Tabrizi S., Taleb S., Tedder R. S., Teixeira J., Tessier-Grenier H., Thompson S., Thomson E. C., Thorpe M., Thwaites R. S., Tonby K., Torre M., Torres Santos-Olmo R. M., Turgeon A. F., Turtle L. C. W., Tveita A., Twardowski P., Ullrich R., Uyeki T. M., Valentini P., Val-Flores L., Varrone M., Vidal J. E., Vieira C., Villanueva J. 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G, Bianco, C, Humaid, F, Bitton, J, Blier, C, Bogaert, D, Borges, D, Bouhmani, D, Bounphiengsy, T, Bountthasavong, L, Klerk, B, Monteiro, F, Brazzi, L, Buchtele, N, Buonsenso, D, Burrell, A, Bustos, I, Caceres, E, Garces, R, Campisi, J, Canepa, C, Caoili, J, Cardellino, C, Cardoso, F, Cardoso, S, Carney, G, Carrier, F, Carson, G, Cascao, M, Casimiro, J, Castaneda, S, Castanheira, N, Cattaneo, P, Cavalin, R, Cavayas, A, Cevik, M, Chaleunphon, B, Chan, A, Chand, M, Chen, A, Cheng, M, Chommanam, D, Chow, Y, Christy, N, Claure-Del Granado, R, Clohisey, S, Codan, C, Connor, M, Cooke, G, Copland, M, Corley, A, Cortegiani, A, Crowl, G, Cruz, C, Csete, M, Custodio, P, da Silva Filipe, A, Dagens, A, Daley, P, Dalloul, Z, Dalton, H, Dalton, J, Damas, J, Daneman, N, Dankwa, E, Dantas, J, D'Aragon, F, De Rose, C, de Silva, T, Dechert, W, Denis, E, Dishon, Y, K, D, Docherty, A, Donnelly, C, Donohue, C, Douangdala, P, Douglas, J, Downer, T, Downing, M, Drake, T, Dryden, M, Dubot-Peres, A, Dudman, S, Dunning, J, Duplaix, M, Durham, L, Dyrhol-Riise, A, Edelstein, M, Escher, M, Esperatti, M, Santo, C, Estevao, J, Faheem, A, Fairfield, C, Faria, P, Farshait, N, Fernandes, J, Fernandes, M, Ferrao, J, Ferraz, M, Ferreira, B, Figueiredo-Mello, C, Fletcher, T, Flynn, B, Fontela, P, Forsyth, S, Foti, G, Fowler, R, Franch-Llasat, D, Fraser, C, Fraser, J, Ribeiro, A, Friedrich, C, Fuentes, N, G, A, Skeie, L, Gamble, C, Garcia-Diaz, J, Garcia-Gallo, E, Gavin, A, Germano, N, Ghadimi, M, Ghisulal, P, Giani, M, Gibson, J, Girvan, M, Goco, G, Gomez-Junyent, J, Grable, M, Green, C, Greenhalf, W, Griffiths, F, Gruner, H, Gu, Y, Guerguerian, A, Guerreiro, D, Haber, D, Habraken, H, Hafez, W, Hall, M, Halpin, S, Hamdan, S, Hamers, R, Hamza, S, Hardwick, H, Harrison, J, Hartman, A, Heggelund, L, Hendry, R, Hennessy, M, Hesstvedt, L, Higgins, D, Higgins, R, Hinton, S, Ho, A, Holter, J, Horcajada, J, Ming-Yang Hsu, J, Hurd, A, Ijaz, S, Illana, C, Inacio, H, Ippolito, M, Isidoro, T, Jaber, H, Jackson, C, Jaworsky, D, Jenum, S, Jouvet, P, Kalicinska, A, Kandel, C, Katz, K, Kaur, A, Keating, S, Kelly, A, Kelly, S, Kennon, K, Keomany, S, Khalid, I, Kho, M, Khoo, S, Kiiza, P, Granerud, B, Kildal, A, Klenerman, P, Bekken, G, Knight, S, Korten, V, Kosgei, C, Kumar, D, Kutsogiannis, D, Lamontagne, F, Lanza, M, Law, A, Lawrence, T, Lee, J, Lee, T, Leeming, G, Letizia, A, Bassi, G, Liang, J, Lim, W, Lind, A, Lissauer, S, Lopes, D, Lyons, R, Machado, S, Majeed, N, Manetta, F, Sant`Ana Malaque, C, Marquis, C, Marsh, L, Marshall, J, Martin-Quiros, A, Martins, A, Rego, C, Martucci, G, Maslove, D, Matthew, C, Mayxay, M, Mcarthur, C, Mccarthy, A, Mcconnochie, R, Mcdonald, S, Mcgeer, A, Mckay, C, Mclean, K, Menon, K, Mentzer, A, Mesquita, A, Meyer, D, Meynert, A, Mihelis, E, Monteiro, A, Montrucchio, G, Moore, S, Cely, L, Moro, L, Morton, B, Mudara, C, Muhaisen, M, Muller, F, Muller, K, Munshi, L, Murthy, S, Mustafa, D, Nagpal, D, Narasimhan, M, Nasa, P, Nelder, M, Neumann, E, Ng, P, Nichol, A, Norman, L, Notari, A, Noursadeghi, M, Nusantara, D, Occhipinti, G, O'Hearn, K, Oliveira, L, Ong, D, Oosthuyzen, W, Openshaw, P, Palmarini, M, Panarello, G, Panda, P, Parke, R, Patricio, P, Patterson, L, Paul, M, Paulos, J, Paxton, W, Pejkovska, M, Pereira, R, Petrovic, M, Pettersen, F, Pharand, S, Phonemixay, O, Phoutthavong, S, de Piero, M, Pimentel, C, Pires, C, Pitaloka, A, Pius, R, Poli, S, Pollakis, G, Post, A, Povoas, D, Powis, J, Praphasiri, V, Pritchard, M, Semedi, B, Purcell, G, Quesada, L, Quist-Paulsen, E, Rafael, A, Rahardjani, M, Ramalho, J, Rangappa, R, Ratsep, I, Reeve, B, Reikvam, D, Ren, H, Rewa, O, Ricchiuto, A, Rishu, A, Rivera Nunez, M, Roberts, S, Robertson, D, Roche-Campo, F, Rodari, P, Roessler, B, Rossanese, A, Rossetti, M, Russell, C, Holten, A, Saba, I, Sadat, M, Sahraei, V, Salazar, L, Sales, G, Sanchez, E, Sancho-Shimizu, V, Sandhu, G, Sandulescu, O, Santos, M, Sarfo-Mensah, S, Sarmiento, I, Saviciute, E, Schaffer, J, Schwameis, M, Schwartz, G, Scott, J, Scott-Brown, J, Semple, M, Sequeira, T, Shadowitz, E, Shankar, A, Shaw, C, Shaw, V, Mohan Shetty, D, Sibounheuang, B, Sigfrid, L, Sillaots, P, Sin, W, Sinatti, D, Singh, M, Skogen, V, Smith, S, Solomon, J, Solomon, T, Song, R, Spinuzza, E, Sriskandan, S, Staudinger, T, Stecher, S, Steinsvik, T, Stiksrud, B, Streinu-Cercel, A, Stuart, D, Subekti, D, Suen, J, Sultana, A, Summers, C, Suwarti, A, Sztajnbok, J, Tabrizi, S, Taleb, S, Tedder, R, Teixeira, J, Tessier-Grenier, H, Thompson, S, Thomson, E, Thorpe, M, Thwaites, R, Tonby, K, Torre, M, Torres Santos-Olmo, R, Turgeon, A, Turtle, L, Tveita, A, Twardowski, P, Ullrich, R, Uyeki, T, Valentini, P, Val-Flores, L, Varrone, M, Vidal, J, Vieira, C, Villanueva, J, Villar, J, Villoldo, A, Vitiello, C, Vongsouvath, M, Wainstein, M, Webb, S, Wei, J, Wesselius, S, Wham, M, White, N, Willems, S, Williams, B, Williams, V, Wils, E, Wittman, J, Yerkovich, S, Yiaye, T, Zahran, M, Zambon, M, Goncalves B. P., Jassat W., Baruch J., Hashmi M., Rojek A., Dasgupta A., Martin-Loeches I., Reyes L. F., Piubelli C., Citarella B. W., Kartsonaki C., Lefevre B., Lopez Revilla J. W., Lunn M., Harrison E. M., Kraemer M. U. G., Shrapnel S., Horby P., Bisoffi Z., Olliaro P. L., Merson L., Abdukahil S. A., Jabal K. A., Salah N. A., Airlangga E., Hssain A. A., Akwani C., Al Qasim E., Alberti A., Aldabbourosama O., Alessi M., Alex B., Al-Fares A., Aliudin J., Alkahlout M., Almasri L., Al-Saba'a Y., Alves R., Cabrita J. A., Amaral M., Ampaw P., Anchan A. J., Angheben A., Arabi Y., Arcadipane A., Archambault P., Arenz L., Arora R., Ashley E. A., Atique A., Atlowly M., Bach B., Baillie J. K., Baird J. K., Balan V., Barbalho R., Barbosa N. Y., Barclay W. S., Barnikel M., Beer N., Begum H., Bellemare D., Beltrame A., Bertoli G., Bianco C., Humaid F. B., Bitton J., Blier C., Bogaert D., Borges D., Bouhmani D., Bounphiengsy T., Bountthasavong L., Klerk B. B. -D., Monteiro F. B., Brazzi L., Buchtele N., Buonsenso D., Burrell A., Bustos I. G., Cabrita J., Caceres E., Garces R. C., Campisi J., Canepa C., Caoili J., Cardellino C. S., Cardoso F., Cardoso S., Carney G., Carrier F. M., Carson G., Cascao M., Casimiro J., Castaneda S., Castanheira N., Cattaneo P., Cavalin R., Cavayas A., Cevik M., Chaleunphon B., Chan A., Chand M., Chen A., Cheng M. P., Chommanam D., Chow Y. P., Christy N., Claure-Del Granado R., Clohisey S., Codan C., Connor M., Cooke G. S., Copland M., Corley A., Cortegiani A., Crowl G., Cruz C., Csete M., Custodio P., da Silva Filipe A., Dagens A., Daley P., Dalloul Z., Dalton H., Dalton J., Damas J., Daneman N., Dankwa E. A., Dantas J., D'Aragon F., De Rose C., de Silva T., Dechert W., Denis E., Dishon Y., k Dhangar, Docherty A. B., Donnelly C. A., Donohue C., Douangdala P., Douglas J. J., Downer T., Downing M., Drake T., Dryden M., Dubot-Peres A., Dudman S., Dunning J., Duplaix M., Durham L., Dyrhol-Riise A. M., Edelstein M., Escher M., Esperatti M., Santo C. E., Estevao J., Faheem A., Fairfield C. J., Faria P., Farshait N., Fernandes J., Fernandes M. A., Ferrao J., Ferraz M., Ferreira B., Figueiredo-Mello C., Fletcher T., Flynn B., Fontela P., Forsyth S., Foti G., Fowler R. A., Franch-Llasat D., Fraser C., Fraser J. F., Ribeiro A. F., Friedrich C., Fuentes N., G A., Skeie L. G., Gamble C., Garces R., Garcia-Diaz J., Garcia-Gallo E., Gavin A., Germano N., Ghadimi M., Ghisulal P. K., Giani M., Gibson J., Girvan M., Goco G., Gomez-Junyent J., Grable M., Green C. A., Greenhalf W., Griffiths F., Gruner H., Gu Y., Guerguerian A. -M., Guerreiro D., Haber D., Habraken H., Hafez W., Hall M., Halpin S., Hamdan S., Hamers R. L., Hamza S., Hardwick H., Harrison J., Hartman A., Heggelund L., Hendry R., Hennessy M., Hesstvedt L., Higgins D., Higgins R., Hinton S., Ho A., Holter J. C., Horcajada J. P., Ming-Yang Hsu J., Hurd A., Ijaz S., Illana C. C., Inacio H., Ippolito M., Isidoro T., Jaber H., Jackson C., Jaworsky D., Jenum S., Jouvet P., Kalicinska A., Kandel C., Katz K., Kaur A., Keating S., Kelly A., Kelly S., Kennon K., Keomany S., Khalid I., Kho M. E., Khoo S., Kiiza P., Granerud B. K., Kildal A. B., Klenerman P., Bekken G. K., Knight S. R., Korten V., Kosgei C., Kumar D., Kutsogiannis D., Lamontagne F., Lanza M., Law A., Lawrence T., Lee J., Lee T. C., Leeming G., Letizia A., Bassi G. L., Liang J., Lim W. S., Lind A., Lissauer S., Lopes D., Lyons R., Machado S., Majeed N. A., Manetta F., Sant`Ana Malaque C. M., Marquis C., Marsh L., Marshall J., Martin-Quiros A., Martins A., Rego C. M., Martucci G., Maslove D., Matthew C., Mayxay M., McArthur C., McCarthy A., McConnochie R., McDonald S. E., McGeer A., McKay C., McLean K. A., Menon K., Mentzer A. J., Mesquita A., Meyer D., Meynert A. M., Mihelis E., Monteiro A., Montrucchio G., Moore S., Moore S. C., Cely L. M., Moro L., Morton B., Mudara C., Muhaisen M., Muller F., Muller K. E., Munshi L., Murthy S., Mustafa D., Nagpal D., Narasimhan M., Nasa P., Nelder M., Neumann E., Ng P. Y., Nichol A. D., Norman L., Notari A., Noursadeghi M., Nusantara D. U., Occhipinti G., O'Hearn K., Oliveira L., Ong D. S. Y., Oosthuyzen W., Openshaw P., Palmarini M., Panarello G., Panda P. K., Parke R., Patricio P., Patterson L., Paul M., Paulos J., Paxton W. A., Pejkovska M., Pereira R., Petrovic M., Pettersen F. O., Pharand S., Phonemixay O., Phoutthavong S., de Piero M., Pimentel C., Pires C., Pitaloka A., Pius R., Poli S., Pollakis G., Post A. -M., Povoas D., Powis J., Praphasiri V., Pritchard M. G., Semedi B. P., Purcell G., Quesada L., Quist-Paulsen E., Rafael A., Rahardjani M., Ramalho J., Rangappa R., Ratsep I., Reeve B., Reikvam D. H., Ren H., Rewa O., Ricchiuto A., Rishu A., Rivera Nunez M. A., Roberts S., Robertson D. L., Roche-Campo F., Rodari P., Roessler B., Rossanese A., Rossetti M., Russell C. D., Holten A. R., Saba I., Sadat M., Sahraei V., Salazar L., Sales G., Sanchez E., Sancho-Shimizu V., Sandhu G., Sandulescu O., Santos M., Sarfo-Mensah S., Sarmiento I. C. E., Saviciute E., Schaffer J., Schwameis M., Schwartz G., Scott J. T., Scott-Brown J., Semple M. G., Sequeira T., Shadowitz E., Shankar A., Shaw C. A., Shaw V., Mohan Shetty D. R., Sibounheuang B., Sigfrid L., Sillaots P., Sin W. C., Sinatti D., Singh M., Skogen V., Smith S., Solomon J., Solomon T., Song R., Spinuzza E., Sriskandan S., Staudinger T., Stecher S. -S., Steinsvik T., Stiksrud B., Streinu-Cercel A., Stuart D., Subekti D., Suen J. Y., Sultana A., Summers C., Suwarti A., Sztajnbok J., Tabrizi S., Taleb S., Tedder R. S., Teixeira J., Tessier-Grenier H., Thompson S., Thomson E. C., Thorpe M., Thwaites R. S., Tonby K., Torre M., Torres Santos-Olmo R. M., Turgeon A. F., Turtle L. C. W., Tveita A., Twardowski P., Ullrich R., Uyeki T. M., Valentini P., Val-Flores L., Varrone M., Vidal J. E., Vieira C., Villanueva J. A., Villar J., Villoldo A., Vitiello C., Vongsouvath M., Wainstein M., Webb S., Wei J., Wesselius S., Wham M., White N., Willems S., Williams B., Williams V., Wils E. -J., Wittman J., Yerkovich S., Yiaye T., Zahran M., and Zambon M.
- Abstract
Background: Individuals vaccinated against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), when infected, can still develop disease that requires hospitalization. It remains unclear whether these patients differ from hospitalized unvaccinated patients with regard to presentation, coexisting comorbidities, and outcomes. Methods: Here, we use data from an international consortium to study this question and assess whether differences between these groups are context specific. Data from 83,163 hospitalized COVID-19 patients (34,843 vaccinated, 48,320 unvaccinated) from 38 countries were analyzed. Findings: While typical symptoms were more often reported in unvaccinated patients, comorbidities, including some associated with worse prognosis in previous studies, were more common in vaccinated patients. Considerable between-country variation in both in-hospital fatality risk and vaccinated-versus-unvaccinated difference in this outcome was observed. Conclusions: These findings will inform allocation of healthcare resources in future surges as well as design of longer-term international studies to characterize changes in clinical profile of hospitalized COVID-19 patients related to vaccination history. Funding: This work was made possible by the UK Foreign, Commonwealth and Development Office and Wellcome (215091/Z/18/Z, 222410/Z/21/Z, 225288/Z/22/Z, and 220757/Z/20/Z); the Bill & Melinda Gates Foundation (OPP1209135); and the philanthropic support of the donors to the University of Oxford's COVID-19 Research Response Fund (0009109). Additional funders are listed in the “acknowledgments” section.
- Published
- 2023
5. Association of Country Income Level With the Characteristics and Outcomes of Critically Ill Patients Hospitalized With Acute Kidney Injury and COVID-19
- Author
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L., Robineau O., Roche-Campo F., Rodari P., Rodeia S., Roessler B., Roger P. -M., Rojek A., Romaru J., Roncon-Albuquerque R., Roriz M., Rosa-Calatrava M., Rose M., Rosenberger D., Rossanese A., Rossetti M., Rossignol B., Rossignol P., Rousset S., Roy C., Roze B., Russell C. D., Ryan M., Ryckaert S., Holten A. R., Saba I., Sadat M., Sahraei V., Saint-Gilles M., Sakiyalak P., Salazar L., Sales G., Sallaberry S., Gandonniere C. S., Salvator H., Sanchez E., Sanchez O., Sanchez-Miralles A., Sancho-Shimizu V., Sandhu G., Sandhu Z., Sandrine P. -F., Sandulescu O., Santos M., Sarfo-Mensah S., Sarmiento I. C. E., Sarton B., Satyapriya S., Satyawati R., Saviciute E., Saw Y. T., Schaffer J., Schermer T., Scherpereel A., Schneider M., Schroll S., Schwameis M., Scott J. T., Scott-Brown J., Sedillot N., Seitz T., Selvarajoo M., Semaille C., Semple M. G., Senian R. B., Senneville E., Sepulveda C., Sequeira F., Sequeira T., Neto A. S., Balazote P. S., Shadowitz E., Shahidan S. A., Shamsah M., Shankar A., Sharjeel S., Sharma P., Shaw C. A., Shaw V., Sheenan J. R., Shi H., Shime N., Shimizu H., Shimizu K., Shum H. P., Mohammed N. S., Siang N. Y., Sibiude J., Siddiqui A., Sigfrid L., Sillaots P., Silva C., Silva R., Silva M. J., Lim Heng B. S., Sin W. C., Singh P., Singh B. C., Sitompul P. A., Sivam K., Skogen V., Smith S., Smood B., Smyth C., Smyth M., Snacken M., So D., Soh T. V., Solomon J., Solomon T., Somers E., Sommet A., Song R., Song M. J., Song T., Chia J. S., Sotto A., Soum E., Sousa M., Sousa A. C., Uva M. S., Souza-Dantas V., Sperry A., Spinuzza E., Sriskandan S., Stabler S., Staudinger T., Stecher S. -S., Steinsvik T., Stienstra Y., Stiksrud B., Stolz E., Stone A., Streinu-Cercel A., Stuart A., Stuart D., Su R., Subekti D., Suen G., Suen J. Y., Sukumar P., Sultana A., Summers C., Supic D., Suppiah D., Surovcova M., Svistunov S. A., Syahrin S., Syrigos K., Sztajnbok J., Szuldrzynski K., Tabrizi S., Taccone F. S., Tagherset L., Taib S. M., Taleb S., Talsma J., Tampubolon M. L., Tan K. K., Tan Y. C., Tanaka H., Tanaka T., Taniguchi H., Tardivon C., Tattevin P., Taufik M. A., Tawfik H., Tedder R. S., Tee T. Y., Teixeira J., Tellier M. -C., Teoh S. K., Teotonio V., Teoule F., Terpstra P., Terrier O., Terzi N., Tessier-Grenier H., Tey A., Mohd Thabit A. A., Tham Z. D., Thangavelu S., Theron E., Thibault V., Thiberville S. -D., Thill B., Thirumanickam J., Thompson S., Thomson D., Thomson E. C., Thorpe M., Thanga Thurai S. R., Thwaites R. S., Tierney P., Tieroshyn V., Timashev P. S., Timsit J. -F., Tissot N., Toal F., Yang Toh J. Z., Toki M., Tonby K., Tonnii S. L., Torre M., Torres A., Torres-Zevallos H., Towers M., Trapani T., Tromeur C., Trontzas I., Trouillon T., Truong J., Tual C., Tubiana S., Tuite H., Turgeon A. F., Turmel J. -M., Turtle L. C. W., Tveita A., Twardowski P., Udy A., Ullrich R., Uribe A., Usman A., Uyeki T. M., Vajdovics C., Val-Flores L., Valran A., Van de Velde S., van den Berge M., van der Palen J., van der Valk P., Van Der Vekens N., Van der Voort P., Van Der Werf S., van Gulik L., Van Hattem J., van Netten C., van Veen I., Vanel N., Vanoverschelde H., Varghese P., Varrone M., Vasudayan S. R., Vauchy C., Veeran S., Veislinger A., Vencken S., Ventura S., Verbon A., Vidal J. E., Vieira C., Villanueva J. A., Villoldo A., Visseaux B., Vitiello C., Vonkeman H., Vuotto F., Wahab N. H., Wahab S. A., Wahid N. A., Walsh L., Wang C. -H., Webb S., Wei J., Wen T. P., Wesselius S., Wham M., Whelan B., White N., Wicky P. H., Wiedemann A., Wijaya S. O., Wille K., Willems S., Williams B., Williams V., Williams P. J., Wils E. -J., Wittman J., Wong C., Wong X. C., Wong Y. S., Wong T. F., Xian G. E., Xian L. S., Kuan P. X., Xynogalas I., Binti Mohd Yakop S. R., Yamazaki M., Yarad E., Yazdanpanah Y., Liang Hing N. Y., Yelnik C., Yeoh C. H., Yerkovich S., Yokoyama T., Yonis H., Yousif O., Zaaqoq A., Zabbe M., Zahid M., Zahran M., Binti Zaidan N. Z., Zambon M., Zambrano M., Zanella A., Zaynah N., Zayyad H., Zoufaly A., and Zucman D.
- Abstract
Introduction: Acute kidney injury (AKI) has been identified as one of the most common and significant problems in hospitalized patients with COVID-19. However, studies examining the relationship between COVID-19 and AKI in low- and low-middle income countries (LLMIC) are lacking. Given that AKI is known to carry a higher mortality rate in these countries, it is important to understand differences in this population. Methods: This prospective, observational study examines the AKI incidence and characteristics of 32,210 patients with COVID-19 from 49 countries across all income levels who were admitted to an intensive care unit during their hospital stay. Results: Among patients with COVID-19 admitted to the intensive care unit, AKI incidence was highest in patients in LLMIC, followed by patients in upper-middle income countries (UMIC) and high-income countries (HIC) (53%, 38%, and 30%, respectively), whereas dialysis rates were lowest among patients with AKI from LLMIC and highest among those from HIC (27% vs. 45%). Patients with AKI in LLMIC had the largest proportion of community-acquired AKI (CA-AKI) and highest rate of in-hospital death (79% vs. 54% in HIC and 66% in UMIC). The association between AKI, being from LLMIC and in-hospital death persisted even after adjusting for disease severity. Conclusions: AKI is a particularly devastating complication of COVID-19 among patients from poorer nations where the gaps in accessibility and quality of healthcare delivery have a major impact on patient outcomes.
