75 results on '"Jason Adams"'
Search Results
2. Comparing the quality of neural network uncertainty estimates for classification problems.
- Author
-
Daniel Ries, Joshua Michalenko, Tyler Ganter, Rashad Imad-Fayez Baiyasi, and Jason Adams
- Published
- 2022
- Full Text
- View/download PDF
3. Comparing the quality of neural network uncertainty estimates for classification problems.
- Author
-
Daniel Ries, Joshua Michalenko, Tyler Ganter, Rashad Imad-Fayez Baiyasi, and Jason Adams
- Published
- 2023
- Full Text
- View/download PDF
4. Target Detection on Hyperspectral Images Using MCMC and VI Trained Bayesian Neural Networks.
- Author
-
Daniel Ries, Jason Adams, and Joshua Zollweg
- Published
- 2023
- Full Text
- View/download PDF
5. Eterotopie anarchiche
- Author
-
Salvo Vaccaro, Jason Adams, Maia Ramnath, Evren Süreyyya, Kathy E. Ferguson, Arif Dirlik, John A. Rapp, Ryan Allen Knight, Claudia Campisano
- Published
- 2020
6. A Molecularly Imprinted Electrochemical Gas Sensor to Sense Butylated Hydroxytoluene in Air.
- Author
-
Shadi Emam, Adedokun Adedoyin, Xiaohua Geng, Mohsen Zaeimbashi, Jason Adams, Adam Ekenseair, Elizabeth Podlaha-Murphy, and Nian Xiang Sun
- Published
- 2018
- Full Text
- View/download PDF
7. Supplementary Tables 1-3, Figures 1-4 from SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo
- Author
-
Siegfried H. Reich, Stephen K. Burley, Spencer Emtage, Stephen R. Wasserman, Kevin Holme, Shane Atwell, Laura A. Pelletier, Lydia Smyth, Devon A. Thompson, Paul A. Sprengeler, Jeff M. Blaney, Tuan H. Do, Barbara C. Leon, Jason Adams, Isabelle A. Rooney, Marijane Russell, Kenneth D. Schwinn, J. Michael Sauder, Steve F. Gessert, Brandon E. Aubol, Marshall C. Peterman, Karen J. Froning, Jeremy D. Felce, Nanni H. Huser, Crystal M. Tang, Katti A. Jessen, Pierre-Yves Bounaud, Christopher R. Smith, Patrick S. Lee, Jorg Hendle, and Sean G. Buchanan
- Abstract
Supplementary Tables 1-3, Figures 1-4 from SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo
- Published
- 2023
- Full Text
- View/download PDF
8. Supplementary Figure 1 from SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo
- Author
-
Siegfried H. Reich, Stephen K. Burley, Spencer Emtage, Stephen R. Wasserman, Kevin Holme, Shane Atwell, Laura A. Pelletier, Lydia Smyth, Devon A. Thompson, Paul A. Sprengeler, Jeff M. Blaney, Tuan H. Do, Barbara C. Leon, Jason Adams, Isabelle A. Rooney, Marijane Russell, Kenneth D. Schwinn, J. Michael Sauder, Steve F. Gessert, Brandon E. Aubol, Marshall C. Peterman, Karen J. Froning, Jeremy D. Felce, Nanni H. Huser, Crystal M. Tang, Katti A. Jessen, Pierre-Yves Bounaud, Christopher R. Smith, Patrick S. Lee, Jorg Hendle, and Sean G. Buchanan
- Abstract
Supplementary Figure 1 from SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo
- Published
- 2023
- Full Text
- View/download PDF
9. Data from SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo
- Author
-
Siegfried H. Reich, Stephen K. Burley, Spencer Emtage, Stephen R. Wasserman, Kevin Holme, Shane Atwell, Laura A. Pelletier, Lydia Smyth, Devon A. Thompson, Paul A. Sprengeler, Jeff M. Blaney, Tuan H. Do, Barbara C. Leon, Jason Adams, Isabelle A. Rooney, Marijane Russell, Kenneth D. Schwinn, J. Michael Sauder, Steve F. Gessert, Brandon E. Aubol, Marshall C. Peterman, Karen J. Froning, Jeremy D. Felce, Nanni H. Huser, Crystal M. Tang, Katti A. Jessen, Pierre-Yves Bounaud, Christopher R. Smith, Patrick S. Lee, Jorg Hendle, and Sean G. Buchanan
- Abstract
The MET receptor tyrosine kinase has emerged as an important target for the development of novel cancer therapeutics. Activation of MET by mutation or gene amplification has been linked to kidney, gastric, and lung cancers. In other cancers, such as glioblastoma, autocrine activation of MET has been demonstrated. Several classes of ATP-competitive inhibitor have been described, which inhibit MET but also other kinases. Here, we describe SGX523, a novel, ATP-competitive kinase inhibitor remarkable for its exquisite selectivity for MET. SGX523 potently inhibited MET with an IC50 of 4 nmol/L and is >1,000-fold selective versus the >200-fold selectivity of other protein kinases tested in biochemical assays. Crystallographic study revealed that SGX523 stabilizes MET in a unique inactive conformation that is inaccessible to other protein kinases, suggesting an explanation for the selectivity. SGX523 inhibited MET-mediated signaling, cell proliferation, and cell migration at nanomolar concentrations but had no effect on signaling dependent on other protein kinases, including the closely related RON, even at micromolar concentrations. SGX523 inhibition of MET in vivo was associated with the dose-dependent inhibition of growth of tumor xenografts derived from human glioblastoma and lung and gastric cancers, confirming the dependence of these tumors on MET catalytic activity. Our results show that SGX523 is the most selective inhibitor of MET catalytic activity described to date and is thus a useful tool to investigate the role of MET kinase in cancer without the confounding effects of promiscuous protein kinase inhibition. [Mol Cancer Ther 2009;8(12):3181–90]
- Published
- 2023
- Full Text
- View/download PDF
10. A Statistical Assessment of Zener Diode Behavior Using Functional Data Analysis
- Author
-
Xiaoxia Champon, David Angeles, Thomas Buchheit, David Canfield, J. Derek Tucker, and Jason Adams
- Published
- 2023
- Full Text
- View/download PDF
11. Mean Estimation and Nominal Device Selection with the Pairwise Midpoint Method
- Author
-
Jason Adams, Thomas Buchheit, Abdullah Al Mamun Mazumder, Biazid Kabir Moghal, Md Fazle Rabbe, Ahsanul Islam, and Shahed Reza
- Published
- 2023
- Full Text
- View/download PDF
12. Radio astronomy and Space science in Azores: Enhancing the Atlantic VLBI infrastructure cluster
- Author
-
Bruno Morgado, Dalmiro Maia, Sonia Anton, Diogo Gomes, Domingos Barbosa, Bruno Coelho, João Paulo Barraca, Tjarda Boekholt, João Pandeirada, V. A. R. M. Ribeiro, Alexandre C. M. Correia, Jason Adams, and Miguel Bergano
- Subjects
Atmospheric Science ,010504 meteorology & atmospheric sciences ,Computer science ,media_common.quotation_subject ,FOS: Physical sciences ,Aerospace Engineering ,NASA Deep Space Network ,01 natural sciences ,Space exploration ,Physics - Space Physics ,0103 physical sciences ,Very-long-baseline interferometry ,Instrumentation and Methods for Astrophysics (astro-ph.IM) ,010303 astronomy & astrophysics ,0105 earth and related environmental sciences ,media_common ,business.industry ,Astronomy and Astrophysics ,Atlantic connections ,Space Physics (physics.space-ph) ,Geophysics ,Space and Planetary Science ,Sky ,Space tracking ,Radioastronomy ,General Earth and Planetary Sciences ,Satellite ,Space Science ,Astrophysics - Instrumentation and Methods for Astrophysics ,Telecommunications ,business ,Very Long Baseline Interferometry [Techniques] ,Space debris ,Radio astronomy - Abstract
Radio astronomy and Space Infrastructures in the Azores have a great scientific and industrial interest because they benefit from a unique geographical location in the middle of the North Atlantic allowing a vast improvement in the sky coverage. This fact obviously has a very high added value for: i) the establishment of space tracking and communications networks for the emergent global small satellite fleets ii) it is invaluable to connect the radio astronomy infrastructure networks in Africa, Europe and America continents using Very Large Baseline Interferometry (VLBI) techniques, iii) it allows excellent potential for monitoring space debris and Near Earth Objects (NEOs). There is in S. Miguel island a 32-metre SATCOM antenna that could be integrated in advanced VLBI networks and be capable of additional Deep Space Network ground support. This paper explores the space science opportunities offered by the upgrade of the S. Miguel 32-metre SATCOM antenna into a world-class infrastructure for radio astronomy and space exploration: it would enable a Deep Space Network mode and would constitute a key space facility for data production, promoting local digital infrastructure investments and the testing of cutting-edge information technologies. Its Atlantic location also enables improvements in angular resolution, provides many baseline in East-West and North-South directions connecting the emergent VLBI stations in America to Europe and Africa VLBI arrays therefore contributing for greater array imaging capabilities especially for sources or well studied fields close to or below the celestial equator, where ESO facilities, ALMA, SKA and its precursors do or will operate and observe in the coming decades., Comment: 14 pages, 7 figures, 3 tables. Accepted for Publication at Advances in Space Research, COSPAR, Elsevier
- Published
- 2021
- Full Text
- View/download PDF
13. From vital signs to clinical outcomes for patients with sepsis: a machine learning basis for a clinical decision support system.
