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1. EP65 Mechanical thrombectomies, initial experiences from Kosovo Case series presentation

Author: Gjikolli, B, primary, Kalousek, V, additional, Culo, B, additional, Murati, M, additional, Bejta, I, additional, Shatri, J, additional, Shala, N, additional, Dedushi, K, additional, Jashari, F, additional, Pasha, F, additional, Komoni, E, additional, Boshnjaku, D, additional, Myftiu, B, additional, Jaha, L, additional, Kuçi, A, additional, Miftari, R, additional, Govori, V, additional, Bulja, D, additional, and Vegar, S, additional
Published: 2021
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2. Poster session 3: Thursday 4 December 2014, 14: 00–18: 00Location: Poster area

Author: Bajraktari, G, Ronn, F, Ibrahimi, P, Jashari, F, Jensen, SM, and Henein, MY
Published: 2014

3. Club 35 Poster session 2: Thursday 4 December 2014, 08: 30–18: 00Location: Poster area

Author: Ibrahimi, P, Jashari, F, Johansson, E, Gronlund, C, Bajraktari, G, Wester, P, and Henein, MY
Published: 2014

4. Club 35 Poster session 1: Wednesday 3 December 2014, 09: 00–16: 00Location: Poster area

Author: Jashari, F, Ibrahimi, P, Johansson, E, Gronlund, C, Bajraktari, G, Wester, P, and Henein, MY
Published: 2014

5. Total isovolumic time, a marker of global left ventricular dyssynchrony, predicts response to Cardiac Resynchronization Therapy in heart failure patients with atrial fibrillation: P283

Author: Bajraktari, G, Ronn, F, Ibrahimi, P, Jashari, F, Jensen, S M, and Henein, M Y
Published: 2014

6. Poster session Friday 13 December - AM: 13/12/2013, 08: 30–12: 30Location: Poster area

Author: Ibrahimi, P, Bajraktari, G, Poniku, A, Hysenaj, V, Ahmeti, A, Jashari, F, Haliti, E, and Henein, MY
Published: 2013

7. Poster session Wednesday 11 December all day display: 11/12/2013, 09: 30–16: 00Location: Poster area

Author: Ibrahimi, P, Jashari, F, Johansson, E, Gronlund, C, Bajraktari, G, Wester, P, and Henein, MY
Published: 2013

8. P760Indirect markers of left ventricular dyssynchrony, but not ejection fraction, are related to exercise capacity in systolic heart failure

Author: Ibrahimi, P, Bajraktari, G, Jashari, F, Ahmeti, A, Poniku, A, Haliti, E, and Henein, M
Published: 2011

9. 2016 European Guidelines on cardiovascular disease prevention in clinical practice The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts) Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR)

Author: Piepoli MF, Hoes AW, Agewall S, Albus C, Brotons C, Catapano AL, Cooney MT, Corrà U, Cosyns B, Deaton C, Graham I, Hall MS, Hobbs FDR, Løchen ML, Löllgen H, Marques-Vidal P, Perk J, Prescott E, Redon J, Richter DJ, Sattar N, Smulders Y, Tiberi M, van der Worp HB, van Dis I, Verschuren WMM1, Binno S, De Backer G, Roffi M, Aboyans V, Bachl N, Bueno H, Carerj S, Cho L, Cox J, De Sutter J, Egidi G, Fisher M, Fitzsimons D, Franco OH, Guenoun M, Jennings C, Jug B, Kirchhof P, Kotseva K, Lip GY, Mach F, Mancia G, Bermudo FM, Mezzani A, Niessner A, Ponikowski P, Rauch B, Rydén L, Stauder A, Turc G, Wiklund O, Windecker S, Zamorano JL, Achenbach S, Badimon L, Barón-Esquivias G, Baumgartner H, Bax JJ, Dean V, Erol Ç, Gaemperli O, Kolh P, Lancellotti P, Nihoyannopoulos P, Torbicki A, Vaz Carneiro A, Metzler B, Najafov R, Stelmashok V, De Maeyer C, Dilic M, Gruev I, Milicic D, Vaverkova H, Gustafsson I, Attia I, Duishvili D, Kostova N, Ferrières J, Klimiashvili Z, Hambrecht R, Tsioufis K, Szabados E, Andersen K, Vaughan C, Zafrir B, Novo S, Davletov K, Jashari F, Kerimkulova A, Mintale I, Saade G, Petrulioniene Z, Delagardelle C, Magri CJ, Rudi V, Oukerraj L, Çölkesen BE, Schirmer H, Jankowski P, Dos Reis RP, Gherasim D, Nedogoda S, Zavatta M, Giga V, Filipova S, Padial LR, Kiessling A, Mahdhaoui A, Ural D, Nesukay E, Gale C., Internal medicine, ICaR - Circulation and metabolism, Piepoli MF, Hoes AW, Agewall S, Albus C, Brotons C, Catapano AL, Cooney MT, Corrà U, Cosyns B, Deaton C, Graham I, Hall MS, Hobbs FDR, Løchen ML, Löllgen H, Marques-Vidal P, Perk J, Prescott E, Redon J, Richter DJ, Sattar N, Smulders Y, Tiberi M, van der Worp HB, van Dis I, Verschuren WMM1, Binno S, De Backer G, Roffi M, Aboyans V, Bachl N, Bueno H, Carerj S, Cho L, Cox J, De Sutter J, Egidi G, Fisher M, Fitzsimons D, Franco OH, Guenoun M, Jennings C, Jug B, Kirchhof P, Kotseva K, Lip GY, Mach F, Mancia G, Bermudo FM, Mezzani A, Niessner A, Ponikowski P, Rauch B, Rydén L, Stauder A, Turc G, Wiklund O, Windecker S, Zamorano JL, Zamorano JL, Aboyans V, Achenbach S, Agewall S, Badimon L, Barón-Esquivias G, Baumgartner H, Bax JJ, Bueno H, Carerj S, Dean V, Erol Ç, Fitzsimons D, Gaemperli O, Kirchhof P, Kolh P, Lancellotti P, Lip GY, Nihoyannopoulos P, Piepoli MF, Ponikowski P, Roffi M, Torbicki A, Vaz Carneiro A, Windecker S, Metzler B, Najafov R, Stelmashok V, De Maeyer C, Dilic M, Gruev I, Milicic D, Vaverkova H, Gustafsson I, Attia I, Duishvili D, Kostova N, Ferrières J, Klimiashvili Z, Hambrecht R, Tsioufis K, Szabados E, Andersen K, Vaughan C, Zafrir B, Novo S, Davletov K, Jashari F, Kerimkulova A, Mintale I, Saade G, Petrulioniene Z, Delagardelle C, Magri CJ, Rudi V, Oukerraj L, Çölkesen BE, Schirmer H, Jankowski P, Dos Reis RP, Gherasim D, Nedogoda S, Zavatta M, Giga V, Filipova S, Padial LR, Kiessling A, Mach F, Mahdhaoui A, Ural D, Nesukay E, Gale C., Cardio-vascular diseases, and Clinical sciences
Subjects: Cost-Benefit Analysis, General Practice, 030204 cardiovascular system & hematology, Guideline, Diabete, 0302 clinical medicine, Hyperlipidemia, Stakeholder, Medicine, 030212 general & internal medicine, Multiple Chronic Conditions, Practice Patterns, Physicians', Societies, Medical, Risk assessment, education.field_of_study, Cardiac Rehabilitation, Diabetes, Rehabilitation, Smoking, Psychosocial factor, Age Factors, Lipid, Middle Aged, Primary care, Pedigree, Europe, Cardiovascular Diseases, Psychosocial factors, Hypertension, Blood pressure, Diet, Healthy, Cardiology and Cardiovascular Medicine, Adult, Diagnostic Imaging, medicine.medical_specialty, Ambulatory blood pressure, Population, Cardiology, Healthy lifestyle, Hyperlipidemias, Health Promotion, Diabetic angiopathy, Guidelines, Risk Assessment, 03 medical and health sciences, Sex Factors, Diabetes mellitus, Journal Article, Humans, Clinical settings, Healthy Lifestyle, Intensive care medicine, education, Exercise, Antihypertensive Agents, Nutrition, Aged, business.industry, Vascular disease, Physical activity, Prevention, medicine.disease, body regions, Clinical setting, Risk management, Socioeconomic Factors, Smoking Cessation, Joint Esc Guidelines, business, Biomarkers, Diabetic Angiopathies
Abstract: ABI : ankle–brachial (blood pressure) index ABPM : ambulatory blood pressure monitoring ACCORD : Action to Control Cardiovascular Risk in Diabetes ACE-I : angiotensin-converting enzyme inhibitor ACS : acute coronary syndromes ADVANCE : Action in Diabetes and Vascular disease: PreterAx
Published: 2016
Full Text: View/download PDF

10. 2016 European Guidelines on cardiovascular disease prevention in clinical practice

Author: Piepoli, MF, Hoes, AW, Agewall, S, Albus, C, Brotons, C, Catapano, AL, Cooney, MT, Corrà, U, Cosyns, B, Deaton, C, Graham, I, Hall, MS, Hobbs, FDR, Løchen, ML, Löllgen, H, Marques-Vidal, P, Perk, J, Prescott, E, Redon, J, Richter, DJ, Sattar, N, Smulders, Y, Tiberi, M, Van Der Worp, HB, Van Dis, I, Verschuren, WM M, Binno, S, De Backer, G, Roffi, M, Aboyans, V, Bachl, N, Carerj, S, Cho, Le, Cox, J, De Sutter, J, Egidi, G, Fisher, M, Fitzsimons, D, Franco, OH, Guenoun, M, Jennings, C, Jug, B, Kirchhof, P, Kotseva, K, Lip, GYH, Mach, F, Mancia, G, Bermudo, FM, Mezzani, A, Niessner, A, Ponikowski, P, Rauch, B, Stauder, A, Turc, G, Wiklund, O, Windecker, S, Zamorano, JL, Achenbach, S, Badimon, L, Barón-Esquivias, G, Baumgartner, H, Bax, JJ, Dean, V, Erol, Ç, Gaemperli, O, Kolh, P, Lancellotti, P, Nihoyannopoulos, P, Torbicki, A, Carneiro, AV, Metzler, B, Najafov, R, Stelmashok, V, De Maeyer, C, Dilić, M, Gruev, I, Miličić, D, Vaverkova, H, Gustafsson, I, Attia, I, Duishvili, D, Ferrières, J, Kostova, N, Klimiashvili, Z, Hambrecht, R, Tsioufis, K, Szabados, E, Andersen, K, Vaughan, C, Zafrir, B, Novo, S, Davletov, K, Jashari, F, Kerimkulova, A, Mintale, I, Saade, G, Petrulioniene, Z, Delagardelle, C, Magri, CJ, Rudi, V, Oukerraj, L, Çölkesen, BE, Schirmer, H, Dos Reis, RP, Gherasim, D, Nedogoda, S, Zavatta, M, Giga, V, Filipova, S, Padial, LR, Kiessling, A, Mahdhaoui, A, Ural, D, Nesukay, E, Gale, C, Piepoli, M, Hoes, A, Agewall, S, Albus, C, Brotons, C, Catapano, A, Cooney, M, Corrà, U, Cosyns, B, Deaton, C, Graham, I, Hall, M, Hobbs, F, Løchen, M, Löllgen, H, Marques-Vidal, P, Perk, J, Prescott, E, Redon, J, Richter, D, Sattar, N, Smulders, Y, Tiberi, M, Van Der Worp, H, Van Dis, I, Verschuren, W, Binno, S, De Backer, G, Roffi, M, Aboyans, V, Bachl, N, Carerj, S, Cho, L, Cox, J, De Sutter, J, Egidi, G, Fisher, M, Fitzsimons, D, Franco, O, Guenoun, M, Jennings, C, Jug, B, Kirchhof, P, Kotseva, K, Lip, G, Mach, F, Mancia, G, Bermudo, F, Mezzani, A, Niessner, A, Ponikowski, P, Rauch, B, Stauder, A, Turc, G, Wiklund, O, Windecker, S, Zamorano, J, Achenbach, S, Badimon, L, Barón-Esquivias, G, Baumgartner, H, Bax, J, Dean, V, Erol, Ç, Gaemperli, O, Kolh, P, Lancellotti, P, Nihoyannopoulos, P, Torbicki, A, Carneiro, A, Metzler, B, Najafov, R, Stelmashok, V, De Maeyer, C, Dilić, M, Gruev, I, Miličić, D, Vaverkova, H, Gustafsson, I, Attia, I, Duishvili, D, Ferrières, J, Kostova, N, Klimiashvili, Z, Hambrecht, R, Tsioufis, K, Szabados, E, Andersen, K, Vaughan, C, Zafrir, B, Novo, S, Davletov, K, Jashari, F, Kerimkulova, A, Mintale, I, Saade, G, Petrulioniene, Z, Delagardelle, C, Magri, C, Rudi, V, Oukerraj, L, Çölkesen, B, Schirmer, H, Dos Reis, R, Gherasim, D, Nedogoda, S, Zavatta, M, Giga, V, Filipova, S, Padial, L, Kiessling, A, Mahdhaoui, A, Ural, D, Nesukay, E, and Gale, C
Subjects: Adult, Diagnostic Imaging, Diabetic Angiopathie, Healthy Diet, General Practice, Population, Healthy lifestyle, Health Promotion, Sex Factor, Guideline, Guidelines, Diabete, Socioeconomic Factor, Blood pressure, Clinical settings, Diabetes, Lipid, Nutrition, Physical activity, Prevention, Primary care, Psychosocial factors, Rehabilitation, Risk assessment, Risk management, Smoking, Stakeholder, Cardiology and Cardiovascular Medicine, Cardiovascular Disease, Age Factor, Cost-Benefit Analysi, Practice Patterns, Physicians', Exercise, Aged, Cardiac Rehabilitation, Psychosocial factor, Biomarker, Middle Aged, Multiple Chronic Condition, Pedigree, Clinical setting, Antihypertensive Agent, Hyperlipidemia, Hypertension, Smoking Cessation, Human
Published: 2016

11. 2016 European Guidelines on cardiovascular disease prevention in clinical practice

Author: Piepoli, M, Hoes, A, Agewall, S, Albus, C, Brotons, C, Catapano, A, Cooney, M, Corrà, U, Cosyns, B, Deaton, C, Graham, I, Hall, M, Hobbs, F, Løchen, M, Löllgen, H, Marques-Vidal, P, Perk, J, Prescott, E, Redon, J, Richter, D, Sattar, N, Smulders, Y, Tiberi, M, Van Der Worp, H, Van Dis, I, Verschuren, W, Binno, S, De Backer, G, Roffi, M, Aboyans, V, Bachl, N, Carerj, S, Cho, L, Cox, J, De Sutter, J, Egidi, G, Fisher, M, Fitzsimons, D, Franco, O, Guenoun, M, Jennings, C, Jug, B, Kirchhof, P, Kotseva, K, Lip, G, Mach, F, Mancia, G, Bermudo, F, Mezzani, A, Niessner, A, Ponikowski, P, Rauch, B, Stauder, A, Turc, G, Wiklund, O, Windecker, S, Zamorano, J, Achenbach, S, Badimon, L, Barón-Esquivias, G, Baumgartner, H, Bax, J, Dean, V, Erol, Ç, Gaemperli, O, Kolh, P, Lancellotti, P, Nihoyannopoulos, P, Torbicki, A, Carneiro, A, Metzler, B, Najafov, R, Stelmashok, V, De Maeyer, C, Dilić, M, Gruev, I, Miličić, D, Vaverkova, H, Gustafsson, I, Attia, I, Duishvili, D, Ferrières, J, Kostova, N, Klimiashvili, Z, Hambrecht, R, Tsioufis, K, Szabados, E, Andersen, K, Vaughan, C, Zafrir, B, Novo, S, Davletov, K, Jashari, F, Kerimkulova, A, Mintale, I, Saade, G, Petrulioniene, Z, Delagardelle, C, Magri, C, Rudi, V, Oukerraj, L, Çölkesen, B, Schirmer, H, Dos Reis, R, Gherasim, D, Nedogoda, S, Zavatta, M, Giga, V, Filipova, S, Padial, L, Kiessling, A, Mahdhaoui, A, Ural, D, Nesukay, E, Gale, C, Piepoli, MF, Hoes, AW, Catapano, AL, Cooney, MT, Hall, MS, Hobbs, FDR, Løchen, ML, Richter, DJ, Van Der Worp, HB, Verschuren, WM M, Cho, Le, Franco, OH, Lip, GYH, Bermudo, FM, Zamorano, JL, Bax, JJ, Carneiro, AV, Magri, CJ, Çölkesen, BE, Dos Reis, RP, Padial, LR, Piepoli, M, Hoes, A, Agewall, S, Albus, C, Brotons, C, Catapano, A, Cooney, M, Corrà, U, Cosyns, B, Deaton, C, Graham, I, Hall, M, Hobbs, F, Løchen, M, Löllgen, H, Marques-Vidal, P, Perk, J, Prescott, E, Redon, J, Richter, D, Sattar, N, Smulders, Y, Tiberi, M, Van Der Worp, H, Van Dis, I, Verschuren, W, Binno, S, De Backer, G, Roffi, M, Aboyans, V, Bachl, N, Carerj, S, Cho, L, Cox, J, De Sutter, J, Egidi, G, Fisher, M, Fitzsimons, D, Franco, O, Guenoun, M, Jennings, C, Jug, B, Kirchhof, P, Kotseva, K, Lip, G, Mach, F, Mancia, G, Bermudo, F, Mezzani, A, Niessner, A, Ponikowski, P, Rauch, B, Stauder, A, Turc, G, Wiklund, O, Windecker, S, Zamorano, J, Achenbach, S, Badimon, L, Barón-Esquivias, G, Baumgartner, H, Bax, J, Dean, V, Erol, Ç, Gaemperli, O, Kolh, P, Lancellotti, P, Nihoyannopoulos, P, Torbicki, A, Carneiro, A, Metzler, B, Najafov, R, Stelmashok, V, De Maeyer, C, Dilić, M, Gruev, I, Miličić, D, Vaverkova, H, Gustafsson, I, Attia, I, Duishvili, D, Ferrières, J, Kostova, N, Klimiashvili, Z, Hambrecht, R, Tsioufis, K, Szabados, E, Andersen, K, Vaughan, C, Zafrir, B, Novo, S, Davletov, K, Jashari, F, Kerimkulova, A, Mintale, I, Saade, G, Petrulioniene, Z, Delagardelle, C, Magri, C, Rudi, V, Oukerraj, L, Çölkesen, B, Schirmer, H, Dos Reis, R, Gherasim, D, Nedogoda, S, Zavatta, M, Giga, V, Filipova, S, Padial, L, Kiessling, A, Mahdhaoui, A, Ural, D, Nesukay, E, Gale, C, Piepoli, MF, Hoes, AW, Catapano, AL, Cooney, MT, Hall, MS, Hobbs, FDR, Løchen, ML, Richter, DJ, Van Der Worp, HB, Verschuren, WM M, Cho, Le, Franco, OH, Lip, GYH, Bermudo, FM, Zamorano, JL, Bax, JJ, Carneiro, AV, Magri, CJ, Çölkesen, BE, Dos Reis, RP, and Padial, LR
Published: 2016

