158 results on '"Jarvis, I."'
Search Results
2. A rapid method for determining organic matter maturity using Raman spectroscopy: Application to Carboniferous organic-rich mudstones and coals
- Author
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Henry, D.G., Jarvis, I., Gillmore, G., and Stephenson, M.
- Published
- 2019
- Full Text
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3. Carbon Isotope Stratigraphy
- Author
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Cramer, B.D., primary and Jarvis, I., additional
- Published
- 2020
- Full Text
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4. Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity
- Author
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Meng, B., Abdullahi, A., Ferreira, I. A. T. M., Goonawardane, N., Saito, A., Kimura, I., Yamasoba, D., Gerber, P. P., Fatihi, S., Rathore, S., Zepeda, S. K., Papa, G., Kemp, S. A., Ikeda, T., Toyoda, M., Tan, T. S., Kuramochi, J., Mitsunaga, S., Ueno, T., Shirakawa, K., Takaori-Kondo, A., Brevini, T., Mallery, D. L., Charles, O. J., Baker, S., Dougan, G., Hess, C., Kingston, N., Lehner, P. J., Lyons, P. A., Matheson, N. J., Ouwehand, W. H., Saunders, C., Summers, C., Thaventhiran, J. E. D., Toshner, M., Weekes, M. P., Maxwell, P., Shaw, A., Bucke, A., Calder, J., Canna, L., Domingo, J., Elmer, A., Fuller, S., Harris, J., Hewitt, S., Kennet, J., Jose, S., Kourampa, J., Meadows, A., O'Brien, C., Price, J., Publico, C., Rastall, R., Ribeiro, C., Rowlands, J., Ruffolo, V., Tordesillas, H., Bullman, B., Dunmore, B. J., Graf, S., Hodgson, J., Huang, C., Hunter, K., Jones, E., Legchenko, E., Matara, C., Martin, J., Mescia, F., O'Donnell, C., Pointon, L., Shih, J., Sutcliffe, R., Tilly, T., Treacy, C., Tong, Z., Wood, J., Wylot, M., Betancourt, A., Bower, G., Cossetti, C., De Sa, A., Epping, M., Fawke, S., Gleadall, N., Grenfell, R., Hinch, A., Jackson, S., Jarvis, I., Krishna, B., Nice, F., Omarjee, O., Perera, M., Potts, M., Richoz, N., Romashova, V., Stefanucci, L., Strezlecki, M., Turner, L., De Bie, E. M. D. D., Bunclark, K., Josipovic, M., Mackay, M., Butcher, H., Caputo, D., Chandler, M., Chinnery, P., Clapham-Riley, D., Dewhurst, E., Fernandez, C., Furlong, A., Graves, B., Gray, J., Hein, S., Ivers, T., Le Gresley, E., Linger, R., Kasanicki, M., King, R., Meloy, S., Moulton, A., Muldoon, F., Ovington, N., Papadia, S., Penkett, C. J., Phelan, I., Ranganath, V., Paraschiv, R., Sage, A., Sambrook, J., Scholtes, I., Schon, K., Stark, H., Stirrups, K. E., Townsend, P., Walker, N., Webster, J., Butlertanaka, E. P., Tanaka, Y. L., Ito, J., Uriu, K., Kosugi, Y., Suganami, M., Oide, A., Yokoyama, M., Chiba, M., Motozono, C., Nasser, H., Shimizu, R., Kitazato, K., Hasebe, H., Irie, T., Nakagawa, S., Wu, J., Takahashi, M., Fukuhara, T., Shimizu, K., Tsushima, K., Kubo, H., Kazuma, Y., Nomura, R., Horisawa, Y., Nagata, K., Kawai, Y., Yanagida, Y., Tashiro, Y., Tokunaga, K., Ozono, S., Kawabata, R., Morizako, N., Sadamasu, K., Asakura, H., Nagashima, M., Yoshimura, K., Cardenas, P., Munoz, E., Barragan, V., Marquez, S., Prado-Vivar, B., Becerra-Wong, M., Caravajal, M., Trueba, G., Rojas-Silva, P., Grunauer, M., Gutierrez, B., Guadalupe, J. J., Fernandez-Cadena, J. C., Andrade-Molina, D., Baldeon, M., Pinos, A., Bowen, J. E., Joshi, A., Walls, A. C., Jackson, L., Martin, D., Smith, K. G. C., Bradley, J., Briggs, J. A. G., Choi, J., Madissoon, E., Meyer, K. B., Mlcochova, P., Ceron-Gutierrez, L., Doffinger, R., Teichmann, S. A., Fisher, A. J., Pizzuto, M. S., de Marco, A., Corti, D., Hosmillo, M., Lee, J. H., James, L. C., Thukral, L., Veesler, D., Sigal, A., Sampaziotis, F., Goodfellow, I. G., Sato, K., and Gupta, R. K.
- Subjects
Adult ,Male ,COVID-19 Vaccines ,Virus Replication ,Membrane Fusion ,Antibodies ,Cell Line ,Tissue Culture Techniques ,Chlorocebus aethiops ,80 and over ,Animals ,Humans ,Viral ,Neutralizing ,Lung ,Aged ,Multidisciplinary ,Virulence ,SARS-CoV-2 ,Immune Sera ,Cell Membrane ,Serine Endopeptidases ,COVID-19 ,Convalescence ,Middle Aged ,Virus Internalization ,Spike Glycoprotein ,Intestines ,Coronavirus ,Nasal Mucosa ,Mutation ,Female ,Angiotensin-Converting Enzyme 2 ,Aged, 80 and over ,Antibodies, Neutralizing ,Antibodies, Viral ,Spike Glycoprotein, Coronavirus - Abstract
The SARS-CoV-2 Omicron BA.1 variant emerged in 20211 and has multiple mutations in its spike protein2. Here we show that the spike protein of Omicron has a higher affinity for ACE2 compared with Delta, and a marked change in its antigenicity increases Omicron’s evasion of therapeutic monoclonal and vaccine-elicited polyclonal neutralizing antibodies after two doses. mRNA vaccination as a third vaccine dose rescues and broadens neutralization. Importantly, the antiviral drugs remdesivir and molnupiravir retain efficacy against Omicron BA.1. Replication was similar for Omicron and Delta virus isolates in human nasal epithelial cultures. However, in lung cells and gut cells, Omicron demonstrated lower replication. Omicron spike protein was less efficiently cleaved compared with Delta. The differences in replication were mapped to the entry efficiency of the virus on the basis of spike-pseudotyped virus assays. The defect in entry of Omicron pseudotyped virus to specific cell types effectively correlated with higher cellular RNA expression of TMPRSS2, and deletion of TMPRSS2 affected Delta entry to a greater extent than Omicron. Furthermore, drug inhibitors targeting specific entry pathways3 demonstrated that the Omicron spike inefficiently uses the cellular protease TMPRSS2, which promotes cell entry through plasma membrane fusion, with greater dependency on cell entry through the endocytic pathway. Consistent with suboptimal S1/S2 cleavage and inability to use TMPRSS2, syncytium formation by the Omicron spike was substantially impaired compared with the Delta spike. The less efficient spike cleavage of Omicron at S1/S2 is associated with a shift in cellular tropism away from TMPRSS2-expressing cells, with implications for altered pathogenesis.
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- 2022
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5. A high-resolution carbon-isotope record of the Turonian stage correlated to a siliciclastic basin fill: Implications for mid-Cretaceous sea-level change
- Author
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Uličný, D., Jarvis, I., Gröcke, D.R., Čech, S., Laurin, J., Olde, K., Trabucho-Alexandre, J., Švábenická, L., and Pedentchouk, N.
- Published
- 2014
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6. Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2
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Collier, D. A., Ferreira, I. A. T. M., Kotagiri, P., Datir, R. P., Lim, E. Y., Touizer, E., Meng, B., Abdullahi, A., Baker, S., Dougan, G., Hess, C., Kingston, N., Lehner, P. J., Lyons, P. A., Matheson, N. J., Owehand, W. H., Saunders, C., Summers, C., Thaventhiran, J. E. D., Toshner, M., Weekes, M. P., Maxwell, P., Shaw, A., Bucke, A., Calder, J., Canna, L., Domingo, J., Elmer, A., Fuller, S., Harris, J., Hewitt, S., Kennet, J., Jose, S., Kourampa, J., Meadows, A., O'Brien, C., Price, J., Publico, C., Rastall, R., Ribeiro, C., Rowlands, J., Ruffolo, V., Tordesillas, H., Bullman, B., Dunmore, B. J., Fawke, S., Graf, S., Hodgson, J., Huang, C., Hunter, K., Jones, E., Legchenko, E., Matara, C., Martin, J., Mescia, F., O'Donnell, C., Pointon, L., Pond, N., Shih, J., Sutcliffe, R., Tilly, T., Treacy, C., Tong, Z., Wood, J., Wylot, M., Bergamaschi, L., Betancourt, A., Bower, G., Cossetti, C., De Sa, A., Epping, M., Gleadall, N., Grenfell, R., Hinch, A., Huhn, O., Jackson, S., Jarvis, I., Krishna, B., Lewis, D., Marsden, J., Nice, F., Okecha, G., Omarjee, O., Perera, M., Potts, M., Richoz, N., Romashova, V., Yarkoni, N. S., Sharma, R., Stefanucci, L., Stephens, J., Strezlecki, M., Turner, L., D. D. De Bie E. M., Bunclark, K., Josipovic, M., Mackay, M., Michael, A., Rossi, S., Selvan, M., Spencer, S., Yong, C., Ansaripour, A., Mwaura, L., Patterson, C., Polwarth, G., Polgarova, P., di Stefano, G., Fahey, C., Michel, R., Bong, S. -H., Coudert, J. D., Holmes, E., Allison, J., Butcher, H., Caputo, D., Clapham-Riley, D., Dewhurst, E., Furlong, A., Graves, B., Gray, J., Ivers, T., Kasanicki, M., Le Gresley, E., Linger, R., Meloy, S., Muldoon, F., Ovington, N., Papadia, S., Phelan, I., Stark, H., Stirrups, K. E., Townsend, P., Walker, N., Webster, J., Smith, K. G. C., Bradley, J. R., Ceron-Gutierrez, L., Cortes-Acevedo, P., Barcenas-Morales, G., Linterman, M. A., Mccoy, L. E., Davis, C., Thomson, E., Mckinney, E., Doffinger, R., Wills, M., Gupta, R. K., Collier, Dami A [0000-0001-5446-4423], Datir, Rawlings P [0000-0003-0521-2144], Smith, Kenneth GC [0000-0003-3829-4326], Linterman, Michelle A [0000-0001-6047-1996], McCoy, Laura E [0000-0001-9503-7946], Thomson, Emma [0000-0003-1482-0889], Lyons, Paul A [0000-0001-7035-8997], Gupta, Ravindra K [0000-0001-9751-1808], and Apollo - University of Cambridge Repository
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Male ,0301 basic medicine ,Aging ,Secondary ,T-Lymphocytes ,Antibodies, Viral ,Neutralization ,0302 clinical medicine ,80 and over ,Medicine ,Viral ,Neutralizing ,Adult ,Aged ,Aged, 80 and over ,Antibodies, Neutralizing ,Autoantibodies ,B-Lymphocytes ,BNT162 Vaccine ,COVID-19 Vaccines ,Female ,Health Personnel ,Humans ,Immunization, Secondary ,Immunoglobulin A ,Immunoglobulin Class Switching ,Immunoglobulin G ,Immunologic Memory ,Inflammation ,Interferon-gamma ,Interleukin-2 ,Middle Aged ,SARS-CoV-2 ,Somatic Hypermutation, Immunoglobulin ,Spike Glycoprotein, Coronavirus ,Vaccination ,Vaccines, Synthetic ,Immunity ,Sars-Cov-2 ,Vaccines ,education.field_of_study ,Multidisciplinary ,biology ,Spike Glycoprotein ,030220 oncology & carcinogenesis ,Antibody ,Population ,Article ,Antibodies ,03 medical and health sciences ,Immune system ,Immunoglobulin ,education ,business.industry ,Synthetic ,Somatic Hypermutation ,Vaccine efficacy ,Coronavirus ,030104 developmental biology ,Immunization ,Immunology ,biology.protein ,business - Abstract
Although two-dose mRNA vaccination provides excellent protection against SARS-CoV-2, there is little information about vaccine efficacy against variants of concern (VOC) in individuals above eighty years of age1. Here we analysed immune responses following vaccination with the BNT162b2 mRNA vaccine2 in elderly participants and younger healthcare workers. Serum neutralization and levels of binding IgG or IgA after the first vaccine dose were lower in older individuals, with a marked drop in participants over eighty years old. Sera from participants above eighty showed lower neutralization potency against the B.1.1.7 (Alpha), B.1.351 (Beta) and P.1. (Gamma) VOC than against the wild-type virus and were more likely to lack any neutralization against VOC following the first dose. However, following the second dose, neutralization against VOC was detectable regardless of age. The frequency of SARS-CoV-2 spike-specific memory B cells was higher in elderly responders (whose serum showed neutralization activity) than in non-responders after the first dose. Elderly participants showed a clear reduction in somatic hypermutation of class-switched cells. The production of interferon-γ and interleukin-2 by SARS-CoV-2 spike-specific T cells was lower in older participants, and both cytokines were secreted primarily by CD4 T cells. We conclude that the elderly are a high-risk population and that specific measures to boost vaccine responses in this population are warranted, particularly where variants of concern are circulating., Nature, 596 (7872), ISSN:0028-0836, ISSN:1476-4687
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- 2021
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7. SARS-CoV-2 evolution during treatment of chronic infection
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Kemp, S. A., Collier, D. A., Datir, R. P., Ferreira, I. A. T. M., Gayed, S., Jahun, A., Hosmillo, M., Rees-Spear, C., Mlcochova, P., Lumb, I. U., Roberts, D. J., Chandra, A., Temperton, N., Baker, S., Dougan, G., Hess, C., Kingston, N., Lehner, P. J., Lyons, P. A., Matheson, N. J., Owehand, W. H., Saunders, C., Summers, C., Thaventhiran, J. E. D., Toshner, M., Weekes, M. P., Bucke, A., Calder, J., Canna, L., Domingo, J., Elmer, A., Fuller, S., Harris, J., Hewitt, S., Kennet, J., Jose, S., Kourampa, J., Meadows, A., O'Brien, C., Price, J., Publico, C., Rastall, R., Ribeiro, C., Rowlands, J., Ruffolo, V., Tordesillas, H., Bullman, B., Dunmore, B. J., Fawke, S., Graf, S., Hodgson, J., Huang, C., Hunter, K., Jones, E., Legchenko, E., Matara, C., Martin, J., Mescia, F., O'Donnell, C., Pointon, L., Pond, N., Shih, J., Sutcliffe, R., Tilly, T., Treacy, C., Tong, Z., Wood, J., Wylot, M., Bergamaschi, L., Betancourt, A., Bower, G., Cossetti, C., De Sa, A., Epping, M., Gleadall, N., Grenfell, R., Hinch, A., Huhn, O., Jackson, S., Jarvis, I., Lewis, D., Marsden, J., Nice, F., Okecha, G., Omarjee, O., Perera, M., Richoz, N., Romashova, V., Yarkoni, N. S., Sharma, R., Stefanucci, L., Stephens, J., Strezlecki, M., Turner, L., De Bie, E. M. D. D., Bunclark, K., Josipovic, M., Mackay, M., Rossi, S., Selvan, M., Spencer, S., Yong, C., Ansaripour, A., Michael, A., Mwaura, L., Patterson, C., Polwarth, G., Polgarova, P., di Stefano, G., Fahey, C., Michel, R., Bong, S. -H., Coudert, J. D., Holmes, E., Allison, J., Butcher, H., Caputo, D., Clapham-Riley, D., Dewhurst, E., Furlong, A., Graves, B., Gray, J., Ivers, T., Kasanicki, M., Le Gresley, E., Linger, R., Meloy, S., Muldoon, F., Ovington, N., Papadia, S., Phelan, I., Stark, H., Stirrups, K. E., Townsend, P., Walker, N., Webster, J., Robson, S. C., Loman, N. J., Connor, T. R., Golubchik, T., Martinez Nunez, R. T., Ludden, C., Corden, S., Johnston, I., Bonsall, D., Smith, C. P., Awan, A. R., Bucca, G., Estee Torok, M., Saeed, K., Prieto, J. A., Jackson, D. K., Hamilton, W. L., Snell, L. B., Moore, C., Harrison, E. M., Goncalves, S., Fairley, D. J., Loose, M. W., Watkins, J., Livett, R., Moses, S., Amato, R., Nicholls, S., Bull, M., Smith, D. L., Barrett, J., Aanensen, D. M., Curran, M. D., Parmar, S., Aggarwal, D., Shepherd, J. G., Parker, M. D., Glaysher, S., Bashton, M., Underwood, A. P., Pacchiarini, N., Loveson, K. F., Carabelli, A. M., Templeton, K. E., Langford, C. F., Sillitoe, J., de Silva, T. I., Wang, D., Kwiatkowski, D., Rambaut, A., O'Grady, J., Cottrell, S., Holden, M. T. G., Thomson, E. C., Osman, H., Andersson, M., Chauhan, A. J., Hassan-Ibrahim, M. O., Lawniczak, M., Alderton, A., Chand, M., Constantinidou, C., Unnikrishnan, M., Darby, A. C., Hiscox, J. A., Paterson, S., Martincorena, I., Robertson, D. L., Volz, E. M., Page, A. J., Pybus, O. G., Bassett, A. R., Ariani, C. V., Spencer