- Published
- 2023
6. Liver injury in hospitalized patients with COVID-19: An International observational cohort study
- Author
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H., Panigada M., Pansu N., Papadopoulos A., Parke R., Pasquier J., Pastene B., Dass Pathmanathan M., Patrao L., Patricio P., Patrier J., Patterson L., Paul C., Paul M., Paulos J., Paxton W. A., Payen J. -F., Peariasamy K., Peelman F., Peiffer-Smadja N., Peigne V., Pejkovska M., Peltan I. D., Pereira R., Perez D., Periel L., Perpoint T., Pesenti A., Pestre V., Petrovic M., Petrov-Sanchez V., Pettersen F. O., Peytavin G., Pharand S., Piagnerelli M., Picard W., Picone O., de Piero M., Pierobon C., Piersma D., Pimentel C., Piquard V., Pires C., Pironneau I., Piroth L., Pius R., Plantier L., Png H. S., Poissy J., Pokeerbux R., Poli S., Pollakis G., Ponscarme D., Porto D. B., Post A. -M., Postma D. F., Povoa P., Povoas D., Powis J., Preau S., Prebensen C., Preiser J. -C., Prinssen A., Pritchard M. G., Proenca L., Puechal O., Semedi B. P., Purcell G., Quesada L., Quist-Paulsen E., Quraishi M., Qutishat F. -F., Rabaud C., Rafael A., Rafiq M., Rahman A. K. H. A., Rahman R. A., Rainieri F., Rajahram G. S., Ramakrishnan N., Ramalho J., Ramli A. A., Rammaert B., Ramos G. V., Rana A., Ranjan R., Rapp C., Rasmin M., Ratsep I., Rau C., Ravi T., Rebaudet S., Redl S., Reeve B., Reid L., Reikvam D. H., Reis R., Remppis J., Remy M., Ren H., Renk H., Resseguier A. -S., Revest M., Rewa O., Reyes L. F., Reyes T., Ribeiro M. I., Richardson D., Richier L., Ridzuan S. N. A. A., Rios A. L., Rishu A., Rispal P., Risso K., Nunez M. A. R., Rizer N., Roberto A., Roberts S., Robertson D. L., Robineau O., Roche-Campo F., Rodari P., Rodeia S., Roessler B., Roger P. -M., Roilides E., Rojek A., Romaru J., Roncon-Albuquerque R., Roriz M., Rosa-Calatrava M., Rose M., Rosenberger D., Rossanese A., Rossetti M., Rossignol B., Rossignol P., Rousset S., Roy C., Roze B., Russell C. D., Ryan M., Ryckaert S., Holten A. R., Saba I., Sadat M., Sahraei V., Saint-Gilles M., Sakiyalak P., Salazar L., Sales G., Sallaberry S., Gandonniere C. S., Salvator H., Sanchez O., Sancho-Shimizu V., Sandhu G., Sandhu Z., Sandrine P. -F., Sandulescu O., Santos M., Sarfo-Mensah S., Banheiro B. S., Sarmiento I. C. E., Sarton B., Satyapriya S., Satyawati R., Saviciute E., Savvidou P., Saw Y. T., Schermer T., Scherpereel A., Schneider M., Schwameis M., Scott J. T., Scott-Brown J., Sedillot N., Selvarajoo M., Semaille C., Semple M. G., Senian R. B., Senneville E., Sepulveda C., Sequeira F., Sequeira T., Neto A. S., Shadowitz E., Shahidan S. A., Shamsah M., Sharjeel S., Sharma P., Shaw C. A., Shaw V., Sheenan J. R., Shi H., Shimizu H., Shimizu K., Shrapnel S., Mohammed N. S., Siang N. Y., Sibiude J., Sigfrid L., Sillaots P., Silva M. J., Silva R., Heng B. S. L., Singh B. C., Sitompul P. A., Sivam K., Smith S., Smood B., Smyth M., Snacken M., Soh T. V., Solomon J., Solomon T., Somers E., Sommet A., Song M. J., Song T., Chia J. S., Sonntagbauer M., Soom A. M., Sotto A., Soum E., Sousa A. C., Sousa M., Uva M. S., Souza-Dantas V., Sperry A., Spinuzza E., Sriskandan S., Stabler S., Staudinger T., Stecher S. -S., Steinsvik T., Stienstra Y., Stiksrud B., Stone A., Streinu-Cercel A., Stuart A., Stuart D., Su R., Suen G., Suen J. Y., Sukumar P., Sultana A., Summers C., Suppiah D., Svistunov A., Syahrin S., Sztajnbok J., Szuldrzynski K., Tabrizi S., Tagherset L., Taib S. M., Taleb S., Talsma J., Tampubolon M. L., Tan K. K., Tan Y. C., Tanaka T., Tardivon C., Tattevin P., Tawfik H., Tedder R. S., Tee T. Y., Teixeira J., Tellier M. -C., Teoh S. K., Teoule F., Terpstra P., Terrier O., Terzi N., Tessier-Grenier H., Thabit A. A. M., Tham Z. D., Thangavelu S., Theron E., Thibault V., Thiberville S. -D., Thill B., Thirumanickam J., Thompson S., Thomson D., Thomson E. C., Thurai S. R. T., Thwaites R. S., Tieroshyn V., Timashev P. S., Timsit J. -F., Tissot N., Toal F., Toh J. Z. Y., Tonby K., Tonnii S. L., Torre M., Torres A., Santos-Olmo R. M. T., Torres-Zevallos H., Trapani T., Trioux T., Tromeur C., Trouillon T., Truong J., Tual C., Tubiana S., Tuite H., Turmel J. -M., Turtle L. C. W., Tveita A., Uchiyama M., Udy A., Ullrich R., Uribe A., Usman A., Uyeki T. M., Val-Flores L., Valran A., Van de Velde S., van den Berge M., Van der Feltz M., van der Palen J., van der Valk P., Van Der Vekens N., Van der Voort P., Van Der Werf S., van Gulik L., Van Hattem J., van Netten C., van Veen I., Vanel N., Vanoverschelde H., Varghese P., Varrone M., Vasudayan S. R., Vauchy C., Veeran S., Veislinger A., Vencken S., Ventura S., Verbon A., Vickers J., Vidal J. E., Vieira C., Vijayan D., Villanueva J. A., Villar J., Villeneuve P. -M., Villoldo A., Visseaux B., Vitiello C., Vonkeman H., Vuotto F., Wahab N. H., Wahab S. A., Wahid N. A., Wainstein M., Walsh L., Wang C. -H., Webb S., Wei J., Wen T. P., Wesselius S., Wham M., Whelan B., White N., Wicky P. H., Wiedemann A., Wijaya S. O., Willems S., Williams V., Wils E. -J., Wong C., Wong T. F., Wong X. C., Wong Y. S., Xian G. E., Xian L. S., Xuan K. P., Yakop S. R. B. M., Yamazaki M., Yazdanpanah Y., Hing N. Y. L., Yelnik C., Yeoh C. H., Yerkovich S., Yokoyama T., Yonis H., Yousif O., Zaaqoq A., Zabbe M., Zacharowski K., Zahid M., Zahran M., Zaidan N. Z. B., Zambon M., Zambrano M., Zanella A., Zaynah N., Zayyad H., and Zucman D.
- Abstract
Background Using a large dataset, we evaluated prevalence and severity of alterations in liver enzymes in COVID-19 and association with patient-centred outcomes. Methods We included hospitalized patients with confirmed or suspected SARS-CoV-2 infection from the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) database. Key exposure was baseline liver enzymes (AST, ALT, bilirubin). Patients were assigned Liver Injury Classification score based on 3 components of enzymes at admission: Normal; Stage I) Liver injury: any component between 1-3x upper limit of normal (ULN); Stage II) Severe liver injury: any component ≥3x ULN. Outcomes were hospital mortality, utilization of selected resources, complications, and durations of hospital and ICU stay. Analyses used logistic regression with associations expressed as adjusted odds ratios (OR) with 95% confidence intervals (CI). Results Of 17,531 included patients, 46.2% (8099) and 8.2% (1430) of patients had stage 1 and 2 liver injury respectively. Compared to normal, stages 1 and 2 were associated with higher odds of mortality (OR 1.53 [1.37-1.71]; OR 2.50 [2.10-2.96]), ICU admission (OR 1.63 [1.48-1.79]; OR 1.90 [1.62-2.23]), and invasive mechanical ventilation (OR 1.43 [1.27-1.70]; OR 1.95 (1.55-2.45). Stages 1 and 2 were also associated with higher odds of developing sepsis (OR 1.38 [1.27-1.50]; OR 1.46 [1.25-1.70]), acute kidney injury (OR 1.13 [1.00-1.27]; OR 1.59 [1.32-1.91]), and acute respiratory distress syndrome (OR 1.38 [1.22-1.55]; OR 1.80 [1.49-2.17]). Conclusions Liver enzyme abnormalities are common among COVID-19 patients and associated with worse outcomes.
- Published
- 2023
7. ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19
- Author
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J., Douma R., Dournon N., Downer T., Downey J., Downing M., Drake T., Driscoll A., Dror A. A., Dryden M., Fonseca C. D., Dubee V., Dubos F., Dubot-Peres A., Ducancelle A., Duculan T., Dudman S., Duggal A., Dunand P., Duplaix M., Durante-Mangoni E., Durham L., Dussol B., Duthoit J., Duval X., Dyrhol-Riise A. M., Ean S. C., Echeverria-Villalobos M., Economopoulos G., Edelstein M., Egan S., Eggesbo L. M., Eira C., Sanharawi M. E., Elapavaluru S., Elharrar B., Ellerbroek J., Ellingjord-Dale M., Eloy P., Elshazly T., Elyazar I., Enderle I., Endo T., Eng C. C., Engelmann I., Enouf V., Epaulard O., Escher M., Esperatti M., Esperou H., Esposito-Farese M., Estevao J., Etienne M., Ettalhaoui N., Everding A. G., Evers M., Fabre I., Fabre M., Faheem A., Fahy A., Fairfield C. J., Fakar Z., Fareed K., Faria P., Farooq A., Fateena H., Fatoni A. Z., Faure K., Favory R., Fayed M., Feely N., Feeney L., Fernandes J., Fernandes M. A., Fernandes S., Ferrand F. -X., Devouge E. F., Ferrao J., Ferrari C., Ferraz M., Ferreira B., Ferreira I., Ferreira S., Ferrer-Roca R., Ferriere N., Ficko C., Figueiredo-Mello C., Finlayson W., Fiorda J., Flament T., Flateau C., Fletcher T., Florio L. L., Flynn B., Flynn D., Fogliazza F., Foley C., Foley J., Fomin V., Fonseca T., Fontela P., Forsyth S., Foster D., Foti G., Fourn E., Fowler R. A., Fraher M., Franch-Llasat D., Fraser C., Fraser J. F., Freire M. V., Ribeiro A. F., French C., Friedrich C., Fritz R., Fry S., Fuentes N., Fukuda M., Argin G., Gaborieau V., Gaci R., Gagliardi M., Gagnard J. -C., Gagne N., Gagneux-Brunon A., Gaiao S., Skeie L. G., Gallagher P., Curto E. G., Gamble C., Gani Y., Garan A., Garcia R., Barrio N. G., Garcia-Diaz J., Garimella N., Garofalo F., Garot D., Garrait V., Gauli B., Gault N., Gavin A., Gavrylov A., Gaymard A., Gebauer J., Geraud E., Morlaes L. G., Germano N., Ghisulal P. 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K., Klenerman P., Klont R., Bekken G. K., Knight S. R., Kobbe R., Kodippily C., Vasconcelos M. K., Koirala S., Komatsu M., Korten V., Kosgei C., Kpangon A., Krawczyk K., Krishnan S., Krishnan V., Kruglova O., Kumar D., Kumar G., Kumar M., Vecham P. K., Kuriakose D., Kurtzman E., Kusumastuti N. P., Kutsogiannis D., Kutsyna G., Kyriakoulis K., L'her E., Lachatre M., Lacoste M., Laffey J. G., Lagrange M., Laine F., Lairez O., Lakhey S., Lalueza A., Lambert M., Lamontagne F., Langelot-Richard M., Langlois V., Lantang E., Lanza M., Laouenan C., Laribi S., Lariviere D., Lasry S., Lath S., Latif N., Launay O., Laureillard D., Lavie-Badie Y., Law A., Lawrence C., Lawrence T., Le M., Le Bihan C., Le Bris C., Le Falher G., Le Fevre L., Le Hingrat Q., Le Marechal M., Le Mestre S., Le Moal G., Le Moing V., Le Nagard H., Le Turnier P., Leal E., Santos M. L., Lee B. H., Lee H. G., Lee S. H., Lee T. C., Lee Y. L., Leeming G., Lefebvre B., Lefebvre L., Lefevre B., Legac S., Lelievre J. -D., Lellouche F., Lemaignen A., Lemee V., Lemeur A., Lemmink G., Lene H. S., Lennon J., Leon R., Leone M., Lepiller Q., Lescure F. -X., Lesens O., Lesouhaitier M., Lester-Grant A., Letizia A., Levy B., Levy Y., Levy-Marchal C., Lewandowska K., Bassi G. L., Liang J., Liaquat A., Liegeon G., Lim K. C., Lim W. S., Lima C., Lina B., Lina L., Lind A., Lingad M. K., Lingas G., Lion-Daolio S., Lissauer S., Liu K., Livrozet M., Lizotte P., Loforte A., Lolong N., Loon L. C., Lopes D., Lopez-Colon D., Loschner A. L., Loubet P., Loufti B., Louis G., Lourenco S., Lovelace-Macon L., Low L. L., Lowik M., Loy J. S., Lucet J. C., Bermejo C. L., Luna C. M., Lungu O., Luong L., Luque N., Luton D., Lwin N., Lyons R., Maasikas O., Mabiala O., Macdonald S., Machado M., Macheda G., Sanchez J. M., Madhok J., Madiha H., de la Calle G. M., Magara J., Maglietta G., Mahieu R., Mahy S., Maia A. R., Maier L. S., Maillet M., Maitre T., Majori M., Malfertheiner M., Malik N., Mallon P., Maltez F., Malvy D., Mammi P., Manda V., Mandei J. M., Mandelbrot L., Manetta F., Mankikian J., Manning E., Manuel A., Sant'Ana Malaque C. M., Marino D., Marino F., Markowicz S., Eid C. M., Marques A., Marquis C., Marsh B., Marsh L., Marshal M., Marshall J., Martelli C. T., Martin D. -A., Martin E., Martin-Blondel G., Martin-Loeches I., Martin-Quiros A., Martinelli A., Martinot M., Martins A., Martins J., Martins N., Rego C. M., Martucci G., Martynenko O., Marwali E. M., Marzukie M., Jimenez J. F. M., Maslove D., Mason P., Mason S., Masood S., Nor B. M., Matan M., Fernandes H. M., Mathew M., Mathieu D., Mattei M., Matulevics R., Maulin L., Maxwell M., Maynar J., Mayxay M., Mazzoni T., Evoy N. M., Sweeney L. M., McArthur C., McCarthy A., McCloskey C., McConnochie R., McDermott S., McDonald S. E., McElroy A., McElwee S., McEneany V., McGeer A., McKay C., McKeown J., McLean K. A., McNally P., McNicholas B., McPartlan E., Meaney E., Mear-Passard C., Mechlin M., Meher M., Mehkri O., Mele F., Melo L., Memon K., Mendes J., Menkiti O., Menon K., Mentre F., Mentzer A. J., Mercier E., Mercier N., Merckx A., Mergeay-Fabre M., Mergler B., Meschi T., Mesquita A., Meta R., Metwally O., Meybeck A., Meyer D., Meynert A. M., Meysonnier V., Meziane A., Mezidi M., Michelagnoli G., Michelanglei C., Michelet I., Mihelis E., Mihnovit V., Miranda-Maldonado H., Misnan N. A., Mohamed N. N. E., Mohamed T. J., Moin A., Molina D., Molinos E., Molloy B., Mone M., Monteiro A., Montes C., Montrucchio G., Moore S., Moore S. C., Cely L. M., Moro L., Tutillo D. R. M., Morton B., Motherway C., Motos A., Mouquet H., Perrot C. M., Moyet J., Mudara C., Mufti A. K., Muh N., Muhamad D., Mullaert J., Muller F., Muller K. E., Munblit D., Muneeb S., Munir N., Munshi L., Murphy A., Murphy L., Murris M., Musaab H., Mutti C., Muvindi H., Muyandy G., Myrodia D. M., Mohd-Hanafiah F. N., Nagpal D., Narasimhan M., Narayanan N., Khan R. N., Nazerali-Maitland A., Neant N., Neb H., Necsoi C., Nekliudov N. A., Nelwan E., Neto R., Neumann E., Neves B., Ng P., Ng W., Nghi A., Ngure J., Nguyen D., Choileain O. N., Leathlobhair N. N., Nichol A., Nitayavardhana P., Nonas S., Noordin N. A. M., Noret M., Norharizam N. F. I., Norman L., Notari A., Noursadeghi M., Nowicka K., Nowinski A., Nseir S., Nunez J. I., Nurnaningsih N., Nusantara D. U., Nyamankolly E., Nygaard A. B., Brien F. O., Callaghan A. O., O'callaghan A., O'donnell M., O'halloran S., O'Hearn K., O'Neil C., O'shea L., O'sullivan M., Occhipinti G., Oconnor D., Ogston T., Ogura T., Oh T. -H., Ohshimo S., Oldakowska A., Oliveira J., Oliveira L., Ong D. S. Y., Ong J. Y., Oosthuyzen W., Opavsky A., Openshaw P., Orakzai S., Orozco-Chamorro C. M., Orquera A., Ortoleva J., Osatnik J., Othman S. Z., Otiku P., Ouamara N., Ouissa R., Owyang C., Oziol E., Pagadoy M., Pages J., Palacios A., Palacios M., Palmarini M., Panarello G., Panda P. K., Paneru H., Pang L. H., Panigada M., Pansu N., Papadopoulos A., Parducci P., Paredes Ona E. F., Parke R., Parker M., Parra B., Parrini V., Pasha T., Pasquier J., Pastene B., Patauner F., Patel D., Pathmanathan M. D., Patrao L., Patricio P., Patrier J., Patrizi L., Patterson L., Pattnaik R., Paul C., Paul M., Paulos J., Paxton W. A., Payen J. -F., Peariasamy K., Jimenez M. P., Peek G. J., Peelman F., Peiffer-Smadja N., Peigne V., Pejkovska M., Pelosi P., Peltan I. D., Pereira R., Perez D., Periel L., Perpoint T., Pesenti A., Pestre V., Petrou L., Petrov-Sanchez V., Petrovic M., Pettersen F. O., Peytavin G., Pharand S., Phonemixay O., Piagnerelli M., Picard W., Picone O., de Piero M., Pierobon C., Piersma D., Pimentel C., Pinto R., Pires C., Pironneau I., Piroth L., Pisi R., Pitaloka A., Pius R., Piva S., Plantier L., Png H. S., Poissy J., Pokeerbux R., Pokorska-Spiewak M., Poli S., Pollakis G., Ponscarme D., Popielska J., Porto D. B., Post A. -M., Postma D. F., Povoa P., Povoas D., Powis J., Prapa S., Praphasiri V., Preau S., Prebensen C., Preiser J. -C., Prinssen A., Pritchard M. G., Priyadarshani G. D. D., Proenca L., Pudota S., Puechal O., Semedi B. P., Pulicken M., Puntoni M., Purcell G., Quesada L., Quinones-Cardona V., Gonzalez V. Q., Quist-Paulsen E., Quraishi M., Rabaa M., Rabaud C., Rabindrarajan E., Rafael A., Rafiq M., Ragazzo G., Rahardjani M., Haji Ab Rahman A. K., Rahman R. A., Rahutullah A., Rainieri F., Rajahram G. S., Ramachandran P., Ramakrishnan N., Ramanathan K., Ramli A. A., Rammaert B., Ramos G. V., Rampello A., Rana A., Rangappa R., Ranjan R., Ranza E., Rapp C., Rashan T., Rasheed G., Rasmin M., Ratsep I., Rau C., Rausa F., Ravi T., Raza A., Real A., Rebaudet S., Redl S., Reeve B., Rehman A., Reid L., Reikvam D. H., Reis R., Rello J., Remppis J., Remy M., Ren H., Renk H., Resseguier A. -S., Revest M., Rewa O., Reyes T., Ribeiro M. I., Ricchiuto A., Richardson D., Richier L., Ahmad Ridzuan S. N. A., Riera J., Rios A. L., Rishu A., Rispal P., Risso K., Rivera Nunez M. A., Rizer N., Robba C., Roberto A., Roberts S., Robertson D. L., Robineau O., Roche-Campo F., Rodari P., Rodeia S., Abreu J. R., Roessler B., Roger C., Roger P. -M., Roilides E., Romaru J., Roncon-Albuquerque R., Roriz M., Rosa-Calatrava M., Rose M., Rosenberger D., Mohammad Roslan N. H., Rossanese A., Rossetti M., Rossi S., Rossignol B., Rossignol P., Rousset S., Roy C., Roze B., Rusmawatiningtyas D., Ryan M., Ryckaert S., Holten A. R., Saba I., Sacchelli L., Sadaf S., Sadat M., Sahraei V., Saidani N., Saint-Gilles M., Sakiyalak P., Salahuddin N., Salazar L., Saleem J., Saleh N., Sales G., Sallaberry S., Gandonniere C. S., Salvator H., Sanchez O., Choez X. S., de Oliveira K. S., Sanchez-Miralles A., Sancho-Shimizu V., Sandhu G., Sandhu Z., Sandrine P. -F., Sandulescu O., Santos M., Sarfo-Mensah S., Banheiro B. S., Sarmiento I. C. E., Sarton B., Satya A., Satyapriya S., Satyawati R., Saviciute E., Savvidou P., Saw Y. T., Schaffer J., Schermer T., Scherpereel A., Schneider M., Schroll S., Schwameis M., Schwartz G., Scott J. T., Scott-Brown J., Sedillot N., Seitz T., Selvanayagam J., Selvarajoo M., Semaille C., Semple M. G., Senian R. B., Senneville E., Sepulveda C., Sequeira F., Sequeira T., Neto A. S., Balazote P. S., Shadowitz E., Shahidan S. A., Shamsah M., Shankar A., Sharjeel S., Sharma P., Shaw C. A., Shaw V., Sheharyar A., Shetty R. M., Shetty R., Shi H., Shiban N., Shiekh M., Shiga T., Shime N., Shimizu H., Shimizu K., Shimizu N., Shrestha P. S., Shrestha S. K., Shum H. P., Mohammed N. S., Siang N., Sibiude J., Sibounheuang B., Siddiqui A., Sillaots P., Silva C., Silva M. J., Silva R., Heng B. S. L., Sin W. C., Sinatti D., Singh B. C., Singh P., Sitompul P. A., Sivam K., Skogen V., Smood B., Smyth C., Smyth M., Snacken M., So D., Soh T. V., Solberg L. B., Solomon J., Solomon T., Somers E., Sommet A., Song M. J., Song R., Song T., Chia J. S., Sonntagbauer M., Soom A. M., Soraas A., Soraas C. L., Sotto A., Soum E., Sousa A. C., Sousa M., Uva M. S., Souza-Dantas V., Sperry A., Spinuzza E., Sri Darshana B. P. S. R., Sriskandan S., Stabler S., Staudinger T., Stecher S. -S., Steinsvik T., Stienstra Y., Stiksrud B., Stolz E., Stone A., Streinu-Cercel A., Strudwick S., Stuart A., Stuart D., Subekti D., Suen G., Suen J., Sultana A., Summers C., Supic D., Suppiah D., Surovcova M., Suwarti S., Svistunov A. A., Syahrin S., Syrigos K., Sztajnbok J., Szuldrzynski K., Tabrizi S., Taccone F. S., Tagherset L., Taib S. M., Talarek E., Taleb S., Talsma J., Tamisier R., Tampubolon M. L., Tan K. K., Van Tan L., Tan Y. C., Tanaka C., Tanaka H., Tanaka T., Taniguchi H., Taqdees H., Taqi A., Tardivon C., Tattevin P., Taufik M. A., Tawfik H., Tedder R. S., Tee T., Teixeira J., Tejada S., Tellier M. -C., Teoh S. K., Teotonio V., Teoule F., Terpstra P., Terrier O., Terzi N., Tessier-Grenier H., Tey A., Thabit A. A. M., Thakur A., Tham Z. D., Thangavelu S., Thibault V., Thiberville S. -D., Thill B., Thirumanickam J., Thompson S., Thomson D., Thomson E. C., Thurai S. R. T., Thuy D. B., Thwaites R. S., Ticinesi A., Tierney P., Tieroshyn V., Timashev P. S., Timsit J. -F., Vijayaraghavan B. K. T., Tissot N., Toh J. Z., Toki M., Tonby K., Tonnii S. L., Torres A., Torres M., Santos-Olmo R. M. T., Torres-Zevallos H., Towers M., Trapani T., Treoux T., Trieu H. T., Tromeur C., Trontzas I., Trouillon T., Truong J., Tual C., Tubiana S., Tuite H., Turmel J. -M., Turtle L. C. W., Tveita A., Twardowski P., Uchiyama M., Udayanga P. G. I., Udy A., Ullrich R., Uribe A., Usman A., Uyeki T. M., Vajdovics C., Val-Flores L., Valentini P., Valle A. L., Valran A., Valzano I., Van de Velde S., van den Berge M., Van der Feltz M., van der Palen J., van der Valk P., Van Der Vekens N., Van der Voort P., Van Der Werf S., van Dyk M., van Gulik L., Van Hattem J., van Netten C., Van Twillert G., van Veen I., Vanel N., Vanoverschelde H., Varghese P., Varrone M., Vasudayan S. R., Vauchy C., Veeran S., Veislinger A., Vencken S., Ventura S., Verbon A., Vickers J., Vidal J. E., Vieira C., Vijayan D., Villanueva J. A., Villar J., Villeneuve P. -M., Villoldo A., Van Vinh Chau N., Vishwanathan G., Visseaux B., Visser H., Vitiello C., Vongsouvath M., Vonkeman H., Vuotto F., Wahab N. H., Wahab S. A., Wahid N. A., Wainstein M., Wan Muhd Shukeri W. F., Wang C. -H., Webb S., Weil K., Wen T. P., Wesselius S., West T. E., Wham M., Whelan B., White N., Wicky P. H., Wiedemann A., Wijaya S. O., Wille K., Willems S., Williams V., Wils E. -J., Wong C., Wong T. F., Wong X. C., Wong Y. S., Wright N., Xian G. E., Xian L. S., Xuan K. P., Xynogalas I., Yacoub S., Mohdyakop S. R. B., Yamazaki M., Yazdanpanah Y., Hing N. L., Yelnik C., Yeoh C. H., Yerkovich S., Yiaye T., Yokoyama T., Yonis H., Yousif O., Yuliarto S., Zaaqoq A., Zabbe M., Zacharowski K., Zahid M., Zahran M., Zaidan N. Z. B., Zambon M., Zambrano M., Zanella A., Zawadka K., Zaynah N., Zoufaly A., and Zucman D.