12. Carotid plaque echogenicity predicts cerebrovascular symptoms: a systematic review and meta-analysis

Author: Jashari, F., primary, Ibrahimi, P., additional, Bajraktari, G., additional, Grönlund, C., additional, Wester, P., additional, and Henein, M. Y., additional
Published: 2016
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13. Carotid IM-GSM is related to multisite atherosclerosis disease

Author: Jashari, F., primary, Ibrahimi, P., additional, Johansson, E., additional, Gronlund, C., additional, Wester, P., additional, and Henein, M.Y., additional
Published: 2015
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14. Common carotid intima-media measurements determine distal disease structure and vulnerability in asymptomatic patients

Author: Ibrahimi, P., primary, Jashari, F., additional, Johansson, E., additional, Gronlund, C., additional, Wester, P., additional, and Henein, M.Y., additional
Published: 2015
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15. Club 35 Poster session 2: Thursday 4 December 2014, 08:30-18:00 * Location: Poster area

Author: Santos, M., primary, Rivero, J., additional, Mccullough, S., additional, Opotowsky, A., additional, Waxman, A., additional, Systrom, D., additional, Shah, A., additional, Santoro, C., additional, Esposito, R., additional, Schiano Lomoriello, V., additional, Raia, R., additional, De Palma, D., additional, Ippolito, R., additional, Ierano, P., additional, Arpino, G., additional, De Simone, G., additional, Galderisi, M., additional, Cameli, M., additional, Lisi, M., additional, Di Tommaso, C., additional, Solari, M., additional, Focardi, M., additional, Maccherini, M., additional, Henein, M., additional, Mondillo, S., additional, Simova, I., additional, Katova, T., additional, Pauncheva, B., additional, Vrettos, A., additional, Dawson, D., additional, Grigoratos, C., additional, Papapolychroniou, C., additional, Nihoyannopoulos, P., additional, Voilliot, D., additional, Huttin, O., additional, Vaugrenard, T., additional, Venner, C., additional, Sadoul, N., additional, Aliot, E., additional, Juilliere, Y., additional, Selton-Suty, C., additional, Hamdi, I., additional, Mahfoudhi, H., additional, Ben Mansour, N., additional, Dahmani, R., additional, Lahidheb, D., additional, Fehri, W., additional, Haouala, H., additional, Erken Pamukcu, H., additional, Gerede, D., additional, Sorgun, M., additional, Akbostanci, C., additional, Turhan, S., additional, Erol, u., additional, Magne, J., additional, Dulgheru, R., additional, Kou, S., additional, Henri, C., additional, Caballero, L., additional, De Sousa, C., additional, Sprynger, M., additional, Pierard, L., additional, Lancellotti, P., additional, Panelo, M. L., additional, Rodriguez-Fernandez, A., additional, Escriba-Bori, S., additional, Krol, W., additional, Konopka, M., additional, Burkhard, K., additional, Jedrzejewska, I., additional, Pokrywka, A., additional, Klusiewicz, A., additional, Chwalbinska, J., additional, Dluzniewski, M., additional, Braksator, W., additional, Elmissiri, A., additional, Eid, M., additional, Sayed, I., additional, Awadalla, H., additional, Schiano-Lomoriello, V., additional, Lo Iudice, F., additional, Ibrahimi, P., additional, Jashari, F., additional, Johansson, E., additional, Gronlund, C., additional, Bajraktari, G., additional, Wester, P., additional, Potluri, R., additional, Aziz, A., additional, Hooper, J., additional, Mummadi, S., additional, Uppal, H., additional, Asghar, O., additional, Chandran, S., additional, Surkova, E. A., additional, Tereshina, O. V., additional, Shchukin, U. V., additional, Rubanenko, A. O., additional, Medvedeva, E. A., additional, Krapf, L., additional, Nguyen, V., additional, Cimadevilla, C., additional, Himbert, D., additional, Brochet, E., additional, Iung, B., additional, Vahanian, A., additional, Messika-Zeitoun, D., additional, Van De Heyning, C. M., additional, Bruyere, P., additional, Davin, L., additional, De Maeyer, C., additional, Paelinck, B., additional, Vrints, C., additional, Bertrand, P., additional, Groenendaels, Y., additional, Vertessen, V., additional, Mullens, W., additional, Pettinari, M., additional, Gutermann, H., additional, Dion, R., additional, Verhaert, D., additional, Vandervoort, P., additional, Guven, S., additional, Sen, T., additional, Tufekcioglu, O., additional, Gucuk, E., additional, Uygur, B., additional, Kahraman, E., additional, Valuckiene, Z., additional, Jurkevicius, R., additional, Pranevicius, R., additional, Marcinkeviciene, J., additional, Zaliaduonyte-Peksiene, D., additional, Stoskute, N., additional, and Zaliunas, R., additional
Published: 2014
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16. Poster Session 3: Friday 9 December 2011, 08:30-12:30 * Location: Poster Area

Author: Kenny, C., primary, Adhya, S., additional, Dworakowski, R., additional, Brickham, B., additional, Maccarthy, P., additional, Monaghan, M., additional, Guzzo, A., additional, Innocenti, F., additional, Vicidomini, S., additional, Lazzeretti, D., additional, Squarciotta, S., additional, De Villa, E., additional, Donnini, C., additional, Bulletti, F., additional, Guerrini, E., additional, Pini, R., additional, Bendjelid, K., additional, Viale, J., additional, Duperret, S., additional, Piriou, V., additional, Jacques, D., additional, Shahgaldi, K., additional, Silva, C., additional, Pedro, F., additional, Deister, L., additional, Brodin, L.-A., additional, Sahlen, A., additional, Manouras, A., additional, Winter, R., additional, Berjeb, N., additional, Cimadevilla, C., additional, Dreyfus, J., additional, Cueff, C., additional, Malanca, M., additional, Chiampan, A., additional, Vahanian, A., additional, Messika-Zeitoun, D., additional, Muraru, D., additional, Peluso, D., additional, Dal Bianco, L., additional, Beraldo, M., additional, Solda', E., additional, Tuveri, M., additional, Cucchini, U., additional, Al Mamary, A., additional, Badano, L., additional, Iliceto, S., additional, Almuntaser, I., additional, King, G., additional, Norris, S., additional, Daly, C., additional, Ellis, E., additional, Murphy, R., additional, Erdei, T., additional, Denes, M., additional, Kardos, A., additional, Foldesi, C., additional, Temesvari, A., additional, Lengyel, M., additional, Bouzas Mosquera, A., additional, Broullon, F., additional, Alvarez-Garcia, N., additional, Peteiro, J., additional, Barge-Caballero, G., additional, Lopez-Perez, M., additional, Lopez-Sainz, A., additional, Castro-Beiras, A., additional, Luotolahti, M., additional, Luotolahti, H., additional, Kantola, I., additional, Viikari, J., additional, Andersen, M., additional, Ersboell, M., additional, Bro-Jeppesen, J., additional, Gustafsson, F., additional, Koeber, L., additional, Hassager, C., additional, Moller, J., additional, Coisne, D., additional, Diakov, C., additional, Vallet, F., additional, Lequeux, B., additional, Blouin, P., additional, Christiaens, L., additional, Esposito, R., additional, Santoro, A., additional, Schiano Lomoriello, V., additional, Raia, R., additional, Santoro, C., additional, De Simone, G., additional, Galderisi, M., additional, Abdula, G., additional, Kosmala, W., additional, Szczepanik-Osadnik, H., additional, Przewlocka-Kosmala, M., additional, Mysiak, A., additional, O' Moore-Sullivan, T., additional, Marwick, T., additional, Tan, Y. T., additional, Wenzelburger, F., additional, Leyva, F., additional, Sanderson, J., additional, Pichler, P., additional, Syeda, B., additional, Hoefer, P., additional, Zuckermann, A., additional, Binder, T., additional, Fijalkowski, M., additional, Koprowski, A., additional, Galaska, R., additional, Blaut, K., additional, Sworczak, K., additional, Rynkiewicz, A., additional, Lee, S., additional, Kim, W., additional, Jung, L., additional, Yun, H., additional, Song, M., additional, Ko, J., additional, Khalifa, E. A., additional, Szymanski, P., additional, Lipczynska, M., additional, Klisieiwcz, A., additional, Hoffman, P., additional, Jorge, C., additional, Silva Marques, J., additional, Robalo Martins, S., additional, Calisto, C., additional, Mieiro, M., additional, Vieira, S., additional, Correia, M., additional, Carvalho De Sousa, J., additional, Almeida, A., additional, Nunes Diogo, A., additional, Park, C., additional, March, K., additional, Tillin, T., additional, Mayet, J., additional, Chaturvedi, N., additional, Hughes, A., additional, Di Bello, V., additional, Giannini, C., additional, Delle Donne, M., additional, De Sanctis, F., additional, Spontoni, P., additional, Cucco, C., additional, Corciu, A., additional, Grigoratos, C., additional, Bogazzi, F., additional, Balbarini, A., additional, Enescu, O., additional, Suran, B., additional, Florescu, M., additional, Cinteza, M., additional, Vinereanu, D., additional, Higuchi, Y., additional, Iwakura, K., additional, Okamura, A., additional, Date, M., additional, Fujii, K., additional, Cortez-Dias, N., additional, Silva, D., additional, Carrilho-Ferreira, P., additional, Magalhaes, A., additional, Ribeiro, S., additional, Goncalves, S., additional, Fiuza, M., additional, Pinto, F., additional, Placido, R., additional, Bordalo, A., additional, Grzywocz, P., additional, Mizia-Stec, K., additional, Chudek, J., additional, Gasior, Z., additional, Maceira Gonzalez, A. M., additional, Cosin Sales, J., additional, Dalli, E., additional, Igual, B., additional, Diago, J., additional, Aguilar, J., additional, Ruvira, J., additional, Cimino, S., additional, Pedrizzetti, G., additional, Tonti, G., additional, Canali, E., additional, Petronilli, V., additional, Boccalini, F., additional, Mattatelli, A., additional, Hiramoto, Y., additional, Iacoboni, C., additional, Agati, L., additional, Trifunovic, D., additional, Ostojic, M., additional, Vujisic-Tesic, B., additional, Petrovic, M., additional, Nedeljkovic, I., additional, Banovic, M., additional, Boricic-Kostic, M., additional, Draganic, G., additional, Tesic, M., additional, Gavina, C., additional, Lopes, R., additional, Lourenco, A., additional, Almeida, J., additional, Rodrigues, J., additional, Pinho, P., additional, Zamorano, J., additional, Leite-Moreira, A., additional, Rocha-Goncalves, F., additional, Clavel, M.-A., additional, Capoulade, R., additional, Dumesnil, J., additional, Mathieu, P., additional, Despres, J.-P., additional, Pibarot, P., additional, Bull, S., additional, Pitcher, A., additional, Augustine, D., additional, D'arcy, J., additional, Karamitsos, T., additional, Rai, A., additional, Prendergast, B., additional, Becher, H., additional, Neubauer, S., additional, Myerson, S., additional, Magne, J., additional, Donal, E., additional, Davin, L., additional, O'connor, K., additional, Pirlet, C., additional, Rosca, M., additional, Szymanski, C., additional, Cosyns, B., additional, Pierard, L., additional, Lancellotti, P., additional, Calin, A., additional, Popescu, B., additional, Beladan, C., additional, Enache, R., additional, Lupascu, L., additional, Sandu, C., additional, Ginghina, C., additional, Kamperidis, V., additional, Hadjimiltiadis, S., additional, Sianos, G., additional, Anastasiadis, K., additional, Grosomanidis, V., additional, Efthimiadis, G., additional, Karvounis, H., additional, Parharidis, G., additional, Styliadis, I., additional, Gonzalez Canovas, C., additional, Munoz-Esparza, C., additional, Bonaque Gonzalez, J., additional, Fernandez, A., additional, Salar Alcaraz, M., additional, Saura Espin, D., additional, Pinar Bermudez, E., additional, Oliva-Sandoval, M., additional, De La Morena Valenzuela, G., additional, Valdes Chavarri, M., additional, Brochet, E., additional, Lepage, L., additional, Attias, D., additional, Detaint, D., additional, Himbert, D., additional, Iung, B., additional, Pirat, B., additional, Little, S., additional, Chang, S., additional, Tiller, L., additional, Kumar, R., additional, Zoghbi, W., additional, Lee, A. P.-W., additional, Hsiung, M., additional, Wan, S., additional, Wong, R., additional, Luo, F., additional, Fang, F., additional, Xie, J., additional, Underwood, M., additional, Sun, J., additional, Yu, C., additional, Jansen, R., additional, Tietge, W., additional, Sijbrandij, K., additional, Cramer, M., additional, De Heer, L., additional, Kluin, J., additional, Chamuleau, S. A. J., additional, Oliveras Vila, T., additional, Ferrer Sistach, E., additional, Delgado Ramis, L., additional, Lopez Ayerbe, J., additional, Vallejo Camazon, N., additional, Gual Capllonch, F., additional, Garcia Alonso, C., additional, Teis Soley, A., additional, Ruyra Baliarda, X., additional, Bayes Genis, A., additional, Negrea, S., additional, Alexandrescu, C., additional, Bourlon, F., additional, Civaia, F., additional, Dreyfus, G., additional, Paetzold, S., additional, Luha, O., additional, Hoedl, R., additional, Stoschitzky, G., additional, Pfeiffer, K., additional, Zweiker, D., additional, Pieske, B., additional, Maier, R., additional, Sevilla, T., additional, Revilla, A., additional, Lopez, J., additional, Vilacosta, I., additional, Arnold, R., additional, Gomez, I., additional, San Roman, J., additional, Nikcevic, G., additional, Djordjevic Dikic, A., additional, Djordjevic, S., additional, Raspopovic, S., additional, Jovanovic, V., additional, Kircanski, B., additional, Pavlovic, S., additional, Milasinovic, G., additional, Ruiz-Zamora, I., additional, Cabrera Bueno, F., additional, Molina, M., additional, Fernandez-Pastor, J., additional, Pena, J., additional, Linde, A., additional, Barrera, A., additional, Alzueta, J., additional, Bremont, C., additional, Bensaid, A., additional, Alonso, H., additional, Zaghden, O., additional, Nahum, J., additional, Dubois-Rande, J., additional, Gueret, P., additional, Lim, P., additional, Lee, S.-P., additional, Park, K., additional, Kim, H.-R., additional, Lee, J.-H., additional, Ahn, H.-S., additional, Kim, J.-H., additional, Kim, H.-K., additional, Kim, Y.-J., additional, Sohn, D.-W., additional, Niemann, M., additional, Herrmann, S., additional, Hu, K., additional, Liu, D., additional, Beer, M., additional, Ertl, G., additional, Wanner, C., additional, Takenaka, T., additional, Tei, C., additional, Weidemann, F., additional, Madeira, H., additional, Mendes Pedro, M., additional, Brito, D., additional, Ippolito, R., additional, De Palma, D., additional, Gati, S., additional, Oxborough, D., additional, Reed, M., additional, Zaidi, A., additional, Ghani, S., additional, Sheikh, N., additional, Papadakis, M., additional, Sharma, S., additional, Chow, V., additional, Ng, A., additional, Pasqualon, T., additional, Zhao, W., additional, Hanzek, D., additional, Chung, T., additional, Yeoh, T., additional, Kritharides, L., additional, Magda, L., additional, Mihalcea, D., additional, Jinga, D., additional, Mincu, R., additional, Ferrazzi, E., additional, Segato, G., additional, Folino, F., additional, Famoso, G., additional, Senzolo, M., additional, Bellu, R., additional, Corbetti, F., additional, Tona, F., additional, Azevedo, O., additional, Quelhas, I., additional, Guardado, J., additional, Fernandes, M., additional, Pereira, V., additional, Medeiros, R., additional, Sousa, P., additional, Santos, W., additional, Pereira, S., additional, Marques, N., additional, Mimoso, J., additional, Marques, V., additional, Jesus, I., additional, Rustad, L., additional, Nytroen, K., additional, Gullestad, L., additional, Amundsen, B., additional, Aakhus, S., additional, Linhartova, K., additional, Sterbakova, G., additional, Necas, J., additional, Kovalova, S., additional, Cerbak, R., additional, Nelassov, N., additional, Korotkijan, N., additional, Shishkina, A., additional, Gagieva, B., additional, Nagaplev, M., additional, Eroshenko, O., additional, Morgunov, M., additional, Parmon, S., additional, Velthuis, S., additional, Van Gent, M., additional, Post, M., additional, Westermann, C., additional, Mager, J., additional, Snijder, R., additional, Koyalakonda, S. P., additional, Anderson, M., additional, Burgess, M., additional, Bergenzaun, L., additional, Chew, M., additional, Ohlin, H., additional, Gjerdalen, G. F., additional, Hisdal, J., additional, Solberg, E., additional, Andersen, T., additional, Radunovic, Z., additional, Steine, K., additional, Rutz, T., additional, Kuehn, A., additional, Petzuch, K., additional, Pekala, M., additional, Elmenhorst, J., additional, Fratz, S., additional, Mueller, J., additional, Hager, A., additional, Hess, J., additional, Vogt, M., additional, Van Der Linde, D., additional, Van De Laar, I., additional, Wessels, M., additional, Bekkers, J., additional, Moelker, A., additional, Tanghe, H., additional, Van Kooten, F., additional, Oldenburg, R., additional, Bertoli-Avella, A., additional, Roos-Hesselink, J., additional, Cresti, A., additional, Fontani, L., additional, Calabria, P., additional, Capati, E., additional, Severi, S., additional, Lynch, M., additional, Saraf, S., additional, Sandler, B., additional, Yoon, S., additional, Kim, S., additional, Ko, C., additional, Ryu, S., additional, Byun, Y., additional, Seo, H., additional, Ciampi, Q., additional, Rigo, F., additional, Pratali, L., additional, Gherardi, S., additional, Villari, B., additional, Picano, E., additional, Sicari, R., additional, Celutkiene, J., additional, Zakarkaite, D., additional, Skorniakov, V., additional, Zvironaite, V., additional, Grabauskiene, V., additional, Sinicyna, J., additional, Gruodyte, G., additional, Janonyte, K., additional, Laucevicius, A., additional, O'driscoll, J., additional, Schmid, K., additional, Marciniak, A., additional, Saha, A., additional, Gupta, S., additional, Smith, R., additional, Sharma, R., additional, Alvarez Garcia, N., additional, Prada, O., additional, Rodriguez Vilela, A., additional, Barge Caballero, G., additional, Lopez Perez, M., additional, Lopez Sainz, A., additional, Castro Beiras, A., additional, Kochanowski, J., additional, Scislo, P., additional, Piatkowski, R., additional, Grabowski, M., additional, Marchel, M., additional, Roik, M., additional, Kosior, D., additional, Opolski, G., additional, Van De Heyning, C. M., additional, Mahjoub, H., additional, Clausen, H., additional, Basaggianis, C., additional, Newton, J., additional, Del Pasqua, A., additional, Carotti, A., additional, Di Carlo, D., additional, Cetrano, E., additional, Toscano, A., additional, Iacobelli, R., additional, Esposito, C., additional, Chinali, M., additional, Pongiglione, G., additional, Rinelli, G., additional, Larsson, M., additional, Bjallmark, A., additional, Caidahl, K., additional, Brodin, L., additional, Gao, H., additional, Lugiez, M., additional, Guivier, C., additional, Rieu, R., additional, D'hooge, J., additional, Hang, G., additional, Guerin, C., additional, Menard, M., additional, Voigt, J.-U., additional, Dungu, J., additional, Campos, G., additional, Jaffarulla, R., additional, Gomes-Pereira, S., additional, Sutaria, N., additional, Baker, C., additional, Nihoyannopoulos, P., additional, Bellamy, M., additional, Harries, D., additional, Walker, N., additional, Pearson, P., additional, Reiken, J., additional, Batteson, J., additional, Kamdar, R., additional, Murgatroyd, F., additional, D'andrea, A., additional, Riegler, L., additional, Scarafile, R., additional, Pezzullo, E., additional, Salerno, G., additional, Bossone, E., additional, Limongelli, G., additional, Russo, M., additional, Pacileo, G., additional, Calabro', R., additional, Kang, Y., additional, Cui, J., additional, Chen, H., additional, Pan, C., additional, Shu, X., additional, Kiotsekoglou, A., additional, Saha, S., additional, Toole, R., additional, Govind, S., additional, Gopal, A., additional, Crispi, F., additional, Bijnens, B., additional, Sepulveda-Swatson, E., additional, Rojas-Benavente, J., additional, Dominguez, J., additional, Illa, M., additional, Eixarch, E., additional, Sitges, M., additional, Gratacos, E., additional, Prinz, C., additional, Faludi, R., additional, Walker, A., additional, Amzulescu, M., additional, Uejima, T., additional, Fraser, A., additional, Voigt, J., additional, Esmaeilzadeh, M., additional, Maleki, M., additional, Amin, A., additional, Vakilian, F., additional, Noohi, F., additional, Ojaghi Haghighi, Z., additional, Nakhostin Davari, P., additional, Bakhshandeh Abkenar, H., additional, Rimbas, R., additional, Dulgheru, R., additional, Margulescu, A., additional, D' Asaro, M., additional, Mizzon, C., additional, Parisi, F., additional, Jung, B.-C., additional, Lee, B.-Y., additional, Kang, H.-J., additional, Kim, M., additional, Kim, Y., additional, Cho, D., additional, Park, S., additional, Hong, S., additional, Lim, D., additional, Shim, W., additional, Bellsham-Revell, H., additional, Tibby, S., additional, Bell, A. J., additional, Miller, O. I., additional, Greil, G., additional, Simpson, J. M., additional, Providencia, R. A., additional, Trigo, J., additional, Botelho, A., additional, Gomes, P., additional, Seca, L., additional, Barra, S., additional, Faustino, A., additional, Costa, G., additional, Quintal, N., additional, Leitao-Marques, A., additional, Nestaas, E., additional, Stoylen, A., additional, Fugelseth, D., additional, Mornos, C., additional, Ionac, A., additional, Petrescu, L., additional, Cozma, D., additional, Dragulescu, D., additional, Mornos, A., additional, Pescariu, S., additional, Fontana, A., additional, Abbate, M., additional, Cazzaniga, M., additional, Giannattasio, C., additional, Trocino, G., additional, Laser, K., additional, Faber, L., additional, Fischer, M., additional, Koerperich, H., additional, Kececioglu, D., additional, Elnoamany, M. F., additional, Dawood, A., additional, Elhabashy, M., additional, Khalil, Y., additional, Piriou, N., additional, Warin-Fresse, K., additional, Caza, M., additional, Fau, G., additional, Crochet, D., additional, Xhabija, N., additional, Allajbeu, I., additional, Petrela, E., additional, Heba, M., additional, Barreiro Perez, M., additional, Martin Fernandez, M., additional, Renilla Gonzalez, A., additional, Florez Munoz, J., additional, Fernandez Cimadevilla, O., additional, Alvarez Pichel, I., additional, Velasco Alonso, E., additional, Leon Duran, D., additional, Benito Martin, E., additional, Secades Gonzalez, S., additional, Gargani, L., additional, Pang, P., additional, Davis, E., additional, Schumacher, A., additional, Silva Ferreira, A., additional, Bettencourt, N., additional, Matos, P., additional, Oliveira, L., additional, Cosin-Sales, J., additional, Lopez Lereu, M., additional, Monmeneu, J., additional, Estornell, J., additional, Tsverava, M., additional, Tsverava, D., additional, Varela, A., additional, Salagianni, M., additional, Galani, I., additional, Andreakos, E., additional, Davos, C., additional, Ikonomidis, I., additional, Lekakis, J., additional, Tritakis, V., additional, Kadoglou, N., additional, Papadakis, J., additional, Trivilou, P., additional, Tzortzis, S., additional, Koukoulis, C., additional, Paraskevaidis, I., additional, Anastasiou-Nana, M., additional, Kim, G., additional, Youn, H., additional, Ibrahimi, P., additional, Bajraktari, G., additional, Jashari, F., additional, Ahmeti, A., additional, Poniku, A., additional, Haliti, E., additional, Henein, M., additional, Pezo Nikolic, B., additional, Jurin, H., additional, Lovric, D., additional, Baricevic, Z., additional, Ivanac Vranesic, I., additional, Lovric Bencic, M., additional, Ernst, A., additional, and Separovic Hanzevacki, J., additional
Published: 2011
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17. Club 35 Poster session 2: Thursday 4 December 2014, 08:30-18:00 * Location: Poster area