Chapman, M. H., K. K., Li, Shah, R. N., Jesudason, N. G., Taha, Y., Mchugh, M. P., Dewar, R., Jahun, A. S., Mcmurray, C., Pandey, S., Mckenna, J. P., Nelson, A., Young, G. R., Mccann, C. M., Elliott, S., Lowe, H., Temperton, B., Roy, S., Price, A., Rey, S., Wyles, M., Rooke, S., Shaaban, S., de Cesare, M., Letchford, L., Silveira, S., Pelosi, E., Wilson-Davies, E., O'Toole, A., Hesketh, A. R., Stark, R., du Plessis, L., Ruis, C., Adams, H., Bourgeois, Y., Michell, S. L., Gramatopoulos, D., Edgeworth, J., Breuer, J., Todd, J. A., Fraser, C., Buck, D., John, M., Kay, G. L., Palmer, S., Peacock, S. J., Heyburn, D., Weldon, D., Robinson, E., Mcnally, A., Muir, P., Vipond, I. B., Boyes, J., Sivaprakasam, V., Salluja, T., Dervisevic, S., Meader, E. J., Park, N. R., Oliver, K., Jeffries, A. R., Ott, S., da Silva Filipe, A., Simpson, D. A., Williams, C., Masoli, J. A. H., Knight, B. A., Jones, C. R., Koshy, C., Ash, A., Casey, A., Bosworth, A., Ratcliffe, L., Xu-McCrae, L., Pymont, H. M., Hutchings, S., Berry, L., Jones, K., Halstead, F., Davis, T., Holmes, C., Iturriza-Gomara, M., Lucaci, A. O., Randell, P. A., Cox, A., Madona, P., Harris, K. A., Brown, J. R., Mahungu, T. W., Irish-Tavares, D., Haque, T., Hart, J., Witele, E., Fenton, M. L., Liggett, S., Graham, C., Swindells, E., Collins, J., Eltringham, G., Campbell, S., Mcclure, P. C., Clark, G., Sloan, T. J., Jones, C., Lynch, J., Warne, B., Leonard, S., Durham, J., Williams, T., Haldenby, S. T., Storey, N., Alikhan, N. -F., Holmes, N., Carlile, M., Perry, M., Craine, N., Lyons, R. A., Beckett, A. H., Goudarzi, S., Fearn, C., Cook, K., Dent, H., Paul, H., Davies, R., Blane, B., Girgis, S. T., Beale, M. A., Bellis, K. L., Dorman, M. J., Drury, E., Kane, L., Kay, S., Mcguigan, S., Nelson, R., Prestwood, L., Rajatileka, S., Batra, R., Williams, R. J., Kristiansen, M., Green, A., Justice, A., Mahanama, A. I. K., Samaraweera, B., Hadjirin, N. F., Quick, J., Poplawski, R., Kermack, L. M., Reynolds, N., Hall, G., Chaudhry, Y., Pinckert, M. L., Georgana, I., Moll, R. J., Thornton, A., Myers, R., Stockton, J., Williams, C. A., Yew, W. C., Trotter, A. J., Trebes, A., MacIntyre-Cockett, G., Birchley, A., Adams, A., Plimmer, A., Gatica-Wilcox, B., Mckerr, C., Hilvers, E., Jones, H., Asad, H., Coombes, J., Evans, J. M., Fina, L., Gilbert, L., Graham, L., Cronin, M., Kumziene-Summerhayes, S., Taylor, S., Jones, S., Groves, D. C., Zhang, P., Gallis, M., Louka, S. F., Starinskij, I., Jackson, C., Gourtovaia, M., Tonkin-Hill, G., Lewis, K., Tovar-Corona, J. M., James, K., Baxter, L., Alam, M. T., Orton, R. J., Hughes, J., Vattipally, S., Ragonnet-Cronin, M., Nascimento, F. F., Jorgensen, D., Boyd, O., Geidelberg, L., Zarebski, A. E., Raghwani, J., Kraemer, M. U. G., Southgate, J., Lindsey, B. B., Freeman, T. M., Keatley, J. -P., Singer, J. B., de Oliveira Martins, L., Yeats, C. A., Abudahab, K., Taylor, B. E. W., Menegazzo, M., Danesh, J., Hogsden, W., Eldirdiri, S., Kenyon, A., Mason, J., Robinson, T. I., Holmes, A., Hartley, J. A., Curran, T., Mather, A. E., Shankar, G., Jones, R., Howe, R., Morgan, S., Wastenge, E., Chapman, M. R., Mookerjee, S., Stanley, R., Smith, W., Peto, T., Eyre, D., Crook, D., Vernet, G., Kitchen, C., Gulliver, H., Merrick, I., Guest, M., Munn, R., Bradley, D. T., Wyatt, T., Beaver, C., Foulser, L., Churcher, C. M., Brooks, E., Smith, K. S., Galai, K., Mcmanus, G. M., Bolt, F., Coll, F., Meadows, L., Attwood, S. W., Davies, A., De Lacy, E., Downing, F., Edwards, S., Scarlett, G. P., Jeremiah, S., Smith, N., Leek, D., Sridhar, S., Forrest, S., Cormie, C., Gill, H. K., Dias, J., Higginson, E. E., Maes, M., Young, J., Wantoch, M., Jamrozy, D., Lo, S., Patel, M., Hill, V., Bewshea, C. M., Ellard, S., Auckland, C., Harrison, I., Bishop, C., Chalker, V., Richter, A., Beggs, A., Best, A., Percival, B., Mirza, J., Megram, O., Mayhew, M., Crawford, L., Ashcroft, F., Moles-Garcia, E., Cumley, N., Hopes, R., Asamaphan, P., Niebel, M. O., Gunson, R. N., Bradley, A., Maclean, A., Mollett, G., Blacow, R., Bird, P., Helmer, T., Fallon, K., Tang, J., Hale, A. D., Macfarlane-Smith, L. R., Harper, K. L., Carden, H., Machin, N. W., Jackson, K. A., Ahmad, S. S. Y., George, R. P., Turtle, L., O'Toole, E., Watts, J., Breen, C., Cowell, A., Alcolea-Medina, A., Charalampous, T., Patel, A., Levett, L. J., Heaney, J., Rowan, A., Taylor, G. P., Shah, D., Atkinson, L., Lee, J. C. D., Westhorpe, A. P., Jannoo, R., Lowe, H. L., Karamani, A., Ensell, L., Chatterton, W., Pusok, M., Dadrah, A., Symmonds, A., Sluga, G., Molnar, Z., Baker, P., Bonner, S., Essex, S., Barton, E., Padgett, D., Scott, G., Greenaway, J., Payne, B. A. I., Burton-Fanning, S., Waugh, S., Raviprakash, V., Sheriff, N., Blakey, V., Williams, L. -A., Moore, J., Stonehouse, S., Smith, L., Davidson, R. K., Bedford, L., Coupland, L., Wright, V., Chappell, J. G., Tsoleridis, T., Ball, J., Khakh, M., Fleming, V. M., Lister, M. M., Howson-Wells, H. C., Boswell, T., Joseph, A., Willingham, I., Duckworth, N., Walsh, S., Wise, E., Moore, N., Mori, M., Cortes, N., Kidd, S., Williams, R., Gifford, L., Bicknell, K., Wyllie, S., Lloyd, A., Impey, R., Malone, C. S., Cogger, B. J., Levene, N., Monaghan, L., Keeley, A. J., Partridge, D. G., Raza, M., Evans, C., Johnson, K., Abnizova, I., Aigrain, L., Ali, M., Allen, L., Anderson, R., Ariani, C., Austin-Guest, S., Bala, S., Bassett, A., Battleday, K., Beal, J., Beale, M., Bellany, S., Bellerby, T., Bellis, K., Berger, D., Berriman, M., Betteridge, E., Bevan, P., Binley, S., Bishop, J., Blackburn, K., Bonfield, J., Boughton, N., Bowker, S., Brendler-Spaeth, T., Bronner, I., Brooklyn, T., Buddenborg, S. K., Bush, R., Caetano, C., Cagan, A., Carter, N., Cartwright, J., Monteiro, T. C., Chapman, L., Chillingworth, T. -J., Clapham, P., Clark, R., Clarke, A., Clarke, C., Cole, D., Cook, E., Coppola, M., Cornell, L., Cornwell, C., Corton, C., Crackett, A., Cranage, A., Craven, H., Craw, S., Crawford, M., Cutts, T., Dabrowska, M., Davies, M., Dawson, J., Day, C., Densem, A., Dibling, T., Dockree, C., Dodd, D., Dogga, S., Dougherty, M., Dove, A., Drummond, L., Dudek, M., Durrant, L., Easthope, E., Eckert, S., Ellis, P., Farr, B., Fenton, M., Ferrero, M., Flack, N., Fordham, H., Forsythe, G., Francis, M., Fraser, A., Freeman, A., Galvin, A., Garcia-Casado, M., Gedny, A., Girgis, S., Glover, J., Goodwin, S., Gould, O., Gray, A., Gray, E., Griffiths, C., Gu, Y., Guerin, F., Hamilton, W., Hanks, H., Harrison, E., Harrott, A., Harry, E., Harvison, J., Heath, P., Hernandez-Koutoucheva, A., Hobbs, R., Holland, D., Holmes, S., Hornett, G., Hough, N., Huckle, L., Hughes-Hallet, L., Hunter, A., Inglis, S., Iqbal, S., Jackson, A., Jackson, D., Verdejo, C. J., Jones, M., Kallepally, K., Kay, K., Keatley, J., Keith, A., King, A., Kitchin, L., Kleanthous, M., Klimekova, M., Korlevic, P., Krasheninnkova, K., Lane, G., Langford, C., Laverack, A., Law, K., Lensing, S., Lewis-Wade, A., Liddle, J., Lin, Q., Lindsay, S., Linsdell, S., Long, R., Lovell, J., Mack, J., Maddison, M., Makunin, A., Mamun, I., Mansfield, J., Marriott, N., Martin, M., Mayho, M., Mccarthy, S., Mcclintock, J., Mchugh, S., Mcminn, L., Meadows, C., Mobley, E., Moll, R., Morra, M., Morrow, L., Murie, K., Nash, S., Nathwani, C., Naydenova, P., Neaverson, A., Nerou, E., Nicholson, J., Nimz, T., Noell, G. G., O'Meara, S., Ohan, V., Olney, C., Ormond, D., Oszlanczi, A., Pang, Y. F., Pardubska, B., Park, N., Parmar, A., Patel, G., Payne, M., Peacock, S., Petersen, A., Plowman, D., Preston, T., Puethe, C., Quail, M., Rajan, D., Rance, R., Rawlings, S., Redshaw, N., Reynolds, J., Reynolds, M., Rice, S., Richardson, M., Roberts, C., Robinson, K., Robinson, M., Robinson, D., Rogers, H., Rojo, E. M., Roopra, D., Rose, M., Rudd, L., Sadri, R., Salmon, N., Saul, D., Schwach, F., Scott, C., Seekings, P., Shirley, L., Simms, A., Sinnott, M., Sivadasan, S., Siwek, B., Sizer, D., Skeldon, K., Skelton, J., Slater-Tunstill, J., Sloper, L., Smerdon, N., Smith, C., Smith, J., Smith, K., Smith, M., Smith, S., Smith, T., Sneade, L., Soria, C. D., Sousa, C., Souster, E., Sparkes, A., Spencer-Chapman, M., Squares, J., Steed, C., Stickland, T., Still, I., Stratton, M., Strickland, M., Swann, A., Swiatkowska, A., Sycamore, N., Swift, E., Symons, E., Szluha, S., Taluy, E., Tao, N., Taylor, K., Thompson, S., Thompson, M., Thomson, M., Thomson, N., Thurston, S., Toombs, D., Topping, B., Tovar-Corona, J., Ungureanu, D., Uphill, J., Urbanova, J., Jansen Van, P., Vancollie, V., Voak, P., Walker, D., Walker, M., Waller, M., Ward, G., Weatherhogg, C., Webb, N., Wells, A., Wells, E., Westwood, L., Whipp, T., Whiteley, T., Whitton, G., Whitwham, A., Widaa, S., Williams, M., Wilson, M., Wright, S., Farr, B. W., Quail, M. A., Thurston, S. A. J., Bronner, I. F., Redshaw, N. M., Lensing, S. V., Balcazar, C. E., Gallagher, M. D., Williamson, K. A., Stanton, T. D., Michelsen, M. L., Warwick-Dugdale, J., Manley, R., Farbos, A., Harrison, J. W., Sambles, C. M., Studholme, D. J., Lackenby, A., Mbisa, T., Platt, S., Miah, S., Bibby, D., Manso, C., Hubb, J., Dabrera, G., Ramsay, M., Bradshaw, D., Schaefer, U., Groves, N., Gallagher, E., Lee, D., Williams, D., Ellaby, N., Hartman, H., Manesis, N., Patel, V., Ledesma, J., Twohig, K. A., Allara, E., Pearson, C., Cheng, J. K. J., Bridgewater, H. E., Frost, L. R., Taylor-Joyce, G., Brown, P. E., Tong, L., Broos, A., Mair, D., Nichols, J., Carmichael, S. N., Smollett, K. L., Nomikou, K., Aranday-Cortes, E., Johnson, N., Nickbakhsh, S., Vamos, E. E., Hughes, M., Rainbow, L., Eccles, R., Nelson, C., Whitehead, M., Gregory, R., Gemmell, M., Wierzbicki, C., Webster, H. J., Fisher, C. L., Signell, A. W., Betancor, G., Wilson, H. D., Nebbia, G., Flaviani, F., Cerda, A. C., Merrill, T. V., Wilson, R. E., Cotic, M., Bayzid, N., Thompson, T., Acheson, E., Rushton, S., O'Brien, S., Baker, D. J., Rudder, S., Aydin, A., Sang, F., Debebe, J., Francois, S., Vasylyeva, T. I., Zamudio, M. E., Gutierrez, B., Marchbank, A., Maksimovic, J., Spellman, K., Mccluggage, K., Morgan, M., Beer, R., Afifi, S., Workman, T., Fuller, W., Bresner, C., Angyal, A., Green, L. R., Parsons, P. J., Tucker, R. M., Brown, R., Whiteley, M., Rowe, W., Siveroni, I., Le-Viet, T., Gaskin, A., Johnson, R., Sharrocks, K., Blane, E., Modis, Y., Leigh, K. E., Briggs, J. A. G., van Gils, M. J., Smith, K. G. C., Bradley, J. R., Doffinger, R., Ceron-Gutierrez, L., Barcenas-Morales, G., Pollock, D. D., Goldstein, R. A., Smielewska, A., Skittrall, J. P., Gouliouris, T., Goodfellow, I. G., Gkrania-Klotsas, E., Illingworth, C. J. R., Mccoy, L. E., Gupta, R. K., Medical Microbiology and Infection Prevention, AII - Infectious diseases, Collier, Dami A [0000-0001-5446-4423], Jahun, Aminu [0000-0002-4585-1701], Temperton, Nigel [0000-0002-7978-3815], Modis, Yorgo [0000-0002-6084-0429], Briggs, John AG [0000-0003-3990-6910], Goldstein, Richard A [0000-0001-5148-4672], Skittrall, Jordan P [0000-0002-8228-3758], Gkrania-Klotsas, Effrossyni [0000-0002-0930-8330], McCoy, Laura E [0000-0001-9503-7946], Gupta, Ravindra K [0000-0001-9751-1808], and Apollo - University of Cambridge Repository
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0301 basic medicine ,Male ,Time Factors ,viruses ,Passive ,Antibodies, Viral ,CITIID-NIHR BioResource COVID-19 Collaboration ,2.1 Biological and endogenous factors ,Viral ,Aetiology ,Neutralizing ,Lung ,Phylogeny ,neutralising antibodies ,Infectivity ,education.field_of_study ,Genome ,Multidisciplinary ,Alanine ,biology ,High-Throughput Nucleotide Sequencing ,Viral Load ,Spike Glycoprotein ,Virus Shedding ,Adenosine Monophosphate ,Aged ,Antibodies, Neutralizing ,COVID-19 ,Chronic Disease ,Genome, Viral ,Humans ,Immune Evasion ,Immune Tolerance ,Immunization, Passive ,Immunosuppression Therapy ,Mutagenesis ,Mutant Proteins ,Mutation ,SARS-CoV-2 ,Spike Glycoprotein, Coronavirus ,Evolution, Molecular ,Infectious Diseases ,Pneumonia & Influenza ,Antibody ,Infection ,Viral load ,Biotechnology ,Evolution ,General Science & Technology ,antibody escape, Convalescent plasma ,030106 microbiology ,Population ,evasion ,Antibodies ,Virus ,Article ,Vaccine Related ,resistance ,03 medical and health sciences ,Immune system ,COVID-19 Genomics UK (COG-UK) Consortium ,Biodefense ,Genetics ,Viral shedding ,education ,COVID-19 Serotherapy ,QR355 ,Prevention ,Wild type ,Molecular ,Pneumonia ,Virology ,COVID-19 Drug Treatment ,Coronavirus ,Emerging Infectious Diseases ,Good Health and Well Being ,030104 developmental biology ,biology.protein ,Immunization ,immune suppression ,mutation - Abstract
The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for virus infection through the engagement of the human ACE2 protein1 and is a major antibody target. Here we show that chronic infection with SARS-CoV-2 leads to viral evolution and reduced sensitivity to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma, by generating whole-genome ultra-deep sequences for 23 time points that span 101 days and using in vitro techniques to characterize the mutations revealed by sequencing. There was little change in the overall structure of the viral population after two courses of remdesivir during the first 57 days. However, after convalescent plasma therapy, we observed large, dynamic shifts in the viral population, with the emergence of a dominant viral strain that contained a substitution (D796H) in the S2 subunit and a deletion (ΔH69/ΔV70) in the S1 N-terminal domain of the spike protein. As passively transferred serum antibodies diminished, viruses with the escape genotype were reduced in frequency, before returning during a final, unsuccessful course of convalescent plasma treatment. In vitro, the spike double mutant bearing both ΔH69/ΔV70 and D796H conferred modestly decreased sensitivity to convalescent plasma, while maintaining infectivity levels that were similar to the wild-type virus.The spike substitution mutant D796H appeared to be the main contributor to the decreased susceptibility to neutralizing antibodies, but this mutation resulted in an infectivity defect. The spike deletion mutant ΔH69/ΔV70 had a twofold higher level of infectivity than wild-type SARS-CoV-2, possibly compensating for the reduced infectivity of the D796H mutation. These data reveal strong selection on SARS-CoV-2 during convalescent plasma therapy, which is associated with the emergence of viral variants that show evidence of reduced susceptibility to neutralizing antibodies in immunosuppressed individuals.