- Author
-
Eren Gultepe, Jeffrey P. Green, Hien Nguyen, Jason Adams, Timothy E. Albertson, and Ilias Tagkopoulos
- Published
- 2014
- Full Text
- View/download PDF
14. Acute beneficial effects of a functional energy shot on cognitive performance and mood states during cognitively demanding task performance: a randomized, double-blind, placebo-controlled, crossover trial
- Author
-
Olivia K. O’Shea, Nathan Lawley, Anna Azzopardi, Allison Gutkowski, Michelle Murphy Niedziela, Rachel Horn, David O. Kennedy, and Jason Adamson
- Subjects
energy ,mood ,cognition ,performance ,trial ,supplement ,Nutrition. Foods and food supply ,TX341-641 - Abstract
IntroductionFunctional beverages are increasingly popular but it is important to validate their purported effects through research. The aim of the current study was to investigate the effects of a new functional energy shot on cognitive performance and mood states in healthy adults, with a focus on measuring mental energy enhancement and attenuation of negative effects associated with extended performance of mentally demanding tasks.MethodsThis study was a randomized, double-blind, placebo-controlled, crossover trial. Thirty-seven healthy males and females, aged 18–30 years, consumed a functional energy shot (Ryde: Energize) or placebo on separate testing occasions one-week apart. Participants completed cognitive and mood assessments pre-dose, and then 30 minutes post-dose over the course of approximately 2 hours. The functional energy shot contained caffeine, ginseng, vitamins and taurine, while the placebo shot was matched for flavor but did not contain these additional ingredients.ResultsUse of the functional energy shot was associated with significant improvements over placebo in cognitive performance, as measured by the Cognitive Demand Battery, with enhanced global performance, task-specific accuracy and speed across repeated assessments. Additionally, the shot mitigated negative effects associated with extended cognitive tasks, reducing perceived mental fatigue and increasing perceived alertness and energy. Working memory tasks showed faster performance post-consumption, and mood assessments revealed positive effects on vigor, fatigue and overall mood disturbance.DiscussionThese results indicate wide cognitive and mood effects of this functional energy shot, potentially attributable to synergistic combination of active ingredients.Clinical trial registrationclinicaltrials.gov, identifier NCT06384586.
- Published
- 2025
- Full Text
- View/download PDF
15. Phenotypic trait extraction of soybean plants using deep convolutional neural networks with transfer learning
- Author
-
George L Graef, Jason Adams, Yumou Qiu, Luis Posadas, and Kent M. Eskridge
- Subjects
business.industry ,Computer science ,Pattern recognition ,Image processing ,General Medicine ,Phenotypic trait ,Image segmentation ,Convolutional neural network ,Field (computer science) ,Phenomics ,Trait ,Artificial intelligence ,Transfer of learning ,business - Abstract
High-throughput plant phenotyping systems capable of producing large numbers of images have been constructed in recent years. In order for statistical analysis of plant traits to be possible, image processing must take place. This paper considers the extraction of plant trait data from soybean images taken in the University of Nebraska-Lincoln Greenhouse Innovation Center. Using transfer learning, which utilizes the VGG16 model along with its parameters in the convolutional layers as part of our model, convolutional neural networks (CNNs) are trained to predict measurements such as height, width, and size of the plants. It is demonstrated that, by making use of transfer learning, our CNNs efficiently and accurately extract the trait measurements from the images using a relatively small amount of training data. This approach to plant trait extraction is new to the field of plant phenomics, and the superiority of our CNN-based trait extraction approach to an image segmentation-based approach is demonstrated.
- Published
- 2021
- Full Text
- View/download PDF
16. Mechanical Energy Dissipation Through the Ossicular Chain and Inner Ear Using Laser Doppler Vibrometer Measurement of Round Window Velocity
- Author
-
Carlos R. Esquivel, John Lally, Samuel A. Spear, Jason Adams, Mostafa M Ahmed, Matthew Ryan, Sophie Higgins, and James K. Aden
- Subjects
Acoustics ,Incus ,Vibration ,03 medical and health sciences ,0302 clinical medicine ,otorhinolaryngologic diseases ,medicine ,Humans ,Inner ear ,030223 otorhinolaryngology ,Ear Ossicles ,Stapes ,Round window ,Ossicles ,business.industry ,Lasers ,Temporal Bone ,Sensory Systems ,Ossicular Prosthesis ,medicine.anatomical_structure ,Round Window, Ear ,Otorhinolaryngology ,Middle ear ,sense organs ,Neurology (clinical) ,business ,Laser Doppler vibrometer ,030217 neurology & neurosurgery - Abstract
Hypothesis Round window velocity measurements should correlate closely with vibration measurements taken at proximal points along an intact chain over a set frequency range. These round window vibration measurements should be similar to the vibration measurements taken of the ossicles if mechanical energy is conserved through the vestibular organ. Background To date there has not been a study which compares vibratory velocity measurements through an intact ossicular chain to the level of the round window. This study attempted to quantify the degree of mechanical energy transmission and suspected dissipation through the ossicular chain and vestibular organ through incus, stapes, and round window velocity measurements in response to sound stimulus. Methods Five thawed human temporal bones with intact ossicular chain and tympanic membrane underwent complete mastoidectomy and a facial recess approach. A laser Doppler vibrometer (LDV) was mounted on the operating microscope to measure vibration of incus, stapes, and round window in response to a sound stimulus within the external auditory canal. Sound stimulus frequencies ranged from 0.5 to 4 kHz at 90 dB SPL. Results Vibration velocity was measured across the frequency range for each incus, stapes, and round window. Vibration velocity curves obtained over the frequency range were similar for each of the bones with a notable resonant frequency around 2 kHz. The incus and stapes curve amplitudes were nearly identical with similar maximum velocity and frequency at which this maximal velocity was noted. Round window vibration velocity demonstrated a unique peak velocity. Transfer function measurements of the stapes and round window demonstrated markedly similar curves. The variation in velocity between temporal bones in response to the standardized stimulus was more dramatic in the round window measurements when compared with the incus and stapes. Conclusions This study supports the concept that round window transfer function is equivalent to stapes footplate transfer function when subjected to the same acoustic stimuli. This study also demonstrates that the round window is a much more difficult target to measure when using LDV technology and improvements in experimental design are required to better understand round window physiology in relation to transfer of acoustic vibratory stimulus transferred throughout the middle ear. A complete and thorough understanding of the biophysical properties of the middle and inner ear are critical for optimal ossiculoplasty outcomes and the development of future ossicular prosthetics.