Author: Santos, M, Rivero, J, Mccullough, SD, Opotowsky, AR, Waxman, AB, Systrom, D, Shah, AM, Olsen, F J, Jorgensen, PG, Mogelvang, R, Jensen, JS, Fritz-Hansen, T, Bech, J, Sivertsen, J, Biering-Sorensen, T, Santoro, C, Esposito, R, Schiano Lomoriello, V, Raia, R, De Palma, D, Ippolito, R, Ierano, P, Arpino, G, De Simone, G, Galderisi, M, Cameli, M, Lisi, M, Di Tommaso, C, Solari, M, Focardi, M, Maccherini, M, Henein, M, Galderisi, M, Mondillo, S, Simova, I, Katova, T, Galderisi, M, Pauncheva, B, Vrettos, A, Dawson, D, Grigoratos, C, Papapolychroniou, C, Nihoyannopoulos, P, Danylenko, O, Kovalenko, V, Nesukay, E, Polenova, N, Titov, I, Voilliot, D, Huttin, OH, Vaugrenard, TV, Venner, CV, Sadoul, NS, Aliot, EA, Juilliere, YJ, Selton-Suty, CSS, Hamdi, I, Mahfoudhi, H, Ben Mansour, N, Dahmani, R, Lahidheb, D, Fehri, W, Haouala, H, Erken Pamukcu, H, Gerede, DM, Sorgun, M, Akbostanci, C, Turhan, S, Erol, û, Voilliot, D, Magne, JM, Dulgheru, RD, Kou, SK, Henri, CH, Caballero, LC, De Sousa, CDS, Sprynger, MS, Pierard, LP, Lancellotti, PL, Panelo, M L, Rodriguez-Fernandez, A, Escriba-Bori, S, Krol, W, Konopka, M, Burkhard, K, Jedrzejewska, I, Pokrywka, A, Klusiewicz, A, Chwalbinska, J, Dluzniewski, M, Braksator, W, Elmissiri, AM, Eid, M, Sayed, I, Awadalla, H, Schiano-Lomoriello, V, Esposito, R, Santoro, C, Lo Iudice, F, De Simone, G, Galderisi, M, Ibrahimi, P, Jashari, F, Johansson, E, Gronlund, C, Bajraktari, G, Wester, P, Henein, MY, Potluri, R, Aziz, A, Hooper, J, Mummadi, SM, Uppal, H, Asghar, O, Chandran, S, Surkova, E A, Tereshina, O V, Shchukin, U V, Rubanenko, A O, Medvedeva, E A, Hamdi, I, Mahfoudhi, H, Ben Mansour, N, Dahmani, R, Lahidheb, D, Fehri, W, Haouala, H, Krapf, L, Nguyen, V, Cimadevilla, C, Himbert, D, Brochet, E, Iung, B, Vahanian, A, Messika-Zeitoun, D, Danylenko, O, Kovalenko, V, Nesukay, E, Titov, I, Polenova, N, Van De Heyning, C M, Magne, J, Pierard, LA, Bruyere, PJ, Davin, L, De Maeyer, C, Paelinck, BP, Vrints, CJ, Lancellotti, P, Bertrand, PB, Groenendaels, Y, Vertessen, VJ, Mullens, W, Pettinari, M, Gutermann, H, Dion, RA, Verhaert, D, Vandervoort, PM, Guven, S, Sen, T, Tufekcioglu, O, Gucuk, E, Uygur, B, Kahraman, E, Valuckiene, Z, Jurkevicius, R, Pranevicius, R, Marcinkeviciene, J, Zaliaduonyte-Peksiene, D, Stoskute, N, and Zaliunas, R
Abstract: Introduction: Among patients with unexplained dyspnea, left ventricular (LV) filling pressures (LVFP) is commonly estimated non-invasively by the E/e' ratio using Doppler echocardiography. However the accuracy of E/e' is controversial. We evaluated the correlation of E/e' ratio with invasively measured LVFP and of change in E/e' (ΔE/e') with change in LVFP. Methods: Supine and upright transthoracic echocardiography was performed in patients with unexplained dyspnea undergoing right heart catheterization. Patients with significant valvular disease and reduced LV ejection fraction (LVEF < 50%) were excluded. Pulmonary artery wedge pressure (PAWP) was used as the invasive indicator of LVFP. The mean of septal and lateral e' velocities was used for the calculation of E/e' ratio. Results: We studied 98 subjects with a mean age of 52 ± 20 years (69% of female gender). The supine E/e' and PAWP were 9.2 ± 3.2 and 12.1 ± 4.9 mmHg (range: 4-27 mmHg) respectively and were modestly correlated (r=0.38; p<0.001). With position change (supine to upright), ΔPAWP was -5.1 ± 4.3 mmHg and ΔE/e' was 0.17 ± 2.6, with no significant association between these two measures (r=0.003; p=0.98). Both E-wave (80 ± 22 to 65 ± 22 cm/s) and mean average e' (10.2 ± 3.6 to 7.3 ± 2.0 cm/s) decreased with the upright position. The ΔPAWP was correlated with ΔE-wave velocity (r=0.33; p=0.01), but not with Δe' (r=0.14; p=0.26). Conclusions: In patients with unexplained dyspnea and a preserved LVEF, E/e' is modestly, though significantly, correlated with PAWP. ΔE/e' is not correlated with ΔPAWP, partially related to the preload sensitivity of e'. Figure Figure 1 - Supine and delta E/e' plotted
Published: 2014
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18. Poster session 3: Thursday 4 December 2014, 14:00-18:00 * Location: Poster area