- Abstract
The International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) COVID-19 dataset is one of the largest international databases of prospectively collected clinical data on people hospitalized with COVID-19. This dataset was compiled during the COVID-19 pandemic by a network of hospitals that collect data using the ISARIC-World Health Organization Clinical Characterization Protocol and data tools. The database includes data from more than 705,000 patients, collected in more than 60 countries and 1,500 centres worldwide. Patient data are available from acute hospital admissions with COVID-19 and outpatient follow-ups. The data include signs and symptoms, pre-existing comorbidities, vital signs, chronic and acute treatments, complications, dates of hospitalization and discharge, mortality, viral strains, vaccination status, and other data. Here, we present the dataset characteristics, explain its architecture and how to gain access, and provide tools to facilitate its use.
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- 2022
8. CO105 The Association of Sars-Cov-2 Infection and Tuberculosis Disease with Unfavorable Treatment Outcomes: A Systematic Review
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Vadlamudi, N., primary, Basham, C.A., additional, Johnston, J.C., additional, Khan, F.A., additional, Migliori, G.B., additional, Centis, R., additional, D'Ambrosio, L., additional, Jassat, W., additional, Davies, M.A., additional, Schwartzman, K., additional, and Campbell, J.R., additional
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- 2023
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9. International Pediatric COVID-19 Severity Over the Course of the Pandemic
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Zhu, Y, Almeida, FJ, Baillie, JK, Bowen, AC, Britton, PN, Brizuela, ME, Buonsenso, D, Burgner, D, Chew, KY, Chokephaibulkit, K, Cohen, C, Cormier, SA, Crawford, N, Curtis, N, Farias, CGA, Gilks, CF, von Gottberg, A, Hamer, D, Jarovsky, D, Jassat, W, Jesus, AR, Kemp, LS, Khumcha, B, McCallum, G, Miller, JE, Morello, R, Munro, APS, Openshaw, PJM, Padmanabhan, S, Phongsamart, W, Reubenson, G, Ritz, N, Rodrigues, F, Rungmaitree, S, Russell, F, Safadi, MAP, Saner, C, Semple, MG, da Silva, DGBP, de Sousa, LMM, Souza, MDM, Spann, K, Walaza, S, Wolter, N, Xia, Y, Yeoh, DK, Zar, HJ, Zimmermann, P, Short, KR, Zhu, Y, Almeida, FJ, Baillie, JK, Bowen, AC, Britton, PN, Brizuela, ME, Buonsenso, D, Burgner, D, Chew, KY, Chokephaibulkit, K, Cohen, C, Cormier, SA, Crawford, N, Curtis, N, Farias, CGA, Gilks, CF, von Gottberg, A, Hamer, D, Jarovsky, D, Jassat, W, Jesus, AR, Kemp, LS, Khumcha, B, McCallum, G, Miller, JE, Morello, R, Munro, APS, Openshaw, PJM, Padmanabhan, S, Phongsamart, W, Reubenson, G, Ritz, N, Rodrigues, F, Rungmaitree, S, Russell, F, Safadi, MAP, Saner, C, Semple, MG, da Silva, DGBP, de Sousa, LMM, Souza, MDM, Spann, K, Walaza, S, Wolter, N, Xia, Y, Yeoh, DK, Zar, HJ, Zimmermann, P, and Short, KR
- Abstract
IMPORTANCE: Multiple SARS-CoV-2 variants have emerged over the COVID-19 pandemic. The implications for COVID-19 severity in children worldwide are unclear. OBJECTIVE: To determine whether the dominant circulating SARS-CoV-2 variants of concern (VOCs) were associated with differences in COVID-19 severity among hospitalized children. DESIGN, SETTING, AND PARTICIPANTS: Clinical data from hospitalized children and adolescents (younger than 18 years) who were SARS-CoV-2 positive were obtained from 9 countries (Australia, Brazil, Italy, Portugal, South Africa, Switzerland, Thailand, UK, and the US) during 3 different time frames. Time frames 1 (T1), 2 (T2), and 3 (T3) were defined to represent periods of dominance by the ancestral virus, pre-Omicron VOCs, and Omicron, respectively. Age groups for analysis were younger than 6 months, 6 months to younger than 5 years, and 5 to younger than 18 years. Children with an incidental positive test result for SARS-CoV-2 were excluded. EXPOSURES: SARS-CoV-2 hospitalization during the stipulated time frame. MAIN OUTCOMES AND MEASURES: The severity of disease was assessed by admission to intensive care unit (ICU), the need for ventilatory support, or oxygen therapy. RESULTS: Among 31 785 hospitalized children and adolescents, the median age was 4 (IQR 1-12) years and 16 639 were male (52.3%). In children younger than 5 years, across successive SARS-CoV-2 waves, there was a reduction in ICU admission (T3 vs T1: risk ratio [RR], 0.56; 95% CI, 0.42-0.75 [younger than 6 months]; RR, 0.61, 95% CI; 0.47-0.79 [6 months to younger than 5 years]), but not ventilatory support or oxygen therapy. In contrast, ICU admission (T3 vs T1: RR, 0.39, 95% CI, 0.32-0.48), ventilatory support (T3 vs T1: RR, 0.37; 95% CI, 0.27-0.51), and oxygen therapy (T3 vs T1: RR, 0.47; 95% CI, 0.32-0.70) decreased across SARS-CoV-2 waves in children 5 years to younger than 18 years old. The results were consistent when data were restricted to unvaccinated children. CONC
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- 2023
10. Leveraging epidemiology as a decision support tool during the COVID-19 epidemic in South Africa
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Silal, SP, Groome, MJ, Govender, N, Pulliam, JRC, Ramadan, OP, Puren, A, Jassat, W, Leonard, E, Moultrie, H, Meyer-Rath, KG, Ramkrishna, W, Langa, T, Furumele, T, Moonasar, D, Cohen, C, and Walaza, S
- Subjects
South Africa ,Government ,COVID-19 ,Humans ,Public Health ,General Medicine ,Epidemics - Abstract
By May 2021, South Africa (SA) had experienced two ‘waves’ of COVID-19 infections, with an initial peak of infections reached in July 2020, followed by a larger peak of infections in January 2021. Public health decisions rely on accurate and timely disease surveillance and epidemiological analyses, and accessibility of data at all levels of government is critical to inform stakeholders to respond effectively. In this paper, we describe the adaptation, development and operation of epidemiological surveillance and modelling systems in SA in response to the COVID-19 epidemic, including data systems for monitoring laboratory-confirmed COVID-19 cases, hospitalisations, mortality and recoveries at a national and provincial level, and how these systems were used to inform modelling projections and public health decisions. Detailed descriptions on the characteristics and completeness of individual datasets are not provided in this paper. Rapid development of robust data systems was necessary to support the response to the SA COVID-19 epidemic. These systems produced data streams that were used in decision-making at all levels of government. While much progress was made in producing epidemiological data, challenges remain to be overcome to address gaps to better prepare for future waves of COVID-19 and other health emergencies.
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- 2022
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11. OP040 [Infections » Covid-19 / Sars-CoV-2]: PEDIATRIC COVID-19 MORTALITY: TWO-SIDED CHALLENGES FROM HEALTH RESOURCE DISPARITY
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Marwali, E. M., primary, Kekalih, A., additional, Yuliarto, S., additional, Wati, D. K., additional, Rayhan, M., additional, Valerie, I. C., additional, Cho, H. J., additional, Jassat, W., additional, Blumberg, L., additional, Masha, M., additional, Semple, M. G., additional, Swann, O. V., additional, Popielska, J., additional, Murthy, S., additional, Fowler, R., additional, Guerguerian, A. M., additional, Cercel, A. S., additional, Pathmanathan, M. D., additional, Citarella, B., additional, Rojek, A., additional, Kartsonaki, C., additional, Gonçalves, B., additional, Merson, L., additional, and Dalton, H., additional
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- 2022
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12. The value of open-source clinical science in pandemic response: lessons from ISARIC
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Abbas, A, Abdukahil, S, Abdulkadir, N, Abe, R, Abel, L, Absil, L, Acharya, S, Acker, A, Adachi, S, Adam, E, Adriao, D, Ageel, S, Ahmed, S, Ain, Q, Ainscough, K, Aisa, T, Ait Hssain, A, Ait Tamlihat, Y, Akimoto, T, Akmal, E, Al Qasim, E, Alalqam, R, Alam, T, Al-dabbous, T, Alegesan, S, Alegre, C, Alessi, M, Alex, B, Alexandre, K, Al-Fares, A, Alfoudri, H, Ali, I, Ali Shah, N, Alidjnou, K, Aliudin, J, Alkhafajee, Q, Allavena, C, Allou, N, Altaf, A, Alves, J, Alves, R, Amaral, M, Amira, N, Ammerlaan, H, Ampaw, P, Andini, R, Andrejak, C, Angheben, A, Angoulvant, F, Ansart, S, Anthonidass, S, Antonelli, M, Antunes de Brito, C, Anwar, K, Apriyana, A, Arabi, Y, Aragao, I, Arali, R, Arancibia, F, Araujo, C, Arcadipane, A, Archambault, P, Arenz, L, Arlet, J, Arnold-Day, C, Aroca, A, Arora, L, Arora, R, Artaud-Macari, E, Aryal, D, Asaki, M, Asensio, A, Ashley, E, Ashraf, M, Ashraf, S, Asim, M, Assie, J, Asyraf, A, Atique, A, Attanyake, A, Auchabie, J, Aumaitre, H, Auvet, A, Azemar, L, Azoulay, C, Bach, B, Bachelet, D, Badr, C, Baig, N, Baillie, J, Baird, J, Bak, E, Bakakos, A, Bakar, N, Bal, A, Balakrishnan, M, Balan, V, Bani-Sadr, F, Barbalho, R, Barbosa, N, Barclay, W, Barnett, S, Barnikel, M, Barrasa, H, Barrelet, A, Barrigoto, C, Bartoli, M, Bartone, C, Baruch, J, Bashir, M, Basmaci, R, Basri, M, Bastos, D, Battaglini, D, Bauer, J, Bautista Rincon, D, Bazan Dow, D, Bedossa, A, Bee, K, Behilill, S, Beishuizen, A, Beljantsev, A, Bellemare, D, Beltrame, A, Beltrao, B, Beluze, M, Benech, N, Benjiman, L, Benkerrou, D, Bennett, S, Bento, L, Berdal, J, Bergeaud, D, Bergin, H, Bernal Sobrino, J, Bertoli, G, Bertolino, L, Bessis, S, Betz, A, Bevilcaqua, S, Bezulier, K, Bhatt, A, Bhavsar, K, Bianchi, I, Bianco, C, Bidin, F, Bikram Singh, M, Bin Humaid, F, Bin Kamarudin, M, Bissuel, F, Biston, P, Bitker, L, Blanco-Schweizer, P, Blier, C, Bloos, F, Blot, M, Blumberg, L, Boccia, F, Bodenes, L, Bogaarts, A, Bogaert, D, Boivin, A, Bolze, P, Bompart, F, Bonfasius, A, Borges, D, Borie, 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P., Coca N., Codan C., Cody C., Coelho A., Coles M., Colin G., Collins M., Colombo S. M., Combs P., Connolly J., Connor M., Conrad A., Contreras S., Conway E., Cooke G. S., Copland M., Cordel H., Corley A., Cormican S., Cornelis S., Cornet A. D., Corpuz A. J., Cortegiani A., Corvaisier G., Costigan E., Couffignal C., Couffin-Cadiergues S., Courtois R., Cousse S., Cregan R., Crepy D'Orleans C., Croonen S., Crowl G., Crump J., Cruz C., Cruz Berm J. L., Cruz Rojo J., Csete M., Cucino A., Cullen A., Cullen C., Cummings M., Curley G., Curlier E., Curran C., Custodio P., da Silva Filipe A., Da Silveira C., Dabaliz A. -A., Dagens A., Dahly D., Dalton H., Dalton J., Daly S., D'Amico F., Daneman N., Daniel C., Dankwa E. A., Dantas J., D'Aragon F., de Boer M., de Loughry G., de Mendoza D., De Montmollin E., de Oliveira Franca R. F., de Pinho Oliveira A. I., De Rosa R., de Silva T., de Vries P., Deacon J., Dean D., Debard A., DeBenedictis B., Debray M. -P., DeCastro N., Dechert W., Deconninck L., Decours R., Defous E., Delacroix I., Delaveuve E., Delavigne K., Delfos N. M., Deligiannis I., Dell'Amore A., Delmas C., Delobel P., Delsing C., Demonchy E., Denis E., Deplanque D., Depuydt P., Desai M., Descamps D., Desvallee M., Dewayanti S., Diallo A., Diamantis S., Dias A., Diaz P., Diaz R., Diaz Diaz J. J., Didier K., Diehl J. -L., Dieperink W., Dimet J., Dinot V., Diop F., Diouf A., Dishon Y., Dixit D., Djossou F., Docherty A. B., Doherty H., Dondorp A. M., Dong A., Donnelly C. A., Donnelly M., Donohue C., Donohue S., Donohue Y., Doran C., Doran P., Dorival C., D'Ortenzio E., Douglas J. J., Douma R., Dournon N., Downer T., Downey J., Downing M., Drake T., Driscoll A., Dryden M., Duarte Fonseca C., Dubee V., Dubos F., Ducancelle A., Duculan T., Dudman S., Duggal A., Dunand P., Dunning J., Duplaix M., Durante-Mangoni E., Durham III L., Dussol B., Duthoit J., Duval X., Dyrhol-Riise A. M., Ean S. C., Echeverria-Villalobos M., Egan S., Eira C., El Sanharawi M., Elapavaluru S., Elharrar B., Ellerbroek J., Eloy P., Elshazly T., Elyazar I., Enderle I., Endo T., Eng C. C., Engelmann I., Enouf V., Epaulard O., Escher M., Esperatti M., Esperou H., Esposito-Farese M., Estevao J., Etienne M., Ettalhaoui N., Everding A. G., Evers M., Fabre I., Fabre M., Faheem A., Fahy A., Fairfield C. J., Fakar Z., Faria P., Farooq A., Farrar J. J., Farshait N., Fateena H., Fatoni A. 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W., Hardwick H., Harrison E. M., Harrison J., Harrison S. B. E., Hartman A., Hashmi J., Hashmi M., Hayat M., Hayes A., Hays L., Heerman J., Heggelund L., Hendry R., Hennessy M., Henriquez A., Hentzien M., Herekar F., Hernandez-Montfort J., Herr D., Hershey A., Hesstvedt L., Hidayah A., Higgins D., Higgins E., HigginsOKeeffe G., Hinchion R., Hinton S., Hiraiwa H., Hitoto H., Ho A., Ho Y. B., Hoctin A., Hoffmann I., Hoh W. H., Hoiting O., Holt R., Holter J. C., Horby P., Horcajada J. P., Hoshino K., Houas I., Hough C. L., Houltham S., Hsu J. M. -Y., Hulot J. -S., Hussain I., Ijaz S., Illes H. -G., Imbert P., Imran M., Imran Sikander R., Inacio H., Infante Dominguez C., Ing Y. S., Iosifidis E., Ippolito M., Isgett S., Ishani P. G. P. I., Isidoro T., Ismail N., Isnard M., Itai J., Ito A., Ivulich D., Jaafar D., Jaafoura S., Jabot J., Jackson C., Jamieson N., Jaquet P., Jassat W., Jaud-Fischer C., Jaureguiberry S., Javidfar J., Jawad I., Jaworsky D., Jayakumar D., Jego F., Jelani A. 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B., Kimmoun A., Kindgen-Milles D., King A., Kitamura N., Klenerman P., Klont R., Kloumann Bekken G., Knight S., Kobbe R., Kodippily C., Kohns Vasconcelos M., Koirala S., Komatsu M., Korten V., Kosgei C., Kpangon A., Krawczyk K., Krishnan S., Krishnan V., Kruglova O., Kumar A., Kumar D., Kumar G., Kumar M., Kumar Vecham P., Kuriakose D., Kurtzman E., Kusumastuti N. P., Kutsogiannis D., Kutsyna G., Kyriakoulis K., Lachatre M., Lacoste M., Laffey J. G., Lagrange M., Laine F., Lairez O., Lakhey S., Lalueza A., Lambert M., Lamontagne F., Langelot-Richard M., Langlois V., Lantang E. Y., Lanza M., Laouenan C., Laribi S., Lariviere D., Lasry S., Latif N., Launay O., Laureillard D., Lavie-Badie Y., Law A., Lawrence C., Lawrence T., Le M., Le Bihan C., Le Bris C., Le Falher G., Le Fevre L., Le Hingrat Q., Le Marechal M., Le Mestre S., Le Moal G., Le Moing V., Le Nagard H., Le Turnier P., Leal E., Leal Santos M., Lee B. H., Lee H. G., Lee J., Lee S. H., Lee T. C., Lee Y. L., Leeming G., Lefebvre B., Lefebvre L., Lefevre B., LeGac S., Lelievre J. -D., Lellouche F., Lemaignen A., Lemee V., Lemeur A., Lemmink G., Lene H. S., Lennon J., Leon R., Leone M., Lepiller Q., Lescure F. -X., Lesens O., Lesouhaitier M., Lester-Grant A., Levy B., Levy Y., Levy-Marchal C., Lewandowska K., L'Her E., Li Bassi G., Liang J., Liaquat A., Liegeon G., Lim K. C., Lim W. S., Lima C., Lina B., Lina L., Lind A., Lingas G., Lion-Daolio S., Lissauer S., Liu K., Livrozet M., Lizotte P., Loforte A., Lolong N., Loon L. C., Lopes D., Lopez-Colon D., Loschner A. L., Loubet P., Loufti B., Louis G., Lourenco S., Lovelace-Macon L., Low L. L., Lowik M., Loy J. S., Lucet J. C., Lumbreras Bermejo C., Luna C. M., Lungu O., Luong L., Luque N., Luton D., Lwin N., Lyons R., Maasikas O., Mabiala O., MacDonald S., Machado M., Macheda G., Macias Sanchez J., Madhok J., Maestro de la Calle G., Mahieu R., Mahy S., Maia A. R., Maier L. S., Maillet M., Maitre T., Malfertheiner M., Malik N., Mallon P., Maltez F., Malvy D., Manda V., Mandei J. M., Mandelbrot L., Manetta F., Mangal K., Mankikian J., Manning E., Manuel A., Maria Sant`Ana Malaque C., Marino D., Marino F., Markowicz S., Maroun Eid C., Marques A., Marquis C., Marsh B., Marsh L., Marshal M., Marshall J., Martelli C. T., Martin D. -A., Martin E., Martin-Blondel G., Martinelli A., Martin-Loeches I., Martinot M., Martin-Quiros A., Martins A., Martins J., Martins N., Martins Rego C., Martucci G., Martynenko O., Marwali E. M., Marzukie M., Masa Jimenez J. F., Maslove D., Mason P., Mason S., Masood S., Mat Nor B., Matan M., Mateus Fernandes H., Mathew M., Mathieu D., Mattei M., Matulevics R., Maulin L., Maxwell M., Maynar J., Mazzoni T., Mc Sweeney L., McAndrew L., McArthur C., McCarthy A., McCloskey C., McConnochie R., McDermott S., McDonald S. E., McElroy A., McElwee S., McEneany V., McEvoy N., McGeer A., McKay C., McKeown J., McLean K. A., McNally P., McNicholas B., McPartlan E., Meaney E., Mear-Passard C., Mechlin M., Meher M., Mehkri O., Mele F., Melo L., Memon K., Mendes J. J., Menkiti O., Menon K., Mentre F., Mentzer A. J., Mercier E., Mercier N., Merckx A., Mergeay-Fabre M., Mergler B., Merson L., Mesquita A., Metwally O., Meybeck A., Meyer D., Meynert A. M., Meysonnier V., Meziane A., Mezidi M., Michelagnoli G., Michelanglei C., Michelet I., Mihelis E., Mihnovit V., Miranda-Maldonado H., Misnan N. A., Mohamed N. N. E., Mohamed T. J., Moin A., Molina D., Molinos E., Molloy B., Mone M., Monteiro A., Montes C., Montrucchio G., Moore S., Moore S. C., Morales Cely L., Moro L., Morocho Tutillo D. R., Morton B., Motherway C., Motos A., Mouquet H., Mouton Perrot C., Moyet J., Mudara C., Mufti A. K., Muh N. Y., Muhamad D., Mullaert J., Muller F., Muller K. E., Munblit D., Muneeb S., Munir N., Munshi L., Murphy A., Murphy L., Murris M., Murthy S., Musaab H., Muyandy G., Myrodia D. M., N N., Nagpal D., Nagrebetsky A., Narasimhan M., Narayanan N., Nasim Khan R., Nazerali-Maitland A., Neant N., Neb H., Nekliudov N. A., Nelwan E., Neto R., Neumann E., Neves B., Ng P. Y., Nghi A., Nguyen D., Ni Choileain O., Ni Leathlobhair N., Nichol A., Nitayavardhana P., Nonas S., Noordin N. A. M., Noret M., Norharizam N. F. I., Norman L., Notari A., Noursadeghi M., Nowicka K., Nowinski A., Nseir S., Nunez J. I., Nurnaningsih N., Nyamankolly E., O Brien F., O'Callaghan A., Occhipinti G., OConnor D., O'Donnell M., Ogston T., Ogura T., Oh T. -H., O'Halloran S., O'Hearn K., Ohshimo S., Oldakowska A., Oliveira J., Oliveira L., Olliaro P. L., O'Neil C., Ong D. S. Y., Ong J. Y., Oosthuyzen W., Opavsky A., Openshaw P., Orakzai S., Orozco-Chamorro C. M., Orquera A., Ortoleva J., Osatnik J., O'Shea L., O'Sullivan M., Othman S. Z., Ouamara N., Ouissa R., Owyang C., Oziol E., Pabasara H. M. U., Pagadoy M., Pages J., Palacios A., Palacios M., Palmarini M., Panarello G., Panda P. K., Paneru H., Pang L. H., Panigada M., Pansu N., Papadopoulos A., Parke R., Parker M., Parra B., Parrini V., Pasha T., Pasquier J., Pastene B., Patauner F., Patel J., Pathmanathan M. D., Patrao L., Patricio P., Patrier J., Patterson L., Pattnaik R., Paul C., Paul M., Paulos J., Paxton W. A., Payen J. -F., Peariasamy K., Pedrera Jimenez M., Peek G. J., Peelman F., Peiffer-Smadja N., Peigne V., Pejkovska M., Pelosi P., Peltan I. D., Pereira R., Perez D., Periel L., Perpoint T., Pesenti A., Pestre V., Petrou L., Petrov-Sanchez V., Pettersen F. O., Peytavin G., Pharand S., Piagnerelli M., Picard W., Picone O., de Piero M., Pierobon C., Piersma D., Pimentel C., Pinto R., Pires C., Pironneau I., Piroth L., Pius R., Piva S., Plantier L., Plotkin D., Png H. S., Poissy J., Pokeerbux R., Pokorska-Spiewak M., Poli S., Pollakis G., Ponscarme D., Popielska J., Post A. -M., Postma D. F., Povoa P., Povoas D., Powis J., Prapa S., Preau S., Prebensen C., Preiser J. -C., Prinssen A., Pritchard M. G., Priyadarshani G. D. D., Proenca L., Pudota S., Puechal O., Pujo Semedi B., Pulicken M., Puntoni M., Purcell G., Quesada L., Quinones-Cardona V., Quiros Gonzalez V., Quist-Paulsen E., Quraishi M., Rabaa M., Rabaud C., Rabindrarajan E., Rafael A., Rafiq M., Ragazzo G., Rahman A. K. H. A., Rahman R. A., Rahutullah A., Rainieri F., Rajahram G. S., Rajapakse N., Ralib A., Ramakrishnan N., Ramanathan K., Ramli A. A., Rammaert B., Ramos G. V., Rana A., Rangappa R., Ranjan R., Rapp C., Rashan A., Rashan T., Rasheed G., Rasmin M., Ratsep I., Rau C., Ravi T., Raza A., Real A., Rebaudet S., Redl S., Reeve B., Rehan A., Rehman A., Reid L., Reikvam D. H., Reis R., Rello J., Remppis J., Remy M., Ren H., Renk H., Resende L., Resseguier A. -S., Revest M., Rewa O., Reyes L. F., Reyes T., Ribeiro M. I., Richardson D., Richier L., Ridzuan S. N. A. A., Riera J., Rios A. L., Rishu A., Rispal P., Risso K., Rivera Nunez M. A., Rizer N., Robb D., Robba C., Roberto A., Roberts S., Robertson D. L., Robineau O., Roche-Campo F., Rodari P., Rodeia S., Rodriguez Abreu J., Roessler B., Roger C., Roger P. -M., Roilides E., Rojek A., Romaru J., Roncon-Albuquerque R., Roriz M., Rosa-Calatrava M., Rose M., Rosenberger D., Rossanese A., Rossetti M., Rossignol B., Rossignol P., Rousset S., Roy C., Roze B., Rusmawatiningtyas D., Russell C. D., Ryan M., Ryckaert S., Rygh Holten A., Saba I., Sadaf S., Sadat M., Sahraei V., Saint-Gilles M., Sakiyalak P., Salahuddin N., Salazar L., Saleem J., Sales G., Sallaberry S., Salmon Gandonniere C., Salvator H., Sanchez O., Sanchez Choez X., Sanchez de Oliveira K., Sanchez-Miralles A., Sancho-Shimizu V., Sandhu G., Sandhu Z., Sandrine P. -F., Sandulescu O., Santos M., Sarfo-Mensah S., Sarmento Banheiro B., Sarmiento I. C. E., Sarton B., Satyapriya S., Satyawati R., Saviciute E., Savio R., Savvidou P., Saw Y. T., Schaffer J., Schermer T., Scherpereel A., Schneider M., Schroll S., Schwameis M., Schwartz G., Scott J. T., Scott-Brown J., Sedillot N., Seitz T., Selvanayagam J., Selvarajoo M., Semaille C., Semple M. G., Senian R. B., Senneville E., Sepulveda C., Sequeira F., Sequeira T., Serpa Neto A., Serrano Balazote P., Shadowitz E., Shahidan S. A., Shahnaz Hasan M., Shamsah M., Shankar A., Sharjeel S., Sharma P., Shaw C. A., Shaw V., Shi H., Shiban N., Shiekh M., Shiga T., Shime N., Shimizu H., Shimizu K., Shimizu N., Shindo N., Shrapnel S., Shum H. P., Si Mohammed N., Siang N. Y., Sibiude J., Siddiqui A., Sigfrid L., Sillaots P., Silva C., Silva M. J., Silva R., Sim Lim Heng B., Sin W. C., Singh B. C., Singh P., Sitompul P. A., Sivam K., Skogen V., Smith S., Smood B., Smyth C., Smyth M., Snacken M., So D., Soh T. V., Solis M., Solomon J., Solomon T., Somers E., Sommet A., Song M. J., Song R., Song T., Song Chia J., Sonntagbauer M., Soom A. M., Sotto A., Soum E., Sousa A. C., Sousa M., Sousa Uva M., Souza-Dantas V., Sperry A., Spinuzza E., Sri Darshana B. P. S. R., Sriskandan S., Stabler S., Staudinger T., Stecher S. -S., Steinsvik T., Stienstra Y., Stiksrud B., Stolz E., Stone A., Streinu-Cercel A., Strudwick S., Stuart A., Stuart D., Subekti D., Suen G., Suen J. Y., Sukumar P., Sultana A., Summers C., Supic D., Suppiah D., Surovcova M., Suwarti S., Svistunov A. A., Syahrin S., Syrigos K., Sztajnbok J., Szuldrzynski K., Tabrizi S., Taccone F. S., Tagherset L., Taib S. M., Talarek E., Taleb S., Talsma J., Tampubolon M. L., Tan K. K., Tan L. V., Tan Y. C., Tanaka C., Tanaka H., Tanaka T., Taniguchi H., Tanveer H., Taqdees H., Taqi A., Tardivon C., Tattevin P., Taufik M. A., Tawfik H., Tedder R. S., Tee T. Y., Teixeira J., Tejada S., Tellier M. -C., Teoh S. K., Teotonio V., Teoule F., Terpstra P., Terrier O., Terzi N., Tessier-Grenier H., Tey A., Thabit A. A. M., Tham Z. D., Thangavelu S., Thibault V., Thiberville S. -D., Thill B., Thirumanickam J., Thompson S., Thomson D., Thomson E. C., Thurai S. R. T., Thuy D. B., Thwaites R. 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E., Vieira C., Vijayan D., Villanueva J. A., Villar J., Villeneuve P. -M., Villoldo A., Vinh Chau N. V., Visseaux B., Visser H., Vitiello C., Vonkeman H., Vuotto F., Wahab N. H., Wahab S. A., Wahid N. A., Wainstein M., Wan Muhd Shukeri W. F., Wang C. -H., Webb S. A., Wei J., Weil K., Wen T. P., Wesselius S., West T. E., Wham M., Whelan B., White N., Wicky P. H., Wiedemann A., Wijaya S. O., Wille K., Willems S., Williams V., Wils E. -J., Wing Yiu N., Wong C., Wong T. F., Wong X. C., Wong Y. S., Xian G. E., Xian L. S., Xuan K. P., Xynogalas I., Yacoub S., Yakop S. R. B. M., Yamazaki M., Yazdanpanah Y., Yee Liang Hing N., Yelnik C., Yeoh C. H., Yerkovich S., Yokoyama T., Yonis H., Yousif O., Yuliarto S., Zaaqoq A., Zabbe M., Zacharowski K., Zahid M., Zahran M., Zaidan N. Z. B., Zambon M., Zambrano M., Zanella A., Zawadka K., Zaynah N., Zayyad H., Zoufaly A., and Zucman D.