- Published
- 2020
- Full Text
- View/download PDF
17. Comparison of Acute Diffusion Tensor Imaging and Conventional Magnetic Resonance Parameters in Predicting Long-Term Outcome after Blunt Cervical Spinal Cord Injury
- Author
-
Bizhan Aarabi, Jiachen Zhuo, Sudini Kuladeep, Rao P Gullapallie, Catriona Miller, Kathirkamanathan Shanmuganathan, Uttam K. Bodanapally, Jay Menakar, and Jason Adams
- Subjects
Adult ,Male ,030506 rehabilitation ,medicine.medical_specialty ,Time Factors ,Walking ,behavioral disciplines and activities ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Blunt ,Predictive Value of Tests ,medicine ,Humans ,Longitudinal Studies ,Prospective Studies ,Spinal cord injury ,Spinal Cord Injuries ,Aged ,medicine.diagnostic_test ,business.industry ,Cervical Cord ,Magnetic resonance imaging ,Recovery of Function ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Cervical spine ,Diffusion Tensor Imaging ,nervous system ,Cervical spinal cord injury ,Female ,Neurology (clinical) ,Radiology ,0305 other medical science ,business ,030217 neurology & neurosurgery ,Follow-Up Studies ,Diffusion MRI - Abstract
This prospective longitudinal study compares the ability of conventional and diffusion tensor imaging (DTI) parameters made at the cervical spinal cord injury (CSCI) site to predict long-term neurological and functional outcomes. Twenty patients with CSCI, with follow-up at 6 or 12 months, and 15 control volunteers were included. Conventional magnetic resonance imaging (MRI) and DTI parameters were measured on admission and follow-up studies. Stepwise regression analysis was performed to find relevant parameters (normalized DTI values, conventional MRI measurements, hemorrhagic contusion [HC] or non-HC [NHC]) that correlated with three primary outcome measures: patient International Standards for Neurological Classification of Spinal Cord Injury total motor score (ISNCSCI-TMS), ability to walk, and expected recovery of upper limb motor scores (ER-ULMS) at 6 or 12 months. Univariate analysis showed HC (
- Published
- 2020
- Full Text
- View/download PDF
18. Target Detection on Hyperspectral Images Using MCMC and VI Trained Bayesian Neural Networks
- Author
-
Daniel Ries, Jason Adams, and Joshua Zollweg
- Published
- 2022
- Full Text
- View/download PDF
19. Characterizing Electrical Device Behavior with Functional Tolerance Bounds
- Author
-
Jason Adams, James Tucker, David Angeles, Tabytha Perez, Thomas Buchheit, and Shahed Reza
- Published
- 2021
- Full Text
- View/download PDF
20. Semi-supervised Bayesian Low-shot Learning
- Author
-
Jason Adams, Katherine Goode, Joshua Michalenko, Phillip Lewis, Daniel Ries, and Josh Zollweg
- Published
- 2021
- Full Text
- View/download PDF
21. Implementation of a Novel Order Set to Improve Baseline Pulmonary, Hepatic, and Thyroid Function Testing at Time of Inpatient Amiodarone Initiation
- Author
-
Steven P. Dunn, Nishaki Mehta, Evan Harmon, Jason Adams, John D. Voss, Jacob N Blackwell, Jonathan A. Pan, Olusola Laja, Matthew Q. Miller, and Laurie Brock
- Subjects
medicine.medical_specialty ,business.industry ,MEDLINE ,Amiodarone ,Arrhythmias, Cardiac ,Retrospective cohort study ,Thyroid Function Tests ,Respiratory Function Tests ,Liver Function Tests ,Internal medicine ,Cardiology ,Humans ,Medicine ,Thyroid function ,Cardiology and Cardiovascular Medicine ,business ,Baseline (configuration management) ,Anti-Arrhythmia Agents ,Retrospective Studies ,Order set ,medicine.drug - Published
- 2020
- Full Text
- View/download PDF
22. Measuring the Effect of Child Benefit on Household Expenditures: Evidence from Canadian Households’ Survey Data
- Author
-
Sid Ali Amedah, Jason Adams, and Maxime Fougère
- Subjects
Receipt ,Child care ,Child benefit ,Permanent income hypothesis ,Economics ,General Earth and Planetary Sciences ,Survey data collection ,Household income ,Demographic economics ,General Environmental Science - Abstract
This study examines the effects of the Canada Child Benefit on household expenditures. Estimation of child benefit impact on household expenditure is challenging since benefit and household income may be endogenously determined. Relying on permanent income hypothesis and based on Engel’s approach, findings suggest that spending patterns vary by household composition and income, but overall results indicate that receipt of this benefit is associated with a significant increase in households’ wellbeing. More specifically, expenditure elasticities estimates indicate that spending on child care for households receiving higher proportions of the benefit is the most sensitive spending to any change in household permanent income, which may indicate the existence of financial constraints for those households that prevent them from maximizing their utility. Similarly, spending on school-related items for those receiving lower proportions also represents a sensitive spending.
- Published
- 2020
- Full Text
- View/download PDF
23. A Complete Fisheries Inventory of the Chulitna River Basin, Lake Clark National Park and Preserve, Alaska: Example of a Minimally Disturbed Basin
- Author
-
Jason Adams, Alan T. Herlihy, Daniel B. Young, Robert M. Hughes, and George Boxall
- Subjects
Fishery ,Geography ,geography.geographical_feature_category ,National park ,Drainage basin ,Aquatic Science ,Structural basin ,Ecology, Evolution, Behavior and Systematics - Published
- 2020
- Full Text
- View/download PDF
24. A study of emotional speech articulation using a fast magnetic resonance imaging technique.
- Author
-
Sungbok Lee, Erik Bresch, Jason Adams, Abe Kazemzadeh, and Shrikanth S. Narayanan
- Published
- 2006
- Full Text
- View/download PDF
25. The use of cochlear implantation in the elderly
- Author
-
Brent J Wilkerson, Jason Adams, and John W. Lally
- Subjects
medicine.medical_specialty ,Hearing loss ,Hearing Loss, Sensorineural ,medicine.medical_treatment ,MEDLINE ,Audiology ,03 medical and health sciences ,Cognition ,0302 clinical medicine ,Quality of life ,Cochlear implant ,otorhinolaryngologic diseases ,medicine ,Humans ,Verbal comprehension ,030223 otorhinolaryngology ,Cochlear implantation ,Aged ,Rehabilitation ,business.industry ,Hearing Tests ,Cochlear Implantation ,Treatment Outcome ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Quality of Life ,Surgery ,medicine.symptom ,business - Abstract
Purpose of review To evaluate the impact of cochlear implantation on hearing outcomes, quality of life, complications, and cognitive function in elderly patients. Recent findings Nine articles published between 2014 and 2019 pertain to cochlear implantation in the elderly population. The findings conclude that cochlear implantation improves autonomy and overall quality of life in the elderly. Summary Design: a pubmed search was employed with title search terms 'cochlear implant,' AND 'elderly' or 'aged.' Twenty-one articles were generated. Of the 21, articles without evidence-based findings were excluded and those published more than 5 years ago were excluded, yielding a final number of nine articles for review. Results nine articles published on the use of cochlear implantation in the elderly were identified through the literature search between the years 2014-2019. Outcomes included quality of life, speech recognition improvement, improvement in cognitive function as defined by geriatric validated scales, outcomes of hearing rehabilitation, improvement in verbal comprehension, surgical complications, and the ability to manage the external components of the device. Conclusion cochlear implantation improves autonomy and the quality of life in the elderly. Age should not be a factor limiting surgical decision-making, and cochlear implantation can be utilized as a well tolerated, efficient treatment option for severe-to-profound hearing loss in the elderly population.