Author: Shahgaldi, K, Hegner, T, Da Silva, C, Fukuyama, A, Takeuchi, M, Uema, A, Kado, Y, Nagata, Y, Hayashi, A, Otani, K, Fukuda, S, Yoshitani, H, Otsuji, Y, Morhy, S, Lianza, AC, Afonso, TR, Oliveira, WA, Tavares, GP, Rodrigues, AC, Vieira, MC, Warth, AN, Deutsch, AD, Fischer, CH, Tezynska-Oniszk, I, Turska-Kmiec, A, Kawalec, W, Dangel, J, Maruszewski, B, Bokiniec, R, Burczynski, P, Borszewska-Kornacka, K, Ziolkowska, L, Zuk, M, Mazowsza, eSUM Dzieciaki, Troshina, A, Dzhalilova, DA, Poteshkina, NG, Hamitov, FF, Warita, S, Kawasaki, M, Tanaka, R, Yagasaki, H, Minatoguchi, S, Wanatabe, T, Ono, K, Noda, T, Wanatabe, S, Minatoguchi, S, Angelis, A, Ageli, K, Vlachopoulos, C, Felekos, I, Ioakimidis, N, Aznaouridis, K, Vaina, S, Abdelrasoul, M, Tsiamis, E, Stefanadis, C, Cameli, M, Sparla, S, D'ascenzi, F, Fineschi, M, Favilli, R, Pierli, C, Henein, M, Mondillo, S, Lindqvist, P, Tossavainen, E, Gonzalez, M, Soderberg, S, Henein, M, Holmgren, A, Strachinaru, M, Catez, E, Jousten, I, Pavel, O, Janssen, C, Morissens, M, Chatzistamatiou, E, Moustakas, G, Memo, G, Konstantinidis, D, Mpampatzeva Vagena, I, Manakos, K, Traxanas, K, Vergi, N, Feretou, A, Kallikazaros, I, Tsai, W-C, Sun, Y-T, Lee, W-H, Yang, L-T, Liu, Y-W, Lee, C-H, Li, W-T, Mizariene, V, Bieseviciene, M, Karaliute, R, Verseckaite, R, Vaskelyte, J, Lesauskaite, V, Chatzistamatiou, E, Mpampatseva Vagena, I, Manakos, K, Moustakas, G, Konstantinidis, D, Memo, G, Mitsakis, O, Kasakogias, A, Syros, P, Kallikazaros, I, Hristova, K, Cornelissen, G, Singh, RB, Shiue, I, Coisne, D, Madjalian, A-M, Tchepkou, C, Raud Raynier, P, Degand, B, Christiaens, L, Baldenhofer, G, Spethmann, S, Dreger, H, Sanad, W, Baumann, G, Stangl, K, Stangl, V, Knebel, F, Azzaz, S, Kacem, S, Ouali, S, Risos, L, Dedobbeleer, C, Unger, P, Sinem Cakal, SC, Elif Eroglu, EE, Baydar, O, Beytullah Cakal, BC, Mehmet Vefik Yazicioglu, MVY, Mustafa Bulut, MB, Cihan Dundar, CD, Kursat Tigen, KT, Birol Ozkan, BO, Ali Metin Esen, AME, Tournoux, F, Chequer, R, Sroussi, M, Hyafil, F, Rouzet, F, Leguludec, D, Baum, P, Stoebe, S, Pfeiffer, D, Hagendorff, A, Fang, F, Lau, M, Zhang, Q, Luo, XX, Wang, XY, Chen, L, Yu, CM, -CRT, Predict, Zaborska, B, Smarz, K, Makowska, E, Kulakowski, P, Budaj, A, Bengrid, T M, Zhao, Y, Henein, M Y, Caminiti, G, D'antoni, V, Cardaci, V, Conti, V, Volterrani, M, Warita, S, Kawasaki, M, Yagasaki, H, Minatoguchi, S, Nagaya, M, Ono, K, Noda, T, Watanabe, S, Houle, H, Minatoguchi, S, Gillebert, T C, Chirinos, J A, Claessens, T C, Raja, M W, De Buyzere, M L, Segers, P, Rietzschel, E R, Investigators, The Asklepios, Kim, KH, Cha, JJ, Chung, HM, Kim, JY, Yoon, YW, Lee, BK, Hong, BK, Rim, SJ, Kwon, HM, Choi, EY, Pyankov, V, Aljaroudi, W, Matta, S, Al-Shaar, L, Habib, R, Gharzuddin, W, Arnaout, S, Skouri, H, Jaber, W, Abchee, A, Bouzas Mosquera, A, Peteiro, J, Broullon, FJ, Constanso Conde, IP, Bescos Galego, H, Martinez Ruiz, D, Yanez Wonenburger, JC, Vazquez Rodriguez, JM, Alvarez Garcia, N, Castro Beiras, A, Gunyeli, E, Oliveira Da Silva, C, Shahgaldi, K, Manouras, A, Winter, R, Meimoun, P, Abouth, S, Martis, S, Boulanger, J, Elmkies, F, Zemir, H, Detienne, JP, Luycx-Bore, A, Clerc, J, Rodriguez Palomares, J F, Gutierrez, LG, Maldonado, GM, Garcia, GG, Galuppo, VG, Gruosso, DG, Teixido, GT, Gonzalez Alujas, MTGA, Evangelista, AE, Garcia Dorado, DGD, Rechcinski, T, Wierzbowska-Drabik, K, Wejner-Mik, P, Szymanska, B, Jerczynska, H, Lipiec, P, Kasprzak, JD, El-Touny, K, El-Fawal, S, Loutfi, M, El-Sharkawy, E, Ashour, S, Boniotti, C, Carminati, MC, Fusini, L, Andreini, D, Pontone, G, Pepi, M, Caiani, EG, Oryshchyn, N, Kramer, B, Hermann, S, Liu, D, Hu, K, Ertl, G, Weidemann, F, Ancona, F, Miyazaki, S, Slavich, M, Figini, F, Latib, A, Chieffo, A, Montorfano, M, Alfieri, O, Colombo, A, Agricola, E, Nogueira, MA, Branco, LM, Rosa, SA, Portugal, G, Galrinho, A, Abreu, J, Cacela, D, Patricio, L, Fragata, J, Cruz Ferreira, R, Igual Munoz, B, Erdociain Perales, MEP, Maceira Gonzalez, AMG, Estornell Erill Jordi, JEE, Donate Bertolin, LDB, Vazquez Sanchez Alejandro, AVS, Miro Palau Vicente, VMP, Cervera Zamora, ACZ, Piquer Gil, MPG, Montero Argudo, AMA, Girgis, H Y A, Illatopa, V, Cordova, F, Espinoza, D, Ortega, J, Khan, US, Islam, AKMM, Majumder, AAS, Girgis, H Y A, Bayat, F, Naghshbandi, E, Naghshbandi, E, Samiei, N, Samiei, N, Malev, E, Omelchenko, M, Vasina, L, Zemtsovsky, E, Piatkowski, R, Kochanowski, J, Budnik, M, Scislo, P, Opolski, G, Kochanowski, J, Piatkowski, R, Scislo, P, Budnik, M, Marchel, M, Opolski, G, Abid, L, Ben Kahla, S, Abid, D, Charfeddine, S, Maaloul, I, Ben Jmaa, M, Kammoun, S, Hashimoto, G, Suzuki, M, Yoshikawa, H, Otsuka, T, Isekame, Y, Yamashita, H, Kawase, I, Ozaki, S, Nakamura, M, Sugi, K, Benvenuto, E, Leggio, S, Buccheri, S, Bonura, S, Deste, W, Tamburino, C, Monte, I P, Gripari, P, Fusini, L, Muratori, M, Tamborini, G, Ghulam Ali, S, Bottari, V, Cefalu', C, Bartorelli, A, Agrifoglio, M, Pepi, M, Zambon, E, Iorio, A, Di Nora, C, Abate, E, Lo Giudice, F, Di Lenarda, A, Agostoni, P, Sinagra, G, Timoteo, A T, Galrinho, A, Moura Branco, L, Rio, P, Aguiar Rosa, S, Oliveira, M, Silva Cunha, P, Leal, A, Cruz Ferreira, R, Zemanek, D, Tomasov, P, Belehrad, M, Kostalova, J, Kara, T, Veselka, J, Hassanein, M, El Tahan, S, El Sharkawy, E, Shehata, H, Yoon, YE, Choi, HM, Seo, HY, Lee, SP, Kim, HK, Youn, TJ, Kim, YJ, Sohn, DW, Choi, GY, Mielczarek, M, Huttin, O, Voilliot, D, Sellal, JM, Manenti, V, Carillo, S, Olivier, A, Venner, C, Juilliere, Y, Selton-Suty, C, Butz, T, Faber, L, Brand, M, Piper, C, Wiemer, M, Noelke, J, Sasko, B, Langer, C, Horstkotte, D, Trappe, HJ, Maysou, LA, Tessonnier, L, Jacquier, A, Serratrice, J, Copel, C, Stoppa, AM, Seguier, J, Saby, L, Verschueren, A, Habib, G, Petroni, R, Bencivenga, S, Di Mauro, M, Acitelli, A, Cicconetti, M, Romano, S, Petroni, A, Penco, M, Maceira Gonzalez, A M, Cosin-Sales, J, Igual, B, Sancho-Tello, R, Ruvira, J, Mayans, J, Choi, JH, Kim, SWK, Almeida, A, Azevedo, O, Amado, J, Picarra, B, Lima, R, Cruz, I, Pereira, V, Marques, N, Biering-Sorensen, T, Mogelvang, R, Schnohr, P, Jensen, JS, Chatzistamatiou, E, Konstantinidis, D, Manakos, K, Mpampatseva Vagena, I, Moustakas, G, Memo, G, Mitsakis, O, Kasakogias, A, Syros, P, Kallikazaros, I, Cho, EJ, Kim, JJ, Hwang, BH, Kim, DB, Jang, SW, Jeon, HK, Cho, JS, Chatzistamatiou, E, Konstantinidis, D, Memo, G, Mpapatzeva Vagena, I, Moustakas, G, Manakos, K, Traxanas, K, Vergi, N, Feretou, A, Kallikazaros, I, Jedrzejewska, I, Konopka, M, Krol, W, Swiatowiec, A, Dluzniewski, M, Braksator, W, Sefri Noventi, S, Sugiri, S, Uddin, I, Herminingsih, S, Arif Nugroho, M, Boedijitno, S, Caro Codon, J, Blazquez Bermejo, Z, Valbuena Lopez, S C, Lopez Fernandez, T, Rodriguez Fraga, O, Torrente Regidor, M, Pena Conde, L, Moreno Yanguela, M, Buno Soto, A, Lopez-Sendon, J L, Stevanovic, A, Dekleva, M, Kim, MN, Kim, SA, Kim, YH, Shim, JM, Park, SM, Park, SW, Kim, YH, Shim, WJ, Kozakova, M, Muscelli, E, Morizzo, C, Casolaro, A, Paterni, M, Palombo, C, Bayat, F, Nazmdeh, M, Naghshbandi, E, Nateghi, S, Tomaszewski, A, Kutarski, A, Brzozowski, W, Tomaszewski, M, Nakano, E, Harada, T, Takagi, Y, Yamada, M, Takano, M, Furukawa, T, Akashi, Y, Lindqvist, G, Henein, MY, Backman, C, Gustafsson, S, Morner, S, Marinov, R, Hristova, K, Geirgiev, S, Pechilkov, D, Kaneva, A, Katova, TZ, Pilosoff, V, Pena Pena, ML, Mesa Rubio, D, Ruiz Ortin, M, Delgado Ortega, M, Romo Penas, E, Pardo Gonzalez, L, Rodriguez Diego, S, Hidalgo Lesmes, F, Pan Alvarez-Ossorio, M, Suarez De Lezo Cruz-Conde, J, Gospodinova, M, Sarafov, S, Guergelcheva, V, Vladimirova, L, Tournev, I, Denchev, S, Mozenska, O, Segiet, A, Rabczenko, D, Kosior, DA, Gao, SA, Eliasson, M, Polte, CL, Lagerstrand, K, Bech-Hanssen, O, Morosin, M, Piazza, R, Leonelli, V, Leiballi, E, Pecoraro, R, Cinello, M, Dell' Angela, L, Cassin, M, Sinagra, G, Nicolosi, GL, Savu, O, Carstea, N, Stoica, E, Macarie, C, Moldovan, H, Iliescu, V, Chioncel, O, Moral, S, Gruosso, D, Galuppo, V, Teixido, G, Rodriguez-Palomares, JF, Gutierrez, L, Evangelista, A, Jansen Klomp, W W, Peelen, LM, Spanjersberg, AJ, Brandon Bravo Bruinsma, GJ, Van 'T Hof, AWJ, Laveau, F, Hammoudi, N, Helft, G, Barthelemy, O, Michel, PL, Petroni, T, Djebbar, M, Boubrit, L, Le Feuvre, C, Isnard, R, Cho, EJ, Park, S-J, Kim, CH, Song, JE, Kim, SH, Chang, S-A, Lee, S-C, Park, SW, Bandera, F, Generati, G, Pellegrino, M, Alfonzetti, E, Labate, V, Villani, S, Gaeta, M, Guazzi, M, Gabriels, C, Lancellotti, P, Van De Bruaene, A, Voilliot, D, De Meester, P, Buys, R, Delcroix, M, Budts, W, Cruz, I, Stuart, B, Caldeira, D, Morgado, G, Almeida, AR, Lopes, LR, Fazendas, P, Joao, I, Cotrim, C, Pereira, H, Weissler Snir, A, Greenberg, G, Shapira, Y, Weisenberg, D, Monakier, D, Nevzorov, R, Sagie, A, Vaturi, M, Bando, M, Yamada, H, Saijo, Y, Takagawa, Y, Sawada, N, Hotchi, J, Hayashi, S, Hirata, Y, Nishio, S, Sata, M, Jackson, TA, Sammut, E, Siarkos, M, Lee, L, Carr-White, G, Rajani, R, Kapetanakis, S, Ciobotaru, V, Yagasaki, H, Kawasaki, M, Tanaka, R, Minatoguchi, S, Sato, N, Amano, K, Warita, S, Ono, K, Noda, T, Minatoguchi, S, Breithardt, O-A, Razavi, H, Nabutovsky, Y, Ryu, K, Gaspar, T, Kosiuk, J, John, S, Prinzen, F, Hindricks, G, Piorkowski, C, Nemchyna, O, Tovstukha, V, Chikovani, A, Golikova, I, Lutai, M, Nemes, A, Kalapos, A, Domsik, P, Lengyel, C, Orosz, A, Forster, T, Nordenfur, T, Babic, A, Giesecke, A, Bulatovic, I, Ripsweden, J, Samset, E, Winter, R, Larsson, M, Blazquez Bermejo, Z, Lopez Fernandez, T, Caro Codon, J, Valbuena, SC, Caro Codon, J, Mori Junco, R, Moreno Yanguela, M, Lopez-Sendon, JL, MEdicamentos, Grupo de Estudio de CArdiotoxicidad por, Pinto-Teixeira, P, Branco, L, Galrinho, A, Oliveira, M, Cunha, P, Silva, T, Rio, P, Feliciano, J, Nogueira-Silva, M, Ferreira, R, Shkolnik, E, Vasyuk, Y, Nesvetov, V, Shkolnik, L, Varlan, G, Bajraktari, G, Ronn, F, Ibrahimi, P, Jashari, F, Jensen, SM, Henein, MY, Kang, M-K, Mun, H-S, Choi, S, Cho, J-R, Han, SW, Lee, N, Cho, I J, Heo, R, Chang, HJ, Shin, S, Shim, CY, Hong, GR, and Chung, N
Abstract: Objective: We aimed to investigate the reproducibility of vena contracta (VC) in mitral regurgitation (MR) of different etiology between an inexperienced and an experienced echocardiographer. Background: MR is the second most common valvular heart disease in Europe that requires surgery. Echocardiography is the principal modality of investigation when MR is suspected. In European and American guidelines VC is described as one of the most feasible echocardiographic measurements in the assessment of MR. There is a lack of publications regarding intra-observer variability and studies comparing inexperienced and experienced echocardiographers for the assessment of VC. Method/Material: VC of 55 recorded 2D echocardiograms with known MR of different degree and etiology were analyzed from parasternal long axis view, 4- and 3 chamber view. The mean value of the different plane measurements of each exam was used for statistical analysis. Analyses were made by an inexperienced (A) fellow echocardiographer (<100 studies) and a level 3 experienced (B) echocardiographer. Measurements of VC by the 2 echocardiographers were performed blinded to clinical data. Measurements were performed with at least 2 weeks apart, blinded to the first measurement. Results: Three exams were excluded (feasibility 95%) from statistical analysis because adequate color Doppler images from all tree planes was not available. The inter class correlation (ICC) between the first and second analysis was (r=0.75; 95% CI -1.1 to 1.7mm) for A and (r=0.94; 95% CI -0.76 to 0.84mm) for B. There was good ICC between the 2 echocardiographers (r=0.78; 95% CI -1.5 to 1.3mm). The intra observer variability was 11.1% for A and 6.1% for B. The inter observer variability was 11.7% (p>0.05 for all). Conclusion: Measurement of vena contracta in mitral regurgitation is a feasible semi-quantitative parameter. Good correlation and narrow limits of agreement between a novice and an experienced echocardiographer was demonstrated in our study.
Published: 2014
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19. Club 35 Poster session 1: Wednesday 3 December 2014, 09:00-16:00 * Location: Poster area

Author: Krestjyaninov, MV, Gimaev, RH, Razin, VA, Halaph, H, Shameeva, OV, Galli, E, Oger, E, Levery, M, Mabo, P, Donal, E, Rodriguez Munoz, D, Carbonell Sanroman, A, Moya Mur, JL, Lazaro Rivera, C, Fernandez Santos, S, Rincon Diaz, LM, Casas Rojo, E, Jimenez Nacher, JJ, Fernandez-Golfin, C, Zamorano Gomez, JL, Shamsheva, D, Zaletova, T, Parkhomenko, O, Bogdanov, A, Simova, I, Katova, T, Galderisi, M, Pauncheva, B, Ozawa, K, Funabashi, N, Takaoka, H, Kobayashi, Y, Titov, I, Kovalenko, V, Nesukay, E, Danylenko, O, Polenova, N, Moatemri, F, Messaoudi, Y, Mahdhaoui, A, Bouraoui, H, Hajri, S, Jeridi, G, Danylenko, O, Kovalenko, V, Nesukay, E, Polenova, N, Titov, I, Souza, C, Nascimento, CAS, Cordovil, IP, Belem, LJH, Horcades, RF, Sahate, AS, Pereira, SB, Benchimol-Barbosa, PR, Barros, CN, Weitzel, LH, Altin, C, Sade, LE, Gezmis, E, Ozen, N, Muderrisoglu, H, Voilliot, D, Magne, JM, Dulgheru, RD, Kou, SK, Henri, CH, Caballero, LC, De Sousa, CDS, Sprynger, MS, Pierard, LP, Lancellotti, PL, Miglioranza, MH, Mihaila, S, Muraru, D, Cucchini, U, Cecchetto, A, Cavalli, G, Romeo, G, Iliceto, S, Badano, LP, Brecht, A, Wageloehner, T, Oertelt-Prigione, S, Seeland, U, Ruecke, M, Baumann, G, Regitz-Zagrosek, V, Stangl, V, Knebel, F, Investigators, BEFRI, Khanna, R, Raghuwanshi, A, Kapoor, A, Tewari, S, Garg, N, Kumar, S, Goel, PK, Altin, C, Sade, LE, Gezmis, E, Ozen, N, Duzceker, O, Muderrisoglu, H, Petre, I, Tautu, OF, Onciul, S, Iancovici, S, Zamfir, D, Onut, R, Dorobantu, M, Jashari, F, Ibrahimi, P, Johansson, E, Gronlund, C, Bajraktari, G, Wester, P, Henein, MY, Torbas, O, Sirenko, YU, Radchenko, G, Page, M, Gerber, BL, Pasquet, A, Pouleur, AC, Vancreynest, D, Vanoverschelde, JL, Wieczorek, J, Wieczorek, P, Mizia, M, Gieszczyk-Strozik, K, Sikora-Puz, A, Lasota, B, Mizia-Stec, K, Coisne, A, Levy, F, Malaquin, D, Richardson, M, Quere, JP, Montaigne, D, Tribouilloy, C, Teixeira, R, Monteiro, R, Barbosa, A, Batista, R, Ribeiro, M, Cardim, N, Goncalves, L, Miskowiec, D, Wierzbowska-Drabik, K, Wejner-Mik, P, Michalski, B, Wdowiak-Okrojek, K, Szymczyk, E, Kasprzak, JD, Lipiec, P, Grossi, F, Oddo, A, Pieri, F, Cordisco, A, Zucchini, M, Mori, F, and Gensini, GF
Abstract: Left ventricle hypertrophy (LVH) is strongly associated with stroke and myocardial infarction in hypertensive patients. Hypertensive heart characterized by cardiomyocytes hypertrophy, fibroblasts proliferation, enlargement of interstitial collagen volume and their ratio disorders which result in dangerous complications. Renin-angiotensin-aldosterone system (RAAS) and insulin-like growth factor 1 (IGF-1) play significant role in development of myocardial fibrosis and LV remodelling in hypertensive patients. The purpose of the study is to evaluate relations between activity of RAAS and interstitial fibrosis markers and left ventricle geometry models in hypertensive patients. Were examined 286 patients (both men and women) with Hypertension 2-3 grade and stable ischemic heart disease 2-3 functional class complicated by chronic heart failure I-III NYHA functional class. The mean age of patients 53 (3.7) years. Patients with arrhythmias, diabetes mellitus were excluded from the study. In all patients was performed EchoCG (ASE/EAE recommendations 2005) and were evaluated plasma levels of aldosteron, angiotensin 2, angiotensin-converting enzyme (ACE), tissue inhibitor of metalloproteinases-1 (TIMP-1), IGF-1. HF NYHA functional class was determined by using the 6MWT. Statistical significance was defined at the level of methods for p<0,05. Results of the study are shown in Table 1. Thus, the results of the study show that interstitial myocardium fibrosis and activity of RAAS were significantly higher in patients with concentric hypertrophy and eccentric hypertrophy. LV remodelling, RAAS and fibrosis ParametersLV geometry modelNormal geometryConcentric remodellingEccentric hypertrophyConcentric hypertrophyn=148n=36n=50n=52Angiothensin 2, pg/ml37.8 (11.6)39.0 (16.4)47.4 (13.4)57.7 (10.5)*†ACE, u/l45.8 (16.7)38.9 (17.1)62.5 (35.3)*73.8 (25.9)*Aldosterone, pg/ml121.5 (27.5)95.8 (43.4)144.5 (38.3)*143.2 (38.9)*TIMP-1, ng/ml276.9 (80.3)249.8 (83.2)359.9 (119.5)*‡403.1 (128.5)*‡IGF-1, ng/ml162.6 (23.6)†158.3 (18.9)†139.9 (19.7)155.5 (24.5)†Interstitial collagen volume fraction, %3.03 (0.78)3.66 (0.96)*4.47 (0.98)*‡5.34 (0.97)*†‡ *- p<0.05 in comparison with patients with normal geometry; † - p<0.05 in comparison with patients with eccentric hypertrophy; ‡ - p<0.05 in comparison with patients with concentric remodelling. Results are shown in M (SD).
Published: 2014
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20. Poster session Wednesday 11 December all day display: 11/12/2013, 09:30-16:00 * Location: Poster area