- Published
- 2021
13. Undiagnosed comorbidities among individuals hospitalised with COVID-19 in South African public hospitals
- Author
-
Ismail, F, Blumberg, L, Cohen, C, Potgieter, S, Black, J, Parker, A, Sayed, B, Singh, S, Mvusi, L, Jassat, W, Moultrie, H, Groome, M J, Arendse, T, Masha, M, Dryden, M, Vika, C, and Mudara, C
- Subjects
Glycated Hemoglobin ,Hospitals, Public ,COVID-19 ,HIV Infections ,General Medicine ,South Africa ,Hypertension ,Diabetes Mellitus ,Prevalence ,Humans ,Tuberculosis ,Obesity ,Noncommunicable Diseases ,Pandemics - Abstract
Background. Previous studies have reported comorbid disease, including hypertension, diabetes mellitus, chronic cardiac and renal disease, malignancy, HIV, tuberculosis (TB) and obesity, to be associated with COVID‑19 mortality. National demographic surveys have reported a high proportion of undiagnosed and untreated comorbid disease in South Africa (SA).Objectives. To determine the number of individuals with previously undiagnosed HIV, TB and non-communicable diseases (NCDs) among patients hospitalised with COVID‑19, and the level of medical control of these chronic diseases.Methods. We conducted a sentinel surveillance study to collect enhanced data on HIV, TB and NCDs among individuals with COVID‑19 admitted to 16 secondary-level public hospitals in six of the nine provinces of SA. Trained surveillance officers approached all patients who met the surveillance case definition for inclusion in the study, and consenting patients were enrolled. The data collection instrument included questions on past medical history to determine the self-reported presence of comorbidities. The results of clinical and laboratory testing introduced as part of routine clinical care for hospitalised COVID‑19 patients were collected for the study, to objectively determine the presence of hypertension, diabetes, HIV and TB and the levels of control of diabetes and HIV.Results. On self-reported history, the most prevalent comorbidities were hypertension (n=1 658; 51.5%), diabetes (n=855; 26.6%) and HIV (n=603; 18.7%). The prevalence of self-reported active TB was 3.1%, and that of previous TB 5.5%. There were 1 254 patients admitted with COVID‑19 (39.0%) who met the body mass index criteria for obesity. On clinical and laboratory testing, 87 patients were newly diagnosed with HIV, 29 with TB, 215 with diabetes and 40 with hypertension during their COVID‑19 admission. There were 151/521 patients living with HIV (29.0%) with a viral load >1 000 copies/mL and 309/570 (54.2%) with a CD4 count
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- 2022
14. Undiagnosed comorbidities among individuals hospitalised with COVID-19 in South African public hospitals
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Jassat, W, primary, Mudara, C, additional, Vika, C, additional, Dryden, M, additional, Masha, M, additional, Arendse, T, additional, Groome, MJ, additional, Moultrie, H, additional, Ismail, F, additional, Mvusi, L, additional, Singh, S, additional, Sayed, B, additional, Parker, A, additional, Black, J, additional, Potgieter, S, additional, Cohen, C, additional, and Blumberg, L, additional
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- 2022
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15. Estimating disease severity of Omicron and Delta SARS-CoV-2 infections COMMENT
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Sigal, A., Milo, R., and Jassat, W.
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- 2022
16. Outcomes of laboratory-confirmed SARS-CoV-2 infection in the Omicron-driven fourth wave compared with previous waves in the Western Cape Province, South Africa
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Davies, M-A, Kassanjee, R, Rosseau, P, Morden, E, Johnson, L, Solomon, W, Hsiao, N-Y, Hussey, H, Meintjes, G, Paleker, M, Jacobs, T, Raubenheimer, P, Heekes, A, Dane, P, Bam, J-L, Smith, M, Preiser, W, Pienaar, D, Mendelson, M, Naude, J, Schrueder, N, Mnguni, A, Roux, SL, Murie, K, Prozesky, H, Mahomed, H, Rossouw, L, Wasserman, S, Maughan, D, Boloko, L, Smith, B, Taljaard, J, Symons, G, Ntusi, N, Parker, A, Wolter, N, Jassat, W, Cohen, C, Lessells, R, Wilkinson, RJ, Arendse, J, Kariem, S, Moodley, M, Vallabhjee, K, Wolmarans, M, Cloete, K, Boulle, A, and Wellcome Trust
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Model organisms ,Adult ,Male ,sub-Saharan Africa ,2ND WAVES ,COVID-19 Vaccines ,Omicron ,Immunology ,VARIANT ,Infectious Disease ,1ST ,Article ,1117 Public Health and Health Services ,Cohort Studies ,South Africa ,Young Adult ,COVID-19 Testing ,Seroepidemiologic Studies ,Tropical Medicine ,Humans ,prior infection ,Public, Environmental & Occupational Health ,Human Biology & Physiology ,Science & Technology ,Clinical Laboratory Techniques ,SARS-CoV-2 ,FOS: Clinical medicine ,Public Health, Environmental and Occupational Health ,COVID-19 ,vaccination ,immunity ,Infectious Diseases ,Delta ,Western Cape and South African National Departments of Health in collaboration with the National Institute for Communicable Diseases in South Africa Affiliations ,Parasitology ,Female ,Life Sciences & Biomedicine - Abstract
Objectives: We aimed to compare COVID-19 outcomes in the Omicron-driven fourth wave with prior waves in the Western Cape, the contribution of undiagnosed prior infection to differences in outcomes in a context of high seroprevalence due to prior infection, and whether protection against severe disease conferred by prior infection and/or vaccination was maintained. Methods: In this cohort study, we included public sector patients aged ≥20 years with a laboratory confirmed COVID-19 diagnosis between 14 November-11 December 2021 (wave four) and equivalent prior wave periods. We compared the risk between waves of the following outcomes using Cox regression: death, severe hospitalization or death and any hospitalization or death (all ≤14 days after diagnosis) adjusted for age, sex, comorbidities, geography, vaccination and prior infection. Results: We included 5,144 patients from wave four and 11,609 from prior waves. Risk of all outcomes was lower in wave four compared to the Delta-driven wave three (adjusted Hazard Ratio (aHR) [95% confidence interval (CI)] for death 0.27 [0.19; 0.38]. Risk reduction was lower when adjusting for vaccination and prior diagnosed infection (aHR:0.41, 95% CI: 0.29; 0.59) and reduced further when accounting for unascertained prior infections (aHR: 0.72). Vaccine protection was maintained in wave four (aHR for outcome of death: 0.24; 95% CI: 0.10; 0.58). Conclusions: In the Omicron-driven wave, severe COVID-19 outcomes were reduced mostly due to protection conferred by prior infection and/or vaccination, but intrinsically reduced virulence may account for an approximately 25% reduced risk of severe hospitalization or death compared to Delta.
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- 2022
17. An international observational study to assess the impact of the Omicron variant emergence on the clinical epidemiology of COVID-19 in hospitalised patients
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Goncalves, BP, Hall, M, Jassat, W, Balan, V, Murthy, S, Kartsonaki, C, Semple, MG, Rojek, A, Baruch, J, Reyes, LF, Dasgupta, A, Dunning, J, Citarella, BW, Pritchard, M, Martin-Quiros, A, Sili, U, Baillie, JK, Aryal, D, Arabi, Y, Rashan, A, Angheben, A, Caoili, J, Carrier, FM, Harrison, EM, Gomez-Junyent, J, Figueiredo-Mello, C, Douglas, JJ, Nor, MBM, Chow, YP, Wong, XC, Bertagnolio, S, Thwin, SS, Streinu-Cercel, A, Salazar, L, Rishu, A, Rangappa, R, Ong, DSY, Hashmi, M, Carson, G, Diaz, J, Fowler, R, Kraemer, MUG, Wils, E-J, Horby, P, Merson, L, Olliaro, PL, Goncalves, BP, Hall, M, Jassat, W, Balan, V, Murthy, S, Kartsonaki, C, Semple, MG, Rojek, A, Baruch, J, Reyes, LF, Dasgupta, A, Dunning, J, Citarella, BW, Pritchard, M, Martin-Quiros, A, Sili, U, Baillie, JK, Aryal, D, Arabi, Y, Rashan, A, Angheben, A, Caoili, J, Carrier, FM, Harrison, EM, Gomez-Junyent, J, Figueiredo-Mello, C, Douglas, JJ, Nor, MBM, Chow, YP, Wong, XC, Bertagnolio, S, Thwin, SS, Streinu-Cercel, A, Salazar, L, Rishu, A, Rangappa, R, Ong, DSY, Hashmi, M, Carson, G, Diaz, J, Fowler, R, Kraemer, MUG, Wils, E-J, Horby, P, Merson, L, and Olliaro, PL
- Abstract
BACKGROUND: Whilst timely clinical characterisation of infections caused by novel SARS-CoV-2 variants is necessary for evidence-based policy response, individual-level data on infecting variants are typically only available for a minority of patients and settings. METHODS: Here, we propose an innovative approach to study changes in COVID-19 hospital presentation and outcomes after the Omicron variant emergence using publicly available population-level data on variant relative frequency to infer SARS-CoV-2 variants likely responsible for clinical cases. We apply this method to data collected by a large international clinical consortium before and after the emergence of the Omicron variant in different countries. RESULTS: Our analysis, that includes more than 100,000 patients from 28 countries, suggests that in many settings patients hospitalised with Omicron variant infection less often presented with commonly reported symptoms compared to patients infected with pre-Omicron variants. Patients with COVID-19 admitted to hospital after Omicron variant emergence had lower mortality compared to patients admitted during the period when Omicron variant was responsible for only a minority of infections (odds ratio in a mixed-effects logistic regression adjusted for likely confounders, 0.67 [95% confidence interval 0.61-0.75]). Qualitatively similar findings were observed in sensitivity analyses with different assumptions on population-level Omicron variant relative frequencies, and in analyses using available individual-level data on infecting variant for a subset of the study population. CONCLUSIONS: Although clinical studies with matching viral genomic information should remain a priority, our approach combining publicly available data on variant frequency and a multi-country clinical characterisation dataset with more than 100,000 records allowed analysis of data from a wide range of settings and novel insights on real-world heterogeneity of COVID-19 presentation and clin
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- 2022
18. Paediatric COVID-19 mortality: a database analysis of the impact of health resource disparity
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Marwali, EM, Kekalih, A, Yuliarto, S, Wati, DK, Rayhan, M, Valerie, IC, Cho, HJ, Jassat, W, Blumberg, L, Masha, M, Semple, C, Swann, O, Vasconcelos, MK, Popielska, J, Murthy, S, Fowler, RA, Guerguerian, A-M, Streinu-Cercel, A, Pathmanathan, MD, Rojek, A, Kartsonaki, C, Goncalves, BP, Citarella, BW, Merson, L, Olliaro, PL, Dalton, HJ, Marwali, EM, Kekalih, A, Yuliarto, S, Wati, DK, Rayhan, M, Valerie, IC, Cho, HJ, Jassat, W, Blumberg, L, Masha, M, Semple, C, Swann, O, Vasconcelos, MK, Popielska, J, Murthy, S, Fowler, RA, Guerguerian, A-M, Streinu-Cercel, A, Pathmanathan, MD, Rojek, A, Kartsonaki, C, Goncalves, BP, Citarella, BW, Merson, L, Olliaro, PL, and Dalton, HJ
- Abstract
BACKGROUND: The impact of the COVID-19 pandemic on paediatric populations varied between high-income countries (HICs) versus low-income to middle-income countries (LMICs). We sought to investigate differences in paediatric clinical outcomes and identify factors contributing to disparity between countries. METHODS: The International Severe Acute Respiratory and Emerging Infections Consortium (ISARIC) COVID-19 database was queried to include children under 19 years of age admitted to hospital from January 2020 to April 2021 with suspected or confirmed COVID-19 diagnosis. Univariate and multivariable analysis of contributing factors for mortality were assessed by country group (HICs vs LMICs) as defined by the World Bank criteria. RESULTS: A total of 12 860 children (3819 from 21 HICs and 9041 from 15 LMICs) participated in this study. Of these, 8961 were laboratory-confirmed and 3899 suspected COVID-19 cases. About 52% of LMICs children were black, and more than 40% were infants and adolescent. Overall in-hospital mortality rate (95% CI) was 3.3% [=(3.0% to 3.6%), higher in LMICs than HICs (4.0% (3.6% to 4.4%) and 1.7% (1.3% to 2.1%), respectively). There were significant differences between country income groups in intervention profile, with higher use of antibiotics, antivirals, corticosteroids, prone positioning, high flow nasal cannula, non-invasive and invasive mechanical ventilation in HICs. Out of the 439 mechanically ventilated children, mortality occurred in 106 (24.1%) subjects, which was higher in LMICs than HICs (89 (43.6%) vs 17 (7.2%) respectively). Pre-existing infectious comorbidities (tuberculosis and HIV) and some complications (bacterial pneumonia, acute respiratory distress syndrome and myocarditis) were significantly higher in LMICs compared with HICs. On multivariable analysis, LMIC as country income group was associated with increased risk of mortality (adjusted HR 4.73 (3.16 to 7.10)). CONCLUSION: Mortality and morbidities were higher in LMICs
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- 2022
19. Sentinel seroprevalence of SARS-CoV-2 in Gauteng Province, South Africa, August - October 2020
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George, J A, primary, Khoza, S, additional, Mayne, E, additional, Dlamini, S, additional, Kone, N, additional, Jassat, W, additional, Chetty, K, additional, Centner, C M, additional, Pillay, T, additional, Maphayi, M, additional, Mabuza, D, additional, Maposa, I, additional, and Cassim, N, additional
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- 2021
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20. Understanding the differential impacts of COVID-19 among hospitalised patients in South Africa for equitable response
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Phaswana-Mafuya, N, primary, Shisana, O, additional, Jassat, W, additional, Baral, S D, additional, Makofane, Keletso, additional, Phalane, E, additional, Zuma, Khangelani, additional, Zungu, N, additional, and Chadyiwa, Martha, additional
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- 2021
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21. A call to action: Temporal trends of COVID-19 deaths in the South African Muslim community
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Omar, M A K, primary, Jassat, W, additional, Brey, Z, additional, Parker, S, additional, Wadee, M, additional, Wadee, S, additional, and Madhi, S A, additional
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- 2021
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22. A call to action: Temporal trends of COVID-19 deaths in the South African Muslim community
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Jassat, W, primary, Brey, Z, additional, Parker, S, additional, Wadee, M, additional, Wadee, S, additional, and Madhi, S A, additional
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- 2021
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23. COVID-19 in long-term care facilities in South Africa: No time for complacency
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Cowper, B, primary, Jassat, W, additional, Pretorius, P, additional, Geffen, L, additional, Legodu, C, additional, Singh, S, additional, and Blumberg, L, additional
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- 2020
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24. The COVID-19 crisis in South Africa: Protecting the vulnerable
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Blumberg, L, primary, Jassat, W, additional, Mendelson, M, additional, and Cohen, C, additional
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- 2020
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25. Drug-resistant tuberculosis patient care journeys in South Africa: a pilot study using routine laboratory data
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Hill, J., primary, Dickson-Hall, L., additional, Grant, A. D., additional, Grundy, C., additional, Black, J., additional, Kielmann, K., additional, Mlisana, K., additional, Mitrani, L., additional, Loveday, M., additional, Moshabela, M., additional, Le Roux, S., additional, Jassat, W., additional, Nicol, M., additional, and Cox, H., additional
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- 2020
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26. Guiding equitable prioritisation of COVID-19 vaccine distribution and strategic deployment in South Africa to enhance effectiveness and access to vulnerable communities and prevent waste.
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Ovens, W., Tomescu, S., Harrison, E., Crompton, T., de Nooy, A., Jassat, W., Banoo, S., Pisa, P., and Sanne, I.
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- 2022
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27. PEDIATRIC COVID-19 MORTALITY: TWO-SIDED CHALLENGES FROM HEALTH RESOURCE DISPARITY.
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Marwali, E. M., Kekalih, A., Yuliarto, S., Wati, D. K., Rayhan, M., Valerie, I. C., Cho, H. J., Jassat, W., Blumberg, L., Masha, M., Semple, M. G., Swann, O. V., Popielska, J., Murthy, S., Fowler, R., Guerguerian, A. M., Cercel, A. S., Pathmanathan, M. D., Citarella, B., and Rojek, A.
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- 2022
28. Strengthening the Delivery and Improving Outcomes of Drug-Resistant TB Treatment through Rational Medication Use Review
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Njeka N, Jassat W, Maranga A, and Fomundam H
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medicine.medical_specialty ,Tuberculosis ,Descriptive statistics ,business.industry ,Missed Dose ,Drug resistance ,medicine.disease ,Patient safety ,Regimen ,Pharmacotherapy ,Emergency medicine ,Health care ,medicine ,business - Abstract
Introduction: A Rational Medication Use Review was conducted in health facilities in five high burden provinces (KwaZulu Natal, Western Cape, Eastern Cape, Gauteng and North West) that account for 77% of MDR-TB cases and 92% of XDR-TB in South Africa. Methodology: A purposive sampling of health facilities was done and stratified to represent different models of DR-TB service providers including centralized sites, decentralized sites, and satellite sites. Records for review were selected randomly among patients who initiated treatment between October 2011 and December 2012 and descriptive analysis conducted. Results: The review involved 139 patients (76.3% MDR-TB and 17.3% XDR-TB). 76.3% of them had a pretreatment DST and this was used for regimen selection. Renal function monitoring for dose adjustment was poor although baseline serum creatinine values were available on record for 69.1% of the patients. There was a high degree of missed doses with 66.7% of the patients having at least one missed dose. Co-morbid conditions were common with 66.2%, 13.0% and 5.8% of the patents with HIV, hypertension and seizure disorders respectively. Only 30.2% of the MDR-TB patents and 50% of the XDR-TB patients had been assessed for adverse drug reactions during the intensive phase although 125 episodes of ADRs were on record. Serum creatinine monitoring was not consistent (only 22.3% of patients had monthly values) although 16.1% of the patients had levels that would have required dose adjustments that were not done. Conclusion: There are many factors related to the patient, drug therapy, health care providers, and the health system that may adversely influence DR-TB treatment outcomes and patient safety. These can be detected early through regular rational medication use review and institutionalization of the process. This however requires a multidisciplinary approach with involvement of levels of the health system and various institutions involved TB in medication use.