- Published
- 2019
- Full Text
- View/download PDF
26. Ibiza-gate: The story behind Austria's political hurricane
- Author
-
Jason Adams
- Abstract
Ibiza - a place where sunny dreams thrive - and political ambitions are shattered. At least for former Austrian vice-chancellor Heinz-Christian Strache. The then-opposition leader of the right-wing Freedom Party (FPÖ) was caught on video, filmed in July 2017 byIrena Markovic, discussing dirty tricks to win the upcoming election - and to solidify his power with the help of what he perceived were big-money Russian facilitators. But Strache was set up. On May 17, 2019, the six-hour video was released to the media. "Ibiza-gate" was about to shake the foundations of the country's political life. Chancellor Sebastian Kurz immediately distanced himself from his coalition partner. Strache felt cornered. "Yes, I was drunk and I used this intimate setting to pontificate about everything, but I lost control." Then a bombshell. "I just had a meeting with Chancellor Sebastian Kurz ... in which ... I offered my resignation from the position of vice-chancellor of the Republic of Austria and he accepted," he announced. Effectively ending the coalition, Chancellor Kurz asked Austria's President Alexander van der Bellen to initiate early elections, just hours after Strache's press conference. Both agreed that this was the only way out. "There needs to be a swift renewal, as swift as the Constitution allows it," said Van der Bellen. But Kurz's days as chancellor were now numbered. He had asked van der Bellen to dismiss the controversial Freedom Party interior minister, prompting the resignation of all of the party's cabinet members. There was now open warfare between Kurz and the FPÖ. Feeling emboldened, the opposition Social Democrats filed a motion of no-confidence against the minority chancellor - and received support from the Freedom Party. With these forces lined up against him, Kurz did not stand a chance. After only a year and a half in office, Kurz was the first Austrian chancellor to be ousted that way in the history of the republic. A week later, van der Bellen appointed the president of Austria's Constitutional Court, Brigitte Bierlein, as interim chancellor. She is the first woman ever to serve in that position. Her term is expected to end following the new elections on September 29.
- Published
- 2021
- Full Text
- View/download PDF
27. Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients With COVID-19: A Randomized Clinical Trial
- Author
-
Wesley H, Self, Matthew W, Semler, Lindsay M, Leither, Jonathan D, Casey, Derek C, Angus, Roy G, Brower, Steven Y, Chang, Sean P, Collins, John C, Eppensteiner, Michael R, Filbin, D Clark, Files, Kevin W, Gibbs, Adit A, Ginde, Michelle N, Gong, Frank E, Harrell, Douglas L, Hayden, Catherine L, Hough, Nicholas J, Johnson, Akram, Khan, Christopher J, Lindsell, Michael A, Matthay, Marc, Moss, Pauline K, Park, Todd W, Rice, Bryce R H, Robinson, David A, Schoenfeld, Nathan I, Shapiro, Jay S, Steingrub, Christine A, Ulysse, Alexandra, Weissman, Donald M, Yealy, B Taylor, Thompson, Samuel M, Brown, Jay, Steingrub, Howard, Smithline, Bogdan, Tiru, Mark, Tidswell, Lori, Kozikowski, Sherell, Thornton-Thompson, Leslie, De Souza, Peter, Hou, Rebecca, Baron, Anthony, Massaro, Imoigele, Aisiku, Lauren, Fredenburgh, Raghu, Seethala, Lily, Johnsky, Richard, Riker, David, Seder, Teresa, May, Michael, Baumann, Ashley, Eldridge, Christine, Lord, Nathan, Shapiro, Daniel, Talmor, Thomas, O’Mara, Charlotte, Kirk, Kelly, Harrison, Lisa, Kurt, Margaret, Schermerhorn, Valerie, Banner-Goodspeed, Katherine, Boyle, Nicole, Dubosh, Michael, Filbin, Kathryn, Hibbert, Blair, Parry, Kendall, Lavin-Parsons, Natalie, Pulido, Brendan, Lilley, Carl, Lodenstein, Justin, Margolin, Kelsey, Brait, Alan, Jones, James, Galbraith, Rebekah, Peacock, Utsav, Nandi, Taylor, Wachs, Michael, Matthay, Kathleen, Liu, Kirsten, Kangelaris, Ralph, Wang, Carolyn, Calfee, Kimberly, Yee, Gregory, Hendey, Steven, Chang, George, Lim, Nida, Qadir, Andrea, Tam, Rebecca, Beutler, Joseph, Levitt, Jenny, Wilson, Angela, Rogers, Rosemary, Vojnik, Jonasel, Roque, Timothy, Albertson, James, Chenoweth, Jason, Adams, Skyler, Pearson, Maya, Juarez, Eyad, Almasri, Mohamed, Fayed, Alyssa, Hughes, Shelly, Hillard, Ryan, Huebinger, Henry, Wang, Elizabeth, Vidales, Bela, Patel, Adit, Ginde, Amiran, Baduashvili, Jeffrey, McKeehan, Lani, Finck, Carrie, Higgins, Michelle, Howell, Ivor, Douglas, Jason, Haukoos, Terra, Hiller, Carolynn, Lyle, Alicia, Cupelo, Emily, Caruso, Claudia, Camacho, Stephanie, Gravitz, James, Finigan, Christine, Griesmer, Pauline, Park, Robert, Hyzy, Kristine, Nelson, Kelli, McDonough, Norman, Olbrich, Mark, Williams, Raj, Kapoor, Jean, Nash, Meghan, Willig, Henry, Ford, Jayna, Gardner-Gray, Mayur, Ramesh, Montefiore, Moses, Michelle, Ng Gong, Michael, Aboodi, Ayesha, Asghar, Omowunmi, Amosu, Madeline, Torres, Savneet, Kaur, Jen-Ting, Chen, Aluko, Hope, Brenda, Lopez, Kathleen, Rosales, Jee, Young You, Jarrod, Mosier, Cameron, Hypes, Bhupinder, Natt, Bryan, Borg, Elizabeth, Salvagio Campbell, R Duncan, Hite, Kristin, Hudock, Autumn, Cresie, Faysal, Alhasan, Jose, Gomez-Arroyo, Abhijit, Duggal, Omar, Mehkri, Andrei, Hastings, Debasis, Sahoo, Francois, Abi Fadel, Susan, Gole, Valerie, Shaner, Allison, Wimer, Yvonne, Meli, Alexander, King, Thomas, Terndrup, Matthew, Exline, Sonal, Pannu, Emily, Robart, Sarah, Karow, Catherine, Hough, Bryce, Robinson, Nicholas, Johnson, Daniel, Henning, Monica, Campo, Stephanie, Gundel, Sakshi, Seghal, Sarah, Katsandres, Sarah, Dean, Olivia, Krol, Milad, Jouzestani, Peter, Huynh, Donald, Yealy, Denise, Scholl, Peter, Adams, Bryan, McVerry, David, Huang, Derek, Angus, Jordan, Schooler, Steven, Moore, Clark, Files, Chadwick, Miller, Kevin, Gibbs, Mary, LaRose, Lori, Flores, Lauren, Koehler, Caryn, Morse, John, Sanders, Caitlyn, Langford, Kristen, Nanney, Masiku, MdalaGausi, Phyllis, Yeboah, Peter, Morris, Jamie, Sturgill, Sherif, Seif, Evan, Cassity, Sanjay, Dhar, Marjolein, de