Author: Bertrand, PB, Grieten, L, Smeets, C, Verbrugge, FH, Mullens, W, Vrolix, M, Rivero-Ayerza, M, Verhaert, D, Vandervoort, P, Tong, L, Ramalli, A, Tortoli, P, Dhoge, J, Bajraktari, G, Lindqvist, P, Henein, MY, Obremska, M, Boratynska, MB, Kurcz, JK, Zysko, DZ, Baran, TB, Klinger, MK, Darahim, K, Mueller, H, Carballo, D, Popova, N, Vallee, J-P, Floria, M, Chistol, R, Tinica, G, Grecu, M, Rodriguez Serrano, M, Osa-Saez, A, Rueda-Soriano, J, Buendia-Fuentes, F, Domingo-Valero, D, Igual-Munoz, B, Alonso-Fernandez, P, Quesada-Carmona, A, Miro-Palau, V, Palencia-Perez, M, Bech-Hanssen, O, Polte, CL, Lagerstrand, K, Janulewicz, M, Gao, S, Erdogan, E, Akkaya, M, Bacaksiz, A, Tasal, A, Sonmez, O, Turfan, M, Kul, S, Vatankulu, MA, Uyarel, H, Goktekin, O, Mincu, RI, Magda, LS, Mihaila, S, Florescu, M, Mihalcea, D, Enescu, OE, Chiru, A, Popescu, B, Tiu, C, Vinereanu, D, 112/2011, Research grant, Broch, K, Kunszt, G, Massey, R, De Marchi, SF, Aakhus, S, Gullestad, L, Urheim, S, Yuan, L, Feng, JL, Jin, XY, Bombardini, T, Casartelli, M, Simon, D, Gaspari, MG, Procaccio, F, Hasselberg, NE, Haugaa, KH, Brunet, A, Kongsgaard, E, Donal, E, Edvardsen, T, Sahin, TAYLAN, Yurdakul, S, Cengiz, BETUL, Bozkurt, AYSEN, Aytekin, SAIDE, Cesana, F, Spano, F, Santambrogio, G, Alloni, M, Vallerio, P, Salvetti, M, Carerj, S, Gaibazzi, N, Rigo, F, Moreo, A, Group, APRES Collaborative, Wdowiak-Okrojek, K, Michalski, B, Kasprzak, JD, Shim, A, Lipiec, P, Generati, G, Pellegrino, M, Bandera, F, Donghi, V, Alfonzetti, E, Guazzi, M, Marcun, R, Stankovic, I, Farkas, J, Vlahovic-Stipac, A, Putnikovic, B, Kadivec, S, Kosnik, M, Neskovic, AN, Lainscak, M, Iliuta, L, Szymanski, P, Lipczynska, M, Klisiewicz, A, Sobieszczanska-Malek, M, Zielinski, T, Hoffman, P, Gjerdalen, G F, Hisdal, J, Solberg, EE, Andersen, TE, Radunovic, Z, Steine, K, Svanadze, A, Poteshkina, N, Krylova, N, Mogutova, P, Shim, A, Kasprzak, JD, Szymczyk, E, Wdowiak-Okrojek, K, Michalski, B, Stefanczyk, L, Lipiec, P, Benedek, T, Matei, C, Jako, B, Suciu, ZS, Benedek, I, Yaroshchuk, N A, Kochmasheva, V V, Dityatev, V P, Kerbikov, O B, Przewlocka-Kosmala, M, Orda, A, Karolko, B, Mysiak, A, Kosmala, W, Rechcinski, T, Wierzbowska-Drabik, K, Lipiec, P, Chmiela, M, Kasprzak, JD, Aziz, A, Hooper, J, Rayasamudra, S, Uppal, H, Asghar, O, Potluri, R, Zaroui, A, Mourali, MS, Rezine, Z, Mbarki, S, Jemaa, M, Aloui, H, Mechmeche, R, Farhati, A, Gripari, P, Maffessanti, F, Tamborini, G, Muratori, M, Fusini, L, Vignati, C, Bartorelli, AL, Alamanni, F, Agostoni, PG, Pepi, M, Ruiz Ortiz, M, Mesa, D, Delgado, M, Seoane, T, Carrasco, F, Martin, M, Mazuelos, F, Suarez De Lezo Herreros De Tejada, J, Romero, M, Suarez De Lezo, J, Brili, S, Stamatopoulos, I, Misailidou, M, Chrisochoou, C, Christoforatou, E, Stefanadis, C, Ruiz Ortiz, M, Mesa, D, Delgado, M, Martin, M, Seoane, T, Carrasco, F, Ojeda, S, Segura, J, Pan, M, Suarez De Lezo, J, Cammalleri, V, Ussia, GP, Muscoli, S, Marchei, M, Sergi, D, Mazzotta, E, Romeo, F, Igual Munoz, B, Bel Minguez, ABM, Perez Guillen, MPG, Maceira Gonzalez, AMG, Monmeneu Menadas, JVMM, Hernandez Acuna, CHA, Estornell Erill, JEE, Lopez Lereu, PLL, Francisco Jose Valera Martinez, FJVM, Montero Argudo, AMA, Sunbul, M, Akhundova, A, Sari, I, Erdogan, O, Mutlu, B, Cacicedo, A, Velasco Del Castillo, S, Anton Ladislao, A, Aguirre Larracoechea, U, Rodriguez Sanchez, I, Subinas Elorriaga, A, Oria Gonzalez, G, Onaindia Gandarias, J, Laraudogoitia Zaldumbide, E, Lekuona Goya, I, Ding, W, Zhao, Y, Lindqvist, P, Nilson, J, Winter, R, Holmgren, A, Ruck, A, Henein, MY, Attenhofer Jost, C H, Soyka, R, Oxenius, A, Kretschmar, O, Valsangiacomo Buechel, ER, Greutmann, M, Weber, R, Keramida, K, Kouris, N, Kostopoulos, V, Karidas, V, Damaskos, D, Makavos, G, Paraskevopoulos, K, Olympios, CD, Eskesen, K, Olsen, NT, Fritz-Hansen, T, Sogaard, P, Cameli, M, Lisi, M, Righini, FM, Curci, V, Massoni, A, Natali, B, Maccherini, M, Chiavarelli, M, Massetti, M, Mondillo, S, Mabrouk Salem Omar, A, Ahmed Abdel-Rahman, M, Khorshid, H, Rifaie, O, Santoro, C, Santoro, A, Ippolito, R, De Palma, D, De Stefano, F, Muscariiello, R, Galderisi, M, Squeri, A, Censi, S, Baldelli, M, Grattoni, C, Cremonesi, A, Bosi, S, Saura Espin, D, Gonzalez Canovas, C, Gonzalez Carrillo, J, Oliva Sandoval, MJ, Caballero Jimenez, L, Espinosa Garcia, MD, Garcia Navarro, M, Valdes Chavarri, M, De La Morena Valenzuela, G, Ryu, SK, Shin, DG, Son, JW, Choi, JH, Goh, CW, Choi, JW, Park, JY, Hong, GR, Sklyanna, O, Yuan, L, Yuan, L, Planinc, I, Bagadur, G, Ljubas, J, Baricevic, Z, Skoric, B, Velagic, V, Bijnens, B, Milicic, D, Cikes, M, Gospodinova, M, Chamova, T, Guergueltcheva, V, Ivanova, R, Tournev, I, Denchev, S, Ancona, R, Comenale Pinto, S, Caso, P, Arenga, F, Coppola, MG, Calabro, R, Neametalla, H, Boitard, S, Hamdi, H, Planat-Benard, V, Casteilla, L, Li, Z, Hagege, AA, Mericskay, M, Menasche, P, Agbulut, O, Merlo, M, Stolfo, D, Anzini, M, Negri, F, Pinamonti, B, Barbati, G, Di Lenarda, A, Sinagra, G, Stolfo, D, Merlo, M, Pinamonti, B, Gigli, M, Poli, S, Porto, A, Di Nora, C, Barbati, G, Di Lenarda, A, Sinagra, G, Coppola, C, Piscopo, G, Cipresso, C, Rea, D, Maurea, C, Esposito, E, Arra, C, Maurea, N, Nemes, A, Kalapos, A, Domsik, P, Forster, T, Voilliot, D, Huttin, O, Vaugrenard, T, Schwartz, J, Sellal, J-M, Aliot, E, Juilliere, Y, Selton-Suty, C, Sanchez Millan, P J, Cabeza Lainez, P, Castillo Ortiz, J, Chueca Gonzalez, EM, Gheorghe, L, Fernandez Garcia, P, Herruzo Rojas, MS, Del Pozo Contreras, R, Fernandez Garcia, M, Vazquez Garcia, R, Rosca, M, Popescu, BA, Botezatu, D, Calin, A, Beladan, CC, Gurzun, M, Enache, R, Ginghina, C, Farouk, H, Al-Maimoony, T, Alhadad, A, El Serafi, M, Abdel Ghany, M, Poorzand, H, Mirfeizi, SZ, Javanbakht, A, center, Preventive Cardiovascular care research, center, Lupus Research, sciences, Mashhad university of medical, Tellatin, S, Famoso, G, Dassie, F, Martini, C, Osto, E, Maffei, P, Iliceto, S, Tona, F, Radunovic, Z, Steine, KS, Jedrzejewska, I, Braksator, W, Krol, W, Swiatowiec, A, Sawicki, J, Kostarska-Srokosz, E, Dluzniewski, M, Maceira Gonzalez, A M, Cosin-Sales, J, Diago, JL, Aguilar, J, Ruvira, J, Monmeneu, J, Igual, B, Lopez-Lereu, MP, Estornell, J, Olszanecka, A, Dragan, A, Kawecka-Jaszcz, K, Czarnecka, D, Scholz, F, Gaudron, PD, Hu, K, Liu, D, Florescu, C, Herrmann, S, Bijnens, B, Ertl, G, Stoerk, S, Weidemann, F, Krestjyaninov, M, Razin, VA, Gimaev, RH, Bogdanovic, Z, Burazor, I, Deljanin Ilic, M, Peluso, D, Muraru, D, Cucchini, U, Mihaila, S, Casablanca, S, Pigatto, E, Cozzi, F, Punzi, L, Badano, LP, Iliceto, S, Zhdanova, E, Rameev, VV, Safarova, AF, Moisseyev, SV, Kobalava, ZD, Magnino, C, Omede, P, Avenatti, E, Presutti, D, Losano, I, Moretti, C, Bucca, C, Gaita, F, Veglio, F, Milan, A, Bellsham-Revell, H, Bell, AJ, Miller, OI, Simpson, JM, Hwang, YM, Kim, GH, Jung, MH, Woo, GH, Medicine, Department of Internal, Hospital, St.Vincents, Korea, The Catholic University of, Suwon, Division of Cardiology, Repu, Driessen, MMP, Leiner, T, Schoof, PH, Breur, JMPJ, Sieswerda, GT, Meijboom, FJ, Bellsham-Revell, H, Hayes, N, Anderson, D, Austin, BC, Razavi, R, Greil, GF, Simpson, JM, Bell, AJ, Zhao, XX, Xu, XD, Qin, YW, Szmigielski, C A, Styczynski, G, Sobczynska, M, Placha, G, Kuch-Wocial, A, Ikonomidis, I, Voumbourakis, A, Triantafyllidi, H, Pavlidis, G, Varoudi, M, Papadakis, I, Trivilou, P, Paraskevaidis, I, Anastasiou-Nana, M, Lekakis, I, Kong, WILL, Yip, JAMES, Ling, LH, Milan, A, Tosello, F, Leone, D, Bruno, G, Losano, I, Avenatti, E, Sabia, L, Veglio, F, Zaborska, B, Baran, J, Pilichowska-Paszkiet, E, Sikora-Frac, M, Michalowska, I, Kulakowski, P, Budaj, A, Mega, S, Bono, MC, De Francesco, V, Castiglione, I, Ranocchi, F, Casacalenda, A, Goffredo, C, Patti, G, Di Sciascio, G, Musumeci, F, Kennedy, M, Waterhouse, DF, Sheahan, R, Foley, DF, Mcadam, BF, Ancona, R, Comenale Pinto, S, Caso, P, Arenga, F, Coppola, MG, Calabro, R, Remme, E W, Smedsrud, M K, Hasselberg, N E, Smiseth, O A, Edvardsen, T, Halmai, L, Nemes, A, Kardos, A, Neubauer, S, Degiovanni, A, Baduena, L, Dellera, G, Occhetta, E, Marino, P, Hotchi, J, Yamada, H, Nishio, S, Bando, M, Hayashi, S, Hirata, Y, Amano, R, Soeki, T, Wakatsuki, T, Sata, M, Lamia, B, Molano, LC, Viacroze, C, Cuvelier, A, Muir, JF, Lipczynska, M, Piotr Szymanski, PS, Anna Klisiewicz, AK, Lukasz Mazurkiewicz, LM, Piotr Hoffman, PH, Van T Sant, J, Wijers, SC, Ter Horst, IAH, Leenders, GE, Cramer, MJ, Doevendans, PA, Meine, M, Hatam, N, Goetzenich, A, Aljalloud, A, Mischke, K, Hoffmann, R, Autschbach, R, Sikora-Frac, M, Zaborska, B, Maciejewski, P, Bednarz, B, Budaj, A, Evangelista, A, Torromeo, C, Pandian, NG, Nardinocchi, P, Varano, V, Schiariti, M, Teresi, L, Puddu, PE, Storve, S, Dalen, H, Snare, SR, Haugen, BO, Torp, H, Fehri, W, Mahfoudhi, H, Mezni, F, Annabi, MS, Taamallah, K, Dahmani, R, Haggui, A, Hajlaoui, N, Lahidheb, D, Haouala, H, Colombo, A, Carminati, MC, Maffessanti, F, Gripari, P, Pepi, M, Lang, RM, Caiani, EG, Walker, JR, Abadi, S, Agmon, Y, Carasso, S, Aronson, D, Mutlak, D, Lessick, J, Saxena, A, Ramakrishnan, S, Juneja, R, Ljubas, J, Reskovic Luksic, V, Matasic, R, Pezo Nikolic, B, Lovric, D, Separovic Hanzevacki, J, Quattrone, A, Zito, C, Alongi, G, Vizzari, G, Bitto, A, De Caridi, G, Greco, M, Tripodi, R, Pizzino, G, Carerj, S, Ibrahimi, P, Jashari, F, Johansson, E, Gronlund, C, Bajraktari, G, Wester, P, Henein, MY, Kosmala, W, Marwick, TH, Souza, J R M, Zacharias, L G T, Geloneze, B, Pareja, J C, Chaim, A, Nadruz, W JR, Coelho, O R, Apostolovic, S, Stanojevic, D, Jankovic-Tomasevic, R, Salinger-Martinovic, S, Djordjevic-Radojkovic, D, Pavlovic, M, Tahirovic, E, Musial-Bright, L, Lainscak, M, Duengen, HD, group, CIBIS ELD study, Filipiak, D, Kasprzak, JD, and Lipiec, P
Abstract: Purpose: With the advent of percutaneous transcatheter device closures in congenital heart defects and the emergence of percutaneous left atrial appendage closure, there is an increasingly important role for echocardiographic guidance and control of device position and function. Disc occluder devices frequently present as an unexplained ‘figure-of-8’ on echocardiography. The aim of this study was to clarify this ‘figure-of-8’ display and to relate its morphology to transducer position and device type. Methods: A mathematical model was developed to resemble disc occluder geometry and to allow a numerical simulation of the echocardiographic appearance. In addition, we developed an in vitro set-up for echocardiographic analysis of various disc occluders and various transducer positions. Results: In the mathematical model of an epitrochoid curve (closely resembling disc occluder geometry) a ‘figure-of-8’ display is obtained when emphasizing points with tangent vector perpendicular to the direction of ultrasound waves. Decreasing imaging depth results in a more asymmetric ‘figure-of-8’, with small upper part and wide lower part. Clinical and in vitro data are in close agreement with these results (Figure 1). Furthermore a ‘figure-of-8’ display is only obtained in a coronal imaging position, and is similar for different commercially available disc occluder types. Conclusions: The ‘figure-of-8’ display in the ultrasound image of a disc occluder is an imaging artifact due to the specific ‘epitrochoidal’ geometry of a deployed device and its interaction with ultrasound waves. The morphology of the ‘figure-of-8’ depends on transducer position, i.e. imaging depth, and is similar for different device types. Figure 1 Impact of imaging depth
Published: 2013
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21. Poster session Friday 13 December - AM: 13/12/2013, 08:30-12:30 * Location: Poster area