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- 2018
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29. Acute mental health care according to recent mental health legislation Part II. Activity-based costing
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Janse van Rensburg, ABR, primary and Jassat, W, additional
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- 2011
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30. The value of open-source clinical science in pandemic response
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Ali Abbas, Sheryl Ann Abdukahil, Nurul Najmee Abdulkadir, Ryuzo Abe, Laurent Abel, Lara Absil, Subhash Acharya, Andrew Acker, Shingo Adachi, Elisabeth Adam, Diana Adrião, Saleh Al Ageel, Shakeel Ahmed, Quratul Ain, Kate Ainscough, Tharwat Aisa, Ali Ait Hssain, Younes Ait Tamlihat, Takako Akimoto, Ernita Akmal, Eman Al Qasim, Razi Alalqam, Tanvir Alam, Tala Al-dabbous, Senthilkumar Alegesan, Cynthia Alegre, Marta Alessi, Beatrice Alex, Kévin Alexandre, Abdulrahman Al-Fares, Huda Alfoudri, Imran Ali, Naseem Ali Shah, Kazali Enagnon Alidjnou, Jeffrey Aliudin, Qabas Alkhafajee, Clotilde Allavena, Nathalie Allou, Aneela Altaf, João Alves, João Melo Alves, Rita Alves, Maria Amaral, Nur Amira, Heidi Ammerlaan, Phoebe Ampaw, Roberto Andini, Claire Andrejak, Andrea Angheben, François Angoulvant, Séverine Ansart, Sivanesen Anthonidass, Massimo Antonelli, Carlos Alexandre Antunes de Brito, Kazi Rubayet Anwar, Ardiyan Apriyana, Yaseen Arabi, Irene Aragao, Rajeshwari Arali, Francisco Arancibia, Carolline Araujo, Antonio Arcadipane, Patrick Archambault, Lukas Arenz, Jean-Benoît Arlet, Christel Arnold-Day, Ana Aroca, Lovkesh Arora, Rakesh Arora, Elise Artaud-Macari, Diptesh Aryal, Motohiro Asaki, Angel Asensio, Elizabeth Ashley, Muhammad Ashraf, Sheharyar Ashraf, Mohammad Asim, Jean Baptiste Assie, Amirul Asyraf, Anika Atique, AM Udara Lakshan Attanyake, Johann Auchabie, Hugues Aumaitre, Adrien Auvet, Laurène Azemar, Cecile Azoulay, Benjamin Bach, Delphine Bachelet, Claudine Badr, Nadia Baig, J. Kenneth Baillie, J Kevin Baird, Erica Bak, Agamemnon Bakakos, Nazreen Abu Bakar, Andriy Bal, Mohanaprasanth Balakrishnan, Valeria Balan, Firouzé Bani-Sadr, Renata Barbalho, Nicholas Yuri Barbosa, Wendy S. Barclay, Saef Umar Barnett, Michaela Barnikel, Helena Barrasa, Audrey Barrelet, Cleide Barrigoto, Marie Bartoli, Cheryl Bartone, Joaquín Baruch, Mustehan Bashir, Romain Basmaci, Muhammad Fadhli Hassin Basri, Diego Bastos, Denise Battaglini, Jules Bauer, Diego Fernando Bautista Rincon, Denisse Bazan Dow, Alexandra Bedossa, Ker Hong Bee, Sylvie Behilill, Albertus Beishuizen, Aleksandr Beljantsev, David Bellemare, Anna Beltrame, Beatriz Amorim Beltrão, Marine Beluze, Nicolas Benech, Lionel Eric Benjiman, Dehbia Benkerrou, Suzanne Bennett, Luís Bento, Jan-Erik Berdal, Delphine Bergeaud, Hazel Bergin, José Luis Bernal Sobrino, Giulia Bertoli, Lorenzo Bertolino, Simon Bessis, Adam Betz, Sybille Bevilcaqua, Karine Bezulier, Amar Bhatt, Krishna Bhavsar, Isabella Bianchi, Claudia Bianco, Farah Nadiah Bidin, Moirangthem Bikram Singh, Felwa Bin Humaid, Mohd Nazlin Bin Kamarudin, François Bissuel, Patrick Biston, Laurent Bitker, Pablo Blanco-Schweizer, Catherine Blier, Frank Bloos, Mathieu Blot, Lucille Blumberg, Filomena Boccia, Laetitia Bodenes, Alice Bogaarts, Debby Bogaert, Anne-Hélène Boivin, Pierre-Adrien Bolze, François Bompart, Aurelius Bonfasius, Diogo Borges, Raphaël Borie, Hans Martin Bosse, Elisabeth Botelho-Nevers, Lila Bouadma, Olivier Bouchaud, Sabelline Bouchez, Dounia Bouhmani, Damien Bouhour, Kévin Bouiller, Laurence Bouillet, Camile Bouisse, Anne-Sophie Boureau, John Bourke, Maude Bouscambert, Aurore Bousquet, Jason Bouziotis, Bianca Boxma, Marielle Boyer-Besseyre, Maria Boylan, Fernando Augusto Bozza, Matthew Brack, Axelle Braconnier, Cynthia Braga, Timo Brandenburger, Filipa Brás Monteiro, Luca Brazzi, Dorothy Breen, Patrick Breen, Stephen Brett, Kathy Brickell, Tessa Broadley, Alex Browne, Shaunagh Browne, Nicolas Brozzi, Marjolein Brusse-Keizer, Nina Buchtele, Christian Buesaquillo, Polina Bugaeva, Marielle Buisson, Erlina Burhan, Aidan Burrell, Ingrid G. Bustos, Denis Butnaru, André Cabie, Susana Cabral, Eder Caceres, Cyril Cadoz, Mia Callahan, Kate Calligy, Jose Andres Calvache, João Cam, Valentine Campana, Paul Campbell, Josie Campisi, Cecilia Canepa, Mireia Cantero, Pauline Caraux-Paz, Sheila Cárcel, Chiara Simona Cardellino, Filipa Cardoso, Filipe Cardoso, Nelson Cardoso, Sofia Cardoso, Simone Carelli, Nicolas Carlier, Thierry Carmoi, Gayle Carney, Chloe Carpenter, Inês Carqueja, Marie-Christine Carret, François Martin Carrier, Ida Carroll, Gail Carson, Ed Carton, Maire-Laure Casanova, Mariana Cascão, Siobhan Casey, José Casimiro, Bailey Cassandra, Silvia Castañeda, Nidyanara Castanheira, Guylaine Castor-Alexandre, Henry Castrillón, Ivo Castro, Ana Catarino, François-Xavier Catherine, Paolo Cattaneo, Roberta Cavalin, Giulio Giovanni Cavalli, Alexandros Cavayas, Adrian Ceccato, Minerva Cervantes-Gonzalez, Anissa Chair, Catherine Chakveatze, Adrienne Chan, Meera Chand, Christelle Chantalat Auger, Jean-Marc Chapplain, Julie Chas, Mobin Chaudary, Jonathan Samuel Chávez Iñiguez, Anjellica Chen, Yih-Sharng Chen, Matthew Pellan Cheng, Antoine Cheret, Thibault Chiarabini, Julian Chica, Suresh Kumar Chidambaram, Leong Chin-Tho, Catherine Chirouze, Davide Chiumello, Hwa Jin Cho, Sung-Min Cho, Bernard Cholley, Marie-Charlotte Chopin, Ting Soo Chow, Yock Ping Chow, Hiu Jian Chua, Jonathan Chua, Jose Pedro Cidade, José Miguel Cisneros Herreros, Barbara Wanjiru Citarella, Anna Ciullo, Emma Clarke, Jennifer Clarke, Rolando Claure Del Granado, Sara Clohisey, J. Perren Cobb, Necsoi Coca, Cassidy Codan, Caitriona Cody, Alexandra Coelho, Megan Coles, Gwenhaël Colin, Michael Collins, Sebastiano Maria Colombo, Pamela Combs, Jennifer Connolly, Marie Connor, Anne Conrad, Sofía Contreras, Elaine Conway, Graham S. Cooke, Mary Copland, Hugues Cordel, Amanda Corley, Sarah Cormican, Sabine Cornelis, Alexander Daniel Cornet, Arianne Joy Corpuz, Andrea Cortegiani, Grégory Corvaisier, Emma Costigan, Camille Couffignal, Sandrine Couffin-Cadiergues, Roxane Courtois, Stéphanie Cousse, Rachel Cregan, Charles Crepy D'Orleans, Sabine Croonen, Gloria Crowl, Jonathan Crump, Claudina Cruz, Juan Luis Cruz Berm, Jaime Cruz Rojo, Marc Csete, Alberto Cucino, Ailbhe Cullen, Caroline Cullen, Matthew Cummings, Gerard Curley, Elodie Curlier, Colleen Curran, Paula Custodio, Ana da Silva Filipe, Charlene Da Silveira, Al-Awwab Dabaliz, Andrew Dagens, Darren Dahly, Heidi Dalton, Jo Dalton, Seamus Daly, Federico D'Amico, Nick Daneman, Corinne Daniel, Emmanuelle A Dankwa, Jorge Dantas, Frédérick D’Aragon, Mark de Boer, Gillian de Loughry, Diego de Mendoza, Etienne De Montmollin, Rafael Freitas de Oliveira França, Ana Isabel de Pinho Oliveira, Rosanna De Rosa, Thushan de Silva, Peter de Vries, Jillian Deacon, David Dean, Alexa Debard, Bianca DeBenedictis, Marie-Pierre Debray, Nathalie DeCastro, William Dechert, Lauren Deconninck, Romain Decours, Eve Defous, Isabelle Delacroix, Eric Delaveuve, Karen Delavigne, Nathalie M. Delfos, Ionna Deligiannis, Andrea Dell'Amore, Christelle Delmas, Pierre Delobel, Corine Delsing, Elisa Demonchy, Emmanuelle Denis, Dominique Deplanque, Pieter Depuydt, Mehul Desai, Diane Descamps, Mathilde Desvallée, Santi Dewayanti, Alpha Diallo, Sylvain Diamantis, André Dias, Priscila Diaz, Rodrigo Diaz, Juan Jose Diaz Diaz, Kévin Didier, Jean-Luc Diehl, Wim Dieperink, Jérôme Dimet, Vincent Dinot, Fara Diop, Alphonsine Diouf, Yael Dishon, Devika Dixit, Félix Djossou, Annemarie B. Docherty, Helen Doherty, Arjen M Dondorp, Andy Dong, Christl A. Donnelly, Maria Donnelly, Chloe Donohue, Sean Donohue, Yoann Donohue, Ciara Doran, Peter Doran, Céline Dorival, Eric D'Ortenzio, James Joshua Douglas, Renee Douma, Nathalie Dournon, Triona Downer, Joanne Downey, Mark Downing, Tom Drake, Aoife Driscoll, Murray Dryden, Claudio Duarte Fonseca, Vincent Dubee, François Dubos, Alexandre Ducancelle, Toni Duculan, Susanne Dudman, Abhijit Duggal, Paul Dunand, Jake Dunning, Mathilde Duplaix, Emanuele Durante-Mangoni, Lucian Durham III, Bertrand Dussol, Juliette Duthoit, Xavier Duval, Anne Margarita Dyrhol-Riise, Sim Choon Ean, Marco Echeverria-Villalobos, Siobhan Egan, Carla Eira, Mohammed El Sanharawi, Subbarao Elapavaluru, Brigitte Elharrar, Jacobien Ellerbroek, Philippine Eloy, Tarek Elshazly, Iqbal Elyazar, Isabelle Enderle, Tomoyuki Endo, Chan Chee Eng, Ilka Engelmann, Vincent Enouf, Olivier Epaulard, Martina Escher, Mariano Esperatti, Hélène Esperou, Marina Esposito-Farese, João Estevão, Manuel Etienne, Nadia Ettalhaoui, Anna Greti Everding, Mirjam Evers, Isabelle Fabre, Marc Fabre, Amna Faheem, Arabella Fahy, Cameron J. 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Turtle, Anders Tveita, Pawel Twardowski, Makoto Uchiyama, PG Ishara Udayanga, Andrew Udy, Roman Ullrich, Zubair Umer, Alberto Uribe, Asad Usman, Cristinava Vajdovics, Luís Val-Flores, Ana Luiza Valle, Amélie Valran, Stijn Van de Velde, Marcel van den Berge, Machteld van der Feltz, Paul van der Valk, Nicky Van Der Vekens, Peter Van der Voort, Sylvie Van Der Werf, Marlice van Dyk, Laura van Gulik, Jarne Van Hattem, Steven van Lelyveld, Carolien van Netten, Gitte Van Twillert, Ilonka van Veen, Noémie Vanel, Henk Vanoverschelde, Pooja Varghese, Michael Varrone, Shoban Raj Vasudayan, Charline Vauchy, Helen Vaughan, Shaminee Veeran, Aurélie Veislinger, Sebastian Vencken, Sara Ventura, Annelies Verbon, José Ernesto Vidal, César Vieira, Deepak Vijayan, Joy Ann Villanueva, Judit Villar, Pierre-Marc Villeneuve, Andrea Villoldo, Nguyen Van Vinh Chau, Benoit Visseaux, Hannah Visser, Chiara Vitiello, Harald Vonkeman, Fanny Vuotto, Noor Hidayu Wahab, Suhaila Abdul Wahab, Nadirah Abdul Wahid, Marina Wainstein, Wan Fadzlina Wan Muhd Shukeri, Chih-Hsien Wang, Steven Anthony Webb, Jia Wei, Katharina Weil, Tan Pei Wen, Sanne Wesselius, T. Eoin West, Murray Wham, Bryan Whelan, Nicole White, Paul Henri Wicky, Aurélie Wiedemann, Surya Otto Wijaya, Keith Wille, Suzette Willems, Virginie Williams, Evert-Jan Wils, Ng Wing Yiu, Calvin Wong, Teck Fung Wong, Xin Ci Wong, Yew Sing Wong, Gan Ee Xian, Lim Saio Xian, Kuan Pei Xuan, Ioannis Xynogalas, Sophie Yacoub, Siti Rohani Binti Mohd Yakop, Masaki Yamazaki, Yazdan Yazdanpanah, Nicholas Yee Liang Hing, Cécile Yelnik, Chian Hui Yeoh, Stephanie Yerkovich, Toshiki Yokoyama, Hodane Yonis, Obada Yousif, Saptadi Yuliarto, Akram Zaaqoq, Marion Zabbe, Kai Zacharowski, Masliza Zahid, Maram Zahran, Nor Zaila Binti Zaidan, Maria Zambon, Miguel Zambrano, Alberto Zanella, Konrad Zawadka, Nurul Zaynah, Hiba Zayyad, Alexander Zoufaly, David Zucman, ESTACA'Lab ( ESTACA'Lab ), École Supérieure des Techniques Aéronautiques et de Construction Automobile (ESTACA), Laboratoire d’Ingénierie Circulation Transport et Éco-gestion des systèmes énergétiques pour les transports (LICIT-Eco7), École Nationale des Travaux Publics de l'État (ENTPE)-Université Gustave Eiffel, St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller University [New York], Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Department of Mathematics and Statistics, Wichita State University, Indo-French Center for Groundwater Research (IFCGR), Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-National Geophysical Research Institute [Hyderabad] (NGRI), National Geophysical Research Institute [Hyderabad] (NGRI), Department of Zoology [Rawalpindi, Pakistan], Pir Mehr Ali Shah Arid Agriculture University = PMAS-Arid Agriculture University Rawalpindi (AAUR), CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand, Génétique Moléculaire des Virus à ARN - Molecular Genetics of RNA Viruses (GMV-ARN (UMR_3569 / U-Pasteur_2)), Institut Pasteur [Paris] (IP)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Centre National de Référence des virus des infections respiratoires (dont la grippe) - National Reference Center Virus Influenzae [Paris] (CNR - laboratoire coordonnateur), Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), Abbas A., Abdukahil S.A., Abdulkadir N.N., Abe R., Abel L., Absil L., Acharya S., Acker A., Adachi S., Adam E., Adriao D., Ageel S.A., Ahmed S., Ain Q., Ainscough K., Aisa T., Ait Hssain A., Ait Tamlihat Y., Akimoto T., Akmal E., Al Qasim E., Alalqam R., Alam T., Al-dabbous T., Alegesan S., Alegre C., Alessi M., Alex B., Alexandre K., Al-Fares A., Alfoudri H., Ali I., Ali Shah N., Alidjnou K.E., Aliudin J., Alkhafajee Q., Allavena C., Allou N., Altaf A., Alves J., Alves J.M., Alves R., Amaral M., Amira N., Ammerlaan H., Ampaw P., Andini R., Andrejak C., Angheben A., Angoulvant F., Ansart S., Anthonidass S., Antonelli M., Antunes de Brito C.A., Anwar K.R., Apriyana A., Arabi Y., Aragao I., Arali R., Arancibia F., Araujo C., Arcadipane A., Archambault P., Arenz L., Arlet J.-B., Arnold-Day C., Aroca A., Arora L., Arora R., Artaud-Macari E., Aryal D., Asaki M., Asensio A., Ashley E., Ashraf M., Ashraf S., Asim M., Assie J.B., Asyraf A., Atique A., Attanyake A.U.L., Auchabie J., Aumaitre H., Auvet A., Azemar L., Azoulay C., Bach B., Bachelet D., Badr C., Baig N., Baillie J.K., Baird J.K., Bak E., Bakakos A., Bakar N.A., Bal A., Balakrishnan M., Balan V., Bani-Sadr F., Barbalho R., Barbosa N.Y., Barclay W.S., Barnett S.U., Barnikel M., Barrasa H., Barrelet A., Barrigoto C., Bartoli M., Bartone C., Baruch J., Bashir M., Basmaci R., Basri M.F.H., Bastos D., Battaglini D., Bauer J., Bautista Rincon D.F., Bazan Dow D., Bedossa A., Bee K.H., Behilill S., Beishuizen A., Beljantsev A., Bellemare D., Beltrame A., Beltrao B.A., Beluze M., Benech N., Benjiman L.E., Benkerrou D., Bennett S., Bento L., Berdal J.-E., Bergeaud D., Bergin H., Bernal Sobrino J.L., Bertoli G., Bertolino L., Bessis S., Betz A., Bevilcaqua S., Bezulier K., Bhatt A., Bhavsar K., Bianchi I., Bianco C., Bidin F.N., Bikram Singh M., Bin Humaid F., Bin Kamarudin M.N., Bissuel F., Biston P., Bitker L., Blanco-Schweizer P., Blier C., Bloos F., Blot M., Blumberg L., Boccia F., Bodenes L., Bogaarts A., Bogaert D., Boivin A.-H., Bolze P.-A., Bompart F., Bonfasius A., Borges D., Borie R., Bosse H.M., Botelho-Nevers E., Bouadma L., Bouchaud O., Bouchez S., Bouhmani D., Bouhour D., Bouiller K., Bouillet L., Bouisse C., Boureau A.-S., Bourke J., Bouscambert M., Bousquet A., Bouziotis J., Boxma B., Boyer-Besseyre M., Boylan M., Bozza F.A., Brack M., Braconnier A., Braga C., Brandenburger T., Bras Monteiro F., Brazzi L., Breen D., Breen P., Brett S., Brickell K., Broadley T., Browne A., Browne S., Brozzi N., Brusse-Keizer M., Buchtele N., Buesaquillo C., Bugaeva P., Buisson M., Burhan E., Burrell A., Bustos I.G., Butnaru D., Cabie A., Cabral S., Caceres E., Cadoz C., Callahan M., Calligy K., Calvache J.A., Cam J., Campana V., Campbell P., Campisi J., Canepa C., Cantero M., Caraux-Paz P., Carcel S., Cardellino C.S., Cardoso F., Cardoso N., Cardoso S., Carelli S., Carlier N., Carmoi T., Carney G., Carpenter C., Carqueja I., Carret M.-C., Carrier F.M., Carroll I., Carson G., Carton E., Casanova M.-L., Cascao M., Casey S., Casimiro J., Cassandra B., Castaneda S., Castanheira N., Castor-Alexandre G., Castrillon H., Castro I., Catarino A., Catherine F.-X., Cattaneo P., Cavalin R., Cavalli G.G., Cavayas A., Ceccato A., Cervantes-Gonzalez M., Chair A., Chakveatze C., Chan A., Chand M., Chantalat Auger C., Chapplain J.-M., Chas J., Chaudary M., Chavez Iniguez J.S., Chen A., Chen Y.-S., Cheng M.P., Cheret A., Chiarabini T., Chica J., Chidambaram S.K., Chin-Tho L., Chirouze C., Chiumello D., Cho H.J., Cho S.-M., Cholley B., Chopin M.-C., Chow T.S., Chow Y.P., Chua H.J., Chua J., Cidade J.P., Cisneros Herreros J.M., Citarella B.W., Ciullo A., Clarke E., Clarke J., Claure Del Granado R., Clohisey S., Cobb J.P., Coca N., Codan C., Cody C., Coelho A., Coles M., Colin G., Collins M., Colombo S.M., Combs P., Connolly J., Connor M., Conrad A., Contreras S., Conway E., Cooke G.S., Copland M., Cordel H., Corley A., Cormican S., Cornelis S., Cornet A.D., Corpuz A.J., Cortegiani A., Corvaisier G., Costigan E., Couffignal C., Couffin-Cadiergues S., Courtois R., Cousse S., Cregan R., Crepy D'Orleans C., Croonen S., Crowl G., Crump J., Cruz C., Cruz Berm J.L., Cruz Rojo J., Csete M., Cucino A., Cullen A., Cullen C., Cummings M., Curley G., Curlier E., Curran C., Custodio P., da Silva Filipe A., Da Silveira C., Dabaliz A.-A., Dagens A., Dahly D., Dalton H., Dalton J., Daly S., D'Amico F., Daneman N., Daniel C., Dankwa E.A., Dantas J., D'Aragon F., de Boer M., de Loughry G., de Mendoza D., De Montmollin E., de Oliveira Franca R.F., de Pinho Oliveira A.I., De Rosa R., de Silva T., de Vries P., Deacon J., Dean D., Debard A., DeBenedictis B., Debray M.-P., DeCastro N., Dechert W., Deconninck L., Decours R., Defous E., Delacroix I., Delaveuve E., Delavigne K., Delfos N.M., Deligiannis I., Dell'Amore A., Delmas C., Delobel P., Delsing C., Demonchy E., Denis E., Deplanque D., Depuydt P., Desai M., Descamps D., Desvallee M., Dewayanti S., Diallo A., Diamantis S., Dias A., Diaz P., Diaz R., Diaz Diaz J.J., Didier K., Diehl J.-L., Dieperink W., Dimet J., Dinot V., Diop F., Diouf A., Dishon Y., Dixit D., Djossou F., Docherty A.B., Doherty H., Dondorp A.M., Dong A., Donnelly C.A., Donnelly M., Donohue C., Donohue S., Donohue Y., Doran C., Doran P., Dorival C., D'Ortenzio E., Douglas J.J., Douma R., Dournon N., Downer T., Downey J., Downing M., Drake T., Driscoll A., Dryden M., Duarte Fonseca C., Dubee V., Dubos F., Ducancelle A., Duculan T., Dudman S., Duggal A., Dunand P., Dunning J., Duplaix M., Durante-Mangoni E., Durham III L., Dussol B., Duthoit J., Duval X., Dyrhol-Riise A.M., Ean S.C., Echeverria-Villalobos M., Egan S., Eira C., El Sanharawi M., Elapavaluru S., Elharrar B., Ellerbroek J., Eloy P., Elshazly T., Elyazar I., Enderle I., Endo T., Eng C.C., Engelmann I., Enouf V., Epaulard O., Escher M., Esperatti M., Esperou H., Esposito-Farese M., Estevao J., Etienne M., Ettalhaoui N., Everding A.G., Evers M., Fabre I., Fabre M., Faheem A., Fahy A., Fairfield C.J., Fakar Z., Faria P., Farooq A., Farrar J.J., Farshait N., Fateena H., Fatoni A.Z., Faure K., Favory R., Fayed M., Feely N., Feeney L., Fernandes J., Fernandes M., Fernandes S., Ferrand F.-X., Ferrand Devouge E., Ferrao J., Ferraz M., Ferreira B., Ferreira S., Ferrer-Roca R., Ferriere N., Ficko C., Figueiredo-Mello C., Fiorda J., Flament T., Flateau C., Fletcher T., Florio L.L., Flynn B., Flynn D., Foley C., Foley J., Fomin V., Fonseca T., Fontela P., Forsyth S., Foster D., Foti G., Fourn E., Fowler R.A., Fraher D.M., Franch-Llasat D., Fraser C., Fraser J.F., Freire M.V., Freitas Ribeiro A., Friedrich C., Fritz R., Fry S., Fuentes N., Fukuda M., Gaborieau V., Gaci R., Gagliardi M., Gagnard J.-C., Gagne N., Gagneux-Brunon A., Gaiao S., Gail Skeie L., Gallagher P., Gallego Curto E., Gamble C., Gani Y., Garan A., Garcia R., Garcia Barrio N., Garcia-Diaz J., Garcia-Gallo E., Garimella N., Garot D., Garrait V., Gauli B., Gault N., Gavin A., Gavrylov A., Gaymard A., Gebauer J., Geraud E., Gerbaud Morlaes L., Germano N., ghisulal P.K., Ghosn J., Giani M., Giaquinto C., Gibson J., Gigante T., Gilg M., Gilroy E., Giordano G., Girvan M., Gissot V., Gitahi J., Giwangkancana G., Glikman D., Glybochko P., Gnall E., Goco G., Goehringer F., Goepel S., Goffard J.-C., Goh J.Y., Golob J., Gomes R., Gomez K., Gomez-Junyent J., Gominet M., Gonzalez A., Gordon P., Gordon A., Gorenne I., Goubert L., Goujard C., Goulenok T., Grable M., Graf J., Grandin E.W., Granier P., Grasselli G., Grazioli L., Green C.A., Greene C., Greenhalf W., Greffe S., Grieco D.L., Griffee M., Griffiths F., Grigoras I., Groenendijk A., Grosse Lordemann A., Gruner H., Gu Y., Guarracino F., Guedj J., Guego M., Guellec D., Guerguerian A.-M., Guerreiro D., Guery R., Guillaumot A., Guilleminault L., Guimaraes de Castro M., Guimard T., Haalboom M., Haber D., Habraken H., Hachemi A., Hadri N., Haidash O., Haider S., Haidri F., Hakak S., Hall A., Hall M., Halpin S., Hamer A., Hamers R., Hamidfar R., Hammond T., Han L.Y., Haniffa R., Hao K.W., Hardwick H., Harrison E.M., Harrison J., Harrison S.B.E., Hartman A., Hashmi J., Hashmi M., Hayat M., Hayes A., Hays L., Heerman J., Heggelund L., Hendry R., Hennessy M., Henriquez A., Hentzien M., Herekar F., Hernandez-Montfort J., Herr D., Hershey A., Hesstvedt L., Hidayah A., Higgins D., Higgins E., HigginsOKeeffe G., Hinchion R., Hinton S., Hiraiwa H., Hitoto H., Ho A., Ho Y.B., Hoctin A., Hoffmann I., Hoh W.H., Hoiting O., Holt R., Holter J.C., Horby P., Horcajada J.P., Hoshino K., Houas I., Hough C.L., Houltham S., Hsu J.M.