Wit, Jessica, Mason, Andrew, Goodwin, Greg, Hall, Abbey, Grady, Amy, Chamberlain, Samuel, Brown, Joseph, Bledsoe, Lindsay, Leither, Ithan, Peltan, Nathan, Starr, Melissa, Fergus, Valerie, Aston, Quinn, Montgomery, Rilee, Smith, Mardee, Merrill, Katie, Brown, Brent, Armbruster, Estelle, Harris, Elizabeth, Middleton, Robert, Paine, Stacy, Johnson, Macy, Barrios, John, Eppensteiner, Alexander, Limkakeng, Lauren, McGowan, Tedra, Porter, Andrew, Bouffler, J. Clancy, Leahy, Bennet, deBoisblanc, Matthew, Lammi, Kyle, Happel, Paula, Lauto, Wesley, Self, Jonathan, Casey, Matthew, Semler, Sean, Collins, Frank, Harrell, Christopher, Lindsell, Todd, Rice, William, Stubblefield, Christopher, Gray, Jakea, Johnson, Megan, Roth, Margaret, Hays, Donna, Torr, Arwa, Zakaria, David, Schoenfeld, Taylor, Thompson, Douglas, Hayden, Nancy, Ringwood, Cathryn, Oldmixon, Christine, Ulysse, Richard, Morse, Ariela, Muzikansky, Laura, Fitzgerald, Samuel, Whitaker, Adrian, Lagakos, Roy, Brower, Lora, Reineck, Neil, Aggarwal, Karen, Bienstock, Michelle, Freemer, Myron, Maclawiw, Gail, Weinmann, Laurie, Morrison, Mark, Gillespie, Richard, Kryscio, Daniel, Brodie, Wojciech, Zareba, Anne, Rompalo, Michael, Boeckh, Polly, Parsons, Jason, Christie, Jesse, Hall, Nicholas, Horton, Laurie, Zoloth, Neal, Dickert, and Deborah, Diercks
- Subjects
Adult ,Male ,medicine.medical_specialty ,Randomization ,Science ,Pneumonia, Viral ,Placebo ,01 natural sciences ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,Interquartile range ,Internal medicine ,medicine ,Humans ,Treatment Failure ,030212 general & internal medicine ,0101 mathematics ,Pandemics ,Aged ,Original Investigation ,business.industry ,SARS-CoV-2 ,010102 general mathematics ,Politics ,Hydroxychloroquine ,General Medicine ,Odds ratio ,Middle Aged ,Interim analysis ,Intensive care unit ,COVID-19 Drug Treatment ,Female ,business ,medicine.drug - Abstract
Importance Data on the efficacy of hydroxychloroquine for the treatment of coronavirus disease 2019 (COVID-19) are needed. Objective To determine whether hydroxychloroquine is an efficacious treatment for adults hospitalized with COVID-19. Design, Setting, and Participants This was a multicenter, blinded, placebo-controlled randomized trial conducted at 34 hospitals in the US. Adults hospitalized with respiratory symptoms from severe acute respiratory syndrome coronavirus 2 infection were enrolled between April 2 and June 19, 2020, with the last outcome assessment on July 17, 2020. The planned sample size was 510 patients, with interim analyses planned after every 102 patients were enrolled. The trial was stopped at the fourth interim analysis for futility with a sample size of 479 patients. Interventions Patients were randomly assigned to hydroxychloroquine (400 mg twice daily for 2 doses, then 200 mg twice daily for 8 doses) (n = 242) or placebo (n = 237). Main Outcomes and Measures The primary outcome was clinical status 14 days after randomization as assessed with a 7-category ordinal scale ranging from 1 (death) to 7 (discharged from the hospital and able to perform normal activities). The primary outcome was analyzed with a multivariable proportional odds model, with an adjusted odds ratio (aOR) greater than 1.0 indicating more favorable outcomes with hydroxychloroquine than placebo. The trial included 12 secondary outcomes, including 28-day mortality. Results Among 479 patients who were randomized (median age, 57 years; 44.3% female; 37.2% Hispanic/Latinx; 23.4% Black; 20.1% in the intensive care unit; 46.8% receiving supplemental oxygen without positive pressure; 11.5% receiving noninvasive ventilation or nasal high-flow oxygen; and 6.7% receiving invasive mechanical ventilation or extracorporeal membrane oxygenation), 433 (90.4%) completed the primary outcome assessment at 14 days and the remainder had clinical status imputed. The median duration of symptoms prior to randomization was 5 days (interquartile range [IQR], 3 to 7 days). Clinical status on the ordinal outcome scale at 14 days did not significantly differ between the hydroxychloroquine and placebo groups (median [IQR] score, 6 [4-7] vs 6 [4-7]; aOR, 1.02 [95% CI, 0.73 to 1.42]). None of the 12 secondary outcomes were significantly different between groups. At 28 days after randomization, 25 of 241 patients (10.4%) in the hydroxychloroquine group and 25 of 236 (10.6%) in the placebo group had died (absolute difference, −0.2% [95% CI, −5.7% to 5.3%]; aOR, 1.07 [95% CI, 0.54 to 2.09]). Conclusions and Relevance Among adults hospitalized with respiratory illness from COVID-19, treatment with hydroxychloroquine, compared with placebo, did not significantly improve clinical status at day 14. These findings do not support the use of hydroxychloroquine for treatment of COVID-19 among hospitalized adults. Trial Registration ClinicalTrials.gov:NCT04332991
- Published
- 2020
28. Twiddler's Syndrome in Deep Brain Stimulation
- Author
-
Jason Adams and Vikram Shivkumar
- Subjects
medicine.medical_specialty ,Deep brain stimulation ,Physical medicine and rehabilitation ,Parkinson's disease ,Revealing Images ,Neurology ,business.industry ,medicine.medical_treatment ,medicine ,Twiddler's Syndrome ,Neurology (clinical) ,business ,medicine.disease - Published
- 2020
29. Roughness Augmented High Pressure Flow Boiling Heat Transfer Enhancement using LN2and LCH4on Additively Manufactured Rocket Engine Regenerative Cooling Channels
- Author
-
Mahamudur Rahman, Raul E. Palacios, Jason Adams, Ahsan Choudhuri, Gerardo Olvera, Debra Ortega, and Linda Esperanza Hernandez
- Subjects
Flow boiling heat transfer ,Regenerative cooling ,Materials science ,business.industry ,High pressure ,Nuclear engineering ,Rocket engine ,Surface finish ,business - Published
- 2020
- Full Text
- View/download PDF
30. Complications Following Orbital Floor Repair: Impact of Intraoperative Computed Tomography Scan and Implant Material
- Author
-
Jason Adams, James K. Aden, Benjamin K Walters, Samuel A. Spear, Jon Robitschek, Scott E. Bevans, Jacqueline Causbie, and John W. Lally
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Implant material ,Medicine ,Surgery ,Computed tomography ,Radiology ,business ,Orbital floor fracture ,eye diseases - Abstract
Importance: Orbital floor fracture repair is complex and postoperative complications are common. A variety of applicable surgical techniques and technologies are available to surgeons, so data abou...