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- 2021
8. Response of foraminiferal assemblages to precession-paced environmental variation in a mid-latitude seaway : late Turonian greenhouse of Central Europe
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Chroustová, M., Holcová, K., Laurin, J., Uličný, D., Hradecká, L., Hrnková, M., Čech, S., Hrouda, F., and Jarvis, I.
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geography - Published
- 2021
9. Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease
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Bergamaschi, L., Mescia, F., Turner, L., Hanson, A. L., Kotagiri, P., Dunmore, B. J., Ruffieux, H., de Sa, A., Huhn, O., Morgan, M. D., Gerber, P. P., Wills, M. R., Baker, S., Calero-Nieto, F. J., Doffinger, R., Dougan, G., Elmer, A., Goodfellow, I. G., Gupta, R. K., Hosmillo, M., Hunter, K., Kingston, N., Lehner, P. J., Matheson, N. J., Nicholson, J. K., Petrunkina, A. M., Richardson, S., Saunders, C., Thaventhiran, J. E. D., Toonen, E. J. M., Weekes, M. P., Gottgens, B., Toshner, M., Hess, C., Bradley, J. R., Lyons, P. A., Smith, K. G. C., Allison, J., Ansaripour, A., Betancourt, A., Bong, S. -H., Bower, G., Bucke, A., Bullman, B., Bunclark, K., Butcher, H., Calder, J., Canna, L., Caputo, D., Clapham-Riley, D., Cossetti, C., Coudert, J. D., de Bie, E. M. D. D., Dewhurst, E., di Stefano, G., Domingo, J., Epping, M., Fahey, C., Fawke, S., Fuller, S., Furlong, A., Gleadall, N., Graf, S., Graves, B., Gray, J., Grenfell, R., Harris, J., Hewitt, S., Hinch, A., Hodgson, J., Holmes, E., Huang, C., Ivers, T., Jackson, S., Jarvis, I., Jones, E., Kennet, J., Jose, S., Josipovic, M., Kasanicki, M., Kourampa, J., Laurenti, E., Legchenko, E., Le Gresley, E., Lewis, D., Linger, R., Mackay, M., Marioni, J. C., Marsden, J., Martin, J., Matara, C., Meadows, A., Meloy, S., Mende, N., Michael, A., Michel, R., Mwaura, L., Muldoon, F., Nice, F., O'Brien, C., O'Donnell, C., Okecha, G., Omarjee, O., Ovington, N., Owehand, W. H., Papadia, S., Patterson, C., Perera, M., Phelan, I., Pointon, L., Polgarova, P., Polwarth, G., Pond, N., Price, J., Publico, C., Rastall, R., Ribeiro, C., Richoz, N., Romashova, V., Rossi, S., Rowlands, J., Ruffolo, V., Yarkoni, N. S., Sharma, R., Shih, J., Selvan, M., Spencer, S., Stefanucci, L., Stark, H., Stephens, J., Stirrups, K. E., Strezlecki, M., Summers, C., Sutcliffe, R., Tilly, T., Tong, Z., Tordesillas, H., Treacy, C., Townsend, P., Walker, N., Webster, J., Wilson, N. K., Wood, J., Wylot, M., Yong, C., Mescia, Federica [0000-0002-2759-4027], Hanson, Aimee [0000-0002-0231-8771], Ruffieux, Helene [0000-0002-7113-2540], Morgan, Michael [0000-0003-0757-0711], Wills, Mark [0000-0001-8548-5729], Baker, Stephen [0000-0003-1308-5755], Dougan, Gordon [0000-0003-0022-965X], Gupta, Ravindra [0000-0001-9751-1808], Hosmillo, Myra [0000-0002-3514-7681], Kingston, Nathalie [0000-0002-9190-2231], Lehner, Paul [0000-0001-9383-1054], Matheson, Nicholas [0000-0002-3318-1851], Richardson, Sylvia [0000-0003-1998-492X], Thaventhiran, James [0000-0001-8616-074X], Weekes, Michael [0000-0003-3196-5545], Gottgens, Berthold [0000-0001-6302-5705], Toshner, Mark [0000-0002-3969-6143], Bradley, John [0000-0002-7774-8805], Lyons, Paul [0000-0001-7035-8997], Smith, Kenneth [0000-0003-3829-4326], Apollo - University of Cambridge Repository, and Collaboration, Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource
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0301 basic medicine ,Pathology ,medicine.medical_specialty ,Immunology ,Disease ,macromolecular substances ,immune pathology ,Biology ,CD8-Positive T-Lymphocytes ,Systemic inflammation ,Lymphocyte Activation ,Severity of Illness Index ,Article ,Oxidative Phosphorylation ,03 medical and health sciences ,recovery ,0302 clinical medicine ,Immunophenotyping ,Immune system ,Immunopathology ,Bystander effect ,medicine ,Immunology and Allergy ,Humans ,complement ,Longitudinal Studies ,systemic inflammation ,bystander CD8+ T cell ,SARS-CoV-2 ,Gene Expression Profiling ,Interleukin ,COVID-19 ,interferon ,Prognosis ,TNF-α ,Biomarkers ,Cytokines ,Disease Susceptibility ,Host-Pathogen Interactions ,Inflammation Mediators ,Phenotype ,Reactive Oxygen Species ,Transcriptome ,030104 developmental biology ,Infectious Diseases ,030220 oncology & carcinogenesis ,Tumor necrosis factor alpha ,medicine.symptom - Abstract
The kinetics of the immune changes in COVID-19 across severity groups have not been rigorously assessed. Using immunophenotyping, RNA sequencing, and serum cytokine analysis, we analyzed serial samples from 207 SARS-CoV2-infected individuals with a range of disease severities over 12 weeks from symptom onset. An early robust bystander CD8+ T cell immune response, without systemic inflammation, characterized asymptomatic or mild disease. Hospitalized individuals had delayed bystander responses and systemic inflammation that was already evident near symptom onset, indicating that immunopathology may be inevitable in some individuals. Viral load did not correlate with this early pathological response but did correlate with subsequent disease severity. Immune recovery is complex, with profound persistent cellular abnormalities in severe disease correlating with altered inflammatory responses, with signatures associated with increased oxidative phosphorylation replacing those driven by cytokines tumor necrosis factor (TNF) and interleukin (IL)-6. These late immunometabolic and immune defects may have clinical implications., Graphical abstract, The immune changes that underlie COVID-19 severity have not been fully defined. By analyzing a longitudinal cohort of COVID-19 patients and integrating inflammatory factors, immunophenotyping, and transcriptome data, Bergamaschi et al. identify both early and persistent immune changes that distinguish mild and/or asymptomatic from more severe disease.
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- 2021
10. Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies
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Collier, D. A., De Marco, A., Ferreira, I. A. T. M., Meng, B., Datir, R. P., Walls, A. C., Kemp, S. A., Bassi, J., Pinto, D., Silacci-Fregni, C., Bianchi, S., Tortorici, M. A., Bowen, J., Culap, K., Jaconi, S., Cameroni, E., Snell, G., Pizzuto, M. S., Pellanda, A. F., Garzoni, C., Riva, A., Baker, S., Dougan, G., Hess, C., Kingston, N., Lehner, P. J., Lyons, P. A., Matheson, N. J., Owehand, W. H., Saunders, C., Summers, C., Thaventhiran, J. E. D., Toshner, M., Weekes, M. P., Bucke, A., Calder, J., Canna, L., Domingo, J., Elmer, A., Fuller, S., Harris, J., Hewitt, S., Kennet, J., Jose, S., Kourampa, J., Meadows, A., O'Brien, C., Price, J., Publico, C., Rastall, R., Ribeiro, C., Rowlands, J., Ruffolo, V., Tordesillas, H., Bullman, B., Dunmore, B. J., Fawke, S., Graf, S., Hodgson, J., Huang, C., Hunter, K., Jones, E., Legchenko, E., Matara, C., Martin, J., Mescia, F., O'Donnell, C., Pointon, L., Pond, N., Shih, J., Sutcliffe, R., Tilly, T., Treacy, C., Tong, Z., Wood, J., Wylot, M., Bergamaschi, L., Betancourt, A., Bower, G., Cossetti, C., De Sa, A., Epping, M., Grenfell, R., Hinch, A., Huhn, O., Jackson, S., Jarvis, I., Lewis, D., Marsden, J., Nice, F., Okecha, G., Omarjee, O., Perera, M., Richoz, N., Romashova, V., Yarkoni, N. S., Sharma, R., Stefanucci, L., Stephens, J., Strezlecki, M., Turner, L., De Bie, E. M. D. D., Bunclark, K., Josipovic, M., Mackay, M., Rossi, S., Selvan, M., Spencer, S., Yong, C., Ansaripour, A., Michael, A., Mwaura, L., Patterson, C., Polwarth, G., Polgarova, P., di Stefano, G., Fahey, C., Michel, R., Bong, S. -H., Coudert, J. D., Holmes, E., Allison, J., Butcher, H., Caputo, D., Clapham-Riley, D., Dewhurst, E., Furlong, A., Graves, B., Gray, J., Ivers, T., Kasanicki, M., Le Gresley, E., Linger, R., Meloy, S., Muldoon, F., Ovington, N., Papadia, S., Phelan, I., Stark, H., Stirrups, K. E., Townsend, P., Walker, N., Webster, J., Mccoy, L. E., Smith, K. G. C., Bradley, J. R., Temperton, N., Ceron-Gutierrez, L., Barcenas-Morales, G., Robson, S. C., Loman, N. J., Connor, T. R., Golubchik, T., Martinez Nunez, R. T., Ludden, C., Corden, S., Johnston, I., Bonsall, D., Smith, C. P., Awan, A. R., Bucca, G., Torok, M. E., Saeed, K., Prieto, J. A., Jackson, D. K., Hamilton, W. L., Snell, L. B., Moore, C., Harrison, E. M., Goncalves, S., Fairley, D. J., Loose, M. W., Watkins, J., Livett, R., Moses, S., Amato, R., Nicholls, S., Bull, M., Smith, D. L., Barrett, J., Aanensen, D. M., Curran, M. D., Parmar, S., Aggarwal, D., Shepherd, J. G., Parker, M. D., Glaysher, S., Bashton, M., Underwood, A. P., Pacchiarini, N., Loveson, K. F., Carabelli, A. M., Templeton, K. E., Langford, C. F., Sillitoe, J., de Silva, T. I., Wang, D., Kwiatkowski, D., Rambaut, A., O'Grady, J., Cottrell, S., Holden, M. T. G., Thomson, E. C., Osman, H., Andersson, M., Chauhan, A. J., Hassan-Ibrahim, M. O., Lawniczak, M., Alderton, A., Chand, M., Constantinidou, C., Unnikrishnan, M., Darby, A. C., Hiscox, J. A., Paterson, S., Martincorena, I., Robertson, D. L., Volz, E. M., Page, A. J., Pybus, O. G., Bassett, A. R., Ariani, C. V., Spencer Chapman, M. H., K. K., Li, Shah, R. N., Jesudason, N. G., Taha, Y., Mchugh, M. P., Dewar, R., Jahun, A. S., Mcmurray, C., Pandey, S., Mckenna, J. P., Nelson, A., Young, G. R., Mccann, C. M., Elliott, S., Lowe, H., Temperton, B., Roy, S., Price, A., Rey, S., Wyles, M., Rooke, S., Shaaban, S., de Cesare, M., Letchford, L., Silveira, S., Pelosi, E., Wilson-Davies, E., Hosmillo, M., O'Toole, A., Hesketh, A. R., Stark, R., du Plessis, L., Ruis, C., Adams, H., Bourgeois, Y., Michell, S. L., Gramatopoulos, D., Edgeworth, J., Breuer, J., Todd, J. A., Fraser, C., Buck, D., John, M., Kay, G. L., Palmer, S., Peacock, S. J., Heyburn, D., Weldon, D., Robinson, E., Mcnally, A., Muir, P., Vipond, I. B., Boyes, J., Sivaprakasam, V., Salluja, T., Dervisevic, S., Meader, E. J., Park, N. R., Oliver, K., Jeffries, A. R., Ott, S., da Silva Filipe, A., Simpson, D. A., Williams, C., Masoli, J. A. H., Knight, B. A., Jones, C. R., Koshy, C., Ash, A., Casey, A., Bosworth, A., Ratcliffe, L., Xu-McCrae, L., Pymont, H. M., Hutchings, S., Berry, L., Jones, K., Halstead, F., Davis, T., Holmes, C., Iturriza-Gomara, M., Lucaci, A. O., Randell, P. A., Cox, A., Madona, P., Harris, K. A., Brown, J. R., Mahungu, T. W., Irish-Tavares, D., Haque, T., Hart, J., Witele, E., Fenton, M. L., Liggett, S., Graham, C., Swindells, E., Collins, J., Eltringham, G., Campbell, S., Mcclure, P. C., Clark, G., Sloan, T. J., Jones, C., Lynch, J., Warne, B., Leonard, S., Durham, J., Williams, T., Haldenby, S. T., Storey, N., Alikhan, N. -F., Holmes, N., Carlile, M., Perry, M., Craine, N., Lyons, R. A., Beckett, A. H., Goudarzi, S., Fearn, C., Cook, K., Dent, H., Paul, H., Davies, R., Blane, B., Girgis, S. T., Beale, M. A., Bellis, K. L., Dorman, M. J., Drury, E., Kane, L., Kay, S., Mcguigan, S., Nelson, R., Prestwood, L., Rajatileka, S., Batra, R., Williams, R. J., Kristiansen, M., Green, A., Justice, A., Mahanama, A. I. K., Samaraweera, B., Hadjirin, N. F., Quick, J., Poplawski, R., Kermack, L. M., Reynolds, N., Hall, G., Chaudhry, Y., Pinckert, M. L., Georgana, I., Moll, R. J., Thornton, A., Myers, R., Stockton, J., Williams, C. A., Yew, W. C., Trotter, A. J., Trebes, A., MacIntyre-Cockett, G., Birchley, A., Adams, A., Plimmer, A., Gatica-Wilcox, B., Mckerr, C., Hilvers, E., Jones, H., Asad, H., Coombes, J., Evans, J. M., Fina, L., Gilbert, L., Graham, L., Cronin, M., Kumziene-Summerhayes, S., Taylor, S., Jones, S., Groves, D. C., Zhang, P., Gallis, M., Louka, S. F., Starinskij, I., Jackson, C., Gourtovaia, M., Tonkin-Hill, G., Lewis, K., Tovar-Corona, J. M., James, K., Baxter, L., Alam, M. T., Orton, R. J., Hughes, J., Vattipally, S., Ragonnet-Cronin, M., Nascimento, F. F., Jorgensen, D., Boyd, O., Geidelberg, L., Zarebski, A. E., Raghwani, J., Kraemer, M. U. G., Southgate, J., Lindsey, B. B., Freeman, T. M., Keatley, J. -P., Singer, J. B., de Oliveira Martins, L., Yeats, C. A., Abudahab, K., Taylor, B. E. W., Menegazzo, M., Danesh, J., Hogsden, W., Eldirdiri, S., Kenyon, A., Mason, J., Robinson, T. I., Holmes, A., Hartley, J. A., Curran, T., Mather, A. E., Shankar, G., Jones, R., Howe, R., Morgan, S., Wastenge, E., Chapman, M. R., Mookerjee, S., Stanley, R., Smith, W., Peto, T., Eyre, D., Crook, D., Vernet, G., Kitchen, C., Gulliver, H., Merrick, I., Guest, M., Munn, R., Bradley, D. T., Wyatt, T., Beaver, C., Foulser, L., Churcher, C. M., Brooks, E., Smith, K. S., Galai, K., Mcmanus, G. M., Bolt, F., Coll, F., Meadows, L., Attwood, S. W., Davies, A., De