Author: Gertsen, M, Nemes, A, Szolnoky, G, Altmayer, A, Gavaller, H, Kemeny, L, Forster, T, Park, J R, Jo, SY, Kim, KH, Kho, JS, Kwack, CH, Hwang, JY, Popovic, D, Ostojic, MC, Petrovic, M, Vujisic-Tesic, B, Arandjelovic, A, Banovic, M, Vukcevic, V, Petrovic, I, Popovic, B, Damjanovic, S, Placido, R, Marta, L, Ramalho, AR, Nobre Menezes, M, Cortez-Dias, N, Martins, S, Goncalves, S, Almeida, AG, Silva-Marques, J, Nunes-Diogo, A, Germanakis, I, Kakouri, P, Karachaliou, M, Vassilaki, M, Chatzi, L, Roumeliotaki, T, Kogevinas, M, Horst, J-P, Kelter-Kloepping, A, Koerperich, H, Barth, P, Haas, NA, Kececioglu, D, Laser, KT, Laser, KT, Horst, J-P, Kelter-Kloepping, A, Barth, P, Haas, NA, Kececioglu, D, Koerperich, H, Samiei, N, Nabati, M, Azari-Jafari, M, Vakili-Zarch, A, Parsaee, M, Haghjoo, M, Ahmed, A J, Val-Mejias, J E, Von Bulow, F M, Baltussen, E J M, Darban, AM, Claus, P, Voigt, JU, Rodriguez Munoz, DA, Moya Mur, JL, Gonzalez, A, Garcia Martin, A, Becker Filho, D, Fernandez Santos, S, Lazaro Rivera, C, Recio Vazquez, M, Fernandez Golfin, C, Zamorano Gomez, JL, Bandera, F, Pellegrino, M, Generati, G, Alfonzetti, E, Donghi, V, Castelvecchio, S, Garatti, A, Menicanti, L, Guazzi, M, Kowalik, E, Klisiewicz, A, Hoffman, P, Kim, EJ, Cho, I J, Oh, J, Chang, HJ, Park, J, Shin, S, Shim, CY, Hong, GR, Ha, JW, Chung, N, Park, JH, Lee, HS, Kim, HS, Ahn, KT, Kim, JH, Lee, JH, Choi, SW, Jeong, JO, Seong, IW, Holzendorf, V, Gelbrich, G, Wachter, R, Loeffler, M, Pieske, BM, Broda, A, Edelmann, F, Failure, German Competence Network for Heart, Kim, YH, Kim, DH, Kim, SH, Ahn, JC, Song, WH, Hashimoto, G, Suzuki, M, Yoshikawa, H, Otsuka, T, Kusunose, Y, Nakamura, M, Sugi, K, De Knegt, M C, Biering-Sorensen, T, Sogaard, P, Sivertsen, J, Jensen, JS, Mogelvang, R, Murbraech, K, Smeland, KH, Holte, H, Loge, JH, Kiserud, CE, Aakhus, S, Peteiro, J, Gargallo-Fernandez, P, Garcia-Guimaraes, M, Bouzas-Mosquera, A, Yanez-Wronenburger, JC, Martinez-Ruiz, D, Castro-Beiras, A, Trzcinski, PT, Jaskowski, MJ, Nowak, JN, Pawlus, MP, Figiel, LF, Kasprzak, JDK, Lipiec, PL, Zhong, L, Su, Y, Teo, SK, Le, TT, Tan, RS, Tesic, M, Djordjevic-Dikic, A, Giga, V, Jovanovic, I, Paunovic, I, Petrovic, MT, Trifunovic, D, Beleslin, B, Stepanovic, J, Vujisic-Tesic, B, Parato, V M, Partemi, M, Nardini, E, Pasanisi, E, Park, T-H, Lee, J-E, Lee, D-H, Park, J-S, Park, K, Kim, M-H, Kim, Y-D, Vegsundvag, J, Holte, E, Wiseth, R, Hegbom, K, Hole, T, Fusini, L, Tamborini, G, Ghulam Ali, S, Muratori, M, Gripari, P, Cefalu, C, Maffessanti, F, Celeste, F, Alamanni, F, Pepi, M, Negrea, SL, Alexandrescu, C, Rossi, P, Iacuzio, L, Dreyfus, G, Moatemri, F, Mahdhaoui, A, Bouraoui, H, Ernez, S, Jeridi, G, Yuan, L, Feng, JL, Jin, X Y, Seoane Garcia, T, Delgado Ortega, M, Mesa Rubio, D, Ruiz Ortiz, M, Martin Hidalgo, M, Carrasco Avalos, F, Casares Mediavilla, J, Alados, P, Lopez Granados, A, Suarez De Lezo Cruz Conde, J, Mutuberria Urdaniz, M, Rodriguez-Palomares, JF, Baneras-Rius, JF, Acosta-Velez, JG, Buera-Surribas, I, Gonzalez-Alujas, MT, Teixido, G, Evangelista, A, Tornos, P, Garcia-Dorado, D, Iliuta, L, Boerlage-Van Dijk, K, Van Riel, ACMJ, De Bruin-Bon, HACM, Wiegerinck, EMA, Koch, KT, Vis, MM, Meregalli, PG, Piek, JJ, Bouma, BJ, Baan, J, Enache, R, Muraru, D, Piazza, R, Popescu, BA, Coman, M, Calin, A, Rosca, M, Beladan, CC, Nicolosi, GL, Ginghina, C, Song, JM, Kim, JJ, Ha, TY, Jung, SH, Hwang, IS, Lee, IC, Sun, BJ, Kim, DH, Kang, DH, Song, JK, Sturmberger, T, Ebner, CE, Aichinger, J, Tkalec, W, Niel, J, Steringer-Mascherbauer, R, Kabicher, G, Winter, S, Nesser, HJ, Hofmann-Bowman, M, Lin Yan, LY, Puri, TP, Chin, C W L, Doris, M, Shah, A, Mills, N, Semple, S, Prasad, S, White, A, Dweck, M, Newby, D, Debonnaire, P, Al Amri, I, Leong, DP, Joyce, E, Katsanos, S, Kamperidis, V, Schalij, MJ, Bax, JJ, Ajmone Marsan, N, Delgado, V, Cerin, G, Popa, B A, Lanzillo, G, Benea, D, Karazanishvili, L, Diena, M, Dedobbeleer, C, Schnell, F, Jotrand, E, El Mourad, M, Thebault, C, Plein, D, 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AR, SUNSHINE, Zito, C, Crea, P, Cusma Piccione, M, Vriz, O, Bitto, A, Minisini, R, Madaffari, A, Acri, E, Oteri, A, Carerj, S, Leggio, S, Buccheri, S, Tamburino, C, Monte, I P, Mihalcea, D, Florescu, M, Enescu, OA, Magda, LS, Radu, E, Acasandrei, AM, Balanescu, P, Rimbas, RC, Jinga, D, Vinereanu, D, 112/2011, Research grant, Miyoshi, T, Tanaka, H, Kaneko, A, Matsumoto, K, Imanishi, J, Motoji, Y, Mochizuki, Y, Minami, H, Kawai, H, Hirata, K, Ryu, SK, Shin, DG, Son, JW, Choi, JH, Goh, CW, Choi, JW, Park, JY, Hong, GR, Le Page, P, Mitchell, ARJ, Maclachlan, HI, Hurry, RW, Villagraz Tecedor, L, Jimenez Lopez Guarch, C, Alonso Chaterina, S, Mayordomo Gomez, S, Blazquez Arrollo, L, Lombera Romero, F, Lopez Melgar, B, Escribano Subias, MP, Lichodziejewska, B, Kurnicka, K, Goliszek, S, Kostrubiec, M, Dzikowska Diduch, O, Krupa, M, Grudzka, K, Ciurzynski, M, Palczewski, P, Pruszczyk, P, Lovric, D, Carmona, C, Bergerot, C, Schnell, F, Thibault, H, Barthelet, M, Ninet, J, Revel, D, Croisille, P, 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Chrzanowski, L, Tomaszewski, A, Sinkiewicz, W, Wojciechowska, C, Aggeli, C, Felekos, I, Stergiou, P, Roussakis, G, Kakiouzi, V, Kastellanos, S, Koutagiar, I, Stefanadis, C, Bouzas Mosquera, A, Peteiro, J, Alvarez-Garcia, N, Broullon, FJ, Garcia-Guimaraes, MM, Martinez-Ruiz, D, Yanez-Wonenburger, JC, Bouzas-Zubeldia, B, Fabregas, R, Castro-Beiras, A, Brugger, N, Huerzeler, M, Wustmann, K, Wahl, A, Steck, H, Seiler, C, Sarwar, R, Malhotra, A, Wong, KC, Betts, TR, Bashir, Y, Rajappan, K, Newton, JD, Casanova Rodriguez, C, Cano Carrizal, R, Iglesias Del Valle, D, Martin Penato Molina, A, Garcia Garcia, A, Prieto Moriche, E, Alvarez Rubio, J, Paredes Gonzalez, B, De Juan Baguda, J, Plaza Perez, I, Van Den Oord, SCH, Akkus, Z, Roeters Van Lennep, JE, Bosch, JG, Van Der Steen, AFW, Sijbrands, EJG, Schinkel, AFL, Muraru, D, Calore, C, Badano, LP, Melacini, C, Mihaila, S, Peluso, D, Puma, L, Kocabay, G, Rizzon, G, Iliceto, S, Bochard Villanueva, B, Paya-Serrano, R, Garcia-Gonzalez, P, Fabregat-Andres, O, Perez-Bosca, JL, Cubillos-Arango, A, Ferrando-Beltran, M, Chacon-Hernandez, N, Albiach-Montanana, C, Ridocci-Soriano, F, Ancona, R, Comenale Pinto, S, Caso, P, Arenga, F, Coppola, MG, Calabro, R, Tarr, A, Stoebe, S, Pfeiffer, D, Hagendorff, A, Hollekim, SM, Bjorgaas, MR, Tjonna, AE, Wisloff, U, Ingul, CB, (CERG), Cardiac Exercise Research Group, Oreto, L, Zito, C, Cusma-Piccione, M, Calabro, MP, Todaro, MC, Vita, GL, Messina, S, Vita, G, Sframeli, M, Carerj, S, Remoli, R, Lamberti, F, Bellini, C, Mercurio, M, Dottori, S, Bellusci, F, Mazzuca, V, Gaspardone, A, Rimbas, RC, Enescu, OA, Mihaila, S, Ciobanu, A, Vinereanu, D, Henri, C, Magne, J, Dulgheru, R, Laaraibi, S, Voilliot, D, Kou, S, Pierard, L, Lancellotti, P, Wellnhofer, E, Kriatselis, C, Gerds-Li, H, Furundzija, VESNA, Thanabalasingam, U, Fleck, E, Graefe, M, Kouris, N, Keramida, K, Karidas, V, Kostopoulos, V, Kostakou, P, Mprempos, G, Olympios, CD, Duchateau, N, Giraldeau, G, Gabrielli, L, Penela, D, Evertz, R, Mont, L, Brugada, J, Berruezo, A, Bijnens, BH, Sitges, M, Bernard, A, Donal, E, Reynaud, A, Schnell, F, Daubert, JC, Leclercq, C, Hernandez, A, Keramida, K, Kouris, N, Kostopoulos, V, Karidas, V, Dagre, A, Ntarladimas, I, Damaskos, D, Stamatelatou, M, Olympios, CD, Panetta, G L, Peraldo Neja, C, Urbano Moral, JA, Evangelista, A, Azzolini, P, Gaudio, C, Pandian, NG, Barbier, P, Mirea, O, Savioli, G, Cefalu, C, Guglielmo, M, Fusini, L, Maltagliati, A, Hamdy, AM, Fereig, HM, Nabih, MA, Abdel-Aziz, A, Ali, AA, Buccheri, S, Mangiafico, S, Leggio, S, B, VE, Tropea, L, Tamburino, C, Monte, I P, Garcia-Gonzalez, P, Chacon-Hernandez, N, Cozar-Santiago, P, Fabregat-Andres, O, Sanchez-Jurado, R, Higueras-Ortega, L, Albiach-Motanana, C, Perez-Bosca, JL, Paya-Serrano, R, Ridocci-Soriano, F, Flori, M, Valette, F, Guijarro, D, Pallardy, A, Le Tourneau, T, Kraeber-Bodere, F, Piriou, N, Saxena, A, Ramakrishnan, S, Tulunay Kaya, C, Ongun, A, Kilickap, M, Candemir, B, Altin, AT, Gerede, M, Ozcan, OU, Erol, C, Yue, WS, Yang, F, Huang, D, Gu, P, Luo, Y, Lv, Z, Siu, CW, Tse, HF, Yiu, KH, Saura Espin, D, Lopez Cuenca, A, Espinosa Garcia, MD, Oliva Sandoval, MJ, Lopez Ruiz, M, Gonzalez Carrillo, J, Garcia Navarro, MJ, Valdes Chavarri, M, De La Morena Valenzuela, G, Gustafsson, U, Spuhler, JH, Hoffman, J, Brodin, LÅ, Kisko, A, Dernarova, L, Hudakova, A, Santova, T, Jakubikova, M, Mikulak, M, Horlenko, O, Kishko, N, Svystak, V, Shyp, A, Faden, G, Gaibazzi, N, Rigo, F, Mureddu, GF, Moreo, A, Bussadori, G, Facchetti, R, Cesana, F, Giannattasio, C, Faggiano, P, and group, APRES collaborative
Abstract: Pulmonary vascular dysfunction is claimed to be a contributor to the development of pulmonary hypertension (PH). Impaired systemic vascular reactivity is one of the essential factors in the pathogenesis of cardiovascular disease. The aim of the investigation was to study whether there is any association between systemic vascular function and pulmonary artery pressure (PAP) in patients who have associated causes for PH development, such as coronary heart disease (CHD) and chronic obstructive pulmonary disease (COPD). Methods: The brachial artery vasodilator responses were measured by the ultrasound technique in twenty patients with mild to moderate COPD (group I) and twenty age–matched and COPD stage-matched patients who had past history of myocardial infarction (NYHA II) (group II).Conventional echocardiographic variables were measured in the said patients too. Results: Both flow-mediated dilatation (FMD) and nitrate-mediated dilatation (NMD) were significantly lower, and PAP was significantly higher in the group II patients compared to the same parameters of group I patients. NMD was inversely correlated with PAP (r=-0.7, p=0.02) in group I patients. There was no interrelation between FMD and PAP in patients from group I. Neither FMD nor NMD were correlated with PAP in group II patients. A significant positive correlation between PAP and left ventricular mass index (r=0.8, p=0.003) was revealed in the said patients as well. Conclusions: Attenuated vasodilator response of brachial artery to nitroglycerine is associated with PAP elevation in COPD patients. PH is closely related to cardiac remodeling in COPD patients in whom CHD developed. These data suggest different "stages" of vascular and cardiac remodeling in patients with COPD alone and in coexistence with CHD. The obtained data can be useful in the selection of treatment as regards these patient categories.
Published: 2013
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22. Monomodular and multifunctional processive endocellulases: implications for swine nutrition and gut microbiome.

Author: Fan MZ, Cheng L, Wang M, Chen J, Fan W, Jashari F, and Wang W
Abstract: Poor efficiency of dietary fibre utilization not only limits global pork production profit margin but also adversely affects utilization of various dietary nutrients. Poor efficiency of dietary nutrient utilization further leads to excessive excretion of swine manure nutrients and results in environmental impacts of emission of major greenhouse gases (GHG), odor, nitrate leaching and surface-water eutrophication. Emission of the major GHG from intensive pork production contributes to global warming and deteriorates heat stress to pigs in tropical and sub-tropical swine production. Exogenous fibre enzymes of various microbial cellulases, hemicellulases and pectinases have been well studied and used in swine production as the non-nutritive gut modifier feed enzyme additives in the past over two decades. These research efforts have aimed to improve growth performance, nutrient utilization, intestinal fermentation as well as gut physiology, microbiome and health via complementing the porcine gut symbiotic microbial fibrolytic activities towards dietary fibre degradation. The widely reported exogenous fibre enzymes include the singular use of respective cellulases, hemicellulases and pectinases as well as their multienzyme cocktails. The currently applied exogenous fibre enzymes are largely limited by their inconsistent in vivo efficacy likely due to their less defined enzyme stability and limited biochemical property. More recently characterized monomodular, multifunctional and processive endoglucanases have the potential to be more efficaciously used as the next-generation designer fibre biocatalysts. These newly emerging multifunctional and processive endoglucanases have the potential to unleash dietary fibre sugar constituents as metabolic fuels and prebiotics, to optimize gut microbiome, to maintain gut permeability and to enhance performance in pigs under a challenged environment as well as to parallelly unlock biomass to manufacture biofuels and biomaterials., (© 2024. The Author(s).)
Published: 2024
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23. Risk Factors and Clinical Outcomes of COVID-19 Infection in Multiple Sclerosis Patients: A Retrospective Study from a Single Center in Kosovo.

Author: Komoni E, Jashari F, Boshnjaku D, Myftiu B, Pushka M, Blyta A, and Nallbani-Komoni R
Subjects: Female, Humans, Male, Antibodies, Viral, Blindness, Kosovo epidemiology, Retrospective Studies, Risk Factors, Vitamin D, Adult, Middle Aged, COVID-19 complications, Multiple Sclerosis complications
Abstract: BACKGROUND Multiple sclerosis (MS) is treated with disease-modifying therapies (DMTs) that can increase susceptibility to viral infections. This retrospective study aimed to evaluate the presentation, management, and outcomes of patients with MS on DMTs admitted with symptoms of COVID-19 to a single center in Prishtina, Kosovo between March 2020 and April 2022. MATERIAL AND METHODS In this observational, single-center study, we included 282 patients with MS (mean age 37.8±11, 64.9% females), of whom 272 (96.4%) had confirmed COVID-19 infection, either through the presence of antibodies in the serum or a positive PCR test. RESULTS Most patients with COVID-19 infection were either asymptomatic or mildly symptomatic, while 11 patients were hospitalized due to moderate to severe symptoms. Among those with severe infection, 2 patients have died. Patients with moderate and severe COVID-19 had more advanced MS disease (P=0.001) and higher disability scales (P<0.001). In a logistic regression analysis, advanced MS remained significantly associated with worse symptoms, even after adjusting for other risk factors, with a relative risk (RR) of 2.8 (95% CI=1.1-6.6, P=0.018). MS patients on anti-CD20 DMTs more frequently experienced moderate and severe symptoms (RR=2.1, 95% CI=1.1-4.0, P=0.012). Anti-SARS-CoV-2 IgG was also lower in patients treated with anti-CD20. Notably, patients receiving vitamin D supplementation experienced a lower frequency of moderate to severe symptoms (P=0.007). CONCLUSIONS Patients with advanced MS exhibiting higher disability scales and those on anti-CD20 therapy faced an increased risk of experiencing more pronounced symptoms after COVID-19 infection. Patients on vitamin D supplementation had better clinical outcomes.
Published: 2024
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24. Baló Concentric Sclerosis Mimicking Encephalitis with Seizures and Progressive Aphasia in a 26-Year-Old Woman: A Challenging Diagnostic Dilemma.

Author: Shala N, Tolaj I, Jashari F, Malazogu E, Shala A, Bajraktari G, Ahmetgjekaj I, and Dreshaj S
Abstract: Introduction: Baló's concentric sclerosis (BCS) is a rare subtype of multiple sclerosis characterized by inflammatory demyelination within the central nervous system., Case Presentation: This case report presents a challenging diagnostic scenario involving a 26-year-old woman diagnosed with BCS. Despite treatment, her condition did not ameliorate, and magnetic resonance imaging (MRI) findings remained unchanged. A subsequent stereotactic biopsy revealed tumefactive Balo disease, highlighting the intricate diagnostic and therapeutic issues surrounding BCS., Conclusion: The juxtacortical location of the BCS lesion, as observed in our case, suggests an unfavourable prognosis due to treatment-resistant seizures., Competing Interests: The authors have no conflicts of interest to declare., (© 2023 The Author(s). Published by S. Karger AG, Basel.)
Published: 2023
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25. EVALUATION OF VISION-RELATED QUALITY OF LIFE IN PATIENTS AFTER VITRECTOMY FOLLOWING IDIOPATHIC EPIRETINAL MEMBRANE.

Author: Bajraktari G, Jukić T, Vukojević N, Oroz M, Bertetić AR, and Jashari F
Subjects: Humans, Vitrectomy, Quality of Life, Visual Acuity, Retina, Sodium Chloride, Vision Disorders, Epiretinal Membrane surgery
Abstract: Purpose: To evaluate the impact of different intraocular tamponades on the vision-related quality of life (VRQOL) after idiopathic epiretinal membrane (IEM) surgery with epiretinal membrane peeling., Methods: We prospectively enrolled 50 patients diagnosed with IEM who underwent pars plana vitrectomy. Patients were consecutively assigned to either the air tamponade (air) group (25 patients) or the balanced salt solution (BSS) tamponade group (25 patients). The following data were collected before and after surgery and compared between the two groups: VRQOL, best-corrected visual acuity, intraocular pressure, metamorphopsia, contrast sensitivity, and central macular thickness., Results: Pars plana vitrectomy was performed in 50 eyes. At baseline, there were no significant differences between the two groups. At 6 months postoperatively, VRQOL ( P < 0.001), best-corrected visual acuity ( P < 0.001), central macular thickness ( P < 0.001), contrast sensitivity ( P < 0.001), and metamorphopsia ( P < 0.001) improved significantly in comparison with baseline, without significant differences between the air tamponade and BSS groups., Conclusion: Removing IEM significantly improved visual function and VRQOL. Despite improvements, this study showed no difference postoperatively whether air or BSS tamponade was used during surgery. As a result, air tamponade may not be a mandatory treatment for IEM surgery and provides no additional advantage compared with BSS tamponade.
Published: 2023
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26. Chemotherapy-Induced Peripheral Neuropathy (CIPN) in Patients Receiving 4-6 Cycles of Platinum-Based and Taxane-Based Chemotherapy: A Prospective, Single-Center Study from Kosovo.

Author: Myftiu B, Hundozi Z, Sermaxhaj F, Blyta A, Shala N, Jashari F, Qorraj Bytyqi H, Hyseni E, and Kurtishi I
Subjects: Bridged-Ring Compounds, Humans, Kosovo, Platinum adverse effects, Platinum Compounds adverse effects, Prospective Studies, Taxoids adverse effects, Antineoplastic Agents adverse effects, Peripheral Nervous System Diseases chemically induced, Peripheral Nervous System Diseases drug therapy
Abstract: BACKGROUND Chemotherapy-induced peripheral neuropathy (CIPN) is most commonly associated with platinum-based drugs, taxanes, and vinca alkaloids. This prospective study from a single center in Kosovo aimed to evaluate CIPN in 120 patients receiving 4-6 cycles of platinum-based and taxane-based chemotherapy. MATERIAL AND METHODS One hundred twenty patients underwent neurological examination and nerve conduction studies (NCS) before chemotherapy, and after 4 to 6 cycles of treatment. Sixty patients were treated with platinum-based chemotherapy, 30 were treated with taxane-based chemotherapy, and 22 patients received a combination of platinum- and taxane-based chemotherapy. The most commonly used platinum-based compounds were oxaliplatin and carboplatin, whereas the most commonly used taxane medications were paclitaxel and docetaxel. Presence of neuropathy was confirmed with neurological examination of electrophysiological criteria applicable for polyneuropathies. Total Neuropathy Score (TNSr) was used to combine clinical and electrophysiological values. RESULTS Around 90% of patients self-reported neuropathic symptoms, and in 60% of them polyneuropathy was present in NCS. All sensory and motor nerves had significantly lower amplitudes (P<0.01). Platinum-based agents caused more pronounced decrease in ulnar nerve compound motor action potential (CMAP) (P<0.05); when used solely or in combination with taxanes, they caused significant decrease in tibial nerve CMAP (P<0.01). TNSr did not reach statistical significance between groups; only clinical muscle strength showed pronounced weakness in the combined protocol (P<0.05). CONCLUSIONS These findings support previous studies and show that CIPN, including sensory and motor symptoms, is commonly associated with chemotherapy. Platinum-based chemotherapy agents were more commonly associated with ulnar and tibial nerve damage in this study population.
Published: 2022
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27. A 14-Year-Old Male Patient with Kawasaki Disease Presented with Stroke after COVID-19.

Author: Shala N, Jashari F, Boshnjaku D, Shala A, Ibrahimi P, Kukaj V, and Dreshaj S
Abstract: According to several studies, children represent only about 2% of the patients affected by the current SARS-CoV-2, and most often, they are asymptomatic. However, there is a concern about a vascular inflammatory disease which is similar to Kawasaki disease observed in children and adolescents weeks after infection. We report a case of Kawasaki disease presented with ischemic stroke in a 14-year-old male patient following SARS-Cov-2 infection., Competing Interests: The authors declare no conflicts of interest., (Copyright © 2021 Nexhmedin Shala et al.)
Published: 2021
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28. Divergent immunohistochemical expression of CD21 and CD23 by follicular dendritic cells with increasing grade of follicular lymphoma.

Author: Kurshumliu F, Sadiku-Zehri F, Qerimi A, Vela Z, Jashari F, Bytyci S, Rashiti V, and Sadiku S
Subjects: Adult, Aged, Cyclin A analysis, Cyclin A metabolism, Disease Progression, Female, Humans, Immunohistochemistry, Ki-67 Antigen analysis, Ki-67 Antigen metabolism, Lectins, C-Type metabolism, Lymph Nodes cytology, Male, Middle Aged, Neoplasm Grading, Prognosis, Receptors, Complement 3d metabolism, Receptors, IgE metabolism, Dendritic Cells, Follicular pathology, Lectins, C-Type analysis, Lymph Nodes pathology, Lymphoma, Follicular pathology, Receptors, Complement 3d analysis, Receptors, IgE analysis
Abstract: Background: Ultrastructural and immunohistochemical differences have been described in FDCs of primary and secondary follicles, illustrating the highly compartmentalized structure of lymph follicles. Differences in FDC immunophenotype in different grades of FL may reflect some parallelism between reactive and neoplastic conditions in terms of FDC-B cell interaction and may be used as a valuable additional tool for grading FL., Methods: A total of 60 paraffin blocks from patients with follicular lymphoma, 30 cases each of grade 1 and 3, were retrieved from our archive. Immunohistochemical analysis was carried out for CD21, CD23, cyclin A, and Ki-67., Results: Our study demonstrates that during evaluation, six patterns of FDC distribution were distinguished. The intensity of stain for CD21 was not statistically significant in grade 1 and grade 3 FL (p = 0.340). In contrast, grade 3 FLs exhibited a significant decrease of CD23 expression by the FDCs (p < 0.001). By CD21 stain, there was no significant difference in the distribution of pattern 1 in grades 1 and 3 (p = 0.098). In contrast, in grade 3, this pattern was significantly less observed by CD23 stain (p = 0.016). The same was observed for pattern 2 for CD21 (p = 0.940) and CD23 (p = 0.010) and pattern 4 for CD21 (p = 0.305) and CD23 (p = 0.005), respectively. Distribution of pattern 5 was significantly different between grades 1 and 3 both for CD21 (p = 0.005) and CD23 (p < 0.001). Distribution of patterns 2 and 6 was not significantly different between grades 1 and 3 for CD21 and CD23. The values of cyclin A and Mib-1 were also significantly different between grades 1 and 3 (p < 0.001)., Conclusions: The observed patterns of FDCs lead us to believe that similar to reactive lymph node follicles, neoplastic follicles in FL, at least in early stages, have an organized structure. Hypothetically, with CD21, CD23, and cyclin A immunohistochemistry, the sequence of events in FL progression may be traced.
Published: 2019
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29. Complete revascularization for patients with ST-segment elevation myocardial infarction and multivessel coronary artery disease: a meta-analysis of randomized trials.