- Published
- 2020
31. Plant segmentation by supervised machine learning methods
- Author
-
Jason Adams, Yuhang Xu, Yumou Qiu, and James C. Schnable
- Subjects
Computer science ,business.industry ,Segmentation ,Artificial intelligence ,business ,Machine learning ,computer.software_genre ,computer - Published
- 2020
- Full Text
- View/download PDF
32. The Effect of Surface Roughness on LCH4 Boiling Heat Transfer Performance of Conventionally and Additively Manufactured Rocket Engine Regenerative Cooling Channels
- Author
-
Linda Hernandez, Raul Palacios, Debra Ortega, Jason Adams, Luz I. Bugarin, MD Mahamudur Rahman, and Ahsan R. Choudhuri
- Subjects
Regenerative cooling ,Materials science ,business.industry ,Heat transfer ,Surface roughness ,Rocket engine ,Mechanics ,Boiling heat transfer ,business ,Liquid methane - Published
- 2019
- Full Text
- View/download PDF
33. Design and Testing of a 500 lbf Liquid Oxygen/Liquid Methane Engine
- Author
-
Manuel Herrera, Zachary Welsh, Mariana Chaidez, Luz Bugarin, Ahsan Choudhuri, Jason Adams, and Jack Chessa
- Subjects
Materials science ,Chemical engineering ,Liquid oxygen ,Liquid methane - Published
- 2019
- Full Text
- View/download PDF
34. Guideline Adherence and Hearing Outcomes of Sudden Sensorineural Hearing Loss in the Military Health System
- Author
-
Jason Adams, Carlos R Esquivel, Charlotte K Hughes, and Matthew Ryan
- Subjects
medicine.medical_specialty ,Combination therapy ,Hearing loss ,Hearing Loss, Sensorineural ,Military Health Services ,Dexamethasone ,03 medical and health sciences ,0302 clinical medicine ,Hearing ,Internal medicine ,Medicine ,Combined Modality Therapy ,Humans ,030212 general & internal medicine ,Dosing ,030223 otorhinolaryngology ,Glucocorticoids ,Retrospective Studies ,medicine.diagnostic_test ,business.industry ,Public Health, Environmental and Occupational Health ,Retrospective cohort study ,General Medicine ,Guideline ,Treatment Outcome ,Otorhinolaryngology ,Guideline Adherence ,Audiometry ,medicine.symptom ,business - Abstract
Introduction The American Academy of Otolaryngology-Head and Neck Surgery Foundation clinical practice guideline (CPG) proposes several treatment recommendations regarding sudden sensorineural hearing loss (SSNHL). The treatments for this disorder have been controversial and remain varied. We sought to determine CPG adherence and hearing outcomes of SSNHL within the Military Health System (MHS). Materials and Methods This was a retrospective case series with chart review of the MHS’s electronic medical record. Patients with SSNHL (n = 112) were treated between March 1, 2012 and September 30, 2015. Clinical improvement was defined as a 20-dB improvement in pure tone averages or a 20% increase in word recognition scores. Results Oral steroids were used in 63 (56%) patients, intratympanic (IT) steroids were utilized in 11 (10%) patients, and combination therapy was used in 38 (34%) patients. Average pure tone averages improvements with oral steroids, IT steroids, and combination therapy were 31.2 dB (95% CI, 24.4–38.0), 13.4 dB (95% CI, 0.4–29.6), and 17.3 dB (95% CI, 9.32–25.3), respectively. Average word recognition scores improvements with oral steroids, IT steroids, and combination therapy were 29.64% (95% CI, 19.5–39.7), 14.43% (95% CI, −8.32 to 45.3), and 18.48% (95% CI, 5.48–31.5), respectively. Clinical improvements with oral steroids, IT steroids, and combination therapy were 65, 46, and 50%, respectively. Conclusion The MHS is uniquely positioned to evaluate adherence to CPGs on a national and international level given the robust and standardized electronic medical record. Areas identified for improvement include more timely initiation of treatment, standardization of IT steroid dosing, more accurate coding for diagnosis and treatment, and standardization of audiology evaluation.
- Published
- 2019
35. THE COINS OF PESSINUS (2009–2011)
- Author
-
Edward Dandrow, Robert Weiland, and Jason Adams
- Published
- 2019
- Full Text
- View/download PDF
36. High-Throughput Screening of Hydrogen Peroxide (Electro)Catalysts Using Scanning Electrochemical Microscopy (SECM)
- Author
-
Yuanya Zhao, Matthew Kromer, Jason Adams, David Flaherty, and Joaquín Rodríguez-López
- Abstract
Hydrogen peroxide (H2O2) is a powerful, versatile and environmentally benign oxidant that has gained relevance in industrial settings. Direct synthesis of H2O2 from O2 and H2, which is a method with low pollution and on-site production at potentially low cost, has attracted great interest. To realize this synthetic process, catalysts of high efficiency need to be developed to facilitate the reaction. In this study, scanning electrochemical microscopy (SECM) methods were used to conduct high-throughput screening of bimetallic nanoparticle catalysts (consisting of Au, Pt, Ni, etc.) for H2O2 generation from direct synthesis. In order to achieve high-throughput analysis, samples with multiple catalysts were fabricated. We used photolithography to produce wells that confined catalyst spots of a library of materials. Gold nanoparticles (AuNPs) were dispensed into these wells with a microdispenser, leaving the same amount of AuNPs at each spot. Droplets of corresponding metal salt solutions were added into the wells and then annealed to form bimetallic catalyst spots. The morphology and composition of fabricated spot arrays were characterized with SEM, TEM and EDS. SECM measurements were performed to study the catalytic reactivity of the catalyst spots for H2O2 direct synthesis. From an electrochemical point of view, the entire process of H2O2 direct synthesis from H2 and O2 can be split into two half reactions, oxygen reduction and hydrogen oxidation. The first half reaction, oxygen reduction reaction (ORR), is a two-electron process reducing O2 into H2O2. The second half reaction, hydrogen oxidation reaction (HOR), converts H2 to protons. Only when a catalyst exhibits outstanding catalytic reactivity towards both two reactions, does it catalyze H2O2 direct synthesis efficiently in a thermocatalytic system. The catalytic reactivity for the two half reactions was investigated separately in a high throughput manner by SECM as the technique acquired information from the entire spot array in one scan and revealed catalytic performance for each spot in the array. SECM images were obtained to visualize catalytic reactivity of the spot array. Finite element analysis simulation was done in COMSOL Multiphysics to acquire theoretical values for SECM experiments. The ultimate goal of this study is to identify a catalyst of a specific composition with the best catalytic reactivity for overall H2O2 direct synthesis. Such catalyst can be used in industrial H2O2 production to improve production efficiency and to reduce cost.
- Published
- 2020
- Full Text
- View/download PDF
37. Experimental Investigation of LN2 Convection and Boiling in Traditionally and Additively Manufactured Rocket Engine Cooling Channels
- Author
-
Armando Sandoval, Enrique Gutierrez, Javier Chaparro, Luz Bugarin, Jason Adams, Ahsan R. Choudhuri, and John Melcher
- Subjects
Convection ,Materials science ,business.industry ,Boiling ,Rocket engine ,Mechanics ,business ,Communication channel - Published
- 2018
- Full Text
- View/download PDF
38. Design and Development of a 500 lbf Liquid Oxygen/Liquid Methane Engine
- Author
-
Manuel Herrera, Jack Chessa, Jason Adams, Ahsan Choudhuri, and Marissa B. Garcia
- Subjects
Materials science ,Chemical engineering ,Liquid oxygen ,Liquid methane - Published
- 2018
- Full Text
- View/download PDF
39. Ransomware and Cyber Security: the King That Did Not Wannacry
- Author
-
Jason Adams-Collman
- Subjects
Risk Management ,030206 dentistry ,General Medicine ,Radiography, Dental, Digital ,Computer security ,computer.software_genre ,03 medical and health sciences ,0302 clinical medicine ,Practice Management, Dental ,Ransomware ,Humans ,030212 general & internal medicine ,Business ,computer ,Computer Security ,Vulnerability (computing) - Abstract
A large-scale ransomware attack that affected the NHS in May 2017 caused widespread disruption and put millions of patient records at risk. How can dental practices reduce their vulnerability to the threat of a cyber attack and ensure security and safety of digitally-held patient data, such as X-rays?
- Published
- 2018
40. Developing collaborative marine turtle monitoring in the <scp>K</scp> imberley region of northern <scp>A</scp> ustralia
- Author
-
Micha V. Jackson, Jarrad Holmes, Neil Waina, Kirk Woolagoodja, Jason Adams, Jermaine Umbagai, Francis Woolagoodja, Rod Kennett, Leonie Cheinmora, Peter Bayliss, Tom Vigilante, Edmund Jungine, Frank Weisenberger, and Robert Warren
- Subjects
Conservation planning ,business.industry ,Environmental resource management ,Biodiversity ,Context (language use) ,Management, Monitoring, Policy and Law ,Indigenous ,law.invention ,Geography ,Environmental protection ,law ,Northern australia ,Wildlife management ,Collaborative partnership ,Turtle (robot) ,business ,Ecology, Evolution, Behavior and Systematics ,Nature and Landscape Conservation - Abstract
Contemporary land and sea management – driven by community-based planning and informed by traditional and local knowledge and scientific research – can significantly improve both biodiversity and cultural outcomes. Here, we describe the context and process of developing a boat-based survey approach to marine turtle monitoring by Indigenous rangers using a collaborative partnership model that supports Traditional Owner aspirations and conservation objectives.