Lacy, E., Downing, F., Edwards, S., Scarlett, G. P., Jeremiah, S., Smith, N., Leek, D., Sridhar, S., Forrest, S., Cormie, C., Gill, H. K., Dias, J., Higginson, E. E., Maes, M., Young, J., Wantoch, M., Jamrozy, D., Lo, S., Patel, M., Hill, V., Bewshea, C. M., Ellard, S., Auckland, C., Harrison, I., Bishop, C., Chalker, V., Richter, A., Beggs, A., Best, A., Percival, B., Mirza, J., Megram, O., Mayhew, M., Crawford, L., Ashcroft, F., Moles-Garcia, E., Cumley, N., Hopes, R., Asamaphan, P., Niebel, M. O., Gunson, R. N., Bradley, A., Maclean, A., Mollett, G., Blacow, R., Bird, P., Helmer, T., Fallon, K., Tang, J., Hale, A. D., Macfarlane-Smith, L. R., Harper, K. L., Carden, H., Machin, N. W., Jackson, K. A., Ahmad, S. S. Y., George, R. P., Turtle, L., O'Toole, E., Watts, J., Breen, C., Cowell, A., Alcolea-Medina, A., Charalampous, T., Patel, A., Levett, L. J., Heaney, J., Rowan, A., Taylor, G. P., Shah, D., Atkinson, L., Lee, J. C. D., Westhorpe, A. P., Jannoo, R., Lowe, H. L., Karamani, A., Ensell, L., Chatterton, W., Pusok, M., Dadrah, A., Symmonds, A., Sluga, G., Molnar, Z., Baker, P., Bonner, S., Essex, S., Barton, E., Padgett, D., Scott, G., Greenaway, J., Payne, B. A. I., Burton-Fanning, S., Waugh, S., Raviprakash, V., Sheriff, N., Blakey, V., Williams, L. -A., Moore, J., Stonehouse, S., Smith, L., Davidson, R. K., Bedford, L., Coupland, L., Wright, V., Chappell, J. G., Tsoleridis, T., Ball, J., Khakh, M., Fleming, V. M., Lister, M. M., Howson-Wells, H. C., Boswell, T., Joseph, A., Willingham, I., Duckworth, N., Walsh, S., Wise, E., Moore, N., Mori, M., Cortes, N., Kidd, S., Williams, R., Gifford, L., Bicknell, K., Wyllie, S., Lloyd, A., Impey, R., Malone, C. S., Cogger, B. J., Levene, N., Monaghan, L., Keeley, A. J., Partridge, D. G., Raza, M., Evans, C., Johnson, K., Betteridge, E., Farr, B. W., Goodwin, S., Quail, M. A., Scott, C., Shirley, L., Thurston, S. A. J., Rajan, D., Bronner, I. F., Aigrain, L., Redshaw, N. M., Lensing, S. V., Mccarthy, S., Makunin, A., Balcazar, C. E., Gallagher, M. D., Williamson, K. A., Stanton, T. D., Michelsen, M. L., Warwick-Dugdale, J., Manley, R., Farbos, A., Harrison, J. W., Sambles, C. M., Studholme, D. J., Lackenby, A., Mbisa, T., Platt, S., Miah, S., Bibby, D., Manso, C., Hubb, J., Dabrera, G., Ramsay, M., Bradshaw, D., Schaefer, U., Groves, N., Gallagher, E., Lee, D., Williams, D., Ellaby, N., Hartman, H., Manesis, N., Patel, V., Ledesma, J., Twohig, K. A., Allara, E., Pearson, C., Cheng, J. K. J., Bridgewater, H. E., Frost, L. R., Taylor-Joyce, G., Brown, P. E., Tong, L., Broos, A., Mair, D., Nichols, J., Carmichael, S. N., Smollett, K. L., Nomikou, K., Aranday-Cortes, E., Johnson, N., Nickbakhsh, S., Vamos, E. E., Hughes, M., Rainbow, L., Eccles, R., Nelson, C., Whitehead, M., Gregory, R., Gemmell, M., Wierzbicki, C., Webster, H. J., Fisher, C. L., Signell, A. W., Betancor, G., Wilson, H. D., Nebbia, G., Flaviani, F., Cerda, A. C., Merrill, T. V., Wilson, R. E., Cotic, M., Bayzid, N., Thompson, T., Acheson, E., Rushton, S., O'Brien, S., Baker, D. J., Rudder, S., Aydin, A., Sang, F., Debebe, J., Francois, S., Vasylyeva, T. I., Zamudio, M. E., Gutierrez, B., Marchbank, A., Maksimovic, J., Spellman, K., Mccluggage, K., Morgan, M., Beer, R., Afifi, S., Workman, T., Fuller, W., Bresner, C., Angyal, A., Green, L. R., Parsons, P. J., Tucker, R. M., Brown, R., Whiteley, M., Bonfield, J., Puethe, C., Whitwham, A., Liddle, J., Rowe, W., Siveroni, I., Le-Viet, T., Gaskin, A., Johnson, R., Abnizova, I., Ali, M., Allen, L., Anderson, R., Ariani, C., Austin-Guest, S., Bala, S., Bassett, A., Battleday, K., Beal, J., Beale, M., Bellany, S., Bellerby, T., Bellis, K., Berger, D., Berriman, M., Bevan, P., Binley, S., Bishop, J., Blackburn, K., Boughton, N., Bowker, S., Brendler-Spaeth, T., Bronner, I., Brooklyn, T., Buddenborg, S. K., Bush, R., Caetano, C., Cagan, A., Carter, N., Cartwright, J., Monteiro, T. C., Chapman, L., Chillingworth, T. -J., Clapham, P., Clark, R., Clarke, A., Clarke, C., Cole, D., Cook, E., Coppola, M., Cornell, L., Cornwell, C., Corton, C., Crackett, A., Cranage, A., Craven, H., Craw, S., Crawford, M., Cutts, T., Dabrowska, M., Davies, M., Dawson, J., Day, C., Densem, A., Dibling, T., Dockree, C., Dodd, D., Dogga, S., Dougherty, M., Dove, A., Drummond, L., Dudek, M., Durrant, L., Easthope, E., Eckert, S., Ellis, P., Farr, B., Fenton, M., Ferrero, M., Flack, N., Fordham, H., Forsythe, G., Francis, M., Fraser, A., Freeman, A., Galvin, A., Garcia-Casado, M., Gedny, A., Girgis, S., Glover, J., Gould, O., Gray, A., Gray, E., Griffiths, C., Gu, Y., Guerin, F., Hamilton, W., Hanks, H., Harrison, E., Harrott, A., Harry, E., Harvison, J., Heath, P., Hernandez-Koutoucheva, A., Hobbs, R., Holland, D., Holmes, S., Hornett, G., Hough, N., Huckle, L., Hughes-Hallet, L., Hunter, A., Inglis, S., Iqbal, S., Jackson, A., Jackson, D., Verdejo, C. J., Jones, M., Kallepally, K., Kay, K., Keatley, J., Keith, A., King, A., Kitchin, L., Kleanthous, M., Klimekova, M., Korlevic, P., Krasheninnkova, K., Lane, G., Langford, C., Laverack, A., Law, K., Lensing, S., Lewis-Wade, A., Lin, Q., Lindsay, S., Linsdell, S., Long, R., Lovell, J., Mack, J., Maddison, M., Mamun, I., Mansfield, J., Marriott, N., Martin, M., Mayho, M., Mcclintock, J., Mchugh, S., Mcminn, L., Meadows, C., Mobley, E., Moll, R., Morra, M., Morrow, L., Murie, K., Nash, S., Nathwani, C., Naydenova, P., Neaverson, A., Nerou, E., Nicholson, J., Nimz, T., Noell, G. G., O'Meara, S., Ohan, V., Olney, C., Ormond, D., Oszlanczi, A., Pang, Y. F., Pardubska, B., Park, N., Parmar, A., Patel, G., Payne, M., Peacock, S., Petersen, A., Plowman, D., Preston, T., Quail, M., Rance, R., Rawlings, S., Redshaw, N., Reynolds, J., Reynolds, M., Rice, S., Richardson, M., Roberts, C., Robinson, K., Robinson, M., Robinson, D., Rogers, H., Rojo, E. M., Roopra, D., Rose, M., Rudd, L., Sadri, R., Salmon, N., Saul, D., Schwach, F., Seekings, P., Simms, A., Sinnott, M., Sivadasan, S., Siwek, B., Sizer, D., Skeldon, K., Skelton, J., Slater-Tunstill, J., Sloper, L., Smerdon, N., Smith, C., Smith, J., Smith, K., Smith, M., Smith, S., Smith, T., Sneade, L., Soria, C. D., Sousa, C., Souster, E., Sparkes, A., Spencer-Chapman, M., Squares, J., Steed, C., Stickland, T., Still, I., Stratton, M., Strickland, M., Swann, A., Swiatkowska, A., Sycamore, N., Swift, E., Symons, E., Szluha, S., Taluy, E., Tao, N., Taylor, K., Thompson, S., Thompson, M., Thomson, M., Thomson, N., Thurston, S., Toombs, D., Topping, B., Tovar-Corona, J., Ungureanu, D., Uphill, J., Urbanova, J., Van, P. J., Vancollie, V., Voak, P., Walker, D., Walker, M., Waller, M., Ward, G., Weatherhogg, C., Webb, N., Wells, A., Wells, E., Westwood, L., Whipp, T., Whiteley, T., Whitton, G., Widaa, S., Williams, M., Wilson, M., Wright, S., Harvey, W., Virgin, H. W., Lanzavecchia, A., Piccoli, L., Doffinger, R., Wills, M., Veesler, D., Corti, D., and Gupta, R. K.
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0301 basic medicine ,Male ,Models, Molecular ,Passive ,Antibodies, Viral ,Neutralization ,0302 clinical medicine ,Models ,Monoclonal ,80 and over ,Viral ,Neutralizing antibody ,Neutralizing ,Aged, 80 and over ,Vaccines ,Vaccines, Synthetic ,Multidisciplinary ,biology ,Antibodies, Monoclonal ,C500 ,Middle Aged ,C700 ,Spike Glycoprotein ,Vaccination ,Spike Glycoprotein, Coronavirus ,Female ,Angiotensin-Converting Enzyme 2 ,Antibody ,Aged ,Antibodies, Neutralizing ,COVID-19 ,COVID-19 Vaccines ,HEK293 Cells ,Humans ,Immune Evasion ,Immunization, Passive ,Mutation ,Neutralization Tests ,SARS-CoV-2 ,medicine.drug_class ,B100 ,Monoclonal antibody ,Antibodies ,Virus ,03 medical and health sciences ,Immune system ,medicine ,COVID-19 Serotherapy ,QR355 ,Synthetic ,Molecular ,Virology ,Coronavirus ,030104 developmental biology ,Immunization ,biology.protein ,030217 neurology & neurosurgery - Abstract
Transmission of SARS-CoV-2 is uncontrolled in many parts of the world; control is compounded in some areas by the higher transmission potential of the B.1.1.7 variant1, which has now been reported in 94 countries. It is unclear whether the response of the virus to vaccines against SARS-CoV-2 on the basis of the prototypic strain will be affected by the mutations found in B.1.1.7. Here we assess the immune responses of individuals after vaccination with the mRNA-based vaccine BNT162b22. We measured neutralizing antibody responses after the first and second immunizations using pseudoviruses that expressed the wild-type spike protein or a mutated spike protein that contained the eight amino acid changes found in the B.1.1.7 variant. The sera from individuals who received the vaccine exhibited a broad range of neutralizing titres against the wild-type pseudoviruses that were modestly reduced against the B.1.1.7 variant. This reduction was also evident in sera from some patients who had recovered from COVID-19. Decreased neutralization of the B.1.1.7 variant was also observed for monoclonal antibodies that target the N-terminal domain (9 out of 10) and the receptor-binding motif (5 out of 31), but not for monoclonal antibodies that recognize the receptor-binding domain that bind outside the receptor-binding motif. Introduction of the mutation that encodes the E484K substitution in the B.1.1.7 background to reflect a newly emerged variant of concern (VOC 202102/02) led to a more-substantial loss of neutralizing activity by vaccine-elicited antibodies and monoclonal antibodies (19 out of 31) compared with the loss of neutralizing activity conferred by the mutations in B.1.1.7 alone. The emergence of the E484K substitution in a B.1.1.7 background represents a threat to the efficacy of the BNT162b2 vaccine.
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- 2021
11. Effective control of SARS-CoV-2 transmission between healthcare workers during a period of diminished community prevalence of COVID-19
- Author
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Jones, N. K., Rivett, L., Sparkes, D., Forrest, S., Sridhar, S., Young, J., Pereira-Dias, J., Cormie, C., Gill, H., Reynolds, N., Wantoch, M., Routledge, M., Warne, B., Levy, J., Jimenez, W. D. C., Samad, F. N. B., Mcnicholas, C., Ferris, M., Gray, J., Gill, M., Curran, M. D., Fuller, S., Chaudhry, A., Shaw, A., Bradley, J. R., Hannon, G. J., Goodfellow, I. G., Dougan, G., Smith, K. G. C., Lehner, P. J., Wright, G., Matheson, N. J., Baker, S., Weekes, M. P., Bradley, J., Goodfellow, I., Gupta, R., Lyons, P. A., Torok, M. E., Toshner, M., Kean, I., Caddy, S., Caller, L., Feltwell, T., Hall, G., Hamilton, W., Hosmillo, M., Houldcroft, C., Jahun, A., Khokhar, F., Meredith, L., Yakovleva, A., Butcher, H., Caputo, D., Clapham-Riley, D., Dolling, H., Furlong, A., Graves, B., Gresley, E. L., Kingston, N., Papadia, S., Stark, H., Stirrups, K. E., Webster, J., Calder, J., Harris, J., Hewitt, S., Kennet, J., Meadows, A., Rastall, R., Brien, C. O., Price, J., Publico, C., Rowlands, J., Ruffolo, V., Tordesillas, H., Hannon, G., Brookes, K., Canna, L., Cruz, I., Dempsey, K., Elmer, A., Escoffery, N., Jones, H., Ribeiro, C., Saunders, C., Wright, A., Nyagumbo, R., Roberts, A., Bucke, A., Hargreaves, S., Johnson, D., Narcorda, A., Read, D., Sparke, C., Worboys, L., Lagadu, K., Mactavous, L., Gould, T., Raine, T., Mather, C., Ramenatte, N., Vallier, A. -L., Kasanicki, M., Eames, P. -J., Thake, L., Bartholomew, N., Brown, N., Curran, M., Parmar, S., Zhang, H., Bowring, A., Martell, G., Quinnell, N., Wright, J., Murphy, H., Dunmore, B. J., Legchenko, E., Graf, S., Huang, C., Hodgson, J., Hunter, K., Martin, J., Mescia, F., Odonnell, C., Pointon, L., Shih, J., Sutcliffe, R., Tilly, T., Tong, Z., Treacy, C., Wood, J., Bergamaschi, L., Betancourt, A., Bowyer, G., De Sa, A., Epping, M., Hinch, A., Huhn, O., Jarvis, I., Lewis, D., Marsden, J., Mccallum, S., Nice, F., Omarjee, O., Perera, M., Romashova, N., Strezlecki, M., Yarkoni, N. S., Turner, L., Bailey, B., Doughton, R., Workman, C., Trotter, C., David, W., Jimenez, C., Jones, Nick K [0000-0003-4475-7761], Sridhar, Sushmita [0000-0001-7453-7482], Hannon, Gregory J [0000-0003-4021-3898], Goodfellow, Ian G [0000-0002-9483-510X], Lehner, Paul J [0000-0001-9383-1054], Matheson, Nicholas J [0000-0002-3318-1851], Weekes, Michael P [0000-0003-3196-5545], and Apollo - University of Cambridge Repository
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0301 basic medicine ,Male ,Infectious Disease Transmission ,global health ,Occupational safety and health ,Hospitals, University ,Patient-to-Professional ,0302 clinical medicine ,COVID-19 Testing ,Patient Admission ,Nasopharynx ,Pandemic ,Epidemiology ,Prevalence ,Medicine ,Infection control ,Mass Screening ,030212 general & internal medicine ,Viral ,Biology (General) ,Family Characteristics ,General Neuroscience ,Infectious ,human biology ,virus diseases ,General Medicine ,Middle Aged ,Hospitals ,3. Good health ,virology ,Community-Acquired Infections ,Occupational Diseases ,England ,epidemiology ,Female ,medicine.symptom ,Symptom Assessment ,Coronavirus Infections ,Hospital Units ,Adult ,medicine.medical_specialty ,Infectious Disease Transmission, Patient-to-Professional ,QH301-705.5 ,Health Personnel ,infectious disease ,Science ,Pneumonia, Viral ,Real-Time Polymerase Chain Reaction ,Asymptomatic ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,Betacoronavirus ,Disease Transmission ,Disease Transmission, Infectious ,Humans ,human ,Human Biology and Medicine ,Hospitals, Teaching ,Pandemics ,Mass screening ,Asymptomatic Diseases ,emerging pathogens ,University ,Infection Control ,General Immunology and Microbiology ,business.industry ,Clinical Laboratory Techniques ,SARS-CoV-2 ,Teaching ,COVID-19 ,Pneumonia ,medicine ,occupational health ,Contact Tracing ,Program Evaluation ,030104 developmental biology ,Epidemiology and Global Health ,Emergency medicine ,business ,Research Advance ,Contact tracing - Abstract
Previously, we showed that 3% (31/1032)of asymptomatic healthcare workers (HCWs) from a large teaching hospital in Cambridge, UK, tested positive for SARS-CoV-2 in April 2020. About 15% (26/169) HCWs with symptoms of coronavirus disease 2019 (COVID-19) also tested positive for SARS-CoV-2 (Rivett et al., 2020). Here, we show that the proportion of both asymptomatic and symptomatic HCWs testing positive for SARS-CoV-2 rapidly declined to near-zero between 25th April and 24th May 2020, corresponding to a decline in patient admissions with COVID-19 during the ongoing UK ‘lockdown’. These data demonstrate how infection prevention and control measures including staff testing may help prevent hospitals from becoming independent ‘hubs’ of SARS-CoV-2 transmission, and illustrate how, with appropriate precautions, organizations in other sectors may be able to resume on-site work safely.
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- 2020
12. The lifecycle of mid-ocean ridge seamounts and their prodigious flank collapses
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Hunt, J.E. and Jarvis, I.
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- 2020
- Full Text
- View/download PDF
13. Chapter 11 - Carbon Isotope Stratigraphy
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Cramer, B.D. and Jarvis, I.