Author: Bajraktari G, Jashari H, Ibrahimi P, Alfonso F, Jashari F, Ndrepepa G, Elezi S, and Henein MY
Subjects: Humans, Randomized Controlled Trials as Topic, Treatment Outcome, Coronary Vessels pathology, Coronary Vessels physiopathology, Myocardial Revascularization adverse effects, Myocardial Revascularization methods, Percutaneous Coronary Intervention adverse effects, Percutaneous Coronary Intervention methods, ST Elevation Myocardial Infarction diagnosis, ST Elevation Myocardial Infarction surgery
Abstract: Introduction: Despite the recent findings in randomized clinical trials (RCTs) with limited sample sizes and the updates in clinical guidelines, the current available data for the complete revascularization (CR) in hemodynamically stable patients with ST-segment elevation myocardial infarction (STEMI) at the time of primary percutaneous coronary intervention (PCI) are still contradictory., Aim: The aim of this meta-analysis of the existing RCTs was to assess the efficacy of the CR versus revascularization of infarct-related artery (IRA) only during primary PCI in patients with STEMI and multivessel disease (MVD)., Patients and Methods: We searched PubMed, MEDLINE, Embase, Scopus, Google Scholar, Cochrane Central Register of Controlled Trials (CENTRAL), and ClinicalTrials.gov databases aiming to find RCTs for patients with STEMI and MVD which compared CR with IRA-only. Random effect risk ratios (RRs) were calculated for efficacy and safety outcomes., Results: Ten RCTs with 3291 patients were included. The median follow-up duration was 17.5 months. Major adverse cardiac events (RR=0.57; 0.43-0.76; P<0.0001), cardiac mortality (RR=0.52; 0.31-0.87; P=0.014), and repeat revascularization (RR=0.50; 0.30-0.84; P=0.009) were lower in CR compared with IRA-only strategies. However, there was no significant difference in the risk of all-cause mortality, recurrent nonfatal myocardial infarction, stroke, major bleeding events, and contrast-induced nephropathy., Conclusion: For patients with STEMI and MVD undergoing primary PCI, the current evidence suggests that the risk of major adverse cardiac events, repeat revascularization, and cardiac death is reduced by CR. However, the risk for all-cause mortality and PCI-related complications is not different from the isolated culprit lesion-only treatment. Although these findings support the cardiac mortality and safety benefit of CR in stable STEMI, further large trials are required to provide better guidance for optimum management of such patients.
Published: 2018
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30. Carotid IM-GSM is better than IMT for identifying patients with multiple arterial disease.

Author: Jashari F, Ibrahimi P, Johansson E, Grönlund C, Wester P, and Henein MY
Subjects: Aged, Asymptomatic Diseases, Female, Humans, Male, Middle Aged, Observer Variation, Predictive Value of Tests, Reproducibility of Results, Retrospective Studies, Severity of Illness Index, Atherosclerosis diagnostic imaging, Carotid Artery, Common diagnostic imaging, Carotid Intima-Media Thickness, Carotid Stenosis diagnostic imaging, Coronary Artery Disease diagnostic imaging, Peripheral Arterial Disease diagnostic imaging, Ultrasonography, Doppler
Abstract: Objective: Atherosclerosis is a systemic inflammatory disease that can affect more than one arterial bed simultaneously. The aim of this study was to determine the relationship between ultrasound markers of atherosclerosis and multiple arterial disease., Design: We have included 87 currently asymptomatic carotid disease patients (mean age 69 ± 6 year, 34% females) in this study. Intima media thickness (IMT) and intima media-grey scale median (IM-GSM) were measured in the common carotid artery (CCA), and correlated with previous and/or current atherosclerotic vascular disease in the coronary, carotid and lower extremities. Patients were divided into three groups: (1) asymptomatic, (2) previous symptoms in one arterial territory and (3) previous symptoms in multiple arterial territories., Results: Patients with previous disease in the coronary arteries had higher IMT (p = .034) and lower IM-GSM (p < .001), and those with prior stroke had lower IM-GSM (p = .007). Neither IMT nor IM-GSM was different between patients with and without previous lower extremity vascular disease. IM-GSM was significantly different between groups, it decreased significantly with increasing number of arterial territories affected (37.7 ± 15.4 vs. 29.3 ± 16.4 vs. 20.7 ± 12.9) p < .001, for asymptomatic, symptoms in one and in multiple arterial systems, respectively. Conventional IMT was not significantly different between groups p = .49., Conclusion: Carotid IMT was higher and IM-GSM lower in patients with symptomatic nearby arterial territories but not in those with peripheral disease. In contrast to conventional IMT, IM-GSM can differentiate between numbers of arterial territories affected by atherosclerosis, suggesting that it is a better surrogate for monitoring multiple arterial territory disease.
Published: 2018
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31. Individualizing Treatment Approaches for Epileptic Patients with Glucose Transporter Type1 (GLUT-1) Deficiency.

Author: Daci A, Bozalija A, Jashari F, and Krasniqi S
Subjects: Anticonvulsants therapeutic use, Epilepsy diagnosis, Epilepsy genetics, Glucose Transporter Type 1 deficiency, Humans, Pharmacogenetics methods, Epilepsy drug therapy, Genetic Testing methods, Glucose Transporter Type 1 genetics, Precision Medicine methods
Abstract: Monogenic and polygenic mutations are important contributors in patients suffering from epilepsy, including metabolic epilepsies which are inborn errors of metabolism with a good respond to specific dietetic treatments. Heterozygous variation in solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1) and mutations of the GLUT1/SLC2A2 gene results in the failure of glucose transport, which is related with a glucose type-1 transporter (GLUT1) deficiency syndrome (GLUT1DS). GLUT1 deficiency syndrome is a treatable disorder of glucose transport into the brain caused by a variety of mutations in the SLC2A1 gene which are the cause of different neurological disorders also with different types of epilepsy and related clinical phenotypes. Since patients continue to experience seizures due to a pharmacoresistance, an early clinical diagnosis associated with specific genetic testing in SLC2A1 pathogenic variants in clinical phenotypes could predict pure drug response and might improve safety and efficacy of treatment with the initiation of an alternative energy source including ketogenic or analog diets in such patients providing individualized strategy approaches., Competing Interests: The authors declare no conflict of interest.
Published: 2018
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32. Influence of apelin-12 on troponin levels and the rate of MACE in STEMI patients.

Author: Krasniqi X, Berisha B, Gashi M, Koçinaj D, Jashari F, and Vincelj J
Subjects: Aged, Area Under Curve, Biomarkers blood, Electrocardiography, Female, Humans, Kaplan-Meier Estimate, Kosovo, Male, Middle Aged, Myocardial Reperfusion, Predictive Value of Tests, Prospective Studies, ROC Curve, Risk Factors, ST Elevation Myocardial Infarction diagnosis, ST Elevation Myocardial Infarction mortality, ST Elevation Myocardial Infarction therapy, Time Factors, Treatment Outcome, Apelin blood, Intercellular Signaling Peptides and Proteins blood, ST Elevation Myocardial Infarction blood, Troponin I blood
Abstract: Background: During acute myocardial infarction, phosphorylated TnI levels, Ca 2+ sensitivity and ATPase activity are decreased in the myocardium, and the subsequent elevation in Ca 2+ levels activates protease I (caplain I), leading to the proteolytic degradation of troponins. Concurrently, the levels of apelin and APJ expression are increased by limiting myocardial injury., Methods: In this prospective observational study, 100 consecutive patients with ST-elevation acute myocardial infarction were included. Patients meeting the following criteria were included in our study: (1) continuous chest pain lasting for >30 min, (2) observation of ST-segment elevation of more than 2 mm in two adjacent leads by electrocardiography (ECG), (3) increased cardiac troponin I levels, and (4) patients who underwent reperfusion therapy. We evaluated the levels of apelin-12 and troponin I on the first and seventh days after reperfusion therapy in all patients., Results: Apelin-12 was inversely correlated with troponin I levels (Spearman's correlation = -0.40) with a p value <0.001. There was variability in the apelin values on the seventh day (Kruskal-Wallis test) based on major adverse cardiac events (MACE) (p = 0.012). Using ROC curve analyses, a cut-off value of >2.2 for the association of apelin with MACE was determined, and the AUC was 0.71 (95% CI, 0.58-0.84). Survival analysis using the Kaplan-Meier method showed a lower rate of MACE among patients with apelin levels >2.2 (p = 0.002), and the ROC curve analysis showed a statistically significant difference in the area under the curve (p = 0.004)., Conclusion: The influence of apelin levels on troponin levels in the acute phase of STEMI is inversely correlated, whereas in the non-acute phase, low apelin values were associated with a high rate of MACE.
Published: 2017
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33. Accuracy of Conventional Diagnostic Methods for Identifying Structural Changes in Patients with Focal Epilepsy.

Author: Dakaj N, Kruja J, Jashari F, Boshnjaku D, Shatri N, and Zeqiraj K
Abstract: Background: Epilepsy is a neurological disorder characterized by abnormal firing of nerve impulses in the brain., Aim: This study aims to investigate the frequency of appearance of pathological changes in conventional examination methods (electroencephalography-EEG, brain computerized tomography -CT or brain magnetic resonance imaging - MRI) in patients with epilepsy, and relationship between clinical manifestations and localization of changes in CT or MRI., Methods: In this study we have included 110 patients with focal epilepsy who fulfilled the inclusion criteria out of 557 initially diagnosed patients. Detailed clinical examination together with brain imaging (CT and MRI) and electroencephalography examination was performed. We have evaluated the accuracy of each diagnostic method to localize the epileptic focus. Diagnosis of epilepsy was determined by the ILAE (International League Against Epilepsy) criteria of the year 1989, and classification of epileptic seizures was made according to the ILAE classification 2010., Results: Electroencephalography presented changes in 60.9% of patients; brain CT in 42.1%, and MRI in 78% of the patients. The results of our study showed that clinical manifestations were not always conveyed with pathological changes in conventional examining methods performed. Of the total of 79 patients with changes in imaging (8 with changes in CT and 71 in MRI), 79.7% presented a clinical picture compatible with the region in which morphological changes were found, while in 20.3% of patients the presented morphological changes were not aligned with the clinical picture., Conclusion: In patients with epilepsy, conventional examination methods do not always find pathological changes, while clinical manifestations of epilepsy did not always coincide with the location of changes in imaging. Further studies are needed to see if there is clear border between focal and generalized epilepsy., Competing Interests: • Conflict of interest: none declared.
Published: 2016
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34. Comparison of drug-eluting balloon versus drug-eluting stent treatment of drug-eluting stent in-stent restenosis: A meta-analysis of available evidence.

Author: Bajraktari G, Jashari H, Ibrahimi P, Alfonso F, Jashari F, Ndrepepa G, Elezi S, and Henein MY
Subjects: Angioplasty, Balloon, Coronary mortality, Humans, Observational Studies as Topic, Percutaneous Coronary Intervention adverse effects, Percutaneous Coronary Intervention mortality, Prosthesis Design, Prosthesis Failure, Randomized Controlled Trials as Topic, Time Factors, Treatment Outcome, Angioplasty, Balloon, Coronary instrumentation, Coronary Artery Disease therapy, Coronary Restenosis etiology, Drug-Eluting Stents adverse effects, Percutaneous Coronary Intervention instrumentation
Abstract: Background: In-stent restenosis (ISR) remains an important concern despite the recent advances in the drug-eluting stent (DES) technology. The introduction of drug-eluting balloons (DEB) offers a good solution to such problem., Objectives: We performed a meta-analysis to assess the clinical efficiency and safety of DEB compared with DES in patients with DES-ISR., Methods: A systematic search was conducted and all randomized and observational studies which compared DEB with DES in patients with DES-ISR were included. The primary outcome measure-major adverse cardiovascular events (MACE)-as well as individual events as target lesion revascularization (TLR), stent thrombosis (ST), myocardial infarction (MI), cardiac death (CD) and all-cause mortality, were analyzed., Results: Three randomized and 4 observational studies were included with a total of 2052 patients. MACE (relative risk [RR]=1.00, 95% confidence interval (CI) 0.68 to 1.46, P=0.99), TLR (RR=1.15 [CI 0.79 to 1.68], P=0.44), ST (RR=0.37[0.10 to 1.34], P=0.13), MI (RR=0.97 [0.49 to 1.91], P=0.93) and CD (RR=0.73 [0.22 to 2.45], P=0.61) were not different between patients treated with DEB and with DES. However, all-cause mortality was lower in patients treated with DEB (RR=0.45 [0.23 to 0.87, P=0.019) and in particular when compared to only first generation DES (RR 0.33 [0.15-0.74], P=0.007). There was no statistical evidence for publication bias., Conclusions: The results of this meta-analysis showed that DEB and DES have similar efficacy and safety for the treatment of DES-ISR., (Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.)
Published: 2016
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35. Hypertension on admission is associated with a lower risk of early seizures after stroke.

Author: Hundozi Z, Shala A, Boshnjaku D, Bytyqi S, Rrustemi J, Rama M, and Jashari F
Subjects: Age Factors, Aged, Aged, 80 and over, Chi-Square Distribution, Female, Humans, Hypertension diagnostic imaging, Logistic Models, Male, Middle Aged, Neuroimaging, Retrospective Studies, Risk Factors, Seizures diagnostic imaging, Seizures epidemiology, Stroke classification, Stroke diagnostic imaging, Stroke epidemiology, Blood Pressure physiology, Hypertension complications, Seizures etiology, Stroke complications
Abstract: Purpose: Despite the common occurrence of early seizures (ES) after stroke, the relationship between risk factors and this complication of stroke is not well established. In this study we have examined the relationship between clinical measures on admission and ES after stroke., Methods: We included 1073 patients (mean age 69 ± 12, 51.6% females) with ischemic and haemorrhagic stroke. The frequency of seizure occurrence within 2 weeks of stroke was determined. We used a logistic regression model to analyse the effect of blood pressure on admission and other clinical factors (age, gender, diabetes, atrial fibrillation and dyslipidemia) on the occurrence of ES after stroke., Results: ES occurred after 4.1% and 4.0% of ischemic and haemorrhagic strokes respectively. Compared to patients with high blood pressure on admission, those with low and normal blood pressure had a higher risk of ES after stroke (2.9% vs.7.5% vs. 7.6%, p=0.001). Also the mean age of patients with post-stroke ES was lower (62.5 vs. 69.3, p<0.001). In a logistic regression analysis, low/normal blood pressure remained independently associated with ES after stroke with OR of 2.46 (95% CI 1.38-4.63, p=0.006)., Conclusion: ES after stroke was equally frequent in patients with ischemic and haemorrhagic stroke. Low/normal blood pressure on admission and younger patient age were risk factors for ES after stroke., (Copyright © 2016 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.)
Published: 2016
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36. Common carotid intima-media features determine distal disease phenotype and vulnerability in asymptomatic patients.

Author: Ibrahimi P, Jashari F, Johansson E, Grönlund C, Bajraktari G, Wester P, and Henein MY
Subjects: Aged, Atherosclerosis diagnostic imaging, Carotid Artery Diseases diagnosis, Carotid Artery, Common diagnostic imaging, Female, Humans, Male, Middle Aged, Phenotype, Plaque, Atherosclerotic diagnosis, Carotid Artery Diseases complications, Carotid Intima-Media Thickness, Plaque, Atherosclerotic complications
Abstract: Objectives: There is a growing awareness of the importance of carotid plaque features evaluation in stroke prediction. Carotid intima-media thickness (IMT) and recently its echogenicity were used for stroke prediction, although their clinical relevance was not well determined. The aim of this study was to assess the relationship between common carotid artery (CCA) ultrasound markers of atherosclerosis and distal, bifurcation and internal carotid artery (ICA), plaque features., Methods: We analyzed 137 carotid arteries in 87 asymptomatic patients with known carotid disease (mean age 69 ± 6 year, 34.5% females). Intima media thickness (IMT) and its gray scale median (IM-GSM) were measured at the CCA. Plaque textural features including gray scale median (GSM), juxtaluminal black area (JBA-mm(2)) without a visible cap, and plaque coarseness, at bifurcation and ICA were also determined. CCA measurements were correlated with those of the distal plaques., Results: An increased IMT in CCA correlated with plaque irregularities in the bifurcation and ICA (r=0.53, p<0.001), while IM-GSM was closely related to plaque echogenicity (GSM) (r=0.76, p<0.001), and other textural plaque features. Both, IMT and IM-GSM correlated weakly with stenosis severity (r=0.27, p=0.001 and r=-0.18, p=0.026) respectively., Conclusion: In asymptomatic patients, measurements of CCA reflect distal, bifurcation and ICA disease, with IMT reflecting plaque irregularities and IM-GSM as markers of textural plaque abnormalities. Integrating measurements of both IMT and IM-GSM in a model could be used as a better marker of disease vulnerability over and above each measure individually., (Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.)
Published: 2015
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37. Atherosclerotic Calcification Detection: A Comparative Study of Carotid Ultrasound and Cone Beam CT.