- Published
- 2015
- Full Text
- View/download PDF
41. Influence of design and operation parameters in the organic load and nutrient removal in constructed wetlands
- Author
-
Jason Adams Hale, Joan García Serrano, Universitat Politècnica de Catalunya. Doctorat en Enginyeria Ambiental, Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, and Universitat Politècnica de Catalunya. GEMMA - Grup d'Enginyeria i Microbiologia del Medi Ambient
- Subjects
Biogeochemical cycle ,geography ,geography.geographical_feature_category ,Enginyeria civil::Geologia::Hidrologia [Àrees temàtiques de la UPC] ,Constructed wetlands ,business.industry ,Environmental resource management ,Zones humides artificials ,Desenvolupament humà i sostenible::Enginyeria ambiental::Tractament de l'aigua [Àrees temàtiques de la UPC] ,Biomass ,Wetland ,Reuse ,Ecological engineering ,Sustainable sanitation ,Nutrient ,Environmental science ,Sewage treatment ,business - Abstract
This chapter discusses the principal processes, constraints, and design and operation parameters which control organic load and nutrient removal in the basic types of constructed wetlands (CW). While many physical processes act and interact to reduce and remove pollutants from wastewater, many of the nutrient and organic matter removal effects of CWs are dominated or influenced by microbial activity. The main mechanisms for dissolved organic matter removal from wastewater streams are off-gassing of metabolic products such as CO2 and CH4. Aerobic transformation consumes organic matter in the presence of molecular oxygen producing carbon dioxide, water, and energy. Biodegradable organic matter, nitrogen, and phosphorus are common wastewater contaminants which must be addressed by treatment systems before re-use or discharge back to the environment. The net removal of contaminants is the sum of many processes, including sedimentation, filtration, precipitation, volatilization, adsorption, plant uptake, and various microbial processes influencing carbon, nitrogen, and phosphorus cycles, among others. M. Hartl provided comments to this manuscript. Mr. Hartl is a PhD Fellow in the SuPER-W “European Joint Doctorate” programme at UPC Barcelona and Ghent University. His project, titled “Coupling bio-electrochemical systems and phytotechnologies for wastewater treatment used in rural areas towards economic recovery of (micro)nutrients, biomass & water reuse” integrates several themes within the discipline of ecological engineering, especially constructed wetlands and bio-electrochemical systems; sustainable sanitation; and other application of the study of biogeochemical cycles.
- Published
- 2018
42. Assessing Active Labour-Market Programs: How Effective Is Ontario Works?
- Author
-
Jason Adams, Ken Chow, and David Rose
- Published
- 2018
- Full Text
- View/download PDF
43. The Constellation of Opposition
- Author
-
Jason Adams
- Published
- 2017
- Full Text
- View/download PDF
44. Diffusion Tensor Imaging Parameter Obtained during Acute Blunt Cervical Spinal Cord Injury in Predicting Long-Term Outcome
- Author
-
Catriona Miller, Jaichen Zhuo, Bizhan Aarabi, Stuart E. Mirvis, Kathirkamanathan Shanmuganathan, Jay Menakar, Jason Adams, Hegang Chen, and Rao P. Gullapalli
- Subjects
Adult ,Male ,Longitudinal study ,Time Factors ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Blunt ,Image Interpretation, Computer-Assisted ,Medicine ,Humans ,In patient ,Longitudinal Studies ,Prospective Studies ,Spinal cord injury ,Spinal Cord Injuries ,Aged ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,Recovery of Function ,Middle Aged ,Spinal cord ,medicine.disease ,Prognosis ,medicine.anatomical_structure ,Diffusion Tensor Imaging ,Anesthesia ,Cervical spinal cord injury ,Cervical Vertebrae ,Female ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,Diffusion MRI - Abstract
There are no reliable neuroimaging biomarkers to predict long-term outcome after spinal cord injury. This prospective longitudinal study evaluates diffusion tensor imaging (DTI) in predicting long-term outcome after cervical spinal cord injury (CSCI). We investigate the admission DTI parameters measured in 30 patients with CSCI, with 16 of them followed up to one year, and 15 volunteers serving as controls. All magnetic resonance imaging examinations were performed within 24 h of injury. The DTI parameters were measured in patients and controls, avoiding areas of hemorrhage in patients and at corresponding upper/middle/lower regions of the spinal cord in controls. Stepwise regression analysis was performed to find relevant parameters (normalized DTI values, age, sex, hemorrhagic contusion [HC or non-HC]) that correlated with two primary outcome measures: patient International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) motor and Spinal Cord Independence Measure (SCIM III) scores at one year. Among all DTI measures, axial diffusivity (AD) most strongly correlated with both motor (r
- Published
- 2017
45. Influence of design and operation parameters in the organic load and nutrient removal in constructed wetlands
- Author
-
Universitat Politècnica de Catalunya. Doctorat en Enginyeria Ambiental, Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, Universitat Politècnica de Catalunya. GEMMA - Grup d'Enginyeria i Microbiologia del Medi Ambient, Hale, Jason Adams, García Serrano, Joan, Universitat Politècnica de Catalunya. Doctorat en Enginyeria Ambiental, Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, Universitat Politècnica de Catalunya. GEMMA - Grup d'Enginyeria i Microbiologia del Medi Ambient, Hale, Jason Adams, and García Serrano, Joan
- Abstract
This chapter discusses the principal processes, constraints, and design and operation parameters which control organic load and nutrient removal in the basic types of constructed wetlands (CW). While many physical processes act and interact to reduce and remove pollutants from wastewater, many of the nutrient and organic matter removal effects of CWs are dominated or influenced by microbial activity. The main mechanisms for dissolved organic matter removal from wastewater streams are off-gassing of metabolic products such as CO2 and CH4. Aerobic transformation consumes organic matter in the presence of molecular oxygen producing carbon dioxide, water, and energy. Biodegradable organic matter, nitrogen, and phosphorus are common wastewater contaminants which must be addressed by treatment systems before re-use or discharge back to the environment. The net removal of contaminants is the sum of many processes, including sedimentation, filtration, precipitation, volatilization, adsorption, plant uptake, and various microbial processes influencing carbon, nitrogen, and phosphorus cycles, among others., M. Hartl provided comments to this manuscript. Mr. Hartl is a PhD Fellow in the SuPER-W “European Joint Doctorate” programme at UPC Barcelona and Ghent University. His project, titled “Coupling bio-electrochemical systems and phytotechnologies for wastewater treatment used in rural areas towards economic recovery of (micro)nutrients, biomass & water reuse” integrates several themes within the discipline of ecological engineering, especially constructed wetlands and bio-electrochemical systems; sustainable sanitation; and other application of the study of biogeochemical cycles., Peer Reviewed, Postprint (published version)
- Published
- 2018
46. Structural Variations in Articular Cartilage Matrix Are Associated with Early-Onset Osteoarthritis in the Spondyloepiphyseal Dysplasia Congenita (Sedc) Mouse
- Author
-
Shaela A. Avery, Christopher R. Cunningham, David W. Macdonald, Ryan S. Squires, Jason Adams, Nicholas B. Heimann, Melissa Baker, Robert E. Seegmiller, and David L. Kooyman
- Subjects