-Y., Hulot J.-S., Hussain I., Ijaz S., Illes H.-G., Imbert P., Imran M., Imran Sikander R., Inacio H., Infante Dominguez C., Ing Y.S., Iosifidis E., Ippolito M., Isgett S., Ishani P.G.P.I., Isidoro T., Ismail N., Isnard M., Itai J., Ito A., Ivulich D., Jaafar D., Jaafoura S., Jabot J., Jackson C., Jamieson N., Jaquet P., Jassat W., Jaud-Fischer C., Jaureguiberry S., Javidfar J., Jawad I., Jaworsky D., Jayakumar D., Jego F., Jelani A.M., Jenum S., Jimbo-Sotomayor R., Job V.D.P., Joe O.Y., Jorge Garcia R.N., Joseph C., Joseph M., Joshi S., Jourdain M., Jouvet P., June J., Jung A., Jung H., Juzar D., Kafif O., Kaguelidou F., Kaisbain N., Kaleesvran T., Kali S., Kalicinska A., Kalomoiri S., Kamal S., Kamaluddin M.A.A., Kamaruddin Z.A.C., Kamarudin N., Kandamby D.H., Kandel C., Kang K.Y., Kant R., Kanwal D., Kanyawati D., Karki B., Karpayah P., Karsies T., Kartsonaki C., Kasugai D., Kataria A., Katz K., Kaur A., Kaur Johal S., Kawasaki T., Kay C., Keane H., Keating S., Kellam P., Kelly A., Kelly C., Kelly N., Kelly S., Kelly Y., Kelsey M., Kennedy R., Kennon K., Kernan M., Kerroumi Y., Keshav S., Kestelyn E., Khalid I., Khalid O., Khalil A., Khan C., Khan I., Khanal S., Kho M.E., Khoo D., Khoo R., Khoo S., Khoso N., Kiat K.H., Kida Y., Kiiza P., Kildal A.B., Kim J.B., Kimmoun A., Kindgen-Milles D., King A., Kitamura N., Klenerman P., Klont R., Kloumann Bekken G., Knight S., Kobbe R., Kodippily C., Kohns Vasconcelos M., Koirala S., Komatsu M., Korten V., Kosgei C., Kpangon A., Krawczyk K., Krishnan S., Krishnan V., Kruglova O., Kumar A., Kumar D., Kumar G., Kumar M., Kumar Vecham P., Kuriakose D., Kurtzman E., Kusumastuti N.P., Kutsogiannis D., Kutsyna G., Kyriakoulis K., Lachatre M., Lacoste M., Laffey J.G., Lagrange M., Laine F., Lairez O., Lakhey S., Lalueza A., Lambert M., Lamontagne F., Langelot-Richard M., Langlois V., Lantang E.Y., Lanza M., Laouenan C., Laribi S., Lariviere D., Lasry S., Latif N., Launay O., Laureillard D., Lavie-Badie Y., Law A., Lawrence C., Lawrence T., Le M., Le Bihan C., Le Bris C., Le Falher G., Le Fevre L., Le Hingrat Q., Le Marechal M., Le Mestre S., Le Moal G., Le Moing V., Le Nagard H., Le Turnier P., Leal E., Leal Santos M., Lee B.H., Lee H.G., Lee J., Lee S.H., Lee T.C., Lee Y.L., Leeming G., Lefebvre B., Lefebvre L., Lefevre B., LeGac S., Lelievre J.-D., Lellouche F., Lemaignen A., Lemee V., Lemeur A., Lemmink G., Lene H.S., Lennon J., Leon R., Leone M., Lepiller Q., Lescure F.-X., Lesens O., Lesouhaitier M., Lester-Grant A., Levy B., Levy Y., Levy-Marchal C., Lewandowska K., L'Her E., Li Bassi G., Liang J., Liaquat A., Liegeon G., Lim K.C., Lim W.S., Lima C., Lina B., Lina L., Lind A., Lingas G., Lion-Daolio S., Lissauer S., Liu K., Livrozet M., Lizotte P., Loforte A., Lolong N., Loon L.C., Lopes D., Lopez-Colon D., Loschner A.L., Loubet P., Loufti B., Louis G., Lourenco S., Lovelace-Macon L., Low L.L., Lowik M., Loy J.S., Lucet J.C., Lumbreras Bermejo C., Luna C.M., Lungu O., Luong L., Luque N., Luton D., Lwin N., Lyons R., Maasikas O., Mabiala O., MacDonald S., Machado M., Macheda G., Macias Sanchez J., Madhok J., Maestro de la Calle G., Mahieu R., Mahy S., Maia A.R., Maier L.S., Maillet M., Maitre T., Malfertheiner M., Malik N., Mallon P., Maltez F., Malvy D., Manda V., Mandei J.M., Mandelbrot L., Manetta F., Mangal K., Mankikian J., Manning E., Manuel A., Maria Sant`Ana Malaque C., Marino D., Marino F., Markowicz S., Maroun Eid C., Marques A., Marquis C., Marsh B., Marsh L., Marshal M., Marshall J., Martelli C.T., Martin D.-A., Martin E., Martin-Blondel G., Martinelli A., Martin-Loeches I., Martinot M., Martin-Quiros A., Martins A., Martins J., Martins N., Martins Rego C., Martucci G., Martynenko O., Marwali E.M., Marzukie M., Masa Jimenez J.F., Maslove D., Mason P., Mason S., Masood S., Mat Nor B., Matan M., Mateus Fernandes H., Mathew M., Mathieu D., Mattei M., Matulevics R., Maulin L., Maxwell M., Maynar J., Mazzoni T., Mc Sweeney L., McAndrew L., McArthur C., McCarthy A., McCloskey C., McConnochie R., McDermott S., McDonald S.E., McElroy A., McElwee S., McEneany V., McEvoy N., McGeer A., McKay C., McKeown J., McLean K.A., McNally P., McNicholas B., McPartlan E., Meaney E., Mear-Passard C., Mechlin M., Meher M., Mehkri O., Mele F., Melo L., Memon K., Mendes J.J., Menkiti O., Menon K., Mentre F., Mentzer A.J., Mercier E., Mercier N., Merckx A., Mergeay-Fabre M., Mergler B., Merson L., Mesquita A., Metwally O., Meybeck A., Meyer D., Meynert A.M., Meysonnier V., Meziane A., Mezidi M., Michelagnoli G., Michelanglei C., Michelet I., Mihelis E., Mihnovit V., Miranda-Maldonado H., Misnan N.A., Mohamed N.N.E., Mohamed T.J., Moin A., Molina D., Molinos E., Molloy B., Mone M., Monteiro A., Montes C., Montrucchio G., Moore S., Moore S.C., Morales Cely L., Moro L., Morocho Tutillo D.R., Morton B., Motherway C., Motos A., Mouquet H., Mouton Perrot C., Moyet J., Mudara C., Mufti A.K., Muh N.Y., Muhamad D., Mullaert J., Muller F., Muller K.E., Munblit D., Muneeb S., Munir N., Munshi L., Murphy A., Murphy L., Murris M., Murthy S., Musaab H., Muyandy G., Myrodia D.M., N N., Nagpal D., Nagrebetsky A., Narasimhan M., Narayanan N., Nasim Khan R., Nazerali-Maitland A., Neant N., Neb H., Nekliudov N.A., Nelwan E., Neto R., Neumann E., Neves B., Ng P.Y., Nghi A., Nguyen D., Ni Choileain O., Ni Leathlobhair N., Nichol A., Nitayavardhana P., Nonas S., Noordin N.A.M., Noret M., Norharizam N.F.I., Norman L., Notari A., Noursadeghi M., Nowicka K., Nowinski A., Nseir S., Nunez J.I., Nurnaningsih N., Nyamankolly E., O Brien F., O'Callaghan A., Occhipinti G., OConnor D., O'Donnell M., Ogston T., Ogura T., Oh T.-H., O'Halloran S., O'Hearn K., Ohshimo S., Oldakowska A., Oliveira J., Oliveira L., Olliaro P.L., O'Neil C., Ong D.S.Y., Ong J.Y., Oosthuyzen W., Opavsky A., Openshaw P., Orakzai S., Orozco-Chamorro C.M., Orquera A., Ortoleva J., Osatnik J., O'Shea L., O'Sullivan M., Othman S.Z., Ouamara N., Ouissa R., Owyang C., Oziol E., Pabasara H.M.U., Pagadoy M., Pages J., Palacios A., Palacios M., Palmarini M., Panarello G., Panda P.K., Paneru H., Pang L.H., Panigada M., Pansu N., Papadopoulos A., Parke R., Parker M., Parra B., Parrini V., Pasha T., Pasquier J., Pastene B., Patauner F., Patel J., Pathmanathan M.D., Patrao L., Patricio P., Patrier J., Patterson L., Pattnaik R., Paul C., Paul M., Paulos J., Paxton W.A., Payen J.-F., Peariasamy K., Pedrera Jimenez M., Peek G.J., Peelman F., Peiffer-Smadja N., Peigne V., Pejkovska M., Pelosi P., Peltan I.D., Pereira R., Perez D., Periel L., Perpoint T., Pesenti A., Pestre V., Petrou L., Petrov-Sanchez V., Pettersen F.O., Peytavin G., Pharand S., Piagnerelli M., Picard W., Picone O., de Piero M., Pierobon C., Piersma D., Pimentel C., Pinto R., Pires C., Pironneau I., Piroth L., Pius R., Piva S., Plantier L., Plotkin D., Png H.S., Poissy J., Pokeerbux R., Pokorska-Spiewak M., Poli S., Pollakis G., Ponscarme D., Popielska J., Post A.-M., Postma D.F., Povoa P., Povoas D., Powis J., Prapa S., Preau S., Prebensen C., Preiser J.-C., Prinssen A., Pritchard M.G., Priyadarshani G.D.D., Proenca L., Pudota S., Puechal O., Pujo Semedi B., Pulicken M., Puntoni M., Purcell G., Quesada L., Quinones-Cardona V., Quiros Gonzalez V., Quist-Paulsen E., Quraishi M., Rabaa M., Rabaud C., Rabindrarajan E., Rafael A., Rafiq M., Ragazzo G., Rahman A.K.H.A., Rahman R.A., Rahutullah A., Rainieri F., Rajahram G.S., Rajapakse N., Ralib A., Ramakrishnan N., Ramanathan K., Ramli A.A., Rammaert B., Ramos G.V., Rana A., Rangappa R., Ranjan R., Rapp C., Rashan A., Rashan T., Rasheed G., Rasmin M., Ratsep I., Rau C., Ravi T., Raza A., Real A., Rebaudet S., Redl S., Reeve B., Rehan A., Rehman A., Reid L., Reikvam D.H., Reis R., Rello J., Remppis J., Remy M., Ren H., Renk H., Resende L., Resseguier A.-S., Revest M., Rewa O., Reyes L.F., Reyes T., Ribeiro M.I., Richardson D., Richier L., Ridzuan S.N.A.A., Riera J., Rios A.L., Rishu A., Rispal P., Risso K., Rivera Nunez M.A., Rizer N., Robb D., Robba C., Roberto A., Roberts S., Robertson D.L., Robineau O., Roche-Campo F., Rodari P., Rodeia S., Rodriguez Abreu J., Roessler B., Roger C., Roger 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P., Cisneros Herreros, J. M., Citarella, B. W., Ciullo, A., Clarke, E., Clarke, J., Claure Del Granado, R., Clohisey, S., Cobb, J. P., Coca, N., Codan, C., Cody, C., Coelho, A., Coles, M., Colin, G., Collins, M., Colombo, S. M., Combs, P., Connolly, J., Connor, M., Conrad, A., Contreras, S., Conway, E., Cooke, G. S., Copland, M., Cordel, H., Corley, A., Cormican, S., Cornelis, S., Cornet, A. D., Corpuz, A. J., Cortegiani, A., Corvaisier, G., Costigan, E., Couffignal, C., Couffin-Cadiergues, S., Courtois, R., Cousse, S., Cregan, R., Crepy D'Orleans, C., Croonen, S., Crowl, G., Crump, J., Cruz, C., Cruz Berm, J. L., Cruz Rojo, J., Csete, M., Cucino, A., Cullen, A., Cullen, C., Cummings, M., Curley, G., Curlier, E., Curran, C., Custodio, P., da Silva Filipe, A., Da Silveira, C., Dabaliz, A. -A., Dagens, A., Dahly, D., Dalton, H., Dalton, J., Daly, S., D'Amico, F., Daneman, N., Daniel, C., Dankwa, E. A., Dantas, J., D'Aragon, F., de Boer, M., de Loughry, G., de Mendoza, D., De Montmollin, E., de Oliveira Franca, R. F., de Pinho Oliveira, A. I., De Rosa, R., de Silva, T., de Vries, P., Deacon, J., Dean, D., Debard, A., Debenedictis, B., Debray, M. -P., Decastro, N., Dechert, W., Deconninck, L., Decours, R., Defous, E., Delacroix, I., Delaveuve, E., Delavigne, K., Delfos, N. M., Deligiannis, I., Dell'Amore, A., Delmas, C., Delobel, P., Delsing, C., Demonchy, E., Denis, E., Deplanque, D., Depuydt, P., Desai, M., Descamps, D., Desvallee, M., Dewayanti, S., Diallo, A., Diamantis, S., Dias, A., Diaz, P., Diaz, R., Diaz Diaz, J. J., Didier, K., Diehl, J. -L., Dieperink, W., Dimet, J., Dinot, V., Diop, F., Diouf, A., Dishon, Y., Dixit, D., Djossou, F., Docherty, A. B., Doherty, H., Dondorp, A. M., Dong, A., Donnelly, C. A., Donnelly, M., Donohue, C., Donohue, S., Donohue, Y., Doran, C., Doran, P., Dorival, C., D'Ortenzio, E., Douglas, J. 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W., Granier, P., Grasselli, G., Grazioli, L., Green, C. A., Greene, C., Greenhalf, W., Greffe, S., Grieco, D. L., Griffee, M., Griffiths, F., Grigoras, I., Groenendijk, A., Grosse Lordemann, A., Gruner, H., Gu, Y., Guarracino, F., Guedj, J., Guego, M., Guellec, D., Guerguerian, A. -M., Guerreiro, D., Guery, R., Guillaumot, A., Guilleminault, L., Guimaraes de Castro, M., Guimard, T., Haalboom, M., Haber, D., Habraken, H., Hachemi, A., Hadri, N., Haidash, O., Haider, S., Haidri, F., Hakak, S., Hall, A., Hall, M., Halpin, S., Hamer, A., Hamers, R., Hamidfar, R., Hammond, T., Han, L. Y., Haniffa, R., Hao, K. W., Hardwick, H., Harrison, E. M., Harrison, J., Harrison, S. B. E., Hartman, A., Hashmi, J., Hashmi, M., Hayat, M., Hayes, A., Hays, L., Heerman, J., Heggelund, L., Hendry, R., Hennessy, M., Henriquez, A., Hentzien, M., Herekar, F., Hernandez-Montfort, J., Herr, D., Hershey, A., Hesstvedt, L., Hidayah, A., Higgins, D., Higgins, E., Higginsokeeffe, G., Hinchion, R., Hinton, S., Hiraiwa, H., Hitoto, H., Ho, A., Ho, Y. B., Hoctin, A., Hoffmann, I., Hoh, W. H., Hoiting, O., Holt, R., Holter, J. C., Horby, P., Horcajada, J. P., Hoshino, K., Houas, I., Hough, C. L., Houltham, S., Hsu, J. M. -Y., Hulot, J. -S., Hussain, I., Ijaz, S., Illes, H. -G., Imbert, P., Imran, M., Imran Sikander, R., Inacio, H., Infante Dominguez, C., Ing, Y. S., Iosifidis, E., Ippolito, M., Isgett, S., Ishani, P. G. P. I., Isidoro, T., Ismail, N., Isnard, M., Itai, J., Ito, A., Ivulich, D., Jaafar, D., Jaafoura, S., Jabot, J., Jackson, C., Jamieson, N., Jaquet, P., Jassat, W., Jaud-Fischer, C., Jaureguiberry, S., Javidfar, J., Jawad, I., Jaworsky, D., Jayakumar, D., Jego, F., Jelani, A. M., Jenum, S., Jimbo-Sotomayor, R., Job, V. D. P., Joe, O. Y., Jorge Garcia, R. N., Joseph, C., Joseph, M., Joshi, S., Jourdain, M., Jouvet, P., June, J., Jung, A., Jung, H., Juzar, D., Kafif, O., Kaguelidou, F., Kaisbain, N., Kaleesvran, T., Kali, S., Kalicinska, A., Kalomoiri, S., Kamal, S., Kamaluddin, M. A. A., Kamaruddin, Z. A. C., Kamarudin, N., Kandamby, D. H., Kandel, C., Kang, K. Y., Kant, R., Kanwal, D., Kanyawati, D., Karki, B., Karpayah, P., Karsies, T., Kartsonaki, C., Kasugai, D., Kataria, A., Katz, K., Kaur, A., Kaur Johal, S., Kawasaki, T., Kay, C., Keane, H., Keating, S., Kellam, P., Kelly, A., Kelly, C., Kelly, N., Kelly, S., Kelly, Y., Kelsey, M., Kennedy, R., Kennon, K., Kernan, M., Kerroumi, Y., Keshav, S., Kestelyn, E., Khalid, I., Khalid, O., Khalil, A., Khan, C., Khan, I., Khanal, S., Kho, M. E., Khoo, D., Khoo, R., Khoo, S., Khoso, N., Kiat, K. H., Kida, Y., Kiiza, P., Kildal, A. B., Kim, J. B., Kimmoun, A., Kindgen-Milles, D., King, A., Kitamura, N., Klenerman, P., Klont, R., Kloumann Bekken, G., Knight, S., Kobbe, R., Kodippily, C., Kohns Vasconcelos, M., Koirala, S., Komatsu, M., Korten, V., Kosgei, C., Kpangon, A., Krawczyk, K., Krishnan, S., Krishnan, V., Kruglova, O., Kumar, A., Kumar, D., Kumar, G., Kumar, M., Kumar Vecham, P., Kuriakose, D., Kurtzman, E., Kusumastuti, N. P., Kutsogiannis, D., Kutsyna, G., Kyriakoulis, K., Lachatre, M., Lacoste, M., Laffey, J. G., Lagrange, M., Laine, F., Lairez, O., Lakhey, S., Lalueza, A., Lambert, M., Lamontagne, F., Langelot-Richard, M., Langlois, V., Lantang, E. Y., Lanza, M., Laouenan, C., Laribi, S., Lariviere, D., Lasry, S., Latif, N., Launay, O., Laureillard, D., Lavie-Badie, Y., Law, A., Lawrence, C., Lawrence, T., Le, M., Le Bihan, C., Le Bris, C., Le Falher, G., Le Fevre, L., Le Hingrat, Q., Le Marechal, M., Le Mestre, S., Le Moal, G., Le Moing, V., Le Nagard, H., Le Turnier, P., Leal, E., Leal Santos, M., Lee, B. H., Lee, H. G., Lee, J., Lee, S. H., Lee, T. C., Lee, Y. L., Leeming, G., Lefebvre, B., Lefebvre, L., Lefevre, B., Legac, S., Lelievre, J. -D., Lellouche, F., Lemaignen, A., Lemee, V., Lemeur, A., Lemmink, G., Lene, H. 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V., Rana, A., Rangappa, R., Ranjan, R., Rapp, C., Rashan, A., Rashan, T., Rasheed, G., Rasmin, M., Ratsep, I., Rau, C., Ravi, T., Raza, A., Real, A., Rebaudet, S., Redl, S., Reeve, B., Rehan, A., Rehman, A., Reid, L., Reikvam, D. H., Reis, R., Rello, J., Remppis, J., Remy, M., Ren, H., Renk, H., Resende, L., Resseguier, A. -S., Revest, M., Rewa, O., Reyes, L. F., Reyes, T., Ribeiro, M. I., Richardson, D., Richier, L., Ridzuan, S. N. A. A., Riera, J., Rios, A. L., Rishu, A., Rispal, P., Risso, K., Rivera Nunez, M. A., Rizer, N., Robb, D., Robba, C., Roberto, A., Roberts, S., Robertson, D. L., Robineau, O., Roche-Campo, F., Rodari, P., Rodeia, S., Rodriguez Abreu, J., Roessler, B., Roger, C., Roger, P. -M., Roilides, E., Rojek, A., Romaru, J., Roncon-Albuquerque Jr, R., Roriz, M., Rosa-Calatrava, M., Rose, M., Rosenberger, D., Rossanese, A., Rossetti, M., Rossignol, B., Rossignol, P., Rousset, S., Roy, C., Roze, B., Rusmawatiningtyas, D., Russell, C. D., Ryan, M., Ryckaert, S., Rygh Holten, A., Saba, I., Sadaf, S., Sadat, M., Sahraei, V., Saint-Gilles, M., Sakiyalak, P., Salahuddin, N., Salazar, L., Saleem, J., Sales, G., Sallaberry, S., Salmon Gandonniere, C., Salvator, H., Sanchez, O., Sanchez Choez, X., Sanchez de Oliveira, K., Sanchez-Miralles, A., Sancho-Shimizu, V., Sandhu, G., Sandhu, Z., Sandrine, P. -F., Sandulescu, O., Santos, M., Sarfo-Mensah, S., Sarmento Banheiro, B., Sarmiento, I. C. E., Sarton, B., Satyapriya, S., Satyawati, R., Saviciute, E., Savio, R., Savvidou, P., Saw, Y. T., Schaffer, J., Schermer, T., Scherpereel, A., Schneider, M., Schroll, S., Schwameis, M., Schwartz, G., Scott, J. T., Scott-Brown, J., Sedillot, N., Seitz, T., Selvanayagam, J., Selvarajoo, M., Semaille, C., Semple, M. G., Senian, R. B., Senneville, E., Sepulveda, C., Sequeira, F., Sequeira, T., Serpa Neto, A., Serrano Balazote, P., Shadowitz, E., Shahidan, S. A., Shahnaz Hasan, M., Shamsah, M., Shankar, A., Sharjeel, S., Sharma, P., Shaw, C. A., Shaw, V., Shi, H., Shiban, N., Shiekh, M., Shiga, T., Shime, N., Shimizu, H., Shimizu, K., Shimizu, N., Shindo, N., Shrapnel, S., Shum, H. P., Si Mohammed, N., Siang, N. Y., Sibiude, J., Siddiqui, A., Sigfrid, L., Sillaots, P., Silva, C., Silva, M. J., Silva, R., Sim Lim Heng, B., Sin, W. C., Singh, B. C., Singh, P., Sitompul, P. A., Sivam, K., Skogen, V., Smith, S., Smood, B., Smyth, C., Smyth, M., Snacken, M., So, D., Soh, T. V., Solis, M., Solomon, J., Solomon, T., Somers, E., Sommet, A., Song, M. J., Song, R., Song, T., Song Chia, J., Sonntagbauer, M., Soom, A. M., Sotto, A., Soum, E., Sousa, A. C., Sousa, M., Sousa Uva, M., Souza-Dantas, V., Sperry, A., Spinuzza, E., Sri Darshana, B. P. S. R., Sriskandan, S., Stabler, S., Staudinger, T., Stecher, S. -S., Steinsvik, T., Stienstra, Y., Stiksrud, B., Stolz, E., Stone, A., Streinu-Cercel, A., Strudwick, S., Stuart, A., Stuart, D., Subekti, D., Suen, G., Suen, J. 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Y., Toki, M., Tolppa, T., Tonby, K., Tonnii, S. L., Torres, A., Torres, M., Torres Santos-Olmo, R. M., Torres-Zevallos, H., Towers, M., Trapani, T., Traynor, D., Treoux, T., Trieu, H. T., Tripathy, S., Tromeur, C., Trontzas, I., Trouillon, T., Truong, J., Tual, C., Tubiana, S., Tuite, H., Turmel, J. -M., Turtle, L. C. W., Tveita, A., Twardowski, P., Uchiyama, M., Udayanga, P. I., Udy, A., Ullrich, R., Umer, Z., Uribe, A., Usman, A., Vajdovics, C., Val-Flores, L., Valle, A. L., Valran, A., Van de Velde, S., van den Berge, M., van der Feltz, M., van der Valk, P., Van Der Vekens, N., Van der Voort, P., Van Der Werf, S., van Dyk, M., van Gulik, L., Van Hattem, J., van Lelyveld, S., van Netten, C., Van Twillert, G., van Veen, I., Vanel, N., Vanoverschelde, H., Varghese, P., Varrone, M., Vasudayan, S. R., Vauchy, C., Vaughan, H., Veeran, S., Veislinger, A., Vencken, S., Ventura, S., Verbon, A., Vidal, J. E., Vieira, C., Vijayan, D., Villanueva, J. A., Villar, J., Villeneuve, P. -M., Villoldo, A., Vinh Chau, N. V., Visseaux, B., Visser, H., Vitiello, C., Vonkeman, H., Vuotto, F., Wahab, N. H., Wahab, S. A., Wahid, N. A., Wainstein, M., Wan Muhd Shukeri, W. F., Wang, C. -H., Webb, S. A., Wei, J., Weil, K., Wen, T. P., Wesselius, S., West, T. E., Wham, M., Whelan, B., White, N., Wicky, P. H., Wiedemann, A., Wijaya, S. O., Wille, K., Willems, S., Williams, V., Wils, E. -J., Wing Yiu, N., Wong, C., Wong, T. F., Wong, X. C., Wong, Y. S., Xian, G. E., Xian, L. S., Xuan, K. P., Xynogalas, I., Yacoub, S., Yakop, S. R. B. M., Yamazaki, M., Yazdanpanah, Y., Yee Liang Hing, N., Yelnik, C., Yeoh, C. H., Yerkovich, S., Yokoyama, T., Yonis, H., Yousif, O., Yuliarto, S., Zaaqoq, A., Zabbe, M., Zacharowski, K., Zahid, M., Zahran, M., Zaidan, N. Z. B., Zambon, M., Zambrano, M., Zanella, A., Zawadka, K., Zaynah, N., Zayyad, H., Zoufaly, A., Zucman, D., Intensive Care Medicine, and Group, The ISARIC Clinical Characterisation
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Biomedical Research ,[SDV]Life Sciences [q-bio] ,Clinical science ,Global Health ,Corrections ,Microbiology ,1117 Public Health and Health Services ,1108 Medical Microbiology ,Pandemic ,Economics ,Humans ,ISARIC Clinical Characterisation Group ,Pandemics ,COVID-19/epidemiology ,Actuarial science ,Information Dissemination ,SARS-CoV-2 ,Comment ,ISARIC ,COVID-19 ,1103 Clinical Sciences ,Communicable Disease Control/methods ,Infectious Diseases ,Open source ,Communicable Disease Control ,Value (mathematics) ,Human - Abstract
International audience
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- 2021
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31. How to stop public health conferences becoming trade fairs
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Chiara Francesca Bodini, Camila Giugliani, David McCoy, Waasila Jassat, Ardigò Martino, Kayvan Bozorgmehr, Denise Nascimento, Bodini C., Ardigò M., Mc Coy D., Bozorgmehr K., Nascimento D., Giugliani C., and Jassat W.