Author: Jashari F, Ibrahimi P, Johansson E, Ahlqvist J, Arnerlöv C, Garoff M, Jäghagen EL, Wester P, and Henein MY
Subjects: Aged, Carotid Arteries pathology, Female, Humans, Male, Middle Aged, Sensitivity and Specificity, Ultrasonography, Carotid Arteries diagnostic imaging, Carotid Artery Diseases diagnosis, Cone-Beam Computed Tomography methods
Abstract: Background and Aim: Arterial calcification is often detected on ultrasound examination but its diagnostic accuracy is not well validated. The aim of this study was to determine the accuracy of carotid ultrasound B mode findings in detecting atherosclerotic calcification quantified by cone beam computed tomography (CBCT)., Methods: We analyzed 94 carotid arteries, from 88 patients (mean age 70 ± 7 years, 33% females), who underwent pre-endarterectomy ultrasound examination. Plaques with high echogenic nodules and posterior shadowing were considered calcified. After surgery, the excised plaques were examined using CBCT, from which the calcification volume (mm3) was calculated. In cases with multiple calcifications the largest calcification nodule volume was used to represent the plaque. Carotid artery calcification by the two imaging techniques was compared using conventional correlations., Results: Carotid ultrasound was highly accurate in detecting the presence of calcification; with a sensitivity of 88.2%. Based on the quartile ranges of calcification volumes measured by CBCT we have divided plaque calcification into four groups: <8; 8-35; 36-70 and >70 mm3. Calcification volumes ≥8 were accurately detectable by ultrasound with a sensitivity of 96%. Of the 21 plaques with <8 mm3 calcification volume; only 13 were detected by ultrasound; resulting in a sensitivity of 62%. There was no difference in the volume of calcification between symptomatic and asymptomatic patients., Conclusion: Carotid ultrasound is highly accurate in detecting the presence of calcified atherosclerotic lesions of volume ≥8 mm3; but less accurate in detecting smaller volume calcified plaques. Further development of ultrasound techniques should allow better detection of early arterial calcification.
Published: 2015
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38. Normal ranges of left ventricular strain in children: a meta-analysis.

Author: Jashari H, Rydberg A, Ibrahimi P, Bajraktari G, Kryeziu L, Jashari F, and Henein MY
Subjects: Adolescent, Child, Child, Preschool, Elastic Modulus physiology, Female, Humans, Infant, Infant, Newborn, Male, Reference Values, Reproducibility of Results, Sensitivity and Specificity, Stress, Mechanical, Stroke Volume physiology, Young Adult, Aging physiology, Echocardiography methods, Heart Ventricles diagnostic imaging, Ventricular Function, Left physiology
Abstract: Aims: The definition of normal values of two-dimensional speckle-tracking echocardiography derived left ventricular (LV) deformation parameters, is of critical importance for the routine application of this modality in children. The objectives of this study were to perform a meta-analysis of normal ranges for longitudinal, circumferential and radial strain/strain rate values and to identify confounders that may contribute to differences in reported measures., Methods and Results: A systematic search was conducted. Studies describing normal healthy subjects and observational studies that used control groups as a comparison were included. Data were combined using a random-effect model. Effects of demographic, clinical and equipment variables were assessed through meta-regression. The search identified 1,192 subjects form 28 articles. Longitudinal strain (LS) normal mean values varied from -12.9 to -26.5 (mean, -20.5; 95% CI, -20.0 to -21.0). Normal mean values of circumferential strain (CS) varied from -10.5 to -27.0 (mean, -22.06; 95% CI, -21.5 to -22.5). Radial strain (RS) normal mean values varied from 24.9 to 62.1 (mean, 45.4; 95% CI, 43.0 to 47.8). Meta-regression showed LV end diastolic diameter as a significant determinant of variation for LS. Longitudinal systolic strain rate (LSRs) was significantly determined by the age and RS by the type of vendor used., Conclusion: Variations among different normal ranges were dependent on the vendor used, LV end-diastolic diameter and age. Vendor-independent software for analyzing myocardial deformation in children, using images from different vendors would be the ideal solution for strain measurements or else using the same system for patient's follow up.
Published: 2015
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39. Ultrasound assessment of carotid plaque echogenicity response to statin therapy: a systematic review and meta-analysis.

Author: Ibrahimi P, Jashari F, Bajraktari G, Wester P, and Henein MY
Subjects: Carotid Stenosis complications, Humans, Hypercholesterolemia complications, Hypercholesterolemia drug therapy, Publication Bias, Regression Analysis, Ultrasonography, Carotid Stenosis diagnostic imaging, Carotid Stenosis drug therapy, Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use, Ultrasonics
Abstract: Objective: To evaluate in a systematic review and meta-analysis model the effect of statin therapy on carotid plaque echogenicity assessed by ultrasound., Methods: We have systematically searched electronic databases (PubMed, MEDLINE, EMBASE and Cochrane Center Register) up to April, 2015, for studies evaluating the effect of statins on plaque echogenicity. Two researchers independently determined the eligibility of studies evaluating the effect of statin therapy on carotid plaque echogenicity that used ultrasound and grey scale median (GSM) or integrated back scatter (IBS)., Results: Nine out of 580 identified studies including 566 patients' carotid artery data were meta-analyzed for a mean follow up of 7.2 months. A consistent increase in the echogenicity of carotid artery plaques, after statin therapy, was reported. Pooled weighted mean difference % (WMD) on plaque echogenicity after statin therapy was 29% (95% CI 22%-36%), p<0.001, I2=92.1%. In a meta-regression analysis using % mean changes of LDL, HDL and hsCRP as moderators, it was shown that the effects of statins on plaque echogenicity were related to changes in hsCRP, but not to LDL and HDL changes from the baseline. The effect of statins on the plaque was progressive; it showed significance after the first month of treatment, and the echogenicity continued to increase in the following six and 12 months., Conclusions: Statin therapy is associated with a favorable increase of carotid plaque echogenicity. This effect seems to be dependent on the period of treatment and hsCRP change from the baseline, independent of changes in LDL and HDL.
Published: 2015
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40. Hypoglycemia-induced hemiparesis in a diabetic woman after childbirth.

Author: Kukaj V, Jashari F, Boshnjaku D, Istrefi E, and Ibrahimi P
Abstract: A 24-year-old female with type 1 diabetes mellitus presented with hemiparesis induced by hypoglycemia. She was hospitalized because she has noticed a weakness of her right hand and leg three days after childbirth. On physical examination she had an expressive dysphasia and right side hemiparesis with facial drop. Hypoglycemia is rarely associated with hemiparesis and it is often overlooked, especially when it happens in patients at higher risk of other diseases frequently associated with hemiparesis. Although sporadical cases of hypoglycemia-induced hemiparesis were reported, the clear pathophysiology behind this is not well determined. However, any individual case is important in order to increase the awareness of hypoglycemia as an important etiology of this condition.
Published: 2015
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41. Combined electrical and global markers of dyssynchrony predict clinical response to cardiac resynchronization therapy.

Author: Bajraktari G, Rönn F, Ibrahimi P, Jashari F, Lindmark K, Jensen SM, and Henein MY
Subjects: Aged, Atrial Fibrillation epidemiology, Comorbidity, Female, Heart Failure diagnostic imaging, Heart Failure drug therapy, Heart Failure epidemiology, Heart Failure physiopathology, Humans, Male, Middle Aged, Natriuretic Peptide, Brain blood, Peptide Fragments blood, ROC Curve, Treatment Outcome, Ultrasonography, Doppler, Ventricular Dysfunction, Left, Cardiac Resynchronization Therapy, Heart Failure therapy
Abstract: Aim: To assess potential additional value of global left ventricular (LV) dyssynchrony markers in predicting cardiac resynchronization therapy (CRT) response in heart failure (HF) patients., Methods: We included 103 HF patients (mean age 67 ± 12 years, 83% male) who fulfilled the guidelines criteria for CRT treatment. All patients had undergone full clinical assessment, NT-proBNP and echocardiographic examination. Global LV dyssynchrony was assessed using total isovolumic time (t-IVT) and Tei index. On the basis of reduction in the NYHA class after CRT, patients were divided into responders and non-responders., Results: Prolonged t-IVT [0.878 (range, 0.802-0.962), p = 0.005], long QRS duration [0.978 (range, 0.960-0.996), p = 0.02] and high tricuspid regurgitation pressure drop [1.047 (range, 1.001-1.096), p = 0.046] independently predicted response to CRT. A t-IVT ≥ 11.6 s/min was 67% sensitive and 62% specific (AUC 0.69, p = 0.001) in predicting CRT response. Respective values for a QRS ≥ 151 ms were 66% and 62% (AUC 0.65, p = 0.01). Combining the two variables had higher specificity (88%) in predicting CRT response. In atrial fibrillation (AF) patients, only prolonged t-IVT [0.690 (range, 0.509-0.937), p = 0.03] independently predicted CRT response., Conclusion: Combining prolonged t-IVT and the conventionally used broad QRS duration has a significantly higher specificity in identifying patients likely to respond to CRT. Moreover, in AF patients, only prolonged t-IVT independently predicted CRT response.
Published: 2014
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42. Vulnerable plaques in the contralateral carotid arteries in symptomatic patients: a detailed ultrasound analysis.

Author: Ibrahimi P, Jashari F, Johansson E, Gronlund C, Bajraktari G, Wester P, and Henein MY
Subjects: Aged, Carotid Artery Diseases pathology, Carotid Stenosis pathology, Female, Humans, Male, Middle Aged, Plaque, Atherosclerotic pathology, Ultrasonography, Carotid Arteries pathology, Carotid Artery Diseases diagnostic imaging, Carotid Stenosis complications, Plaque, Atherosclerotic diagnostic imaging
Abstract: Background and Aim: Carotid plaques may represent a generalized atherosclerotic syndrome or a localized disease. The aim of this study was to assess the morphological and textural features of carotid plaques located contralateral to the symptomatic side and compare them with the symptomatic side and with plaques from asymptomatic patients., Methods: We studied 66 arteries in 39 patients (mean age 70 ± 7 year, 33% females). Arterial plaques were classified as either symptomatic (n = 30), contralateral to symptomatic (n = 25) or asymptomatic (n = 11). We compared several plaque features between these groups including the mean values of the grey scale median (GSM), entropy, juxtaluminal black area (JBA) without visible echogenic cap, GSM of the JBA and surface irregularity., Results: The plaques contralateral to symptomatic arteries had similar morphological and textural features to those in the symptomatic arteries. In contrast, they had more vulnerable morphological and textural features than those in asymptomatic arteries: less smooth plaques (12% vs. 55%) and instead more often mildly irregular (60% vs 36%) or markedly irregular (28% vs. 9%; p = 0.03), lower GSM (26.2 ± 8 vs. 49.4 ± 14, p < 0.001) and lower GSM of the JBA (5.0 ± 3.6 vs. 11.4 ± 2.1, p = 0.008). The frequency of entropy and plaque calcification was similar in all groups., Conclusion: Symptomatic patients with carotid artery disease seem to have similar morphological and textural features of vulnerability in the symptomatic and the contralateral carotid arteries, which are profound compared with asymptomatic carotid arteries. These findings support the concept of generalized carotid atherosclerotic pathology rather than incidental unilateral disease, and also emphasize a need for aggressive measures for plaque stabilization, particularly in symptomatic patients., (Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.)
Published: 2014
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43. Coronary and carotid atherosclerosis: how useful is the imaging?

Author: Ibrahimi P, Jashari F, Nicoll R, Bajraktari G, Wester P, and Henein MY
Subjects: Angiography, Calcinosis pathology, Calcium metabolism, Carotid Artery Diseases diagnostic imaging, Carotid Artery Diseases pathology, Coronary Artery Disease diagnostic imaging, Coronary Artery Disease pathology, Coronary Vessels pathology, Humans, Inflammation, Magnetic Resonance Imaging, Neovascularization, Pathologic, Plaque, Atherosclerotic pathology, Risk, Tomography, X-Ray Computed, Ultrasonography, Carotid Artery Diseases blood, Coronary Artery Disease blood
Abstract: The recent advancement of imaging modalities has made possible visualization of atherosclerosis disease in all phases of its development. Markers of subclinical atherosclerosis or even the most advanced plaque features are acquired by invasive (IVUS, OCT) and non-invasive imaging modalities (US, MRI, CTA). Determining plaques prone to rupture (vulnerable plaques) might help to identify patients at risk for myocardial infarction or stroke. The most accepted features of plaque vulnerability include: thin cap fibroatheroma, large lipid core, intimal spotty calcification, positive remodeling and intraplaque neovascularizations. Today, research is focusing on finding imaging techniques that are less invasive, less radiation and can detect most of the vulnerable plaque features. While, carotid atherosclerosis can be visualized using noninvasive imaging, such as US, MRI and CT, imaging plaque feature in coronary arteries needs invasive imaging modalities. However, atherosclerosis is a systemic disease with plaque development simultaneously in different arteries and data acquisition in carotid arteries can add useful information for prediction of coronary events., (Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.)
Published: 2013
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44. Abnormal systolic and diastolic myocardial function in obese asymptomatic adolescents.

Author: Batalli-Këpuska A, Bajraktari G, Zejnullahu M, Azemi M, Shala M, Batalli A, Ibrahimi P, Jashari F, and Henein MY
Subjects: Adolescent, Body Mass Index, Child, Diastole, Echocardiography, Female, Follow-Up Studies, Heart Ventricles diagnostic imaging, Humans, Male, Obesity complications, Obesity diagnostic imaging, Prognosis, Retrospective Studies, Stroke Volume, Systole, Ventricular Dysfunction diagnostic imaging, Ventricular Dysfunction etiology, Heart Ventricles physiopathology, Myocardial Contraction physiology, Obesity physiopathology, Ventricular Dysfunction physiopathology, Ventricular Function, Left physiology
Abstract: Structural and functional cardiac changes are known in obese adults. We aimed to assess the relationship between body mass index (BMI) and cardiac function in overweight and obese asymptomatic adolescents. Ninety three healthy adolescents, aged 12.6 ± 1.2 years, received weight, height, BMI, waist, hips, waist/hips ratio assessment, hematology and biochemistry tests and an echocardiogram. Based on BMI, subjects were divided into: lean (L, n=32), overweight (Ov, n=33) and obese (Ob, n=32). Interventricular septal and LV posterior wall thickness were increased parallel to the BMI (L: 0.84 ± 0.1cm, Ov: 0.88 ± 0.1cm, Ob: 0.96 ± 0.1cm, p<0.001, and L: 0.78 ± 0.1cm, Ov: 0.8 ± 0.1cm, Ob: 0.94 ± 0.1cm, p<0.001, respectively) as were relative wall thickness (RWT) and mass index (LVMI) (L: 0.34 ± 0.05, Ov: 0.34 ± 0.05, Ob: 0.40 ± 0.04, p<0.001, and L: 47.7 ± 8.4 g/m(2), Ov: 51.9 ± 8.3g/m(2), Ob: 65.2 ± 13.3g/m(2), p=0<001, respectively). LV early diastolic (E') lateral and septal velocities (L: 15.3 ± 3.9 cm/s, Ov: 13.6 ± 4 cm/s, Ob: 10.5 ± 3.4 cm/s, p<0.001, and L: 12.2 ± 2.3 cm/s, Ov: 11.1 ± 2.4 cm/s, Ob: 9.8 ± 3.1cm/s, p=0.003, respectively), and systolic (S') velocities (L: 9.2 ± 1.4 cm/s, Ov: 9.3 ± 2.3 cm/s, Ob: 8.04 ± 1.5 cm/s, p=0.018, and L: 9.05 ± 2.3 cm/s, Ov: 9 ± 2.4 cm/s, Ob: 7.6 ± 1.1cm/s, p=0.014, respectively) were all reduced, only in obese adolescents. LV lateral E' (r=-0.44, p<0.001) and S' (r=-0.29, p=0.005) correlated with BMI. In asymptomatic adolescents, LV wall is thicker and diastolic function impaired and correlate with BMI. These findings demonstrate early cardiac functional disturbances which might explain the known obesity risk for cardiac disease., (Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.)
Published: 2013
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45. Gender related predictors of limited exercise capacity in heart failure.

Author: Bajraktari G, Kurtishi I, Rexhepaj N, Tafarshiku R, Ibrahimi P, Jashari F, Alihajdari R, Batalli A, Elezi S, and Henein MY
Abstract: Aim: The aim of this study was to investigate the impact of gender on the prediction of limited exercise capacity in heart failure (HF) patients assessed by 6 minute walk test (6-MWT)., Methods: In 147 HF patients (mean age 61 ± 11 years, 50.3% male), a 6-MWT and a Doppler echocardiographic study were performed in the same day. Conventional cardiac measurements were obtained and global LV dyssynchrony was indirectly assessed using total isovolumic time - t-IVT [in s/min; calculated as: 60 - (total ejection time - total filling time)] and Tei index (t-IVT/ejection time). Patients were divided into two groups according to gender, which were again divided into two subgroups based on the 6-MWT distance (Group I: ≤ 300 m, and Group II: > 300 m)., Results: Female patients were younger (p = 0.02), and had higher left ventricular (LV) ejection fraction - EF (p = 0.007) but with similar 6-MWT distance to male patients (p = 68). Group I male patients had lower hemoglobin level (p = 0.02) and lower EF (p = 0.03), compared with Group II, but none of the clinical or echocardiographic variables differed between groups in female patients. In multivariate analysis, only t-IVT [0.699 (0.552-0.886), p = 0.003], and LV EF [0.908 (0.835-0.987), p = 0.02] in males, and NYHA functional class [4.439 (2.213-16.24), p = 0.02] in females independently predicted poor 6-MWT distance (< 300 m)., Conclusion: Despite similar limited exercise capacity, gender determines the pattern of underlying cardiac disturbances; ventricular dysfunction in males and subjective NYHA class in female heart failure patients.
Published: 2013
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46. Coronary calcium score correlates with estimate of total plaque burden.

Author: Bajraktari G, Nicoll R, Ibrahimi P, Jashari F, Schmermund A, and Henein MY
Subjects: Aged, Cohort Studies, Female, Humans, Male, Middle Aged, Plaque, Atherosclerotic diagnostic imaging, Plaque, Atherosclerotic metabolism, Prospective Studies, Calcium metabolism, Coronary Angiography standards, Plaque, Atherosclerotic pathology
Published: 2013
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47. Coronary and carotid atherosclerosis: similarities and differences.

Author: Jashari F, Ibrahimi P, Nicoll R, Bajraktari G, Wester P, and Henein MY
Subjects: Age Factors, Biomarkers, Carotid Artery Diseases epidemiology, Constriction, Pathologic, Coronary Artery Disease epidemiology, Female, Humans, Inflammation, Male, Risk Factors, Sex Factors, Thrombosis physiopathology, Carotid Artery Diseases diagnosis, Carotid Artery Diseases physiopathology, Coronary Artery Disease diagnosis, Coronary Artery Disease physiopathology
Abstract: Although a relationship is commonly accepted between coronary and carotid arterial disease, suggesting that atherosclerosis is a systemic condition, the extent of this association and correspondence has not been fully elucidated. This review discusses recent research in this field and highlights areas for future study. The prevalence of severe carotid stenosis increases with prevalence of coronary stenosis, with the latter being found in a significant number of stroke patients, while those with carotid stenosis may be at higher risk of myocardial infarction than stroke. There also appear to be common risk factors (age, diabetes, hypertension, smoking and dyslipidemia), although the effects in both vascular systems may not be identical. Furthermore, while the degree of stenosis in the coronary artery has little ability to predict acute coronary syndrome, which is caused by local thrombosis from a ruptured or eroded plaque, severe carotid stenosis causing hypoperfusion is highly predictive of stroke, although this effect may be time-limited. This apparent difference in event mechanism in the two arteries is interesting as is the difference in the rate of development of collaterals. Overall, the evidence shows that a clear relationship exists between disease in the coronary and carotid arteries, since conventional risk factors and the extent of stenosis and/or previous events emanating from one artery have a strong bearing on the prevalence of events in the other artery. Nevertheless, the exact correspondence between the two arteries is unclear, with sometimes contradictory study results. More research is needed to identify the full extent of risk factors for severe stenosis and cardio- or cerebral vascular events, among which, inflammatory biomarkers such as hs-CRP and prior vascular events are likely to play a key role., (Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.)
Published: 2013
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