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- 2020
- Full Text
- View/download PDF
14. Allostratigraphy and biostratigraphy of the Upper Cretaceous (Coniacian-Santonian) Western Canada Foreland Basin
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Landman, Neil H., Plint, A. Guy, Walaszczyk, Ireneusz, Hooper, Beth (Elizabeth A.), Grifi, Meriem D., Gröcke, D. R. (Darren R.), Trabucho Alexandre, João P., Jarvis, I. (Ian), American Museum of Natural History Library, Landman, Neil H., Plint, A. Guy, Walaszczyk, Ireneusz, Hooper, Beth (Elizabeth A.), Grifi, Meriem D., Gröcke, D. R. (Darren R.), Trabucho Alexandre, João P., and Jarvis, I. (Ian)
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Alberta ,Canada, Western ,Cretaceous ,Geology ,Geology, Stratigraphic ,Mollusks, Fossil ,Paleontology ,Paleontology, Stratigraphic ,Sedimentary basins ,Stratigraphic correlation
15. Allostratigraphy and biostratigraphy of the Upper Cretaceous (Coniacian-Santonian) Western Canada Foreland Basin. (Bulletin of the American Museum of Natural History, no. 414)
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Grifi, Meriem D., Gröcke, D. R. (Darren R.), Hooper, Beth (Elizabeth A.), Jarvis, I. (Ian), Landman, Neil H., Plint, A. Guy, Trabucho Alexandre, João P., Walaszczyk, Ireneusz, American Museum of Natural History Library, Grifi, Meriem D., Gröcke, D. R. (Darren R.), Hooper, Beth (Elizabeth A.), Jarvis, I. (Ian), Landman, Neil H., Plint, A. Guy, Trabucho Alexandre, João P., and Walaszczyk, Ireneusz
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Alberta ,Canada, Western ,Cretaceous ,Geology ,Geology, Stratigraphic ,Mollusks, Fossil ,Paleontology ,Paleontology, Stratigraphic ,Sedimentary basins ,Stratigraphic correlation
16. Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission
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Rivett, L., Sridhar, S., Sparkes, D., Routledge, M., Jones, N. K., Forrest, S., Young, J., Pereira-Dias, J., Hamilton, W. L., Ferris, M., Torok, M. E., Meredith, L., Curran, M. D., Fuller, S., Chaudhry, A., Shaw, A., Samworth, R. J., Bradley, J. R., Dougan, G., Smith, K. G. C., Lehner, P. J., Matheson, N. J., Wright, G., Goodfellow, I. G., Baker, S., Weekes, M. P., Lyons, P. A., Toshner, M., Warne, B., Scott, J. B., Cormie, C., Gill, H., Kean, I., Maes, M., Reynolds, N., Wantoch, M., Caddy, S., Caller, L., Feltwell, T., Hall, G., Hosmillo, M., Houldcroft, C., Jahun, A., Khokhar, F., Yakovleva, A., Butcher, H., Caputo, D., Clapham-Riley, D., Dolling, H., Furlong, A., Graves, B., Gresley, E. L., Kingston, N., Papadia, S., Stark, H., Stirrups, K. E., Webster, J., Calder, J., Harris, J., Hewitt, S., Kennet, J., Meadows, A., Rastall, R., Brien, C. O., Price, J., Publico, C., Rowlands, J., Ruffolo, V., Tordesillas, H., Brookes, K., Canna, L., Cruz, I., Dempsey, K., Elmer, A., Escoffery, N., Jones, H., Ribeiro, C., Saunders, C., Wright, A., Nyagumbo, R., Roberts, A., Bucke, A., Hargreaves, S., Johnson, D., Narcorda, A., Read, D., Sparke, C., Warboys, L., Lagadu, K., Mactavous, L., Gould, T., Raine, T., Mather, C., Ramenatte, N., Vallier, A. -L., Kasanicki, M., Eames, P. -J., Mcnicholas, C., Thake, L., Bartholomew, N., Brown, N., Parmar, S., Zhang, H., Bowring, A., Martell, G., Quinnell, N., Wright, J., Murphy, H., Dunmore, B. J., Legchenko, E., Graf, S., Huang, C., Hodgson, J., Hunter, K., Martin, J., Mescia, F., O'Donnell, C., Pointon, L., Shih, J., Sutcliffe, R., Tilly, T., Tong, Z., Treacy, C., Wood, J., Bergamaschi, L., Betancourt, A., Bowyer, G., A. D., Sa, Epping, M., Hinch, A., Huhn, O., Jarvis, I., Lewis, D., Marsden, J., Mccallum, S., Nice, F., Rivett, Lucy [0000-0002-2781-9345], Lehner, Paul J [0000-0001-9383-1054], Matheson, Nicholas J [0000-0002-3318-1851], Goodfellow, Ian G [0000-0002-9483-510X], Weekes, Michael P [0000-0003-3196-5545], and Apollo - University of Cambridge Repository
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0301 basic medicine ,Male ,medicine ,global health ,0302 clinical medicine ,COVID-19 Testing ,Epidemiology ,Pandemic ,Health care ,Infection control ,030212 general & internal medicine ,Viral ,Biology (General) ,Asymptomatic Infections ,Nose ,0303 health sciences ,Transmission (medicine) ,COVID-19 ,SARS-CoV-2 ,emerging pathogens ,epidemiology ,human ,human biology ,infectious disease ,occupational health ,virology ,virus ,Betacoronavirus ,COVID-19 Vaccines ,Coronavirus Infections ,Female ,Humans ,Infection Control ,Pandemics ,Pneumonia, Viral ,Real-Time Polymerase Chain Reaction ,United Kingdom ,Clinical Laboratory Techniques ,Health Personnel ,General Neuroscience ,virus diseases ,General Medicine ,3. Good health ,medicine.anatomical_structure ,medicine.symptom ,Research Article ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,QH301-705.5 ,Science ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,education ,Asymptomatic ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,Internal medicine ,Throat ,Infectious disease (athletes) ,Human Biology and Medicine ,030304 developmental biology ,General Immunology and Microbiology ,business.industry ,Pneumonia ,030104 developmental biology ,Epidemiology and Global Health ,Carriage ,business - Abstract
Significant differences exist in the availability of healthcare worker (HCW) SARS-CoV-2 testing between countries, and existing programmes focus on screening symptomatic rather than asymptomatic staff. Over a 3 week period (April 2020), 1032 asymptomatic HCWs were screened for SARS-CoV-2 in a large UK teaching hospital. Symptomatic staff and symptomatic household contacts were additionally tested. Real-time RT-PCR was used to detect viral RNA from a throat+nose self-swab. 3% of HCWs in the asymptomatic screening group tested positive for SARS-CoV-2. 17/30 (57%) were truly asymptomatic/pauci-symptomatic. 12/30 (40%) had experienced symptoms compatible with coronavirus disease 2019 (COVID-19)>7 days prior to testing, most self-isolating, returning well. Clusters of HCW infection were discovered on two independent wards. Viral genome sequencing showed that the majority of HCWs had the dominant lineage B∙1. Our data demonstrates the utility of comprehensive screening of HCWs with minimal or no symptoms. This approach will be critical for protecting patients and hospital staff., eLife digest Patients admitted to NHS hospitals are now routinely screened for SARS-CoV-2 (the virus that causes COVID-19), and isolated from other patients if necessary. Yet healthcare workers, including frontline patient-facing staff such as doctors, nurses and physiotherapists, are only tested and excluded from work if they develop symptoms of the illness. However, there is emerging evidence that many people infected with SARS-CoV-2 never develop significant symptoms: these people will therefore be missed by ‘symptomatic-only’ testing. There is also important data showing that around half of all transmissions of SARS-CoV-2 happen before the infected individual even develops symptoms. This means that much broader testing programs are required to spot people when they are most infectious. Rivett, Sridhar, Sparkes, Routledge et al. set out to determine what proportion of healthcare workers was infected with SARS-CoV-2 while also feeling generally healthy at the time of testing. Over 1,000 staff members at a large UK hospital who felt they were well enough to work, and did not fit the government criteria for COVID-19 infection, were tested. Amongst these, 3% were positive for SARS-CoV-2. On closer questioning, around one in five reported no symptoms, two in five very mild symptoms that they had dismissed as inconsequential, and a further two in five reported COVID-19 symptoms that had stopped more than a week previously. In parallel, healthcare workers with symptoms of COVID-19 (and their household contacts) who were self-isolating were also tested, in order to allow those without the virus to quickly return to work and bolster a stretched workforce. Finally, the rates of infection were examined to probe how the virus could have spread through the hospital and among staff – and in particular, to understand whether rates of infection were greater among staff working in areas devoted to COVID-19 patients. Despite wearing appropriate personal protective equipment, healthcare workers in these areas were almost three times more likely to test positive than those working in areas without COVID-19 patients. However, it is not clear whether this genuinely reflects greater rates of patients passing the infection to staff. Staff may give the virus to each other, or even acquire it at home. Overall, this work implies that hospitals need to be vigilant and introduce broad screening programmes across their workforces. It will be vital to establish such approaches before ‘lockdown’ is fully lifted, so healthcare institutions are prepared for any second peak of infections.
- Published
- 2020
17. Do worms have brains?
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Wilson, J., McCoy, C., Jones, K., Jarvis, I., and Backas, A.
- Published
- 2008
18. NEURONAL DEFICITS IN IN VITRO MODELS OF DIABETES RELATED NEUROPATHIES
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Nuydens, R, Jarvis, I, De Jongh, R, Vissers, K, and Meert, T
- Published
- 2005
19. Neogene turbidite sequence on the Madeira Abyssal Plain: basin filling and diagenesis in the deep ocean
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Weaver, P.P.E., primary, Jarvis, I., additional, Lebreiro, S.M., additional, Alibés, B., additional, Baraza, J., additional, Howe, R., additional, and Rothwell, R.G., additional
- Published
- 1998
- Full Text
- View/download PDF
20. Chemostratigraphy of Madeira Abyssal Plain Miocene-Pleistocene turbidites, Site 950
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Jarvis, I., primary, Moreton, J., additional, and Gérard, M., additional
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- 1998
- Full Text
- View/download PDF
21. Oxidation fronts in Madeira Abyssal Plain turbidites: persistence of early diagenetic trace-element enrichments during burial, Site 950
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Thomson, J., primary, Jarvis, I., additional, Green, D.R.H., additional, and Green, D., additional
- Published
- 1998
- Full Text
- View/download PDF
22. Sample preparation for ICP-MS
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Jarvis, I., primary
- Published
- 1992
- Full Text
- View/download PDF
23. The lifecycle of mid-ocean ridge seamounts and their prodigious flank collapses
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Hunt, J.E., Jarvis, I., Hunt, J.E., and Jarvis, I.
- Abstract
Volcanic seamounts are spectacular bathymetric features representing ‘undersea mountains’ comparable in size to volcanic islands. They are often sites of active volcanism, represent major marine habitats, and contain potentially globally significant commodities of trace metals. However, we know comparatively little about how they form, the extent of their volcanic lifecycle, and what risks they pose from periodic flank collapse. Here, we study a uniquely extensive 43 Myr record of volcaniclastic and calciclastic turbidites accumulated on the Madeira Abyssal Plain in the NE Atlantic, which originate from large submarine landslides from the adjacent Great Meteor-Cruiser seamount complex on the flanks of the Mid-Atlantic Ridge. These turbidites present the first long-term temporal record of the recurrence, magnitude, and emplacement mechanism of seamount flank collapses from a single seamount complex throughout its lifecycle. Landslides from the Great Meteor-Cruiser seamount complex are comparable size to those from the Canary Islands, with average volumes of 30-40 km3 but can be as large as 130 km3, comparable to many volcanic island landslides. These seamount landslides were predominantly multi-stage failures similar to those form neighbouring volcanic islands, but in contrast occurred preferentially during sea-level lowstands. We show that volcanic seamounts above mantle plumes have long protracted lifecycles and that substantial flank failures are capable of occurring at all stages of development. Temporal change in turbidite composition has, for the first time, enabled reconstruction of the inception (around 43-45 Myrs ago), ascension (taking around 20-25 Myrs), emergence (after 30 Myrs) and later recession (last 9 Myrs), cessation in volcanism (last 4 Myrs) and subsidence of the seamounts (from 2 Myrs onwards). These seamounts above a mantle plume have taken around 26 Myrs to emergence above sea level from inception, while their volcanic island contemporaries onl
- Published
- 2019
24. Integrated, high-resolution allostratigraphic, biostratigraphic and carbon-isotope correlation of Coniacian strata (Upper Cretaceous), western Alberta and northern Montana
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Plint, A.G., Hooper, E.A., Grifi, M.D., Walaszczyk, I., Landman, N., Gröcke, D.R., Jarvis, I., Landman, Neil H., Plint, A. Guy, and Walaszczyk, Ireneus
- Abstract
Inoceramid bivalves are the dominant invertebrate fauna of the Coniacian and basal Santonian of the Western Canada Foreland Basin in western Alberta. In the upper lower Coniacian through to basal Santonian, six successive faunas are recognized, which provide the basis for corresponding, formally defined inoceramid zones. From bottom upward these are the zones of: Cremnoceramus crassus crassus /C. deformis deformis, Inoceramus gibbosus, Volviceramus koeneni, Volviceramus involutus, Sphenoceramus subcardissoides, and Sphenoceramus ex gr. pachti. Particular faunas represent assemblages known widely from the Euramerican biogeographic region, although they characterize mostly its northern, boreal area. The inoceramid-based biostratigraphic scheme allows correlation with other parts of the North American Western Interior and with parts of the Euramerican biogeographic region. The studied succession provides a good record of the Inoceramus gibbosus Zone, which characterizes the topmost lower Coniacian. This zone, first recognized from northern Germany, is usually absent, both in Europe and in North America, due to a stratigraphic gap resulting from a eustatic lowstand. The base of the middle Coniacian is marked by the abrupt appearance of the taxonomically variable Volviceramus fauna (V. koeneni (Müller), V. exogyroides (Meek and Hayden)), with associated Inoceramus undabundus Meek and Hayden and Volviceramus cardinalensis, newly described herein. Scaphites (Scaphites) ventricosus Meek and Hayden, the ammonite marker of the base of the middle Coniacian first appears in the late early Coniacian. The base of the upper Coniacian marks the first appearance of the characteristic northern inoceramid species Sphenoceramus subcardissoides (Schlüter), the appearance of which coincides with Scaphites (Scaphites) depressus Reeside, the ammonite marker of this boundary. Close to this boundary Volviceramus stotti also appears, which is newly described from the Canadian sections. The base of the Santonian corresponds to the abrupt appearance of Sphenoceramus ex gr. pachti (Arkhangelsky). The studied sections demonstrate that the appearance of new inoceramid faunas (lowest occurrence of Cremnoceramus crassus crassus (Petrascheck), of various species of Volviceramus, Sphenoceramus subcardissoides (Schlüter) and of S. ex gr. pachti) takes place immediately above major marine flooding surfaces, suggesting a close correspondence between evolutionary and/or migration events and episodes of relative sea-level rise.
- Published
- 2017
25. Geoglam: A Geo Initiative on Global Agricultural Monitoring
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Becker-Reshef, I., primary, Justice, C., additional, Whitcraft, A.K., additional, and Jarvis, I., additional
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- 2018
- Full Text
- View/download PDF
26. Genesis and diagenesis of Santonian to Early Campanian (Cretaceous) phosphatic chalks of the Anglo-Paris Basin
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Jarvis, I and Jarvis, Ian
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Geology, Stratigraphic ,Paleontology ,Cretaceous - Published
- 2016
27. Astronomical calibration and global correlation of the Santonian (Cretaceous) based on the marine carbon-isotope record
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Thibault, N., Jarvis, I., Voigt, S., Gale, A. S., Attree, K., and Jenkyns, H. C.
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geography - Published
- 2016
28. Intercontinental correlation of organic carbon and carbonate stable isotope records: evidence of climate and sea-level change during the Turonian (Cretaceous)
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Jarvis, I., Trabucho-Alexandre, João, Gröcke, D.R., Uličný, D., Laurin, J., and Sedimentology
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sea-level change ,climate change ,oxygen isotopes ,Carbon isotopes ,chemostratigraphy ,pCO2 ,Cretaceous ,geography - Abstract
Carbon (d13Corg, d13Ccarb) and oxygen (d18Ocarb) isotope records are presented for an expanded Upper Cretaceous (Turonian–Coniacian) hemipelagic succession cored in the central Bohemian Cretaceous Basin, Czech Republic. Geophysical logs, biostratigraphy and stable carbon isotope chemostratigraphy provide a high-resolution stratigraphic framework. The d13Ccarb and d13Corg profiles are compared, and the time series correlated with published coeval marine and non-marine isotope records from Europe, North America and Japan. All previously named Turonian carbon isotope events are identified and correlated at high-resolution between multiple sections, in different facies, basins and continents. The viability of using both carbonate and organic matter carbon isotope chemostratigraphy for improved stratigraphic resolution, for placing stage boundaries, and for intercontinental correlation is demonstrated, but anchoring the time series using biostratigraphic data is essential. An Early to Middle Turonian thermal maximum followed by a synchronous episode of stepped cooling throughout Europe during the Middle to Late Turonian is evidenced by bulk carbonate and brachiopod shell d18Ocarb data, and regional changes in the distribution and composition of macrofaunal assemblages. The Late Turonian Cool Phase in Europe was coincident with a period of long-term sea-level fall, with significant water-mass reorganization occurring during the mid-Late Turonian maximum lowstand. Falling D13C (d13Ccarb – d13Corg) trends coincident with two major cooling pulses, point to pCO2 drawdown accompanying cooling, but the use of paired carbon isotopes as a high-resolution pCO2 proxy is compromised in the low-carbonate sediments of the Bohemian Basin study section by diagenetic overprinting of the d13Ccarb record. Carbon isotope chemostratigraphy is confirmed as a powerful tool for testing and refining intercontinental and marine to terrestrial correlations.
- Published
- 2015
29. Geochemical and palynological sea-level proxies in hemipelagic sediments: A critical assessment from the Upper Cretaceous of the Czech Republic
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Olde, K., Jarvis, I., Uličný, D., Pearce, M.A., Trabucho-Alexandre, J., Čech, S., Gröcke, D.R., Laurin, J., Švábenická, L., Tocher, Bruce, Sedimentology, and Sedimentology
- Subjects
Palynology ,Palaeontology ,Dinoflagellate cysts ,Paleontology ,archaeology ,15. Life on land ,Biostratigraphy ,Oceanography ,geography ,Cretaceous ,13. Climate action ,Chemostratigraphy ,Sea-level change ,Dinocyst ,14. Life underwater ,Species richness ,Geology ,Sea level ,Ecology, Evolution, Behavior and Systematics ,Marine transgression ,Earth-Surface Processes - Abstract
Geochemical and palynological records are presented for an expanded Turonian–Coniacian hemipelagic succession in the central Bohemian Cretaceous Basin. A high-resolution stratigraphic framework is provided by biostratigraphy and organic carbon stable-isotope (δ13Corg) chemostratigraphy. A short-term (100 kyr) sea-level curve has been derived from high-resolution transgressive/regressive maxima / shore-proximity data established from basin-wide sediment geometries. The viability of geochemical and palynological parameters as potential sea-level proxies is tested against this independently derived sea-level record. Elemental chemostratigraphy is demonstrated to offer a reliable means of identifying medium- to long-term (0.4–2.4 Myr) sea-level trends. Manganese maxima are associated with periods of high sea level, and troughs with intervals of low sea level. Falling Mn contents accompany regression and rising values transgression. Major transgressive events associated with medium-term sea-level change are marked by sharp increases in Ti/Al ratios, but short-term (100 kyr) sea-level cycles are not consistently identified. Long-term δ13Corg variation and dinoflagellate cyst species richness are positively correlated and show similarities to the sea-level curve. Baseline trends have a cycle duration close to the 2.4 Myr long-eccentricity cycle. Dinocyst species richness closely follows short-term changes in sea level, with marked increases in dinocyst diversity coincident with most short-term flooding events. Periods of rapid sea-level rise caused an influx of a more diverse ‘outer shelf’ assemblage into the study area, together with the addition of shallower water species, some of which may have been transported into the central basin by hypopycnal flows. Changes in the proportion and abundance of peridinioid dinoflagellate cysts (principally Palaeohystrichophora infusorioides) were controlled principally by changing nutrient levels. Proximity proxies derived from geochemical and palynological data are not always consistent with the independent sea-level model. This exemplifies the need to understand all factors influencing elemental geochemical and palynological proxies before making simplistic sea level interpretations.