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Marketing ,Economic growth ,medicine.medical_specialty ,Nutrition and Dietetics ,CONFLICT OF INTEREST ,Public health ,Commerce ,Public Health, Environmental and Occupational Health ,Medicine (miscellaneous) ,Congresses as Topic ,GLOBAL HEALTH ,HEALTH ETHICS ,Health promotion ,HEALTH INEQUALITIES ,Environmental health ,medicine ,Humans ,Public Health ,Business ,Ethics, Business ,PUBLIC HEALTH POLICY - Abstract
Reflecting the new wave of global public health, which now seems to be finally reoriented towards embracing its social mission and responsibilities, the 12th World Congress on Public Health, recently held in Istanbul, dedicated many of its sessions to ethics and the right to health. Indeed, the Congress title, ‘Making a Difference in Global Public Health: Education, Research and Practice’, sounded like a call to action. But faultless theory and socially responsible state- ments, set out and declared in Istanbul, were accompanied by corporate sponsorship which we see as inappropriate, and sessions that were in conflict with the interests of public health. This commentary reflects the views of a number of participants at the Congress about the corporate influence on public health conferences and, more generally, inap- propriate corporate influence on public health teaching, research and practice.
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32. Actor Sensemaking and its Role in Implementation of the Decentralized Drug-Resistant TB Policy in South Africa.
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Jassat W, Moshabela M, and Schneider H
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South Africa has a high burden of drug-resistant tuberculosis (DR-TB). A policy to decentralize DR-TB treatment from specialized central hospitals to more accessible district facilities was introduced in 2011, but to date implementation has been suboptimal, with variable pace, coverage and models of care emerging. This study explored multilevel policy implementation of DR-TB decentralization in two provinces of South Africa, Western Cape and KwaZulu-Natal. Applying interpretive policy analysis, this paper describes how actors across health system levels and geographies made sense of the DR-TB policy and how this shaped implementation. In an embedded qualitative case study, districts of the two provinces were compared, through data collected in 94 in-depth interviews, and analysed using Vickers' framework of reality, value and action judgements. Five district cases characterise variation in the pace of implementation and models of DR-TB care that emerged. Individual and collective attitudes for and against the policy were underpinned by different systems of meaning for interpreting policy problems and making decisions. These meaning systems were reflected in actor stances on whether DR-TB care needed to be specialized or generalized, nurse- or doctor-led, and institutionalized or ambulatory. Actors' stances influenced their actions and implementation strategies adopted. Resistance to decentralized DR-TB care related to perceived threats of budget cuts to and loss of authority of central facilities, and was often justified in fears of increased transmission, poor quality of care and inadequate resources at lower levels. New advances in diagnosis and treatment to address the growing burden of DR-TB in South Africa will have little impact unless implementation dynamics are better understood, and attention paid to the mindsets, interests and interpretations of policy by actors tasked with implementation. Deliberative policy implementation processes will enhance the quality of discourse, communication and cross-learning between policy actors, critical for reaching synthesis of meaning systems., (© The Author(s) 2024. Published by Oxford University Press in association with The London School of Hygiene and Tropical Medicine.)
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- 2024
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33. Long Covid: a global health issue - a prospective, cohort study set in four continents.
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Pazukhina E, Garcia-Gallo E, Reyes LF, Kildal AB, Jassat W, Dryden M, Holter JC, Chatterjee A, Gomez K, Søraas A, Puntoni M, Latronico N, Bozza FA, Edelstein M, Gonçalves BP, Kartsonaki C, Kruglova O, Gaião S, Chow YP, Doshi Y, Duque Vallejo SI, Ibáñez-Prada ED, Fuentes YV, Hastie C, O'Hara ME, Balan V, Menkir T, Merson L, Kelly S, Citarella BW, Semple MG, Scott JT, Munblit D, and Sigfrid L
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- Humans, Female, Male, Prospective Studies, Middle Aged, Adult, Europe epidemiology, Prevalence, Asia epidemiology, Developed Countries, Africa epidemiology, South America epidemiology, Cohort Studies, COVID-19 epidemiology, Global Health, SARS-CoV-2, Developing Countries, Post-Acute COVID-19 Syndrome
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Introduction: A proportion of people develop Long Covid after acute COVID-19, but with most studies concentrated in high-income countries (HICs), the global burden is largely unknown. Our study aims to characterise long-term COVID-19 sequelae in populations globally and compare the prevalence of reported symptoms in HICs and low-income and middle-income countries (LMICs)., Methods: A prospective, observational study in 17 countries in Africa, Asia, Europe and South America, including adults with confirmed COVID-19 assessed at 2 to <6 and 6 to <12 months post-hospital discharge. A standardised case report form developed by International Severe Acute Respiratory and emerging Infection Consortium's Global COVID-19 Follow-up working group evaluated the frequency of fever, persistent symptoms, breathlessness (MRC dyspnoea scale), fatigue and impact on daily activities., Results: Of 11 860 participants (median age: 52 (IQR: 41-62) years; 52.1% females), 56.5% were from HICs and 43.5% were from LMICs. The proportion identified with Long Covid was significantly higher in HICs vs LMICs at both assessment time points (69.0% vs 45.3%, p<0.001; 69.7% vs 42.4%, p<0.001). Participants in HICs were more likely to report not feeling fully recovered (54.3% vs 18.0%, p<0.001; 56.8% vs 40.1%, p<0.001), fatigue (42.9% vs 27.9%, p<0.001; 41.6% vs 27.9%, p<0.001), new/persistent fever (19.6% vs 2.1%, p<0.001; 20.3% vs 2.0%, p<0.001) and have a higher prevalence of anxiety/depression and impact on usual activities compared with participants in LMICs at 2 to <6 and 6 to <12 months post-COVID-19 hospital discharge, respectively., Conclusion: Our data show that Long Covid affects populations globally, manifesting similar symptomatology and impact on functioning in both HIC and LMICs. The prevalence was higher in HICs versus LMICs. Although we identified a lower prevalence, the impact of Long Covid may be greater in LMICs if there is a lack of support systems available in HICs. Further research into the aetiology of Long Covid and the burden in LMICs is critical to implement effective, accessible treatment and support strategies to improve COVID-19 outcomes for all., Competing Interests: Competing interests: JTS was Co-Chair of the ISARIC COVID Global follow up group. NL received a grant from the Italian Ministry of Health to support this work and received support from the National Congress of the Italian Society of Anesthesia and Critical Care Medicine SIAARTI for travel and accommodation expenses to attend a meeting. MoH Trustee is a Trustee of Long Covid Support., (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY. Published by BMJ.)
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34. Modeling the relative influence of socio-demographic variables on post-acute COVID-19 quality of life.
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Menkir TF, Citarella BW, Sigfrid L, Doshi Y, Reyes LF, Calvache JA, Kildal AB, Nygaard AB, Holter JC, Panda PK, Jassat W, Merson L, Donnelly CA, Santillana M, Buckee C, Verguet S, and Hejazi NS
- Abstract
Importance: Post-acute sequelae of SARS-CoV-2, referred to as "long COVID", are a globally pervasive threat. While their many clinical determinants are commonly considered, their plausible social correlates are often overlooked., Objective: To compare social and clinical predictors of differences in quality of life (QoL) with long COVID. Additionally, to measure how much adjusted associations between social factors and long COVID-associated quality of life are unexplained by important clinical intermediates., Design Setting and Participants: Data from the ISARIC long COVID multi-country prospective cohort study. Subjects from Norway, the United Kingdom (UK), and Russia, aged 16 and above, with confirmed acute SARS-CoV-2 infection reporting >= 1 long COVID-associated symptoms 1+ month following infection., Exposure: The social exposures considered were educational attainment (Norway), employment status (UK and Russia), and female vs male sex (all countries)., Main Outcome and Measures: Quality of life-adjusted days, or QALDs, with long COVID., Results: This cohort study included a total of 3891 participants. In all three countries, educational attainment, employment status, and female sex were important predictors of long COVID QALDs. Furthermore, a majority of the estimated relationships between each of these social correlates and long COVID QALDs could not be attributed to key long COVID-predicting comorbidities. In Norway, 90% (95% CI: 77%, 100%) of the adjusted association between the top two quintiles of educational attainment and long COVID QALDs was not explained by clinical intermediates. The same was true for 86% (73%, 100%) and 93% (80%,100%) of the adjusted associations between full-time employment and long COVID QALDs in the United Kingdom (UK) and Russia. Additionally, 77% (46%,100%) and 73% (52%, 94%) of the adjusted associations between female sex and long COVID QALDs in Norway and the UK were unexplained by the clinical mediators., Conclusions and Relevance: This study highlights the role of socio-economic status indicators and female sex, in line with or beyond commonly cited clinical conditions, as predictors of long COVID-associated QoL, and further reveal that other (non-clinical) mechanisms likely drive their observed relationships. Our findings point to the importance of COVID interventions which go further than an exclusive focus on comorbidity management in order to help redress inequalities in experiences with this chronic disease., Competing Interests: MS has received institutional research funds from the Johnson and Johnson foundation and from Janssen global public health. MS also received institutional research funding from Pfizer.
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- 2024
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35. COVID-19 Vaccine Uptake and Effectiveness by Time since Vaccination in the Western Cape Province, South Africa: An Observational Cohort Study during 2020-2022.
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Kassanjee R, Davies MA, Heekes A, Mahomed H, Hawkridge AJ, Morden E, Jacobs T, Cohen C, Moultrie H, Lessells RJ, Van Der Walt N, Arendse JO, Wolter N, Walaza S, Jassat W, von Gottberg A, Hannan PL, Feikin DR, Cloete K, and Boulle A
- Abstract
There are few data on the real-world effectiveness of COVID-19 vaccines and boosting in Africa, which experienced widespread SARS-CoV-2 infection before vaccine availability. We assessed the association between vaccination and severe COVID-19 in the Western Cape, South Africa, in an observational cohort study of >2 million adults during 2020-2022. We described SARS-CoV-2 testing, COVID-19 outcomes, and vaccine uptake over time. We used multivariable cox models to estimate the association of BNT162b2 and Ad26.COV2.S vaccination with COVID-19-related hospitalization and death, adjusting for demographic characteristics, underlying health conditions, socioeconomic status proxies, and healthcare utilization. We found that by the end of 2022, 41% of surviving adults had completed vaccination and 8% had received a booster dose. Recent vaccination was associated with notable reductions in severe COVID-19 during periods dominated by Delta, and Omicron BA.1/2 and BA.4/5 (sub)lineages. During the latest Omicron BA.4/5 wave, within 3 months of vaccination or boosting, BNT162b2 and Ad26.COV2.S were each 84% effective against death (95% CIs: 57-94 and 49-95, respectively). However, distinct reductions of effectiveness occurred at longer times post completing or boosting vaccination. Results highlight the importance of continued emphasis on COVID-19 vaccination and boosting for those at high risk of severe COVID-19, even in settings with widespread infection-induced immunity.
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- 2024
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36. Association between SARS-CoV-2 gene specific Ct values and COVID-19 associated in-hospital mortality.
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Sikhosana ML, Welch R, Musekiwa A, Makatini Z, Ebonwu J, Blumberg L, and Jassat W
- Abstract
Background: Since there are currently no specific SARS-CoV-2 prognostic viral biomarkers for predicting disease severity, there has been interest in using SARS-CoV-2 polymerase chain reaction (PCR) cycle-threshold (Ct) values to predict disease progression., Objective: This study assessed the association between in-hospital mortality of hospitalized COVID-19 cases and Ct-values of gene targets specific to SARS-CoV-2., Methods: Clinical data of hospitalized COVID-19 cases from Gauteng Province from April 2020-July 2022 were obtained from a national surveillance system and linked to laboratory data. The study period was divided into pandemic waves: Asp614Gly/wave1 (7 June-22 Aug 2020); beta/wave2 (15 Nov 2020-6 Feb 2021); delta/wave3 (9 May-18 Sept 2021) and omicron/wave4 (21 Nov 2021-22 Jan 2022). Ct-value data of genes specific to SARS-CoV-2 according to testing platforms (Roche-ORF gene; GeneXpert-N2 gene; Abbott-RdRp gene) were categorized as low (Ct < 20), mid (Ct20-30) or high (Ct > 30)., Results: There were 1205 recorded cases: 836(69.4%; wave1), 122(10.1%;wave2) 21(1.7%; wave3) and 11(0.9%;in wave4). The cases' mean age(±SD) was 49 years(±18), and 662(54.9%) were female. There were 296(24.6%) deaths recorded: 241(81.4%;wave1), 27 (9.1%;wave2), 6 (2%;wave3), and 2 (0.7%;wave4) ( p < 0.001). Sample distribution by testing platforms was: Roche 1,033 (85.7%), GeneXpert 169 (14%) and Abbott 3 (0.3%). The median (IQR) Ct-values according to testing platform were: Roche 26 (22-30), GeneXpert 38 (36-40) and Abbott 21 (16-24). After adjusting for sex, age and presence of a comorbidity, the odds of COVID-19 associated death were high amongst patients with Ct values 20-30[adjusted Odds Ratio (aOR) 2.25; 95% CI: 1.60-3.18] and highest amongst cases with Ct-values <20 (aOR 3.18; 95% CI: 1.92-5.27), compared to cases with Ct-values >30., Conclusion: Although odds of COVID19-related death were high amongst cases with Ct-values <30, Ct values were not comparable across different testing platforms, thus precluding the comparison of SARS-CoV-2 Ct-value results., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (© 2024 Sikhosana, Welch, Musekiwa, Makatini, Ebonwu, Blumberg and Jassat.)
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- 2024
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37. Trends in COVID-19 admissions and deaths among people living with HIV in South Africa: analysis of national surveillance data.
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Jassat W, Mudara C, Ozougwu L, Welch R, Arendse T, Masha M, Blumberg L, Kufa T, Puren A, Groome M, Govender N, Pisa P, Govender S, Sanne I, Brahmbhatt H, Parmley L, Wolmarans M, Rousseau P, Selikow A, Burgess M, Hankel L, Parker A, and Cohen C
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- Adult, Humans, South Africa epidemiology, SARS-CoV-2, COVID-19 Vaccines, COVID-19, HIV Infections complications, HIV Infections epidemiology
- Abstract
Background: In 2021, the HIV prevalence among South African adults was 18% and more than 2 million people had uncontrolled HIV and, therefore, had increased risk of poor outcomes with SARS-CoV-2 infection. We investigated trends in COVID-19 admissions and factors associated with in-hospital COVID-19 mortality among people living with HIV and people without HIV., Methods: In this analysis of national surveillance data, we linked and analysed data collected between March 5, 2020, and May 28, 2022, from the DATCOV South African national COVID-19 hospital surveillance system, the SARS-CoV-2 case line list, and the Electronic Vaccination Data System. All analyses included patients hospitalised with SARS-CoV-2 with known in-hospital outcomes (ie, who were discharged alive or had died) at the time of data extraction. We used descriptive statistics for admissions and mortality trends. Using post-imputation random-effect multivariable logistic regression models, we compared characteristics and the case fatality ratio of people with HIV and people without HIV. Using modified Poisson regression models, we compared factors associated with mortality among all people with COVID-19 admitted to hospital and factors associated with mortality among people with HIV., Findings: Among 397 082 people with COVID-19 admitted to hospital, 301 407 (75·9%) were discharged alive, 89 565 (22·6%) died, and 6110 (1·5%) had no recorded outcome. 270 737 (68·2%) people with COVID-19 had documented HIV status (22 858 with HIV and 247 879 without). Comparing characteristics of people without HIV and people with HIV in each COVID-19 wave, people with HIV had increased odds of mortality in the D614G (adjusted odds ratio 1·19, 95% CI 1·09-1·29), beta (1·08, 1·01-1·16), delta (1·10, 1·03-1·18), omicron BA.1 and BA.2 (1·71, 1·54-1·90), and omicron BA.4 and BA.5 (1·81, 1·41-2·33) waves. Among all COVID-19 admissions, mortality was lower among people with previous SARS-CoV-2 infection (adjusted incident rate ratio 0·32, 95% CI 0·29-0·34) and with partial (0·93, 0·90-0·96), full (0·70, 0·67-0·73), or boosted (0·50, 0·41-0·62) COVID-19 vaccination. Compared with people without HIV who were unvaccinated, people without HIV who were vaccinated had lower risk of mortality (0·68, 0·65-0·71) but people with HIV who were vaccinated did not have any difference in mortality risk (1·08, 0·96-1·23). In-hospital mortality was higher for people with HIV with CD4 counts less than 200 cells per μL, irrespective of viral load and vaccination status., Interpretation: HIV and immunosuppression might be important risk factors for mortality as COVID-19 becomes endemic., Funding: South African National Institute for Communicable Diseases, the South African National Government, and the United States Agency for International Development., Competing Interests: Declaration of interests We declare no competing interests., (Copyright © 2024 Elsevier Ltd. All rights reserved.)
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- 2024
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38. Organisation of care for people receiving drug-resistant tuberculosis treatment in South Africa: a mixed methods study.
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Dickson L, Le Roux SR, Mitrani L, Hill J, Jassat W, Cox H, Mlisana K, Black J, Loveday M, Grant A, Kielmann K, Ndjeka N, Moshabela M, and Nicol M
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- Humans, South Africa, Rifampin, Hospitalization, Antitubercular Agents therapeutic use, Tuberculosis, Multidrug-Resistant drug therapy
- Abstract
Objectives: Treatment for multidrug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB) is increasingly transitioning from hospital-centred to community-based care. A national policy for decentralised programmatic MDR/RR-TB care was adopted in South Africa in 2011. We explored variations in the implementation of care models in response to this change in policy, and the implications of these variations for people affected by MDR/RR-TB., Design: A mixed methods study was done of patient movements between healthcare facilities, reconstructed from laboratory records. Facility visits and staff interviews were used to determine reasons for movements., Participants and Setting: People identified with MDR/RR-TB from 13 high-burden districts within South Africa., Outcome Measures: Geospatial movement patterns were used to identify organisational models. Reasons for patient movement and implications of different organisational models for people affected by MDR/RR-TB and the health system were determined., Results: Among 191 participants, six dominant geospatial movement patterns were identified, which varied in average hospital stay (0-281 days), average patient distance travelled (12-198 km) and number of health facilities involved in care (1-5 facilities). More centralised models were associated with longer delays to treatment initiation and lengthy hospitalisation. Decentralised models facilitated family-centred care and were associated with reduced time to treatment and hospitalisation duration. Responsiveness to the needs of people affected by MDR/RR-TB and health system constraints was achieved through implementation of flexible models, or the implementation of multiple models in a district., Conclusions: Understanding how models for organising care have evolved may assist policy implementers to tailor implementation to promote particular patterns of care organisation or encourage flexibility, based on patient needs and local health system resources. Our approach can contribute towards the development of a health systems typology for understanding how policy-driven models of service delivery are implemented in the context of variable resources., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY. Published by BMJ.)
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- 2023
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39. A multi-country analysis of COVID-19 hospitalizations by vaccination status.
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Gonçalves BP, Jassat W, Baruch J, Hashmi M, Rojek A, Dasgupta A, Martin-Loeches I, Reyes LF, Piubelli C, Citarella BW, Kartsonaki C, Lefèvre B, López Revilla JW, Lunn M, Harrison EM, Kraemer MUG, Shrapnel S, Horby P, Bisoffi Z, Olliaro PL, and Merson L
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- Humans, SARS-CoV-2, Hospitalization, Hospitals, Vaccination, COVID-19 epidemiology, COVID-19 prevention & control
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Background: Individuals vaccinated against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), when infected, can still develop disease that requires hospitalization. It remains unclear whether these patients differ from hospitalized unvaccinated patients with regard to presentation, coexisting comorbidities, and outcomes., Methods: Here, we use data from an international consortium to study this question and assess whether differences between these groups are context specific. Data from 83,163 hospitalized COVID-19 patients (34,843 vaccinated, 48,320 unvaccinated) from 38 countries were analyzed., Findings: While typical symptoms were more often reported in unvaccinated patients, comorbidities, including some associated with worse prognosis in previous studies, were more common in vaccinated patients. Considerable between-country variation in both in-hospital fatality risk and vaccinated-versus-unvaccinated difference in this outcome was observed., Conclusions: These findings will inform allocation of healthcare resources in future surges as well as design of longer-term international studies to characterize changes in clinical profile of hospitalized COVID-19 patients related to vaccination history., Funding: This work was made possible by the UK Foreign, Commonwealth and Development Office and Wellcome (215091/Z/18/Z, 222410/Z/21/Z, 225288/Z/22/Z, and 220757/Z/20/Z); the Bill & Melinda Gates Foundation (OPP1209135); and the philanthropic support of the donors to the University of Oxford's COVID-19 Research Response Fund (0009109). Additional funders are listed in the "acknowledgments" section., Competing Interests: Declaration of interests I.M.-L. declares lectures for Gilead, Thermo Fisher, and MSD; advisory board participation for Fresenius Kabi, Advanz Pharma, Gilead, Accelerate, and Merck; and consulting fees for Gilead outside of the submitted work. S.S. participated as an investigator for an observational study analyzing ICU patients with COVID-19 (for the Critical Care Consortium, including ECMOCARD) funded by The Prince Charles Hospital Foundation during the conduct of this study. B.L. declares travel/accommodation/meeting expenses from Mylan and Gilead, all outside the submitted work., (Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)
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- 2023
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40. International Pediatric COVID-19 Severity Over the Course of the Pandemic.
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Zhu Y, Almeida FJ, Baillie JK, Bowen AC, Britton PN, Brizuela ME, Buonsenso D, Burgner D, Chew KY, Chokephaibulkit K, Cohen C, Cormier SA, Crawford N, Curtis N, Farias CGA, Gilks CF, von Gottberg A, Hamer D, Jarovsky D, Jassat W, Jesus AR, Kemp LS, Khumcha B, McCallum G, Miller JE, Morello R, Munro APS, Openshaw PJM, Padmanabhan S, Phongsamart W, Reubenson G, Ritz N, Rodrigues F, Rungmaitree S, Russell F, Sáfadi MAP, Saner C, Semple MG, Prado da Silva DGB, de Sousa LMM, Diogo Moço Souza M, Spann K, Walaza S, Wolter N, Xia Y, Yeoh DK, Zar HJ, Zimmermann P, and Short KR
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- Adolescent, Humans, Child, Male, Infant, Child, Preschool, Female, SARS-CoV-2, Pandemics, Oxygen, COVID-19 epidemiology
- Abstract
Importance: Multiple SARS-CoV-2 variants have emerged over the COVID-19 pandemic. The implications for COVID-19 severity in children worldwide are unclear., Objective: To determine whether the dominant circulating SARS-CoV-2 variants of concern (VOCs) were associated with differences in COVID-19 severity among hospitalized children., Design, Setting, and Participants: Clinical data from hospitalized children and adolescents (younger than 18 years) who were SARS-CoV-2 positive were obtained from 9 countries (Australia, Brazil, Italy, Portugal, South Africa, Switzerland, Thailand, UK, and the US) during 3 different time frames. Time frames 1 (T1), 2 (T2), and 3 (T3) were defined to represent periods of dominance by the ancestral virus, pre-Omicron VOCs, and Omicron, respectively. Age groups for analysis were younger than 6 months, 6 months to younger than 5 years, and 5 to younger than 18 years. Children with an incidental positive test result for SARS-CoV-2 were excluded., Exposures: SARS-CoV-2 hospitalization during the stipulated time frame., Main Outcomes and Measures: The severity of disease was assessed by admission to intensive care unit (ICU), the need for ventilatory support, or oxygen therapy., Results: Among 31 785 hospitalized children and adolescents, the median age was 4 (IQR 1-12) years and 16 639 were male (52.3%). In children younger than 5 years, across successive SARS-CoV-2 waves, there was a reduction in ICU admission (T3 vs T1: risk ratio [RR], 0.56; 95% CI, 0.42-0.75 [younger than 6 months]; RR, 0.61, 95% CI; 0.47-0.79 [6 months to younger than 5 years]), but not ventilatory support or oxygen therapy. In contrast, ICU admission (T3 vs T1: RR, 0.39, 95% CI, 0.32-0.48), ventilatory support (T3 vs T1: RR, 0.37; 95% CI, 0.27-0.51), and oxygen therapy (T3 vs T1: RR, 0.47; 95% CI, 0.32-0.70) decreased across SARS-CoV-2 waves in children 5 years to younger than 18 years old. The results were consistent when data were restricted to unvaccinated children., Conclusions and Relevance: This study provides valuable insights into the impact of SARS-CoV-2 VOCs on the severity of COVID-19 in hospitalized children across different age groups and countries, suggesting that while ICU admissions decreased across the pandemic in all age groups, ventilatory and oxygen support generally did not decrease over time in children aged younger than 5 years. These findings highlight the importance of considering different pediatric age groups when assessing disease severity in COVID-19.