Cartilage, Articular ,Pathology ,spondyloepiphyseal dysplasia congenita (sedc) ,Dwarfism ,Osteoarthritis ,Matrix (biology) ,lcsh:Chemistry ,Extracellular matrix ,Mice ,0302 clinical medicine ,proteoglycan ,animal model of osteoarthritis ,Col2a1 ,type II collagen ,articular cartilage ,extracellular matrix ,lcsh:QH301-705.5 ,Spectroscopy ,0303 health sciences ,Chemistry ,General Medicine ,Computer Science Applications ,medicine.anatomical_structure ,Spondyloepiphyseal dysplasia congenita ,musculoskeletal diseases ,medicine.medical_specialty ,Type II collagen ,Mice, Transgenic ,Osteochondrodysplasias ,Article ,Catalysis ,Chondrocyte ,Inorganic Chemistry ,03 medical and health sciences ,Chondrocytes ,medicine ,Animals ,Physical and Theoretical Chemistry ,Collagen Type II ,Molecular Biology ,030304 developmental biology ,Cartilage ,Organic Chemistry ,medicine.disease ,lcsh:Biology (General) ,lcsh:QD1-999 ,030217 neurology & neurosurgery - Abstract
Heterozgyous spondyloepiphyseal dysplasia congenita (sedc/+) mice expressing a missense mutation in col2a1 exhibit a normal skeletal morphology but early-onset osteoarthritis (OA). We have recently examined knee articular cartilage obtained from homozygous (sedc/sedc) mice, which express a Stickler-like phenotype including dwarfism. We examined sedc/sedc mice at various levels to better understand the mechanistic process resulting in OA. Mutant sedc/sedc, and control (+/+) cartilages were compared at two, six and nine months of age. Tissues were fixed, decalcified, processed to paraffin sections, and stained with hematoxylin/eosin and safranin O/fast green. Samples were analyzed under the light microscope and the modified Mankin and OARSI scoring system was used to quantify the OA-like changes. Knees were stained with 1C10 antibody to detect the presence and distribution of type II collagen. Electron microscopy was used to study chondrocyte morphology and collagen fibril diameter. Compared with controls, mutant articular cartilage displayed decreased fibril diameter concomitant with increases in size of the pericellular space, Mankin and OARSI scores, cartilage thickness, chondrocyte clustering, proteoglycan staining and horizontal fissuring. In conclusion, homozygous sedc mice are subject to early-onset knee OA. We conclude that collagen in the mutant's articular cartilage (both heterozygote and homozygote) fails to provide the normal meshwork required for matrix integrity and overall cartilage stability.
- Published
- 2013
- Full Text
- View/download PDF
47. The Speeds of Ambiguity: An Interview with Paul Virilio
- Author
-
Jason Adams
- Subjects
Cultural Studies ,History ,Psychoanalysis ,Literature and Literary Theory ,Sociology and Political Science ,media_common.quotation_subject ,Ambiguity ,Sociology ,Social psychology ,media_common - Abstract
This interview was conducted on the assumption that for all their seeming pessimism, Virilio's technocultural writings are more productively understood as a “Dionysian yes” than as a simple assertion of the no as such. In other words, they presuppose that the specificity of his thought derives not from “the political” itself (as it is explicitly stated) but from the aesthetic as itself political. The interview considers the extent to which Virilio in Deleuze's terms, “has placed the negative at the service of the power of affirming,” even though he has done so in a subterranean manner that largely remains unnoticed by most of his commentators. The assumption that his concept of speed is unidimensional, that he conceives no alternative to the contemporary technoscientific order, and that all forms of mass culture are denounced as equally complicit with late modern power are thus destabilized with the first several questions. Similarly, the notion that Virilio holds that the manipulation of emotion negates democratic possibility as such, that citizenship is entirely incompatible with globalization, and that the only option in our time is to either entirely converge virtual and actual reality or to abandon one in favor of the other are complicated in the remaining ones. Overall, the interview suggests that Virilio himself must be considered as a vector whose concepts are always already in motion, indeed as one who may seem to be making a definitive statement at one moment, but who complicates that very assumption at another. Thus, while the many criticisms of his work are certainly formidable, it seeks to show that they can never adequately represent the composite nature of his thought itself, even when they go to great pains to avoid the suppression of ambiguity.
- Published
- 2010
- Full Text
- View/download PDF
48. Brief Report: Abnormal Association Between the Thalamus and Brain Size in Asperger’s Disorder
- Author
-
Nancy J. Minshew, Jason Adams, Matcheri S. Keshavan, Ragy R. Girgis, Antonio Y. Hardan, Nadine M. Melhem, and Andrew R. Gilbert
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Central nervous system ,Thalamus ,Audiology ,Reference Values ,Image Processing, Computer-Assisted ,Developmental and Educational Psychology ,medicine ,Humans ,Language Development Disorders ,Asperger Syndrome ,Autistic Disorder ,Child ,Association (psychology) ,Brain ,medicine.disease ,Magnetic Resonance Imaging ,Developmental disorder ,medicine.anatomical_structure ,Asperger syndrome ,Brain size ,Asperger's disorder ,Autism ,Female ,Psychology ,Neuroscience - Abstract
The objective of this study was to examine the relationship between thalamic volume and brain size in individuals with Asperger's disorder (ASP). Volumetric measurements of the thalamus were performed on MRI scans obtained from 12 individuals with ASP (age range: 10-35 years) and 12 healthy controls (age range: 9-33 years). A positive correlation was found between total brain volume and thalamic size in controls, but not in ASP subjects. This occurred in the absence of differences in mean thalamic volumes between the study groups. Findings from this investigation point to an abnormal relationship between the thalamus and its projection areas in ASP and are consistent with similar studies in autism, supporting that these disorders are qualitatively similar and possibly quantitatively different.
- Published
- 2007
- Full Text
- View/download PDF
49. Synthesis and Structural Characterization of Potassium Salts of Phosphane‐Substituted (Cyclopentadienyl)iron Dicyanides, and Their Use as Bridging Ligands for Copper( <scp>I</scp> ) Phosphane Derivatives
- Author
-
Andrea L. Phelps, Jason C. Yarbrough, M. Jason Adams, and Donald J. Darensbourg
- Subjects
Infrared ,Cyanide ,Potassium ,Decarbonylation ,chemistry.chemical_element ,Photochemistry ,Medicinal chemistry ,Copper ,Inorganic Chemistry ,chemistry.chemical_compound ,chemistry ,Cyclopentadienyl complex ,Diphosphane ,Acetonitrile - Abstract
Phosphane-substituted CpFe(CN)2 anions have been synthesized by photochemical decarbonylation of KCpFe(CN)2CO in the presence of various mono- and diphosphanes. The synthesis and characterization of uniquely bridged diphosphane derivatives, [KCpFe(CN)2]2-μ-(Ph2P)2−(CH2)n (n = 2−4), are particularly noteworthy. These phosphane-substituted CpFe(CN)2− units have afforded stable mixed-metal complexes upon reaction with CuI in the presence of tricyclohexylphosphane in acetonitrile solution. X-ray crystallography shows these derivatives to display two-dimensional diamond-shaped structures with copper(I) of the form [Fe(CN)2Cu]2, where the CuI centers exhibit both trigonal and tetrahedral geometries. Infrared data reveal that the withdrawal of electron density from the iron centers in these mixed metal cyanides via the cyanide ligands is enhanced upon replacing CO in CpFe(CN)2CO− with phosphanes. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)
- Published
- 2003
- Full Text
- View/download PDF
50. Anti-globalization: The Global Fight for Local Autonomy
- Author
-
Amory Starr and Jason Adams
- Subjects
Local autonomy ,Politics ,Globalization ,Sociology and Political Science ,Range (biology) ,Political economy ,Sociology ,Social science - Abstract
This paper examines one of the less-discussed modes of anti-globalization, relocalization or local autonomy. It describes a range of autonomous movements, summarizes their political economic ideas, and discusses some common social critiques raised in regard to local autonomy.
- Published
- 2003
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.