- Published
- 2015
30. High-dissolved solids and matrix effects in ICP-MS: methods towards improving determination limits for geoanalysis
- Author
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Jarvis, K, primary and Jarvis, I, additional
- Published
- 1993
- Full Text
- View/download PDF
31. Application of plasma spectrometry (ICP-AES, ICP-MS) to the analysis of sediments: an evaluation study using standard reference materials
- Author
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Jarvis, I, primary and Jarvis, K, additional
- Published
- 1993
- Full Text
- View/download PDF
32. Is there an alternative to fire assay for the determination of platinum group elements?
- Author
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Totland, M, primary, Jarvis, I, additional, and Jarvis, K, additional
- Published
- 1993
- Full Text
- View/download PDF
33. Use of anticoagulants and antiplatelet agents in stable outpatients with coronary artery disease and atrial fibrillation. International CLARIFY registry
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Fauchier, L., Greenlaw, N., Ferrari, R., Ford, I., Fox, K. M., Tardif, J. -C., Tendera, M., Steg, P. G., Sokn, F. J., Reid, C., Lang, I., Van den Branden, F., Cesar, L. M., Mattos, M. A., Nazar Luqman, H., Goudev, A., Dorian, P., Hu, D., Widimsky, P., Hassager, C., Danchin, N., Kaab, S., Vardas, P., Sulaiman, K. J., Al Mahmeed, W., Al Suwaidi, J., Al Rashdan, I., Abdulkader, F., Merkely, B., Kaul, U., Daly, K., Tavazzi, L., Jang, Y., Erglis, A., Laucevicius, A., Jamaluddin, A. N., Gamba, M. A., Tulevski, I. I., Stepinska, J., Morais, J., Macarie, C., Oganov, R., Shalnova, S., Al-Zaibag, M., Hou, M. K., Kamensky, G., Fras, Z., Kanic, V., Naidoo, D. P., Zamorano, J. L., Rickli, H., Jaussi, A., Sriratanasathavorn, C., Kalra, P., Lutai, M., Oleksandr, Nguyen, L. V., Henry, R., Ahuad Guerrero, A., Basara, M., Belcastro, F., Bertarini, J. A., Cazenave, C., Dreycopp, H., Egido, J., Estrella, J., Garofalo, D., Giordano, J., Lagioia, H., Lago, N., La Greca, R., Lema, L., Lopez Cabanillas, N., Luquez, H., Miller, C., Prada, E., Rodenas, P., Schena, R. G., Suarez, G., Tomatti, A., Colquhoun, D. M., Conradie, A., Cox, S., Cross, D., Fathi, R., Fitzgerald, B., Hamilton-Craig, I., Holt, G., Jayasinghe, S. R., Mai, N., Moolman, J., Motyer, R. A., Phillips, K., Rafter, A., Rahman, A., Rainbird, A., Scalia, G., Taylor, A., West, P., Alford, K., Amor, R., Astridge, P., Bastian, B., Bates, F., Doohan, M. M., Du Plooy, J., Ford, J. C., Kanagaratnam, L., Khoury, V., Parkin, R., Rogers, J., Sceats, G., Waldman, A., Wang, D., Wright, S., Ardill, J., Aylward, P., Beltrame, J. F., Bradley, J., Heddle, W., Joseph, M., Rajendran, S., Varughese, S., Brice, E., Hockings, B., Janssen, J., Kozlowski, A., O'Shea, J., Playford, D. A., Woollard, K., Ajani, A., Barron, G., Better, N., Chan, B., Chan, R., Cotroneo, J., Counsell, J. T., Eccleston, D. S., Forge, B. H. R., Hamer, A., Horrigan, M., Jelinek, V. M. J., Lew, R., O'Donnell, D., Panetta, F., Sebastian, M., Soward, A., Srivastava, P., Strathmore, N. F., Sylivris, S., Szto, G., Veth, V., Yip, T., Badr-Eslam, R., Kleemann, L., Steurer, G., Morz-Proszowski, B., Auhser, F., Teleky, U., Sepp, G., Beinhauer, A., Kero, D., Lavicka, C., Perger, T., Hadjiivanov, V., Feldner-Busztin, M., Mika, R., Filip, W., Mahr, A., Toplak, J., Millauer, M. G., Haralambus, P., Walcher, K., Karner, K. H., Ziak, E., Painsipp, P., Frank, U., Suntinger, A., Gritsch, W., Bode, G., Herrmann, R., Raffelsberger, R., Topf, H., Moser, E., Fochterle, J., Honsig, T., Mayr, K., Mayr, H., Kaserbacher, R., Dzien, A., Galehr, E., Felbermayer, M., Schwarz, R., Amini, R., Appeltants, H., Ballet, A., Bar, J. -P., Beckers, J., Bergen, J. -M., Berkenboom, G., Bernard, X., Bouvy, T., Briki, R., Claeys, M., Dascotte, Y., Davin, L., De Backer, T., De Keyser, F., De Meester, A., De Ridder, S., Dendale, P., Denef, K., Dhondt, E., Emonts, M., Geraedts, J. T. M., Goethals, M., Gregoire, J. -M., Haine, E., Herbots, T., Hoffer, E., Hutse, W. H. J., Kassab, A., Lafontaine, P., Lancellotti, P., Lefebvre, P., Lesseliers, H., Lozano, A., Maamar, R., Martinez, C., Noel, J. -F., Odent, G., Pasquet, A., Peperstraete, B., Purnode, P., Rogowsky, A., Rosseel, M., Salembier, J. -P., Surmont, P., Thermol, P., Vandeplas, A. M. F., Van de Walle, S., Vandergoten, P., Vanhauwaert, B. G., Vanneste, L., Vercammen, J., Verleyen, D., Vermander, D., Vervoort, G., Weytjens, C., Yanni, N., da Costa Pereira, A., Rocha de Lorenzo, A., Felice Castro Issa, A., Mahler Mioto, B., de Brito Vianna, C., Segre, C. A. W., Grupi, C. J., Okawabata, C., Favarato, D., Giusti Rossi, E., Fernandes, F., Pitella, F., Alvarez Ramires, F. J., Henpin Yue Cesena, F., Monteiro Ferreira, J. F., Junior, J. F., Tonet, L., Nastari, L., Machado Cesar, L., Gowdak, L. H., Matos, M. A., Moretti, M., Morgado, P. C., Vicente Amato, R., Tadeu Munhoz, R., Coimbra, S. R., Luqman, H. N., Yakovova, S., Mantcheva, M., Mincheva, V., Baurenski, L., Karastanev, K., Yordanova, V., Peneva, Y., Bailey, A., Wong, P., Fagan, M., Sabe-Affaki, G., Villasenor, F. M., Belisle, P., Son, W. K., Manyari, D. E., Giacomantonio, N., Lubelsky, B. J., Ezekiel, D., Leong, J. C. S., Grover, A., Vavougios, J., Pesant, Y., Kushner, A. M., Yeung, M. M. M., Vertes, G. E., Nasser-Sharif, F. J., Abdulla, A. H. K., Spensieri, D., Roy, A., Nguyen, T. T., Leclair, M., Morra, P., Everton Biglow, C., Baril, J. F., Lai, K., Wong, D. S., Martinho, V., Antoniadis, G. A., Searles, G. R., Rouse, D., Brisson, G., King Wong, S., Collette, R. S., M. S. C., Ho, Constance, C., Gendreau, R., Kellam, G. W., Cieza Lara, T. A., Boyrazian, H. A., Shamsuzzaman, M., Spink, D. R., Wong, A. P. T., Grewal, R. S., Che, C., Janes, J., Hechtenthal, N., Czarnecka, M., Saulnier, D., Levesque, G., Clavette, P. F., Kennedy, D. R., Kokis, A., Orenstein-Lyall, T. L., Shekhar Pandey, A., Robb, J., Verret, G., Czarnecki, W., Tsui, W. W. H., Perreault, F., Chouinard, G., Lafrance, G., Fullerton, G. M., Lavoie, J. P., Le Bouthillier, P., Tran, Q. H., Rodriguez Marrero, I., Ramadan, F. B., Talbot, P., Fazil, M. A., Cha, J. Y. -M., Garg, S., Chehayeb, R., Roy, B., Chan, Y. K., Harlos, H. E., Matheson, H. B., Patel, R., Vaz, G. F., Bhatt, J. S., Liu, E., Ashton, T. H., Sullivan, H., Quinn, L. P., Yared, K., Gupta, A., Sullivan, B., Campbell, J., Pallie, S., Kim, H., Vizel, S., Savard, D., Cherry, J. M., Gold, J., Chiu, S., Brouillette, G., Singh, R. R., Varma, S., Belanger, A., Myburgh, J. L., Berlingieri, J., Nisker, W., Boutros, G., Bakbak, A. I., Healley, W., Lasalle, L., Liu, F., Tu, C., Lv, S., Liu, X., Gao, H., Li, H., Zhao, H., Cao, L., Zhao, S., Wang, Y., Wu, D., Gu, F., Pan, G., Liu, P., Wang, X., Jiang, H., Li, J., Wang, J., Zhang, L., Ke, Y., Li, D., Chen, G., Xue, H., Jin, Q., Dong, W., Chen, Y., Fu, Z., Hu, H., Liang, Q., Yang, X., Zhou, Z., Xu, Z., Shao, C., Zhang, H., Pei, H., Song, L., Yu, M., Guan, T., Tang, Y., Wu, Y., Yang, M., Ceng, Q., Chen, X., Lin, L., Peng, Y., Yan, X., Yao, E., Zheng, X., Chen, B., Chen, H., Chen, W., Wang, R., Zheng, Y., Tan, H., Zhou, S., Zhou, Y., Liu, Z., Lu, Q., Lai, L., Pan, J., Wang, L., Fu, Q., Peng, J., Du, N., Lv, Y., Miao, W., Wang, H., Pu, Y., Wang, T., Dong, M., Gong, L., Zhang, J., Chen, Z., Jiang, Q., Ma, F., Xu, W., Dai, M., Wu, J., Yu, X., Chen, C., Huo, Y., Sun, L., Gao, W., Li, Z., Hu, Y., Chen, M., Li, G., Xue, M., Yao, Y., Pan, X., Sang, Z., Zhao, G., Hang, J., Ma, S., Zhang, G., Zhou, G., Li, W., Zhu, B., Yu, B., Zhu, S., Mao, J., Xu, M., Liu, Q., Huang, Q., Xie, Y., Feng, L., Chen, F., Chen, L., Liu, Y., Pei, X., Sun, A., Tian, Z., Wang, W., Yang, H., Yu, A., Zhang, M., Zhang, C., Guan, X., Zhou, X., Li, Y., Xing, Y., Chen, K., Luo, L., Dong, S., Zhang, Y., Ai, F., Xiong, C., Yang, F., Yang, K., Yan, J., Zhu, M., Zhang, A., Shan, G., Chen, J., Guo, J., Wu, S., Li, L., Liu, R., Yang, Y., Gao, X., Du, Z., Liang, L., Zhao, Y., Qian, J., He, L., Xiong, L., Chen, P., Peng, C., Zhu, J., Liu, J., Xie, X., Jiang, F., Li, A., Yang, Q., Cong, H., Guo, Y., Ren, N., Xiao, J., Zhao, R., Jiang, J., Deng, X., Wang, S., Wu, K., Zhang, X., Du, W., Shuang, D., Wei, J., Yuan, C., Li, F., Ou, X., Ou, Y., Yu, G., Zhang, S., Gao, J., Qian, Z., Wu, G., Zheng, S., Xu, D., Xie, J., Ren, W., Yao, X., Cai, B., Lv, J., Dong, J., Deng, Z., Bozkova, J., Carda, J., Dedkova, S., Dufka, A., Fridrich, J., Hodac, T., Jirmar, R., Kadleckova, A., Karlicek, M., Krupicka, J., Kuchar, J., Lavicka, V., Leso, J., Lorenc, Z., Micko, M., Navratil, P., Petrova, I., Povolna, P., Raisova, L., Raska, P., Ravlyk, V., Schlesingerova, S., Smrckova, E., Sternthal, P., Stursova, H., Vymetal, P., Zaoral, L., Wiggers, P., Markenvard, J., Andersen, L. 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W., Chlewicka, I., Brodzicki, P., Stasiuk, T., Szalkowski, P., Kulig, W., Maliszewski, M., Krolicka, K., Zdrojewska, J., Nikodemska, I., Szpak, A., Wrebiak-Trznadel, M., Prokop, A., Szulc, M., Olszewski, A., Kepa, W., Banach, J., Weglarz, M., Galuszka-Bilinska, A., Krolak, A., Cisowska-Drozd, E., Orzechowski, K., Jezewska, M., Adamaszek, K., Glanowska, G., Pitsch, T., Matuszewska, G., Nowowiejska-Wiewiora, A., Deren, M., Walawski, G., Soltysiak, M., Wysocki, R., Jarosinski, G., Drzewiecka, A., Lugowski, T., Jankowska, A., Blaszczak, P., Drozd, J., Lotocka, E., Duchowska, R., Sobczyk, D., Jarmuzek, P., Sidor, M., Adamczyk-Kot, D., Sudnik, J., Cygler, J., Skoczylas, I., Poprawa, B., Kisiel, L., Kossowska, U., Sikorska-Buczkowska, B., Modzelewska, K., Demianiuk, B., Streb, W., Mularek-Kubzdela, T., Bogdanski, P., Kazmierczak, E., Zimolag, R., Lorenc, J., Furtak, R., Regulska, A., Winter, M., Fic, M., Turek, P., Nowicka, E., Bryl, W., Lenartowska, L., Jerzykowska, O., Mackow, M., Gadzinski, W., Kacorzyk, R., Zalewska, D., Sadlowski, R., Slaboszewska, J., Gruchala, M., Frankiewicz, A., Walczewska, J., Adamkiewicz-Piejko, A., Chyrek, R., Jankowska, L., Correia, A., Girao, A., Herdade, A., Sequeira, A., Tavares E Taveira, A., Gonzaga, A., Ribeiro, A., Albuquerque, A., Fernandes, A., Estriga, A., Rocha De Almeida, A., Lourenco, A., Pereira, A., Faria, A., Carvalho De Moura, B., Camossa, C., Alves, C., Aguiar, C., Rodrigues, C., Wellenkamp, E., Lins, E., Fernandes De Sousa, F., Moreira Pinto, F., Matias, F., Silva Alves, G., Braganca, G., Proenca, G., Pego, G., Vinhas, H., Arroja, I., Rosa Pais, J., Silva E Sa, J., Vasconcelos, J., Matos, J., Freitas, J., Ferreira, J., Costa, J., Alcaravela, J., Mimoso, J., Antunes, J., Ferreira Dos Santos, J., Nobre Dos santos, J., Tito Martins, J., Fernandes, J., Chambel De Aguiar, J., Moreira, J., Carvalho, J., Forte De Carvalho, J., Calaca, J., Simoes, L., Lopes Antunes, L., Soares, L., Semedo, L., Macedo, L., Sargento, L., Basto, L., Carpinteiro, L., Rebelo, L., Oliveira, L., Catarino Carvalho, M., Alves Costa, M., Gamboa, M. C., Ferrao E Vasconcelos, M. F., Custodio, M. H., Mendonca, M. I., Pinto Vaz, M. J., Espiga De Macedo, M., Lazaro, M., Martins Oliveira, M., Pelicano, N., Lousada, N., Rodrigues, O., Matos Dias, P., Fonseca, P. F., Ferreira, P., Abreu, P. E., Monteiro, P., Seabra Gomes, R., Carvalho, R., Santos, R., Pires Pereira, R., Rosado Soares, R., Baptista, S., Reis Monteiro, S., Gil, V., Sanfins, V., Martins, V., Anghel, M., Arsenescu Georgescu, C., Babes, K., Banu, M., Beyer, R., Bratu, I., Bumbu, A., Capalneanu, R., Chioncel, O. D., Chiscaneanu, T., Christodorescu, R., Cindea Nica, N., Cinteza, M., Coman, S., Constantinescu, M., Craiu, E., Dan, G. A., Dan, D. C., Dan, A., David, C. M., Dorobantu, M., Farcas, D., Firastrau, V., Florescu, C., Ghicu, A., Giuca, A., Grigoriu, R., Ionescu, D. A., Ionescu, D. D., Iosipescu, L. C., Ivan, M. V., Lighezan, D., Magheru, S., Magherusan, M., Marinescu, S. M., Motoc, A. C., Musetescu, R., Rau, M., Rotaru, L., Rus, H., Sirbu, O., Sorodoc, L., Spinu, C. M., Stanciulescu, G., Statescu, C., Toringhibel, M., Trambitas, R., Trocan, N., Tudose, A., Vinereanu, D., Zagreanu, M., Dymova, D., Semenova, N., Zherebtsova, A., Fedoskin, V., Gurianova, N., Bolotova, N., Knyazeva, V., Spitsina, T., Sytilina, N., Atamanchuk, N., Giorgadze, M., Zarechnova, S., Kutuzova, S., Sharapova, Y., Stelmakh, I., Sinyukova, O., Rostik, S., Evtukhova, L., Sukhanova, L., Makhieva, T., Tereshko, S., Kolesnikov, V., Kochurov, E., Marchenko, B., Nurgalieva, S., Galeeva, Z., Andreicheva, E., Zakirova, V., Baleeva, L., Minsafina, A., Borodina, N., Arkhipova, Y., Krechunova, T., Scherbak, M., Merkhi, A., Aksyutina, N., Ratovskaya, O., Suglobova, E., Kozhelenko, Y., Potapova, E., Poluyanova, G., Naberezhnova, N., Daniels, E., Atueva, K., Tsaryabina, L., Kurekhyan, A., Khishova, N., Dubinina, E., Demina, O., Mochkina, P., Bukanina, E., Tolpygina, S., Polyanskaya, Y., Malysheva, A., Kheliya, T., Serazhim, A., Voronina, V., Lukina, Y., Dubinskaya, R., Dmitrieva, N., Kuzyakina, M., Khartova, N., Bokuchava, N., Smirnova, E., Esenokova, A., Pavlova, Y., Smirnova, O., Astrakhantseva, P., Bykovskaya, S., Charikova, O., Berdnik, K., Karaseva, T., Zhabina, L., Oleinikova, N., Dzhkha, O., Grigoryan, S., Yakovenko, E., Ivaschenko, T., Kiseleva, I., Shokina, T., Novikova, M., Khodanov, A., Popova, L., Latyntseva, L., Kilaberiya, O., Makarenkova, K., Nosova, N., Gerasimova, T., Boikova, L., Sharapova, N., Kulikova, Y., Pasechnaya, N., Bulakhova, E., Kurochkina, S., Bratishko, I., Likhobabina, O., Panova, E., Voronina, N., Bizyaeva, N., Gusev, O., Nevolina, N., Arsentieva, T., Budanova, I., London, E., Melnikova, Khripun, A., Polyaeva, L., Osadchuk, E., Krasnoslobodskaya, O., Yakimova, N., Lugin, A., Sosnova, Y., Il'ina, E., Kositsina, G., Shanina, I., Kostomarova, S., Malgina, M., Omelchenko, M., Gorlova, I., Eidelman, S., Salakhova, A., Bondarenko, B., Sopia, R., Baboshina, N., Eliseeva, N., Tumarov, F., Petrochenko, N., Khudina, I., Arabadzhi, N., Samakhovets, V., Tkhorzhevskaya, L., Sinotova, T., Zherlitsyna, E., Minkin, S., Petrova, N., Tikhonov, Y., Shmakova, N., Abduvalieva, V., Kuzmicheva, M., Nikolaeva, L., Varezhnikova, O., Dmitrieva, T., Mikhailova, E., Yanina, Y., Kapustina, L., Vazhdaeva, Z., Golovina, G., Fedorova, N., Nikolaeva, I., Fillipova, O., Gareeva, L., Tuktarova, F., Khmelevskikh, N., Karnot, V., Golub, M., Surovtseva, I., Kulygina, V., Shelomova, N., Kruglova, I., Pokrovskaya, I., Rodina, O., Polkina, L., Biryukova, N., Filippova, E., Kotova, E., Ignatieva, T., Alekseeva, T., Gruznykh, L., Mozerova, E., Moksyuta, E., Kosachek, E., Srtumilenko, N., Baranova, O., Voronova, T., Bayakhchan, L., Grudtsina, I., Gorshkova, L., Shamsutdinova, O., Getman, M., Gorodilova, I., Karnaukhova, N., Rotenberger, V., Isaeva, L., Lebischak, G., Ryzhkova, V., Usoltseva, E., Mescharekova, D., Tavlueva, E., Mineeva, E., Stikhurova, M., Kosareva, L., Grechishkina, O., Nikishina, S., Ilyukhina, A., Gureeva, O., Soin, I., Erofeev, S., Lebedev, S., Kudryavtsev, L., Gamzatov, E., Maximchuk, N., Grekhova, L., Kolevatova, L., Kazakovtseva, M., Kolesova, O., Zharikova, L., Kukaleva, V., Starostina, N., Grushetskaya, I., Kazachkova, V., Pashentseva, I., Shimonenko, S., Sirazov, I., Chernozemova, A., Golubeva, O., Mingalaeva, S., Zatsarina, E., Kozlov, D., Davydova, N., Larina, O., Fayez