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- 2023
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41. Long COVID in low-income and middle-income countries: the hidden public health crisis.
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Jassat W, Reyes LF, Munblit D, Caoili J, Bozza F, Hashmi M, Edelstein M, Cohen C, Alvarez-Moreno CA, and Cao B
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- Humans, Public Health, Post-Acute COVID-19 Syndrome, Developing Countries, Poverty, COVID-19 epidemiology
- Abstract
Competing Interests: CC reports grants from US Centers for Disease Control and Prevention, Sanofi Pasteur, Wellcome Trust, Bill and Melinda Gates Foundation, and PATH outside of the submitted work. LFR reports grants and personal fees from Merck and Pfizer and personal fees from GSK outside of the submitted work. DM is principal investigator of the StopCOVID observational cohort study and co-leads the Post COVID-Core Outcome Set project. JC reports grants from Wellcome Trust, Philippine Council for Health Research and Development, Pfizer, and Zuellig Pharma outside of the submitted work. WJ, FB, MH, ME, CAA-M, and BC declare no competing interests.
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- 2023
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42. Risks of Adverse Outcomes for Hospitalized COVID-19 Patients during the Four Waves in Brazil According to SARS-CoV-2 Variants, Age Group, and Vaccine Status.
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Hojo-Souza NS, Jassat W, Guidoni DL, and de Souza FSH
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- Aged, Humans, Adolescent, Young Adult, Adult, Middle Aged, SARS-CoV-2 genetics, Brazil epidemiology, Hospital Mortality, COVID-19 epidemiology, COVID-19 prevention & control, Vaccines
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Brazil was hit with four consecutive waves of COVID-19 until 2022 due to the ancestral SARS-CoV-2 (B.1 lineage), followed by the emergence of variants/subvariants. Relative risks of adverse outcomes for COVID-19 patients hospitalized during the four waves were evaluated. Data were extracted from the largest Brazilian database (SIVEP-Gripe), and COVID-19 patients who were hospitalized during the peak of each of the four waves (15-week intervals) were included in this study. The outcomes of in-hospital death, invasive (IMV) and non-invasive (NIV) ventilation requirements, and intensive care unit (ICU) admission were analyzed to estimate the relative risks. A higher risk of in-hospital death was found during the second wave for all age groups, but a significant reduction was observed in the risk of death for the elderly during the third and fourth waves compared to patients in the first wave. There was an increased risk of IMV requirement and ICU admissions during the second wave for patients aged 18-59 years old compared to the first wave. Relative risk analysis showed that booster-vaccinated individuals have lower risks of in-hospital death and IMV requirement in all age groups compared to unvaccinated/partially vaccinated patients, demonstrating the relevance of full/booster vaccination in reducing adverse outcomes for patients who were hospitalized during the variant prevalence.
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- 2023
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43. Estimating the time-varying reproduction number for COVID-19 in South Africa during the first four waves using multiple measures of incidence for public and private sectors across four waves.
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Bingham J, Tempia S, Moultrie H, Viboud C, Jassat W, Cohen C, and Pulliam JRC
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- Humans, South Africa epidemiology, Communicable Disease Control, Incidence, Pandemics, Private Sector, Reproduction, COVID-19 epidemiology
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Objectives: The aim of this study was to quantify transmission trends in South Africa during the first four waves of the COVID-19 pandemic using estimates of the time-varying reproduction number (R) and to compare the robustness of R estimates based on three different data sources, and using data from public and private sector service providers., Methods: R was estimated from March 2020 through April 2022, nationally and by province, based on time series of rt-PCR-confirmed cases, hospitalisations, and hospital-associated deaths, using a method that models daily incidence as a weighted sum of past incidence, as implemented in the R package EpiEstim. R was also estimated separately using public and private sector data., Results: Nationally, the maximum case-based R following the introduction of lockdown measures was 1.55 (CI: 1.43-1.66), 1.56 (CI: 1.47-1.64), 1.46 (CI: 1.38-1.53) and 3.33 (CI: 2.84-3.97) during the first (Wuhan-Hu), second (Beta), third (Delta), and fourth (Omicron) waves, respectively. Estimates based on the three data sources (cases, hospitalisations, deaths) were generally similar during the first three waves, but higher during the fourth wave for case-based estimates. Public and private sector R estimates were generally similar except during the initial lockdowns and in case-based estimates during the fourth wave., Conclusion: Agreement between R estimates using different data sources during the first three waves suggests that data from any of these sources could be used in the early stages of a future pandemic. The high R estimates for Omicron relative to earlier waves are interesting given a high level of exposure pre-Omicron. The agreement between public and private sector R estimates highlights that clients of the public and private sectors did not experience two separate epidemics, except perhaps to a limited extent during the strictest lockdowns in the first wave., Competing Interests: CC has received grant support from Sanofi Pasteur, US CDC, Wellcome Trust, Programme for Applied Technologies in Health (PATH), Bill & Melinda Gates Foundation and South African Medical Research Council (SA-MRC). JRCP has received funding for COVID-related work from Bill & Melinda Gates Foundation, WHO AFRO, and Wellcome Trust and serves on the Ministerial Advisory Committee for COVID-19 for the South African National Department of Health. The other authors report no known conflicts of interest. This does not alter our adherence to PLOS ONE policies on sharing data and materials., (Copyright: © 2023 Bingham et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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- 2023
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44. The association of SARS-CoV-2 infection and tuberculosis disease with unfavorable treatment outcomes: A systematic review.
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Vadlamudi NK, Basham CA, Johnston JC, Ahmad Khan F, Battista Migliori G, Centis R, D'Ambrosio L, Jassat W, Davies MA, Schwartzman K, and Campbell JR
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Background: Whether SARS-CoV-2 infection and its management influence tuberculosis (TB) treatment outcomes is uncertain. We synthesized evidence on the association of SARS-CoV-2 coinfection (Coinfection Review) and its management (Clinical Management Review) on treatment outcomes among people with tuberculosis (TB) disease., Methods: We systematically searched the literature from 1 January 2020 to 6 February 2022. Primary outcomes included: unfavorable (death, treatment failure, loss-to-follow-up) TB treatment outcomes (Coinfection and Clinical Management Review) and/or severe or critical COVID-19 or death (Clinical Management Review). Study quality was assessed with an adapted Newcastle Ottawa Scale. Data were heterogeneous and a narrative review was performed. An updated search was performed on April 3, 2023., Findings: From 9,529 records, we included 11 studies and 7305 unique participants. No study reported data relevant to our review in their primary publication and data had to be contributed by study authors after contact. Evidence from all studies was low quality. Eight studies of 5749 persons treated for TB (286 [5%] with SARS-CoV-2) were included in the Coinfection Review. Across five studies reporting our primary outcome, there was no significant association between SARS-CoV-2 coinfection and unfavorable TB treatment outcomes. Four studies of 1572 TB patients-of whom 291 (19%) received corticosteroids or other immunomodulating treatment-were included in the Clinical Management Review, and two addressed a primary outcome. Studies were likely confounded by indication and discordant findings existed among studies. When updating our search, we still did not identify any study reporting data relevant to this review in their primary publication., Interpretation: No study was designed to answer our research questions of interest. It remains unclear whether TB/SARS-CoV-2 and its therapeutic management are associated with unfavorable outcomes. Research is needed to improve our understanding of risk and optimal management of persons with TB and SARS-CoV-2 infection., Trial Registration: Registration: PROSPERO (CRD42022309818)., Competing Interests: The authors have read the journal’s policy and have the following competing interests: NKV reports receiving consulting fees from Broadstreet HEOR for unrelated projects outside of the submitted work. JRC reports receiving consulting fees from the COVID-19 Immunity Task Force (Canada) and The World Bank, for unrelated projects outside of the submitted work. This does not alter our adherence to PLOS policies on sharing data and materials., (Copyright: © 2023 Vadlamudi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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- 2023
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45. Differential in-hospital mortality and intensive care treatment over time: Informing hospital pathways for modelling COVID-19 in South Africa.
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Jamieson L, Van Schalkwyk C, Nichols BE, Meyer-Rath G, Silal S, Pulliam J, Blumberg L, Cohen C, Moultrie H, and Jassat W
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There are limited published data within sub-Saharan Africa describing hospital pathways of COVID-19 patients hospitalized. These data are crucial for the parameterisation of epidemiological and cost models, and for planning purposes for the region. We evaluated COVID-19 hospital admissions from the South African national hospital surveillance system (DATCOV) during the first three COVID-19 waves between May 2020 and August 2021. We describe probabilities and admission into intensive care units (ICU), mechanical ventilation, death, and lengths of stay (LOS) in non-ICU and ICU care in public and private sectors. A log-binomial model was used to quantify mortality risk, ICU treatment and mechanical ventilation between time periods, adjusting for age, sex, comorbidity, health sector and province. There were 342,700 COVID-19-related hospital admissions during the study period. Risk of ICU admission was 16% lower during wave periods (adjusted risk ratio (aRR) 0.84 [0.82-0.86]) compared to between-wave periods. Mechanical ventilation was more likely during a wave overall (aRR 1.18 [1.13-1.23]), but patterns between waves were inconsistent, while mortality risk in non-ICU and ICU were 39% (aRR 1.39 [1.35-1.43]) and 31% (aRR 1.31 [1.27-1.36]) higher during a wave, compared to between-wave periods, respectively. If patients had had the same probability of death during waves vs between-wave periods, we estimated approximately 24% [19%-30%] of deaths (19,600 [15,200-24,000]) would not have occurred over the study period. LOS differed by age (older patients stayed longer), ward type (ICU stays were longer than non-ICU) and death/recovery outcome (time to death was shorter in non-ICU); however, LOS remained similar between time periods. Healthcare capacity constraints as inferred by wave period have a large impact on in-hospital mortality. It is crucial for modelling health systems strain and budgets to consider how input parameters related to hospitalisation change during and between waves, especially in settings with severely constrained resources., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2023 Jamieson et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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- 2023
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46. Using generalized structured additive regression models to determine factors associated with and clusters for COVID-19 hospital deaths in South Africa.
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Maposa I, Welch R, Ozougwu L, Arendse T, Mudara C, Blumberg L, and Jassat W
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- Humans, Bayes Theorem, Hospitalization, Hospitals, SARS-CoV-2, South Africa epidemiology, COVID-19
- Abstract
Background: The first case of COVID-19 in South Africa was reported in March 2020 and the country has since recorded over 3.6 million laboratory-confirmed cases and 100 000 deaths as of March 2022. Transmission and infection of SARS-CoV-2 virus and deaths in general due to COVID-19 have been shown to be spatially associated but spatial patterns in in-hospital deaths have not fully been investigated in South Africa. This study uses national COVID-19 hospitalization data to investigate the spatial effects on hospital deaths after adjusting for known mortality risk factors., Methods: COVID-19 hospitalization data and deaths were obtained from the National Institute for Communicable Diseases (NICD). Generalized structured additive logistic regression model was used to assess spatial effects on COVID-19 in-hospital deaths adjusting for demographic and clinical covariates. Continuous covariates were modelled by assuming second-order random walk priors, while spatial autocorrelation was specified with Markov random field prior and fixed effects with vague priors respectively. The inference was fully Bayesian., Results: The risk of COVID-19 in-hospital mortality increased with patient age, with admission to intensive care unit (ICU) (aOR = 4.16; 95% Credible Interval: 4.05-4.27), being on oxygen (aOR = 1.49; 95% Credible Interval: 1.46-1.51) and on invasive mechanical ventilation (aOR = 3.74; 95% Credible Interval: 3.61-3.87). Being admitted in a public hospital (aOR = 3.16; 95% Credible Interval: 3.10-3.21) was also significantly associated with mortality. Risk of in-hospital deaths increased in months following a surge in infections and dropped after months of successive low infections highlighting crest and troughs lagging the epidemic curve. After controlling for these factors, districts such as Vhembe, Capricorn and Mopani in Limpopo province, and Buffalo City, O.R. Tambo, Joe Gqabi and Chris Hani in Eastern Cape province remained with significantly higher odds of COVID-19 hospital deaths suggesting possible health systems challenges in those districts., Conclusion: The results show substantial COVID-19 in-hospital mortality variation across the 52 districts. Our analysis provides information that can be important for strengthening health policies and the public health system for the benefit of the whole South African population. Understanding differences in in-hospital COVID-19 mortality across space could guide interventions to achieve better health outcomes in affected districts., (© 2023. The Author(s).)
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- 2023
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47. COVID-19 in-hospital mortality during the first two pandemic waves, at Helen Joseph Hospital, South Africa.
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Reid J, Daya R, Zingoni ZM, Jassat W, Bayat Z, and Nel J
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- Humans, Male, Middle Aged, Female, SARS-CoV-2, Pandemics, South Africa epidemiology, Hospital Mortality, Retrospective Studies, Hospitals, Oxygen, COVID-19
- Abstract
Introduction: there has been significant global variation in Coronavirus Disease (COVID-19) mortality at different time points in the pandemic. Contributing factors include population demographics, comorbidities, health system capacity, prior infection with COVID-19, vaccinations, and viral variants. The study aims to describe COVID-19-related mortality of inpatients at Helen Joseph Hospital (HJH), over 12 months, during the first two waves of the COVID-19 pandemic in South Africa. The primary objectives were to describe the socio-demographic details, clinical characteristics, and hospital outcomes during the first and second waves of COVID-19. This included an assessment of the in-hospital case fatality ratio (CFR) of patients admitted with COVID-19. The secondary objectives were to compare the socio-demographic details, clinical characteristics, and outcomes between the two waves, and to determine risk factors associated with COVID-19-related mortality., Methods: this is a retrospective cohort study of all inpatient laboratory-confirmed COVID-19 cases at HJH from 1
st May 2020 to 31st April 2021. Data were collected by the National Institute for Communicable Diseases (NICD). Bivariate analysis was performed to describe and compare the socio-demographic characteristics, clinical characteristics, and hospital admission outcomes between the two waves. Multivariate logistic regression was used to determine risk factors for COVID-19-related mortality., Results: overall, 1359 patients were admitted, 595 in wave one, and 764 in wave two. Patients were predominantly male (52.4%), of Black African race (75.1%) with a mean age of 54.6 (standard deviation 15.4) years. The median length of stay was 8 days (interquartile range 5-14 days). In total, 73.2% (995) of patients required oxygen, 5.2% (71) of patients received mechanical ventilation, and 7.1% (96) were admitted to the high care and Intensive Care Unit (ICU). The most common comorbid illnesses were hypertension (36.7%, n=499), diabetes mellitus (26.6%, n=362), Human Immunodeficiency Virus (HIV) (10.8%, n=147), and obesity (11.0%, n=149). The in-hospital CFR during the first wave was 30.4% (181/595) and 25.5% (195/764) (p<0.001) in the second wave, and overall, in-hospital CFR was 27.7% (376/1359). The adjusted odds of death were 79% higher among patients admitted during wave one compared to wave two (aOR=1.79; 95% CI: 1.35-2.38). A one-year increase in age increased the odds of death by 4% (aOR=1.04; 95% CI: 1.03-1.05). The need for oxygen (aOR=2.17, 95%CI: 1.56-3.01) and ventilation (aOR=7.23, 95% CI: 4.02-13.01) were significant risk factors for mortality., Conclusion: prior to the availability of vaccines, COVID-19-related mortality was high and risk factors for mortality were consistent with national and international findings. This study reflects the impact of the pandemic on the South African public sector with limited resources and minimal ICU capacity., Competing Interests: The authors declare no competing interests., (Copyright: Joanna Reid et al.)- Published
- 2023
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48. Characteristics and outcomes of an international cohort of 600 000 hospitalized patients with COVID-19.
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Kartsonaki C, Baillie JK, Barrio NG, Baruch J, Beane A, Blumberg L, Bozza F, Broadley T, Burrell A, Carson G, Citarella BW, Dagens A, Dankwa EA, Donnelly CA, Dunning J, Elotmani L, Escher M, Farshait N, Goffard JC, Gonçalves BP, Hall M, Hashmi M, Sim Lim Heng B, Ho A, Jassat W, Pedrera Jiménez M, Laouenan C, Lissauer S, Martin-Loeches I, Mentré F, Merson L, Morton B, Munblit D, Nekliudov NA, Nichol AD, Singh Oinam BC, Ong D, Panda PK, Petrovic M, Pritchard MG, Ramakrishnan N, Ramos GV, Roger C, Sandulescu O, Semple MG, Sharma P, Sigfrid L, Somers EC, Streinu-Cercel A, Taccone F, Vecham PK, Kumar Tirupakuzhi Vijayaraghavan B, Wei J, Wils EJ, Ci Wong X, Horby P, Rojek A, and Olliaro PL
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- Humans, Male, Child, Middle Aged, SARS-CoV-2, Intensive Care Units, Proportional Hazards Models, Risk Factors, Hospitalization, COVID-19 therapy
- Abstract
Background: We describe demographic features, treatments and clinical outcomes in the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) COVID-19 cohort, one of the world's largest international, standardized data sets concerning hospitalized patients., Methods: The data set analysed includes COVID-19 patients hospitalized between January 2020 and January 2022 in 52 countries. We investigated how symptoms on admission, co-morbidities, risk factors and treatments varied by age, sex and other characteristics. We used Cox regression models to investigate associations between demographics, symptoms, co-morbidities and other factors with risk of death, admission to an intensive care unit (ICU) and invasive mechanical ventilation (IMV)., Results: Data were available for 689 572 patients with laboratory-confirmed (91.1%) or clinically diagnosed (8.9%) SARS-CoV-2 infection from 52 countries. Age [adjusted hazard ratio per 10 years 1.49 (95% CI 1.48, 1.49)] and male sex [1.23 (1.21, 1.24)] were associated with a higher risk of death. Rates of admission to an ICU and use of IMV increased with age up to age 60 years then dropped. Symptoms, co-morbidities and treatments varied by age and had varied associations with clinical outcomes. The case-fatality ratio varied by country partly due to differences in the clinical characteristics of recruited patients and was on average 21.5%., Conclusions: Age was the strongest determinant of risk of death, with a ∼30-fold difference between the oldest and youngest groups; each of the co-morbidities included was associated with up to an almost 2-fold increase in risk. Smoking and obesity were also associated with a higher risk of death. The size of our international database and the standardized data collection method make this study a comprehensive international description of COVID-19 clinical features. Our findings may inform strategies that involve prioritization of patients hospitalized with COVID-19 who have a higher risk of death., (© The Author(s) 2023. Published by Oxford University Press on behalf of the International Epidemiological Association.)
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- 2023
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49. Changing Epidemiology of COVID-19 in Children and Adolescents Over Four Successive Epidemic Waves in South Africa, 2020-2022.
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Chiwandire N, Jassat W, Groome M, Kufa T, Walaza S, Wolter N, von Gottberg A, Zar HJ, Reubenson G, Tempia S, Ebonwu J, Govender N, Ntshoe G, Shonhiwa AM, Blumberg L, and Cohen C
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- Adult, Infant, Humans, Adolescent, Child, SARS-CoV-2, COVID-19 Testing, South Africa epidemiology, Hospitalization, COVID-19 epidemiology
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Background: South Africa experienced four waves of SARS-CoV-2 infection, dominated by Wuhan-Hu, Beta, Delta, and Omicron (BA.1/BA.2). We describe the trends in SARS-CoV-2 testing, cases, admissions, and deaths among children and adolescents in South Africa over successive waves., Methods: We analyzed national SARS-CoV-2 testing, case, and admissions data from March 2020 to February 2022 and estimated cumulative rates by age group for each endpoint. The severity in the third versus the fourth wave was assessed using multivariable logistic regression., Results: Individuals ≤18 years comprised 35% (21,008,060/60,142,978) of the population but only 12% (424,394/3,593,644) of cases and 6% (26,176/451,753) of admissions. Among individuals ≤18 years, infants had the highest admission (505/100,000) rates. Testing, case, and admission rates generally increased successively in the second (Beta) and third (Delta) waves among all age groups. In the fourth (Omicron BA.1/BA.2) wave, the case rate dropped among individuals ≥1 year but increased among those <1 year. Weekly admission rates for children <1 year (169/100,000) exceeded rates in adults (124/100,000) in the fourth wave. The odds of severe COVID-19 in all admitted cases were lower in the fourth wave versus the third wave in each age group, but they were twice as high in admitted cases with at least one comorbidity than those without., Conclusions: The admission rate for children <5 years was higher in the fourth wave than in previous waves, but the overall outcomes were less severe. However, children with at least one comorbidity had increased odds of severe disease, warranting consideration of prioritizing this group for vaccination., (© The Author(s) 2023. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society.)
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- 2023
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50. Trends in Cases, Hospitalizations, and Mortality Related to the Omicron BA.4/BA.5 Subvariants in South Africa.
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Jassat W, Abdool Karim SS, Ozougwu L, Welch R, Mudara C, Masha M, Rousseau P, Wolmarans M, Selikow A, Govender N, Walaza S, von Gottberg A, Wolter N, Terrence Pisa P, Sanne I, Govender S, Blumberg L, Cohen C, and Groome MJ
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- Humans, South Africa epidemiology, SARS-CoV-2, Hospitalization, Hospitals, COVID-19 epidemiology, Laboratory Infection
- Abstract
Background: In this study, we compared admission incidence risk and the risk of mortality in the Omicron BA.4/BA.5 wave to previous waves., Methods: Data from South Africa's SARS-CoV-2 case linelist, national COVID-19 hospital surveillance system, and Electronic Vaccine Data System were linked and analyzed. Wave periods were defined when the country passed a weekly incidence of 30 cases/100 000 population. In-hospital case fatality ratios (CFRs) during the Delta, Omicron BA.1/BA.2, and Omicron BA.4/BA.5 waves were compared using post-imputation random effect multivariable logistic regression models., Results: The CFR was 25.9% (N = 37 538 of 144 778), 10.9% (N = 6123 of 56 384), and 8.2% (N = 1212 of 14 879) in the Delta, Omicron BA.1/BA.2, and Omicron BA.4/BA.5 waves, respectively. After adjusting for age, sex, race, comorbidities, health sector, and province, compared with the Omicron BA.4/BA.5 wave, patients had higher risk of mortality in the Omicron BA.1/BA.2 wave (adjusted odds ratio [aOR], 1.3; 95% confidence interval [CI]: 1.2-1.4) and Delta wave (aOR, 3.0; 95% CI: 2.8-3.2). Being partially vaccinated (aOR, 0.9; 95% CI: .9-.9), fully vaccinated (aOR, 0.6; 95% CI: .6-.7), and boosted (aOR, 0.4; 95% CI: .4-.5) and having prior laboratory-confirmed infection (aOR, 0.4; 95% CI: .3-.4) were associated with reduced risks of mortality., Conclusions: Overall, admission incidence risk and in-hospital mortality, which had increased progressively in South Africa's first 3 waves, decreased in the fourth Omicron BA.1/BA.2 wave and declined even further in the fifth Omicron BA.4/BA.5 wave. Mortality risk was lower in those with natural infection and vaccination, declining further as the number of vaccine doses increased., Competing Interests: Potential conflicts of interest. S. S. A. K. reports grants or contracts unrelated to this work and paid to institution from the National Institutes of Health, South African Medical Research Council Cooperative Agreement, National Research Foundation/DST, USAID/Right to Care Cooperative agreement, the IQRAA Trust, and EDCTP; an unpaid role as a member of the World Health Organization (WHO) Science Council; a paid role as a member of the Bill and Melinda Gates Foundation (BMGF) Scientific Advisory Committee (meeting honorarium paid to author); and an unpaid role as vice-president of the International Science Council. C. C. reports grants or contracts unrelated to this work and paid to institution from the US Centers for Disease Control and Prevention (CDC), Wellcome Trust, Sanofi Pasteur, PATH, BMGF, and SA-Medical Research Council. A. v. G. reports grants unrelated to this work and paid to institution from the BMGF, Sanofi, CDC, WHO AFRO, Fleming Fund SEQAFRICA, SA MRC, the Solidarity Fund for Innovative Projects, NIH training grant, and ASLM PGI and a role as chair for the National Advisory Group for Immunisation. I. S. reports an institutional grant unrelated to this work from NIH DAIDS–WITS Helen Joseph Hospital CRS. M. J. G. reports grants or contracts unrelated to this work and paid to institution from the South African Medical Research Council and BMGF. N. W. reports grants paid to institution and unrelated to this work from the BMGF, Sanofi, and CDC. R. W. reports shareholding with Adcock Ingram Holdings Ltd, Dischem Pharmacies Ltd, Discovery Ltd, Netcare Ltd, and Aspen Pharmacare Holdings Ltd. S. W. reports grants unrelated to this work and paid to institution from the BMGF, Sanofi, CDC, and Welcome Trust. W. J. reports grants or contracts related to a long coronavirus disease 2019 study, paid to institution, from the BMGF. All remaining authors: No reported conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed., (© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America.)
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- 2023
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