Al-Habib, K., Al-Hersi, A., Al-Baker, H., Al-Faleh, H., Moberik, A., Radwan Arafah, M., Al-Shamiri, M., El-Shaer, F., Al Zaibag, M., Bdeir, M., Suliman, I., Mukhtar, A., Omar, H., Jamiel, A., Elkrail, A., Alanazy, M., Habab, M., Ashmak, K., Nourallah, R., Mak, K. H., Singh, B., Baldev, S., Chee, T. S., Koo, C. C., Low, L. P., Nair, V. P., K. S., Ng, Quek, S. S. S., Tan, E. H. M., A. L. R., Ng, Chuang, H. H., Kaliska, G., Murin, J., Hatalova, K., Gaspar, L., Simkova, I., Dubrava, J., Pjontek, J., Pella, D., Banikova, A., Szentivanyi, M., Kovar, F., Benacka, J., Gonos, I., Fazekas, F., Kycina, P., Poles, J., Pernat, A., Veternik, A., Cernic-Suligoj, N., Kerbev, M., Krajnc, I., Zagozen, P., Alam, A., Brown, B., Luke, B., Variava, E., Nethononda, R., Joubert, S., Matthews, P., Nkombua, L., Antia, V., Bhayat, J., George, S. K., Ranjith, N., Vawda, G. H. M., Govender, S., Soosiwala, I., Shein, K., Panajatovic, M., Flores, J., Khan, M. S. H., Blignaut, S., Coetzee, K., Burgess, L., Freeman, V., Theron, H. D., Arnau Vives, M. A., Abardia Oliva, F. J., Albero Martinez, V., Alegret Colomer, J. M., Alegria Ezquerra, E., Almeida Fernandez, C. A., Alvarenga Recalde, N., Alvarez Aunon, A., Alvarez Garcia, P., Amo Fernandez, C., Amoros Galito, C., Ancin Viguiristi, R., Antona Makoshi, J., Aparici Feal, M., Ardiaca Capell, A., Arnedillo Pardo, J., Arquero Garcia, G., Arrarte Esteban, V., Baquero Alonso, M., Barahona Perez, P., Bardaji Mayor, J. L., Barriales Alvarez, V., Batalla Celorio, A., Bierge Valero, D., Blanco Castineiras, J., Bosa Ojeda, F., Botana Penas, C., Brufau Redondo, H., Bruguera Cortada, J., Cabau Rubies, J., Cabrera Sole, R., Calvo Iglesias, F., Cantabrana Miguel, S., Carrillo Cardoso, R., Casanovas Pie, M., Casas Gimenez, P., Castillo Luena, E., Castillo Moreno, J. A., Castillo Orive, M., Chirivella Gonzalez, A., Chopo Alcubilla, J. M., Climent Paya, V., Cobos Gil, M. A., Colomer Martin, J. L., Concepcion Clemente, A., Cortes Sanchez, R., Cremer Luengo, D., Darnes Soler, S., de Andres Novales, J., De Castro Aritmendiz, R., Delgado Prieto, J. L., Diaz Diaz, J. L., Escobar Cervantes, C., Ezcurdia Sasieta, J., Facila Rubio, L., Falces Salvador, C., Federico Zaragoza, P., Fernandez Alvarez, R., Fernandez de la Cigona, F., Fernandez Lazaro, L. A., Fernandez Leoz, L. C., Fernandez Mouzo, R., Fernandez-Valls Gomez, M., Ferreiro Rodriguez, B., Franco Aranda, C., Freire Corzo, J., Fuertes Alonso, J., Fuertes Beneitez, J., Galve Basilio, E., Garcia Garcia, C., Garcia Gonzalez, M. J., Garcia Ortego, S., Garcia Saavedra, V., Garcia-Moll Marimon, J., Gascuena Rubia, R., Gentille Lorente, D., Gervas Pavon, H., Gilabert Gomez, R., Gomez Barrado, J. J., Gomez Doblas, J. J., Gomez Martinez, M. J., Gonzalez Juanatey, C., Gonzalez Toda, V., Gonzalvez Ortega, M., Gordillo Higuero, E., Hernandez Afonso, J., Herrera Fernandez, D., Homs Espinach, E., Idoate Gastearena, A., Irurita Latasa, M., Izquierdo Gonzalez, R., Jaquet Herter, M., Lagares Carballo, M., Lastra Galan, J. A., Limeres Gonzalez, B., Lopez Aranda, M. A., Lopez Barreiro, L., Lopez Gomez, D., Lopez Granados, A., Lopez Mourino, V., Lopez-Sendon, J. L., Mainar Latorre, L., Marin Araez, E., Marin Ortuno, F., Martin Santana, A., Martinez Florez, J., Martinez Gonzalez, J., Martinez Rivero, J. F., Marzal Martin, D., Mazzanti Mignaqui, G. F., Melero Pita, A., Molina Laborda, E., Montero Gaspar, M. A., Mora Robles, J., Morales Gonzalez, J., Moreno Arribas, J., Moreno Casquete, M. T., Moro Lopez, J. A., Moya Lopez, C., Murga Eizagaechevarria, N., Narro Garcia, F., Navarro Manchon, J., Navas Navas, C., Novo Garcia, E., Nunez Gamero, J. A., Ordonez Espana, A., Ortiz de Murua Lopez, J. A., Orts Soler, E., Otero Chulian, E., Pastor Torres, L., Paule Sanchez, A. J., Paz Bermejo, M. A., Pena Perez, G., Perea Egido, J. A., Perez de Isla, L., Perez Ibiricu, S., Perez Martinez, M. A., Perez Paredes, M., Peris Domingo, E., Pinar Sopena, J., Pindado Rodriguez, C., Pinilla Lozano, M. J., Pinero Ramirez, C., Porras Ramos, Y., Ramos Ariznabarreta, F., Rayo Gutierrez, M., Roca Catalan, J. M., Rodriguez Almodovar, A., Rodriguez Collado, J., Rodriguez Fernandez, A., Rodriguez Fernandez, J. A., Rodriguez Hernandez, J. A., Rodriguez Tejero, I., Romeo Castillejo, I., Romero Alvira, D., Romero Hinojosa, J. A., Romero Menor, C., Rossi Sevillano, P., Rueda Calle, E. C., Rueda Soriano, J., Ruiz Perez, P., Sagastagoitia Gorostiza, T., Sainz Hidalgo, I., Sandin Rollan, M., Santaolalla Rodriguez, S., Santas Olmeda, E., Santos Iglesias, J. L., Sanz Rodriguez, M. L., Segura Laborda, I., Serrano Garcia, S., Sevilla Toral, B., Silva Melchor, L., Simarro Martin-Ambrioso, E., Sola Casado, R., Soriano Navarro, C., Soto Ruiz, M. I., Talavera Calle, P., Torres Diaz, P. L., Troncoso Gil, A., Trujillo Berraquero, F., Ulecia Martinez, M. A., Umaran Sanchez, J., Vaticon Herreros, C., Vazquez Garcia, A., Vega Barbado, J. L., Velasco Espejo-Saavedra, E., Vicente Vera, T., Vida Gutierrez, M., Villar Mariscal, C., Vives Bonato, G., Wu Amen, L., Yanes Bowden, G., Yanez Wonenburger, J. C., Zamorano Gomez, J. L., Zarauza Navarro, J., Monnier, P., Forclaz, A., Grobety, M., Schlueter, L., Vuille, C., Nacht, C. A., Evequoz, D., Ciaroni, S., Domine, F., Berube, J., Hellermann, J., Koller, R., Bourgeois, G., Engel, R., Niederberger, C., Stadler, P., Gnadinger, M., Schmied, C., Wettstein, T., Badorff, C., Hilti, P., Chetelat, C. A., Sepulcri, F., Brunner, H., Schindler, J., Kraus, M., Gmur, W., Bouranasompop, C., Jiraroj-ungkun, W., Lapanun, W., Vivekaphirat, V., Panpunnung, S., Dutsadeevettakul, S., Tasneeyapant, S., Ngamjanyaporn, P., Apitamsuntorn, S., Tantisiriwat, W., Suithichaiyakul, T., Kuanprasert, S., Wongcharoen, W., Phrommintikul, A., Musigchai, C., Chantrarat, T., Uerojanaungkul, P., Apinyasawat, S., Tangcharoen, T., Lertnantakul, M., Wasuwat, A., Harinasuta, J., See, O., Chaithiraphan, V., Boonyasirinant, T., Boonyapisit, W., Kittipovanonth, M., Buakhamsri, A., Piyayotai, D., Hutayanon, P., Junejo, S., Aiyegbayo, O., Ancliff, H., Bradshaw, C., Cervenak, R., Choi, H., George, E., Gilmour, I., Gough, D., Idrissi-Sbai, A., Ingham, J., Al-Khalidi, B., Liston, A., Mackrell, J., Pattison, I., Ramachandran, R., Ray, N., Reddy, G., Sen, I., Shetty, K., Singh, L., Stanley, M., Wallace, A., Weatherhead, M., Gilbert, T., McCansh, G., Higgins, S., Killeen, C., Cromarty, I., Franklin, P., Pinch, E., Dhesi, A., Dernedde, C., Lawrence, M., Simper, H., Noble, M., Dalton, G., Stevens, L., Berry, P., Hand, C., Oliver, R., Jones, H., Sampson, P., Taylor, N., Grogono, R., Dalrymple, J., Martin, A., Thurston, S., Elsby, K., Vallis, M., Morrison, G., Lang, C., Watson, A., Thomson, A., Dougall, H., La Hay, B., Compson, L., McCracken, A., Calder, J., Weber, F., Richmond, D., Brownlie, R., Brown, G., MacCowan, H., Heap, A., Perry, M., Holden, L. A., Scott, G., Haldane, N., Hood, S., Cullen, I., Bell, J., McNaught, P., Sharif, M., Dunn, J., Hay, D., Ross, S., Shaw, R., Hay, L., Langridge, S., Burns, R., Crawford, L., Kennedy, A., Logan, D., McAlavey, P., Brown, M., Costello, P., McLaren, G., Potter, A., McPherson, J., Drijfhout, M., Finlayson, J., Troup, D., Woodall, A., Pearce, J., Williams, S., Parkar, W., Yusuf, A., Benett, I., Bishop, P., Thomas, H., Caldwell, I., Ormiston, P., Kwok, S., Kanumilli, N., Saul, P., Milligan, H., Wilkinson, I., Vance, A., Paul, N., Paul, C., Shaikh, I., Ellis, R., Vites, N., Steeds, R., Goodwin, D., Aftab, A., Banham, S., Chauhan, N., Grocutt, M. S., Gupte, A., Jordan, R., Jheeta, B. S., Ladha, K., Nazir, M., Pal, R., Patel, R. P., McManus, R., Singal, A., Saunders, P., Syed, A. B., Bahal, A., Dau, H., Walker, D. M., McNeilly, R., Bolidai, A., MacCarthy, N., Lawton, D., Vardhani, M., Sengupta, G., Kinloch, D., Howie, F., Serrano-Garcia, A., Paget, S. E., Till, R., Seal, P., Morrell, J., Maxwell, T., Singh, G., Warden, D., Elias, R., Dixon, C., Pandey, R. K., Challenor, V., Davies, S., Gibbs, M., Gillet, A., Goldie, C., Jarvis, I., Johnson, P., Malden, M., Moore, J., Morton, C., Nehrig, K., Sheringham, P., Wilson, G., Halcox, J., O'Connor, I., Ling, K., Edwards, D., Charles, H., Weatherup, A., Davies, E., Watkins, N., Morgan, D., Davies, R., Lindsay, A., Beacock, D., Balai, R., Kirmond, P., Brindle, P., Bundy, C., Cahill, T., Dayani, A., Eavis, P., Mohr, S., Hayne, S., Krasucki, C., Micheals, M., Orpen, I., Parker, I., Sewell, R., Sharp, D., Smith, A., Stevens, A., Upton, J., Victory, J., Wernham, C., Davis, R., Mays, C., Andrews, M., Takhar, J., Travill, C., Choudhury, P., Matta, W., Ihonor, A., O'Dong, C., Rahman, S., Singer, P., Gillam, S., Bath, P. S., Razzaq, N., O'Toole, O., Rowe, P., Williams, H., Allcock, A., Tucker, A., Sprott, V., Kyd, K., Cunliffe, G., Arden, C., Bateman, A., Kassianos, G., Sinclair, D., Turner, C., Jagathesan, R., Sattar, F., Ashford, A., Chukwu, A., Taylor, H., Pradhan, R., Rundell, T., Howlett, R., Bietzk, R., Myint, M., Partington, M., O'Reilly, F., Baverstock, M., Dixon, S., Tennekoon, M., Brand, N., Haimes, P., Keller, P., Whetstone, S., Kovyrshyna, O., Rogozhyna, V., Kiver, T., Vasylenko, V., Kucheryava, L., Salimova, S., Alekseenko, V., Gukov, O., Myhailiv, I., Kardashevskaya, L., Prikolota, O., Bashkirtcev, O., Andreev, E., Tkachenko, L., Mospan, M., Batushkin, V., Safonova, L., Ogorodnichuk, A., Pustovit, S., Romanov, S., Burlakova, L., Voloshko, Y., Lafarenko, V., Vlasuk, Z., Leshchuk, O., Chushak, S., Koval, V., Stasuk, O., Pogrebna, O., Kornienko, S., Tikhonova, S., Fesenko, T., Kuzmina, T., Ushakov, O., Vechtomova, N., Potapska, L., Illushechkin, I., Kryvenkova, E., Lysunets, O., Tsygankov, O., Bardachenko, L., Voloshyna, L., Ginzburg, V., Franskyavichene, L., Korotich, T., Vyshnevaya, N., Bilous, N., Kulinich, S., Kulik, V., Sadykova, I., Berezhna, T., Molotyagina, S., Pham, M. H., Pham, H. T., Khong, N. H., K. B., Do, T. B., Le, P. A., Do, T. C., Do, Nguyen, N. Q., Q. H., Do, K. C., Vu, Pham, N. H., Pham, T. H. T., M. C., Ta, Phan, D. P., Nguyen, T. T. H., Pham, T. T. N., T. L., To, V. T., Le, Dang, L., Bui, L., Pham, T. T. H., Phan, H. H., Bui, T. T. H., Tuong, T. V. A., Nguyen, T. P., Nguyen, T. H., Nguyen, B. K., D. B., Vu, Pham, N. S., T. Q., Do, Pham, T. S., Dang, V. D., D. T., Le, V. C., Do, Nguyen, T. K. L., Luong, H. D., Luu, T. Q., Pham, N. V., Huynh, T. K., N. T. H., Tu, Ngo, K. A., Nguyen, T. T. C., Ong, T. T. L., Doan, V. B., Kim, T. B., T. N., Vo, Tran, T. T. T., Nguyen, T. A., Tran, V. D., Nguyen, A. K., Tran, A. C., Ngo, M. H., N. H., Vu, I. T., Ly, Tran, N. P. H., Tran, L. U. P., Nguyen, T. N., Tran, T. H., Truong, P. H., Mai, T. L., Hoang, V. S., Bui, C. M. A., Dang, V. P., Truong, Q. B., M. P., Vo, Nguyen, V. T., Chau, N. H., T. T. H., Ta, Dinh, H. N., Tran, H., Nguyen, H. K. N., Chung, A., Chung, E., Martina-Hooi, B., Angela, R., Ramoutar, P., Fillet, R., Tilluckdharry, R., Dookie, T., Foster, E., Hart, C., Omardeen, F., Ramphall, S., Lalla, C., Cheng, J., Elliott, V., Falconer, H., Hurlock-Clarke, L., Ishmael, R., Lalljie, G., Lee, K., Liqui-Lung, A., Massay, R., Mohammed, H., Brown, C., Daniel, R., Didier, M., Salas, Z., CHU Trousseau [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), University of Glasgow, Maria Cecilia Hospital [Cotignola], Royal Brompton Hospital, Montreal Heart Institute Coordinating Centre (MHICC), Université de Montréal (UdeM), Medical University of Silesia (SUM), Université Paris Diderot - Paris 7 (UPD7), Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Dorogoichenko, Aleksandra, Laucevičius, Aleksandras, Jurgaitienė, Rūta, Šlapikas, Rimvydas, Barauskienė, Gražina, Jankauskienė, Edita, Revienė, Sigita, Vaišvila, Tautvydas, Zaronskienė, Danutė, Šlapikienė, Ona Birutė, Kupstytė, Nora, Rinkūnienė, Egidija, Steponėnienė, Rima Vitalija, Kojelienė, Jūratė, Badarienė, Jolita, Dženkevičiūtė, Vilma, Sadauskienė, Eglė, Butkuvienė, Irena, Stankevičius, R., Paliulionienė, R., Snikytė, R., Mažutavičius, R., and CLARIFY Investigators
- Subjects
Male ,Genetics and Molecular Biology (all) ,Heart disease ,medicine.medical_treatment ,atrial fibrillation ,coronary ,anticoagulants ,patients ,atrial flutter ,lcsh:Medicine ,Coronary Artery Disease ,Practice Patterns ,030204 cardiovascular system & hematology ,Chest pain ,Biochemistry ,[SHS]Humanities and Social Sciences ,Cohort Studies ,Coronary artery disease ,Angina ,0302 clinical medicine ,Aged ,Anticoagulants ,Atrial Fibrillation ,Drug Therapy, Combination ,Female ,Guideline Adherence ,Humans ,Outpatients ,Platelet Aggregation Inhibitors ,Practice Patterns, Physicians' ,Registries ,Practice Patterns, Physicians'/statistics & numerical data ,030212 general & internal medicine ,Myocardial infarction ,lcsh:Science ,Stroke ,Anticoagulants/administration & dosage ,Multidisciplinary ,Medicine (all) ,Atrial fibrillation ,Guideline Adherence/statistics & numerical data ,3. Good health ,Combination ,Cardiology ,[SHS] Humanities and Social Sciences ,medicine.symptom ,Research Article ,medicine.medical_specialty ,Coronary Artery Disease/drug therapy ,Agricultural and Biological Sciences (all) ,Biochemistry, Genetics and Molecular Biology (all) ,NO ,03 medical and health sciences ,Drug Therapy ,Internal medicine ,medicine ,Platelet Aggregation Inhibitors/administration & dosage ,Physicians' ,Atrial Fibrillation/drug therapy ,business.industry ,lcsh:R ,Percutaneous coronary intervention ,Outpatients/statistics & numerical data ,medicine.disease ,lcsh:Q ,Human medicine ,business - Abstract
BACKGROUND: Few data are available regarding the use of antithrombotic strategies in coronary artery disease patients with atrial fibrillation (AF) in everyday practice. We sought to describe the prevalence of AF and its antithrombotic management in a contemporary population of patients with stable coronary artery disease.METHODS AND FINDINGS: CLARIFY is an international, prospective, longitudinal registry of outpatients with stable coronary artery disease, defined as prior (≥12 months) myocardial infarction, revascularization procedure, coronary stenosis >50%, or chest pain associated with evidence of myocardial ischemia. Overall, 33,428 patients were screened, of whom 32,954 had data available for analysis at baseline; of these 2,229 (6.7%) had a history of AF. Median (interquartile range) CHA2DS2-VASc score was 4 (3, 5). Oral anticoagulation alone was used in 25.7%, antiplatelet therapy alone in 52.8% (single 41.8%, dual 11.0%), and both in 21.5%. OAC use was independently associated with permanent AF (pCONCLUSIONS: In this contemporary cohort of patients with stable coronary artery disease and AF, most of whom are theoretical candidates for anticoagulation, oral anticoagulants were used in only 47.2%. Half of the patients received antiplatelet therapy alone and one-fifth received both antiplatelets and oral anticoagulants. Efforts are needed to improve adherence to guidelines in these patients.TRIAL REGISTRATION: ISRCTN registry of clinical trials: ISRCTN43070564.
- Published
- 2015
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34. Astronomical calibration and global correlation of the Santonian (Cretaceous) based on the marine carbon isotope record
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Thibault, Nicolas Rudolph, Jarvis, I., Voigt, S., Gale, Andrew Scott, Attree, K., Jenkyns, H. C., Thibault, Nicolas Rudolph, Jarvis, I., Voigt, S., Gale, Andrew Scott, Attree, K., and Jenkyns, H. C.
- Published
- 2016
35. Sepsis rates in hip replacement surgery with special reference to the use of ultra clean air
- Author
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Freeman, M. A. R., Challis, J. H., Zelezonski, J., and Jarvis, I. D.
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- 1977
- Full Text
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36. Black shale deposition, atmospheric CO2 drawdown, and cooling during the Cenomanian-Turonian Oceanic Anoxic Event
- Author
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Jarvis, I., Lignum, J.S., Gröcke, D.R., Jenkyns, H.C., and Pearce, M.A.
- Abstract
Oceanic Anoxic Event 2 (OAE2), spanning the Cenomanian-Turonian boundary (CTB), represents one of the largest perturbations in the global carbon cycle in the last 100 Myr. The δ 13C carb, δ 13C org, and δ 18O chemostratigraphy of a black shale-bearing CTB succession in the Vocontian Basin of France is described and correlated at high resolution to the European CTB reference section at Eastbourne, England, and to successions in Germany, the equatorial and midlatitude proto-North Atlantic, and the U.S. Western Interior Seaway (WIS). 13C (offset between δ 13C carb and δ 13C org) is shown to be a good pCO 2 proxy that is consistent with pCO 2 records obtained using biomarker δ 13C data from Atlantic black shales and leaf stomata data from WIS sections. Boreal chalk δ 18O records show sea surface temperature (SST) changes that closely follow the 13C pCO 2 proxy and confirm TEX 86 results from deep ocean sites. Rising pCO 2 and SST during the Late Cenomanian is attributed to volcanic degassing; pCO 2 and SST maxima occurred at the onset of black shale deposition, followed by falling pCO 2 and cooling due to carbon sequestration by marine organic productivity and preservation, and increased silicate weathering. A marked pCO 2 minimum (∼25% fall) occurred with a SST minimum (Plenus Cold Event) showing >4C of cooling in ∼40 kyr. Renewed increases in pCO 2, SST, and δ 13C during latest Cenomanian black shale deposition suggest that a continuing volcanogenic CO 2 flux overrode further drawdown effects. Maximum pCO 2 and SST followed the end of OAE2, associated with a falling nutrient supply during the Early Turonian eustatic highstand. Copyright 2011 by the American Geophysical Union.
- Published
- 2011
37. The G20 Global Agricultural Monitoring initiative (GEO-GLAM)
- Author
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Soares, J., Williams, M., Jarvis, I., Bingfang, W., Leo, O., Fabre, P., Huynh, F., Kosuth, Pascal, Lepoutre, Damien, Parihar, J.S., Scarascia-Mugnozza, Giuseppe, Justice, C., Williams, D., GEO GENEVA CHE, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Agriculture and Agri-Food [Ottawa] (AAFC), CHINESE ACADEMY OF SCIENCES CHN, European Commission - Joint Research Centre [Ispra] (JRC), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), Institut de Recherche pour le Développement (IRD), Territoires, Environnement, Télédétection et Information Spatiale (UMR TETIS), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-AgroParisTech-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF), GEOSYS RAMONVILLE FRA, ISRO IND, CRA ITA, UNIVERSITY OF MARYLAND USA, USDA FOREST SERVICE USA, National Recherche, irstea, Ministère de l'Agriculture, and Irstea Publications, Migration
- Subjects
[SDE] Environmental Sciences ,ComputingMilieux_GENERAL ,[SDE]Environmental Sciences ,G20 ,GEO-GLAM ,GEO ,FAO - Abstract
The objective of this initiative is to reinforce the international community’s capacity to produce and disseminate relevant, timely and accurate forecasts of agricultural production at national, regional and global scales. This will be achieved by: - enhancing national agricultural reporting systems, including through a global geo-spatial education curriculum to ensure training of participants worldwide; - establishing a sustained international network of agricultural monitoring and research organisations and practitioners; and - creating an operational global agricultural monitoring system of systems based on both satellite and in situ observations.
- Published
- 2011
38. Geochemical and palynological sea-level proxies in hemipelagic sediments: A critical assessment from the Upper Cretaceous of the Czech Republic
- Author
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Sedimentology, Olde, K., Jarvis, I., Uličný, D., Pearce, M.A., Trabucho-Alexandre, J., Čech, S., Gröcke, D.R., Laurin, J., Švábenická, L., Tocher, Bruce, Sedimentology, Olde, K., Jarvis, I., Uličný, D., Pearce, M.A., Trabucho-Alexandre, J., Čech, S., Gröcke, D.R., Laurin, J., Švábenická, L., and Tocher, Bruce
- Published
- 2015
39. Intercontinental correlation of organic carbon and carbonate stable isotope records: evidence of climate and sea-level change during the Turonian (Cretaceous)
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Sedimentology, Jarvis, I., Trabucho-Alexandre, João, Gröcke, D.R., Uličný, D., Laurin, J., Sedimentology, Jarvis, I., Trabucho-Alexandre, João, Gröcke, D.R., Uličný, D., and Laurin, J.
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- 2015
40. Pb and Sr Isotope and Rare Earth Element Composition of Selected Metalliferous Sediments from Sites 597 to 601, Deep Sea Drilling Project Leg 92
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Barrett, T.J., primary, Taylor, P.N., additional, Jarvis, I., additional, and Lugowski, J., additional
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- 1986
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41. Geochemistry and Origin of Eocene-Oligocene Metalliferous Sediments from the Central Equatorial Pacific: Deep Sea Drilling Project Sites 573 and 574
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Jarvis, I., primary
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- 1985
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42. Neogene and Quaternary Dinoflagellate Biostratigraphy of the Eastern Equatorial Pacific: Deep Sea Drilling Project Leg 85
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Jarvis, I., primary and Tocher, B.A., additional
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- 1985
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43. Secular variation in Late Cretaceous carbon isotopes: a new [delta] 13C carbonate reference curve for the Cenomanian - Campanian (99.6 - 70.6 Ma)
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Jarvis, I., Gale, A.S., Jenkyns, H.C., and Pearce, M.A.
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geography - Abstract
Carbon stable-isotope variation through the Cenomanian–Santonian stages is characterized using data for 1769 bulk pelagic carbonate samples collected from seven Chalk successions in England. The sections show consistent stratigraphic trends and δ13C values that provide a basis for highresolution correlation. Positive and negative δ13Cexcursions and inflection points on the isotope profiles are used to define 72 isotope events. Key markers are provided by positive δ13C excursions of up to + 2‰: the Albian/CenomanianBoundary Event; Mid-Cenomanian Event I; theCenomanian/Turonian Boundary Event; the Bridgewick, Hitch Wood and Navigation events of Late Turonian age; and the Santonian/Campanian Boundary Event. Isotope events are isochronous within a framework provided by macrofossil datum levels and bentonite horizons. An age-calibrated composite δ13C reference curve and an isotope event stratigraphy are constructed using data from the English Chalk. The isotope stratigraphy is applied to successions in Germany, France, Spain and Italy. Correlation with pelagic sections at Gubbio, central Italy, demonstrates general agreement between biostratigraphic and chemostratigraphic criteria in the Cenomanian–Turonian stages, confirming established relationships between Tethyan planktonic foraminiferal and Boreal macrofossil biozonations. Correlation of the Coniacian–Santonian stages is less clear cut: magnetostratigraphic evidence for placing the base of Chron 33r near the base of the Upper Santonian is in good agreement with the carbon-isotope correlation, but generates significant anomalies regarding the placement of the Santonian and Campanian stage boundaries with respect to Tethyan planktonic foraminiferal and nannofossil zones. Isotope stratigraphy offers a more reliable criterion for detailed correlation of Cenomanian–Santonian strata than biostratigraphy.With the addition of Campanian δ13C data from one of the English sections, a composite Cenomanian–Campanian age-calibrated reference curve is presented that can be utilized in future chemostratigraphic studies. \ud The Cenomanian–Campanian carbon-isotope curve is remarkably similar in shape to supposedly eustatic sea-level curves: increasing δ13C values accompanying sea-level rise associated with transgression, and falling δ13C values characterizing sea-level fall and regression. The correlation between carbon isotopes and sea-level is explained by variations in epicontinental sea area affecting organic-matter burial fluxes: increasing shallow sea-floor area and increased accommodation space accompanying sea-level rise allowedmore efficient burial ofmarine organic matter, with the preferential removal of 12C from the marine carbon reservoir. During sea-level fall, reduced seafloor area, marine erosion of previously deposited sediments, and exposure of basin margins led to reduced organiccarbon burial fluxes and oxidation of previously deposited organic matter, causing falling δ13C values. Additionally, drowning of carbonate platforms during periods of rapid sea-level rise may have reduced the global inorganic relative to the organic carbon flux, further enhancing δ13C values, while renewed platform growth during late transgressions and highstands prompted increased carbonate deposition. Variations in nutrient supply, changing rates of oceanic turnover, and the sequestration or liberation of methane from gas hydrates may also have played a role in controlling carbon-isotope ratios.
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- 2006
44. Long-term (17 Ma) turbidite record of the timing and frequency of large flank collapses of the Canary Islands
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Hunt, J.E., Talling, P.J., Clare, M.A., Jarvis, I., Wynn, R.B., Hunt, J.E., Talling, P.J., Clare, M.A., Jarvis, I., and Wynn, R.B.
- Abstract
Volcaniclastic turbidites on the Madeira Abyssal Plain provide a record of large-volume volcanic island flank collapses from the Canary Islands. This long-term record spans 17 Ma, and comprises 125 volcaniclastic beds. Determining the timing, provenance and volumes of these turbidites provides key information about the occurrence of mass wasting from the Canary Islands, especially the western islands of Tenerife, La Palma and El Hierro. These turbidite records demonstrate that landslides often coincide with protracted periods of volcanic edifice growth, suggesting that loading of the volcanic edifices may be a key preconditioning factor for landslide triggers. Furthermore, the last large-volume failures from Tenerife coincide with explosive volcanism at the end of eruptive cycles. Many large-volume Canary Island landslides also occurred during periods of warmer and wetter climates associated with sea-level rise and subsequent highstand. However, these turbidites are not serially dependent and any association with climate or sea level change is not statistically significant.
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- 2014
45. Long-term (17 Ma) turbidite record of the timing and frequency of large flank collapses of the Canary Islands
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Hunt, J. E., primary, Talling, P. J., additional, Clare, M. A., additional, Jarvis, I., additional, and Wynn, R. B., additional
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- 2014
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46. Defining Cretaceous Stage Boundaries - time for a new approach?
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Gale, A. S., Kennedy, J., Voigt, Silke, Jarvis, I., Jenkyns, H., Gale, A. S., Kennedy, J., Voigt, Silke, Jarvis, I., and Jenkyns, H.
- Published
- 2009
47. Location and extent of the soils of Southern Ontario: A user's guide to series, catenae and soil legend information
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Jarvis, I. E., MacDonald, K. B., Denholm, K. A., and Greenhouse and Processing Crop Research Centre, Agriculture and Agri-Food Canada
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spatial distribution ,surface soil drainage ,agriculture region ,soil maps ,complex mixtures ,soils - Abstract
This technical bulletin shows the relationship between soils of the agricultural regions of southern Ontario mapped in detail by county and the generalized provincial level characterized by the Soil Landscapes of Canada map (map scale 1:1,000,000). For general users and students of soil science, the report provides an overview of the spatial distribution of soils across southern Ontario. The soil legend provides information about the soil parent material deposits and texture as well as the general category of surface soil drainage. For expert users of soil survey information, this report is intended to provide a framework for broad level soil correlation. It replaces the 1964 publication Soil Associations of Southern Ontario; Report 30.
- Published
- 1998
48. AAFC annual crop inventory
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Fisette, T., primary, Rollin, P., additional, Aly, Z., additional, Campbell, L., additional, Daneshfar, B., additional, Filyer, P., additional, Smith, A., additional, Davidson, A., additional, Shang, J., additional, and Jarvis, I., additional
- Published
- 2013
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49. Geochemical Characterisation and Correlation of Cenomanian Turonian Sediments in Central-eastern Tunisia
- Author
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Mabrouk, A., primary, Khaldi, H., additional, and Jarvis, I., additional
- Published
- 2009
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50. Isotopic Study of a Chalk Petroleum Reservoir – The Late Cretaceous Abiod Formation, Tunisia – Inferred Sea-Level Change and d13C Correlation with the Tethyan, Boreal Realm, and NW Pacific Ocean
- Author
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Mabrouk, A., primary, Jarvis, I., additional, Moody, R.T.J., additional, Belayouni, H., additional, Ben Brahim, A., additional, and De Cabrera, S., additional
- Published
- 2003
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